CN101434131A - Method for producing tablet type metal iodide - Google Patents
Method for producing tablet type metal iodide Download PDFInfo
- Publication number
- CN101434131A CN101434131A CNA2008100984310A CN200810098431A CN101434131A CN 101434131 A CN101434131 A CN 101434131A CN A2008100984310 A CNA2008100984310 A CN A2008100984310A CN 200810098431 A CN200810098431 A CN 200810098431A CN 101434131 A CN101434131 A CN 101434131A
- Authority
- CN
- China
- Prior art keywords
- tablet
- metal iodide
- manufacture method
- powder
- particle diameter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01D—COMPOUNDS OF ALKALI METALS, i.e. LITHIUM, SODIUM, POTASSIUM, RUBIDIUM, CAESIUM, OR FRANCIUM
- C01D3/00—Halides of sodium, potassium or alkali metals in general
- C01D3/12—Iodides
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2004/00—Particle morphology
- C01P2004/60—Particles characterised by their size
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Glanulating (AREA)
- Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to a manufacturing method for a tablet metal iodide, which refers to that metal iodide powder is compressed and molded under a temperature of 10-50 DEG C, and a tablet with a particle size of 5-20mm and a crushing strength of more than 4kgf is manufactured.
Description
Technical field
The present invention relates to a kind of manufacture method of tablet type metal iodide.
Background technology
With KI (Potassium iodide) is that the metal iodide of representative is widely used as polarized film material, nylon (Nylon) stabilizing agent and medical material etc.This metal iodide is usually with Powdered sale, thereby has following problem when long-term storage.
The general hygroscopicity of metal iodide is higher.Therefore, store the metal iodide powder if for example use the higher low density polyethylene (LDPE) (Polyethylene) of poisture-penetrability to make packaging material, then the metal iodide moisture absorption time, can be fixed because of the weight densification of powder self, therefore, pulverous metal iodide can form bulk before the storage behind some months.In addition, when replacing packaging material,, can't reach not fixed fully though can prevent fixedly to a certain extent with the lower material of poisture-penetrability.When metal iodide is fixed, must before using it, breaks fixed part into pieces, thereby reduce operating efficiency with physical methods such as mallets.
Be directed to this, for example having proposed in patent documentation 1～4 described method is the fixed method that prevents of metal halide (Metal halide) of representative with the metal iodide.
The fixed method that prevents of a kind of metal halide-salt (sodium chloride) is disclosed in the patent documentation 1, promptly to after salt spraying sodium hydrogen phosphate (the Disodium hydrogen phosphate) saturated solution, the method for adding magnesium carbonate (Magnesium carbonate) powder again.
Disclose a kind of drying and granulating method of metal iodide in the patent documentation 2, promptly, in fluidized bed spray granulating and drying machine, supplied with the aqueous solution of metal iodide continuously for a kind of metal iodide particle of high workload efficient is provided.
A kind of processing method of metal iodide preparation is disclosed in the patent documentation 3, because of the fixed and aggegation of metal iodide consolidated block takes place in order to prevent promptly, adopt the compression prilling process of briquetting roll-in (Briquettingroll) formula, metal iodide is processed as all granulation bodies that has particle diameter greater than 3mm more than 30%.
Be example with the KI in the crystallinity inorganic compound in the patent documentation 4, disclose the method for handling the granulation product under a kind of high temperature.Promptly for highly purified do not solidify and crystallinity inorganic compound with homogeneous intensity is provided; when adopting roller press type compression comminutor that crystallinity inorganic compound powder is carried out granulation, at the prilling process that disperses to pulverize, sieve high-temperature process granulation product in the operation.
But as mentioned above, metal iodide is widely used as polarized film material, nylon (Nylon) stabilizing agent and medical material etc., when being used to these purposes, requires highly purified metal iodide.Therefore, added additives such as sodium hydrogen phosphate and magnesium carbonate owing to the method for patent documentation 1 and increased impurity, so this method is not suitable for use in the fixed method that prevents of metal iodide.
Though the method for patent documentation 2 has the fixed effect that prevents to a certain degree, implement storage test back and fixed sign just occurred less than one month, therefore the fixed effect that prevents is unsatisfactory.
Though the method for patent documentation 3 also has the fixed effect that prevents to a certain extent, produce fixedly after the long-term storage, the fixed effect that prevents is also undesirable.
In the method for patent documentation 4, down handling the crystallinity inorganic compound at high temperature (60～120 ℃) is necessary condition, and people know with the KI to be that most of metal iodide of representative can be decomposed into free-iodine because of heat or light.Therefore show that high-temperature process can cause the quality of metal iodide to descend, the method for patent documentation 4 is not suitable for use in the fixed method that prevents of metal iodide.
Patent documentation 1: Japanese Patent Application Laid-Open is put down into the 6-24738 communique
Patent documentation 2: Japanese Patent Application Laid-Open is put down into the 9-156920 communique
Patent documentation 3: Japanese Patent Application Laid-Open 2004-217467 communique
Patent documentation 4: Japanese Patent Application Laid-Open is put down into the 6-285355 communique
Summary of the invention
Therefore, in view of this, the object of the present invention is to provide and a kind ofly above-mentioned condition can not take place, even long-term storage also can fully prevent the manufacture method of fixed metal iodide.
The inventor is through studying intensively repeatedly, by under 10～50 ℃ with the moulding of metal iodide powders compression, making crushing strength is the manufacture method of the tablet type metal iodide of 5～20mm greater than 4kgf and particle diameter, has reached above-mentioned purpose.
Even can provide a kind of long-term storage also can fully prevent the manufacture method of fixed metal iodide by the present invention.
In manufacture method of the present invention, because the crushing strength of tablet supposes that greater than 4kgf the tablet projected area of making is 1cm
2, then calculate it and can bear 4kg/cm
2Above pressure.In the past, during the paper bucket (FiberDrum) that will be filled into 35L as the KI powder of metal iodide representative waits, calculated and be about 0.52kg/cm at paper bucket bottom KI powder owing to the suffered maximum pressure of own wt this moment
2Studying these result of calculations finds, when using manufacture method of the present invention, because the pressure that the crushing strength of tablet significantly is subjected to because of own wt greater than tablet, so prevented the very big powder of tablet self broken formation surface area, and prevented the moisture absorption that causes thus and be accompanied by fixed that moisture absorption produces.
In manufacture method of the present invention, by at 10～50 ℃ of compression forming metal iodide powder, prevented the generation of free-iodine, thereby the purity that can prevent metal iodide descends.
In addition, in manufacture method of the present invention, because the particle diameter of tablet, therefore can prevent the undesirable condition that produces during less than 5mm at particle diameter greater than 5mm.Promptly, when particle diameter during less than 5mm, if use tablet machine to carry out moulding, can cause current cost increase just because of the quantity and the inversely proportional increase of particle size of mortar and pestle, can cause productivity hourly to descend because of particle attenuates, so particle diameter can prevent the tendencies such as problem of generation in totle drilling cost (total cost) and operation (handling) greater than 5mm.In addition, in manufacture method of the present invention, because the particle diameter of tablet less than 20mm, therefore can also prevent the substandard product that produces when particle diameter surpasses 20mm.That is, when particle diameter surpassed 20mm, metal iodide is dissolved in needed the long time in the solvent, so particle diameter can prevent the generation of degradation undesirable condition under the operating efficiency less than 20mm.
In manufacture method of the present invention, preferably adopt dry type compression comminutor to carry out above-mentioned compression forming.Can further improve the above-mentioned fixed effect that prevents thus.
In manufacture method of the present invention, the sheet pressure of beating in the above-mentioned compression forming process is preferably 1～20kN.Can further improve the above-mentioned fixed effect that prevents thus.
In manufacture method of the present invention, metal iodide is alkaline metal iodide or alkaline earth metal iodide even more preferably.
Even the invention provides the manufacture method that a kind of long-term storage also can fully prevent fixed metal iodide.Because to adopt the resulting metal iodide of manufacture method of the present invention be tablet, therefore do not have dust from flying in addition, concerning the user the improvement of leap property its operability, thereby can easier operation.
Description of drawings
Fig. 1 is the tablet photo that present embodiment 1 obtains.
Fig. 2 is the schematic diagram of expression tablet particle diameter and dissolution time relation and tablet particle diameter and tablet height relationships.
The specific embodiment
Below the preferred embodiments of the present invention are described in detail, but the present invention is not limited only to this.
Manufacture method of the present invention for example can be used alkaline metal iodides such as lithium iodide, sodium iodide, KI, rubidium iodide, cesium iodide, uses alkaline earth metal iodides such as calcium iodide, strontium iodide, and metal iodide such as silver iodide.Wherein, preferably can use the alkaline metal iodide and the alkaline earth metal iodide that are fit to manufacture method of the present invention, the preferred KI that is more suitable for manufacture method of the present invention that is to use.
The metal iodide powder that uses in manufacture method of the present invention does not comprise basic water and fixedly prevents impurity such as agent, but can sneak into small amount of impurities.In addition,, preferably, can use the powder of crystallizing and drying product,, use particle diameter to be the following powder of 1000 μ m by mobile drying machine drying as the metal iodide powder.
Temperature in the manufacture method of the present invention during compression forming is 10～50 ℃, preferably 10～40 ℃, and normal temperature (15～25 ℃) more preferably.
In manufacture method of the present invention, for example can use dry type compression comminutor to carry out compression forming.Dry type compression comminutor is divided into compressing roller pressure type, briquetting roller press type substantially and beats chip three classes, wherein preferably beats chip (tablet machine).Tablet machine is broadly divided into centrifugal (eccentric) type of single-shot formula and rotation (rotary) type, wherein preferably rotary-type tablet machine.When using rotary-type tablet machine, operation rotor rotation number is 30～60rpm, beats sheet with the sheet pressure of beating of 1～10KN (thousand newton, Kilo Newton).Per hour can produce the tablet of 100～500kg by this rotary-type tablet machine.
Beat sheet pressure, preferably 1～20kN, more preferably 3～15kN when using the dry type beat chip to compress comminutor to carry out above-mentioned compression forming.
The crushing strength of the tablet type metal iodide in the manufacture method of the present invention is 4kgf.In addition, be not particularly limited the upper limit of crushing strength, but for example can be below 30kgf.
The particle diameter of the tablet type metal iodide in the manufacture method of the present invention is 5～20mm, preferably 7～15mm.
Manufacture method of the present invention be characterised in that with the metal iodide powder 10～50 ℃ of compression formings, to be processed as crushing strength be the tablet of 5～20mm greater than 4kgf and particle diameter, and provides a kind of fixed method that prevents of metal iodide.
Embodiment
Below, embodiments of the invention are further described in detail, but the present invention is not limited only to this.In addition, crushing strength is measured log cabin formula numeral (digital) hardometer KHT～20N that uses the former making manufacturing of Co., Ltd. TENG.
First embodiment
KI material powder with (average grain diameter 250 μ m) below the particle diameter 1000 μ m that use the drying machine that flows to make uses rotary-type tablet machine to play the sheet moulding at normal temperatures and makes the tablet of particle diameter as 9mm.The sheet pressure of beating of rotary-type tablet machine is 3～5KN, splits (Capping) and the adhesion of powder on pestle and mortar in order not cause the top, and after having considered shaping speed, the optimum condition of the rotation number of rotor is set at 50rpm.The tablet crushing strength that obtains is about 5～7kgf.The tablet photo that obtains as shown in Figure 1.In addition, " top is split " is meant, the part of tablet adheres on the mortar and pestle of making chip compression comminutor, and this adhesive part is divided into the phenomenon of peeling off of hat-shaped.
Second embodiment
Except beating sheet pressure is 1～1.7KN, and the method for making tablet is identical with first embodiment.The tablet crushing strength that obtains is about 6～10kgf.In addition, do not cause in the tablet manufacturing top split and the adhesion of powder on pestle and mortar.
First Comparative Examples
The particle diameter that the drying machine that use to flow is made is the KI material powder less than 1000 μ m, and the compression comminutor by briquetting roll-in mode carries out granulation.When granulation, the roll-in pressure of compression comminutor is about 5MPa, and rotate roll-in bag (pocket) simultaneously and become coal briquette shape, amygdaloidal different shapes such as (Almond), thus the granulation body of manufacturing different shape.
But the granulation body no matter which kind of situation obtains, all easily cause layering (lamination) thus can not form neat piece agent (briquette) type.In addition, because the granulation body that obtains is discharged from the shape that thin part is connected, the part that it is thin or cut apart fragmentation, or becoming powder sneaks in the granulation body (ratio of inferring like this granulation body that can not fine moulding is 20%～30%).Therefore, can not carry out the tests such as evaluation of aftermentioned storage state.In addition, " layering " be meant that tablet peels off, is divided into the phenomenon of stratiform.
Second Comparative Examples
Prepare the KI powder of particle diameter identical with the KI material powder of use among the embodiment 1, that the mobile drying machine of use is made less than 1000 μ m (average grain diameter 250 μ m).
[evaluation of tablet physical property]
Surface area, particle density, specific area, bulk density (Bulk density) and crushing strength at the tablet of embodiment 1 and 2 are estimated.In addition, surface area, particle density, specific area and the bulk density of powder in the Comparative Examples 2 of object are as a comparison also estimated.The result is as shown in table 1.And, in order to ask the calculation surface area, be real density in the table 1 with the particle density of Comparative Examples 2.In addition, surface area, particle density, specific area and bulk density are asked calculation in such a way.
At first, from the tablet of embodiment 1 and 2 moulding, take out 1, calculate its volume and surface area, simultaneously gravimetry.Specific area is that the value by this surface area calculates divided by gravimetric value, and particle density is calculated divided by bulking value by gravimetric value.
In addition, because the powder of Comparative Examples 2 has the character of size distribution, calculate particle density etc. so can not ask with said method.Therefore, except the powder size of obtaining powder with sieve distributes, also to ask respectively and calculate particle diameter, ask the calculation specific area by these values and above-mentioned real density as positive spherical surface area, volume.
The bulk density of embodiment 1 and 2 tablets is by tablet being put into 250mL graduated cylinder gravimetry, asks divided by volume with this weight and calculates.In addition, the bulk density of Comparative Examples 2 powder is calculated by the same 100mL graduated cylinder of manipulating.
Table 1
| Embodiment 1 | Embodiment 2 | Comparative Examples 2 | |
| Surface area (cm 2) | 3.61 | 3.85 | 134 |
| Particle density (g/cm 3) | 2.76 | 2.62 | (3.13 real density) |
| Specific area (cm 2/g) | 2.30 | 2.36 | 307 |
| Bulk density (g/cm 3) | 2.02 | 1.95 | 1.98 |
| Crushing strength (kgf) | About 5～7 | About 6～10 | - |
Table 1 result shows that with the powder comparison of Comparative Examples 2, the specific area of embodiment 1 and 2 tablets is very little.Therefore, can be easy to imagine that the remote cause that has reduced solidification problem is a hygroscopicity.In addition, the bulk density value of the bulk density of embodiment 1 and 2 tablets and Comparative Examples 2 powder much at one.Therefore showing to use the packaging material identical with the packaging material in the past of packing Comparative Examples 2 powder to pack the tablet of embodiment 1 and 2.
[evaluation that prevents concreteness of tablet]
At the tablet of embodiment 1 and the powder of Comparative Examples 2, adopt following method to carry out the evaluation of storage state.
With the tablet 100kg of plastic bag packaging embodiment 1, the tablet after the packing was stored one month the generation that visual observations is fixed in the 100L of 500 Φ flexible container bag (Flecon) (registration mark).Almost do not change before tablet behind the storage and the packing, do not have fixed fully.And the powder of Comparative Examples 2 is after (Cardboard) pack one month with carton, and powder is fixed along the shape of carton.
[evaluation 1 of tablet dissolved characteristic]
At the tablet of embodiment 1, adopt following method to carry out the evaluation of dissolution characteristics.
Prepare the beaker (Beaker) of two 1L, in each beaker, add the 500ml ion exchange water, use magnetic stirring apparatus (magnetic stirrer) to stir respectively on one side with the speed of 120～150rpm, add on one side above-mentioned sample, at solution temperature dissolution time of assess sample respectively when being 40 ℃ or 25 ℃.Sample size was 25g when solution temperature was 40 ℃, and sample size was 500g when solution temperature was 25 ℃.In addition, dissolution time is meant to sample and dissolves the required time fully, specifically is meant to drop into behind the sample to range estimation to confirm not have time till solid exists.The result who obtains is as shown in table 2.
Table 2
Table 2 is the result show, is respectively at solution temperature under the condition of 40 ℃ and 25 ℃, and the tablet of embodiment 1 demonstrates sufficient dissolution characteristics.
The the 3rd～the 7th embodiment
When the particle diameter of tablet is respectively 5.0,7.0,9.0,11.5, during 15.0mm, beating sheet pressure is 3kN, makes the Thyro-Block of embodiment 3～7 under the identical condition of other condition and embodiment 1.Adopt above-mentioned " evaluation of tablet physical property " method, calculate the surface area make tablet, particle density, specific area, bulk density etc.The result is as shown in table 3.And, when the tablet particle diameter is 9.0mm, will beat that sheet pressure is changed to 3,5,8kN carries out the tablet manufacturing, do not find that the tablet physical property has special obvious variation yet.
Table 3
| Embodiment 3 | Embodiment 4 | Embodiment 5 | Embodiment 6 | Embodiment 7 | |
| The particle diameter of tablet (mm) | 5.0 | 7.0 | 9.0 | 11.5 | 15.0 |
| The height of tablet (mm) | 4.3 | 6.6 | 9.1 | 7.1 | 10.5 |
| Highly/particle diameter | 0.86 | 0.94 | 1.01 | 0.62 | 0.70 |
| Average weight (g/ sheet) | 0.247 | 0.732 | 1.586 | 1.592 | 4.308 |
| The tablet number of every 10g | 40 | 14 | 6 | 6 | 2 |
| Volume (cm 3) | 0.081 | 0.246 | 0.560 | 0.640 | 1.80 |
| Surface area (cm 2) | 1.02 | 2.13 | 3.68 | 3.96 | 8.20 |
| Specific area (cm 2/g) | 4.13 | 2.91 | 2.32 | 2.48 | 1.90 |
| Bulk density (g/cm 3) | 3.03 | 2.97 | 2.83 | 2.49 | 2.39 |
| Crushing strength (kgf) | >20 | >20 | >20 | 8.47 | >20 |
[evaluation 2 of tablet dissolved characteristic]
At the tablet of embodiment 3～7, adopt following method to carry out the evaluation of dissolution characteristics.
In the container of 20～100ml, by adjusting the amount of the tablet number and the aqueous solution, thereby make the value of " tablet weight/water weight " be about 5.4w/v%, adjusting rotor size and revolution simultaneously and make it meet the tablet size, is to measure under 25～27 ℃ the condition to tablet to dissolve required time (dissolution time) fully at solution temperature.Its result is as shown in table 4.
Table 4
| Embodiment 3 | Embodiment 4 | Embodiment 5 | Embodiment 6 | Embodiment 7 | |
| Dissolving number (sheet) | 2 | 1 | 1 | 1 | 1 |
| Water-soluble liquid measure (ml) | 9.0 | 13.5 | 29.0 | 29.3 | 79.0 |
| Tablet weight/water weight (w/v%) | 5.49 | 5.42 | 5.47 | 5.43 | 5.45 |
| Dissolution time (sec) | 130 | 165 | 197 | 145 | 199 |
In addition, the relation of tablet particle diameter and solubility, and the relation of tablet particle diameter and tablet height is respectively as shown in Figure 2.
Claims (4)
1. the manufacture method of a tablet type metal iodide is characterized in that:
10～50 ℃ with the moulding of metal iodide powders compression, making crushing strength is the tablet of 5～20mm greater than 4kgf and particle diameter.
2. manufacture method as claimed in claim 1 is characterized in that: adopt the dry type compression comminutor of beating chip to carry out described compression forming.
3. manufacture method as claimed in claim 2 is characterized in that: the sheet pressure of beating in the described compression forming is 1～20kN.
4. as each described manufacture method in the claim 1 to 3, it is characterized in that: described metal iodide is alkaline metal iodide or alkaline earth metal iodide.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007297100 | 2007-11-15 | ||
| JP2007297100 | 2007-11-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101434131A true CN101434131A (en) | 2009-05-20 |
Family
ID=40708841
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2008100984310A Pending CN101434131A (en) | 2007-11-15 | 2008-05-22 | Method for producing tablet type metal iodide |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JP5070121B2 (en) |
| KR (1) | KR101191718B1 (en) |
| CN (1) | CN101434131A (en) |
| TW (1) | TWI383840B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017019688A (en) * | 2015-07-10 | 2017-01-26 | 株式会社合同資源 | Manufacturing method of metal iodide tablet |
| KR20240039868A (en) * | 2022-09-20 | 2024-03-27 | 한국유나이티드제약 주식회사 | Pharmaceutical composition for thyroid protection and manufacturing method thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06285355A (en) * | 1993-04-02 | 1994-10-11 | Otsuka Chem Co Ltd | Dry granulating method for crystalline inorganic compound |
| JP3562887B2 (en) * | 1995-11-30 | 2004-09-08 | 日宝化学株式会社 | Granules of metal iodide and granulation method thereof |
| JPH1135413A (en) * | 1997-07-15 | 1999-02-09 | Mitsui Chem Inc | Formed solid iodophor |
| JP2004217467A (en) * | 2003-01-15 | 2004-08-05 | Godo Shigen Sangyo Kk | Metallic iodide product and package of metallic iodide product |
| JP2005047764A (en) * | 2003-07-30 | 2005-02-24 | Nippo Kagaku Kk | Manufacturing method of particulate metal iodide |
| JP4976660B2 (en) * | 2005-05-12 | 2012-07-18 | 合同資源産業株式会社 | Method for producing alkali iodide |
-
2008
- 2008-05-05 TW TW097116540A patent/TWI383840B/en active
- 2008-05-08 JP JP2008122565A patent/JP5070121B2/en active Active
- 2008-05-22 CN CNA2008100984310A patent/CN101434131A/en active Pending
- 2008-05-22 KR KR1020080047612A patent/KR101191718B1/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| KR20090050922A (en) | 2009-05-20 |
| JP5070121B2 (en) | 2012-11-07 |
| JP2009137824A (en) | 2009-06-25 |
| TW200920481A (en) | 2009-05-16 |
| KR101191718B1 (en) | 2012-10-16 |
| TWI383840B (en) | 2013-02-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20170119003A1 (en) | Solid milks and method for producing solid milks | |
| RO122626B1 (en) | Process for dry manufacture of pyrotechnical objects | |
| US20210219595A1 (en) | Aerosolizable product | |
| JP2010534698A5 (en) | ||
| CN101434131A (en) | Method for producing tablet type metal iodide | |
| CN107349114A (en) | A kind of new instant dental care microcapsule granule and preparation method thereof | |
| MX2010014503A (en) | Orodispersible mannitol. | |
| EP0047734A1 (en) | Pharmaceutical vehicle composition and process of producing same | |
| US4536389A (en) | Bactericidal tabletting composition and tablets formed therefrom | |
| CN106659184A (en) | Composition in the form of compacted particles and use thereof | |
| CA2083468C (en) | Container systems for agrochemical compositions | |
| JP2023104000A (en) | Tablet making method from medium | |
| EP1015549A1 (en) | Washing and cleaning agent shaped bodies with improved solubility | |
| KR20160117486A (en) | Method and device for external lubribcation of press rolls of a roller compaction plant and an application of the method | |
| JPH07119172B2 (en) | Riboflavin granules without auxiliary agents | |
| CN204865754U (en) | Dry process roll -in granulator | |
| CN102311336B (en) | Method for preparing anhydrous monosodium citrate | |
| US4007052A (en) | Preparation of adjuvant-free fructose tablets | |
| JPS63117905A (en) | Granular tricalcium phosphate composition proper for directly forming compressed tablet | |
| EP0127400A2 (en) | Magnesium oxide containing vehicle for direct compression tableting | |
| JP2004217467A (en) | Metallic iodide product and package of metallic iodide product | |
| US20120114717A1 (en) | Tableting agent having a low water content, and method for the production thereof | |
| CN102802613A (en) | Sodium Ibuprofen Tablets And Methods Of Manufacturing Pharmaceutical Compositions Including Sodium Ibuprofen | |
| JPS6036326A (en) | Direct compression vehicle and manufacture | |
| JP7398775B2 (en) | Foaming molded bath agent |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20090520 |