CN101433527A - Use of plant capsule in powder spray - Google Patents
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- CN101433527A CN101433527A CNA2007101501483A CN200710150148A CN101433527A CN 101433527 A CN101433527 A CN 101433527A CN A2007101501483 A CNA2007101501483 A CN A2007101501483A CN 200710150148 A CN200710150148 A CN 200710150148A CN 101433527 A CN101433527 A CN 101433527A
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Abstract
The invention relates to application of a vegetable capsule in a powder spray, and provides a novel capsule type aerosol inhalant administration device. In the invention, the vegetable capsule is selected to replace the prior hollow capsule; the vegetable capsule has good effect on administration application of the capsule type aerosol inhalant administration device, and can not generate capsule particles or powder, so that in the process of administration suction, the problem caused by the capsule particles and powder can be well solved. Meanwhile, the emptying rate of the vegetable capsule is basically equivalent to that of an animal capsule used in the aerosol inhalant under the condition of normal temperature, while the emptying rate of the vegetable capsule is superior to that of the animal capsule under other conditions with better administration effect.
Description
Technical field
The present invention relates to the application of plant capsule, especially relate to the application of plant capsule in powder spray.
Background technology
Document Chem Pharm Bel, 1997, to mention among the 45:911, the carrier of powder spray particle diameter 50 μ m-100 μ m commonly used mixes with particle diameter 0.5～7 μ m drug powder, makes drug powder be adsorbed in carrier surface.By inspiratory airflow, make powder spray obtain enough functions and enter upper respiratory tract during suction.Respiratory tract narrows down in people's process along with inhaling, and air velocity is accelerated, and separates with medicine.Separate the back drug powder to continue under the high gas flow effect, to enter therapentic part or human lung and play therapeutical effect.
2005 14 volumes of document " Chinese Pharmaceutical " the 1st phase 23-24 page or leaf, the capsule type inhalation aerosol powder doser is a first generation product, this device is comparatively simple, use principle is, capsule is broken by metal blade or acupuncture during use, capsule can rotate vibration in suction process, thereby pharmaceutical powder discharges from the hole of capsule wall, and medicine is with the air-breathing respiratory tract that enters.Sucking powder spray doser second filial generation product is the vesicle type, has the dish formula to receive device and discoid inhaler.Contain a plurality of medicine carrying vesicles at inhaler, during use, puncture vesicle after, suck medicine by suction nozzle, runner can turn to next vesicle automatically, it is comparatively convenient to use.Sucking powder spray doser third generation product is the multiple dose reservoir devices, and this also has a lot of products, and the capacity that these suction apparatus are packed into than the second filial generation is bigger, use more convenient, some has the motor machine function, also has dose counter etc., and dosage sucks more accurate more convenient.
Suck the first generation product capsule type inhalation aerosol powder of powder spray doser, because the capsule fill is convenient, the suction apparatus simple cheap, use cost is relatively low, and capsule filling machine and suction apparatus are distinct simultaneously.Secondary product vesicle type and multiple dose reservoir devices behind the suction powder spray doser, the equipment requirements of fill drug powder and suction apparatus is high especially, and industrial cost is higher, and use cost is also higher relatively.So domestic capsule type inhalation aerosol powder doser that all is to use basically at present.
Traditional capsule type inhalation aerosol powder doser has a shortcoming; the capsule that uses all is the animal Capsules; also be gelatine capsule; the animal Capsules mainly is from animal such as cattle; extract in the osteoderm of pig; main material is a gelatin; this Capsules is harder; it is more crisp that (document " Chinese Pharmaceutical " was rolled up 82 pages of the 8th phases in 2003 12; Zhou Jianping; a new generation capsule---the characteristic and the application thereof of plant capsule), for this reason, in sucking the use of powder spray doser; usually can be because of after puncturing; produce capsule particle and broken end, these capsule particles and broken end scratch respiratory tract easily along with the administration suction process enters respiratory tract; influence the flowability of medicine simultaneously, Emptying Rate and administering effect are had certain influence.。
Document " characteristic of capsule of new generation---plant capsule and application thereof " is also mentioned, plant capsule is to be capsule material (hydroxypropyl methylcellulose) with the plant cellulose, the base stock that contains polysaccharide and plant cell wall dips in mold technique and drying technology is refining forms through special.Infiltration along with the pure natural notion, plant capsule is not only welcome at American-European medicine and functional food market, also become the new choosing of capsule formulation in developing countries such as Asia, this capsule new product can be positioned All Pure Nature or biological product, has complied with the consumption of current uphold nature.And the relative animal capsule of plant capsule cost cost wants high, is mainly at present on health food (dietary supplement) market that it is generally acknowledged, vegetable material is tasted more safer than animal capsule.
Do not find both at home and abroad that at present plant capsule is used for capsule type inhalation aerosol powder.Some characteristic of it is generally acknowledged plant capsule itself is unsuitable for capsule type inhalation aerosol powder.Tracing it to its cause may be that plant capsule mainly is the composition of fiber and polysaccharide, the capsule wall density of making is less, structure is fibrous, use microscopic examination comparison plant capsule and gelatine capsule inside and outside wall to find, the inside and outside wall of plant capsule wants big compared with the capsular inside and outside wall roughness of animal, and the major ingredient of powder spray is generally all very thin, generally, the too big this situation of roughness influences the Emptying Rate of medicine easily, because from physical angle, roughness is big, and the friction force of major ingredient and capsule-wall is relatively large.Document " characteristic of capsule of new generation---plant capsule and application thereof " is mentioned simultaneously: the logical oxygen of plant capsule is obviously greater than gelatine capsule (166/4.3=38.6 doubly), point out its seal poor, it is generally acknowledged that seal causes capsule 's content to harden than missionary society, thereby influence Emptying Rate.The Emptying Rate of powder spray suction apparatus is an important indicator, and Chinese Pharmacopoeia 2005 editions is gone up regulation powder spray Emptying Rate must not be lower than 90%.
Summary of the invention
Shortcoming at traditional capsule type inhalation aerosol powder doser, the invention provides a kind of new capsule type inhalation aerosol powder doser, we select for use plant capsule to replace conventional Capsules, it is very good to be surprised to find plant capsule effect in the administration of capsule type inhalation aerosol powder doser is used, can not produce capsule particle and broken end, in the administration suction process, well solved like this because the problem that bring at capsule particle and broken end.Use plant capsule and the capsular Emptying Rate of animal in sucking powder spray have been compared in our research simultaneously, find unexpectedly, use plant capsule suitable substantially under normal temperature condition with the capsular Emptying Rate of animal, and Emptying Rate wants high relatively under some other condition, administering effect is better.Trace it to its cause, though the inwall of plant capsule is comparatively coarse, can make some contents remain in inside capsule wall, but may be that the shared ratio of adjuvant is quite big in the capsule type inhalation aerosol powder, general above 95%, cause residual in plant capsule and animal capsule of medicine in fact to differ few, and plant capsule can not produce capsule particle and broken end, the aperture is even, capsule 's content more easily enters respiratory tract, thus caused above-mentioned result, and remain in inside capsule wall just because of content thinner in the plant capsule (the carrier particle diameter is 50 μ m-100 μ m), thereby increased the seal of plant capsule, significantly reduced content and hardened.
The invention provides the application of plant capsule, it is characterized in that the application of plant capsule at the capsule type inhalation aerosol powder doser.This process is, drug powder is packed in the plant capsule, then the plant capsule that medicine is housed placed in the capsule type inhalation aerosol powder doser, capsule is punctured, air-breathing with nose or mouth, pharmaceutical powder discharges from the hole of capsule wall then, and medicine is with the air-breathing respiratory tract that enters.
Plant capsule provided by the invention is in the application of capsule type inhalation aerosol powder doser.The said plant capsule of the present invention is the Capsules made from the plant cellulose raw material, plant capsule is to be capsule material (hydroxypropyl methylcellulose) with the plant cellulose, the base stock that contains polysaccharide and plant cell wall, mold technique and drying technology are refining to form through dipping in.The said drug powder of the present invention is meant the inhaled medication thing powder that is used for the treatment of asthma, comprise glucocorticoid, the beta 2 receptor agonist, theophylline, medicines such as anticholinergic agents are selected from wherein a kind of or wherein several, preferred glucocorticoid, a kind of in the beta 2 receptor agonist or wherein several, more preferably R type-budesonide, ciclesonide, beclometasone, fluticasone propionate, momestasone furoate, formoterol, salmaterol a kind of or wherein several; Most preferably R type-budesonide, ciclesonide, fluticasone propionate, formoterol, salmaterol a kind of or wherein several.Formoterol is generally selected the form of hydrochlorate for use, as formoterol fumarate and formoterol tartrate; Salmaterol is generally selected the form of hydrochlorate for use, as former times naphthoic acid salmaterol, carbonaphthoic acid salmaterol etc.
The plant capsule preferred plant Capsules that the present invention relates to, promptly be used for the capsule shells that the fill medicine is used, can be selected from the Vcaps plant capsule of Suzhou Capsule Co., Ltd, the plant capsule of Zhejiang remittance power capsule company limited, the Sargassum polysaccharides Capsules of Qinhuangdao capsule for medicine company, the plant hollow capsule of Anhui Huangshan Capsule Co., Ltd..Plant hollow capsule with some other functions such as with health role, also can be used for the present invention.The plant capsule mentioned of the present invention wherein, its plant capsule material is based on polymer composition, and this polymer composition comprises:
A) water content 2-10% and viscosity are being determined as at least a cellulose ether 90-99.98 weight % of 3-15cPs in 2% aqueous solution under 20 ℃,
B) Gellan gum 0.01-5 weight % and
C) be selected from the chelating agen 0.01-8 weight % of ethylene diaminetetraacetic acid, sodium citrate, citric acid and composition thereof.
Plant capsule powder spray doser provided by the invention and animal capsule powder spray doser are in use with the obvious advantage, after puncturing capsule during use, capsule is not broken, there are not capsule particle and broken end, we have done a large amount of contrast tests, and wherein plant capsule is selected the Vcaps plant capsule (numbering 1) of Suzhou Capsule Co., Ltd, the Sargassum polysaccharides Capsules (numbering 2) of Qinhuangdao capsule for medicine company for use; The gelatin Capsules (numbering 4) that the animal capsule selects for use Xinchang county the 6th soft gelatin capsule factory (numbering 3) and Zhejiang remittance power capsule company limited to produce, capsule model: 3
#Number capsule; The powder spray doser is selected the product of Shanghai balance pharmaceutical factory for use.
Test method: prepare same Mission Number 1,2,3, each 90 of 4 capsules are respectively charged into the dry powder for preparing in plant capsule and the animal capsule, under different conditions, placed 1 month down at room temperature (25 ℃ ± 2 ℃/60%RH ± 10%) respectively, 3 months, respectively at high temperature (60 ℃ ± 2 ℃), high humidity (25 ℃ ± 2 ℃/90%RH ± 5%) and low humidity (25 ℃ ± 2 ℃/20%RH ± 5%) were placed 5 days down, 10 days, get numbering 1,2,3 respectively at every turn, each 10 of 4 capsules, carry out the powder spray inhalation test respectively, observe puncturing phenomenon, percentage of damage after statistics punctures and the average Emptying Rate of calculating.Wherein different conditions, with reference to Chinese Pharmacopoeia 2005 crude drug and pharmaceutical preparation stability test guideline, RH represents relative humidity, the numerical range that several representatives of ± back can be floated, percentage of damage is meant that in test after capsule was punctured, cracked probability had taken place capsule, and the process along with sucking has part capsule particle to be sucked out the powder spray doser.The calculating of Emptying Rate is according to the Emptying Rate method of 2005 editions appended powder sprays of appendix IL of Chinese Pharmacopoeia.The pharmaceutical powder that this experiment is selected for use is the powder spray pharmaceutical powder according to Chinese Pharmacopoeia standard in 2005, the drug particle size size is below 10 μ m, wherein major part should be below 5 μ m, and for improving powder flowbility, having added the carrier particle diameter is the crystallization lactose of 50 μ m-100 μ m; The powder that this experiment is selected for use is a powder among the embodiment two.
Table 1 plant capsule powder spray doser and the contrast of animal capsule powder spray doser data:
From the data show of table 1, plant capsule powder spray doser provided by the invention and animal capsule powder spray doser are in use with the obvious advantage, have solved capsule particle and broken last problem that the softgel shell fragmentation brings effectively.Under different conditions, puncture capsule during use after, plant capsule powder spray doser does not produce capsule particle and broken end; And animal capsule powder spray doser is except under super-humid conditions, because the cause that the softgel shell deliquescing becomes sticky, fragmentation does not take place in the process that punctures, under remaining condition, the process that punctures has all produced capsule particle and broken end to some extent, 3 months animal capsules of room temperature percentage of damage has reached 40%, and high temperature is after 10 days, and percentage of damage is up to 90%.
This experimental data shows that also plant capsule is under the condition of room temperature, high temperature and low humidity, and stability is all better; Under the condition of high humidity, deliquescing slightly.And the animal capsule is under the condition of room temperature, high temperature and low humidity, and it is all poor that stability is compared plant capsule, and particularly under the condition of high humidity, softgel shell becomes sticky.Wherein in suction process, under 0 day condition of room temperature, plant capsule is suitable substantially with the capsular Emptying Rate of animal, illustrate that the adaptability of plant capsule in powder spray is better,, on the result, can see along with room temperature 1 month and 3 months, under the plant capsule fill condition, stability is higher, and Emptying Rate is more or less the same, and is suitable substantially with 3 months Emptying Rate of room temperature as room temperature 0 day; And under the animal capsule fill condition, less stable, the time is bigger to the Emptying Rate influence, differs about 3% as room temperature 0 day and 3 months Emptying Rate of room temperature.And under some other condition, the Emptying Rate of plant capsule is than animal capsule Emptying Rate height, possible reason is under various conditions, drug powder in the plant capsule than the stability in the animal capsule better, so the mobile state when drug powder keeps 0 day always.
Replace the application of animal capsule in the powder spray suction apparatus by plant capsule, from experimental data as can be seen, the present invention also has advantage: plant capsule replaces the application of animal capsule in the powder spray suction apparatus, is easy to preserve, shelf-life is longer, characteristics such as better effects if.
In addition, we change the experiment that different powder is investigated above percentage of damage and Emptying Rate at normal temperatures, selected R-budesonide (table 2) medicated powder of prescription among the embodiment three for use, fluticasone propionate (table 3) medicated powder of prescription among the embodiment five, momestasone furoate (table 4) medicated powder of prescription among the embodiment 11, the fluticasone propionate and the former times naphthoic acid salmaterol medicated powder (table 5) of prescription among the embodiment six, prepare same Mission Number 1,2,3, each 120 of 4 capsules (each 30 of every kind of capsules of every kind of medicine), the dry powder for preparing is respectively charged in plant capsule and the animal capsule, get numbering 1,2,3 respectively at every turn, each 10 of 4 capsules, carry out the powder spray inhalation test respectively, observe puncturing phenomenon, percentage of damage after statistics punctures and the average Emptying Rate of calculating.Normal temperature condition wherein, with reference to Chinese Pharmacopoeia 2005 crude drug and pharmaceutical preparation stability test guideline, percentage of damage is meant in test, after capsule is punctured, cracked probability has taken place in capsule, and along with the process that sucks, has part capsule particle to be sucked out the powder spray doser.The calculating of Emptying Rate is according to the Emptying Rate method of 2005 editions appended powder sprays of appendix IL of Chinese Pharmacopoeia.
The pharmaceutical powder that this experiment is selected for use is the powder spray pharmaceutical powder according to Chinese Pharmacopoeia standard in 2005, the drug particle size size is below 10 μ m, wherein major part should be below 5 μ m, for improving powder flowbility, having added the carrier particle diameter is the crystallization lactose of 50 μ m-100 μ m, and the experimental result that obtains is as follows:
The plant capsule powder spray doser of table 2 R-budesonide and the contrast of animal capsule powder spray doser data:
The plant capsule powder spray doser of table 3 fluticasone propionate and the contrast of animal capsule powder spray doser data:
The plant capsule powder spray doser of table 4. momestasone furoate and the contrast of animal capsule powder spray doser data:
The plant capsule powder spray doser of table 5 composite powder and the contrast of animal capsule powder spray doser data:
Data cases from table 2 to table 5 shows that the conclusion that draws and the conclusion of table 1 are consistent.That is, the effect of plant capsule in the powder spray device is obviously good than animal capsule, can capsule particle and broken end; And illustrated that different drug powders is all better than the stability in the animal capsule in plant capsule, thus use plant capsule to replace the application of animal capsule in powder spray, with the obvious advantage.
Plant capsule mainly is the composition of fiber and polysaccharide, the capsule wall density of making is less, structure is fibrous, use microscopic examination comparison plant capsule and gelatine capsule inside and outside wall to find, the inside and outside wall of plant capsule wants big compared with the capsular inside and outside wall roughness of animal, and the major ingredient of powder spray is generally all very thin, generally, the too big this situation of roughness influences the Emptying Rate of medicine easily, because from physical angle, roughness is big, and the friction force of major ingredient and capsule-wall is relatively large.But actual experiment confirm, in sucking powder spray, use plant capsule and the capsular Emptying Rate of animal, find unexpectedly, use plant capsule suitable substantially under 0 day condition of room temperature with animal capsule Emptying Rate, and Emptying Rate wants high relatively under some other condition, stability will be got well, and administering effect is better.For this reason our experiment of further having done angle of repose confirm drug powder in plant capsule than the good stability in the animal capsule.
Angle of repose test method: the condition of mentioning with above experiment, prepare same Mission Number 1,2,3,4 capsule, the major ingredient dry powder of prescription among the embodiment two for preparing is respectively charged in plant capsule and the animal capsule, placed 3 months 1 month down at room temperature (25 ℃ ± 2 ℃/60%RH ± 10%).Adopt the fixed funnel method, be about to funnel and be fixed on suitable height H, powder is put in the funnel, make under the spontaneous current in heapsly, till the top of cone rigidly connects when contacting hopper outlet, measure the radius r of circular cone bottom surface, calculate angle of repose, angle of repose=arctg (H/r), experimental result such as table 6:
Determination data contrast angle of repose of table 6. plant capsule powder spray and animal capsule powder spray:
As everyone knows, the powder spray powder is bigger angle of repose, and is mobile just poor, causes Emptying Rate to reduce.From table 6 data as can be seen, from 0 day to 3 months, the angle of repose of plant capsule powder spray was constant substantially under the room temperature, so Emptying Rate is also constant substantially, and changed the angle of repose of animal capsule powder spray greatly, so that Emptying Rate also changes is bigger.Simultaneously illustrate that also the plant capsule powder spray is better than the stability of animal capsule powder spray.
Plant capsule powder spray doser provided by the invention and animal capsule powder spray doser are in use with the obvious advantage.Be mainly reflected in:
(1) plant capsule can not produce capsule particle and powder when the powder spray doser uses.
(2) drug powder will be got well compared with the stability in the animal capsule at plant capsule, thereby has kept good mobility, has kept Emptying Rate preferably, has kept administering effect preferably.
The specific embodiment
Below will the invention will be further described by embodiment, these descriptions are not that content of the present invention is done further to limit.One skilled in the art will understand that to be equal to replacement to what technical characterictic of the present invention was done, or corresponding the improvement, still belong within protection scope of the present invention.
Plant capsule is selected the Vcaps plant capsule (numbering 1) of Suzhou Capsule Co., Ltd, the Sargassum polysaccharides Capsules (numbering 2) of Qinhuangdao capsule for medicine company for use, and the powder spray doser is selected the product of Shanghai balance pharmaceutical factory for use.
Embodiment one
Taking by weighing appropriate amount of drug and adjuvant powder thereof packs in the hollow Vcaps plant capsule, install capsule, accurately weighing capsule grain places the plant capsule that medicine is housed in the powder spray doser then, extruding, capsule is punctured, and aspirates each 1.5 seconds 4 times with the air velocity of per minute 60L ± 5L, claim to decide weight, wipe away residually only with little brush or suitable apparatus, claim again to decide softgel shell weight, obtain this Emptying Rate.
Embodiment two
Contain ciclesonide 160 μ g according to every capsules, the drug powder of the prescription of crystallinity lactose 16mg, pack in the hollow Vcaps plant capsule, install capsule, then the plant capsule that medicine is housed is placed in the powder spray doser, extruding, capsule is punctured, with nose or mouthfuls air-breathing three times, medicine is with the air-breathing respiratory tract that enters.
Embodiment three
The method that contains ZL2005100152715 according to every capsules makes R type budesonide 200 μ g, the drug powder of the prescription of crystallinity lactose 20mg, pack in the hollow seaweed polysaccharide plant capsule, install capsule, then the plant capsule that medicine is housed is placed in the powder spray doser, extruding, capsule is punctured, with nose or mouthfuls air-breathing three times, medicine is with the air-breathing respiratory tract that enters.
Embodiment four
The method that contains ZL2005100152715 according to every capsules makes budesonide 200 μ g, the drug powder of the prescription of glycine 20mg, pack in the hollow seaweed polysaccharide plant capsule, install capsule, then the plant capsule that medicine is housed is placed in the powder spray doser, extruding, capsule is punctured, with nose or mouthfuls air-breathing three times, medicine is with the air-breathing respiratory tract that enters.
Embodiment five
Every capsules is contained fluticasone propionate 125 μ g, the drug powder of the prescription of chitosan 15mg, pack in the hollow seaweed polysaccharide plant capsule, install capsule, then the plant capsule that medicine is housed is placed in the powder spray doser, extruding, capsule is punctured, with nose or mouthfuls air-breathing three times, medicine is with the air-breathing respiratory tract that enters.
Embodiment six
Every capsules is contained fluticasone propionate 100 μ g, former times naphthoic acid salmaterol 5 μ g, the drug powder of the prescription of chitosan 20mg, pack in the hollow Vcaps plant capsule, install capsule, then the plant capsule that medicine is housed is placed in the powder spray doser, extruding, capsule is punctured, and with nose or mouthfuls air-breathing three times, medicine is with the air-breathing respiratory tract that enters.
Embodiment seven
Every capsules is contained ciclesonide 80 μ g, formoterol fumarate 4 μ g, the drug powder of the prescription of crystallinity lactose 20mg, pack in the hollow seaweed plants capsule, install capsule, then the plant capsule that medicine is housed is placed in the powder spray doser, extruding, capsule is punctured, and with nose or mouthfuls air-breathing three times, medicine is with the air-breathing respiratory tract that enters.
Embodiment eight
Every capsules is contained budesonide 100 μ g, formoterol fumarate 4 μ g, the drug powder of the prescription of crystallinity lactose 20mg, pack in the hollow Vcaps plant capsule, install capsule, then the plant capsule that medicine is housed is placed in the powder spray doser, extruding, capsule is punctured, and with nose or mouthfuls air-breathing three times, medicine is with the air-breathing respiratory tract that enters.
Embodiment nine
Every capsules is contained ciclesonide 100 μ g, former times naphthoic acid salmaterol 5 μ g, the drug powder of the prescription of crystallinity lactose 20mg, pack in the hollow Vcaps plant capsule, install capsule, then the plant capsule that medicine is housed is placed in the powder spray doser, extruding, capsule is punctured, and with nose or mouthfuls air-breathing three times, medicine is with the air-breathing respiratory tract that enters.
Embodiment ten
Every capsules is contained momestasone furoate 100 μ g, former times naphthoic acid salmaterol 5 μ g, the drug powder of the prescription of crystallinity lactose 20mg, pack in the hollow Vcaps plant capsule, install capsule, then the plant capsule that medicine is housed is placed in the powder spray doser, extruding, capsule is punctured, and with nose or mouthfuls air-breathing three times, medicine is with the air-breathing respiratory tract that enters.
Embodiment 11
Every capsules is contained momestasone furoate 100 μ g, the drug powder of the prescription of crystallinity lactose 20mg, pack in the hollow seaweed plants capsule, install capsule, then the plant capsule that medicine is housed is placed in the powder spray doser, extruding, capsule is punctured, with nose or mouthfuls air-breathing three times, medicine is with the air-breathing respiratory tract that enters.
Claims (9)
1. the application of plant capsule in the capsule type inhalation aerosol powder doser.
2. the application of plant capsule as claimed in claim 1, it is characterized in that plant capsule in the application process of capsule type inhalation aerosol powder doser is: drug powder is packed in the plant capsule, then the plant capsule that medicine is housed is placed in the capsule type inhalation aerosol powder doser, capsule is punctured, air-breathing with nose or mouth, pharmaceutical powder discharges from the hole of capsule wall then, and medicine is with the air-breathing respiratory tract that enters.
3. the application of plant capsule as claimed in claim 1 or 2 is characterized in that plant capsule is the Capsules made from the plant cellulose raw material.
4. the application of plant capsule as claimed in claim 1 or 2 is characterized in that plant capsule is is the capsule material with the plant cellulose, contains the base stock of polysaccharide and plant cell wall, and mold technique and drying technology are refining to form through dipping in.
5. the application of plant capsule as claimed in claim 1 or 2 is characterized in that the plant capsule material is based on polymer composition, and this polymer composition comprises:
A) water content 2-10% and viscosity are being determined as at least a cellulose ether 90-99.98 weight % of 3-15cPs in 2% aqueous solution under 20 ℃,
B) Gellan gum 0.01-5 weight % and
C) be selected from the intercalating agent 0.01-8 weight % of ethylene diaminetetraacetic acid, sodium citrate, citric acid and composition thereof.
6. the application of plant capsule as claimed in claim 1 or 2 is characterized in that drug powder is the inhaled medication thing powder that is used for the treatment of asthma, is selected from glucocorticoid, beta 2 receptor agonist, theophylline, a kind of or wherein several of anticholinergic agents.
7. the application of plant capsule as claimed in claim 1 or 2 is characterized in that drug powder is the inhaled medication thing powder that is used for the treatment of asthma, is selected from glucocorticoid, beta 2 receptor agonist a kind of or wherein several.
8. the application of plant capsule as claimed in claim 1 or 2, it is characterized in that drug powder is the inhaled medication thing powder that is used for the treatment of asthma, be selected from a kind of of R type-budesonide, ciclesonide, beclometasone, fluticasone propionate, furancarboxylic acid Mo Meisong, formoterol, salmaterol or wherein several.
9. the application of plant capsule as claimed in claim 1 or 2, it is characterized in that drug powder is the inhaled medication thing powder that is used for the treatment of asthma, be selected from a kind of of R type-budesonide, ciclesonide, fluticasone propionate, formoterol, salmaterol or wherein several.
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| CNA2007101501483A CN101433527A (en) | 2007-11-13 | 2007-11-13 | Use of plant capsule in powder spray |
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| CNA2007101501483A CN101433527A (en) | 2007-11-13 | 2007-11-13 | Use of plant capsule in powder spray |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102247597A (en) * | 2010-05-19 | 2011-11-23 | 天津金耀集团有限公司 | Novel inhalant containing glucocorticoid and bronchodilator |
| WO2012041031A1 (en) * | 2010-09-28 | 2012-04-05 | 健乔信元医药生技股份有限公司 | Compound composition for inhalation used for treating asthma |
| CN108451920A (en) * | 2018-03-14 | 2018-08-28 | 绍兴康可胶囊有限公司 | A kind of suction mist formula capsule and preparation method thereof |
| CN110133194A (en) * | 2019-05-27 | 2019-08-16 | 江苏力凡胶囊有限公司 | A method of measurement Foradil Aerolizer formoterol fumarate Capsules Emptying Rate |
-
2007
- 2007-11-13 CN CNA2007101501483A patent/CN101433527A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102247597A (en) * | 2010-05-19 | 2011-11-23 | 天津金耀集团有限公司 | Novel inhalant containing glucocorticoid and bronchodilator |
| CN102247597B (en) * | 2010-05-19 | 2015-01-07 | 天津金耀集团有限公司 | Novel inhalant containing glucocorticoid and bronchodilator |
| WO2012041031A1 (en) * | 2010-09-28 | 2012-04-05 | 健乔信元医药生技股份有限公司 | Compound composition for inhalation used for treating asthma |
| US8877740B2 (en) | 2010-09-28 | 2014-11-04 | Intech Biopharm Ltd. | Compound composition for inhalation used for treating asthma |
| AU2011307899B2 (en) * | 2010-09-28 | 2015-03-12 | Intech Biopharm Ltd. | Compound composition for inhalation used for treating asthma |
| CN108451920A (en) * | 2018-03-14 | 2018-08-28 | 绍兴康可胶囊有限公司 | A kind of suction mist formula capsule and preparation method thereof |
| CN110133194A (en) * | 2019-05-27 | 2019-08-16 | 江苏力凡胶囊有限公司 | A method of measurement Foradil Aerolizer formoterol fumarate Capsules Emptying Rate |
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