CN101431996A - 蛋白质异戊二烯基转移酶的抑制剂 - Google Patents
蛋白质异戊二烯基转移酶的抑制剂 Download PDFInfo
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- CN101431996A CN101431996A CNA2007800144909A CN200780014490A CN101431996A CN 101431996 A CN101431996 A CN 101431996A CN A2007800144909 A CNA2007800144909 A CN A2007800144909A CN 200780014490 A CN200780014490 A CN 200780014490A CN 101431996 A CN101431996 A CN 101431996A
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/48—Sulfur atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
Landscapes
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- Health & Medical Sciences (AREA)
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- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
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| CN112574041A (zh) * | 2020-12-25 | 2021-03-30 | 温州大学新材料与产业技术研究院 | 一种手性β羟基1,3-二羰基类化合物的合成方法 |
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| US6777217B1 (en) | 1996-03-26 | 2004-08-17 | President And Fellows Of Harvard College | Histone deacetylases, and uses related thereto |
| US20030129724A1 (en) | 2000-03-03 | 2003-07-10 | Grozinger Christina M. | Class II human histone deacetylases, and uses related thereto |
| CA2937005A1 (en) | 2005-03-22 | 2006-09-28 | President And Fellows Of Harvard College | Treatment of protein degradation disorders |
| AU2007345292B2 (en) | 2006-02-14 | 2013-10-31 | Dana-Farber Cancer Institute, Inc. | Bifunctional histone deacetylase inhibitors |
| CN101431996A (zh) | 2006-03-22 | 2009-05-13 | 加利福尼亚大学董事会 | 蛋白质异戊二烯基转移酶的抑制剂 |
| US8304451B2 (en) * | 2006-05-03 | 2012-11-06 | President And Fellows Of Harvard College | Histone deacetylase and tubulin deacetylase inhibitors |
| CA2731730C (en) | 2008-07-23 | 2017-06-13 | President And Fellows Of Harvard College | Deacetylase inhibitors and uses thereof |
| US9125821B2 (en) | 2008-07-28 | 2015-09-08 | The Regents Of The University Of California | Nanodrug targeting protein geranylgeranylation |
| US20110178138A1 (en) | 2008-07-28 | 2011-07-21 | The Regents Of The University Of California | Inhibitors of protein prenyltransferases |
| WO2011019393A2 (en) | 2009-08-11 | 2011-02-17 | President And Fellows Of Harvard College | Class- and isoform-specific hdac inhibitors and uses thereof |
| WO2012097371A2 (en) * | 2011-01-14 | 2012-07-19 | The Regents Of The University Of California | Chemical inhibitors of cholesterol biosynthesis and venous angiogenesis |
| WO2012116181A2 (en) * | 2011-02-24 | 2012-08-30 | The Regents Of The University Of California | Small molecules for endothelial cell activation |
| DK2707031T3 (da) * | 2011-05-08 | 2019-10-07 | Legochem Biosciences Inc | Protein-active agent conjugates and method for preparing the same |
| US20150087628A1 (en) * | 2012-04-10 | 2015-03-26 | The Regents Of The University Of California | Compositions and methods for treating cancer |
| WO2019076269A1 (zh) | 2017-10-16 | 2019-04-25 | 清华大学 | 甲羟戊酸通路抑制剂及其药物组合物 |
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| US4559157A (en) * | 1983-04-21 | 1985-12-17 | Creative Products Resource Associates, Ltd. | Cosmetic applicator useful for skin moisturizing |
| LU84979A1 (fr) * | 1983-08-30 | 1985-04-24 | Oreal | Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux |
| US4820508A (en) * | 1987-06-23 | 1989-04-11 | Neutrogena Corporation | Skin protective composition |
| US4992478A (en) * | 1988-04-04 | 1991-02-12 | Warner-Lambert Company | Antiinflammatory skin moisturizing composition and method of preparing same |
| US4938949A (en) * | 1988-09-12 | 1990-07-03 | University Of New York | Treatment of damaged bone marrow and dosage units therefor |
| AU2003259717A1 (en) | 2002-08-07 | 2004-02-25 | Bristol-Myers Squibb Company | Modulators of rabggt and methods of use thereof |
| CA2528652A1 (en) * | 2003-06-19 | 2004-12-23 | Pfizer Products Inc. | Nk1 antagonist |
| CN101431996A (zh) | 2006-03-22 | 2009-05-13 | 加利福尼亚大学董事会 | 蛋白质异戊二烯基转移酶的抑制剂 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112574041A (zh) * | 2020-12-25 | 2021-03-30 | 温州大学新材料与产业技术研究院 | 一种手性β羟基1,3-二羰基类化合物的合成方法 |
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