CN101427993A - Prostaglandin microemulsion gel rubber preparation and method of producing the same - Google Patents
Prostaglandin microemulsion gel rubber preparation and method of producing the same Download PDFInfo
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- CN101427993A CN101427993A CNA2008102289044A CN200810228904A CN101427993A CN 101427993 A CN101427993 A CN 101427993A CN A2008102289044 A CNA2008102289044 A CN A2008102289044A CN 200810228904 A CN200810228904 A CN 200810228904A CN 101427993 A CN101427993 A CN 101427993A
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- Prior art keywords
- gel
- oil
- microemulsion
- preparation
- water
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- 238000002360 preparation method Methods 0.000 title claims abstract description 49
- 150000003180 prostaglandins Chemical class 0.000 title claims abstract description 17
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- 238000000034 method Methods 0.000 title abstract description 5
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- 229960000711 alprostadil Drugs 0.000 claims abstract description 35
- GMVPRGQOIOIIMI-DWKJAMRDSA-N prostaglandin E1 Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O GMVPRGQOIOIIMI-DWKJAMRDSA-N 0.000 claims abstract description 35
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 25
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- LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 claims description 5
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- JQWAHKMIYCERGA-UHFFFAOYSA-N (2-nonanoyloxy-3-octadeca-9,12-dienoyloxypropoxy)-[2-(trimethylazaniumyl)ethyl]phosphinate Chemical compound CCCCCCCCC(=O)OC(COP([O-])(=O)CC[N+](C)(C)C)COC(=O)CCCCCCCC=CCC=CCCCCC JQWAHKMIYCERGA-UHFFFAOYSA-N 0.000 claims description 3
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