CN101427918A - Magnetic resonance imaging method and uses thereof - Google Patents
Magnetic resonance imaging method and uses thereof Download PDFInfo
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- CN101427918A CN101427918A CNA2007100478390A CN200710047839A CN101427918A CN 101427918 A CN101427918 A CN 101427918A CN A2007100478390 A CNA2007100478390 A CN A2007100478390A CN 200710047839 A CN200710047839 A CN 200710047839A CN 101427918 A CN101427918 A CN 101427918A
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Abstract
The invention relates to the medical assay technology field, in particular to a magnetic resonance imaging method for monitoring tumor activity tissues after tumor therapy, which aims to effectively monitor residual or recrudescent tumor activity tissues in time by diffusion-weighted MR imaging (DWI), working out an individualized tumor therapeutic schedule which is reasonable and effective, and increasing curative effect and survival period of a patient. The provided imaging method is used for predicting tumor active ingredients through MR, and is a video picture method which indirectly reflects information such as tissue structure, cellular metergasis and the like through detecting the changes of water molecule motion state in biological tissues. The invention further provides concrete implementation parameters and steps for monitoring the tumor activity tissues after tumor therapy by adopting the magnetic resonance imaging method.
Description
Technical field
The present invention relates to medical detection technology, relate in particular to a kind of MR imaging method, and this method is monitored the application in the tumor promotion tissue behind oncotherapy.
Background technology
Malignant tumor is one of principal disease of harm humans health, and the active mass residual or recurrence of timely and effective monitoring tumor is the important leverage that improves the oncotherapy curative effect, prolongs patient's life cycle and life treatment behind the oncotherapy.The means of monitoring tumor efficiency clinically mainly are the methods of Medical Imaging, as CT (computer tomography, CT), MRI (MagneticResonance Imaging, MRI) and PET (positron emission tomography, PET) etc.Wherein CT strengthen to check it is a maximum technology of clinical practice, but since CT itself have radiation damage limited it repeat repeatedly use, CT imaging simultaneously organize resolution relatively low, also influenced the sensitivity of monitoring; The PET imaging has higher sensitivity, and the application of this respect is also arranged clinically, but its inspection fee costliness, and the current stage cannot popularization and application, and it organizes resolution and spatial resolution all low simultaneously.In recent years, Chinese scholars also is used to monitor the clinical value of the active mass of the residual of tumor or recurrence at research MRI, because nuclear magnetic resonance has advantages such as favorable tissue resolution, radiationless loss, particularly the Application and Development of some new techniques demonstrates the good potential quality of using in this regard.Wherein the diffusion-weighted imaging of magnetic resonance (DWI) is that change by hydrone kinestate in the detection of biological tissue reflects information such as organizational structure and cell function variation indirectly, has shown the potential quality that has aspect the prediction of tumor chemoradiotherapy curative effect and the EARLY STAGE EVALUATION.
Summary of the invention
The object of the present invention is to provide a kind of MR imaging method, and provide this method behind oncotherapy, to monitor application in the tumor promotion tissue.
The present invention utilizes the active mass of the residual of the timely and effective monitoring tumor of the diffusion-weighted imaging of magnetic resonance (DWI) or recurrence, formulates rational and effective tumor personalized therapy program, to improve patient's curative effect and life cycle.
The invention provides a kind of formation method of MR prediction tumor promotion composition, it is the developing method that reflects information such as organizational structure and cell function variation by the change of hydrone kinestate in the detection of biological tissue indirectly.Adopt the SE-EPI acquisition technique.
The concrete parameter of the diffusion-weighted imaging of magnetic resonance (DWI) is: 1.5T～3.0T magnetic resonance imager, ASSET proofreaies and correct, SE-EPI (single-shot echoplanar sequence) acquisition technique, sensitive factor b=300～800s/mm
2, direction ALL, TR time 4000～8000ms, TE time 60～80ms, bed thickness 5～7mm, 0.5～1mm at interval, the visual field (FOV) 26-28cm, matrix 512*512～256*256, times of collection 2～4 times, breath-hold scans, sweep time 24s～48s.
Above-mentioned MR imaging method is applied to judge tumor recurrence or residual activity tumor tissue behind the oncotherapy, carries out curative effect monitoring, and quantitative measurement tumor tissue ADC value, can effectively monitor the tumor treatment effect, improves patient's survival rate and life quality.The computational methods of apparent diffusion coefficient (ADC) are ADC=(ln[s
0/ s
1])/(b
1-b
0), wherein ln is a natural logrithm, b
0=0, b
1=300～800sec/mm
2, S
0And S
1Represent b respectively
0And b
1The time focus signal intensity.
The specific embodiment
Embodiment 1: the diffusion-weighted imaging of magnetic resonance (DWI) is followed up a case by regular visits to middle clinical practice in hepatocarcinoma through the Transarterial Chemoembolization postoperative: contrast with DSA
Method: hepatocarcinoma Transarterial Chemoembolization (transarterial chemoemblolization, TACE) patient's 16 examples, male's 14 examples wherein, women's 2 examples, age 23-78 year, The median age 59.5 years old.
DWI checks: 1.5T MR imager (GE company), and the soft body coil of 8 passage phased array, all patients make diffusion-weighted imaging (DWI).Main imaging parameters: ASSET proofreaies and correct, and SE-EPI gathers, b=0 and 500s/mm2, direction ALL, TR/TE6000ms/60ms, bed thickness 7mm, 0.5mm at interval, FOV 28cm, matrix 256*256, NEX 2, breath-hold scans, sweep time 24s.
Angiography (DSA) inspection method: under the guiding of Toshiba rotation Digital Subtraction blood vessel machine, all patients are all through the femoral artery approach, conventional row inguinal region preserved skin, sterilization, drape, local anesthesia point of puncture, after the success of Seldinger method puncture femoral artery, insert guiding wire and catheter sheath in turn, introduce Cook 5F RH pipe and select coeliac trunk or common hepatic artery radiography to observe the tumor staining situation.
Result: on DWI, observe the last time focus of capable TACE art, find that focus shows as the clutter based on high signal, internal signal is complicated, angiographic image contrasts during with focus signal and this interventional therapy, the control tumor focus is 18 altogether, wherein obviously tumor staining consistent (14/14) among the higher signaling zone in part, 14 focus marginal portions and the DSA on the DWI image, radiography show because of the iodized oil deposition be weary blood for the district on DWI for low signal or than low signal feature (15/15), radiography shows because of neoplasm necrosis is the dye-free district be low signal on DWI.
The weary blood of the last tumor low signal of conclusion: DWI district's representative is for the district, and high signaling zone represents blood for abundant tissue, the tumor tissues of promptly living.
Embodiment 2: (apparent diffusion coefficient ADC) strengthens the correlation research of checking maximum reinforcement value with CT to the tumor apparent diffusion coefficient
Method: hepatocarcinoma Transarterial Chemoembolization (transarterial chemoemblolization, TACE) patient's 16 examples, male's 14 examples wherein, women's 2 examples, age 23-78 year, The median age 59.5 years old.
DWI checks: 1.5T MR imager, and the soft body coil of 8 passage phased array, all patients make diffusion-weighted imaging (DWI).Main imaging parameters: ASSET proofreaies and correct, and SE-EPI gathers, b=0 and 500s/mm2, direction ALL, TR/TE 6000ms/60ms, bed thickness 7mm, 0.5mm at interval, FOV 26-28cm, matrix 256*256, NEX 2, breath-hold scans, sweep time 24s.
Epigastrium CT strengthens inspection method: use 16 slices spiral CT scanner units, and 120KV, 250mAs, pitch is 15, the frame rotational time is 0.5s, and the collection bed thickness is 1mm, and 7mm rebuilds bed thickness, 0.8mm strengthens and uses non-ionic contrast agent at interval, and consumption is pressed the 320mgI/kg body weight and calculated.Adopt the unidirectional injection of high pressure injector, speed 2.5～3.0ml/s, 20～30s sweeps the Hepatic artery phase after the ulnar vein injection, and 60～70s sweeps the portal vein phase, sweeps period of delay behind the 3min.
Measuring method: the DWI image is sent to work station, utilize the Functool analysis software, the ADC of analytical calculation focus, and it is unenhanced and strengthen each phase CT value of back to measure CT in corresponding aspect same area, calculates maximum reinforcement value=(maximum CT value after strengthening-plain CT value).Measurement requirement aspect correspondence, zone correspondence and size are corresponding.
The result: obtain 27 pairs of data altogether, (correlation analysis) analysed in credit by statistics, r=-0.81385, and P=0.0061＜0.05 can think that there are rectilinear correlation in CT maximum and ADC.
Conclusion: ADC and tumor tissues CT reinforcement value have certain dependency, can think that ADC can quantitatively evaluating active tumour tissue.
Claims (3)
1, a kind of MR imaging method, it is the developing method that reflects organizational structure and cell function change information by the change of hydrone kinestate in the detection of biological tissue indirectly, adopt the SE-EPI acquisition technique, it is characterized in that this method use 1.5T～3.0T magnetic resonance imager, concrete imaging parameters is: ASSET proofreaies and correct, sensitive factor b=300～800s/mm
2, direction ALL, TR time 4000～8000ms, TE time 60～80ms, bed thickness 5～7mm, 0.5～1mm at interval, visual field 26-28cm, matrix 512*512～256*256, times of collection 2～4 times, breath-hold scans, sweep time 24s～48s.
2, a kind of MR imaging method according to claim 1 is characterized in that concrete imaging parameters is: TR/TE6000ms/60ms, bed thickness 7mm, interval 0.5mm, visual field 28cm, matrix 256*256, times of collection 2 times.
3, a kind of MR imaging method as claimed in claim 1 or 2 application aspect tumor recurrence or the residual activity tumor tissue behind the monitoring oncotherapy.
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|---|---|---|---|
| CNA2007100478390A CN101427918A (en) | 2007-11-06 | 2007-11-06 | Magnetic resonance imaging method and uses thereof |
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| CNA2007100478390A CN101427918A (en) | 2007-11-06 | 2007-11-06 | Magnetic resonance imaging method and uses thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106249183A (en) * | 2016-09-24 | 2016-12-21 | 中国科学院武汉物理与数学研究所 | A kind of hyperpolarization xenon magnetic resonance method based on spectrum picture integration |
| CN109115820A (en) * | 2018-07-02 | 2019-01-01 | 清华大学 | The separation of magnetic resonance water rouge and quantitative approach and device based on Echo-plane imaging |
| CN109584995A (en) * | 2018-06-20 | 2019-04-05 | 新影智能科技(昆山)有限公司 | TACE treatment results image analysis method, system, equipment and storage medium |
-
2007
- 2007-11-06 CN CNA2007100478390A patent/CN101427918A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106249183A (en) * | 2016-09-24 | 2016-12-21 | 中国科学院武汉物理与数学研究所 | A kind of hyperpolarization xenon magnetic resonance method based on spectrum picture integration |
| CN106249183B (en) * | 2016-09-24 | 2018-10-12 | 中国科学院武汉物理与数学研究所 | One kind is based on spectrum as integrated hyperpolarization xenon magnetic resonance method |
| CN109584995A (en) * | 2018-06-20 | 2019-04-05 | 新影智能科技(昆山)有限公司 | TACE treatment results image analysis method, system, equipment and storage medium |
| CN109115820A (en) * | 2018-07-02 | 2019-01-01 | 清华大学 | The separation of magnetic resonance water rouge and quantitative approach and device based on Echo-plane imaging |
| CN109115820B (en) * | 2018-07-02 | 2020-03-24 | 清华大学 | Magnetic resonance water-fat separation and quantification method and device based on plane echo imaging |
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Open date: 20090513 |