CN101422568A - Shen flavor capsule capable of reducing blood sugar and preparation method thereof - Google Patents
Shen flavor capsule capable of reducing blood sugar and preparation method thereof Download PDFInfo
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- CN101422568A CN101422568A CNA2008101590161A CN200810159016A CN101422568A CN 101422568 A CN101422568 A CN 101422568A CN A2008101590161 A CNA2008101590161 A CN A2008101590161A CN 200810159016 A CN200810159016 A CN 200810159016A CN 101422568 A CN101422568 A CN 101422568A
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Abstract
The invention provides a hypoglycemic capsule with a taste of refs and a preparation method thereof; and the prescription is as follows: 30 to 240 portions of radix pseudostellariae, 30 to 240 portions of Radix Glehniae, 30 to 240 portions of tuber of dwarf lilyturf, 6 to 150 portions of schisandra chinensis, 30 to 240 portions of Chinese yam, 3 to 120 portions of coptis chinensis, 6 to 150 portions of radix rehmanniae, 30 to 240 portions of trichosanthin and 30 to 240 portions of rhizoma pollgonati, and the portions refer to the portions by weight. The hypoglycemic capsule with a taste of refs has the effects of nourishing qi to generate fluid and nourishing yin to clear away heat and has a good curative effect on diabetic ketosis in phrase II.
Description
Technical field the present invention relates to a kind of Chinese medicine preparation with blood sugar lowering effect, and relates to the preparation method of said preparation, and this Chinese medicine preparation mainly is applicable to II phase diabetes ketosis.
The existing blood sugar lowering apoplexy due to endogenous wind of background technology pharmacopoeia class is various, but traditional pharmaceutical technology program is simple, purification difficult, and medicine stability is poor, and bioavailability is low, and effective ingredient is difficult to determine, causes the herbal function of the type imprecise.Poor for treatment II phase diabetes ketosis specific aim, curative effect can not be satisfactory.
Summary of the invention the present invention aims to provide a kind of Shen flavor capsule capable of reducing blood sugar and preparation method thereof, in order to overcome the defective of existing procucts and preparation method, technical problem to be solved is: prepare a kind of supplementing QI for promoting the production of body fluid that has, the Shen flavor capsule capable of reducing blood sugar that is applicable to II phase diabetes ketosis of replenishing YIN and removing heat thereby by scientific and reasonable medicament prescription and pharmaceutical technology the effective ingredient in the Chinese medicine is extracted fully.
In order to solve the problems of the technologies described above, the present invention has adopted following technical scheme.
A kind of Shen flavor capsule capable of reducing blood sugar is characterized in that its prescription is: Radix Pseudostellariae 30--240 part, Radix Glehniae 30--240 part, Radix Ophiopogonis 30--240 part, Fructus Schisandrae Chinensis 6--150 part, Rhizoma Dioscoreae 30--240 part, Rhizoma Coptidis 3--120 part, Radix Rehmanniae 6--150 part, Radix Trichosanthis 30--240 part, Rhizoma Polygonati 30--240 part; Described part all refers to weight portion.
Preferred prescription is: Radix Pseudostellariae 60--240 part, Radix Glehniae 60--240 part, Radix Ophiopogonis 60--240 part, Fructus Schisandrae Chinensis 15--150 part, Rhizoma Dioscoreae 60--240 part, Rhizoma Coptidis 9--120 part, Radix Rehmanniae 15--150 part, Radix Trichosanthis 60--240 part, Rhizoma Polygonati 60--240 part.
Optimum prescription is: 172 parts of Radix Pseudostellariaes, 172 parts of Radix Glehniaes, 172 parts of Radix Ophiopogonis, 87 parts of Fructus Schisandrae Chinensis, 172 parts of Rhizoma Dioscoreaes, 51 parts of Rhizoma Coptidis, 87 parts of Radix Rehmanniae, 172 parts of Radix Trichosanthis, 172 parts of Rhizoma Polygonatis.
First kind of preparation method of described Shen flavor capsule capable of reducing blood sugar is characterized in that may further comprise the steps:
Behind the described nine flavor Chinese medicine pulverize separately, sieve, be mixed in proportion, add the adjuvant of Chinese medicine weight 0--30%, mixing; Granulate; Incapsulate.
Second kind of preparation method of described Shen flavor capsule capable of reducing blood sugar is characterized in that: described nine flavor Chinese medicines are mixed in proportion; Decoct with water more than 1 time or 1 time; Get decocting liquid, collecting decoction when decocting more than 1 time; Filter; Relative density was a 1.25-1.30 gram/cubic centimetre when filtrate was concentrated to 50 ℃; Auxiliary materials and mixing with Chinese medicine weight 0--30%; Dry; Pulverize; Sieve; Granulate; Incapsulate.
The third preparation method of described Shen flavor capsule capable of reducing blood sugar is characterized in that: take by weighing described nine flavor Chinese medicines 1), in proportion, wherein part pulverizing is standby, and all the other enter the 2nd) step;
2), the Chinese medicine of not pulverizing decocts with water more than 1 time or 1 time; Get decocting liquid, collecting decoction when decocting more than 1 time; Filter; Relative density was a 1.25-1.30 gram/cubic centimetre when filtrate was concentrated to 50 ℃;
3), with the 2nd) the extraction concentrated solution and the 1st in step) auxiliary materials and mixing of step pulverizing reserve piece and Chinese medicine weight 0--30%; Dry; Pulverize; Sieve; Granulate; Incapsulate.
Wherein the method for optimizing of the third preparation method is: in the described nine flavor Chinese medicines, get the Fructus Schisandrae Chinensis of 1/3rd amounts, be ground into fine powder, sieve, and standby; Eight flavors such as all the other Radix Pseudostellariaes decoct with water 2 times with the residue Fructus Schisandrae Chinensis, add 10 times of water gagings for the first time, decoct 2 hours, add 8 times of water gagings for the second time, decoct 1 hour; Collecting decoction; Filter, relative density was a 1.25-1.30 gram/cubic centimetre when filtrate was concentrated to 50 ℃; The adjuvant that adds Fructus Schisandrae Chinensis fine powder and Chinese medicine weight 0--30%, mixing; Dry; Pulverize; Sieve; Granulate; Incapsulate.
Good effect of the present invention is: this Shen flavor capsule capable of reducing blood sugar has supplementing QI for promoting the production of body fluid, the effect of replenishing YIN and removing heat.Diabetes to deficiency of both QI and YIN, dryness-heat being excessive in the interior is evident in efficacy.
The advantage of this preparation method is: this preparation is to research and develop to form on the basis of traditional decoction, preparation technology is main extracting method to add water heating decoction, can extract the effective ingredient of medicine fully, and capsule has the bad smell that can cover medicine, easily accepted by the patient; Can improve stability of drug; The bioavailability height, characteristics such as dispersion is fast, good absorbing reach better therapeutic.
Yantai Mouping TCM Hospital was from this preparation of beginning clinical practice in 2003.Treatment model case 154 examples, produce effects 100 examples, effective 149 examples, total effective rate reaches 96.75%, obvious effective rate 64.94%.
The specific embodiment further specifies the present invention below in conjunction with the specific embodiment.
[preparation embodiment]
Example one
172 parts of [prescription] Radix Pseudostellariaes, 172 parts of Radix Glehniaes, 172 parts of Radix Ophiopogonis, 87 parts of Fructus Schisandrae Chinensis, 172 parts of Rhizoma Dioscoreaes, 51 parts of Rhizoma Coptidis, 87 parts of Radix Rehmanniae, 172 parts of Radix Trichosanthis, 172 parts of Rhizoma Polygonatis.Described part all refers to weight portion.
[method for making] above nine flavors are got 87 parts of Fructus Schisandrae Chinensis, are ground into fine powder, sieve, and are standby; Eight flavors such as all the other Radix Pseudostellariaes decoct with water 2 times, add 10 times of water gagings for the first time, decoct 2 hours, for the second time add 8 times of water gagings, decocted collecting decoction 1 hour, filter, it is 1.25 gram/cubic centimetres (50 ℃) that filtrate is concentrated into relative density, adds the adjuvant dextrin of Fructus Schisandrae Chinensis fine powder and Chinese medicine weight 15%, mixing, drying is crushed to 120 orders, sieve, granulate, incapsulate, promptly.
Example two
240 parts of [prescription] Radix Pseudostellariaes, 240 parts of Radix Glehniaes, 240 parts of Radix Ophiopogonis, 150 parts of Fructus Schisandrae Chinensis, 240 parts of Rhizoma Dioscoreaes, 120 parts of Rhizoma Coptidis, 150 parts of Radix Rehmanniae, 240 parts of Radix Trichosanthis, 240 parts of Rhizoma Polygonatis.
[method for making] above nine flavors are got 100 parts of Radix Pseudostellariaes, 120 parts of Radix Ophiopogonis, are ground into fine powder, sieve, and mixing, standby; Seven flavors such as all the other Radix Glehniaes decocted with water 2 times with residue Radix Pseudostellariae, Radix Ophiopogonis, added 10 times of water gagings for the first time, decocted 2 hours, for the second time add 8 times of water gagings, decocted collecting decoction 1 hour, filter, it is 1.30 gram/cubic centimetres (50 ℃) that filtrate is concentrated into relative density, adding Radix Pseudostellariae, Radix Ophiopogonis the fine powder mixing, dry, be crushed to 80 orders, sieve, granulate, incapsulate, promptly.
Example three
30 parts of [prescription] Radix Pseudostellariaes, 30 parts of Radix Glehniaes, 30 parts of Radix Ophiopogonis, 6 parts of Fructus Schisandrae Chinensis, 30 parts of Rhizoma Dioscoreaes, 3 parts of Rhizoma Coptidis, 6 parts of Radix Rehmanniae, 30 parts of Radix Trichosanthis, 30 parts of Rhizoma Polygonatis.
[method for making] decocts with water above nine flavor medical materials 2 times, adds 10 times of water gagings for the first time, decocts 2 hours, for the second time add 8 times of water gagings, decocted collecting decoction 1 hour, filter, it is 1.27 gram/cubic centimetres (50 ℃) that filtrate is concentrated into relative density, adds the starch of Chinese medicine weight 30%, mixing, drying is crushed to 100 orders, sieve, granulate, incapsulate, promptly.
Example four
70 parts of [prescription] Radix Pseudostellariaes, 50 parts of Radix Glehniaes, 100 parts of Radix Ophiopogonis, 20 parts of Fructus Schisandrae Chinensis, 90 parts of Rhizoma Dioscoreaes, 50 parts of Rhizoma Coptidis, 30 parts of Radix Rehmanniae, 80 parts of Radix Trichosanthis, 200 parts of Rhizoma Polygonatis.
[method for making] above nine flavor Chinese medicine pulverize separately become fine powder to 120 order, sieve, and mixing, the adjuvant dextrin of adding Chinese medicine weight 20%, mixing is granulated, and incapsulates, promptly.
[character] this product is a capsule, and content is granule and the powder of sepia to brownish black, bitter in the mouth.
This product content 5g is got in [discriminating] (1), adds chloroform 20ml, and reflux 30 minutes filters, and filtrate evaporate to dryness, residue add chloroform 1ml makes dissolving, as need testing solution.Other gets Fructus Schisandrae Chinensis control medicinal material 1g, shines medical material solution in pairs with legal system.Test according to thin layer chromatography (an appendix VI of Chinese Pharmacopoeia version in 2005 B), draw each 5 μ l of above-mentioned two kinds of solution, put respectively on same silica GF254 lamellae, upper solution with petroleum ether (30～60 ℃)-Ethyl formate-formic acid (15:5:1) is developing solvent, launch, take out, dry, put under the ultra-violet lamp (254nm) and inspect.In the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show the principal spot of same color.
(2) get this product content 2g, add methanol 10ml, reflux 15 minutes filters, and filtrate is as need testing solution.Other gets Rhizoma Coptidis control medicinal material 0.5g, shines medical material solution in pairs with legal system.Test according to thin layer chromatography (an appendix VI of Chinese Pharmacopoeia version in 2005 B), draw each 1 μ l of above-mentioned three kinds of solution, put respectively on same silica gel g thin-layer plate, with benzene-ethyl acetate-isopropyl alcohol-methanol-water (6:3:1.5:1.5:0.3) is developing solvent, put in the expansion cylinder of ammonia saturated with vapor, launch, take out, dry, put under the ultra-violet lamp (365nm) and inspect.In the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show identical yellow fluorescence principal spot.
[inspection] should meet every regulation relevant under the capsule item (appendix IL of Chinese Pharmacopoeia version in 2005).
[extractum] gets the about 2g of this product content, porphyrize, and accurate the title, decide, and measures according to the hot dipping (appendix XA of Chinese Pharmacopoeia version in 2005) under the ethanol-soluble extractives algoscopy item, makes solvent with ethanol.Every of this product contains ethanol-soluble extractives must not be less than 50mg.
[function with cure mainly] supplementing QI for promoting the production of body fluid, replenishing YIN and removing heat.Cure mainly the diabetes of deficiency of both QI and YIN, dryness-heat being excessive in the interior.Disease is seen weak, and xerostomia is thirsty, diseases such as polyuria, tongue fur BOHUANG, thready and weak pulse or count accurately.Be applicable to II phase diabetes ketosis person.
[usage and consumption] is oral, one time 6,2-3 time on the one.
[specification] 0.40g/ grain.
Shady and cool place is put in [storage] sealing.
Claims (7)
1, a kind of Shen flavor capsule capable of reducing blood sugar is characterized in that its prescription is: Radix Pseudostellariae 30--240 part, Radix Glehniae 30--240 part, Radix Ophiopogonis 30--240 part, Fructus Schisandrae Chinensis 6--150 part, Rhizoma Dioscoreae 30--240 part, Rhizoma Coptidis 3--120 part, Radix Rehmanniae 6--150 part, Radix Trichosanthis 30--240 part, Rhizoma Polygonati 30--240 part; Described part all refers to weight portion.
2, Shen flavor capsule capable of reducing blood sugar as claimed in claim 1, it is characterized in that its prescription is: Radix Pseudostellariae 60--240 part, Radix Glehniae 60--240 part, Radix Ophiopogonis 60--240 part, Fructus Schisandrae Chinensis 15--150 part, Rhizoma Dioscoreae 60--240 part, Rhizoma Coptidis 9--120 part, Radix Rehmanniae 15--150 part, Radix Trichosanthis 60--240 part, Rhizoma Polygonati 60--240 part.
3, Shen flavor capsule capable of reducing blood sugar as claimed in claim 2 is characterized in that its prescription is: 172 parts of Radix Pseudostellariaes, 172 parts of Radix Glehniaes, 172 parts of Radix Ophiopogonis, 87 parts of Fructus Schisandrae Chinensis, 172 parts of Rhizoma Dioscoreaes, 51 parts of Rhizoma Coptidis, 87 parts of Radix Rehmanniae, 172 parts of Radix Trichosanthis, 172 parts of Rhizoma Polygonatis.
4, as the preparation method of claim 1 or 2 or 3 described Shen flavor capsule capable of reducing blood sugar, it is characterized in that may further comprise the steps: behind the described nine flavor Chinese medicine pulverize separately, sieve, be mixed in proportion, add the adjuvant of Chinese medicine weight 0--30%, mixing; Granulate; Incapsulate.
5, as the preparation method of claim 1 or 2 or 3 described Shen flavor capsule capable of reducing blood sugar, it is characterized in that may further comprise the steps: described nine flavor Chinese medicines are mixed in proportion; Decoct with water more than 1 time or 1 time; Get decocting liquid, collecting decoction when decocting more than 1 time; Filter; Relative density was a 1.25-1.30 gram/cubic centimetre when filtrate was concentrated to 50 ℃; Auxiliary materials and mixing with Chinese medicine weight 0--30%; Dry; Pulverize; Sieve; Granulate; Incapsulate.
6, as the preparation method of claim 1 or 2 or 3 described Shen flavor capsule capable of reducing blood sugar, it is characterized in that may further comprise the steps:
1) take by weighing described nine flavor Chinese medicines, in proportion, wherein part pulverizing is standby, and all the other enter the 2nd) step;
2), the Chinese medicine of not pulverizing decocts with water more than 1 time or 1 time; Get decocting liquid, collecting decoction when decocting more than 1 time; Filter; Relative density was a 1.25-1.30 gram/cubic centimetre when filtrate was concentrated to 50 ℃;
3), with the 2nd) the extraction concentrated solution and the 1st in step) auxiliary materials and mixing of step pulverizing reserve piece and Chinese medicine weight 0--30%; Dry; Pulverize; Sieve; Granulate; Incapsulate.
7, the preparation method of Shen flavor capsule capable of reducing blood sugar as claimed in claim 6 is characterized in that:
In the described nine flavor Chinese medicines, get the Fructus Schisandrae Chinensis of 1/3rd amounts, be ground into fine powder, sieve, standby; Eight flavors such as all the other Radix Pseudostellariaes decoct with water 2 times with the residue Fructus Schisandrae Chinensis, add 10 times of water gagings for the first time, decoct 2 hours, add 8 times of water gagings for the second time, decoct 1 hour; Collecting decoction; Filter, relative density was a 1.25-1.30 gram/cubic centimetre when filtrate was concentrated to 50 ℃; The adjuvant that adds Fructus Schisandrae Chinensis fine powder and Chinese medicine weight 0--30%, mixing; Dry; Pulverize; Sieve; Granulate; Incapsulate.
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2008101590161A CN101422568A (en) | 2008-11-18 | 2008-11-18 | Shen flavor capsule capable of reducing blood sugar and preparation method thereof |
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| CNA2008101590161A CN101422568A (en) | 2008-11-18 | 2008-11-18 | Shen flavor capsule capable of reducing blood sugar and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102716342A (en) * | 2012-06-30 | 2012-10-10 | 高秀香 | Medicine for treating diabetes |
| CN102764367A (en) * | 2012-07-17 | 2012-11-07 | 遵义臻坤中草医药研究所 | Medicine composition for treating diabetes mellitus and complications |
| CN108404048A (en) * | 2018-04-28 | 2018-08-17 | 李太平 | A kind of formula of hypoglycemic body health ball |
| CN114177249A (en) * | 2021-12-17 | 2022-03-15 | 北京御鑫堂中医研究院 | Fermented traditional Chinese medicine formula for treating diabetes |
-
2008
- 2008-11-18 CN CNA2008101590161A patent/CN101422568A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102716342A (en) * | 2012-06-30 | 2012-10-10 | 高秀香 | Medicine for treating diabetes |
| CN102716342B (en) * | 2012-06-30 | 2014-07-09 | 高秀香 | Medicine for treating diabetes |
| CN102764367A (en) * | 2012-07-17 | 2012-11-07 | 遵义臻坤中草医药研究所 | Medicine composition for treating diabetes mellitus and complications |
| CN108404048A (en) * | 2018-04-28 | 2018-08-17 | 李太平 | A kind of formula of hypoglycemic body health ball |
| CN114177249A (en) * | 2021-12-17 | 2022-03-15 | 北京御鑫堂中医研究院 | Fermented traditional Chinese medicine formula for treating diabetes |
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Open date: 20090506 |