CN101415485A

CN101415485A - Micro-reactor system

Info

Publication number: CN101415485A
Application number: CNA2007800122365A
Authority: CN
Inventors: 多米尼克·罗贝热; 尼古拉斯·比勒尔; 伯廷·齐默尔曼; 赖纳德·福伯特
Original assignee: Lonza AG
Current assignee: Lonza AG
Priority date: 2006-03-31
Filing date: 2007-03-29
Publication date: 2009-04-22
Anticipated expiration: 2027-03-29
Also published as: CN101415485B

Abstract

A micro-reactor system assembly comprises a stack of at least n process modules (1-6), wherein n is an integer equal to or greater than 1, made from a rigid first material and comprising at least one reactive fluid passage (1A, 1B, 2A, 3A, 6A) for accommodating and guiding a reactive fluid, and at least n+1 heat exchange modules (7, 8) made from a ductile second material other than said first material and comprising at least one heat exchange fluid passage (7A, 8A) for accommodating and guiding a heat exchange fluid, wherein each process module (1-6) is sandwiched between two adjacent heat exchange modules (7, 8).

Description

Micro-reactor system

Technical field

The present invention relates to micro-reactor system, it comprises at least n processing module and n+1 heat exchange module at least, and wherein each processing module is sandwiched between two adjacent heat exchange modules.

Background technology

Microreactor is a reaction unit, it is used for one or more reactant reactions (mixture that comprises two or more reactants usually), and be used for to a certain extent by before mixing, mix and/or mix the reaction that described reactant is controlled in back heating or cooling or the described reactant of heat buffering.The microreactor that is used for realization chemical reaction in the zonule like this can be known from for example EP-A-0688242, EP-A-1031375, WO-A-2004/045761 and US-A-2004/0109798.

The chemical reaction that carries out in microreactor can be divided into so-called A type reaction and Type B reaction basically.

A type reaction, organometallic reaction for example is very fast chemical reaction and directly take place during mixed reactant in mixing chamber, usually in 1 second scope.They can be called as the reaction by mixed processing control.In order to allow all reactant complete reactions and for fear of accessory substance, such A type reaction requires to handle mixing fast and effectively of fluid, and effectively thermal control.Such A type reaction requires not have or the very short afterreaction time usually, and therefore can realize well in the microreactor with little resident volume or afterreaction volume.For the residence time of this class reaction usually in less than 20 seconds scope.

On the contrary, Type B reaction, the acetyl acylation reaction of Wittig reaction (Wittig reaction) or aromatic amine and diketene (diktene) for example, faster or slower, the common reaction time is in the scope in 1 second to 10 minute.They are subjected to concentration or dynamics Controlling and carry out.In order to make reactant reaction fully and avoid accessory substance, this class Type B reaction does not require this reactant of very fast mixing, and requires can control in entire reaction time internal reaction condition.Therefore, the size of resident volume and afterreaction volume must so be set, and promptly can easily and handle fluid under the condition of accurately control in this microreactor maintenance for a long time.Yet, because the little and expensive micro-structural of size up to now, realizes that with traditional microreactor so long residence time is difficult.Therefore, traditional microreactor major part is used for the reaction of A type.

Summary of the invention

Therefore, the purpose of this invention is to provide improved micro-reactor system, it is suitable for guaranteeing required residence time, and temperature control is possible in this residence time.

This purpose is solved by micro-reactor system according to claim 1, and it comprises following storehouse:

At least n processing module (1-6), wherein n is equal to or greater than 1 integer.Each processing module (1-6) is made by first material of rigidity, and comprise at least one reacting fluid passage (1A, 1B, 2A, 3A, 6A), this reacting fluid passage passes described processing module (1-6), and between at least one reacting fluid inlet port (1C, 1D, 2C, 2D, 3C, 6C) and at least one reacting fluid outlet (1E, 1F, 2E, 3D, 6D), be used to hold and guide reacting fluid.Wherein, under the situation that at least two processing modules (1-6) arranged, connect on described at least two processing modules (1-6) function; And

At least n+1 heat exchange module (7,8), its second material by deformable that is different from described first material or flexible is made, and comprise at least one heat-exchange fluid passage (7A, 8A), this heat-exchange fluid passage passes described heat exchange module (7,8) inside, and between its at least one heat-exchange fluid inlet port (7B, 8B) with at least one heat-exchange fluid outlet (7C, 8C), be used to hold and guide heat-exchange fluid, the wherein said heat exchange module of n+1 at least (7,8) connect on the function

Wherein each processing module (1-6) is sandwiched between two adjacent heat exchange modules (7,8).

This is n processing module and this n+1 each self-forming of heat exchange module module independently at least at least, it limits at least one fluid passage, be reacting fluid passage or heat-exchange fluid passage, extend fully the inside of the module between this at least one inlet port and this at least one outlet.

By processing module and the heat exchange module of being made by different materials is provided, being respectively this processing module and heat exchange module, to select following first and second materials be possible:

For this processing module, can select reaction to this reactant, especially first material anticorrosive and/or resistance to compression is best, and preferably be selected from the group that comprises stainless steel, nickel-base alloy, tungsten, tantalum, titanium, pottery, silicon, graphite and/or the appropriate combination of one or more described first materials.

For this heat exchange module, can select second material of flexible, it is to heat transmission and/or sealing, and especially hot conduction is best, and preferably is selected from the group that comprises aluminium, aluminium alloy, copper, copper alloy, silver and silver alloy and/or the appropriate combination of one or more described second materials.

So, have the processing module separately and the micro-reactor system of heat exchange module by providing, at its certain responsibilities, promptly carry out this chemical reaction or control treatment temperature, each described module of optimization becomes possibility.

Advantageously, provide independent module respectively, allow element standardization this micro-reactor system to this chemical reaction processing and the control of this temperature.Therefore, have different residence times for differential responses provide, different fluid volume, the different different micro-reactor system that shifts heats or the like become possibility.For example, provide heat exchange module, allow to same processing module supply or remove more heats with the more major path that is used to hold heat-exchange fluid.

This first material is rigidity relatively, and this second material compares flexible.Preferably, be used for second material reversibly (promptly flexibly) or residual (remainingly) (being plasticity) distortion under pressure of the flexible of this heat exchange module.With heat exchange module be pressed in adjacent, by on the processing module of making as comparison rigidity first materials such as stainless steels, the contact-making surface of this heat exchange module is out of shape a little, thereby does not need extra sealing between processing module and the heat exchange module.

Compare with traditional microreactor (wherein in order to provide good heat transfer process fluid and the wall thickness between the heat-exchange fluid to reduce as far as possible),, provide independently processing module and heat exchange module according to the present invention.Although this has increased the distance (before this, this is considered to disadvantageous) between reacting fluid and the heat-exchange fluid, owing to the certain responsibilities about them makes these standalone module optimizations, can reach better processing and temperature control surprisingly.

Each processing module is sandwiched between two heat exchange modules, and each heat exchange module that is not placed on the end of this microreactor is sandwiched between two processing modules.Heat exchange module in this micro-reactor system end can be placed on respectively between first, second frame mounting and the processing module.

According to the preferred embodiment of this micro-reactor system, the described processing module of n at least comprises:

Mixing module, its at least one reacting fluid passage comprises the mixing portion that is used to receive and mix at least two kinds of reacting fluids; And alternatively

At least one thermal conditioning module is arranged on the upstream of described mixing module, is used for adjusting before entering described mixing module the temperature of described reacting fluid; And

At least one keeps module, is arranged on the downstream of this mixing module, is used to hold this reacting fluid mixture.

Use allows continuous reactions steps is introduced more reacting fluids continuously more than a mixing module.At described mixing module, this reacting fluid mixes in the mixing portion of a part that constitutes this at least one reacting fluid passage, and leave after the described mixing portion, be accommodated in first the keeping in the volume an of part of this at least one reacting fluid passage of same formation.Described mixing portion can have as plug flow to be mixed or the combination construction of reverse mixing, and described first keep volume can comprise the straight passage of one or more cardinal principles that is connected by bend pipe.Preferably, provide maintenance to produce first of laminar flow and hold volume.

The temperature of the reacting fluid in this mixing module can be by two the heat exchange module controls adjacent with described mixing module.There, heat or cold heat-exchange fluid be provided at these two heat exchange modules this at least one heat-exchange fluid passage in each, it is by heat transmission supply or remove heat from this processing module.

As top pointed, before mixing two or more reacting fluids, described reacting fluid can be heated or cooled.In addition, can provide one or more thermal conditioning modules in the upstream of described mixing module.Reacting fluid to be heated for each or cool off, described thermal conditioning module comprises at least one reacting fluid passage.When flowing through described reacting fluid passage, each reacting fluid is by adjacent with described thermal conditioning module two heat exchange modules heating or cooling, similar before to the description of this mixing module.By different channel volume is provided, heats discriminatively or cool off this different reactant and become possibility.

After leaving this mixing module, the reacting fluid of this mixing can be accommodated in one or more maintenance modules.There, the reacting fluid mixture that leaves this mixing module enters at least one the reacting fluid passage in this maintenance module, and described at least one the reacting fluid passage of flowing through leaves this maintenance module then.In described at least one the reacting fluid passage process of flowing through, with with mix about this before and the identical mode of description of heat exchange module, described reacting fluid mixture can be cushioned by two heat exchange modules heating, cooling or the heat adjacent with each holding module.The difference of (differenctly formed) the reacting fluid passage that has difformity by providing keeps module, obtains the different conservation conditions possibility that becomes.It also is possible that two or more maintenance modules that are connected with each other are provided, each keeps module to be sandwiched between the heat exchange module, thereby can obtain big maintenance volume and (depend on flow velocity) thus to obtain the big retention time (residence time) under this condition, especially the temperature of this reacting fluid mixture can be controlled in residence time easily and accurately.

Preferably, this processing module be used to hold and guide the reacting fluid passage of reacting fluid to comprise flat passage (flat channel).Ideally, this flow path of microreactor is narrow pipe, and its diameter is usually less than 1mm.Yet, stratiform non-turbulent flow if desired, this flow velocity is limited by described small bore (section).In order to increase flow velocity, can provide a plurality of so narrow pipes.But there, the stoichiometry in all pipes must be controllable, and for all pipes, this residence time must be controlled to be identical, and this can not extremely guarantee in the system of reality.

As preferred embodiment propose this flat passage, be equivalent to the combination of parallel pipe.Therefore flow velocity can be enlarged markedly, and keeps the stratiform non-turbulent flow simultaneously.

The result proves that the ratio of width to height is suitable for bringing forth good fruit in the 1:50 scope at 1:4.Preferably, described wide/height ratio is set at 1:4 in the 1:30 scope.More preferably, described wide/height ratio is set at 1:5 in the 1:25 scope.In an exemplary embodiment, be the width of this flat channel selecting 2.0mm, the height of 10mm and the length of 1844mm, produce wide/height ratio of 1:5.In a further embodiment, width after testing is chosen as 1.4mm, 0.9mm and 0.5mm respectively, produces wide/height ratio of 1:7.14,1:11.11 and 1:20 respectively.

Because the processing fluid major part in the minute widths of this passage, single tube can be kept laminar flow, and this flow velocity (handling the volume of fluid in the unit interval) increases simultaneously.And, in the preferred embodiment, only must control the stoichiometry in the single volume.

For indicate before, promptly have the passage of 2.0mm, 1.4mm, 0.9mm and 0.5mm width respectively, recorded that residence time was respectively 5.7,10.2,15.9 and 22.6 seconds under the flow velocity of 100ml/min.From above-mentioned measurement as can be known,, carry out combination, almost can select this residence time arbitrarily by the different module that will have different residence times for specific little reaction.Especially can obtain nearly 30 minutes residence time, or preferably reach 20 minutes, more preferably reach 10 minutes.

In a preferred embodiment, this micro-reactor system comprises the processing module of at least two series connection, and each is sandwiched between two adjacent heat exchange modules.For example, one or more mixing modules can with the thermal conditioning module combinations before at least one, be used for before mixing, this reacting fluid being transferred to optimum temperature, and/or at least one keeps module, be used to this reacting fluid mixture that required residence time is provided.During mixing and keeping, this adjacent heat exchange module control of module can be mixed and be kept to the temperature of this reacting fluid mixture with each.Alternatively, the auxiliary mixing module of the thermal conditioning module before having can be combined in two and keep between the modules, with by supplying with the carrying out that further reacting fluid allows subsequent reactions.

The reacting fluid passage of two processing modules subsequently can outsidely connect.There, can use outside dismountable or be fixedly coupled device (coupling) as pipe, accessory etc.Especially, pipe can be soldered or be welded to these modules, perhaps can use swagelok snap joint connector.Although dismountable aerial lug can be reused individual module easily and therefore improved flexibility, fixing pipe has advantageously been avoided dead space volume (deadvolume) and can have been increased the stability of whole micro-reactor system extraly.

Preferably, at least one heat-exchange fluid passage of in heat exchange module this comprises at least one heat-exchange fluid inlet port, it is connected with the first heat-exchange fluid holder or at least one heat-exchange fluid interface channel of providing in adjacent processing module, and at least one heat-exchange fluid outlet, it is connected with the second heat-exchange fluid holder or the heat-exchange fluid interface channel that provides in adjacent processing module.Therefore, two heat exchange modules a processing module is clipped in the middle can be connected with each other logical by this at least one the heat-exchange fluid interface channel that is provided in this processing module.Advantageously, between described two heat exchange modules, do not need extra heat-exchange fluid connector.

If described heat exchange module is made by the material of flexible, and be compressed against on this processing module, because the slight plasticity or the strain of the contact-making surface of this heat exchange module, do not need extra sealing at the interface place of this at least one heat-exchange fluid interface channel of the processing module by connecting two adjacent heat exchange modules.Yet, in a further advantageous embodiment, interface place at heat-exchange fluid inlet port and/or heat-exchange fluid outlet, extra seal can be provided, auxiliary seal is somebody's turn to do the heat-exchange fluid connector interface between two continuous heat exchange modules, and it passes the heat exchange module that this is clipped in the middle via this at least one heat-exchange fluid interface channel.Such sealing preferably can be lip ring.Especially, the rigid seal made such as its special teflon of can serving as reasons.Because this heat exchange module is made by the material of flexible, it is possible using rigid seal, avoids using elastic sealing element such as the rubber or the silicon etc. that may become fragile like this.

This of heat exchange module at least one hold the heat-exchange fluid passage of this heat-exchange fluid can be for producing (height) turbulent flow of described heat-exchange fluid, this helps increasing the heat transmission from heat exchange module to this adjacent processing module.Preferably, realize that Reynolds number is equal to or greater than 2600.

In a preferred embodiment, by first dull and stereotyped being connected to each other with second flat board made processing module.At the contact-making surface of described first and second flat boards, can be provided for holding this at least one reacting fluid passage of at least one reacting fluid by modes such as milling, etchings.Preferably, described at least one reacting fluid passage is a micro-structural.After described first and second flat boards being connected to each other by soldering, sintering, welding etc., except this at least one reacting fluid inlet port and this at least one reacting fluid outlet, this at least one the reacting fluid passage that is used to hold this reacting fluid is wrapped in this processing module fully.

Be provided for holding at least one heat-exchange fluid passage of at least one heat-exchange fluid by one or two contact-making surface at first and second flat boards, heat exchange module can be made similarly, first and second dull and stereotyped the linking together by soldering, welding etc. afterwards.Perhaps, middle flat board can be sandwiched between described first and second flat boards, and described middle flat board comprises one or more cuttings (cut-out).After described first, middle and second flat board be connected to each other, described cutting defined at least one the heat-exchange fluid passage that is used to hold at least one heat-exchange fluid with the corresponding surface of described first and second flat boards.

The externally combination of processing module of Lian Jieing and the heat exchange module that is connected in inside provides the preferred plan that is used for this at least one reacting fluid loop and this at least one heat exchange flow body loop are separated and avoid cross pollution.

In a preferred embodiment, by at least the first and second frame mountings, the storehouse of processing module and heat exchange module is pressed against each other.There, by one or more pulling force anchors or pull bar, described first and second frame mountings can be drawn toward each other, thus this processing module and heat exchange module are pressed between two frame mountings mutually.

In a preferred embodiment, each described frame mounting comprises inside and outside framework alternatively.In further preferred embodiment according to Figure 17, a frame mounting is made up of structural detail, and second frame mounting form by outside and inner frame, wherein this first frame mounting directly is anchored on this external frame by pull bar, and described external frame is pushed against described inner frame this first frame mounting and is positioned on the middle module stack.

Can provide described pull bar at the center and/or the edge of this micro-reactor system.So, described modularization micro-reactor system can easily be assembled into the module with different numbers.

Advantageously, provide cavity (cavity) in the central area of this first and second frame mounting, thereby when described first and second frame mountings of promotion were close each other, the circumferential section of these modules obtained higher pressure.This helps increasing the sealing characteristics of this microreactor.

In most preferred embodiment, a heat exchange module serves as the adjacent modules of two continuous processing modules,, in this micro-reactor system, provides heat exchange module and processing module in an alternating manner that is.Advantageously, this storehouse starts from and ends at heat exchange module.If two Continuous Heat Switching Modules interconnect by the heat-exchange fluid interface channel that is provided in to be clipped in the processing module therebetween, just can use the identical in structure heat exchange module, wherein each second module is rotated (the rich longitudinal axis 180 degree rotations of about 180 degree, if this heat-exchange fluid of supposition flows from right to left), thus this at least one outlet of this first heat exchange module, be provided at this at least one the heat-exchange fluid interface channel in this adjacent processing module, and this at least one heat-exchange fluid inlet port of this second heat exchange module subsequently is aligned with each other.

At least one heat-exchange fluid outlet of this of this at least one heat-exchange fluid inlet port of the heat exchange module that begins most of whole microprocessor system assembly and last heat exchange module, can communicate with the first and second heat-exchange fluid holders respectively, thereby this heat-exchange fluid flows to this second holder from this first holder, vice versa, heats thus, cools off or hot this processing module that cushions this micro-reactor system.There, in abutting connection with this first with this first and second frame mounting of last heat exchange module in inlet port and outlet can be provided respectively.

Can provide extra heat-exchange fluid inlet port and heat-exchange fluid outlet at the heat exchange module that is positioned at this microreactor, its with the 3rd, heat-exchange fluid holder such as the fourth class communicates.So for example Re first heat-exchange fluid can flow to the 3rd holder through the heat exchange module that this thermal conditioning module is clipped in the middle from this first holder, heat the reactant of the thermal conditioning module of flowing through thus.So, the second cold heat-exchange fluid can flow to this second holder through the heat exchange module that this maintenance module is clipped in the middle from the 4th holder, thus this processing fluid of cooling in residence time.

As mentioned above, in a preferred embodiment, continuous heat exchange module is identical substantially, wherein each second module is rotated about 180 degree, thereby this at least one heat-exchange fluid outlet of this first heat exchange module, is provided at this at least one heat-exchange fluid interface channel in this adjacent processing module and this at least one heat-exchange fluid inlet port of this second adjacent heat exchange module is communicated with each other.Therefore this heat-exchange fluid with the zigzag linear flow through this microreactor.The quantity that depends on processing module and heat exchange module for inlet port and outlet with whole microreactor adapt, is necessary to provide two heat exchange modules adjacent one another are.For fear of described two adjacent heat exchange modules, can they be separated by one blind (blind module) is set.Perhaps, for example, this second frame mounting (outlet of this microreactor can be provided in it) can be rotated about 180 degree (rich trunnion axis 180 degree rotations suppose that this heat-exchange fluid flows from right to left) and be complementary with the outlet with this last heat exchange module.Perhaps, for example, can use second frame mounting of (shifted) inlet port that has displacement.

Further purpose, advantage and feature can obtain from dependent claims and described embodiments of the invention.In addition:

Description of drawings

Fig. 1 shows that all accessories are at the stereogram of the micro-reactor system of a side according to one embodiment of the invention;

Fig. 2 shows the stereogram of this micro-reactor system Rotate 180 degree shown in Figure 1;

Fig. 3 shows the front cross sectional view of the thermal conditioning module of this micro-reactor system shown in Figure 1;

Fig. 4 shows this thermal conditioning module of seeing Fig. 3 from the left side;

Fig. 5 shows the front cross sectional view of the mixing module of this micro-reactor system shown in Figure 1;

Fig. 6 shows among Fig. 5 the enlarged drawing in the upper left corner that is designated " X ";

Fig. 7 shows the front cross sectional view of maintenance (the keeping retention) module of this micro-reactor system among Fig. 1;

Fig. 8 shows the vertical view cutaway drawing of seeing this mixing module of Fig. 7 from above;

Fig. 9 shows the enlarged drawing of the reacting fluid inlet port of this mixing module shown in Figure 8;

Figure 10 shows the front cross sectional view of another maintenance module of this microreactor among Fig. 1;

Figure 11 shows the vertical view cutaway drawing of seeing this mixing module of Figure 10 from above;

Figure 12 shows the enlarged drawing of reacting fluid inlet port of this mixing module of Figure 10;

Figure 13 shows the front cross sectional view of first heat exchange module;

Figure 14 shows the side sectional view of the heat exchange module of Figure 13;

Figure 15 shows the front cross sectional view of second heat exchange module;

Figure 16 shows the side sectional view of the heat exchange module of Figure 15; And

Figure 17 shows the vertical section of micro-reactor system according to an embodiment of the invention.

The specific embodiment

This micro-reactor system according to an embodiment of the invention, as shown in Figures 1 and 2, comprise first frame mounting 10, first heat exchange module 7, thermal conditioning module 1, second heat exchange module 8, mixing module 2, another first heat exchange module 7, the maintenance module 3 of regarding other processing module as, another second heat exchange module 8, the

other maintenance module

4,5 and 6 (each is sandwiched in respectively between two heat exchange modules 7,8) and second frame mounting 9 in turn as another processing module as processing module.Like this, between described first and

second frame mountings

10,9, provide first or second

heat exchange module

7,8 and the processing module 1-6 alternately.

Can be clear that from Figure 14,16 each

heat exchange module

7,8 comprises the first dull and stereotyped 7M, 8M respectively, middle dull and stereotyped 70, the 80 and second dull and stereotyped 7N, 8N, they connect together by soldering.This centre flat board comprises the pattern of parallel straight channel form, and wherein two passages are connected by semi-ring in succession, so that form a continuous sinusoidal pattern.The described pattern of this centre dull and stereotyped 70,80 thus respectively and this surface, inside of this first and second dull and stereotyped 7M, 7N and 8M, 8N limit heat-exchange fluid passage 7A, 8A and be used to hold heat-exchange fluid in this heat exchange module 7,8.End at this pattern, through hole is formed at this first dull and stereotyped 7M, 8M, and at the relative end of this pattern, another through hole is formed at this second dull and stereotyped 7N, 8N, thereby define heat-exchange fluid inlet port 7B, 8B and heat-exchange fluid outlet 7C, 8C respectively, they communicate with this heat-exchange fluid passage 7A, 8A.

From Figure 13-16 as can be seen, this first and second

heat exchange module

7,8 is identical substantially, and wherein this second heat exchange module 8 is rotated about 180 degree.Like this, when assembling, the heat-exchange fluid inlet port 8B of the outlet 7C of first heat exchange module 7 and second heat exchange module 8 is aligned with each other, and the inlet port 7B of the heat-exchange fluid outlet 8C of this second heat exchange module 8 and next first heat exchange module 7 is also like this.

From Fig. 3,5,7 and 10 as can be seen, each processing module 1-3,6 comprises two through hole 1H-3H, 6H, when assembling, one of them is corresponding with heat-exchange fluid inlet port 7B, 8B, and another heat-exchange fluid outlet 7C, 8C with first and second

heat exchange modules

7,8 that described each processing module 1-3,6 is clipped in the middle is corresponding.Therefore, from Fig. 1,2 and 17 as can be seen, when when assembling, be used for holding and guide in first heat exchange module 7 and heat-exchange fluid passage 7A, the 8A of the heat-exchange fluid in second heat exchange module 8 are communicated with each other by the heat-exchange fluid interface channel that is formed by the through hole that is clipped in one of processing module 1-6 between described first heat exchange module 7 and second heat exchange module 8.

This heat-exchange fluid inlet port 7B of this heat exchange module that begins most 7 by the passage in the first connecting portion 12A that is provided at this first frame mounting 10 and is attached thereto, communicates with the first heat-exchange fluid holder (not shown).This heat-exchange fluid outlet 8C of this last heat exchange module 8 by the passage in the second connecting portion 12B that is provided at this second frame mounting 9 and is attached thereto, communicates with the second heat-exchange fluid holder (not shown).Like this, for example Wen heat-exchange fluid can the zigzag line, from this first holder, 7,8 groups of first and second heat exchange modules, second framework 9 and the second connecting portion 12B that communicate by this first connecting portion 12A, this first framework 10, via the heat-exchange fluid interface channel that provides in the processing module 1-6 that is clipped in the middle of described first and second

heat exchange modules

7,8, flow into second holder, thus, by the heat exchange of these module flat boards, heat all processing module 1-6 subsequently.

Provide adjustment module 1 as first processing module, it is more detailed demonstration in Fig. 3,4.Described adjustment module 1 comprises the first reacting fluid passage 1A, it communicates with the first reacting fluid inlet port 1C and the first reacting fluid outlet 1F, and the second reacting fluid passage 1B, it communicates with the second reacting fluid inlet port 1D and the second reacting fluid outlet 1E.By this first reacting

fluid inlet port

1C, 1A supplies first reacting fluid to this first reacting fluid passage.By this second reacting fluid inlet port 1D, supply second reacting fluid to this second reacting fluid passage.

Described adjustment module 1 comprises the first and second dull and stereotyped 1M, 1N (Fig. 4), and it is connected to each other by soldering etc.By etching, milling etc., in the contact-making surface of this first and/or second dull and stereotyped 1M, 1N, cut out sine-shaped reacting

fluid passage

1A, 1B.

When flowing to the described first reacting fluid outlet 1F through the described first reacting fluid passage 1A, the temperature of described first reacting fluid is regulated by two

heat exchange modules

7,8 that described adjustment module 1 is clipped in the middle.There, this heat-exchange fluid of the described

heat exchange module

7,8 of flowing through, rely on dull and stereotyped 1M, 1N by contacting described adjustment module heat exchange module dull and stereotyped 7N, 8M heat conduction supply or remove the heat of described first reacting fluid.

Mixing module 2 as second processing module is shown in Fig. 5,6.Although do not show in detail that described mixing module 2 comprises first and second flat boards, is similar to above-mentioned this adjustment module 1.In described mixing module, provide the reacting fluid passage 2A that comprises the 2G of mixing portion and the first maintaining part 2I.

The first reacting fluid inlet port 2C that communicates with described reacting fluid passage 2A is connected with this first reacting fluid outlet 1F of this adjustment module 1 by the joint outer part (not shown).The same second reacting fluid inlet port 2D that communicates with this reacting fluid passage 2A is connected with this second reacting fluid outlet 1E of this adjustment module 1 similarly.Like this, this first and second reacting fluid after described adjustment module 1, flows into the 2G of mixing portion of the passage 2A that is positioned at this mixing module 2 respectively, and wherein said two kinds of reacting fluids are mixed with each other.Can suitably select the geometry of the 2G of this mixing portion, shown in the enlarged drawing of Fig. 6, be used for mixing in the best way this reacting fluid.After the mixing, resulting processing fluid flows into the first maintaining part 2I of this reacting fluid passage 2A, and this passage 2A is substantially shaped as flat passage, and the processing fluid of laminar flow substantially is provided thus.

The shape that the geometry that it is emphasized that this processing module and heat exchange module 1-6,7,8 passage is not limited to shown in the figure and describes about preferred embodiment, but can be chosen as any suitable design.

The mixing that is positioned at this 2G of mixing portion and the first maintaining part 2I and resident during, two heat exchange modules, 7, the 8 control temperature that this chemical reaction can be clipped in the middle by this described mixing module 2.

This handles fluid, leaves this reacting fluid passage 2A by reacting fluid outlet 2E, enters the reacting fluid inlet port 3C that first shown in Fig. 7-9 keeps module 3.There, this reacting fluid outlet 2E is connected by (not shown)s such as pipe are outside with reacting fluid inlet port 3C.This keeps module 3, as other keeps module 4-6, mainly comprises the first dull and stereotyped 3M-6M that is connected with the second dull and stereotyped 3N-6N by soldering, welding etc.Between described two flat boards, provide passage 3A-6A to be used for during residence time, holding this processing fluid.There, sine-shaped basically flat passage is carved the contact-making surface that (carve) goes into this first and/or second flat board by quilts such as etching, millings.

When flowing through described reacting fluid passage 3A, this handles fluid by two heat exchange modules 7, the 8 control temperature adjacent with described maintenance module 3, as before to the description of this adjustment module 1 and mixing module 2.

After reacting fluid outlet 3D leaves this first maintenance module 3, this reacting fluid enters subsequently maintenance module 4-6 via the reacting fluid inlet port separately that is connected with the reacting fluid outlet of previous maintenance module, as before to the description of this reacting fluid inlet port 3C and this reacting fluid outlet 2E.Like this, before leaving this micro-reactor system through the outlet 6D of this last processing module, this reacting fluid all maintenance module 4-6 subsequently that can flow through.

This residence time in each keeps module 3-6 keeps volume by this, and promptly the passage 3A-6A of this maintaining part (width * highly) * length defines divided by flow velocity.Thus, different width, length and/or height by single passage is provided can obtain different residence times.So, combining by the different maintenance module that will have different channel geometries, this residence time almost can be selected arbitrarily.

From the contrast of Fig. 9 and 12 as can be seen, it shows this reacting fluid inlet port 3C, the 6C of this first and the

4th maintenance module

3 and 6 respectively, limit the flat width of channel of this reacting fluid passage 3A, 6A respectively, can make the width that is equal to or greater than this reacting fluid inlet port less than (Fig. 9), substantially.

As shown in Figure 1, 2, two pull bars 13 push away first and second frame mountings 10,9 towards each other, are pressing this heat exchange module that piles up 7,8 and processing module 1-6 to support each other thus.Pull bar 13 is placed on the circumference (circumference) of this micro-reactor system, and the centre of surface at this frame mounting 10,9 that contacts with this heat exchange module 7,8 provides cavity to see Figure 17), can obtain elevated pressures at the circumference of this micro-reactor system.Therefore, this heat-exchange fluid inlet port 7B, 8B and heat-exchange fluid outlet 7C, the 8C of this heat exchange module 7,8, it is provided at the circumference of this micro-reactor system equally, is pressed against the heat-exchange fluid interface channel 1H-6H that is positioned at this processing module 1-6 with elevated pressures.If this heat exchange module 7,8 is made by toughness material such as aluminium, copper or its alloy, the perimeter edge of this inlet port and outlet is distortion a little under pressure, provides good sealing to the surface that is clipped in this processing module 1-6 therebetween thus.Like this, heat-exchange fluid outlet 7C, the 8C of two heat exchange modules 7,8 subsequently and heat-exchange fluid inlet port 7B, 8B via this heat-exchange fluid interface channel 1H-6H in the processing module that is provided at this centre not the leakage current body communicate.

In addition, can provide around the sealing ring (sealing ring) of this heat-exchange fluid inlet port 7B, 8B and heat-exchange fluid outlet 7C, 8C.There, for example in this first and second dull and stereotyped 7M, 7N, 8M, 8N, can provide cannelure respectively, hold the sealing ring (not shown) within it.Such sealing ring can be made by rubber, silicon or special teflon (preferably) etc.

Understandable as description from the front, according to micro-reactor system of the present invention owing to its modular construction provides high flexibility, and the different maintenance module combination that permission will have different hybrid channel geometries, optional residence time is provided thus, especially Type B is reacted.Each described processing module 1-6 is by two adjacent heat exchange modules, 7,8 control temperature.Because heat is only transmitted by the heat conduction through this flat board 1M-8M, the 1N-8N of this

heat exchange module

7,8 and processing module 1-6 and is realized that sealing etc. are dispensable.And, advantageously, can optimize this processing module 1-6 about this reactant that is contained in wherein, for example anticorrosive and/or pressure, and simultaneously, can optimize this heat exchange module that does not contact 7,8 about heat transmission and/or sealing characteristics with these reactants.

In the above-described embodiments,

heat exchange module

7,8 and processing module 1-6 alternately pile up each other, and this heat-exchange fluid is from first holder, through the first connecting portion 12A, through all

heat exchange modules

7,8, flow into second holder that is connected to the second connecting portion 12B with the zigzag line.Thus, the connector of all heat-exchange fluids of this

heat exchange module

7,8 is provided at inside, without any extra connector.Advantageously, can use standardized processing module and heat exchange module, this make be easy to, modular mode assembles the different microreactors with different residence times etc. and becomes possibility.

In the above-described embodiments, adjustment module 1, mixing module 2 and four keep module 3-6 to combine in proper order with this.Yet any combination of these modules is possible.For example can provide more adjustment modules to be increased in the passage that wherein heats or cool off these reactants.Multistep is reacted suddenly, more polyhybird module can be provided.Can provide different maintenance module to realize required residence time.

In test sample, with as 100ml/ minute given flow velocity, the about 1844mm of passage length, channel height 10mm and the channel width 0.5-2mm of processing module, the residence time 6-22 second of having realized each module.Like this, can realize total residence time up to 30 minutes.

Unexpectedly, verified continuous processing module 1-6 continuous connects the not temperature control of this microreactor of appreciable impact.Because each processing module 1-6, especially each keeps module 3-6, can be controlled temperature (heating, cooling or heat buffering) from both sides very effectively, and reaction can be in this microreactor, carry out in wide temperature range.Example among the embodiment as described, preferably, a

heat exchange module

7,8 transmits heat from continuous processing module, perhaps heat is passed to continuous processing module 1-6 (except begin most with last heat exchange module).

These reacting fluid passages in this processing module 1-6 form micro-structural by etching, milling or the like.Because this

heat exchange module

7,8 is made respectively, they can be fabricated to and not have this micro-structural, reduce cost like this.In addition, because described

heat exchange module

7,8 does not contact with these reactants, they do not need corrosion-resistant or high processing pressure, therefore allow to use material best concerning heat is transmitted.Especially following material can be used for heat exchange module.

Aluminium alloy AlMgSi1 (=EN AW-6082 or EN6082):

EN?AW-6082?EN?AW-AlSi1MgMn?AlMgSi1?DIN3.2315

EN?AW-6061 EN?AW-AlMg1SiCu AlMg1SiCu DIN?3.3211

EN?AW-6005A EN?AW-AlSiMg(A) AlMgSiO，7 DIN?3.3210

EN?AW-6012 EN?AW-AlMgSiPb AlMgSiPb DIN?3.0615

EN?AW-6060 EN?AW-AlMgSi AlMgSiO，5 DIN?3.3206

On the contrary, this processing module 1-6 can be made by following material, for example:

DIN?1.4571 AlSl?316?Ti ×10 CrNiMoTi?18?10

DIN 2.4602 NiCr21Mo14W nickel-base alloy C-22

DIN 2.4610 NiMo16Cr16Ti nickel-base alloy C-4

DIN 2.4617 NiMo28 nickel-base alloy B-2

DIN 2.4819 NiMo16Cr15W nickel-base alloy C-276

DIN 2.4816 NiCr15Fe inconel 600

DIN 2.4856 NiCr21Mo9Nb inconel 625

DIN 2.4858 NiCr21Mo inconel 825

Claims

1. micro-reactor system comprises following storehouse:

At least n processing module (1-6), wherein n is equal to or greater than 1 integer, each processing module (1-6) is made by first material of rigidity, and comprise at least one reacting fluid passage (1A, 1B, 2A, 3A, 6A), this reacting fluid passage passes described processing module (1-6), and between at least one reacting fluid inlet port (1C, 1D, 2C, 2D, 3C, 6C) with at least one reacting fluid outlet (1E, 1F, 2E, 3D, 6D), be used to hold and guide reacting fluid, wherein, under the situation that at least two processing modules (1-6) arranged, described at least two processing modules (1-6) series connection;

And n+1 heat exchange module (7 at least, 8), each described heat exchange module (7,8) make by second material of the flexible that is different from described first material, and comprise at least one heat-exchange fluid passage (7A, 8A), this heat-exchange fluid passage passes described heat exchange module (7,8) inside, and between at least one heat-exchange fluid inlet port (7B, 8B) with at least one heat-exchange fluid outlet (7C, 8C), be used to hold and guide heat-exchange fluid, the wherein said heat exchange module of n+1 at least (7,8) series connection

2. according to the micro-reactor system of claim 1, wherein

Anticorrosive and the pressure of described first material, and preferably be selected from the group of forming by stainless steel, nickel-base alloy, tungsten, tantalum, titanium, pottery, graphite, and/or the appropriate combination of one or more described first materials; And

Second material is heat conduction, and preferably is selected from the group of being made up of aluminium, aluminium alloy, copper, copper alloy, silver and silver alloy, and/or the combination of one or more described second materials.

3. according to the micro-reactor system of claim 1 or 2, the wherein said processing module of n at least (1-6) comprises:

Mixing module (2), its at least one reacting fluid passage (2A) comprises the mixing portion (2G) that is used to hold and mix at least two kinds of reacting fluids;

Alternatively, thermal conditioning module (1) is located at described mixing module (2) upstream, is used for entering described mixing module (2) before, regulates the temperature of described at least two kinds of reacting fluids; And

Alternatively, one or more maintenance modules (3-6) are located at the downstream of this mixing module (2), are used to hold this reacting fluid mixture.

4. according to each micro-reactor system in the claim 1 to 3, wherein

Described at least one reacting fluid passage (1A, 1B, 2A, 3A, 6A) is flat passage, comprise crooked and/or straight part, each reacting fluid can be flowed along crooked route, described flat passage preferably has the wide/height ratio in 1: 4 to 1: 50 scope, more preferably in 1: 4 to 1: 30 scope, even more preferably in 1: 5 to 1: 25 scope.

5. according to each microreactor in the claim 1 to 4, the wherein said processing module of n at least (1-6) comprises the processing modules of at least two outside series connection.

6. according to each micro-reactor system in the claim 1 to 5, the wherein said heat exchange module of n+1 at least (7,8) comprises:

First heat exchange module (7), its at least one heat-exchange fluid inlet port (7B) communicates with the first heat-exchange fluid holder, with and heat-exchange fluid outlet (7C) communicate with subsequently heat exchange module (8);

Second heat exchange module (8), its at least one heat-exchange fluid outlet (8C) communicates with the second heat-exchange fluid holder, with and heat-exchange fluid inlet port (8B) communicate with the heat exchange module (7) of front; And alternatively

The heat exchange module that at least one is other is located between described first heat exchange module (7) and second heat exchange module (8), and connects with this first heat exchange module (7) and second heat exchange module (8);

Wherein the series connection of two continuous heat exchange modules (7,8) realizes in inside by at least one heat-exchange fluid interface channel (1H, 2H, 3H, 6H), and this heat-exchange fluid passage is by this each of individual processing module (1-6) that is clipped in the middle by two continuous heat exchange modules (7,8) of n at least.

7. according to each micro-reactor system in the claim 1 to 6, wherein said processing module of n at least (1-6) and/or the described heat exchange module of n+1 at least (7,8) each comprises preferably by soldering, brazing, welding, bonding grade makes permanent each other first flat board (1M-8M) and second flat board (1N-8N) that connects, wherein said reacting fluid passage, the heat-exchange fluid passage, reacting fluid inlet port and reacting fluid outlet and/or heat-exchange fluid inlet port and heat-exchange fluid outlet (1A, 1B, 1C-1F, 2A, 2C-2E, 2G, 3A, 3C, 3D, 6A, 6C, 6D, 7A, 8A) each is positioned between described first flat board (1M-8M) and second flat board (1M-8M).

8. according to the micro-reactor system of claim 7, each of wherein said reacting fluid passage, heat-exchange fluid passage, reacting fluid inlet port and reacting fluid outlet and/or heat-exchange fluid inlet port and heat-exchange fluid outlet (1A, 1B, 1C-1F, 2A, 2C-2E, 2G, 3A, 3C, 3D, 6A, 6C, 6D, 7A, 8A) is to obtain by the inner surface of at least one in ablate described first flat board (1M-8M) and second flat board (1N-8N).

9. according to the micro-reactor system of claim 7, wherein structurized in the middle of dull and stereotyped (70,80) be sandwiched between described first flat board (7M, 8M) of the described heat exchange module of n+1 at least (7,8) and second flat board (7N, 8N) so that described heat-exchange fluid passage (7A, 8A) to be provided.

10. according to each micro-reactor system in the claim 1 to 9, further comprise:

First frame mounting (10); And

Second frame mounting (9),

Wherein said processing module of n at least (1-6) and the described heat exchange module of n+1 at least (7,8) are pressed each other by described first and second frame mountings (9,10).