CN101375913B - Pharmaceutical combination for preventing birth-defect and improving memory - Google Patents
Pharmaceutical combination for preventing birth-defect and improving memory Download PDFInfo
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- CN101375913B CN101375913B CN2008102238413A CN200810223841A CN101375913B CN 101375913 B CN101375913 B CN 101375913B CN 2008102238413 A CN2008102238413 A CN 2008102238413A CN 200810223841 A CN200810223841 A CN 200810223841A CN 101375913 B CN101375913 B CN 101375913B
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Abstract
A medicament combination used for preventing birth defects and improving memory comprises Atractylodes rhizome, cornel, vitamin A, beta-carotene, vitamin B complex, vitamin C, vitamin D, as well as major elements of calcium and magnesium and trace elements of zinc, selenium, iron, chromium and molybdenum. The medicament combination is mainly suitable for pregestational women, pregnant women and nursing mothers, and is very effective in preventing the birth defects and improving the memory. Meanwhile, the medication combination has healthcare and nutritional efficacies, and causes no side effect even after long-term administration.
Description
Technical field: the present invention relates to the Medicines and Health Product technical field; In particular for prevention birth defect and the pharmaceutical composition that improves memory.
Background technology: birth defect is meant that fetus is in parent and in the organ formative process of birth back; Disorderly by the embryo due to the various factors effect and paedomorphosis, comprise that morphosis is unusual, 4 types of physiological metabolism obstacle, congenital mental retardation and intrauterine growth retardations etc.; Various countries' birth defect incidence rate is up to about 5% of the birth sum, and is great to the population quality influence, causes white elephant for family, society, become the common great public health problem of paying close attention in the present whole world.
The pathogenic factors of birth defect is very complicated, and inherited genetic factors is arranged, and environmental factors also has other multiple uncertain factor.Environmental factors comprises biological factor, physical factor, chemical factor; The embryo receives the injury of environment harmful factor and other multiple uncertain factor, the birth defect sickness rate is increased, and eliminate these harmful factors, and the birth defect sickness rate is lowered.
Pharmaceutical composition of the present invention is a policy of following prenatal and postnatal care; Through eliminating the birth defect factor that causes to the embryo, the generation of prevention birth defect reaches the purpose that lowers the birth defect sickness rate; Simultaneously user there is the memory impairments of improvement, favourable mothers and sons two generations's health; Said composition comprises the Rhizoma Atractylodis Macrocephalae, Fructus Corni, vitamin A, beta-carotene, compound vitamin B, vitamin C, vitamin D, vitamin E and macroelement calcium, magnesium and trace element zinc, selenium, ferrum, chromium, molybdenum.
The Rhizoma Atractylodis Macrocephalae is a kind ofly can invigorating the spleen and benefiting QI be arranged as the QI invigorating class natural Chinese medicine of health food, the dampness diuretic, the hidroschesis consolidating superficial resistance and in antiabortive effect; Ancient Chinese medicine is classified the Rhizoma Atractylodis Macrocephalae as on Chinese medicine article, antiabortive monarch drug, the panacea of fetus nourishing; The modern clinical cirrhotic ascites that are used for more, diarrhoea, Mo Niai syndrome, edema spontaneous perspiration, frequent fetal movement etc.; Modern pharmacological research confirms: 1, Rhizoma Atractylodis Macrocephalae Wheat Protein; Can alleviate lipid peroxidation; Reduce the content of peroxide, avoid the destruction of harmful substance pair cell 26S Proteasome Structure and Function, and SOD activity improving trend is arranged; Enhancing body is to the ability of free radical scavenging, thus the damage of minimizing radical pair body; 2, the Rhizoma Atractylodis Macrocephalae has delaying senility function, and Rhizoma Atractylodis Macrocephalae decoct can improve the erythrocytic superoxide dismutase of aged mouse (SOD) activity, suppresses the brain activity of monoamine oxidase simultaneously, can also suppress erythrocytic autoxidation haemolysis, directly removes free radical, shows anti-aging effects; 3, the Rhizoma Atractylodis Macrocephalae has the enhance immunity effect, and oral lymhocyte transformation rate and the serum IgG content of making of Rhizoma Atractylodis Macrocephalae decoct significantly rises, and shows that the Rhizoma Atractylodis Macrocephalae has immunostimulation, and can strengthen the vigor of macrophage, strengthens the phagocytic function of reticuloendothelial system; 4, anticancer tumor effect, Rhizoma Atractylodis Macrocephalae volatile oil has inhibitory action to murine sarcoma S180, and external have direct killing action to the ehrlich ascites tumor cell; And external the Eca109 esophageal cancer cell is presented inhibition, can make cell detachment, karyopycnosis; Chromatin concentrates, and cell does not divide or seldom division; 5, the Rhizoma Atractylodis Macrocephalae also has the blood lipid-reducing blood sugar-decreasing effect, antibacterial action, and blood coagulation resisting function promotes the brood weight increase, physical potentiation raises to can be made leukocyte count by the leukopenia that causes after chemotherapy or the radiotherapy tumor; The compatibility Rhizoma Atractylodis Macrocephalae is to promote the absorption of medicine active ingredient in prescription for traditional Chinese medical science custom, and particularly compatibility gold, stone class medicine are to promote the absorption and the utilization of mineral.
Fructus Corni is a kind ofly can liver and kidney tonifying be arranged as the astringents natural Chinese medicine of health food, restrains astringent or styptic treatment for spontaneous sweating effect; Clinically be used to treat deficiency of both the liver and kidney, dizzy, sexual impotence, the spermatorrhea enuresis, sweating due to debility, diseases such as metrostaxis; Modern pharmacological research confirms that Fructus Corni has: 1, raise immunity; 2, activity of fighting against senium; 3, antioxidation; 4, blood sugar lowering, effect for reducing blood fat; 5, anti-hemorrhagic shock effect; 6, anti-stress, antifatigue effect; 7, antiplatelet aggregation, anti-thrombosis function; 8, the effect of memory reinforcing; 9, also have antiinflammatory in addition, antibiotic, protect the liver, can kill effect such as ascites cells external.
Vitamin A is also claimed retinol, and the effect that improves vision, prevents nyctalopia is arranged, and the anemia of pregnant woman of enhancing Abwehrkraft des Koepers function is arranged; Can promote mucopolysaccharide synthetic; Influence renewal, the growth of osseous tissue, long bone is grown to both-end, if VAD is prone to premature labor or fetal congenital deformity; Beta-carotene can change vitamin A under the effect of enzyme in vivo, the effect of performance vitamin A.
Vitamin B group is participated in body internal protein, fat and sugar metabolism, makes the excitement of brain cell and inhibition be in poised state, and it comprises vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid etc., collaborative in vivo performance physiological action.Vitamin B
1Have the effect of keeping the nervous system normal function, phenomenon such as it is incomplete to occur carbohydrate metabolism during shortage, and heat energy is under-supply, thus cause hypomnesis, influence the normal function of brain, if vitamin B
1Abundance can effectively form the necessary energy of brain cell activity, but improving memory, concentration power and learning capacity, vitamin B in addition
1Suppress cholinesterase in addition, improve the function of cholinergic nerve; Vitamin B
2Having another name called riboflavin, is the ingredient of many important coenzyme in the body, and it participates in intravital substance metabolism, promotes fetus and baby's growth promoter to play an important role vitamin B to the activity that earns a bare living
2Be to keep skin and the requisite vitamin of eye health, anemia of pregnant woman's vitamin B
2Lack or can not cause or inspire pregnant early pregnancy completely and vomit, second trimester angular cheilitis, glossitis, cheilitis and premature infant's incidence rate increase; Nicotiamide is claimed niacin amide or vitamin PP again, and its physiological function is to participate in the body intracellular metabolic, keeps normal neurological function, and pellagra can take place during shortage in synthesizing of assurance gonadal hormone etc., mainly shows as dermatitis, diarrhoea, dull-witted three big symptoms; Pantothenic acid extensively exists in each organism, participates in metabolic activity widely, and known have 70 plurality of enzymes in all kinds of biochemical reaction of catalysis body, all to need pantothenic acid to participate in, otherwise just can Metabolic disorder; Biotin also is a kind of vitamin B group, coordinates to participate in the metabolism of human body matter and energy with other vitamin B group, and it is synthetic with nucleic acid, and the compositive relation of gonadal hormone is close, and it also has control poliosis, bareheaded effect; Vitamin B
6Most important to the maincenter neurodevelopment, if shortage can make the nervus centralis hypoevolutism, intelligence descends, and it has the assistance vitamin B
1Effect, be the vitamin that can improve concentration power and stimulate desire learn; Vitamin B
12Participate in nucleic acid in vivo, choline, amino acid whose metabolism that is synthetic and fatty and sugar; To hemopoietic function of bone marrow, the gastrointestinal epithelial cells function, liver function and nervous system myelin functional integrity have certain effect; It is the necessary vitamin of intelligence of bringing into normal play; Not only cause dysnoesia if lack, also nutritional anemia can occur, influence is to blood supply in the brain; Folic acid is participated in the synthetic of aminoacid and nucleic acid, and and vitamin B
12The common generation that promotes cell is with ripe, and normal cell can not carry out mitosis during shortage, the neurological symptom can occur, as: the loss of memory, depression and dementia etc.; Human body can be at vitamin B in addition
12Under the effect of folic acid as cofactors, by serine of taking in and the synthetic choline of methionine, choline is the key component of acetylcholine, and acetylcholine is a neurotransmitter important in the human body; Folic acid, vitamin B are arranged again
6And vitamin B
12Can work in coordination with and remove the intravital homotype cysteine of people, the homotype cysteine is a kind of neurotoxin, can cause the self murder of brain; There are some researches show that homocysteine is a kind of potential teratogen of independently growing, and is related closely with congenital heart disease and NTD; Homocysteine also can cause miscarriage, premature labor in addition, clinical disastrous effect such as preeclampsia.
Vitamin C is claimed ascorbic acid again, and vitamin C and collagen in close relations not only has the vessel softening effect; The effect that purifies the blood in addition; Prevent arteriosclerosis, can also promote the absorption of human body, for hemopoietic provides essential raw material ferrum in the food; Simultaneously, vitamin C regain one's strength, aspect effect such as allaying tiredness, keeping tensions down emotion is obvious; Pregnancy duration, subcutaneous hemorrhage can appear in anemia of pregnant woman's hypovitaminosis C or deficiency, swelling and aching of gum, symptom such as bleed, fester, the long-term lacking vitamin C is prone to have virus flu, and increases the danger of fetus teratogenesis, and famine can cause miscarriage.
Vitamin D is the sterols derivant, and the subcutaneous dehydrocholesterol of human body produces vitamin D through ultraviolet radiation
3, ergosterol produces vitamin D behind ultraviolet radiation
2, the two originates different, and function is consistent, and the importance of vitamin D is to regulate the metabolism of calcium and phosphorus in human nutrition; Vitamin D promotes calcium in little intestinal absorption; The then a large amount of calcium of the D that is deficient in vitamin are discharged by feces, thereby cause the human body calcium deficiency, and rickets can take place the child; Become the calcium phosphorus of storing in the human body to exhaust and can cause osteomalacia, modal osteomalacia crowd is anemia of pregnant woman, wet nurse and old people.
Vitamin E is all general designations with the bioactive chromone derivative of alpha-tocopherol; Wherein the activity of alpha-tocopherol is the highest; Have the effect of eliminating free radical, slow down aging, prevention maxicell property hemolytic anemia, medically often adopting vitamin E treatment male and female infertility and threatened abortion; Vitamin E deficiency or anemia of pregnant woman's reproductive system is suffered damage, irreversible variation takes place in germinal epithelium, in addition, phenomenons such as maxicell property hemolytic anemia and red blood cell life span shortening can take place also.
Calcium is the macroelement that body weight for humans is wanted; Main two aspects that play a part; The one, constitute sclerous tissueses such as bone tooth; The 2nd, constitute the material of specific function with protein bound or with the form of calcium ion, form in so-called miscible calcium pool and the bone tooth calcium and keep dynamic equilibrium, all cells all need its normal function of calcium competence exertion in the body; Anemia of pregnant woman and wet nurse's calcium deficiency can influence the growth of its body constitution and fetus or infant, and calcium deficiency can cause that also endocrine dysfunction and cell cycle regulation are malfunctioning, and anemia of pregnant woman and wet nurse are owing to physiological characteristics, the Deficiency of Intake of ubiquity calcium.
Magnesium topmost function in human body is the generation of containment free radical, and free radical is short old and feeble factor, also is the factor that mainly causes birth defect; Another of magnesium function is to bring into play the effect of protection skeleton with calcium and vitamin D, and osteoporosis takes place magnesium deficiency easily, fractures easily; Magnesium is protected heart and the function etc. of preventing and treating diabetes in addition in addition.
Trace element zinc is merged in the biomacromolecule ligand---in protein, nucleic acid, the film (being mainly memebrane protein); Generate stable metallic biomacromolecule complex---metalloprotein, metalloproteinase nucleic acid complex etc.; At present; Known these materials are participated in the synthetic and degradation process of carbohydrate, lipid, protein and nucleic acid, and the existence of zinc enzyme is all arranged in six big fermentoids; Zinc also is the essential element of enhance immunity vigor; Zinc can promote that proinsulin is converted into insulin through activating protaminase, and zinc deficiency makes insulin be obstructed in the activity of peripheral tissues, and it is unusual to cause glucose tolerance curve; Anemia of pregnant woman's zinc deficiency can influence the growth promoter of fetus to some extent, so that causes all deformities of fetus; Zinc deficiency can cause brain development bad, incomplete development of mind.
Trace element-selenium has obvious reduction serum total cholesterol, triglyceride and MDA, improves high density lipoprotein, the metabolic effect of superabundant fats in the acceleration bodies; Selenium also has the strong anti-oxidation function, and the protection embryo does not receive the injury of superoxides, prevention of cardiac; Anticancer through enhance immunity recognition system removing cancerous cell; Remove and the drainage heavy metal ion, hydrargyrum, methyl mercury, cadmium, lead etc. are had Detoxication, and heavy metal pollution is mainly to cause the birth defect factor; Scarce selenium can make the human insulin secretion reduce, impaired glucose tolerance, and oxidation resistance descends and quickens human senility and intelligence decline.
The major physiological function of trace elements iron is as hemoglobin, MG Myoglobin HMYO, and the ingredient of cytochrome etc. is participated in transporting and the Tissue respiration process of the interior oxygen of body, in the conveying of oxygen and electronics, plays central role; Contain ferrum in the catalatic structure, and hydrogen peroxide relies on catalatic degraded, hydrogen peroxide is a free radical the most dangerous in the human body; Iron deficiency is common in infant, anemia of pregnant woman and wet nurse; Cause iron deficiency anemia, its cardinal symptom is to have a delicate constitution, and memory weakens; Ability to work descends; Iron deficiency also can exert an influence to other system of human body, like the nervous system iron deficiency, can affect the nerves conduction and makes the child occur that intelligence reduces and behavior disorder.
Chromium is a kind of essential trace element, has only trivalent chromium can be used for the supplement of chromium, and it can strengthen and promote the physiological action of insulin, and it can harden by prevention of arterial, and raise immunity promotes growth promoter; Scarce chromium can cause growth promoter to be stagnated, and quickens old and feeble.
Molybdenum is one of micro elements needed by human, and it is the formation element of plurality of enzymes, participates in the utilization of ferrum; Promote erythrocytic growth and maturation, can prevent anemia, and can help the metabolism of carbohydrate and fat; It participates in removing the murder by poisoning of poisonous aldehydes in the human body; Eliminate human free radical, have anticancer, defying age, enhancing immunity and anticariogenic function; Scarce molybdenum can bring out cardiovascular disease, cancer and dental caries.
Application contains the Rhizoma Atractylodis Macrocephalae, Fructus Corni, vitamin A, beta-carotene, vitamin B
1, vitamin B
2, vitamin B
6, nicotiamide, pantothenic acid, biotin, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E and macroelement calcium, magnesium and trace element zinc, selenium, ferrum, chromium, molybdenum be known as the compositions of active component, but with the Rhizoma Atractylodis Macrocephalae, Fructus Corni, vitamin A, beta-carotene, vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E and macroelement calcium, magnesium and trace element zinc, selenium, ferrum, chromium, the molybdenum compatibility pharmaceutical composition that is used to prevent birth defect and improve memory report as yet.
Current medicine that is used to improve memory or health food kind have multiple, but aim at pregnant before the medicine or the health food that are used to improve memory of women, anemia of pregnant woman, wet nurse's development do not see as yet; Do not see the medicine label that is used to prevent birth defect as yet, rarely seen report that folic acid prevention NTD is arranged, but its target spot is few, and the link shortcoming needs perfect; And will prevent birth defect not see as yet with improving the effect of remembering and being used for same medicine person.
Summary of the invention: in order to overcome existing prevention birth defect and/or to improve the shortcoming and defect of remembering medicine; The purpose of this invention is to provide a kind of compositions; Said composition is passed through absorption and the utilization that the Rhizoma Atractylodis Macrocephalae promotes vitamin, mineral, and works in coordination with increase vitamin A, beta-carotene, vitamin B with Fructus Corni
1, vitamin B
2, vitamin B
6, nicotiamide, pantothenic acid, biotin, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E and macroelement calcium, magnesium and trace element zinc, selenium, ferrum, chromium, molybdenum improve the effect of memory and prevention birth defect, simultaneously through macroelement calcium, magnesium and trace element zinc, selenium, ferrum, chromium, molybdenum and vitamin A, beta-carotene, vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E, replenish and strengthen the effect of the antiabortive and Rhizoma Atractylodis Macrocephalae of Rhizoma Atractylodis Macrocephalae fetus nourishing and Fructus Corni antioxidation, defying age, enhance immunity, blood sugar lowering, blood fat reducing, memory reinforcing; Even chronic administration also has no side effect; Because the result of broad research, the inventor has found the Rhizoma Atractylodis Macrocephalae, Fructus Corni and vitamin A, beta-carotene, vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin C, vitamin D vitamin E and macroelement calcium, magnesium and trace element zinc, selenium, ferrum, chromium, molybdenic novel combination, this novel combination for the prevention birth defect with improve memory synergy arranged; And single with the Rhizoma Atractylodis Macrocephalae, Fructus Corni and vitamin A, beta-carotene, compound vitamin B, vitamin C, vitamin D, vitamin E and macroelement calcium, magnesium and trace element zinc, selenium, ferrum, chromium, molybdenum, its effect is all not as good as this compositions; And the effective ingredient of each component has the addition complementary action to the health care tonification of human body, as the Rhizoma Atractylodis Macrocephalae of the used dosage of this compositions have that fetus nourishing is antiabortive, the effect of defying age, enhance immunity, physical strength reinforcing; Fructus Corni has liver and kidney tonifying, the astringent or styptic treatment for spontaneous sweating effect of convergence; Trace element zinc is the necessary material of zinc enzyme in the interior six big fermentoids of human body, also is the essential element of enhance immunity vigor; But the metabolism of superabundant fats has the strong anti-oxidation function, prevention of cardiac function, anti-cancer function etc. in the trace element-selenium acceleration bodies; Trace elements iron is participated in transporting and the Tissue respiration process of the interior oxygen of body, is the only element that prevents iron deficiency anemia; Trace element chromium has prevention of arterial sclerosis, enhance immunity, antidotal function; Trace element molybdenum has anticancer, defying age, enhance immunity and anticariogenic function; And for example vitamin A has the raising vision, prevents the effect of nyctalopia; Vitamin B
1Can prevent and treat vitamin B1 deficiency, keep the normal activity of nerve, digestion, muscle, blood circulation; Vitamin B
2Be to keep skin and the requisite vitamin of eye health; Pellagra can take place in nicotinamide deficiency; The pantothenic acid shortage can cause Metabolic disorder; Biotin can be prevented and treated poliosis, alopecia; Vitamin B
6Can eliminate intraepithelial neoplasia cells, raise immunity, protection blood vessel; Vitamin B
12Be used for various megaloblastic anemias and neural disease; Folic acid is protected heart and antitumaous effect in addition; Vitamin C has vessel softening, purifies the blood, prevents arteriosclerotic effect; Vitamin E has removing free radical, function in delaying senility; Macroelement calcium, magnesium and vitamin D are brought into play the effect of protection skeleton jointly; There is not incompatibility in this compositions, have no side effect, and cost is low, thereby constitutes the present invention.
The invention provides the pharmaceutical composition that is used to prevent birth defect and improvement memory, it comprises the Rhizoma Atractylodis Macrocephalae, Fructus Corni and vitamin A, beta-carotene, vitamin B as active component
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E and macroelement calcium, magnesium and trace element zinc, selenium, ferrum, chromium, molybdenum.
The Rhizoma Atractylodis Macrocephalae is the Compositae herbaceos perennial Rhizoma Atractylodis Macrocephalae (Atractylodes macrocephala koidz) rhizome.Main product in Zhejiang, ground such as Hubei, Hunan.Gather winter, dries or dry, and life usefulness or parching with earth, parched with bran are used.The used Rhizoma Atractylodis Macrocephalae of the present invention can use its extract as raw material.
Fructus Corni is that the ripe dry sarcocarp of Cornaceae machaka or arbor Fructus Corni Cornus officinalis Sieb.et Zucc. supplies usefulness, ground such as main product Henan, Shaanxi, Zhejiang, Anhui, Shanxi; The used Fructus Corni of the present invention can use its extract as raw material.
Be used for vitamin B of the present invention
1(VitaminB
1), vitamin B
2(VitaminB
2), nicotiamide (Nicotinamide), pantothenic acid (Pantothenic Acid), biotin (Vitamin H), vitamin B
6(VitaminB
6), vitamin B
12(VitaminB
12), folic acid (Folic Acid), vitamin C (VitaminC), all are water soluble vitamins, do not accumulate in vivo; Vitamin A (Vitamin A), vitamin D (VitaminD), vitamin E (Vitamin E) are fatsoluble vitamiies, and beta-carotene (BetaCarotene) is the precursor substance of vitamin A, and be useful and harmless by the used dosage of the present invention; Zinc (Zn), selenium (Se), ferrum (Fe), chromium (Cr), molybdenum (Mo) are micro elements needed by human, and calcium (Ca), magnesium (Mg) are the macroelements of needed by human; Macroelement calcium among the present invention can be selected calcium gluconate, calcium lactate, calcium acetate, calcium caseinate, calcium chloride, calcium citrate, calcium malate, calcium cirate malate, calcium hydrogen phosphate, dalcium biphosphate, calcium phosphate, calcium sulfate, calcium ascorbate, calcium glycerophosphate, calcium carbonate etc. for use; Macroelement magnesium can be selected magnesium chloride, magnesium gluconate, magnesium lactate, magnesium citrate, magnesium hydrogen phosphate, magnesium phosphate, magnesium glycerophosphate, magnesium carbonate etc. for use; Trace element zinc can be selected zinc citrate, zinc acetate, zinc carbonate, zinc oxide, zinc chloride, zinc lactate, zinc sulfate, zinc gluconate, single zinc methionine etc. for use; Trace element-selenium can be selected Selenomethionine, methoxybenzyl cyanic acid selenium, the two cyanic acid selenium of phenylene, sodium selenite, selenocarrageenan, selenocysteine, selenizing methionine, sodium selenate etc. for use; Trace elements iron can be selected Ferrous gluconate, ferrous lactate, ferric ammonium citrate, iron chloride, ferric citrate, ferrous carbonate, ferrous citrate, ferrous fumarate, heme iron, ferric phrophosphate, protohemin, ferrous succinate, ferrous sulfate etc. for use; Trace element chromium can be selected chromium trichloride, nicotinic acid chromium, chromium picolinate, chromium yeast etc. for use; Trace element molybdenum can be selected ammonium molybdate, sodium molybdate etc. for use, and professional production factory and supplier are all arranged.
Compositions of the present invention mainly is applicable to women in pregnant early stage, anemia of pregnant woman and wet nurse; Receive the influence of factors such as geology, food chain, dietetic life custom and Time of Administration length, the effective dose that the crowd that benefits from benefits from this compositions each component has certain difference; By the present invention, the effective dose of Rhizoma Atractylodis Macrocephalae extract is counted 300-15000mg/ days with whole crude drug, and the effective dose of Fructus Corni extract is counted 300-10000mg/ days with whole crude drug, vitamin B
1Effective dose be 0.5-20mg/ days, vitamin B
2Effective dose be 0.5-20mg/ days, the effective dose of nicotiamide is 5-50mg/ days, the effective dose of pantothenic acid is 2-20mg/ days, the effective dose of biotin is 0.01-0.1mg/ days, vitamin B
6Effective dose be 0.5-10mg/ days, vitamin B
12Effective dose be 0.001-0.025mg/ days, the effective dose of folic acid is 0.1-1mg/ days, ascorbic effective dose is 30-500mg/ days, the effective dose of vitamin A and/or beta-carotene (in retinol equivalent) is 250-800 μ gRE/ days; The effective dose of vitamin D is 0.0015-0.01mg/ days; The effective dose of vitamin E (in the alpha-tocopherol equivalent) is 5-150mg α-TE/ days; The effective dose of macroelement calcium is counted 250-1000mg/ days with element calcium, and the effective dose of magnesium is counted 100-300mg/ days with element magnesium, and the effective dose of trace element zinc is counted 5-20mg/ days with element zinc; Selenic effective dose is counted 0.015-0.1mg/ days with elemental selenium; The effective dose of ferrum is counted 5-20mg/ days with elemental iron, and the effective dose of chromium is counted 0.015-0.15mg/ days with elemental chromium, and molybdenic effective dose is counted 0.02-0.06mg/ days with molybdenum.
Compositions of the present invention can or directly be taken by following pharmaceutical dosage forms dispenser; For example; Oral formulations (like granule, powder, capsule, ball, sheet, dry syrup, liquid formulation); Or food such as food (like cookies); Mix and prepare with other known additives; This type additive is for example: carrier, disintegrating agent, slow releasing agent, excipient, filler, covering, binding agent, lubricant, antioxidant, coating agent, coloring agent, correctives, sweeting agent, sucrose succedaneum, nutrition enhancer, flavouring agent, surfactant, plasticizer, PH regulator, freshener, suspending agent, defoamer, antiseptic, thickening agent, solubilisation aids etc. prepare or they are added food as functional component or additive by usual way.
By the present invention, the Rhizoma Atractylodis Macrocephalae, Fructus Corni, vitamin A, beta-carotene, vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E and macroelement calcium, magnesium and trace element zinc, selenium, ferrum, chromium, molybdenum each component can distinguish preparation, can the preparation of each component be mixed the back when using and use or do not mix simultaneously and use.
Advantage of the present invention is that this compositions is eliminated the multiple factor that causes birth defect and cause hypomnesis from too many levels, multisystem, many target spots, and the effect of collaborative performance effect is arranged between the each component, to preventing birth defect and improving memory significant effect is arranged; Sufficient raw; Cost is low, and each component has no side effect in the compositions, no incompatibility; Except that prevention birth defect and improvement are remembered, human body still there is the health care benefiting action.
Subordinate list 1 is this compositions and the Rhizoma Atractylodis Macrocephalae and Fructus Corni component and the young rat/mouse labyrinth test effect comparison of vitamin added elements component.
Subordinate list 2 is this compositions and the Rhizoma Atractylodis Macrocephalae and Fructus Corni component and the comparison of vitamin added elements component Aged Mice maze test effect.
Relatively tabulate below with reference to embodiment and test implementation example effect and to be described in detail the present invention.
Embodiment 1:
Rhizoma Atractylodis Macrocephalae 2000mg,
Fructus Corni 500mg,
Folic acid 0.3mg,
Vitamin B
62mg,
Vitamin B
120.003mg,
Vitamin B
13mg,
Vitamin B
23mg,
Nicotiamide 10mg,
Vitamin C 30mg,
Zinc lactate (in trace element zinc) 10mg,
Sodium selenate (in trace element-selenium) 0.02mg,
Ferric citrate (in trace elements iron) 10mg,
Calcium lactate (in element calcium) 600mg,
Magnesium lactate (in element magnesium) 200mg,
Retinol equivalent (vitamin A and/or beta-carotene) 300 μ g RE,
Vitamin D 0.002mg,
Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.
With said components further with the additive such as the aluminosilicate magnesium of appropriate amount, gather solvate 60 and propylene glycol mixes equably, with the gained mixture insert capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 2:
Rhizoma Atractylodis Macrocephalae 2000mg,
Fructus Corni 500mg,
Folic acid 0.3mg,
Vitamin B
62mg,
Vitamin B
120.003mg,
Vitamin B
13mg,
Vitamin B
23mg,
Nicotiamide 10mg,
Vitamin C 30mg,
Zinc lactate (in trace element zinc) 8mg,
Sodium selenate (in trace element-selenium) 0.02mg,
Ferric citrate (in trace elements iron) 10mg,
Chromium yeast (in trace element chromium) 0.02mg,
Calcium lactate (in element calcium) 600mg,
Magnesium lactate (in element magnesium) 200mg,
Retinol equivalent (vitamin A and/or beta-carotene) 300 μ g RE,
Vitamin D 0.002mg,
Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.
With said components further with the additive such as the aluminosilicate magnesium of appropriate amount, gather solvate 60 and propylene glycol mixes equably, with the gained mixture insert capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 3:
Rhizoma Atractylodis Macrocephalae 2000mg,
Fructus Corni 500mg,
Folic acid 0.3mg,
Vitamin B
62mg,
Vitamin B
120.003mg,
Vitamin B
13mg,
Vitamin B
23mg,
Nicotiamide 10mg,
Vitamin C 30mg,
Zinc lactate (in trace element zinc) 10mg,
Sodium selenate (in trace element-selenium) 0.02mg,
Ferric citrate (in trace elements iron) 10mg,
Chromium yeast (in trace element chromium) 0.02mg,
Sodium molybdate (in trace element molybdenum) 0.03mg,
Calcium lactate (in element calcium) 600mg,
Magnesium lactate (in element magnesium) 200mg,
Retinol equivalent (vitamin A and/or beta-carotene) 300 μ g RE,
Vitamin D 0.002mg,
Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.
With said components further with the additive such as the aluminosilicate magnesium of appropriate amount, gather solvate 60 and propylene glycol mixes equably, with the gained mixture insert capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 4:
Rhizoma Atractylodis Macrocephalae 2000mg,
Fructus Corni 500mg,
Folic acid 0.3mg,
Vitamin B
62mg,
Vitamin B
120.003mg,
Vitamin B
13mg,
Vitamin B
23mg,
Nicotiamide 10mg,
Biotin 0.01-0.1mg,
Vitamin C 30mg,
Zinc lactate (in trace element zinc) 10mg,
Sodium selenate (in trace element-selenium) 0.02mg,
Ferric citrate (in trace elements iron) 10mg,
Chromium yeast (in trace element chromium) 0.02mg,
Sodium molybdate (in trace element molybdenum) 0.03mg,
Calcium lactate (in element calcium) 600mg,
Magnesium lactate (in element magnesium) 200mg,
Retinol equivalent (vitamin A and/or beta-carotene) 300 μ g RE,
Vitamin D 0.002mg,
Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.
Above-mentioned component is further mixed with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount equably, again the gained mixture is processed 3 bag shot-like particles.Obey every day 3 times, obey a bag at every turn.
Embodiment 5:
Rhizoma Atractylodis Macrocephalae 300mg,
Fructus Corni 300mg,
Folic acid 0.1mg,
Vitamin B
60.5mg,
Vitamin B
120.001mg,
Vitamin B
10.5mg,
Vitamin B
20.5mg,
Nicotiamide 5mg,
Pantothenic acid 2mg,
Biotin 0.01mg,
Vitamin C 30mg,
Zinc lactate (in trace element zinc) 5mg,
Sodium selenate (in trace element-selenium) 0.015mg,
Ferric citrate (in trace elements iron) 5mg,
Chromium yeast (in trace element chromium) 0.015mg,
Sodium molybdate (in trace element molybdenum) 0.02mg,
Calcium lactate (in element calcium) 250mg,
Magnesium lactate (in element magnesium) 100mg,
Retinol equivalent (vitamin A and/or beta-carotene) 200 μ g RE,
Vitamin D 0.015mg,
Vitamin E (in the alpha-tocopherol equivalent) 5mg α-TE.
Above-mentioned component is further mixed with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount equably, again the gained mixture is processed 3 bag shot-like particles.Obey every day 3 times, obey a bag at every turn.
Embodiment 6:
Rhizoma Atractylodis Macrocephalae 15000mg,
Fructus Corni 10000mg,
Folic acid 1mg,
Vitamin B
610mg,
Vitamin B
120.025mg,
Vitamin B
120mg,
Vitamin B
220mg,
Nicotiamide 50mg,
Pantothenic acid 20mg,
Biotin 0.1mg,
Vitamin C 500mg,
Zinc lactate (in trace element zinc) 20mg,
Sodium selenate (in trace element-selenium) 0.1mg,
Ferric citrate (in trace elements iron) 20mg,
Chromium yeast (in trace element chromium) 0.15mg,
Sodium molybdate (in trace element molybdenum) 0.06mg,
Calcium lactate (in element calcium) 1000mg,
Magnesium lactate (in element magnesium) 300mg,
Retinol equivalent (vitamin A and/or beta-carotene) 800 μ g RE,
Vitamin D 0.01mg,
Vitamin E (in the alpha-tocopherol equivalent) 150mg α-TE.
Above-mentioned component is further mixed with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount equably, again the gained mixture is processed 3 bag shot-like particles.Obey every day 3 times, obey a bag at every turn, serve on 3, withdrew 2, obeyed again 3.
Confirm that through animal experiment this compositions belongs to nontoxic level; The crowd takes and does not also see toxicity.
Subordinate list 1: the young rat/mouse labyrinth test effect of this compositions and the Rhizoma Atractylodis Macrocephalae and Fructus Corni component and vitamin added elements component compares:
| Group | Medicine | Consumption | Sample number | The mistake percentage rate |
| The A group | Matched group | 0 | 12 | 21.6％ |
| The B group | The Rhizoma Atractylodis Macrocephalae and Fructus Corni group | Rhizoma Atractylodis Macrocephalae 100mg+ Fructus Corni 50mg/ days | 12 | 18.7％ |
| The C group | Vitamin+element set | Calcium 10mg+ magnesium 5mg+ zinc 0.1mg+ ferrum 0.1mg+ selenium 0.001mg+VB 10.1mg+VB 20.1mg+ nicotiamide 0.2mg+VB 60.08mg+VB 120.0001mg+ folic acid 0.008mg+VC1mg+VD0.0001mg+ (VA and/or beta-carotene) was by retinol equivalent 10 μ gRE+VE (in the alpha-tocopherol equivalent) 0.5mg α-TE/ days | 12 | 15.6％ |
| The D group | The Rhizoma Atractylodis Macrocephalae and Fructus Corni+vitamin+element set | Rhizoma Atractylodis Macrocephalae 100mg+ Fructus Corni 50mg+ calcium 10mg+ magnesium 5mg+ zinc 0.1mg+ ferrum 0.1mg+ selenium 0.001mg+ VB 10.1mg+VB 20.1mg+ nicotiamide 0.2mg+ VB 60.08mg+VB 120.0001mg+ folic acid 0.008mg+VC1mg+VD0.0001mg+ (VA and/or beta-carotene) was by retinol equivalent 10 μ gRE+VE (in the alpha-tocopherol equivalent) 0.5mg α-TE/ days | 12 | 14.9％ |
Subordinate list 2: this compositions and the Rhizoma Atractylodis Macrocephalae and Fructus Corni component and vitamin added elements component Aged Mice maze test effect compare:
| Group | Medicine | Consumption | Sample number | The mistake percentage rate |
| The A group | Matched group | 0 | 12 | 53.3％ |
| The B group | The Rhizoma Atractylodis Macrocephalae and Fructus Corni group | Rhizoma Atractylodis Macrocephalae 100mg+ Fructus Corni 50mg/ days | 12 | 34.6％ |
| The C group | Vitamin+element set | Calcium 10mg+ magnesium 5mg+ zinc 0.1mg+ ferrum 0.1mg+ selenium 0.001mg+ VB 10.1mg+VB 20.1mg+ nicotiamide 0.2mg+VB 60.08mg +VB 120.0001mg+ folic acid 0.008mg+VC1mg+VD0.0001mg+ (VA and/or beta-carotene) was by retinol equivalent 10 μ gRE+VE (in the alpha-tocopherol equivalent) 0.5mg α-TE/ days | 12 | 31.2％ |
| The D group | The Rhizoma Atractylodis Macrocephalae and Fructus Corni+vitamin+element set | Rhizoma Atractylodis Macrocephalae 100mg+ Fructus Corni 50mg+ calcium 10mg+ magnesium 5mg+ zinc 0.1mg+ ferrum 0.1mg+ selenium 0.001mg+ VB 10.1mg+VB 20.1mg+ nicotiamide 0.2mg+VB 60.08mg +VB 120.0001mg+ folic acid 0.008mg+VC1mg+VD0.0001mg+ (VA and/or beta-carotene) was by retinol equivalent 10 μ gRE+VE (in the alpha-tocopherol equivalent) 0.5mg α-TE/ days | 12 | 29.2％ |
Annotate: each group was tested by dosage feed in the table respectively in 60 days in subordinate list 1, the subordinate list 2; Consumption converts by per kilogram of body weight in the table.
Select 50 of newly-married healthy womens, 25 years old mean age, take this compositions continuously from beginning in pregnant preceding 3 months, followed up a case by regular visits to none routine birth defect in 6 months to the baby due.With associated materials statistics contrasts, birth defect youngster account for the newborn population sum 4-6% there were significant differences.
Can obviously find out from table 1, table 2; This compositions is through Chinese medicine component in rat/mouse labyrinth test and the compositions and the contrast of vitamin added elements component; The statistical result of mistake percentage rate, the function of this composition for improved memory is superior to Chinese medicine component or vitamin added elements component; With the blank group significant difference is arranged relatively.
Claims (5)
1. one kind is used to prevent birth defect and the pharmaceutical composition that improves memory, it is characterized in that it is processed by following raw materials according by weight ratio:
Rhizoma Atractylodis Macrocephalae 300-15000mg,
Fructus Corni 300-10000mg,
Folic acid 0.1-1mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Vitamin B
10.5-20mg,
Vitamin B
20.5-20mg,
Nicotiamide 5-50mg,
Pantothenic acid 0-20mg,
Biotin 0-0.1mg,
Vitamin C 30-500mg,
Zinc, in the zinc 5-20mg of element zinc,
Selenium, in the selenium 0.015-0.1mg of elemental selenium,
Ferrum, in the ferrum 5-20mg of elemental iron,
Chromium, in the chromium 0-0.15mg of elemental chromium,
Molybdenum, in the molybdenum 0-0.06mg of molybdenum,
Calcium, in the calcium 250-1000mg of element calcium,
Magnesium, in the magnesium 100-300mg of element magnesium,
Retinol equivalent 250-800 μ g RE,
Vitamin D 0.0015-0.01mg,
Vitamin E 5-150mg α-TE.
2. the pharmaceutical composition that is used to prevent birth defect and improvement memory according to claim 1 is characterized in that it is processed by following raw materials according by weight ratio:
Rhizoma Atractylodis Macrocephalae 300-15000mg,
Fructus Corni 300-10000mg,
Folic acid 0.1-1mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Vitamin B
10.5-20mg,
Vitamin B
20.5-20mg,
Nicotiamide 5-50mg,
Pantothenic acid 0-20mg,
Biotin 0-0.1mg,
Vitamin C 30-500mg,
Zinc, in the zinc 5-20mg of element zinc,
Selenium, in the selenium 0.015-0.1mg of elemental selenium,
Ferrum, in the ferrum 5-20mg of elemental iron,
Chromium, in the chromium 0.015-0.15mg of elemental chromium,
Molybdenum, in the molybdenum 0-0.06mg of molybdenum,
Calcium, in the calcium 250-1000mg of element calcium,
Magnesium, in the magnesium 100-300mg of element magnesium,
Retinol equivalent 250-800 μ g RE,
Vitamin D 0.0015-0.01mg,
Vitamin E 5-150mg α-TE.
3. the pharmaceutical composition that is used to prevent birth defect and improvement memory according to claim 1 is characterized in that it is processed by following raw materials according by weight ratio:
Rhizoma Atractylodis Macrocephalae 300-15000mg,
Fructus Corni 300-10000mg,
Folic acid 0.1-1mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Vitamin B
10.5-20mg,
Vitamin B
20.5-20mg,
Nicotiamide 5-50mg,
Pantothenic acid 0-20mg,
Biotin 0-0.1mg,
Vitamin C 30-500mg,
Zinc, in the zinc 5-20mg of element zinc,
Selenium, in the selenium 0.015-0.1mg of elemental selenium,
Ferrum, in the ferrum 5-20mg of elemental iron,
Chromium, in the chromium 0.015-0.15mg of elemental chromium,
Molybdenum, in the molybdenum 0.02-0.06mg of molybdenum,
Calcium, in the calcium 250-1000mg of element calcium,
Magnesium, in the magnesium 100-300mg of element magnesium,
Retinol equivalent 250-800 μ g RE,
Vitamin D 0.0015-0.01mg,
Vitamin E 5-150mg α-TE.
4. the pharmaceutical composition that is used to prevent birth defect and improvement memory according to claim 1 is characterized in that it is processed by following raw materials according by weight ratio:
Rhizoma Atractylodis Macrocephalae 300-15000mg,
Fructus Corni 300-10000mg,
Folic acid 0.1-1mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Vitamin B
10.5-20mg,
Vitamin B
20.5-20mg,
Nicotiamide 5-50mg,
Pantothenic acid 0-20mg,
Biotin 0.01-0.1mg,
Vitamin C 30-500mg,
Zinc, in the zinc 5-20mg of element zinc,
Selenium, in the selenium 0.015-0.1mg of elemental selenium,
Ferrum, in the ferrum 5-20mg of elemental iron,
Chromium, in the chromium 0.015-0.15mg of elemental chromium,
Molybdenum, in the molybdenum 0.02-0.06mg of molybdenum,
Calcium, in the calcium 250-1000mg of element calcium,
Magnesium, in the magnesium 100-300mg of element magnesium,
Retinol equivalent 250-800 μ g RE,
Vitamin D 0.0015-0.01mg,
Vitamin E 5-150mg α-TE.
5. the pharmaceutical composition that is used to prevent birth defect and improvement memory according to claim 1 is characterized in that it is processed by following raw materials according by weight ratio:
Rhizoma Atractylodis Macrocephalae 300-15000mg,
Fructus Corni 300-10000mg,
Folic acid 0.1-1mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Vitamin B
10.5-20mg,
Vitamin B
20.5-20mg,
Nicotiamide 5-50mg,
Pantothenic acid 2-20mg,
Biotin 0.01-0.1mg,
Vitamin C 30-500mg,
Zinc, in the zinc 5-20mg of element zinc,
Selenium, in the selenium 0.015-0.1mg of elemental selenium,
Ferrum, in the ferrum 5-20mg of elemental iron,
Chromium, in the chromium 0.015-0.15mg of elemental chromium,
Molybdenum, in the molybdenum 0.02-0.06mg of molybdenum,
Calcium, in the calcium 250-1000mg of element calcium,
Magnesium, in the magnesium 100-300mg of element magnesium,
Retinol equivalent 250-800 μ g RE,
Vitamin D 0.0015-0.01mg,
Vitamin E 5-150mg α-TE.
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| Title |
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| 王杰等.营养素参考值在食品营养标示中的应用.《中华预防医学杂志》.2006,第40卷(第1期),62-64. * |
| 齐玉歌.浅谈中药与维生素的相互作用.《山西职工医学院学报》.2007,第17卷(第3期),42-43. * |
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