CN101374936A - Enhanced activity biocidal hyrogen peroxide composition - Google Patents
Enhanced activity biocidal hyrogen peroxide composition Download PDFInfo
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- CN101374936A CN101374936A CNA2007800031328A CN200780003132A CN101374936A CN 101374936 A CN101374936 A CN 101374936A CN A2007800031328 A CNA2007800031328 A CN A2007800031328A CN 200780003132 A CN200780003132 A CN 200780003132A CN 101374936 A CN101374936 A CN 101374936A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
- A01N57/10—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds
- A01N57/12—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds containing acyclic or cycloaliphatic radicals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/02—Anionic compounds
- C11D1/34—Derivatives of acids of phosphorus
- C11D1/342—Phosphonates; Phosphinates or phosphonites
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/02—Anionic compounds
- C11D1/34—Derivatives of acids of phosphorus
- C11D1/345—Phosphates or phosphites
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/36—Organic compounds containing phosphorus
- C11D3/361—Phosphonates, phosphinates or phosphonites
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/36—Organic compounds containing phosphorus
- C11D3/362—Phosphates or phosphites
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/39—Organic or inorganic per-compounds
- C11D3/3947—Liquid compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
- A61L2/186—Peroxide solutions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/22—Phase substances, e.g. smokes, aerosols or sprayed or atomised substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/20—Targets to be treated
- A61L2202/25—Rooms in buildings, passenger compartments
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- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- General Health & Medical Sciences (AREA)
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Abstract
The present invention relates to the biocidal use of a composition comprising hydrogen peroxide in a concentration of 0.05-50% (w/w) , and a compound with a structure according to Formula 1: (OH) (2-m) (X) (0)P-[ (O)p-(R')q-(CH(Y)-CH2-O)n-R]m, or a salt thereof, wherein X is H or OH; each Y is independently H or CH3; m is 1 and/or 2; each p and q are independently 0 or 1, with the proviso that when p is 0, q is 1; each n is independently 2-10; each R' is independently an alkylene radical containing 1-18 carbon atoms; each R is independently H or an alkyl radical containing 1-18 carbon atoms; and R' +R = 20; in a concentration of 0.01-60% (w/w) . The composition is advantageously used for any purpose where disinfecting and/or sanitizing activity, preferably combined with cleaning and/or bleaching and/or preservative activity, is required. The present invention further discloses an especially preferred composition for biocidal use comprising hydrogen peroxide in a concentration of 0.05-50% (w/w) and a compound with a structure according to Formula 2: (OH) (X) (O)P-O-(CH(Y)-CH2-O)n-R, or a salt thereof, wherein X is H or OH, H is H or CH3, n is 4-6, and R is an alkyl radical containing 4-16 carbon atoms, in a concentration of 0.01-60% (w/w) .
Description
The present invention relates to the field of sterilizing and cleaning, more clearly relate to the enhanced biocidal activity composition based on hydrogen peroxide, described hydrogen peroxide also has enhanced stability.
A large amount of classes of compounds demonstrate kill livestock thing or antimicrobial acivity in various degree.Especially in following field, need biocidal composition: to foodstuff surface (for example fruits and vegetables) cleaning and disinfection, in health care industry, F﹠B industry and household field to hard-surface cleaning and sterilization.
In several years, people's effort concentrates on to develop and be highly effective antimicrobial chemical under diluted situation in the past, and described chemical is hypotoxic to people and other animal, and is not environmentally harmful.
In known sterilizing agent and biocide, hydrogen peroxide demonstrates special potentiality, because degradation production water and oxygen are nontoxic and harmless to environment.And it also trends towards having the biocidal activity of wide spectrum.But under the situation of spectrum activity in having the situation of harmful organism its identity the unknown is important.Sterilizing agent based on hydrogen peroxide is applicable to many different application, is included in hospital, clinic, laboratory, dental clinic, family health care and the long-term care facility.They also can be used in uses in F﹠B processing and preparation, livestock industry, the hotel industry (hospitality industry) and is used for general sanitary measure.
For effect fast and effectively is provided, biocidal superoxol must use the hydrogen peroxide of relative high density.Yet under higher concentration, this solution may be limited by the hazardous goods rules, and operation and use and may need special measure.For example, under the concentration that is higher than about 8w/w% aqueous solution, it is corrosive that hydrogen peroxide is considered to, and also be strong oxidizer.Contain the solution that is less than about 8w/w% hydrogen peroxide because the security of its improvement but preferred.
With hydrogen peroxide as unique Biocidal compounds and contain that to account for total compound weight be not fully effectively during the composition sterilization solid surface of 7% hydrogen peroxide (for example need be washed and be sterilized surface) nearly.In fact, existence organic and/or mineral contaminants has reduced the fungicidal activity of many biocides (as the reagent based on superoxide), thereby causes lower fungicidal activity and the lower disinfecting power that comprises their composition.
Under the lower concentration (for example 3% w/w), hydrogen peroxide is a skin irritation not, but demonstrates lower fungicidal activity.For example, the logarithm that the solution that contains 3% w/w hydrogen peroxide reached greater than 6 in Staphylococcusaureus (streptococcus aureus) in 20 minutes consuming time reduces, and this is for many application overlong time.The concentration that improves hydrogen peroxide can improve disinfectant speed.For example, the hydrogen peroxide water-based solution of the 25%w/w logarithm that only needs to reach in 20 seconds greater than 6 in Staphylococcus aureus reduces.Yet solution is corrosive under this concentration and needs special operation steps.
Using another shortcoming of hydrogen peroxide composition is when not using the combination of stablizer or stablizer, and the water-based peroxide compositions peculiarly can decompose in the short relatively time period.
The hydrogen peroxide composition that some kinds of solution have the enhanced biocidal activity with acquisition is proposed in this area.
WO 97/31093 discloses the composition that comprises peroxygen bleach (for example hydrogen peroxide), amphoterics (for example trimethyl-glycine), glutaraldehyde and antimicrobial essential oil.
WO 01/65939 discloses hydrogen peroxide, benzene is pricked the bactericidal property of the combination of ammonium salt and inorganic phosphate sequestering agent.
US 6,479,454 and US 6,444,230 disclose peralcohol and amine oxide combination through improved antimicrobial acivity.
WO 03/067989 discloses the purposes based on the tensio-active agent of some anion sulfoacid with hydrogen peroxide combination.
It also is one object of the present invention that following composition is provided, and described composition uses alap concentration of hydrogen peroxide and/or the least possible other to kill livestock the thing additive and fabulous biocidal activity is provided.A purpose also provides following composition, described composition can not need with in the operation or the preventive measures in using and security measures and directly use, and after application, do not need flushing or only need wash on a small quantity.The present invention shows following composition exhibiting enhanced biocidal activity astoundingly, and described composition comprises the combination of hydrogen peroxide and some phosphoric acid salt or phosphonate compounds.Compare with the superoxol that does not contain described compound, described composition is significantly improving of exhibit stabilization also.
WO 2004/067194 relates to the waterborne compositions that is stabilized, and it contains hydrogen peroxide, formula (I): (HO)
(3-m)OP (R-(CH
2-CH
2-O)
n-R
1)
mOr (HO)
(3-m)OP (O-(CH
2-CH
2-O)
n-R
1)
mOr (HO)
(3-m)OP (O-R
1-(CH
2-CH
2-O)
n-H)
mEthoxylated fat family phosphorous-containing surfactants and at least a other detersive surfactant.The compound of discoverable type (I) composition (clear gel) with extraordinary aesthetic is provided and help this prescription in addition high temperatures (about 40 ℃, nearly 6 months).In addition, said composition is stable to light, and is especially stable to UV light.
WO 97/47718 discloses the thickening material that is used for aqueous hydrogen peroxide solution, and it guarantees that reliable and persistent viscosity sets, and makes that comprising spices is easy to and does not have a muddy risk.This thickening material comprises 10 to 90% fatty acid chain alkanol, 5 to 20% alkyl ether sulphate and optional reaching 5% alkyl ether phosphate and reach 60% alkyl polyglycol ether.
Yet, in these two files, do not mention the enhanced biocidal activity of the composition of the aliphatics phosphorous-containing surfactants/alkyl ether phosphate that comprises ethoxylation.In addition, the compound with formula 2 structures is clearly open in these files.
Therefore, first aspect present invention provides the purposes of following compound as biocidal composition, and described compound comprises the hydrogen peroxide of 0.05-50% (w/w) concentration, and 0.01-60% (w/w) concentration has a formula 1:(OH)
(2-m)(X) (O) P-[(O)
p-(R ')
q-(CH (Y)-CH
2-O)
n-R]
mThe compound or its salt of structure, wherein X is H or OH; Each Y is H or CH independently
3M is 1 and/or 2; Each p and q are 0 or 1 independently, and condition is that q is 1 when p is 0; Each n is 2-10 independently; Each R ' is independently for containing the alkylidene group of 1-18 carbon atom; Each R is H or the alkyl that contains 1-18 carbon atom independently; And R '+R≤20.
Said composition has fabulous biocidal activity astoundingly, in addition be diluted as the hydrogen peroxide that contains 0.05-8% and 0.01-10% have the compound of formula 1 structure the time also be like this.It also shows good stability in time.The combination of compounds of hydrogen peroxide and formula 1 provides than the more virtuous biocidal composition of composition that uses these two kinds of compounds to obtain separately.
Except as otherwise noted, the per-cent that uses in the whole text in the present invention is the weight percent based on the composition gross weight.
Comprise at all types microorganism, bacterium, yeast and fungi with at the biocidal activity of virus in the alleged in the whole text biocidal activity of the present invention.
Formula 1 relates to the heterogeneous mixture of compound two kinds of individualities, similar and compound.For example, heterogeneous mixture can contain following compound, and wherein the length of n value and/or alkylidene group and/or alkyl changes in different numerical ranges, and n value of stipulating among the present invention's this moment and the chain length of R ' and R are mean value.In addition, heterogeneous mixture can contain the monoesters of formula 1 and the mixture of diester.The monoesters of formula 1 or diester are that wherein n is respectively 1 or 2 compound.Preferably in this class mixture, monoesters is main kind, promptly constitutes at least 50%, preferably at least 60%, more preferably at least 70%, further more preferably at least 80%, most preferably at least 90% of this class mixture.
In the structure of preferred formula 1, X is OH, Y is H, n be 2-8, preferred 2-6, more preferably 4-6, most preferably 4 and/or R '+R be 4-18 carbon atom, preferably 4-16 carbon atom, more preferably 6-14 carbon atom, further more preferably 8-12 carbon atom, further more preferably 8-10 carbon atom.Also preferred R ' and R are the straight chain bases.In further preferred construction, the p value be 1 and the q value be 0.
The particularly preferred compound formation another aspect of the present invention that is used for purposes of the present invention.It is the compound with formula 1 structure, and wherein m is 1, p be 1 and q be 0, promptly 0.01-60% (w/w) concentration has a formula 2:(OH) (X) (O) P-O-(CH (Y)-CH
2-O)
nThe compound or its salt of the structure of-R, wherein X is H or OH, Y is H or CH
3, n is 4-8, and R is the alkyl that contains 4-18 carbon atom.
In the structure of preferred formula 2, X is OH, and Y is H, and n is 4-6, and preferred n is 4, and R contains 4-16 carbon atom, preferably 6-14 carbon atom, more preferably 8-12 carbon atom, the alkyl of 8-10 carbon atom most preferably.Also preferred R is a straight chained alkyl.
In the structure of particularly preferred formula 2, X is OH, and Y is H, and n is 4-6, and preferred n is 4, and R is the straight chained alkyl that contains 8-12 carbon atom, preferred 8-10 carbon atom.
The composition that is used for purposes of the present invention preferably can be used as enriched material and sells, and described enriched material contains hydrogen peroxide (concentration can change) and have the compound (concentration can change) of formula 1 structure in about 5-60% scope in about 10-50% scope.Described enriched material can suitably be diluted to and will be used for the final effective concentration of using.
After the dilution, effective concentration of hydrogen peroxide of composition can be 0.05-8% (w/w), preferred 0.1-5%, more preferably 0.2-3%, 0.3-2% most preferably.According to the desired use of composition, concentration of hydrogen peroxide can be in higher scope in (for example 1-8%) or the lower scope (for example 0.05-1%) change.Compound concentrations with formula 1 structure can be 0.01-10% (w/w), preferred 0.05-5%, more preferably 0.1-2%.
Hydrogen peroxide and compound concentrations with formula 1 structure are preferably selected in the following manner in the composition: hydrogen peroxide and have part by weight between the compound of formula 1 structure between 10 and 0.1, between preferred 5 and 0.2, most preferably change between 2 and 0.5.
In one embodiment of the invention,, the dried particles preparation forms composition of the present invention by being dissolved in the water.In this embodiment, hydrogen peroxide is produced by peralcohol such as SPC-D, Sodium peroxoborate monohydrate, sodium perborate tetrahydrate, sodium tetraborate decahydrate or its mixing.This makes it possible to use following solids composition, and described solids composition comprises compound that produces superoxide and the compound with structure of formula 1 or 2.
Simple formulation is used because hydrogen peroxide and the validity with combination of compounds of formula 1 structure, compound can be used as far as possible.For many application, must in composition, not replenish the extra compound of its biocidal activity of influence (enhancing).Therefore, in this class embodiment, composition is made of as the compound with biocidal activity hydrogen peroxide and the compound with formula 1 structure basically.
The biocidal activity that is used for the composition of purposes of the present invention is preferably measured by controlled sterilization suspension test, and described test is that (EN 1276: the quantitative suspension test of the evaluating chemical sterilizing agent that use food, industry, makeup and public sphere and the fungicidal activity of antiseptic-germicide: testing method and requirement) for European standard EN 1276 at chemostefilant and antiseptic-germicide.Effectively biocidal composition be with every milliliter 10
8The contact of the Staphylococcus aureus test suspension liquid of cfu provides at least after 1 minute log 3 reduces, preferred log at least 4 reduces, more preferably at least log 5 reduce, the composition that reduces of log 6 at least most preferably.
According to microorganism to be detected, may use fungi, yeast or the special-purpose suspension test of virus.For fungi or yeast, can use test according to European standard EN 1275, EN 1650 or EN13624.For virus, can use test according to European standard EN 14476.
At last, the test according to European standard EN 13704 is applicable to the spore activity extremely of estimating the chemostefilant that uses in food, industry, makeup and public sphere.
The preferably aqueous solution of thing peroxide compositions of killing livestock that is used for purposes of the present invention.
Examples for compounds with formula 1 structure is:
Uniqema：
Monafax 1214 aliphatics C8-10,4EO
Monafax 831 aliphatics
Basf：
Maphos 60A aliphatics C10 b-oxide monoesters
Maphos 58 aliphatics
Akzo：
Phospholan PE 169 C13 isotridecyl ether phosphates
Zschimmer & Schwarz：
Phosfetal 201 aliphatics C12 (mixture of monoesters and diester)
Phosfetal 213 aliphatics C18 (mixture of monoesters and diester)
Elementis：
SERVOXYL VPBZ 5/100, C12-C16 is based on 5 EO of coconut, monoesters and diester
SERVOXYL VPDZ 3/100, C13,3 EO, monoesters and diester (different tridecanol (C13) polyglycol ether (3 EO) phosphoric acid ester)
SERVOXYL VPDZ 6/100, C13,6 EO, monoesters and diester (different tridecanol (C13) polyglycol ether (6 EO) phosphoric acid ester)
SERVOXYL VMDZ 6/100, C13,6 EO, about 90% monoesters
SERVOXYL VPTZ 3/100, C8,3 oxyethane, monoesters and diester (2-Ethylhexyl Alcohol polyglycol ether (3 EO) phosphoric acid ester)
In preferred embodiments, the thing peroxide compositions of killing livestock that is used for purposes of the present invention is the i.e. aqueous solution of usefulness, and it contains the hydrogen peroxide of 0.1-5% and the compound with formula 1 structure of 0.05-5%.The pH of solution is 2-5 preferably.
This based composition also is very friendly to ecotope.
The particularly preferred compound that is used for purposes of the present invention be as
201, SERVOXYL VMDZ 6/100, SERVOXYL VPBZ 5/100
60A (BASF) and
The compound of 1214 (Uniqema).Especially,
The 1214th, have the biodegradable product of height of the extraordinary thing characteristic of killing livestock when making up, and obtained Ecolabelling (ecolabelling) from Swedish Society for Nature Conservation with hydrogen peroxide.This makes it possible to preferably use this solution under environmentally friendly situation.
Can in composition, add multiple other compound and put into practice effectiveness to strengthen it.
For example, can suitably add pH regulator acid (organic or inorganic) or alkali or suitable damping fluid to offer the selected pH of composition.Preferably, said composition has the pH in the acidic region, more preferably the pH of 1-8, the further more preferably pH of 1.5-6, the pH of 2-5 most preferably.
Composition also can comprise stabilizer of hydrogen peroxide, the form of positively charged ion screening agent (sequesteringagent) preferably, and more preferably the concentration with 0.01 to 20% (w/w) exists.The positively charged ion screening agent can be selected from ethylenediamine tetraacetic acid (EDTA) (EDTA), diethylene triaminepentaacetic acid(DTPA) (DTPA), N-(hydroxyethyl)-ethylenediamine tetraacetic acid (EDTA) (HEDTA), nitrogen base nitrilotriacetic (NTA), 2-hydroxyethyl imino-acetic acid (HEIDA) and salt thereof, or is selected from phenylformic acid, benzaminic acid, citric acid, phosphoric acid, imido grpup disuccinic acid (iminodisuccinic acid) and poly aspartic acid.More preferably, the positively charged ion sequestering agent is (colloid) stannate, further more preferably be selected from Acetanilide, disuccinic acid quadrol trisodium (trisodium ethylenediamine disuccinate, for example OctaQuest E30 or A65 (Octel)), phosphoric acid derivatives (Dequestphosphonate (Solutia) for example with 1 to 5 phosphate group, 1-hydroxy ethylene-1, the 1-bisphosphate, amino three (methylene radical phosphoric acid), diethylenetriamine-five (methylene radical phosphoric acid), 2-hydroxyethyl imido grpup two (methylene radical phosphoric acid) and ethylenediamine tetraacetic (methylene radical phosphoric acid)).
Composition also can comprise corrosion inhibitor, and preferably the concentration with 0.01% to 20% w/w exists.Preferably, corrosion inhibitor is selected from 1,2,3 benzotriazoles, Sodium orthomolybdate, Sodium Nitrite, sodium pyrosulfate, S-WAT, chromic salt, borate, phosphoric acid salt, polyphosphoric acid salt, Sodium Benzoate, Sunmorl N 60S and water glass.
Composition also can comprise the tensio-active agent compatible with hydrogen peroxide.This tensio-active agent can be anionic, cationic, non-ionic and/or the amphoteric tensio-active agent, preferred non-ionic and/or amphoteric tensio-active agent.Surfactant concentrations can from 0.005 to 40% w/w.
The exemplary nonionic surface active agent compatible with hydrogen peroxide is the Fatty Alcohol(C12-C14 and C12-C18) and/or the alkyglycosides of amine oxide, ethoxylation.
The preferred nonionic surface active agent compatible with hydrogen peroxide is amine oxide such as C8-C20 alkyl-dimethyl amine oxide and/or C8-C20 alkyl dihydroxy ethyl amine oxide, as dimethyl decyl amine oxide compound or dimethyl coco amine oxide compound (dimethylcocoamine oxide).
The preferred amphoterics compatible with hydrogen peroxide is trimethyl-glycine, as C8-C20 alkyl dimethyl trimethyl-glycine, C8-C20 alkylamidoalkyl propyl-dimethyl trimethyl-glycine is as cocamidopropyl propyl-dimethyl trimethyl-glycine (cocamidopropyl dimethyl betaine) and/or C8-C20 alkylthio trimethyl-glycine.
The contriver finds that shockingly the extraordinary biocidal activity of following composition exhibiting also shows compound and amine oxide and/or the trimethyl-glycine that extraordinary cleaning and oil removing ability, described composition comprise hydrogen peroxide and have formula 1 structure simultaneously.
In addition, composition can comprise at least a C1 to C8 alcohol, preferably exists with about concentration of 0.01 to about 10%w/w.Alcohol can be selected from phenylcarbinol, ethanol, propyl carbinol, 1-propyl alcohol, Virahol and glycol, for example ethylene glycol, propylene glycol and butyleneglycol.
Can in biocidal peroxide compositions, add other additive, thereby provide the characteristic that is fit to its purposes for composition.The example of this class additive is emulsifying agent, solvent, hydrotrote, glycerine, food flavouring, painted chemical, antiseptic-germicide, defoamer and corrosion inhibitor.
The invention provides the purposes that biocidal hydrogen peroxide composition is used for needs sterilization and/or the active any purpose of sanitary measure.Composition also can be advantageously used in following purpose, and described purpose also needs cleaning and/or bleaching and/or anticorrosion activity except that antimicrobial activity.Purposes according to the present invention comprises and being contacted with biocidal hydrogen peroxide composition by the substrate of microbial contamination suspecting.Because the validity of composition does not need to grow 1-5 minute duration of contact usually.This purposes comprises as the liquid of sterilization and sterilization flushing and cleaning with as the purposes of sterilization, cleaning and sanitizer (for example disinfectant soap).
The thing peroxide compositions of killing livestock especially can be used for following application, the important point is to provide sterilization and/or sanitary measure activity with the gentleest as much as possible reagent in the described application, preferably with cleaning and/or bleaching and/or anticorrosion active combination, for example cosmetic use, pharmaceutical use, personal care, mouth care, food, clean room etc.Do not wash after also being preferred for using or the seldom application of flushing, or the solution application that can contact with food.
Owing to kill livestock the thing peroxide compositions be nonirritating, do not have smell or volatile gases and be friendly, so be suitable for most the situation (worker's safety has high priority under this situation) that the user do not wear any protective clothing yet or be suitable for the individual most using as wound disinfection or prevention of gingivitis to skin.
The invention still further relates to purposes and the purposes by with the form of dipping use of thing peroxide compositions in the particular device example of killing livestock, as be used for room disinfectant spraying equipment (for example spray bottle, aerosol canister, aerosol produce equipment).
The preferable use of biocidal hydrogen peroxide composition relates to the purposes as skin antiseptic, preferred hand disinfectant.
For strengthen as skin antiseptic put into practice effectiveness and validity, can in composition, add the various skin nursing agent.Skin-care agent can be selected from glyceryl ester, Sorbitol Powder, Viscotrol C, (water-soluble) silicon, wallantoin, cation type polymer, lanolin and derivative and hexadecanol.
Composition also can comprise the tensio-active agent of non-ionic type to improve the drying of wetting capacity and enhancing hand.Can also remove particular case interpolation fat, oil and/or household cleanser and degreaser, for example negatively charged ion, nonionic or amphoterics or the alcohol of fat and removal spot at needs.
Existing skin antiseptic product (it typically contains alcohol, iodine/iodophor, chlorhexidine gluconate (CHG), oxybenzene compound, quarternary ammonium salt compound or its combination of high density) on the contrary the problem that has is them sacrifice for the skin mildness usually antimicrobial activity or.For example, can cause higher sterilisation level although improve the concentration of activeconstituents, the concentration that this class is higher often causes higher skin irritation.
Skin of the present invention (hand) antiseptic composition can exist the place that needs advantageously to replace this class to be developed to the sterilizing agent that reaches high level disinfection.
The composition that is used for purposes of the present invention can provide enough sterilisation level skin irritation not simultaneously.Said composition is nonirritating, because the tensio-active agent packing of its low-level hydrogen peroxide, gentleness and other gentle additive that can be used as mentioned above of lower concentration.Solution has broad spectrum of activity, and described active degree unexpectedly provides the fungicidal activity of individual composition.There is synergistic effect in the composition of solution of the present invention, thereby the effective sterilizing agent that is applicable to skin is provided.
In preferred embodiments, provide composition, wherein avoid using antimicrobial chemical as disinfectant soap, as Triclosan, Chlorhexidine, PCMX etc.Soap can be configured to gel-like soap, spraying soap or boty foam.The soap that it generally can be used as sterilization and cleaning skin or hair (shampoo) is used for hand or face more specifically, maybe can be used as the animal shampoo.
Extra tensio-active agent as the biocidal capability of further raising soap, soap can preferably contain trimethyl-glycine, as the alkyl dimethyl trimethyl-glycine, alkylamidoalkyl propyl-dimethyl trimethyl-glycine (as cocamidopropyl propyl-dimethyl trimethyl-glycine) and/or alkylthio trimethyl-glycine, and/or amine oxide, as alkyl dimethyl amine oxide and/or alkyl dihydroxy ethyl amine oxide, has the alkyl dimethyl amine oxide of 10-18 carbon atom as alkyl wherein, as dimethyldecylamine oxide, dimethyl cocounut oil amine oxide (dimethylcocoamine oxide) and/or dimethyl-tetradecylamine oxide (dimethylmyristylamine oxide).
The preferred purposes of another of composition relate in dentology purposes and as the purposes of mouthwass.Sterilization in mouth and the oral cavity and inflammation control remain important field, and are ruled by the product based on chlorine, pure and mild phenol till today.Many these products have significant disadvantage and biological tissue are had negative impact.Composition of the present invention can replace this series products effectively.
In order to obtain to be used for the compositions useful of dentology and mouthwass, in composition, added multiple compound, to strengthen its antimicrobial effectiveness, for example antimicrobial essential oil of described multiple compound and zinc salt (being zinc chloride, zinc oxide, zinc lactate), or strengthen the compound put into practice effectiveness such as glycol, alcohol, edible tensio-active agent, food flavouring, spices etc.
The invention still further relates to the purposes that composition is used for the disinfectant purposes and preferably cleans substrate in addition.This can finish by substrate is contacted with the biocidal composition of significant quantity.Except that sterilization, for some substrate, composition is especially effectively simultaneous smell removal when removing spot and dirt.Substrate can be any surface, space, material, medical treatment device or apparatus, hospital device, the surface on wall, top ceiling and/or floor.For example, composition can be used for carpet sterilization and cleaning effectively.Preferred substrate is to suspect wherein the substrate that has (causing a disease) microorganism.
Composition can also be used for food antiseptic effectively, is used for meat, poultry and fish as scavenging solution,, is used for animal doctor and domestic animal and uses (as prevention and treatment mazoitis) and be used for water treatment and water sterilization as scavenging solution in brew-house and dairy farm.
In preferred embodiments, composition is provided as the scavenging solution that is used for machine or device.The latter's example is food processing apparatus, cutting machine, nozzle, brew-house's equipment, bakery equipment, dairy farm equipment, fruits and vegetables machining cell, fruit juice and soft drink equipment etc., medical treatment device and apparatus and household device.
In this embodiment, composition should hang down into bubble.Nonionic and/or amphoterics can be present in the composition, so it should not be the tensio-active agent of too high one-tenth bubble.The amine oxide and/or the trimethyl-glycine that preferably have the alkyl chain (for example 8-10 carbon atom) in the low scope, for example octyl group-and/or decyl dimethyl oxidation amine.Hang down into the bubble characteristic in order further to reach, the composition of liquid wash can replenish defoamer, as water-soluble silicone and/or have a froth breaking characteristic hang down into the non-ionic tensio-active agent of bubble, as alkyl poly alkylene glycol ether, for example be selected from from Zschimmer; The Propetal series of Schwarz.
Embodiment
Use controlled sterilization suspension test to come the fungicidal activity of test sample composition, described test is that (EN 1276: the quantitative suspension test of the evaluating chemical sterilizing agent that use food, industry, makeup and public sphere and the fungicidal activity of antiseptic-germicide: testing method and requirement) for European standard EN 1276 at chemostefilant and antiseptic-germicide.Adding every ml in the 8ml composition that will test contains and has an appointment 10
8The 1ml test suspension liquid of cfu test microbes, and add 1ml milli-Q water.In some experiments, in suspension, add protein load to simulate uncleanly physical condition according to EN 1276 steps.For clean condition is provided, add 0.3% bovine serum albumin, for dirty condition is provided, add 3% bovine serum albumin.
1, after 2 and 5 minutes duration of contact, measures the amount of great-hearted bacterium.
Similarly, use is designated as the test that is used for fungi or virus and tests fungicidal and viricidal activity.For fungi or yeast, use test according to European standard EN 1275, EN 1650 or EN13624.For virus, use test according to European standard EN 14476.
The biocidal activity of using the sterilization suspension test that adapts with the European standard EN 12054 that is used for chemostefilant and antiseptic-germicide to test some compositions is in particular for the wiping hand liquid (handscrab) and the Liquid soap (handwash) of hygiology and surgery.Every ml is contained 1 x 10 at least
8The 1ml test suspension liquid of cfu bacterium mixes with the composition that 9ml will test.At first come its counting by initial suspension being diluted to isarithmic level.For wiping the test of hand liquid, use undiluted test suspension liquid.For the Liquid soap test, use the hard water dilution.
Embodiment 1
Test the biocidal activity of multiple composition and (no any interpolation can the commercial H that obtains except that stablizer with reference liquid
2O
2Solution) compare.Tested composition comprises the aliphatic phosphate ester that has 8-10 carbon atom and 4 moles of ethylene oxide unit (EO), and for example Uniqema International is sold with trade name Monafax 1214.In addition, stabilizer of hydrogen peroxide exists with the form of disuccinic acid quadrol trisodium (Trisodium Ethylenediamine Disuccinate), and described disuccinic acid quadrol trisodium can derive from Octel with trade name OctaQuest (OQ).Change in the scope of the pH of this class solution between 2 and 4.5.Test result is shown in the following table 1.The result shows that the interpolation of Monafax has strengthened the biocidal activity of composition significantly.
Table 1
Test suspension liquid 1 minute 2 minutes 5 minutes
1.0％ H
2O
2+0.02％ OQ
Salmonella typhimurium 4.80E+08 >1000 >1000 >1000
Escherichia coli 6.00E+07 >1000 >1000 1000
Pseudomonas aeruginosa 1.25E+08 >1000 >1000 172
Staphylococcus aureus 5.35E+08 >1000 >1000 560
Enterobacter cloacae 7.50E+08 >1000 >1000 >1000
1.5％ H
2O
2+0.02％ OQ
Salmonella typhimurium 4.80E+08 >1000 >1000 1000
Escherichia coli 6.00E+07 >1000 1000 688
Pseudomonas aeruginosa 1.25E+08 46 13 0
Staphylococcus aureus 5.35E+08 >1000 1000 678
Enterobacter cloacae 7.50E+08 >1000 >1000 864
1.75％ H
2O
2+0.02％ OQ
Salmonella typhimurium 4.80E+08 >1000 >1000 >1000
Escherichia coli 6.，00E+07 >1000 >1000 408
Pseudomonas aeruginosa 1.25E+08 670 210 48
Staphylococcus aureus 5.35E+08 >1000 876 272
Enterobacter cloacae 7.50E+08 >1000 >1000 1000
2％ H
2O
2+0.02％ OQ
Salmonella typhimurium 4.80E+08 >1000 >1000 1000
Escherichia coli 6.00E+07 >1000 1000 576
Pseudomonas aeruginosa 1.25E+08 1000 650 2
Staphylococcus aureus 5.35E+08 >1000 528 192
Enterobacter cloacae 7.50E+08 >1000 1000 1000
0.6％ H
2O
2+0.7％ Monafax 1214+0.02％ OQ
Salmonella typhimurium 4.80E+08 0
Escherichia coli 6.00E+07 0
Pseudomonas aeruginosa 1.25E+08 0
Staphylococcus aureus 5.35E+08 0
Enterobacter cloacae 7.50E+08 0
1.0％ H
2O
2+1％ Monafax 1214+0.02％ OQ
Salmonella typhimurium 4.80E+08 0
Escherichia coli 6.00E+07 0
Pseudomonas aeruginosa 1.25E+08 0
Staphylococcus aureus 5.35E+08 0
Enterobacter cloacae 7.50E+08 0
1.0％ H
2O
2+0.5％ Monafax 1214+0.02％ OQ
Salmonella typhimurium 4.80E+08 0
Escherichia coli 6.00E+07 0
Pseudomonas aeruginosa 1.25E+08 0
Staphylococcus aureus 5.35E+08 0
Enterobacter cloacae 7.50E+08 0
1.5％ H
2O
2+0.1％ Monafax 1214+0.02％ OQ
Salmonella typhimurium 1.00E+08 0
Escherichia coli 4.00E+07 0
Staphylococcus aureus 1.35E+08 0
Enterobacter cloacae 1.15E+08 0
0.5％ H
2O
2+0.2％ Monafax 1214+0.02％ OQ
Salmonella typhimurium 1.00E+08 0
Escherichia coli 4.00E+07 0
Staphylococcus aureus 1.35E+08 0
Enterobacter cloacae 1.15E+08 0
0.5％ H
2O
2+0.5％ Monafax 1214+0.02％ OQ
Salmonella typhimurium 1.00E+08 0
Escherichia coli 4.00E+07 0
Staphylococcus aureus 1.35E+08 0
Enterobacter cloacae 1.15E+08 0
During no Monafax, only bacteria types seldom is presented in 5 minutes greater than the minimizing of log 5, and this is the testing standard of standard EN 1276.When Monafax is arranged, log 6 or even the minimizing of log 7 after 1 minute, have been reached.
Comprise 1% H
2O
2Can in 30 seconds, kill following biology with the composition of 1% Monafax: Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Enterococcus hirae, Proteus Vulgaris, Staphylococcus epidermidis, Streptococcus pyogenes, Salmonella typhimurium, Shigella sonnei, Lysteriamonocytogenes, Legionella pneumoniae, Campylobacter jejuni, Klebsiellapneumoniae, Enterococcus faecium, Proteus mirabilis, Saccharomycescerevisiae.
Embodiment 2
Use EN 1276 tests under the pH about 5 performance and the following two kinds of widely used nonionic surface active agent of Monafax 1214 to be compared: (C12-18 has 7 EO to the Fatty Alcohol(C12-C14 and C12-C18) Dehydol LT7 of 0.6% ethoxylation; Cognis) and the high HLB nonionic surface active agent Arlasolve 200 (polyoxyethylene isocetyl ether) of 0.7% Uniqema.Test result is shown in the following table 2.The biocidal activity that shows the composition contain Monafax significantly is better than containing the biocidal activity of the composition of the Fatty Alcohol(C12-C14 and C12-C18) of ethoxylation or high HLB nonionic surface active agent.
Table 2
Test suspension liquid 1 minute 2 minutes 5 minutes
1.5％ H
2O
2+0.1％ Monafax 1214+0.02％ OQ
Escherichia coli 4.00E+07 0
Staphylococcus aureus 1.35E+08 0
1.5％ H
2O
2+0.6％ Dehydol LT7+0.02％ OQ
Escherichia coli 1.30E+08 >500 96 12
Staphylococcus aureus 1.74E+09 220 196 60
1.5％ H
2O
2+0.7％ Arlasolve 200+0.02％ OQ
Escherichia coli 1.30E+08 >500 >500 48
Staphylococcus aureus 1.74E+09 304 204 72
Embodiment 3
The performance of solution of the present invention and the performance of following amine oxide are compared, it is that one group of prior art is known even still have the tensio-active agent of remarkable biocidal activity in the low concentration scope (for example US 6 in superoxol, 479,454 (Ecolab) and US 6,444,230 (Chemoxal)).
In order to simulate uncleanly physical condition, in bacterium test suspension liquid, add protein load according to EN 1276 steps.For clean condition is provided, add 0.3% bovine serum albumin, for dirty condition is provided, add 3% bovine serum albumin.With performance and the N of Monafax 1214, N-dimethyl decyl amine-N-oxide compound (the Barlox 10s of Lonza Ltd.) relatively.Use 1.2% H
2O
2With 0.6% tensio-active agent separately.The solution that contains Monafax has the pH about 2.3, and the solution that contains Barlox 10s has the pH about 5.Test result is shown in the following table 3.The biocidal activity that shows the composition that contains Monafax is significant.
Table 3
Test suspension liquid is clean dirty
2 minutes 5 minutes 2 minutes 5 minutes
Barlox 10s(Lonza)
Enterococcus hirae 3.80E+08 8 0 6 1
Bacillus cereus 2.20E+08 >300 >300 >300 >300
Candida albicans 3.00E+08 300 250 >300 >300
Staphylococcus aureus 5.50E+08 >300 >300 >300 >300
Lysteria monocytogenes 3.00E+08 >300 >300 >300 >300
Monafax 1214(Uniqema)
Lysteria monocytogenes 3.00E+08 3 0 0 0
Enterococcus hirae 2.00E+08 0 0 0 0
Escherichia coli 3.00E+08 0 0 0 0
Pseudomonas aeruginosa 1.00E+08 0 0 0 0
Staphylococcus aureus 5.50E+08 0 0 0 0
Enterobacter cloacae 3.00E+08 0 0 0 0
300 expression a large amount of bacterium colonies (overgrowth) that can not be counted
Embodiment 4
It is significantly more stable than the solution that only contains hydrogen peroxide and can the commercial stabilizer of hydrogen peroxide that obtains that experiment also shows solution of the present invention.Test exist can be commercial the stability of 0.6% superoxol during the stablizer that obtains.Testing setup be 37 ℃ 30 days.Test result is shown in the following table 4.Measure H with permanganate titration
2O
2Concentration.Blank only contains the H of the stablizer that has manufacturers (SolvayChemicals) interpolation
2O
2
The interpolation of Monafax 1214 has strengthened the stability of superoxol, in addition exist can be commercial also be like this during the stabilizer of hydrogen peroxide that obtains.
Table 4
Embodiment 5
Preparation contains 0.5% hydrogen peroxide, 0.5% aliphatic phosphate ester (Monafax 1214 of Uniqema International), transfers to the solution of pH 4.5 as 0.5% Acetanilide (Acetanilide) of stabilizer of hydrogen peroxide and 0.6% C10 alcohol b-oxide (8 moles of EO) (the Lutensol XL 80 of BASF) and with potassium hydroxide, and as the hand scrubbing agent of sterilizing.
Hydrogen peroxidase 10 .5%
Monafax 1214(Uniqema) 0.5％
Lutensol XL 80(BASF) 0.6％
Acetanilide (Acetanilide) 0.5%
Potassium hydroxide is to pH4.5
Demineralised water adds to 100%
Use the antimicrobial acivity of EN 12054 testing method test soln on S.aureus, P.aeruginosa, E.hirae and E.coli, described solution shows the minimizing greater than log 3, and it is the standard of hand antiseptic-germicide.
Embodiment 6
Preparation contains the antimicrobial hand soaps of following composition:
1.5% hydrogen peroxide
1.5% Monafax 1214 (aliphatic phosphate ester)
2% Tego Betaine F 50 (alkylamidoalkyl CAB)
1% Natrulon H-10 (polymerization glycerine)
With NaOH composition is buffered to pH 4.5
(EN 1276,5 minutes, the logarithm that is expressed as the colony-forming unit of every ml reduces the factor) is as follows for biocidal activity:
Embodiment 7
Preparation contains the machine washing fluid of following composition:
0.4％ Monafax 1214(Uniqema)
0.3％ Barlox 10s(Lonza Inc.)
0.5％ Propetal 120(Zschimmer & Schwarz)
0.05％ Surfadone LP 100(International Specialty Products)
0.2％ Dequest 2010(Solutia)
According to this liquid of EN 1276 standard testings, it shows following biocidal activity (logarithm that is expressed as the colony-forming unit of every ml reduces the factor):
Clean dirty
E.coli ATCC 25922 >5 >5
Pseudomonas aeruginosa ATCC 15442 >5 >5
Enterococcus hirae ATCC 10541 >5 >5
Embodiment 8
In tested composition as follows, the common available compound of a series of formula 1 of interpolation 0.8% in 1.5% superoxol.The log that table 5 is presented on the Staphylococcus aureus reduces.
The efficacy data of the multiple compound of table 5. formula 1
Compound L og reduces
Staph.aureus
Manufacturers's Class1 minutes 5 minutes
BASF Maphos 60A >6 >6
Zschimmer & Schwarz Phosfetal 201 5.5 >6
Elementis VPDZ 6/100 3.0 5.5
Elementis VPBZ 5/100 >6 >6
Embodiment 9
Preparation contains 2% H
2O
2With the composition of 1% Monafax 1214 and according to EN 14776 standard pins west virus (Feline Calici Virus) and adenovirus (Adenovirus) in vaccinia virus (Vacciniavirus), the cat card are tested:
EN 14476-chemostefilant and antiseptic-germicide-at kill the virus quantitative suspension test-testing method and the requirement (the 2nd period/the 1st step) of chemostefilant that uses in people's medicine and antiseptic-germicide.
Surprisingly, contain the effective viricidal activity of composition exhibiting (table 6) of Monafax, and standard can the commercial H that obtains
2O
2(not adding Monafax) causes low-down log to reduce (table 7).
Table 6
1 minute 3 minutes
Vaccinia virus log〉5.4
Western viral log in the cat card〉5.4
Adenovirus log〉5.4
Table 7
3 minutes 5 minutes 10 minutes
Viral 2% H in west in the cat card
2O
2Log 0.2 log 0.9
Adenovirus 2% H
2O
2Log 0.6 log 0.6
Adenovirus 3% H
2O
2Log 0.5 log 0.6
Embodiment 10
Preparation comprises 7% H
2O
2With the solution of 4% Monafax 1214, and further test according to European standard EN 1275, EN 1650 and EN 13624 at fungi.
Quantitative suspension test-the testing method and the requirement (the 1st section) of yeast activity killed on the basic fungicidal of EN 1275-chemostefilant and antiseptic-germicide-be used for evaluating chemical sterilizing agent and antiseptic-germicide or basis.
Quantitative suspension test-the testing method of the evaluating chemical sterilizing agent that use EN 1650-chemostefilant and antiseptic-germicide-food, industry, family expenses and public sphere and the Fungicidally active of antiseptic-germicide and requirement (the 2nd section, the 1st step).
Quantitative suspension test-the testing method of the Fungicidally active of the evaluating chemical sterilizing agent that EN 13624-chemostefilant and antiseptic-germicide-field of medicaments uses and requirement (the 2nd section, the 1st step).
Test result is shown in table 8 and the table 9.
Table 8. uses Candidaalbicans ATCC 12031 test results of 5 and 15 minute contact time under mimic cleaning and dirty condition
| 5 minutes | 15 minutes | ||
| EN 1275 | log 3.3 | log>5.3 | |
| EN 1650/EN 13624 | Clean | log 3.2 | log>5.3 |
| EN 1650/EN 13624 | Dirty | log 2.5 | log>5.3 |
Table 9. uses Aspergillus niger ATCC 16404 test results of 5 and 15 minute contact time under mimic cleaning and dirty condition
| 5 minutes | 15 minutes | ||
| EN 1275 | log 4.5 | log>5.4 | |
| EN 1650/EN 13624 | Clean | log>5.4 | log>5.4 |
| EN 1650/EN 13624 | Dirty | log 4.4 | log>5.4 |
Claims (25)
1. following composition is as the purposes of biocidal composition, and described composition comprises the hydrogen peroxide of 0.05-50% (w/w) concentration, and 0.01-60% (w/w) concentration has a formula 1:(OH)
(2-m)(X) (O) P-[(O)
p-(R ')
q-(CH (Y)-CH
2-O)
n-R]
mThe compound or its salt of structure, wherein X is H or OH; Each Y is H or CH independently
3M is 1 and/or 2; Each p and q are 0 or 1 independently, and condition is that q is 1 when p is 0; Each n is 2-10 independently; Each R ' is independently for containing the alkylidene group of 1-18 carbon atom; Each R is H or the alkyl that contains 1-18 carbon atom independently; And R '+R≤20.
2. according to the purposes of claim 1, the described compound that wherein has the structure of formula 1 be wherein m be 1 compound and wherein m be the mixture of 2 compound, wherein m be 1 described compound constitute described mixture at least 50%, preferably at least 60%, more preferably at least 70%, further more preferably at least 80%, most preferably at least 90%.
3. according to the purposes of claim 1, the described compound that wherein has the structure of formula 1 is that wherein m is 1 compound.
4. according to each purposes of claim 1-3, wherein X is that OH and Y are H.
5. according to each purposes of claim 1-4, wherein n is 2-8, preferred 2-6, more preferably 4-6, most preferably 4.
6. according to each purposes of claim 1-5, wherein R '+R is 4-18 carbon atom, preferred 4-16 carbon atom, more preferably 6-14 carbon atom, further more preferably 8-12 carbon atom, further more preferably 8-10 carbon atom.
7. according to each purposes of aforementioned claim, wherein R ' and R are the straight chain bases.
8. according to each purposes of claim 1-7, wherein p be 1 and q be 0.
9. according to each purposes of aforementioned claim, wherein concentration of hydrogen peroxide is 0.05-10% (w/w), preferred 0.1-7%, more preferably 0.2-5%, 0.3-3% most preferably.
10. according to each purposes of aforementioned claim, the described compound concentrations that wherein has the structure of formula 1 is 0.01-10% (w/w), preferred 0.05-5%, 0.1-2% most preferably.
11. according to each purposes of aforementioned claim, wherein hydrogen peroxide and the following selection of described compound concentrations: hydrogen peroxide and have weight ratio between the described compound of structure of formula 1 between 10 and 0.1, between preferred 5 and 0.2, more preferably change between 2 and 0.5 with structure of formula 1.
12. according to each purposes of aforementioned claim, wherein said hydrogen peroxide is by the compound formation that produces superoxide.
13. according to each purposes of aforementioned claim, wherein said composition has 0-9, preferred 1.5-7, the more preferably pH of 2-5.
14. according to each purposes of aforementioned claim, wherein said composition also comprises stabilizer of hydrogen peroxide, the preferred cationic sequestering agent, and more preferably the concentration with from 0.01 to 20% (w/w) exists.
15. according to each purposes of aforementioned claim, wherein said composition also comprises non-ionic and/or amphoterics, preferably the concentration with from 0.005 to 40% (w/w) exists.
16. according to the purposes of claim 15, wherein said tensio-active agent is amine oxide and/or trimethyl-glycine.
17. according to each purposes of aforementioned claim, wherein said composition also comprises corrosion inhibitor, preferably the concentration with from 0.01 to 20% (w/w) exists.
18. each is used for the purposes of any purpose according to aforementioned claim, described purpose need be sterilized and/or the sanitary measure activity, preferably with cleaning and/or bleaching and/or anticorrosion active the combination.
19. according to the purposes of claim 15 or 16, wherein said composition is a disinfectant soap, preferred gel-like soap, spraying soap or boty foam.
20. according to the purposes of claim 14-17, wherein said composition is the sterilising liq that is used for the sterilization of equipment or crust, preferably by to equipment or crust soaks or spraying realizes.
21. a composition, said composition comprise the hydrogen peroxide of 0.05-50% (w/w) concentration, and 0.01-60% (w/w) concentration has a formula 2:(OH) (X) (O) P-O-(CH (Y)-CH
2-O)
nThe compound or its salt of the structure of-R, wherein X is H or OH, H is H or CH
3, n is 4-6, and R is the alkyl that contains 4-18 carbon atom.
22. the composition of claim 21, wherein R contains 4-16 carbon atom, preferred 6-14 carbon atom, more preferably 8-12 carbon atom, the alkyl of 8-10 carbon atom most preferably.
23. claim 21 or 22 each compositions, wherein R is a straight chained alkyl.
24. each composition of claim 21-23, it also comprises non-ionic and/or amphoteric tensio-active agent and/or stabilizer of hydrogen peroxide.
25. each composition of claim 21-24 is used for the purposes of needs sterilization and/or the active any purpose of sanitary measure, described sterilization and/or sanitary measure active preferably with cleaning and/or bleaching and/or anticorrosion active the combination.
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| CN201310116264.9A CN103266029B (en) | 2006-01-13 | 2007-01-12 | The biocidal hydrogen peroxide composition of increased activity |
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|---|---|---|---|
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| EP06100346.3 | 2006-01-13 | ||
| EP06116746.6 | 2006-07-06 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103125522A (en) * | 2013-02-01 | 2013-06-05 | 光景生物科技(苏州)有限公司 | Sphoricidal chemical disinfectant containing peroxide and antioxidant |
| CN114395611A (en) * | 2021-12-30 | 2022-04-26 | 珠海天祥粤澳质量技术服务有限公司 | Method for evaluating sterilization effect of disinfectant on aspergillus brazilianus |
-
2007
- 2007-01-12 CN CNA2007800031328A patent/CN101374936A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103125522A (en) * | 2013-02-01 | 2013-06-05 | 光景生物科技(苏州)有限公司 | Sphoricidal chemical disinfectant containing peroxide and antioxidant |
| CN114395611A (en) * | 2021-12-30 | 2022-04-26 | 珠海天祥粤澳质量技术服务有限公司 | Method for evaluating sterilization effect of disinfectant on aspergillus brazilianus |
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