CN101362785B - Avermectin extraction technology and apparatus - Google Patents
Avermectin extraction technology and apparatus Download PDFInfo
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- CN101362785B CN101362785B CN2008101575195A CN200810157519A CN101362785B CN 101362785 B CN101362785 B CN 101362785B CN 2008101575195 A CN2008101575195 A CN 2008101575195A CN 200810157519 A CN200810157519 A CN 200810157519A CN 101362785 B CN101362785 B CN 101362785B
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- methyl alcohol
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- avrmectin
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Abstract
The invention relates to an extraction technique for avermectin and a device thereof. Mycelia of the avermectin after being dried is put into a leaching column and is soaked statically in alcohol for 1 hour to 2 hours firstly; then methanol or ethanol is continuously added from the top end of the leaching column for dynamic elution; leaching liquid is continuously collected from a liquid outlet at the lower part of the leaching column; when avermectin residues in the effluent liquid after elution is less than 100u/mg, the adding of alcohol is stopped; nitrogen is pumped from the top end of the leaching column to extrude all rest leaching liquid in the leaching column; steam enters from a sieve plate of the leaching column; by connecting a condenser with a gas collection opening at the upper part of the leaching column, the recycling and utilization of the methanol or the ethanol are carried out. The dynamic elution and a closed leaching and filtering system of the technique of the invention overcome the defects of a plate filtration production technique, can reduce the leakage and use amount of menstruum and can shorten production period and lower production cost.
Description
Technical field
The present invention relates to biological pesticide products production field, particularly a kind of avermectin extraction technology and device.
Background technology
Along with the raising of people's living standard with to the demand of pollution-free food, biological pesticide gains great popularity in current agricultural chemicals market, and Avrmectin is a most popular and purposes biological pesticide product the most widely in the current biological pesticide market.
As a kind of novel biopesticide, Avrmectin has efficiently, the characteristic of low toxicity, wide spectrum, and various insects, mite and zooparasite are all had stronger insecticidal activity; The insecticidal mechanism uniqueness can be blocked the nerve conduction of invertebrates, and efficiency time is long; Easily degraded does not pollute the environment in soil and water.Therefore, it is the biological pesticide product that has development potentiality.
In present avermectin extraction technology process, mycelium will be used Plate Filtration then with 4-8 times of methyl alcohol or ethanol stirring and leaching 2-3 hour, collect vat liquor, mycelium after the filtration is again with methyl alcohol or ethanol stirring and leaching, Plate Filtration then, three to four times so repeatedly.
Adopt the lixiviate of this kind mode, defective is that the production cycle is long, and the Plate Filtration solvent leaks many, exists potential safety hazard many, also easily environment is polluted.Simultaneously, in the leaching process, methyl alcohol or ethanol consumption are big, for the 12-24 of mycelium weight doubly, and because Plate Filtration is non-closed-loop operation, in the Plate Filtration process, material contacts with atmosphere, methyl alcohol or ethanol volatilization are serious, and the production environment smell is heavier, works the mischief to the worker is healthy.
CN1923840 (200610048349.8) discloses a kind of avermectin extraction technology, it be with the dried mycelium of Avrmectin and methyl alcohol or ethanol with 1: 5～1: 10 weight ratio in the lixiviate in-tank mixing, after continuing to stir 3～6 hours under 20～25 ℃ of temperature, make vat liquor; Under 0.1～0.6Mpa pressure, be that the filter membrane system of 10 μ m～2nm filters with vat liquor again by the aperture; Send into the work in-process system of processing by the filtrate of filter membrane system, a raffinate part is returned the lixiviate jar, and another part by the filter membrane system circulating filtration, filters when finishing residue in the emptying lixiviate jar behind recycle pump.
In sum, seek a kind of airtight lixiviate and filter operating system, shorten the production cycle, reduce methyl alcohol or ethanol consumption, reduce its volatilization, increase yield, reducing production costs is the problem that urgent need will solve in the Avrmectin production.
Summary of the invention
The purpose of this invention is to provide a kind of avermectin extraction technology, to solve the technical problem that exists in the existing production.
The present invention also provides a kind of avermectin extraction technology specific equipment.
Technical scheme of the present invention is as follows:
A kind of avermectin extraction technology may further comprise the steps:
(1) the Avrmectin mycelium after will drying drops in the lixiviate post, earlier with 1-2 times of methyl alcohol or ethanol static immersing 1-2 hour, carry out dynamic desorption from lixiviate capital end adding methyl alcohol or ethanol continuously then, collect vat liquor continuously by lixiviate post bottom liquid outlet, methyl alcohol that dynamic desorption is used or ethanol are 6-8 times of Avrmectin mycelium weight.
(2) when Avrmectin is residual in the effluent liquid of wash-out when being lower than 100u/mg, stop to add methyl alcohol or ethanol, feeding nitrogen from lixiviate post item end all extrudes the residue vat liquor the lixiviate post, sieve plate from the lixiviate post feeds steam down then, the volatilization of being heated of methyl alcohol that adsorbs in the Avrmectin mycelium or ethanol, collection and confinement of gases mouth by lixiviate post top connects that condenser carries out methyl alcohol or alcoholic acid reclaims, and is recycling.
Preferably, in the above-mentioned steps (1), methyl alcohol or alcoholic acid flow velocity per hour are 1-1.5M when carrying out dynamic desorption
3
On the other hand, in the above-mentioned steps (1), the 5-6 that reaches the Avrmectin mycelium weight when the consumption of methyl alcohol or total ethanol is the vat liquor collected of back doubly, is used for the Avrmectin mycelium is carried out static immersing in the time of can supplying lixiviate next time.
Avrmectin is residual in the effluent liquid described in the above-mentioned steps (2) when being lower than 100u/mg, stop charging (promptly stopping to add methyl alcohol or ethanol), when being meant effluent liquid content being lower than 100u/mg after testing, illustrating that Avrmectin in the Avrmectin mycelium is residual has been lower than in the extractible economic limit, this lixiviate end-of-job all extrudes vat liquor with nitrogen then.
Described in the above-mentioned steps (2) under the lixiviate post sieve plate effect of logical steam be methyl alcohol or the ethanol that enters heating Avrmectin mycelium and absorption thereof by steam, the volatilization of being heated of methyl alcohol or ethanol, collect a mouthful discharge back lixiviate post by the pure gas on lixiviate post top and enter condenser, meet the cold liquid that becomes and to collect.
The special-purpose lixiviate post of a kind of avermectin extraction technology, it is an airtight tank container, container head has pure import and nitrogen inlet, the alcohol import is used to add methyl alcohol or ethanol, there is sieve plate at container lower cover place, is covered with filter cloth on the sieve plate, and container bottom is provided with vat liquor outlet and steam inlet, container head has pure gas outlet, and pure gas exports external condenser.The vat liquor outlet is used to collect vat liquor, and pure gas outlet and condenser are used to reclaim methyl alcohol or ethanol.
Above-mentioned special-purpose lixiviate post is provided with agitator in airtight tank container.
Above-mentioned special-purpose lixiviate post, described condenser is connected to pure holding tank, is used to collect the methyl alcohol or the ethanol of recovery.
It is as follows that existing technology is compared excellent results of the present invention:
1, owing to adopt process using dynamic desorption of the present invention, can reduce by two to three repetitive operations, reduce methyl alcohol or ethanol consumption, shorten the production cycle, every batch of material can shorten for 50% lixiviate production time.
2, owing to adopt the closed lixiviate to filter, can reduce the solvent that causes because of methyl alcohol or alcoholic acid volatilization leakage and lose, reduced production cost, improved Working environment simultaneously, it is healthy to help the worker.
3, realized that lixiviate and molten coal are recovered in the same equipment and operated, reduced the material transfer step, reduced menstruum volatilization loss simultaneously.
4. owing to adopt the closed lixiviate to filter, facility investment is few, long service life, and maintenance cost is far below sheet frame or membrane filtration system.
In a word, compare with existing technology, the dynamic desorption of technology of the present invention and the airtight application of extracted filtering system in the avermectin extraction technology process, overcome the drawback of Plate Filtration production technique, reduced the leakage of solvent, reduced the usage quantity of solvent, POI has shortened the production cycle, reduce production cost, improved Working environment.
Description of drawings
Fig. 1 is the structural representation of specific equipment lixiviate post of the present invention, wherein, and 1 airtight tank container, 2 pure imports, 3 nitrogen inlet, 4 agitators, 5 filter clothes, 6 steam inlets, the outlet of 7 vat liquors, 8 sieve plates, 9 pure vapor outlets, 10 condensers, 11 pure holding tanks.
Embodiment
The present invention will be further described below in conjunction with embodiment and accompanying drawing, but be not limited thereto.
The special-purpose lixiviate post of 1. 1 kinds of avermectin extraction technologies of embodiment
The structure of lixiviate post as shown in Figure 1, this lixiviate post is an airtight tank container 1, is provided with agitator 4 in airtight tank container 1.Airtight pot type container head has pure import 2 and nitrogen inlet 3, and pure import 2 is used to add methyl alcohol or ethanol, and there is sieve plate 8 at container lower cover place, be covered with filter cloth 5 on the sieve plate, container bottom is provided with vat liquor outlet 7 and steam inlet 6, and container head has pure gas outlet 9, and pure gas exports external condenser 10.Condenser 10 is connected to pure holding tank 11, is used to collect the methyl alcohol or the ethanol of recovery.The vat liquor outlet is used to collect vat liquor, and pure gas outlet and condenser are used to reclaim methyl alcohol or ethanol.
Embodiment 2: Avrmectin extracts
2000 kilograms of Avrmectin mycelium after the oven dry are dropped in the lixiviate post, add 2M
3Methyl alcohol soaked 1-2 hour, then with 1-1.5M per hour
3Flow velocity add methyl alcohol from capital end alcohol import 2, bottom vat liquor outlet 7 is collected effluent liquid and is entered down and go on foot operation, when load reaches 5-8M
3The time, effluent liquid collected apply mechanically in the container.When load reaches 15M
3The time, the Avrmectin content that begins to detect effluent liquid is at 120u/ml, 16M
3The Shi Jixu detection level stops charging at 90u/ml, with nitrogen the methyl alcohol in the lixiviate post is extruded, and then, from lixiviate column bottom steam inlet 6 logical steam, methyl alcohol gas enters external condenser 10 by top alcohol vapor outlet 9 and collects methyl alcohol.
Embodiment 3: Avrmectin extracts
1500 kilograms of Avrmectin mycelium after the oven dry are dropped in the lixiviate post, add 3M
3Methyl alcohol soaked 1-2 hour, then with 1-1.5M per hour
3Flow velocity add methyl alcohol from capital end alcohol import 2, bottom vat liquor outlet 7 is collected effluent liquid and is entered down and go on foot operation, when load reaches 4-6M
3The time, effluent liquid collected apply mechanically in the container.When load reaches 10M
3The time, the Avrmectin content that begins to detect effluent liquid is at 110u/ml, 12M
3The Shi Jixu detection level stops charging at 80u/ml, with nitrogen the methyl alcohol in the lixiviate post extruded, then, and the logical steam from the lixiviate column bottom, methyl alcohol gas enters external condenser by top end alcohol vapor outlet 9 and collects methyl alcohol.
Embodiment 4: Avrmectin extracts
As described in embodiment 2, institute's difference is, replaces methyl alcohol with ethanol, when effluent liquid to 15M
3The time, detect the Avrmectin content of effluent liquid and reduced to 80u/ml, stop charging, with nitrogen the ethanol in the lixiviate post is extruded, then, and the logical steam from the lixiviate column bottom, ethanol gas enters external condenser by top end alcohol vapor outlet 9 and collects ethanol.
Working process of the present invention can be summarized as: methyl alcohol or ethanol are imported in the lixiviate post continuously with pump, bottom vat liquor outlet 7 continuous dischargings, finish charging after testing after, compress into nitrogen from the top nitrogen inlet, the extrusion vat liquor.Feed steam then from the bottom, add thermal material, make the volatilization of methyl alcohol or ethanol, enter external condenser, it is standby to become liquid collecting after condensation.
Claims (5)
1. extraction method of abamectin may further comprise the steps:
(i) the Avrmectin mycelium after will drying drops in the lixiviate post, earlier with 1-2 times of methyl alcohol or ethanol static immersing 1-2 hour, carry out dynamic desorption from lixiviate capital end adding methyl alcohol or ethanol continuously then, collect vat liquor continuously by lixiviate post bottom liquid outlet, methyl alcohol that dynamic desorption is used or ethanol are 6-8 times of Avrmectin mycelium weight;
(ii) when Avrmectin is residual in the effluent liquid of wash-out when being lower than 100u/mg, stop to add methyl alcohol or ethanol, feeding nitrogen from lixiviate capital end all extrudes the residue vat liquor the lixiviate post, sieve plate from the lixiviate post feeds steam down then, the volatilization of being heated of methyl alcohol that adsorbs in the Avrmectin mycelium or ethanol, collection and confinement of gases mouth by lixiviate post top connects that condenser carries out methyl alcohol or alcoholic acid reclaims, and is recycling;
Described lixiviate post is on airtight tank container (a 1) top pure import (2) and nitrogen inlet (3) to be arranged, alcohol import (2) is used to add methyl alcohol or ethanol, there is sieve plate (8) at container lower cover place, be covered with filter cloth (5) on the sieve plate (8), container bottom is provided with vat liquor outlet (7) and steam inlet (6), container head has pure gas outlet (9), pure gas outlet (9) external condenser (10).
2. extraction method of abamectin as claimed in claim 1 is characterized in that, in the step (i), methyl alcohol or alcoholic acid flow velocity per hour are 1-1.5M when carrying out dynamic desorption
3
3. the described Avrmectin of claim 1 extracts special-purpose lixiviate post, it is characterized in that pure import (2) and nitrogen inlet (3) being arranged on airtight tank container (a 1) top, alcohol import (2) is used to add methyl alcohol or ethanol, there is sieve plate (8) at container lower cover place, be covered with filter cloth (5) on the sieve plate (8), container bottom is provided with vat liquor outlet (7) and steam inlet (6), and container head has pure gas outlet (9), pure gas outlet (9) external condenser (10).
4. extract special-purpose lixiviate post as Avrmectin as described in the claim 3, it is characterized in that in airtight tank container (1), being provided with agitator (4).
5. extract special-purpose lixiviate post as Avrmectin as described in the claim 3, it is characterized in that described condenser (10) is connected to pure holding tank (11).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101575195A CN101362785B (en) | 2008-10-06 | 2008-10-06 | Avermectin extraction technology and apparatus |
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| CN2008101575195A CN101362785B (en) | 2008-10-06 | 2008-10-06 | Avermectin extraction technology and apparatus |
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| CN101362785A CN101362785A (en) | 2009-02-11 |
| CN101362785B true CN101362785B (en) | 2011-04-20 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102617668B (en) * | 2012-02-29 | 2015-04-08 | 大庆志飞生物化工有限公司 | Production process of high-purity abamectin fine powder |
| CN102993252B (en) * | 2012-12-31 | 2015-07-29 | 齐鲁制药（内蒙古）有限公司 | A kind of extraction method of abamectin and device |
| CN106478369B (en) * | 2016-08-30 | 2019-09-03 | 齐鲁制药（内蒙古）有限公司 | A kind of the low energy consumption recovery system and technique of avermectin Extraction solvent |
| CN110422642A (en) * | 2019-08-14 | 2019-11-08 | 齐鲁制药（内蒙古）有限公司 | A kind of avermectin bacteria residue collection apparatus for temporary storage |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1923840A (en) * | 2006-09-27 | 2007-03-07 | 河北瑞通美邦工程有限公司 | Extraction technology of avermectin |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1923840A (en) * | 2006-09-27 | 2007-03-07 | 河北瑞通美邦工程有限公司 | Extraction technology of avermectin |
Non-Patent Citations (1)
| Title |
|---|
| 王斓等人.超声波提取阿维菌素B1a的工艺.《沈阳药科大学学报》.2007,第24卷(第3期),182-185. * |
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