CN101337099A - Pulse injection apparatus - Google Patents
Pulse injection apparatus Download PDFInfo
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- CN101337099A CN101337099A CNA200810063468XA CN200810063468A CN101337099A CN 101337099 A CN101337099 A CN 101337099A CN A200810063468X A CNA200810063468X A CN A200810063468XA CN 200810063468 A CN200810063468 A CN 200810063468A CN 101337099 A CN101337099 A CN 101337099A
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- 238000002347 injection Methods 0.000 title claims abstract description 70
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- 239000003708 ampul Substances 0.000 claims abstract description 22
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- 238000003860 storage Methods 0.000 claims description 28
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- 238000005516 engineering process Methods 0.000 description 11
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- 238000006073 displacement reaction Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 4
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Abstract
The invention discloses a pulse injection device which belongs to the technical field of the subcutaneous-administration device in the medical appliance. The pulse injection device comprises an ampoule mounted at the front end of a piezoelectric pulse push shot device and a drug storehouse. The ampoule comprises a cylinder body, wherein a minitype spray orifice is arranged at the front end part of the cylinder body, and an opening is arranged at the rear end thereof; a push rod is movably mounted in the cylinder body, and a piston is fixed at the front end of the push rod; and an interface which communicates with the drug storehouse is arranged on the front end wall of the cylinder body, and is positioned between the start position and the maximum stroke of the piston. The drug storehouse comprises a closed-type case body with a drug outlet, and a pressurizing system is mounted in the case body. A hose with a switch is sleeved between the drug outlet and the interface. The pulse injection device has the advantages of convenient drug fetch, high injection dosage, controllable injection depth, high injection dosage precision and controllable injection and drug release process.
Description
Technical field
The invention discloses a kind of pulse injection apparatus, belong to subcutaneous administration device technique field in the medical device.
Background technology
Transdermal drug delivery system is meant directly and makes medicine pass through each layer of skin in the skin surface administration, enters the novel form that the body circulation produces whole body or local therapeutic effects.As a kind of non-invasive route of administration, transdermal drug delivery system has remarkable advantages, is embodied in: drug absorption is not subjected to the influence at complicated factors such as intestinal traveling times of digestive tract interior pH value, food and medicine; Avoided the first pass effect of medicine at liver; Can produce lasting, constant and controlled injection speed and blood drug level, reduce administration number of times and dosage, thereby alleviate untoward reaction; Improved bioavailability of medicament; Agents area is at body surface, and use and interruption of the administration are convenient etc.Yet, since the natural skin barrier, the ability extreme difference of the penetrating skin of most drug molecule, and macromole hydrophilic medicament such as insulin are especially true.Therefore, the most universal present transdermal administration mode: the administering effect of patche is unsatisfactory.In order to overcome this obstacle, in recent years, the scientific research personnel develops multiple novel medicine-feeding technology in succession, promptly utilizes the technology change skin barrier of mechanical energy or the energy of increase drug molecule to increase transdermal release amount of medicine.The active technology of research comprises iontophoresis mount technology, ultrasonic technology and micropin technology and jet injection technology etc.
The jet injection technology is a kind of by spring or Compressed Gas generation high-speed jet, directly injects hypodermic medicine-feeding technology by miniature spray orifice.The jet injection origin can be traced back to the late 19th century, and a kind of technology of aquapuncture by name was delivered on medical journal at that time.The contemporary history that jet injection is applied to the medicine injection originates in the thirties in 20th century, and from that time, multiple jet injector begins to emerge and be applied to clinical practice.
The jet injector of a standard is made up of two parts usually: is used for sucking medicine, splendid attire medicine and launches the injection tube (ampoule) of medicine, and the device of propelling that can produce thrust when triggering.Propel device and comprise power set, flip flop equipment.Power is produced by the gas or the spring of compression usually.Produce propelling device and using repeatedly usually of power by spring, need the power resetting means.As the preposition patent of applicant " be used for needleless injector " (patent No.: ZL200620105022.5) described a kind of by split type helical spring resetting means; Preposition patent " the novel injector that is used for the Needleless injection " (patent No.: ZL200620140489.3) reach " device of propelling that is used for needleless injection of liquids " (patent No.: ZL200720192720.8) described a kind of the engagement with the bolt thread that has spring and carried out the device that power resets by elastic fin; Applicant's preposition patent " ampoule that is used for the needleless injection of liquids the device " (patent No.: ZL200720113453.0), described a kind of ampoule of many jet orifice structures of focus type, be beneficial in injection process, control injection depth.
Existing jet injection system still exists many deficiencies: (1) injection dose is the common problem of various jet injection drug-supplying systems for a short time, because jet injection is only once finished in the action, so general administration volume is at 0.1～1ml, the maximum injection volume is no more than 1.5ml in the existing product, if volume injected is too big, then can cause serious pain; (2) injection depth is uncontrollable, thus when injection depth dark excessively, when jet touches nervous system under the skin histology, can be with stronger pain, though many spray orifices of focus type in theory can controlling depth, because manufacturing difficulty is difficult to use in practice; (3) injected dose low precision, spring powered jet injector poor work stability is easy to cause the difference of dosage; (4) injection drug release process (speed, frequency) is uncontrollable, because the power source of syringe compression spring or its inherent characterisitic parameter of gases at high pressure (rigidity of spring or the pressure of gas) are that injector system self is given.The various shortcoming of above-mentioned jet injection system mainly causes because the power source design is not enough.
The variety of issue that produces at the deficiency of power source design, those skilled in the art propose to select for use the design of piezo-electric device as power source, as application number: 200610086860.7 patent, the characteristic of utilizing the dilatation of piezoelectric under driving voltage has been described, make piezo-electric device moment generation deformation by driving voltage, the interstitial fluid in the extruding lumen is clamp-oned playpipe with liquid, thereby the piston in the promotion playpipe produces an impetus by this piston.Though from the character narrate of this patent, it has more stable, the easier control of convenience, safety, injection flow and speed, and the big advantage of injected dose, in actual application, be difficult to implement, and the playpipe inconvenience of getting it filled.
Summary of the invention
In order to overcome the shortcoming of above-mentioned prior art, the invention provides a kind of pulse injection apparatus easily of getting it filled.
To achieve these goals, the technical solution adopted in the present invention is:
A kind of pulse injection apparatus, comprise and be installed in ampoule and the Drug Storage that the device front end is propelled in the piezoelectricity pulse, ampoule comprises that the front end end offers the cylindrical shell of miniature spray orifice, open rearward end, be movably installed with front end in the cylindrical shell and be fixed with the push rod of piston, offer the interface that is connected with Drug Storage on the described barrel front end wall, and this interface is between piston start bit and range; Drug Storage comprises the enclosed housing that offers medicine outlet, in this casing pressure charging system is installed, and is socketed with the flexible pipe of belt switch between medicine outlet and the interface.
Described pressure charging system comprises the Compressed Gas that is opened in the vertical gas injection port of casing, is sealed in the casing upper end by the movable sealing lid.
Described pressure charging system comprises the movable sealing lid that is installed in the casing upper end, and is connected with compression spring between movable sealing lid and the cabinet wall top.
Described piezoelectricity pulse is propelled device and is comprised being movably arranged on and propel the housing of pipe on the front inner wall, and propel in the cavity of pipe rear end piezoelectric pile is installed, this piezoelectric pile rear end is connected with external power source, and front end installation outer wall is with the push rod of back-moving spring; In the housing by after flange, big piston, valve piston are installed successively, and flange and the flexible connection of housing bottom inwall forward; Push rod is connected by the connecting rod that is located on the flange with big piston; Be perfused with hydraulic oil between big piston and the valve piston, and big piston, valve piston outer wall are equipped with sealing ring.
Described propelling between pipe front inner wall and the housing to being threaded; Between flange and the housing bottom inwall for being threaded.
Described connecting rod outer wall is provided with screw thread, and push rod top, big piston rear end all offer the screwed hole with the connecting rod threads engaged.
Offer oil filler point on the housing between described big piston, the valve piston.
The terminal outer wall of described push rod is provided with screw thread, offers the screwed hole with this threads engaged on the valve piston.
Described housing front end is equipped with adpting flange, and this adpting flange rear end inwall and housing front end outer wall flexibly connect by screw thread, and this adpting flange front inner wall and cylinder back-end outer wall flexibly connect by screw thread.
Described cylinder body outer wall is provided with the back-up ring that is positioned in the adpting flange end.
After adopting such scheme, the present invention offers the interface that is connected with Drug Storage on the barrel front end wall of ampoule, and this interface is between piston start bit and range, and near the piston start bit, such design has been avoided using check valve to control the difficulty of tiny flow quantity.Because Drug Storage comprises the enclosed housing that offers medicine outlet, in this casing pressure charging system is installed, and is socketed with the flexible pipe of belt switch between medicine outlet and the interface.During use, ampoule is installed to after the piezoelectricity pulse propels on the device, make its push rod that has piston be positioned at the position of required injected dose, open hosepipe switch again, owing in the Drug Storage pressure charging system is installed, make the interior medicine pressure of Drug Storage greater than a normal atmospheric pressure, therefore after hosepipe switch was opened, medicine flowed in the cylindrical shell automatically, treats that medicine is full of, the pulse of unlatching piezoelectricity is propelled device promotion push rod and is carried out the pulse injection first time, piston-advance is sealed interface during injection, and medicine is injected away from miniature spray orifice, and injection finishes, the occlusion pressure electric pulse is propelled device, push rod is withdrawn into the position of required injected dose, and in the process that retracts, the medicine in the Drug Storage flows in the cylindrical shell under the effect of pressure charging system and push rod suction smoothly, treat that medicine is full of, the pulse of unlatching piezoelectricity is propelled device promotion push rod and is carried out the pulse injection second time.The medicine of getting it filled continuously in this way, injecting in Drug Storage is used up, and the extremely convenient, fast and medicine of the whole process of getting it filled of Drug Storage has not a particle of waste in the process of getting it filled.
The invention will be further described below in conjunction with the drawings and specific embodiments.
Description of drawings
Fig. 1 is the structural representation of invention;
Fig. 2 is the enlarged drawing of ampoule among Fig. 1;
Fig. 3 is the enlarged drawing of Drug Storage among Fig. 1;
Fig. 4 is the Drug Storage structural representation of another structure;
Fig. 5 is the enlarged drawing that device is propelled in the piezoelectricity pulse among Fig. 1;
Fig. 6 is the structural representation that the pin injection ampoule is arranged.
The specific embodiment
Shown in Fig. 1,2,3,4,5, pulse injection apparatus of the present invention, comprise and be installed in ampoule 2 and the Drug Storage 3 that device 1 front end is propelled in the piezoelectricity pulse, ampoule 2 comprises that the front end end offers the cylindrical shell 9 of miniature spray orifice 4, open rearward end, be movably installed with front end in the cylindrical shell 9 and be fixed with the push rod 8 of piston 6, this is the common structure of pulse injection apparatus.
The improvement of this case is: offer the interface 5 that is connected with Drug Storage 3 on cylindrical shell 9 front bulkheads, and this interface 5 is between piston 6 start bits and range, near piston 6 places.Convenient for socket, interface 5 can be designed to above the form of cylindrical shell 9 outer walls.Drug Storage 3 comprises the enclosed housing 11 that offers medicine outlet 10, in this casing 11 pressure charging system is installed, and is socketed with the flexible pipe 12 of belt switch 13 between medicine outlet 10 and the interface 5.Interface 5 and Drug Storage 3 structural designs make pulse injection apparatus get it filled extremely convenient, fast and medicine has not a particle of waste in the process of getting it filled.Wherein, switch 13 can be selected rotational pressure formula switch for use.In actual use, if necessary, then can on casing 11 upper end sidewalls, offer medicine-pouring port.
Wherein, pressure charging system comprises the Compressed Gas 16 that is opened in casing 11 vertical gas injection ports 14, is sealed in casing 11 upper ends by movable sealing lid 15.Compressed Gas 16 makes medicine pressure in the Drug Storage 3 greater than a normal atmospheric pressure, after flexible pipe 12 switches 13 are opened, medicine is flowed in the cylindrical shells 9 automatically smoothly from Drug Storage 3.
Pressure charging system can also be to comprise the movable sealing lid 15 that is installed in casing 11 upper ends, and be connected with compression spring 17 between movable sealing lid 15 and the casing 11 inwall tops.Compression spring 17 herein is the same with above-mentioned Compressed Gas 16 effects, does not therefore do and gives unnecessary details.
The piezoelectricity pulse is propelled device 1 and is comprised being movably arranged on and propel the housing 21 of pipe on 22 front inner wall.That the location is installed is more accurate, firm in order to make, and propels and manages between 22 front inner wall and the housing 21 to being threaded.
Propel in the pipe 22 rear end cavitys piezoelectric pile 23 is installed, this piezoelectric pile rear end is connected with external power source, and front end is installed the push rod 24 that outer wall is with back-moving spring 25.
In the housing 21 by after flange 26, big piston 28, valve piston 29 are installed forward successively, and flange 26 flexibly connects with housing 21 bottom inwalls.That the location is installed is more accurate, firmly in order to make, between flange 26 and the housing 21 bottom inwalls for being threaded.Housing 21 front ends are equipped with adpting flange 30, and these adpting flange 30 rear end inwalls and housing 21 front end outer walls flexibly connect by screw thread, and these adpting flange 30 front inner wall and cylindrical shell 9 rear end outer walls flexibly connect by screw thread.Cylindrical shell 9 outer walls are provided with the back-up ring 7 that is positioned in adpting flange 30 ends.
Be perfused with hydraulic oil 20 between big piston 28 and the valve piston 29, and big piston 28, valve piston 29 outer walls are equipped with sealing ring 18.In order to make oiling convenient, offer oil filler point 19 on the housing 21 between big piston 28, the valve piston 29.
In order to make push rod 8 rapidly, continuously, accurately reset, push rod 8 terminal outer walls are provided with screw thread, offer the screwed hole 291 with this threads engaged on the valve piston 29.
When the present invention uses, the push rod 8 that will have piston 6 earlier is screwed onto on the screwed hole 291 of valve piston 29, again whole ampoule 2 is screwed onto on the adpting flange 30 of housing 21 front ends, and make piston 6 be positioned at the position of required injected dose, then Drug Storage 3 is connected with interface 5 on the ampoule 2 by flexible pipe 12, open flexible pipe 12 switches 13 then, owing in the Drug Storage 3 pressure charging system is installed, make medicine pressure in the Drug Storage 3 greater than a normal atmospheric pressure, therefore after flexible pipe 12 switches 13 are opened, medicine flows in the cylindrical shell 9 automatically, treat that medicine is full of, open piezoelectric pile 23 power switch, pulse signal (its frequency can be set arbitrarily) is after the high-voltage power amplifier amplifies, be applied on the piezoelectric pile 23, at the peak value place of pulse signal, piezoelectric pile 23 elongations promote push rod 24 earlier, big piston 28 moves forward, promote valve piston 29 by medium hydraulic oil 20 again and move forward, the push rod 8 that final promotion has piston 6 carries out the pulse injection first time.Because big piston 28 areas are greater than valve piston 29 areas, according to hydraulic principle, the displacement meeting that acts on big piston 28 is amplified in valve piston 29 by the ratio of area.Usually the displacement of piezoelectric pile 23 is at tens microns, and displacement reaches the millimeter level after amplifying.Piston 6 advances and seals interface 5 during injection, and medicine is injected away from miniature spray orifice 4.Because interface 5 is near piston 6 original positions, and its size will be much smaller than piston 6 strokes (interface 5 diameters are about piston 6 strokes of 1/10-1/5), the medicine that refluxes by interface 5 when piston 6 advances can be ignored.Injection finishes, and occlusion pressure pile 23 power switch, pulse signal disappear, piezoelectric pile 23 decompressions and shortening, and piston 6 resets under the reset response power of back-moving spring 25.In piston 6 reseting procedures, the medicine in the Drug Storage 3 flows in the cylindrical shell 9 under the effect of pressure charging system and push rod 8 suction smoothly, treats that medicine is full of, and opens piezoelectric pile 23 power switch once more, carries out the pulse injection second time.The medicine of getting it filled continuously in this way, injecting in Drug Storage 3 is used up, and the extremely convenient, fast and medicine of the whole process of getting it filled of Drug Storage 3 has not a particle of waste in the process of getting it filled.In addition, propel device 1 because the present invention is equipped with the piezoelectricity pulse of band displacement enlarging function, the injection dose is big, injection depth is controlled, injected dose precision height, injection drug release process are controlled.In actual injection, ampoule 2 and Drug Storage 3 can be used as disposable use consumptive material, and the piezoelectricity pulse is propelled device 1 and can be used repeatedly.As shown in Figure 6, this patent also can change the ampoule 2 that has miniature spray orifice 4 into pin injection ampoule 2.
Because the displacement that piezoelectric pile 23 produces very small (normally tens microns, through amplifying after between 0.5 to 2 millimeter), precision is very high, the precision of single pulse injection can be controlled at 0.5 to 10 receive rise between (concrete decide) by designing.And injection speed and frequency can conveniently regulate by pulse voltage, and the trace drug that is fit to very much the accurate control accuracy of needs is injected continuously, as medicines such as insulin, albumen, peptide and DNA.
The representative diameter of the spray orifice that uses in the jet injection system of present disposable injection is the 100-200 micron, less than the external diameter (external diameter of the pin of 21 grams is 810 microns) of standard subcutaneous injections device syringe needle.The jet injection depth ratio is bigger, and generally greater than 2 millimeters, jet velocity is bigger, and generally greater than 150m/s, so the degree of depth of transdermal is big, thereby the part patient feels pain.Correlational study shows: 80 microns of external diameters, length are that 150 microns micropin penetrates in people's the skin, can not cause pain, and on the contrary, the syringe needle of 26 grams (475 microns of external diameters) penetrates in people's the skin, can cause violent pain.And ampoule 3 miniature spray orifice 4 diameters of the application's patent design are at the 50-80 micron, and corresponding injection depth is generally less than 1 millimeter, can not cause pain.A typical ampoule 2 is of a size of cavity internal diameter 0.5-1 millimeter, piston 6 stroke 1-2 millimeters, interface 5 diameter 100-400 microns (1/101/5 piston stroke).A shot is below 1.5 microlitres.
The foregoing description only is used to the inventive concept of the present invention of explaining, but not to the qualification of rights protection of the present invention, allly utilizes this design that the present invention is carried out the change of unsubstantiality, all should fall into protection scope of the present invention.
Claims (10)
1, a kind of pulse injection apparatus, comprise and be installed in ampoule (2) and the Drug Storage (3) that device (1) front end is propelled in the piezoelectricity pulse, ampoule (2) comprises that the front end end offers the cylindrical shell (9) of miniature spray orifice (4), open rearward end, be movably installed with front end in the cylindrical shell (9) and be fixed with the push rod (8) of piston (6), it is characterized in that: offer the interface (5) that is connected with Drug Storage (3) on described cylindrical shell (9) front bulkhead, and this interface (5) is positioned between piston (6) start bit and the range; Drug Storage (3) comprises the enclosed housing (11) that offers medicine outlet (10), and this casing is equipped with pressure charging system in (11), and is socketed with the flexible pipe (12) of belt switch (13) between medicine outlet (10) and the interface (5).
2, pulse injection apparatus as claimed in claim 1 is characterized in that: described pressure charging system comprises the Compressed Gas (16) that is opened in the vertical gas injection port of casing (11) (14), is sealed in casing (11) upper end by movable sealing lid (15).
3, pulse injection apparatus as claimed in claim 1 is characterized in that: described pressure charging system comprises the movable sealing lid (15) that is installed in casing (11) upper end, and is connected with compression spring (17) between movable sealing lid (15) and casing (11) the inwall top.
4, pulse injection apparatus as claimed in claim 1, it is characterized in that: described piezoelectricity pulse is propelled device (1) and is comprised and be movably arranged on the housing of propelling on pipe (22) front inner wall (21), propel in the cavity of pipe (22) rear end piezoelectric pile (23) is installed, this piezoelectric pile rear end is connected with external power source, and front end is installed the push rod (24) that outer wall is with back-moving spring (25); In the housing (21) by after flange (26), big piston (28), valve piston (29) are installed forward successively, and flange (26) flexibly connects with housing (21) bottom inwall; Push rod (24) is connected by the connecting rod (27) that is located on the flange (26) with big piston (28); Be perfused with hydraulic oil (20) between big piston (28) and the valve piston (29), and big piston (28), valve piston (29) outer wall are equipped with sealing ring (18).
5, pulse injection apparatus as claimed in claim 4 is characterized in that: described propelling between pipe (22) front inner wall and the housing (21) to being threaded; Between flange (26) and housing (21) the bottom inwall for being threaded.
6, pulse injection apparatus as claimed in claim 4, it is characterized in that: described connecting rod (27) outer wall is provided with screw thread, and push rod (24) top, big piston (28) rear end offer screwed hole (241), the screwed hole (281) with connecting rod (27) threads engaged respectively.
7, pulse injection apparatus as claimed in claim 4 is characterized in that: offer oil filler point (19) on the housing (21) between described big piston (28), the valve piston (29).
8, pulse injection apparatus as claimed in claim 4 is characterized in that: the terminal outer wall of described push rod (8) is provided with screw thread, offers the screwed hole (291) with this threads engaged on the valve piston (29).
9, pulse injection apparatus as claimed in claim 4, it is characterized in that: described housing (21) front end is equipped with adpting flange (30), this adpting flange (30) rear end inwall and housing (21) front end outer wall flexibly connect by screw thread, and this adpting flange (30) front inner wall and cylindrical shell (9) rear end outer wall flexibly connect by screw thread.
10, pulse injection apparatus as claimed in claim 9 is characterized in that: described cylindrical shell (9) outer wall is provided with the back-up ring (7) that is positioned in adpting flange (30) end.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810063468A CN100591376C (en) | 2008-08-08 | 2008-08-08 | Pulse injection apparatus |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810063468A CN100591376C (en) | 2008-08-08 | 2008-08-08 | Pulse injection apparatus |
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| Publication Number | Publication Date |
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| CN101337099A true CN101337099A (en) | 2009-01-07 |
| CN100591376C CN100591376C (en) | 2010-02-24 |
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| CN200810063468A Active CN100591376C (en) | 2008-08-08 | 2008-08-08 | Pulse injection apparatus |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101554498B (en) * | 2009-05-21 | 2011-03-30 | 陈凯 | Needleless injection system used for continuously injecting animals |
| CN104096299A (en) * | 2014-07-23 | 2014-10-15 | 杭州电子科技大学 | Therapeutic equipment for jetting small quantity of medicines to human body |
| CN105709311A (en) * | 2016-01-18 | 2016-06-29 | 华南农业大学 | Needleless injector based on piezoelectric conversion and using method of needleless injector |
| CN106620966A (en) * | 2016-11-28 | 2017-05-10 | 合肥讯创信息科技有限公司 | Needleless injector achieving automatic resetting |
| CN107137158A (en) * | 2017-06-06 | 2017-09-08 | 浙江大学 | A kind of electronic detachable apparatus for having a needle injection |
| CN108784884A (en) * | 2018-06-19 | 2018-11-13 | 丁文铃 | A kind of herding needleless injector |
| CN110841150A (en) * | 2019-11-20 | 2020-02-28 | 泰州起点医疗科技有限公司 | Drug delivery device |
| CN111250183A (en) * | 2020-02-17 | 2020-06-09 | 北京中科生仪科技有限公司 | Liquid injection pump driving device for micro-fluidic system |
| WO2021027738A1 (en) * | 2019-08-09 | 2021-02-18 | Medical International Technologies (Mit China) Co., Ltd. | Single-charge multiple-injection needleless injector |
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2008
- 2008-08-08 CN CN200810063468A patent/CN100591376C/en active Active
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| CN101554498B (en) * | 2009-05-21 | 2011-03-30 | 陈凯 | Needleless injection system used for continuously injecting animals |
| CN104096299A (en) * | 2014-07-23 | 2014-10-15 | 杭州电子科技大学 | Therapeutic equipment for jetting small quantity of medicines to human body |
| CN105709311A (en) * | 2016-01-18 | 2016-06-29 | 华南农业大学 | Needleless injector based on piezoelectric conversion and using method of needleless injector |
| CN106620966A (en) * | 2016-11-28 | 2017-05-10 | 合肥讯创信息科技有限公司 | Needleless injector achieving automatic resetting |
| CN106620966B (en) * | 2016-11-28 | 2019-12-27 | 杨延萍 | Automatic reset needleless injector |
| CN107137158A (en) * | 2017-06-06 | 2017-09-08 | 浙江大学 | A kind of electronic detachable apparatus for having a needle injection |
| CN107137158B (en) * | 2017-06-06 | 2018-09-11 | 浙江大学 | A kind of electronic detachable apparatus for having needle injection |
| CN108784884A (en) * | 2018-06-19 | 2018-11-13 | 丁文铃 | A kind of herding needleless injector |
| WO2021027738A1 (en) * | 2019-08-09 | 2021-02-18 | Medical International Technologies (Mit China) Co., Ltd. | Single-charge multiple-injection needleless injector |
| CN110841150A (en) * | 2019-11-20 | 2020-02-28 | 泰州起点医疗科技有限公司 | Drug delivery device |
| CN111250183A (en) * | 2020-02-17 | 2020-06-09 | 北京中科生仪科技有限公司 | Liquid injection pump driving device for micro-fluidic system |
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