CN101322823A - Chinese medicine for dissipating cold, clearing heat, harmonizing nutrient and relieving pain and preparation thereof - Google Patents
Chinese medicine for dissipating cold, clearing heat, harmonizing nutrient and relieving pain and preparation thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine for dispersing cold and reducing fever as well as regulating the nutrient and relieving pain, and a preparation method thereof. The traditional Chinese medicine of the invention is prepared as capsules, granules and tablets by adopting 92.6g of cassia twig, 138.9g of radices paeoniae alba, 92.6g of hurricane lamp, 138.9g of rhizoma anemarrhenae, 92.6g of rhizoma atractylodis alba, 138.9g of herba ephedrae, 55.56g of rhizoma zingiberis, 92.6g of radix aconiti carmichaeli (prepared), 55.56g of liquorice, 92.6g of earthworm and auxiliary materials. The preparation method is that ten traditional Chinese medicines of the prescription are taken out and radices paeoniae alba and rhizoma zingiberis are crashed to form fine powder. Other eight Chinese medicines, such as rhizoma atractylodis alba, are decocted with water for two times. The decoction in the first time is carried out for two hours while the decoction in the second time is carried out for an hour and then the solution of decoction is combined, placed still and is filtered. Filtrate is condensed to be 50 DEG C and becomes an ointment with the relative density of 1.25-1.30. The fine powder of radices paeoniae alba and rhizoma zingiberis are added, evenly mixed, dried, crashed to form fine powder and then the fine powder is encapsulated or pressed to form the tablets. The radices paeoniae alba and rhizoma zingiberis are extracted to form volatile oil and other traditional Chinese medicines are decocted to be ointment and auxiliary materials are added to prepare granules. The traditional Chinese medicine preparation of the invention has reasonable prescription, accurate components and advanced medicine technology, and is applicable to sufferers with demands for different dosage forms and is convenient for medicine taking and carrying.
Description
Technical field
The present invention relates to Chinese medicine, particularly relate to a kind of dissipating cold, clearing heat for the treatment of rheumatic arthralgia and the Chinese medicine of seeking analgesic therapy and preparation method thereof.
Background technology
Rheumatic arthritis is commonly encountered diseases, frequently-occurring disease, and the traditional Chinese medical science is thought wind-cold damp pathogen not to the greatest extent, and heresy is the simultaneous occurrence of cold and heat syndromes of heat-transformation.Clinical characters is cold and heat and deposits that cold, two kinds of corresponding symptoms of heat occur simultaneously, and main clinical manifestation is that limbs joint is had a pain or swelling, local fear of cold, that touches is scorching hot, and a place or many places joint motion are dumb, the anemophobia aversion to cold, and the tongue fur HUANGBAI(sic) is held concurrently mutually, stringy pulse is tight or several, and the joint cold type of pain is heavy, and local happiness is warm, but with indistinctive fever, the thirsty drink of not liking, arthralgia is met cold increasing the weight of, inconvenience is bent and stretched in joint deformity, and the companion sees hectic fever in the afternoon, the night sweat that crouches night, red tongue, white and thin fur etc.At above-mentioned symptom verification treatment, suitable dissipating cold, clearing heat and battalion's analgesic therapy.Though traditional traditional Chinese medical science verification treatment obtains significant results, but traditional decoction, pill are in the majority, the dosage form dullness, and composition is indeterminate also inaccurate, makes extensive, quality is uncontrollable, carry and swallow all very difficultly, need to adopt modern pharmaceutical technology, impel the dosage form variation, need to improve conventional dosage forms, satisfy patient's different demands.
Summary of the invention
The technical problem to be solved in the present invention, it is reasonable to provide a kind of prescription, and composition is accurate, pharmaceutical technology advanced person, the multiple dosage form of suitable patient demand, Chinese medicine of the dissipating cold, clearing heat of symptomatic treatment rheumatic arthritis and battalion's analgesic therapy and preparation method thereof.
The technical scheme that adopts is:
The Chinese medicine of a kind of dissipating cold, clearing heat and battalion's analgesic therapy is to be mixed with capsule, granule and tablet by Ramulus Cinnamomi, the Radix Paeoniae Alba, Radix Saposhnikoviae, the Rhizoma Anemarrhenae, the Rhizoma Atractylodis Macrocephalae, Herba Ephedrae, Rhizoma Zingiberis, Radix Aconiti Lateralis Preparata, Radix Glycyrrhizae and Pheretima and adjuvant.Prescription is Ramulus Cinnamomi 92.6g, Radix Paeoniae Alba 138.9g, Radix Saposhnikoviae 92.6g, Rhizoma Anemarrhenae 138.9g, Rhizoma Atractylodis Macrocephalae 92.6g, Herba Ephedrae 138.9g, Rhizoma Zingiberis 55.56g, Radix Aconiti Lateralis Preparata 92.6g, Radix Glycyrrhizae 55.56g, Pheretima 92.6g.
Above-mentioned adjuvant comprises sucrose, dextrin, soluble starch, calcium sulfate, pregelatinized Starch, microcrystalline Cellulose, as the magnesium stearate and the Pulvis Talci of lubricant.
A kind of dissipating cold, clearing heat, Chinese medicinal preparation method with battalion's analgesic therapy, get Ramulus Cinnamomi 92.6g, Radix Paeoniae Alba 138.9g, Radix Saposhnikoviae 92.6g, Rhizoma Anemarrhenae 138.9g, Rhizoma Atractylodis Macrocephalae 92.6g, Herba Ephedrae 138.9g, Rhizoma Zingiberis 55.56g, Radix Aconiti Lateralis Preparata 92.6g, Radix Glycyrrhizae 55.56g, Pheretima 92.6g, more than ten the flavor Chinese medicines, except that the Radix Paeoniae Alba and ginger powder are broken into the fine powder, eight flavors such as all the other Rhizoma Atractylodis Macrocephalaes decoct with water secondary, decocted 2 hours for the first time, decocted collecting decoction 1 hour for the second time, leave standstill, filter, it is the clear paste of 1.25-1.30 that filtrate is concentrated into 50 ℃ of survey relative densities, adds the Radix Paeoniae Alba and Rhizoma Zingiberis fine powder, mixing, drying is ground into fine powder, incapsulates; Perhaps the fine powder that is ground into is granulated with 50-80% concentration ethanol or 8-20% concentration syrup, drying adds grain amount 0.5-1% magnesium stearate lubricant, and mixing incapsulates, and makes 1000, makes capsule, and specification is every capsules dress 0.4g.
Above-mentioned filtrate is concentrated into 50 ℃ when surveying relative densities and being 1.15-1.25, is spray dried to dry powder, adds the Radix Paeoniae Alba and Rhizoma Zingiberis fine powder, and mixing incapsulates medicated powder; Perhaps granulate with 50-80% concentration ethanol or 8-20% concentration syrup, drying, magnesium stearate lubricant or the Pulvis Talci of adding grain amount 0.5-1%, mixing incapsulates, and makes 1000, makes capsule, and specification is every capsules dress 0.4g.
Above-mentioned prescription ten flavor Chinese medicines, the Radix Paeoniae Alba, Rhizoma Zingiberis are extracted volatile oil, residue medicinal residues, medicinal liquid is standby, eight flavors such as all the other Ramulus Cinnamomi decoct with water secondary, adding for the first time 8 times of water gagings decocted 2 hours, add for the second time 6 times of water gagings and decocted 1 hour, decocting simultaneously for the second time, add above-mentioned medicinal residues and the medicinal liquid of carrying behind the volatile oil.Collecting decoction filters, and being condensed into 50 ℃ of survey relative densities is the fluid extract of 1.15-1.25, adds 3 times of amount 95% ethanol, left standstill 12 hours, and got supernatant, reclaim ethanol, being concentrated into 50 ℃ of survey relative densities is the thick paste of 1.20-1.30, adds cane sugar powder 410-415g, mixing, granulate drying, granulate, spray into volatile oil, mixing is made granule 463g, pack makes the sugar-containing type granule, and specification is every packed 10g; Perhaps add cane sugar powder 50-100g, dextrin or soluble starch 128-178g in thick paste, mixing is granulated, drying, and granulate sprays into volatile oil, makes granule 278g, packs, and makes to subtract sugared type granule, and specification is every packed 6g.
Above-mentioned prescription ten flavor Chinese medicines, the Radix Paeoniae Alba, Rhizoma Zingiberis are extracted volatile oil, residue medicinal residues, medicinal liquid is standby, eight flavors such as all the other Ramulus Cinnamomi decoct with water secondary, adding for the first time 8 times of water gagings decocted 2 hours, add for the second time 6 times of water gagings and decocted 1 hour, decocting simultaneously for the second time, add above-mentioned medicinal residues and the medicinal liquid of carrying behind the volatile oil.Collecting decoction filters, and being condensed into 50 ℃ of survey relative densities is the fluid extract of 1.15-1.25, add 3 times of amount 95% ethanol, be concentrated into 50 ℃ when surveying relative densities and being 1.15-1.25, be spray dried to dry powder, granulate drying, granulate with 50-80% concentration ethanol or 8-20% syrup, spray into volatile oil, mixing is made granule 93g, pack, make sugar-free granule, specification is every packed 2g.
Above-mentioned prescription ten flavor Chinese medicines, the Radix Paeoniae Alba, ginger powder are broken into fine powder, and eight flavors such as all the other Rhizoma Atractylodis Macrocephalaes decoct with water secondary, decocted 2 hours for the first time, decocted collecting decoction 1 hour for the second time, leave standstill, filter, it is the clear paste of 1.25-1.30 that filtrate is concentrated into 50 ℃ of survey relative densities, adds the Radix Paeoniae Alba and Rhizoma Zingiberis fine powder, mixing, granulate, be pressed into 1000, sugar coating; Perhaps in the time of 50 ℃, survey in the thick paste that relative density is 1.25-1.30 and add the Radix Paeoniae Alba and Rhizoma Zingiberis fine powder, mixing, drying, be ground into fine powder, granulate drying with the syrup of 50-80% ethanol or 8-10%, the magnesium stearate lubricant that adds grain amount 1%, mixing is pressed into 1000, sugar coating, make the agent of sugar-coat matrix, specification is the heavy 0.4g of every plain sheet.
Surveying relative density in the time of above-mentioned 50 ℃ is in the clear paste of 1.25-1.30, add the Radix Paeoniae Alba and Rhizoma Zingiberis fine powder, mixing, dry, be ground into fine powder, add calcium sulfate 24g, pregelatinized Starch 12g, microcrystalline Cellulose 2g, mixing is made granule with 10% syrup, drying, add the magnesium stearate of grain amount 0.5% and 1% Pulvis Talci, mixing is pressed into 1000 of the heavy slice, thin pieces of 0.4g, perhaps is pressed into 666 of the heavy slice, thin pieces of 0.6g, the bag film-coat, can obtain specification is the film-coat matrix agent of every heavy 0.41g or 0.61g.
The side separates:
Ramulus Cinnamomi: diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.Be used for anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.
The Radix Paeoniae Alba: the suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating is used for headache, and is dizzy, helps pain, stomachache, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat.
Radix Saposhnikoviae: inducing diaphoresis to dispel wind, win and wet, relieving convulsion.Be used for headache due to common cold, rubella pruritus, tetanus.
The Rhizoma Anemarrhenae: clearing away heat-fire, promote the production of body fluid and moisturize.Be used for fever caused by exogenous pathogenic factors, the hyperpyrexia excessive thirst, lung-heat type cough, osteopyrexia and fever, interior-heat is quenched one's thirst, the dryness of the intestine constipation.
The Rhizoma Atractylodis Macrocephalae: invigorating the spleen and benefiting QI, the dampness diuretic, hidroschesis, antiabortive.Be used for insufficiency of the spleen lack of appetite, abdominal distention diarrhea, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.
Herba Ephedrae: diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema.Be used for anemofrigid cold, uncomfortable in chest breathing with cough, edema due to wind pathogen edema, bronchial asthma.
Rhizoma Zingiberis: warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, the dampness expectorant.Be used for coldness and pain in the epigastrium, the vomiting diarrhea, the cold extremities faint pulse, phlegm retention is breathed with cough.
Radix Aconiti Lateralis Preparata: recuperating depleted YANG helps contrary, and it is supporing yang to mend fire, by wind-cold damp pathogen.Be used for the YANG-depletion collapse, the cold extremities faint pulse, sexual impotence, cold womb, trusted subordinate's cold type of pain, the deficiency and coldness leaf rushes down, YIN-cold edema, yang deficiency diseases caused by exogenous pathogenic factor, arthralgia due to cold-dampnes.
Radix Glycyrrhizae: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, cold relieving cough-relieving, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Be used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus is alleviated all poison of drug, strong.
Pheretima: the heat clearing away arresting convulsion, collateral dredging is relievingd asthma.Be used for unconsciousness due to high fever, infantile convulsion is twitched, arthralgia, numb limbs and tense tendons, hemiplegia, dyspnea and cough due to lung-heat, oliguria edema, hypertension.
This prescription is with Ramulus Cinnamomi, Radix Saposhnikoviae, Rhizoma Anemarrhenae expelling wind and cold, and the heat clearing away expelling pathogenic factors from muscles is a monarch drug; Being aided with Herba Ephedrae, Pheretima, Rhizoma Zingiberis, Radix Aconiti Lateralis Preparata, to mend fire supporing yang, and warming middle-JIAO wins wet, and collateral dredging dispels the wind and is ministerial drug; Be equipped with the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae and nutrition blood, analgesic therapy, dampness is adjuvant drug; With Radix Glycyrrhizae heat clearing away cold relieving, relieving spasm to stop pain is concocted all medicines, priming return through, messenger drug reaches disease institute, helping its medicine performance drug effect altogether is messenger drug.
Function with cure mainly
Dissipating cold, clearing heat and battalion's analgesic therapy.Be used for the muscle arthralgia, the heating that touch the part, but the conscious fear of cold of being afraid of cold, or touch not hot, but conscious heating, the whole body thermal image does not show.Rheumatism and rheumatoid arthritis, the person can use to see the above-mentioned symptom.
The rheumatismal clinical observation of this treatment by Chinese herbs intermingling cold and heat.
This Chinese medicine causes the pain animal model by Shenyang Pharmaceutical University by adjuvant arthritis animal model, chemical inflammatory model, chemical substance, carries out pharmacodynamic study, and this Chinese medicine of its conclusion has tangible antiinflammatory and analgesic activity.For further understanding the rheumatismal clinical effectiveness of this treatment by Chinese herbs, rheumatisant's 402 examples that differential diagnosis in tcm belonged to intermingling cold and heat in first hospital of Henan Province province-direct organizations, be divided into two groups in examining order at random with the ratio that is bordering on 3: 1, with the good ZHENGQINGFENGTONGNING of therapeutic effect is the contrast medicine, carried out clinical observation, inpatient's 165 examples wherein, outpatient's 237 examples, test group 298 examples, matched group 104 examples.
The case choice criteria:
Diagnose by tcm syndrome: limbs joint swells and ache, the heating of touching, but the warm fear of cold of happiness, or touch not hot, but conscious heating, light red tongue, yellow fur or white, wiry and frequent pulse is between age 18-65 year.
Efficacy evaluation:
With reference to treating rheumatismal efficacy evaluation branch in the new Chinese medicine clinical guidance principle:
Clinical recovery: symptom, sign disappear, and the lab testing leading indicator is recovered or be approaching normal;
Produce effects: symptom, sign disappear substantially, and laboratory is looked into leading indicator and obviously improved, decline degree 〉=50%;
Effectively: symptom, sign alleviate, and the lab testing leading indicator has improvement;
Invalid: symptom, sign and lab testing leading indicator do not have improvement.
Test structure such as following table:
Two groups of patient's clinical efficacies relatively
The gained data are carried out the Ridit analytic statistics, test group and matched group total effects be (P＜0.01) relatively, notable difference is arranged, this Chinese medicine of evidence has the function of dissipating cold, clearing heat and battalion's analgesic therapy really, be used for the treatment of the intermingling cold and heat rheumatism and have good result, and certain is better than contrasting the medicine ZHENGQINGFENGTONGNING PIAN in this respect.
Chinese medicine preparation prescription of the present invention is reasonable, and composition is accurate, and the pharmaceutical technology advanced person is fit to the demand of patient to different dosage form.
The specific embodiment
Embodiment one
Chinese medicine of a kind of dissipating cold, clearing heat and battalion's analgesic therapy and preparation method thereof is to be mixed with capsule, granule and tablet by Ramulus Cinnamomi, the Radix Paeoniae Alba, Radix Saposhnikoviae, the Rhizoma Anemarrhenae, the Rhizoma Atractylodis Macrocephalae, Herba Ephedrae, Rhizoma Zingiberis, Radix Aconiti Lateralis Preparata, Radix Glycyrrhizae and Pheretima and adjuvant.Prescription is Ramulus Cinnamomi 92.6g, Radix Paeoniae Alba 138.9g, Radix Saposhnikoviae 92.6g, Rhizoma Anemarrhenae 138.9g, Rhizoma Atractylodis Macrocephalae 92.6g, Herba Ephedrae 138.9g, Rhizoma Zingiberis 55.56g, Radix Aconiti Lateralis Preparata 92.6g, Radix Glycyrrhizae 55.56g, Pheretima 92.6g, more than ten the flavor Chinese medicines, except that the Radix Paeoniae Alba and ginger powder are broken into the fine powder, eight flavors such as all the other Rhizoma Atractylodis Macrocephalaes decoct with water secondary, decoct 2 hours for the first time, decoct 1 hour for the second time, collecting decoction, leave standstill, filter, it is the clear paste of 1.25-1.30 that filtrate is concentrated into 50 ℃ of survey relative densities, add the Radix Paeoniae Alba and Rhizoma Zingiberis fine powder, mixing, drying is ground into fine powder, incapsulate, make 1000, make capsule, specification is every capsules dress 0.4g.
Usage and dosage: oral, one time 6,3 times on the one.
Embodiment two
Embodiment two is that with embodiment one basic identical difference qinghuo reagent adds the Radix Paeoniae Alba and Rhizoma Zingiberis fine powder, mixing, and drying is ground into fine powder, granulates with 60% concentration ethanol, drying, the magnesium stearate of adding grain amount 1%, mixing incapsulates, and other is identical.
Embodiment three
Embodiment three and embodiment one are basic identical, and difference is that it is that filtrate is concentrated into 50 ℃ of survey relative densities at 1.20 o'clock, is spray dried to dry powder, adds the Radix Paeoniae Alba and Rhizoma Zingiberis fine powder, and mixing incapsulates medicated powder, and other is identical.
Embodiment four
Embodiment four and embodiment three are basic identical, and difference is that the medicated powder that will directly incapsulate granulates with 15% concentration syrup, drying, and the lubricant Pulvis Talci of adding grain amount 1%, mixing incapsulates, and other is identical.
Embodiment five
Get Ramulus Cinnamomi 92.6g, Radix Paeoniae Alba 138.9g, Radix Saposhnikoviae 92.6g, Rhizoma Anemarrhenae 138.9g, Rhizoma Atractylodis Macrocephalae 92.6g, Herba Ephedrae 138.9g, Rhizoma Zingiberis 55.56g, Radix Aconiti Lateralis Preparata 92.6g, Radix Glycyrrhizae 55.56g, Pheretima 92.6g, more than ten the flavor Chinese medicines, the Radix Paeoniae Alba, Rhizoma Zingiberis are extracted volatile oil, residue medicinal residues, medicinal liquid is standby, eight flavors such as all the other Ramulus Cinnamomi decoct with water secondary, add 8 times of water gagings for the first time and decoct 2 hours, add 6 times of water gagings for the second time and decoct 1 hour, decocting simultaneously for the second time, adding above-mentioned medicinal residues and the medicinal liquid of carrying behind the volatile oil.Collecting decoction filters, and being condensed into 50 ℃, to survey relative densities be 1.18 fluid extract, adds 3 times and measure 95% ethanol, left standstill 12 hours, and got supernatant, reclaim ethanol, being concentrated into 50 ℃, to survey relative densities be 1.25 thick paste, adds cane sugar powder 412g, mixing, granulate drying, granulate, spray into volatile oil, mixing is made granule 463g, pack makes the sugar-containing type granule, and specification is every packed 10g.
Usage and dosage: oral, each 10g, 3 times on the one.
Embodiment six
Embodiment six and embodiment five are basic identical, and it is 1.28 thick paste that difference is to get relative density, adds cane sugar powder 80g, dextrin 148g, mixing is granulated drying, granulate, spray into volatile oil, mixing is made granule 278g, pack, make and subtract sugared type granule, specification is every packed 6g, and other is identical.
Usage and dosage: oral, each 6g, 3 times on the one.
Embodiment seven
Embodiment seven and embodiment five are basic identical, and difference is to get fluid extract, add 3 times of amount 95% ethanol, being concentrated into 50 ℃ of survey relative densities is 1.20 o'clock, is spray dried to dry powder, granulates with 65% concentration ethanol, drying, granulate sprays into volatile oil, mixing, make granule 93g, pack makes sugar-free granule, specification is every packed 2g, and other is identical.
Usage and dosage: oral, each 2g, 3 times on the one.
Embodiment eight
Get Ramulus Cinnamomi 92.6g, Radix Paeoniae Alba 138.9g, Radix Saposhnikoviae 92.6g, Rhizoma Anemarrhenae 138.9g, Rhizoma Atractylodis Macrocephalae 92.6g, Herba Ephedrae 138.9g, Rhizoma Zingiberis 55.56g, Radix Aconiti Lateralis Preparata 92.6g, Radix Glycyrrhizae 55.56g, Pheretima 92.6g, more than ten the flavor Chinese medicines, getting the Radix Paeoniae Alba and ginger powder, to be broken into fine powder standby, eight flavors such as all the other Rhizoma Atractylodis Macrocephalaes decoct with water secondary, decocted 2 hours for the first time, decocted 1 hour for the second time, collecting decoction leaves standstill, and filters, it is 1.26 clear paste that filtrate is concentrated into 50 ℃ of survey relative densities, add the Radix Paeoniae Alba and Rhizoma Zingiberis fine powder, mixing is granulated, be pressed into 1000, sugar coating; Make the agent of sugar-coat matrix, specification is the heavy 0.4g of every plain sheet.
Usage and dosage: oral, each 6,3 times on the one.
Embodiment nine
Embodiment nine and embodiment eight are basic identical, and difference is qinghuo reagent, add the Radix Paeoniae Alba and Rhizoma Zingiberis fine powder, mixing, drying are ground into fine powder, and the syrup with 9% is granulated, dry, add the magnesium stearate lubricant of grain amount 1%, mixing is pressed into 1000, sugar coating, make the agent of sugar-coat matrix, specification is the heavy 0.4g of every plain sheet, and other is identical.
Embodiment ten
Embodiment ten and embodiment eight are basic identical, and difference is qinghuo reagent, add the Radix Paeoniae Alba and Rhizoma Zingiberis fine powder, mixing, drying is ground into fine powder, add calcium sulfate 24g, pregelatinized Starch 12g, microcrystalline Cellulose 2g, mixing is made granule with 10% syrup, drying adds the magnesium stearate of grain amount 0.5% and 1% Pulvis Talci, mixing, be pressed into 1000 of the heavy slice, thin pieces of 0.4g, the bag film-coat obtains the film-coat matrix agent of every heavy 0.41g of specification, and other is identical.
Usage and dosage: oral, each 6,3 times on the one.
Embodiment 11
Embodiment 11 and embodiment ten are basic identical, and difference is to be pressed into 666 of the heavy slice, thin pieces of 0.6g, the bag film-coat, and getting specification is the film-coat matrix agent of 0.61g, other is identical.
Usage and dosage: oral, each 4,3 times on the one.
Claims (8)
1, the Chinese medicine of a kind of dissipating cold, clearing heat and battalion's analgesic therapy is characterized in that being mixed with capsule, granule and tablet by Ramulus Cinnamomi, the Radix Paeoniae Alba, Radix Saposhnikoviae, the Rhizoma Anemarrhenae, the Rhizoma Atractylodis Macrocephalae, Herba Ephedrae, Rhizoma Zingiberis, Radix Aconiti Lateralis Preparata, Radix Glycyrrhizae, Pheretima and adjuvant; Prescription is Ramulus Cinnamomi 92.6g, Radix Paeoniae Alba 138.9g, Radix Saposhnikoviae 92.6g, Rhizoma Anemarrhenae 138.9g, Rhizoma Atractylodis Macrocephalae 92.6g, Herba Ephedrae 138.9g, Rhizoma Zingiberis 55.56g, Radix Aconiti Lateralis Preparata 92.6g, Radix Glycyrrhizae 55.56g, Pheretima 92.6g.
2, the Chinese medicine of a kind of dissipating cold, clearing heat according to claim 1 and battalion's analgesic therapy, it is characterized in that described adjuvant, comprise that syrup, cane sugar powder, dextrin, soluble starch, calcium sulfate, pregelatinated rush down powder, microcrystalline Cellulose, as the Pulvis Talci of the magnesium stearate of lubricant.
3, a kind of dissipating cold, clearing heat according to claim 1, Chinese medicinal preparation method with battalion's analgesic therapy, it is characterized in that getting Ramulus Cinnamomi 92.6g, Radix Paeoniae Alba 138.9g, Radix Saposhnikoviae 92.6g, Rhizoma Anemarrhenae 138.9g, Rhizoma Atractylodis Macrocephalae 92.6g, Herba Ephedrae 138.9g, Rhizoma Zingiberis 55.56g, Radix Aconiti Lateralis Preparata 92.6g, Radix Glycyrrhizae 55.56g, Pheretima 92.6g, more than ten the flavor Chinese medicines, except that the Radix Paeoniae Alba and ginger powder are broken into the fine powder, eight flavors such as all the other Rhizoma Atractylodis Macrocephalaes decoct with water secondary, decocted 2 hours for the first time, decocted collecting decoction 1 hour for the second time, leave standstill, filter, it is the clear paste of 1.25-1.30 that filtrate is concentrated into 50 ℃ of survey relative densities, adds the Radix Paeoniae Alba and Rhizoma Zingiberis fine powder, mixing, drying is ground into fine powder, incapsulates; Perhaps the fine powder that is ground into is granulated with 50-80% concentration ethanol or 8-20% concentration syrup, drying adds grain amount 1% magnesium stearate lubricant, and mixing incapsulates, and makes 1000, makes capsule, and specification is every capsules dress 0.4g.
4, the preparation method of Chinese medicine of a kind of dissipating cold, clearing heat according to claim 3 and battalion's analgesic therapy, it is characterized in that described filtrate is concentrated into 50 ℃ when surveying relative densities and being 1.15-1.25, be spray dried to dry powder, add the Radix Paeoniae Alba and Rhizoma Zingiberis fine powder, mixing incapsulates medicated powder; Perhaps granulate with 50-80% concentration ethanol or 8-20% concentration syrup, drying, the magnesium stearate lubricant or the Pulvis Talci of adding grain amount 1%, mixing incapsulates, and makes 1000, makes capsule, and specification is every capsules dress 0.4g.
5, the preparation method of Chinese medicine of a kind of dissipating cold, clearing heat according to claim 3 and battalion's analgesic therapy, it is characterized in that described ten flavor Chinese medicines, wherein the Radix Paeoniae Alba and Rhizoma Zingiberis are extracted volatile oil, residue medicinal residues, medicinal liquid is standby, eight flavors such as all the other Ramulus Cinnamomi decoct with water secondary, add 8 times of water gagings for the first time and decoct 2 hours, add 6 times of water gagings for the second time and decoct 1 hour, decocting simultaneously for the second time, adding above-mentioned medicinal residues and the medicinal liquid of carrying behind the volatile oil; Collecting decoction filters, and being condensed into 50 ℃ of survey relative densities is the fluid extract of 1.15-1.25, adds 3 times of amount 95% ethanol, left standstill 12 hours, and got supernatant, reclaim ethanol, being concentrated into 50 ℃ of survey relative densities is the thick paste of 1.20-1.30, adds cane sugar powder 410-415g, mixing, granulate drying, granulate, spray into volatile oil, mixing is made granule 463g, pack makes the sugar-containing type granule, and specification is every packed 10g; Perhaps add cane sugar powder 50-100g dextrin or soluble starch 128-178g in thick paste, mixing is granulated, drying, and granulate sprays into volatile oil, makes granule 278g, packs, and makes to subtract sugared type granule, and specification is every packed 6g.
6, the preparation method of Chinese medicine of a kind of dissipating cold, clearing heat according to claim 3 and battalion's analgesic therapy, it is characterized in that described prescription ten flavor Chinese medicines, wherein the Radix Paeoniae Alba and Rhizoma Zingiberis are extracted volatile oil, residue medicinal residues, medicinal liquid is standby, eight flavors such as all the other Ramulus Cinnamomi decoct with water secondary, add 8 times of water gagings for the first time and decoct 2 hours, add 6 times of water gagings for the second time and decoct 1 hour, decocting simultaneously for the second time, adding above-mentioned medicinal residues and the medicinal liquid of carrying behind the volatile oil; Collecting decoction filters, and being condensed into 50 ℃ of survey relative densities is the fluid extract of 1.15-1.25, add 3 times of amount 95% ethanol, be concentrated into 50 ℃ when surveying relative densities and being 1.15-1.25, be spray dried to dry powder, granulate drying, granulate with 50-80% concentration ethanol or 8-20% syrup, spray into volatile oil, mixing is made granule 93g, pack, make sugar-free granule, specification is every packed 2g.
7, the preparation method of Chinese medicine of a kind of dissipating cold, clearing heat according to claim 3 and battalion's analgesic therapy is characterized in that described prescription ten flavor Chinese medicines, and wherein the Radix Paeoniae Alba and ginger powder are broken into fine powder, eight flavors such as all the other Rhizoma Atractylodis Macrocephalaes decoct with water secondary, decoct 2 hours for the first time, decoct 1 hour for the second time, collecting decoction leaves standstill, and filters, it is the clear paste of 1.15-1.25 that filtrate is concentrated into 50 ℃ of survey relative densities, add the Radix Paeoniae Alba and Rhizoma Zingiberis fine powder, mixing is granulated, be pressed into 1000, sugar coating; Perhaps survey in the thick paste that relative densities are 1.25-1.30 and add the Radix Paeoniae Alba and Rhizoma Zingiberis fine powder obtaining 50 ℃, mixing, drying, be ground into fine powder, granulate drying with the syrup of 50-80% ethanol or 8-10%, the magnesium stearate lubricant that adds grain amount 1%, mixing is pressed into 1000, sugar coating, make the agent of sugar-coat matrix, specification is the heavy 0.4g of every plain sheet.
8, a kind of dissipating cold, clearing heat according to claim 3, preparation method of Chinese medicine with battalion's analgesic therapy, it is characterized in that described is the clear paste of 1.25-1.30 obtaining 50 ℃ of survey relative densities, add the Radix Paeoniae Alba and Rhizoma Zingiberis fine powder, mixing, dry, be ground into fine powder, add calcium sulfate 24g, pregelatinized Starch 12g, microcrystalline Cellulose 2g, mixing, make granule with 10% syrup, drying adds the magnesium stearate of grain amount 0.5% and 1% Pulvis Talci, mixing, be pressed into 1000 of the heavy slice, thin pieces of 0.4g, perhaps be pressed into 666 of the heavy slice, thin pieces of 0.6g, the bag film-coat, can obtain specification is the film-coat matrix agent of every heavy 0.41g or 0.61g.
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| CN103446302A (en) * | 2013-09-13 | 2013-12-18 | 李志玲 | Traditional Chinese medicine composition for treating neuropathic pain and preparation method thereof |
| CN104189412A (en) * | 2014-08-25 | 2014-12-10 | 河南科技大学第一附属医院 | Application paste for treating arthritis and preparation method thereof |
| CN105535886A (en) * | 2015-12-28 | 2016-05-04 | 杨玲林 | Drug for treating lumbocrural pain |
| CN107233540A (en) * | 2016-03-28 | 2017-10-10 | 石岳明 | A kind of Chinese medicine composition for treating rheumatoid arthritis |
| CN108740194A (en) * | 2018-06-04 | 2018-11-06 | 广西柳州俐多商贸有限责任公司 | A kind of potent warm the womb returns positive ginger tea with brown sugar and preparation method thereof |
| CN108939035A (en) * | 2018-10-11 | 2018-12-07 | 兰州大学 | It is a kind of for preventing and treating the Chinese medicine composition of Diet ephidrosis |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103446302A (en) * | 2013-09-13 | 2013-12-18 | 李志玲 | Traditional Chinese medicine composition for treating neuropathic pain and preparation method thereof |
| CN103446302B (en) * | 2013-09-13 | 2015-04-01 | 李志玲 | Traditional Chinese medicine composition for treating neuropathic pain and preparation method thereof |
| CN104189412A (en) * | 2014-08-25 | 2014-12-10 | 河南科技大学第一附属医院 | Application paste for treating arthritis and preparation method thereof |
| CN105535886A (en) * | 2015-12-28 | 2016-05-04 | 杨玲林 | Drug for treating lumbocrural pain |
| CN107233540A (en) * | 2016-03-28 | 2017-10-10 | 石岳明 | A kind of Chinese medicine composition for treating rheumatoid arthritis |
| CN108740194A (en) * | 2018-06-04 | 2018-11-06 | 广西柳州俐多商贸有限责任公司 | A kind of potent warm the womb returns positive ginger tea with brown sugar and preparation method thereof |
| CN108939035A (en) * | 2018-10-11 | 2018-12-07 | 兰州大学 | It is a kind of for preventing and treating the Chinese medicine composition of Diet ephidrosis |
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