CN101313838A - Ultra-optical spectrum imaging diagnostic device in vivo - Google Patents
Ultra-optical spectrum imaging diagnostic device in vivo Download PDFInfo
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- CN101313838A CN101313838A CNA2008100399548A CN200810039954A CN101313838A CN 101313838 A CN101313838 A CN 101313838A CN A2008100399548 A CNA2008100399548 A CN A2008100399548A CN 200810039954 A CN200810039954 A CN 200810039954A CN 101313838 A CN101313838 A CN 101313838A
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Abstract
The invention discloses an in vivo hyperspectral imaging diagnosis apparatus comprising an optical fiber, an endoscope, a condenser, an excitation light source, an incident lens, a dispersion unit, a CCD, a dispersion unit controller and a computer. The apparatus is characterized in that: the excitation light source, the condenser, the endoscope, the incident lens, the dispersion unit and the CCD are connected in turn to form a light path; the convergent excitation light source is connected to the endoscope through the optical fiber and irradiates living body tissues in vivo through a port of the endoscope, and reflected light is transmitted to the incident lens through the optical fiber and is imaged on the CCD after passing through the dispersion unit. A signal cable of the CCD is connected to the computer, and a control line of the computer is connected to the dispersion unit controller which is connected to the dispersion unit. The computer changes wavelength through the controlling the dispersion unit, and collects image data through the CCD to obtain the hyperspectral image data of the living body tissues in vivo. The in vivo hyperspectral imaging diagnosis apparatus which is applied to the detection and analysis of organs in vivo can realize the early diagnosis of some diseases.
Description
Technical field
The present invention relates to a kind of biological tissue check and analysis device.Specifically be a kind of at body Hyper spectral Imaging diagnostic apparatus.Be used for the clinical diagnose field.
Background technology
Medical diagnostic method commonly used at present such as doctor's inspection, radioscopy, CT, B ultrasonic, MRI, endoscope etc. all are based on the method for morphology diagnosis principle.These diagnostic methods mainly are to analyze from the form that pathological changes takes place, and can't definitely diagnose the degree of pathological changes, and as for the slight changes such as biochemistry that pathological changes produces, these diagnostic means can't detect especially.In addition,, have only when diseased region acquires a certain degree just can be detected, can't accomplish the early diagnosis of disease because these diagnostic methods are based on morphology methods.
Biology and medical development have experienced dissection stage biology (histology's stage) that relies on the outward appearance identification and microscopic cells stage biology of going deep into the cell level, at present to the more high-stage development of molecular biosciences medical science.The molecular biosciences medical research shows, the physiology of biological tissue cell or molecular level and pathological change can reflect the organism physiological molecule level that change caused of molecular regulation and the variation of allomeric function in itself.If can detect the unusual biochemistry variation that biological tissue takes place at body (in vivo), then not only can improve the level of clinical diagnosis and treatment disease, more can really reach the early diagnosis of disease; Also can be used for the toxic and side effects of medicine, qualitative assessment, route of administration and the pharmaceutical dosimetry of curative effect, instruct treatment of diseases.These all are directly connected to patient's treatment and health care, and population health level and people's living standard are significant for improving.
Summary of the invention
The objective of the invention is to overcome the deficiency of existing medical diagnostic apparatus, a kind of clinical diagnosis that is advantageously applied to is provided, particularly can be used in intravital at body Hyper spectral Imaging diagnostic apparatus, this diagnostic apparatus uses acousto-optic tunable wave filter (Acousto Optic Tunable Filter, AOTF) or liquid crystal tunable filter (Liquid Crystal Tunable Filter, LCTF) as the chromatic dispersion unit, once gather the information that promptly can obtain biological tissue image and spectrum two aspects simultaneously, handle through the Intelligent Recognition analysis software, can analyze detecting the position from form and biochemical two aspects, provide diagnostic result more accurately, for the early diagnosis of disease provides a kind of new method.
The object of the present invention is achieved like this:
A kind of at body Hyper spectral Imaging diagnostic apparatus, comprise optical fiber, endoscope, condenser lens, excitation source, incident lens, chromatic dispersion unit, CCD, chromatic dispersion cell controller and computer, characteristics are that excitation source, condenser lens, endoscope, incident lens, chromatic dispersion unit, CCD become light path to connect successively; After excitation source focuses on through condenser lens, use optical fiber to be connected to endoscope and shine in the body on the biological tissue by endoscope's light guide bundles port at last, the signal that is reflected by biological tissue is transferred to the incident lens through the imaging optical fiber bundle of endoscope, image on the CCD through behind the chromatic dispersion unit, CCD with image data acquiring in computer.
Circuit connects: the ccd output signal cable connects computer, and computer connects chromatic dispersion cell controller and excitation source, and the chromatic dispersion cell controller connects the chromatic dispersion unit; The data acquisition of computer and control assembly are connected on the excitation source on the one hand, the work of control excitation source; Be connected on the other hand on chromatic dispersion unit controls parts and the CCD, the chromatic dispersion unit is regulated in different wavelength, simultaneously with the image acquisition of CCD and note.
Image by same area biological tissue different wave length in the continuous acquisition body can obtain this regional hyperspectral image data, i.e. the image cube at last.This data cube had both comprised the view data of biological tissue, had also comprised its spectroscopic data.In conjunction with the data acquisition and processing (DAP) software that moves on the computer, the ultraphotic spectrum data of biological tissue in the body of gathering are carried out Intelligent Recognition and analysis, can carry out form and biochemical analysis to biological tissue simultaneously, realize the early diagnosis of disease.
Above-mentioned endoscope is common medical rigid endoscope, optical fibers scope or directly uses imaging fibre to replace; Described chromatic dispersion unit is elements such as AOTF, LCTF; Described excitation source is common laser light source or white light source.
The present invention uses the image of biological tissue different wave length in the chromatic dispersion unit acquisition volume, obtains its hyperspectral image data at last.Except can be on form detected zone being analyzed, can also analyze biological tissue from the spectrum angle, because spectral information can directly reflect physiology and the metabolic variation of biological tissue before genetic morphology changes, therefore when disease produces, can accomplish the early diagnosis of disease according to detected ANOMALOUS VARIATIONS.
Description of drawings
Fig. 1 is a structural representation of the present invention
The specific embodiment
Provide one of the present invention embodiment preferably according to Fig. 1 below, in order to architectural feature of the present invention to be described, technical performance and function point, rather than be used for limiting scope of the present invention.
Consult Fig. 1, excitation source 5, condenser lens 4, endoscope 3, incident lens 6, chromatic dispersion unit 7, CCD 8 become light path to connect successively in the present embodiment, the exciting light of excitation source 5 is through behind the condenser lens 4, be connected to endoscope 3 by optical fiber 2, the port of endoscope 3 is aimed at but the interior tested biological tissue 1 of direct contact, the optical signal that is reflected by biological tissue 1 spreads out of to incident lens 6 through the optical fiber that is connected with endoscope 3 pincers holes, pass through chromatic dispersion unit 7 beam split after, image at last on the CCD 8.Chromatic dispersion cell controller 9 is connected to the data acquisition and the control card of computer 10, controls according to the control signal of the computer 10 throwaway unit 7 of checking colors.CCD 8 signal cables are connected to the data acquisition and the control card of computer 10, finish the collection of view data.
In the present embodiment, endoscope 3 adopts the GES-300A fibergastroscope, and excitation source 5 is the argon laser source, and chromatic dispersion unit 7 uses AOTF.During instrument work, excitation source 5 is connected to endoscope 3 by optical fiber 2, shine at last on the interior biological tissue 1 of body, its reflected light spreads out of by optical fiber 2, arrive chromatic dispersion unit 7 through incident lens 6, computer 10 makes reflected light be in different wavelength by chromatic dispersion cell controller 9, and then the data collecting card of computer 10 is gathered the biological tissue image of the different wave length of CCD 8 outputs, promptly can obtain the hyperspectral image data of biological tissue 1 in the body.
The data acquisition and the analysis software that run on the computer 10 are mainly realized following function: instrument calibration, the data acquisition of biological tissue ultraphotic spectrum, real time imaging demonstration, hardware configuration and control, image data format conversion, Intelligent Recognition and analysis etc.
The present invention can obtain the hyperspectral image data of biological tissue in the body, not only can on form, detect it, can also analyze biological tissue from the biochemistry angle, compare with the ordinary optical detection means, the more diagnostic message of horn of plenty can be provided, therefore, the present invention be used for the detection and the analysis of intracorporeal organ, can realize the early diagnosis of some disease, have important application value.
Claims (4)
1, a kind of at body Hyper spectral Imaging diagnostic apparatus, comprise optical fiber (2), endoscope (3), condenser lens (4), excitation source (5), incident lens (6), chromatic dispersion unit (7), CCD (8), chromatic dispersion cell controller (9) and computer (10), it is characterized in that excitation source (5), condenser lens (4), endoscope (3), incident lens (6), chromatic dispersion unit (7), CCD (8) become light path to connect successively; CCD (8) output signal cable connects computer (10), and computer (10) connects chromatic dispersion cell controller (9) and excitation source (5), and chromatic dispersion cell controller (9) connects chromatic dispersion unit (7).
2, according to claim 1 at body Hyper spectral Imaging diagnostic apparatus, it is characterized in that described endoscope (3) is common medical rigid endoscope, optical fibers scope or directly uses imaging fibre to replace.
3, according to claim 1 at body Hyper spectral Imaging diagnostic apparatus, it is characterized in that described excitation source (5) is cold light LASER Light Source or common white radiant.
4, according to claim 1 at body Hyper spectral Imaging diagnostic apparatus, it is characterized in that described chromatic dispersion unit (7) is acousto-optic tunable wave filter (AOTF) or liquid crystal tunable filter (LCTF).
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100399548A CN101313838A (en) | 2008-07-01 | 2008-07-01 | Ultra-optical spectrum imaging diagnostic device in vivo |
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| CNA2008100399548A CN101313838A (en) | 2008-07-01 | 2008-07-01 | Ultra-optical spectrum imaging diagnostic device in vivo |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101785664A (en) * | 2010-03-30 | 2010-07-28 | 华东师范大学 | Head and face multi-dimensional diagnosis analyser |
| CN103263244A (en) * | 2013-05-27 | 2013-08-28 | 上海大学 | Endoscope device using single optical fiber to achieving imaging |
| CN103271714A (en) * | 2013-05-27 | 2013-09-04 | 上海大学 | Microcosmic fiber optic endoscope |
| CN106963459A (en) * | 2017-04-28 | 2017-07-21 | 山东大学 | A kind of bone marrow aspiration endoscopic imaging system and method |
| CN110248584A (en) * | 2017-02-01 | 2019-09-17 | 富士胶片株式会社 | Endoscopic system and its working method |
-
2008
- 2008-07-01 CN CNA2008100399548A patent/CN101313838A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101785664A (en) * | 2010-03-30 | 2010-07-28 | 华东师范大学 | Head and face multi-dimensional diagnosis analyser |
| CN103263244A (en) * | 2013-05-27 | 2013-08-28 | 上海大学 | Endoscope device using single optical fiber to achieving imaging |
| CN103271714A (en) * | 2013-05-27 | 2013-09-04 | 上海大学 | Microcosmic fiber optic endoscope |
| CN110248584A (en) * | 2017-02-01 | 2019-09-17 | 富士胶片株式会社 | Endoscopic system and its working method |
| CN110248584B (en) * | 2017-02-01 | 2022-02-18 | 富士胶片株式会社 | Endoscope system and method for operating same |
| US11490783B2 (en) | 2017-02-01 | 2022-11-08 | Fujifilm Corporation | Endoscope system and method of operating same |
| CN106963459A (en) * | 2017-04-28 | 2017-07-21 | 山东大学 | A kind of bone marrow aspiration endoscopic imaging system and method |
| CN106963459B (en) * | 2017-04-28 | 2019-05-24 | 山东大学 | A kind of bone marrow aspiration endoscopic imaging system and method |
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Open date: 20081203 |