CN101304723A - Denture adhesive compositions - Google Patents
Denture adhesive compositions Download PDFInfo
- Publication number
- CN101304723A CN101304723A CN200680041902.3A CN200680041902A CN101304723A CN 101304723 A CN101304723 A CN 101304723A CN 200680041902 A CN200680041902 A CN 200680041902A CN 101304723 A CN101304723 A CN 101304723A
- Authority
- CN
- China
- Prior art keywords
- compositions
- mixture
- salt
- goods
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Abstract
The present invention relates to denture adhesive compositions comprising a safe and effective adhesive amount of a denture adhesive component; a safe and effective amount of a component selected from the group consisting of a water insoluble thermoplastic component, a water insoluble liquid component, water-soluble thermoplastic component, water-soluble liquid component, and mixtures thereof; wherein the composition comprises a normalized dislodgement force of from about 1100 to about 12,000 grams per sq.cm. and/or a dislodgement force ratio from about 1.1 to about 10.
Description
Technical field
This invention relates to Denture adhesive compositions, and relate to Denture adhesive compositions specifically through improving, described compositions has about 0.11MPa (1100 gram/square centimeter) to the normalization tripping force of about 1.18MPa (12,000 gram/square centimeter) or about 1.1 to about 10 tripping force ratio.
Background of invention
Common detachable dental prostheses, dental lamina etc. are made up of the artificial tooth that is embedded on suitable dens supporter or the pedestal.Though artificial tooth and individual user fit traditionally, stickiness can reduce along with the time, and this reduction can cause slides or discomfort.Adhesive for denture is used for artificial tooth is temporarily sticked to oral surfaces, sticks on the oral mucosa specifically.When artificial tooth is placed the oral cavity, can in daystart, the adhesive for denture typical case be administered on artificial tooth or the oral surfaces, and in one day process, because saliva and mastication, binding agent is tending towards bioerosion and falls.
Over the years, people have carried out sizable effort and have researched and developed improved adhesive for denture product.Improving the binding agent retention and reducing the trial of under tooth plate, oozing out, and in the trial of avoiding using the back residual adhesive to tousle and being difficult to from oral cavity and artificial tooth, remove, used separately and used and synthesized and natural polymer and natural gum with different binding agents and other combination of materials.For example, known alkyl vinyl ether-maleic acid and salt thereof are used in retentivity are provided in the Denture adhesive compositions.Above-mentionedly openly comprise: on October 10th, 1961 announced authorizes people's such as Germann United States Patent (USP) 3,003,988; Nineteen ninety the United States Patent (USP) 4,980,391 of authorizing people such as Kumar announced of December 25 days; December in 1991 was announced on the 17th authorizes people's such as Holeva United States Patent (USP) 5,073,604; The United States Patent (USP) of authorizing Clarke 5,525,652 that on June 11st, 1996 announced; The United States Patent (USP) of announcing on August 23rd, 1,994 5,340,918 of authorizing people such as Kittrell; The United States Patent (USP) of announcing on November 3rd, 1,998 5,830,933 of authorizing people such as Synodis.
Except cohesive, wish that also reduction is exudative, or reduce the not aesthetic property that oozes out that consumer experienced.Because multiple factor causes adhesive for denture seepage under the tooth plate in the oral cavity, and oozes out, described factor comprises adhesive for denture on adhesive for denture viscosity is low, use is too much adhesive for denture, the tooth plate incorrect use etc.When oozing out in the oral cavity, described Denture adhesive compositions contacts with the oral cavity.Therefore, any negative taste that described Denture adhesive compositions is followed, negative mouthfeel or any other aesthetic property not, for consumer more obviously and make us unhappy.The source of above-mentioned negative sensation comprises the salt of adhesive for denture polymer self or adhesive for denture polymer, comprises and crosslinked those of zinc salt.The taste Consideration is important, because Denture adhesive compositions used in the oral cavity maximum 6 to 7 hours or more of a specified duration.In addition, if consumer has experienced the negative impression of oozing out, then they may stop using binding agent, perhaps may be tending towards using less binding agent next time.This can cause the artificial tooth retentivity to reduce, or the artificial tooth performance reduces.The reduction of this performance means the reduction of artificial tooth stability, artificial tooth retentivity, or food self is embedded in the increase under the artificial tooth.
According to the present invention, the Denture adhesive compositions of this paper will provide the adhesive for denture characteristic of these improvement, comprise the cleaning that the exudative and/or various oral environment of retentivity, stickiness, the easily property handled, the easily property used, the reduction of improvement improves down.
Summary of the invention
The present invention relates to a kind of Denture adhesive compositions, described compositions comprises the adhesive for denture component of safe and effective bonding amount and the water-msoluble ingredients of safety and effective dose, and described component is selected from the group of being made up of water-insoluble thermoplastic component, water-insoluble liquid component and their mixture; Wherein said compositions has about 0.11MPa (1100 gram/square centimeter) to the normalization tripping force of about 1.18MPa (12,000 gram/square centimeter) or about 1.1 to about 10 tripping force ratio.
Summary of drawings
Though this description by particularly pointing out and clearly claimed letter of authorization requirement of the present invention is drawn a conclusion, should believe by following explanation and can understand the present invention better in conjunction with the accompanying drawings, wherein:
Fig. 1 is the top view with concave shape Denture adhesive article embodiment of symmetrical size;
Fig. 2 is the top view with concave shape Denture adhesive article embodiment of asymmetric size.
Detailed Description Of The Invention
The below provides the detailed description of solvent of the present invention and optional components.
Definition
Abbreviation used herein " cm " is meant centimetre.Abbreviation used herein " mm " is meant millimeter.Abbreviation used herein " g " is meant gram.
Term used herein " artificial tooth " and/or " artificial tooth " are meant upper jaw artificial tooth or lower jaw artificial tooth, or both.
Term used herein " Denture adhesive article " and/or " goods " are meant and are designed for and profiled surface such as artificial tooth and gums or palate applying, suitable shape and adherent goods.The goods of this paper are essentially solid before use, and available basically hands picks up with integral type, and are placed on the artificial tooth.
Term used herein " flexible " or " flexible article " are meant that the thick goods for 0.67mm of sheet can twine 180 degree along the solid cylinder of diameter 1cm, but crack-free under visual observation.
Term used herein " safety and effective bonding amount " is meant to be enough to adhesion is provided and/or is enough to provide artificial tooth adherent amount to the oral cavity to the oral cavity, and described amount is nontoxic to user, or harmless to oral cavity tissue.
Term used herein " safety and effective dose " is meant in rational medical science/odontology determination range, the amount of reagent is enough high to be changed disease to be treated or actively changes the beneficial effect of looking for significantly (energetically), but described amount is enough low again to avoid serious adverse (reasonably effect/danger than).The safety of reagent and effective dose can along with the concrete disease of being treated, the concrete form in the patient's age for the treatment of and health, the order of severity of disease, the persistent period of treatment, the type of Synergistic treatment, used source and reagent so as to the concrete carrier used and change.
Term used herein " AVE/MA " is meant alkyl vinyl ether-maleic acid or copolymer-maleic anhydride.Term used herein " mixed polymerization salt " or " salt-mixture " are meant the salt of AVE/MA, wherein have at least two kinds of different cationes to be mixed with each other on same polymer or mix with other salt.
Term " free acid " used herein " or " FA " component be meant (any other monovalence carboxyl cation (for example COONa) COOH), and in the described polymer of unreacted carboxyl in the AVE/MA copolymer.Monovalent cation comprises IA family cation, such as sodium, potassium, hydrogen etc.In one embodiment, term " free acid " " be meant that unreacted carboxyl among the AVE/MA is (COOH), and sodium and potassium cationic.In another embodiment, term " free acid " " only be meant that unreacted carboxyl is (COOH) among the AVE/MA.
Term used herein " toxicology is acceptable " is used to describe the suitable material to the mankind and/or animals administer of its toxic characteristic.
Term used herein " non-water " is meant that described compositions does not comprise additional water, but can comprise the water that is contained in the another kind of component, as the component that is provided by manufacturer's commercialization.
Term used herein " water-insoluble " is meant when doing insoluble separate but can dispersive in various degree material of time spent with excessive water.In some embodiments, term " water-insoluble " is meant and can dissolves in water less than about material of 10%, 5%, 2% or 1%.
Term used herein " thermoplasticity " is meant fusing under heat effect, deliquescing and becomes more pliable and tougher, easier and extrude, more yielding, more can be shaped, easier mold pressing, easilier flow, easier processing and/or change the material of rheological behavior.In one embodiment, when with postcooling, described material solidifies usually, hardens and/or is returned to its original state substantially.
Term used herein " but bioerosion " is meant that because physics and/or chemical action, described compositions will corrode in time when doing the time spent with excessive water or saliva.Corrode the required time of described compositions and can be any time length from moment to five day.In one embodiment, erosion time is about 1 to about 3 days.Described compositions can eat away fully or substantially, yet final described compositions will lose its original form and/or integrity.For example, use in the oral cavity and used at least about after 24 hours, described compositions will not have enough product integrity, separate or will peel off from artificial tooth or oral surfaces with its original form being easy to.In one embodiment, described compositions bioerosion is so that described compositions uses about 24 hours in the oral cavity after, no compositions partly remains on artificial tooth or the oral cavity.In another embodiment, after from the oral cavity, taking out artificial tooth, remain on artificial tooth or the oral surfaces from some part or the remnants of compositions.Yet, by brushing, can clean these parts or remnants, but can't separate from artificial tooth easily from compositions with toothbrush.
The percentage ratio that this paper is used to describe alkyl vinyl ether-maleic acid or alkyl vinyl ether-copolymer-maleic anhydride cationic salts functional group is defined as the stoichiometry percentage ratio of all original carboxyls that act on the polymer.
Except as otherwise noted, all other percentage ratios used herein are all in the weight of described compositions.
Except as otherwise noted, all measurements of mentioning of this paper are all carried out under 25 ℃.
Except as otherwise noted, the percentage ratio of each composition of all that the present invention relates to, ratio and content is all based on the actual content of composition, and do not comprise as the commercially available prod solvent that can combine with these compositions, filler or other material.
The patent of all publications, patent application and announcement that the present invention mentions is all incorporated this paper into way of reference in full.Quoting of any document is not to its approval as the availability of the prior art of the present invention that is subjected to claims protection.
When any implication of the term in any implication of term in this written document record or definition and the document of incorporating this paper with way of reference into or define when conflicting, will be as the criterion with the implication or the definition of giving the term in this written document record.
Denture adhesive compositions
The present invention relates to be designed for and profiled surface such as artificial tooth and gums or palate applying, suitable shape and adherent Denture adhesive compositions.
In one embodiment, compositions described herein is selected from the group of being made up of following: goods, cream, paste, gel, liquid, wafer, band and their mixture.In another embodiment, described compositions can be extruded by container nozzle, as pipe, pump and/or syringe.In another embodiment, this paper compositions is goods.In one embodiment, the goods of this paper farthest reduce or avoid the problem of described goods too early adhesion during being applied to artificial tooth.In other words, for some Denture adhesive article of the prior art, before correctly being placed in goods on the artificial tooth target surface, goods can cause adhering to too early on one or more positions of artificial tooth with contacting unintentionally of artificial tooth.This has hindered the correct placement of goods.Adhesion too early also can cause goods contaminated or degraded before finally being placed on the artificial tooth.
In one embodiment, term used herein " aggressive tack " is meant that goods of the present invention show minimum and/or do not have cohesive or adhesiveness in dry state, until exerting pressure via user and activating.In one embodiment, this characteristic can make goods of the present invention store with any suitable pattern and distribute, and can not run into they self premature adhesion or adherent trouble, and need not separated demolding sheet, lining, pad etc.Simultaneously, in one embodiment, when exerting pressure activation with the suitable time in the position that suits, the dry state goods can show that enough cohesives are come and most of plastic surface (comprising the artificial tooth surface) formation bonding.This bonding is enough handled operation can bear artificial tooth by force, and can not lose caking property.Therefore, in one embodiment, dry state goods of the present invention only can adhere to when it is exerted pressure on the target artificial tooth surface, thereby farthest reduce or avoid this to be not intended to adherent problem during being placed on the artificial tooth surface.Thereby, in one embodiment, needn't before being administered on the artificial tooth, this paper goods be got wet or moistening, thereby a kind of method from goods to artificial tooth that simply and easily use is provided.
In one embodiment, term used herein " aggressive tack " is meant might be during being administered to goods of the present invention on the artificial tooth surface, described goods show minimum cohesive or adhesiveness and/or do not show any cohesive or adhesiveness, after described goods being warmed, exert pressure and activate via user at hands by user.
In another embodiment, this paper goods before being administered on the artificial tooth to the artificial tooth non-adhesiveness.
In another embodiment, term used herein " aggressive tack " is meant when this paper goods of dry and not moistening attitude are exerted pressure, and described goods can bond immediately via surface attachment and dry plastics (polymethyl methacrylate) and/or other artificial tooth substrate.In one embodiment, described dried product progressively bonds with dry artificial tooth substrate via surface attachment when finger is exerted pressure, described thus goods keep bonding under himself gravity, and do not using finger pressure this paper goods to be administered under the situation on the substrate, described goods can not keep the bonding to this dry matrices under himself gravity.In one embodiment, power or pressure can be produced by one or more fingers.In one embodiment, this power or finger pressure can be applied 1 to 10 second or more of a specified duration.In another embodiment, described goods can keep about 10 seconds to about 3 minutes or more of a specified duration the bonding of substrate, in another embodiment, can keep about 30 seconds to about 1 minute or more of a specified duration.
In one embodiment, the aggressive tack of described goods is about 0.0002,0.0009,0.009,0.09,0.98,9.81N/cm
2(0.025,0.1,1,10,100,1000 gram force/square centimeter) is to about 0.09,0.98,9.81,98.1,490.3,980.7N/cm
2(10,100,1000,10,000,50,000,100,000 gram force/square centimeter) and their any combination.
In one embodiment, the goods aggressive tack that can be reapposed is about 0.0002N/cm
2(0.025 gram force/square centimeter) is to about 0.003N/cm
2(0.30 gram force/square centimeter), and in another embodiment, be about 0.0002N/cm
2(0.025 gram force/square centimeter) is to about 0.002N/cm
2(0.25 gram force/square centimeter).
It is reported that when measuring, the room temperature modulus of any tacky adhesion is less than 0.3MPa (3 * 10 under the 1Hz frequency
6Dynes/cm).This discovery becomes adhesive standard, and is called as " Dahlquist cohesiveness standard ".(the Adhesion and Adhesives Technology of Alphonsus Pocius, the 2nd edition, 2002, CarlHanser Verlag, Munich).
In one embodiment of the invention, described goods have than about 0.3MPa (3 * 10
6Dyne/cm
2) ' Dahlquist cohesiveness standard ' bigger modulus.In another embodiment, described goods have greater than about 0.5 (5 * 10
6) storage shear modulus G ' (under the frequency of about 1Hz and about 25 ℃ temperature be that unit measure with MPa (dynes/cm)); In another embodiment greater than about 1 (1 * 10
7); In another embodiment greater than about 5 (5 * 10
7); And in another embodiment greater than about 8 (8 * 10
7).
In one embodiment, described compositions has about 0.1 (1 * 10
6), 0.3 (3 * 10
6), 0.5 (5 * 10
6), 1 (1 * 10
7), 5 (5 * 10
7) and 8 (8 * 10
7) to about 50 (5 * 10
8), 5 (5 * 10
7), 10 (1 * 10
8), 500 (5 * 10
9), 100 (1 * 10
9) and 1000 (1 * 10
10) storage shear modulus G ' (MPa (dynes/cm) is that unit measures under the frequency of about 1Hz and about 25 ℃ temperature) and/or their any combination.
In one embodiment, described compositions is goods, and have less than about 10 gram per centimeters, in another embodiment less than about 5 gram per centimeters, in another embodiment less than about 3 gram per centimeters, in another embodiment less than about 2 gram per centimeters, and be about 0.1 in another embodiment, 0.5,1 to about 2,3,5, the flexural stiffness of any combination of 10 gram per centimeters, described flexural stiffness can be according to method of testing ASTM D2923-95, (Philadelphia measures on #211-300 type Handle-O-Meter PA) deriving from Thwing-Albert Instrument Company.
In one embodiment, this paper compositions has about 0.11MPa (1100 gram/square centimeter) to about 1.18MPa (12,000 gram/square centimeter), about in another embodiment 0.13Mpa (1300 gram/square centimeter) is to about 0.98MPa (10,000 gram/square centimeter), about in another embodiment 0.12Mpa (1200 gram/square centimeter) is to about 0.49MPa (5000 gram/square centimeter), about in another embodiment 0.14MPa (1400 gram/square centimeter) is to about 0.49MPa (5000 gram/square centimeter), about in another embodiment 0.13Mpa (1300 gram/square centimeter) is to about 0.24MPa (2500 gram/square centimeter), and about in another embodiment 0.17Mpa (1750 gram/square centimeter) is to the normalization tripping force of about 0.24MPa (2500 gram/square centimeter).In another embodiment, described normalization tripping force is about 0.11MPa (1100 a gram/square centimeter), about 0.12MPa (1200 gram/square centimeter), about 0.13MPa (1300 gram/square centimeter), about 0.14MPa (1400 gram/square centimeter), about 0.15MPa (1500 gram/square centimeter), about 0.17MPa (1750 gram/square centimeter) is to about 1.18MPa (12,000 gram/square centimeter), about 0.98MPa (10,000 gram/square centimeter), about 0.74MPa (7500 gram/square centimeter), about 0.49MPa (5000 gram/square centimeter), about 0.25MPa (2500 gram/square centimeter), about 0.22MPa (2250 gram/square centimeter), and/or their any combination.In one embodiment, described tripping force ratio is about 1.1,1.2,1.3,1.4,1.5,1.6,1.7,1.8,1.9,2.0 to about 1.3,1.4,1.5,1.6,1.7,1.8,1.9,2.0,3,4,5,6,8,10 and/or their any combination.In one embodiment, described tripping force ratio is about 1.1 to about 10, about 1.1 to about 8, about 1.3 to about 4, and/or about 1.3 to about 2.5.
In one embodiment, the goods of this paper are essentially solid before use, and available basically hands picks up with integral type, and are placed on the artificial tooth.In addition, in one embodiment, described goods can be picked up by enough handss, are placed on then on the artificial tooth, and making does not almost have or do not have residue on the finger.In another embodiment, described goods comprise single layer.In another embodiment, described goods are layered product and/or composite.In one embodiment, described goods preforming and/or preform.In another embodiment, the goods of this paper can be distributed with unit dose packaging, multiple-unit container, pump, pouch, syringe or pipe by consumer, and can come molding via consumer; And in another embodiment, described goods can come molding via consumer, and can be at them stay a large amount of residues on hand.
In one embodiment, described Denture adhesive article is can be fully mobile, makes it to be used by pipe, and is picked up subsequently, is placed on the artificial tooth then.In one embodiment, described Denture adhesive article is can be fully mobile, makes it to be used by pipe, and is picked up subsequently, is placed on the artificial tooth then, and does not almost have or do not have residue on the finger.In another embodiment, described Denture adhesive article comprises solvent, and this makes and can be used by pipe by abundant mobile goods.Described solvent can be dissipated via evaporation, bio-absorbable, dispersion, dissolving etc. subsequently.In another embodiment, above-mentioned optional solvents also can be miscible with water-msoluble ingredients.In one embodiment, described Denture adhesive compositions is can be fully mobile, makes it to be used by pipe, and only has the amount of minimum level to ooze out under artificial tooth.In one embodiment, described Denture adhesive compositions has about 0%, 0.00001%, 0.001%, 5%, 10%, 15%, 20%, 25%, 30% to about 15%, 20%, 25%, 30%, 40%, 50% " normalization seepage discharge " and/or their any combination.In one embodiment, described Denture adhesive compositions has about 0,0.00001,0.001,0.01,0.1,0.2,0.3,0.4,0.5,0.6 to about 0.3,0.4,0.5,0.6,0.7 " oozing out ratio " and/or their any combination.
No matter goods with which kind of form distribute, and include but not limited to the instant goods of predetermined close and/or the goods that distributed by for example pipe, and described goods are solid all before use substantially, and available hands is picked up.Via following method, will be accredited as goods by the Denture adhesive article that pipe distributes.
Before beginning test, please read institute in steps.
1. (nozzle of 0.16 ") diameter is filled into product in the pipe with 0.41cm.
2. (on the 3.8cm * 3.8cm that is made by denture plastics (1.5 " * 1.5 ") square sheets), (1/8 ") located carefully to make nozzle remain on the about 0.32cm in artificial tooth sheet top the product of the long 2.5cm of bar (1 ") to be extruded into the artificial tooth sheet.When extruded product, please don't make nozzle touch the artificial tooth sheet.
3. (behind 1 ") product, (1/8 ") located, and uses scraper to cut described band along nozzle to make nozzle remain on the about 0.32cm in artificial tooth sheet top extruding about 2.5cm.When the cutting band, please don't make nozzle touch or smear the artificial tooth sheet.
4. use thumb and forefinger clip the middle part of band, and perpendicular to the artificial tooth sheet it are picked up.Please don't use finger on the artificial tooth sheet, to carry out wiping motion.
5. if it can integral type be picked up basically, then described compositions is goods.
Some Denture adhesive articles be predetermined close and/or instant.User can differentiate visually whether these article are Denture adhesive article, because they are generally the strips that is included in the packing.Yet, if these adhesive for dentures are not to be evident as goods, can differentiate by the following method whether these Denture adhesive articles are goods:
1. make compositions form about 0.67mm thick * about 8mm is wide * the long thin slice of about 44mm.
2. thin slice is placed on the artificial tooth sheet.
3. use finger to pick up thin slice.
4. if it can integral type be picked up basically, then described compositions is goods.
Basically integral type used herein be meant when with hands when pick up on the artificial tooth surface, about 75%, 80%, 85%, 90% to about 100%, 90%, 85%, 80%, 75%, 70% and/or the Denture adhesive compositions of their any combinations keep integral type.
Except above-mentioned method of testing, also can survey (as defined herein) according to oozing out method, differentiate via seepage discharge whether Denture adhesive article is goods.Except can picking up with hands and move with integral type basically, Denture adhesive article has also that to account for total composition about 0%, 3%, 5%, 10%, 15%, 20%, 25% to the normalization seepage discharge that accounts for total composition about 30%, 25%, 20%, 15%, 10%, 5%, 3% and/or their any combination and/or the described ratio that oozes out be about 0,00001,0.001,0.01,0.1,0.2,0.25,0.3 to about 0.1,0.2,0.25,0.3,0.4,0.5 and/or their any combination.
In one embodiment, the compositions of this paper comprises the natural source composition.
In one embodiment, the compositions of this paper comprises the homogeneous mixture of adhesive for denture component and water-insoluble thermoplastic component.
Described Denture adhesive article can have multiple shape and size, includes but not limited to symmetry or asymmetric concave.Fig. 1 shows symmetric concave shape Denture adhesive article 10.Fig. 2 shows asymmetrical concave shape Denture adhesive article 20, and Fig. 2 shows into the Denture adhesive article 20 of kidney type specifically.
The adhesive for denture component
The present invention comprises the adhesive for denture component of safe and effective bonding amount, described components contents is generally about 10% to about 90% by the weight of described goods, be about 15% to about 70% in another embodiment, be about 20% to about 70% in another embodiment, being about 25% to about 65% in another embodiment, is about 30% to about 65% in another embodiment.In one embodiment, compositions of the present invention comprises the weight at least 20% by described compositions, and at least 30% adhesive for denture component in another embodiment.
In one embodiment, the adhesive for denture component of this paper is a mucoadhesive, hydrophilic, water miscible, has swelling character under water function, and/or can form stickum when combining with moisture.In one embodiment, described adhesive for denture component is selected from the group of being made up of following material: natural gum, synthetic polymer natural gum, AVE/MA, the salt of AVE/MA, AVE/MA/IB, the salt of AVE/MA/IB, the copolymer of maleic acid or maleic anhydride and ethylene and salt thereof, maleic acid or maleic anhydride and cinnamic copolymer and salt thereof, the copolymer of maleic acid or maleic anhydride and isobutene. and salt thereof, polyacrylic acid and polyacrylate thereof, poly-itaconic acid and salt thereof, mucoadhesive polymers, the water solublity hydrophilic colloid, carbohydrate derivative, cellulose derivative, and their mixture.The example of above-mentioned substance comprise karaya, guar gum, gelatin, Algin, sodium alginate, Tragacanth, chitosan, acrylamide polymer, carbopol, polyvinyl alcohol, polyamine, poly quaternary ammonium compound, polyvinylpyrrolidone, cationic polyacrylamide polymer, AVE/MA, AVE/MA/IB, AVE/MA salt-mixture, AVE/MA/IB salt-mixture, polymeric acid, polysalt, polyol and their mixture.
In one embodiment, described adhesive for denture component be selected from the salt of the group of forming by following material: AVE/MA, the salt-mixture of AVE/MA, cellulose derivative (as methylcellulose, carboxymethyl cellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose, hydroxypropyl emthylcellulose and their mixture), polyethylene glycols, karaya, sodium alginate, chitosan, corn starch and their mixture.In another embodiment, described adhesive component be selected from the group of forming by following material: AVE/MA salt-mixture, cellulose derivative and their mixture.
In one embodiment, described adhesive for denture component is not thermoplastic and/or only comprises the small amounts of water soluble thermoplastic polymer, comprise about 0.01 to about 5% water-soluble thermoplastic polymer, as poly(ethylene oxide) class, hydroxypropyl cellulose, hydroxypropyl emthylcellulose; Polyethylene glycols; Comprise about 0.01 to about 1% water-soluble thermoplastic polymer in another embodiment, or be substantially free of water-soluble thermoplastic polymer.
Alkyl vinyl ether-maleic acid
In one embodiment of the invention, the described adhesive for denture component salt that is AVE/MA or AVE/MA.Alkyl vinyl ether-maleic acid comprises or is made of following constitutional repeating unit basically:
Wherein R represents alkyl, is C in one embodiment
1To C
5Alkyl, n are the integers greater than, the number of times that construction unit repeats in the representation polymer molecule.
In one embodiment, described adhesive component is AVE/MA and salt thereof, the salt-mixture of preferred AVE/MA, wherein said copolymer comprises the cationic salts functional group of cation, and described cation is selected from the group of being made up of following: IA family and 2A family cation, yttrium, titanium, zirconium, vanadium, chromium, manganese, ferrum, nickel, copper, zinc, boron, aluminum and their mixture in the periodic table of elements.In another embodiment, described adhesive component is the salt-mixture of AVE/MA, it comprises the cationic salts functional group of cation, described cation is selected from the group of being made up of following: strontium, zinc, ferrum, boron, aluminum, vanadium, chromium, manganese, nickel, copper, yttrium, titanium, magnesium, calcium, sodium and their mixture, and in another embodiment, described cation is selected from the group of being made up of following: strontium, zinc, ferrum, magnesium, calcium, sodium and their mixture.
In one embodiment, AVE/MA comprises cationic salts functional group, described salt comprises (accounting for all primary response carboxyls) about 5% to about 50%, about in another embodiment 10% to about zinc cation of 40%, about in another embodiment 10% to about 35%.These zinc cations can be selected from other following cation and mix: about 5% to about strontium cation of 65%, preferred about 10% to about 60%, about 0.001% to about 2.5%, preferred about 0.01% to about 2% ferrum, boron, aluminum, vanadium, chromium, manganese, nickel, copper, yttrium and/or titanium cation, and about 5% to about 65%, preferred about 15% to about 50% calcium and/or magnesium cation and/or sodium cation.
AVE/MA and salt thereof also are described in 12/17/91 United States Patent(USP) Nos. of announcing 5,073,604 of authorizing people such as Holeva; That announced on June 11st, 1996 authorizes people's such as Clarke 5,525,652; That announced on February 15th, 2000 authorizes people's such as Wong 6,025,411; That announced on July 19th, 1988 authorizes people's such as Shah 4,758,630; That announced on April 19th, 1994 awards people's such as Rajaiah 5,304,616; That announces June 13 nineteen ninety-five authorizes 5,424,058 of Rajaiah; 6/13/95 announce authorize people's such as Rajaiah 5,424,058; That announced on July 19th, 1988 authorizes people's such as Shah 4,758,630; That announced on November 3rd, 1998 authorizes people's such as Synodis 5,830,933; That announced on July 14th, 1936 authorizes people's such as Voss 2,047,398; That announced on October 10th, 1961 authorizes people's such as Germann 3,003,988; That announced on March 9th, 1999 authorizes people's such as Rajaiah 5,880,172; 5/4/99 announce authorize people's such as Prosise 5,900,470; 8/6/91 announce authorize people's such as Tazi 5,037,924; 1/21/92 announce authorize people such as Tazi 5,082,913 in; These patents are all incorporated this paper in full with way of reference.The salt of AVE/MA also is described in the Rajaiah that authorizes that announced on March 12nd, 2002, waits people's P﹠amp; The common unsettled U.S. Patent application 6,355,706 of G; JIUYUE in 2003 was announced on the 9th authorize people such as Rajaiah 6,617,374 in.
In one embodiment, in AVE/MA or the AVE/MA/IB salt content of free acid account for all initial carboxyls in the copolymer at least about 36%, be about 36% to about 60% in another embodiment, even be about 40% to about 55% in another embodiment.
In one embodiment, when measuring in preferred 1% weight/volume MEK (methyl ethyl ketone) solution under 25 ℃, the specific viscosity of initial copolymer acid or copolymer anhydride is about 1.2 to about 14.Can use other method and solvent to measure specific viscosity, as measuring in DMF (dimethyl formamide) solution of 1% weight/volume under 25 ℃ and in the 2-butanone solution of 1% weight/volume under 25 ℃.
Suitable AVE/MA copolymer can prepare via the method that prior art is known.Referring to for example US 2,782,182 and US 2,047,398.
The method for preparing AVE/MA polymer mixed salt is disclosed in further that December in 1991 announced on the 17th authorize people's such as Holeva United States Patent (USP) 5,073,604 and announced on February 16th, 1999 authorize people such as Liang 5,872,161 in.
Water-msoluble ingredients
Compositions of the present invention comprises the water-msoluble ingredients of safety and effective dose.In one embodiment, this components contents by the weight of described compositions count about 2%, 5%, 10%, 20%, 25%, 30%, 35% to about 45%, 50%, 60%, 70%, 90% and/or their any combination come the formation scope.In another embodiment, the content of described water-msoluble ingredients counts about 20% to about 70%, about 25% to about 60% by the weight of described compositions, or about 35% to about 60%.In another embodiment, described water-msoluble ingredients is water-insoluble, also is not swellability of water basically.
In one embodiment, described water-msoluble ingredients is water-insoluble liquid component, and it is selected from the group of being made up of following material: mineral oil, natural and artificial oil, fat, siloxanes, silicone derivative, polydimethylsiloxane, organic siliconresin, hydrocarbon, hydrocarbon derivative, quintessence oil, vegetable oil, polybutene, caprylic/capric triglyceride, corn, Semen sojae atricolor, Semen Gossypii, Semen Ricini, Petiolus Trachycarpi oil, Oleum Cocois, animal oil, fish oil, oleic acid and their mixture.In another embodiment, described water-msoluble ingredients is a PDMS natural gum, or PDMS natural gum and the mixture (referring to United States Patent (USP) 6,074,654) that removes the MQ resin that obtains as the volatility isoparaffin of desolvating.
In one embodiment, described water-msoluble ingredients is the water-insoluble thermoplastic component, and it is selected from the group of being made up of following material: rubber, elastomer, plastomer, native paraffin, synthetic wax, polrvinyl chloride, nylon, fluorocarbon, polyurethane prepolymer, polyethylene, polystyrene, polypropylene, celluosic resin, acrylic resin, vaseline and their mixture.In another embodiment, described water-insoluble thermoplastic component is selected from the group of being made up of following: native paraffin, synthetic wax, vaseline, polyethylene and their mixture.In another embodiment, described water-insoluble thermoplastic component is selected from the group of being made up of following: polyethylene, vaseline, paraffin, microwax, polypropylene, polystyrene and their mixture.In another embodiment, it is selected from the group of being made up of following material: polyethylene, microwax and their mixture.
In one embodiment, described water-insoluble thermoplastic component comprises elastomer, as ethylene-vinyl-acrylic rubber, ethylene-propylene rubber, styrene-ethylene-ethylene-vinyl-propylene-styrene rubber and their combination; And these can be chosen wantonly further and make up with wax.
In one embodiment, the osmotic value that has of the compositions of this paper is about 25 to about 350; Be about 27 to about 250 in another embodiment; Being about 30 to about 150 in another embodiment, is 40 to about 150 in another embodiment, is about 50 to about 80 in another embodiment, is about 60 to about 80 water-insoluble thermoplastic component in another embodiment.When adopting ASTM D1321 method to measure, described osmotic value is about 25 to about 250.When adopting ASTM D937 method to measure, described osmotic value is about 25 to about 350, and these two kinds of methods all are existing methods known in the art.Though ASTM D937 and ASTMD1321 are respectively applied for the osmotic value of measuring vaseline or pertroleum wax usually, but these methods also can be used for measuring derived from the wax of oil with by the osmotic value of other type water-insoluble thermoplastic component of suitable modification, these other components need be in fusion under the higher temperature, and this will be conspicuous to those skilled in the art.
In the process that obtains above-mentioned osmotic value, the water-insoluble thermoplastic component that is positioned at outside these osmotic values can become phase-splitting to mix with the another kind that changes described thermoplastic component osmotic value.Therefore, described water-insoluble thermoplastic component can be single component or mixture of ingredients.For example, (Crompton, Sonneborn) osmotic value of Zhi Zaoing is that about 15 to about 20 Multiwax W 180 can mix with vaseline (with 1: 1 ratio), so that osmotic value is risen to more than 25 by Witco.
In one embodiment, described water-insoluble thermoplastic component is natural or synthetic wax.These waxes comprise native paraffin, as animal wax, vegetable wax, mineral wax.Animal wax comprises Cera Flava, lanoline, shellac wax, white beeswax etc.Vegetable wax comprises Brazil wax, candelilla wax, bayberry, Caulis Sacchari sinensis etc., and mineral wax comprises fossil waxes or ceresine (paraffin, ceresin, montan wax) and pertroleum wax, as paraffin, crystallite etc.In one embodiment, the wax of this paper is native paraffin, is selected from the group of being made up of following: Cera Flava, candelilla wax, candle wax, Brazil wax, paraffin, microwax, Fischer-Tropsch wax and their mixture.
In another embodiment, described wax is by Crompton, the microwax that Sonneborn (Witco) makes, and with trade mark MutiwaxW-835 name and sale.This wax have scope be about 73.9 ℃ to about 79.4 ℃ fusing point (ASTM D127), under 25 ℃, has about 60 to about 80 osmotic value (ASTM D1321), under 98.9 ℃, has about 75 to about 90 kinetic viscosity (ASTM D2161), have minimum about 246 ℃ flash-point COC (ASTM D92), and have about 77 ℃ set point (ASTM D938).
In one embodiment, can be used for paraffin of the present invention and have about 65 ℃ to about 80 ℃ usually, about in another embodiment 70 ℃ to about 75 ℃ melting range.Can be used for microwax of the present invention can have about 65 ℃ to about 90 ℃ fusing point, can have in another embodiment about 80 ℃ to about 90 ℃ fusing point.Can be used for Cera Flava of the present invention can have about 62 ℃ to about 65 ℃ fusing point, have 242 ℃ flash-point simultaneously.Can be used for candelilla wax of the present invention can have about 68 ℃ to about 72 ℃ fusing point.Can be used for Carlow of the present invention crust wax can have about 83 ℃ to about 86 ℃ fusing point.Can be used for Fischer-Tropsch wax of the present invention can have about 95 ℃ to about 120 ℃ fusing point.Also can obtain to have Cera Flava, candelilla wax, Carlow crust wax with the artificial grade of the Cera Flava similarity of natural grade.
In another embodiment, described water-insoluble thermoplastic component is a polyethylene, as A-C 1702 and the A-C 6702 that is made by Honeywell, adopts ASTM D1321 method, and it has 98.5 and 90.0 osmotic value respectively.
In one embodiment, if described compositions comprises the poly(ethylene oxide) class, then or described water-msoluble ingredients be thermoplastic, perhaps described goods do not comprise fibrous web or paper laminate.
In one embodiment, the compositions of this paper is substantially free of and pure blended Mel.In another embodiment, described goods are substantially free of the vinylite that is dissolved in the ethanol.
Other optional member
Plasticizer
The present composition also can be chosen the acceptable plasticizer of one or more toxicitys that comprises safety and effective dose wantonly.In one embodiment, the content range of described plasticizer counts about 0.0% to about 40% by the weight of described compositions, being about 0.01% to about 40% in one embodiment, is about 1% to about 10% in another embodiment, is about 2% to about 5% in another embodiment.In another embodiment, described Denture adhesive compositions does not comprise plasticizer.
The plasticizer that the present invention suits includes but not limited to polyol (for example sorbitol); Glycerol; Propylene glycol; Acetylated monoglycerides; Hydrogenated starch hydrolysates; Corn syrup; And their derivant; Xylitol; The monoesters of glycerol and fatty acid; Glycerol triacetate; Glycerine 1,3-diacetate; And monoacetin; Dimethyl phthalate; Diethyl phthalate; Dioctyl phthalate; Diethylene glycol; 2,2'-ethylenedioxybis(ethanol).; Tricresyl phosphate; Dimethyl sebacate; Ethyl glycolate; Phthalic acid (ethyl ester) (glycolic ethyl ester) ester; N-ethyl orthotoluene sulfonamide and N-ethyl para toluene sulfonamide; Phthalic acid derivatives; glyceryl triacetate; citric acid derivant; phosphoric acid derivatives; ethylene glycol; ethylene glycol derivative; paraffin wax; fatty acid pentaerythritol ester; stearic acic derivative; glyceryl monostearate; polyethylene glycols; butyl phthalyl butyl glycolate; butyl phthalyl butyl glycolate; dimethyl phthalate; dibutyl phthalate; glycerol triacetate; triethyl citrate; acetyl triethyl citrate; acetyl tributyl citrate; triphenyl phosphate; diethylene glycol; Trivent OCG; tricaprin; two caprylic/capric propylene glycol esters; and/or their combination.
In another embodiment, described plasticizer is water-insoluble.
In one embodiment, because the effect of plasticizer components, described Denture adhesive compositions is being extruded Shi Buhui curing and hardening by thermoplastic.In another embodiment, described plasticizer components can not make water-msoluble ingredients or Denture adhesive compositions solidify.In another embodiment, described water-insoluble thermoplastic component can not solidify and hardening.
Alternatively, in one embodiment, described Denture adhesive compositions is substantially free of plasticizer.In one embodiment, described Denture adhesive compositions is substantially free of polyethyl methacrylate; glycerol triacetate; phthalic acid derivatives; glyceryl triacetate; citric acid derivant; phosphoric acid derivatives; ethylene glycol; ethylene glycol derivative; paraffin; fatty acid pentaerythritol ester; stearic acic derivative; glyceryl monostearate; polyethylene glycols; butyl phthalyl butyl glycolate; butyl phthalyl butyl glycolate; dimethyl phthalate; dibutyl phthalate; glycerol triacetate; triethyl citrate; acetyl triethyl citrate; acetyl tributyl citrate; triphenyl phosphate; diethylene glycol; Trivent OCG; tricaprin; two caprylic/capric propylene glycol esters and/or their combination.
Gellant
The present composition also can be chosen the acceptable gellant of one or more toxicitys that comprises safety and effective dose wantonly.In one embodiment, the content range of described gellant counts about 0.01% to about 40% by the weight of described compositions, is about 1% to about 10% in another embodiment, is about 2% to about 5% in another embodiment.
The gellant that the present invention suits includes but not limited to the polyvinylpyrrolidone/eicosylene copolymer available from ISP with trade name Ganex V-220F; With the melissyl polyvinylpyrrolidone of trade name Ganex WP-660 available from ISP; The polyamide gellant comprises all Sylvaclear, Sylvacote, Sylvagel, Uniclear available from ArizonaChemical; Comprise Sylvaclear Lightwax; Sylvaclear PA 20; Sylvaclear PA 30; Sylvaclear PA 50; Sylvacote 2228; Sylvacote 2228E; Sylvagel5000; Sylvagel 6000; Uniclear 100; Uniclear 100VG; Uniclear80; Uniclear 80V; And their mixture.
Flavoring agent, aromatic, sensory agent
Compositions of the present invention also can comprise one or more components, and these components provide local flavor, fragrance and/or realizable beneficial effect (heating agent or coolant).Suitable component comprises menthol, wintergreen oil, Oleum menthae, Oleum Menthae Rotundifoliae, folic alcohol, clove bud oil, the anethole, methyl salicylate, cineole, Cortex cinnamomi japonici (Ramulus Cinnamomi), acetic acid 1-8 menthyl ester, Salvia japonica Thunb., acetaminol, parsley oil, frambinone, α-Zi Luolantong, the fragrant flower Herba Menthae, Fructus Citri Limoniae, orange, 1-ethoxy-2-hydroxy-4-propenyl benzene, Cortex Cinnamomi, vanillin, thymol, linalool, the cinnamic aldehyde glycerine acetal that is called as CGA, and their mixture, and coolant.Coolant can be any various material.Comprise that these materials in the present invention are amide, menthol, ketal, glycol and their mixture.In one embodiment, coolant in the present composition is selected from the group of being made up of following: to alkylamino formyl reagent in the Meng, as the N-ethyl of commodity by name " WS-3 "-to alkane-3-amide in the Meng, the N of commodity " WS-23 " by name, 2,3-trimethyl-2-isopropyl butyramide and their mixture.The 3-1-menthoxypropane-1 that is called TK-10 that preferred in addition coolant is selected from menthol, is produced by Takasago, 2-glycol, the menthone glycerine acetal of producing by Haarmann and Reimer that is called MGA and by being called that Haarmann and Reimer produce
Menthyl lactate.Term menthol used herein and menthyl comprise dextrorotation and the laevoisomer and their racemic mixture of these chemical compounds.TK-10 is described in 7/10/84 United States Patent (USP) of announcing 4,459,425 of authorizing people such as Amano.WS-3 and other reagent are described in the United States Patent (USP) of announcing on January 23rd, 1,979 4,136,163 of authorizing people such as Watson.The content of these reagent counts about 0% to about 40% by the weight of described compositions, is about 0.05 to about 5% in another embodiment, is about 0.1 to about 2% in another embodiment.
Other optional member
Described Denture adhesive compositions also can comprise one or more therapeutic active substances that is suitable for topical.The therapeutic content of active substance counts about 0% to about 70% by the weight of described compositions, and is about 1% to about 20% in one embodiment.The therapeutic active substance comprises antimicrobial, as iodine, triclosan, peroxide, sulfonamide, bis-biguanide or phenol; Antibiotic is as tetracycline, neomycin, kanamycin, metronidazole, hexadecylpyridinium chloride, domiphen bromide or clindamycin; Antiinflammatory is as aspirin, acetaminophen, naproxen and salt thereof, ibuprofen, ketorolac, flurbiprofen, indometacin, acetaminol or hydrocortisone; Dentin desensitizer is as potassium nitrate, strontium chloride or sodium fluoride; Fluoride is as sodium fluoride, stannous fluoride, MFP; Anesthetis is as lignocaine or benzocaine; Antifungal, as be used for the treatment of those of Candida albicans; The aromatization thing is as Camphora, Eucalyptus oil and aldehyde derivatives, as benzaldehyde; Insulin; Steroid; Derive from the medicine of woody plant and other plant; And sodium bicarbonate.Generally acknowledge that in some form of therapy for obtaining optimum efficiency, it may be effective using these combination of agents in identical delivery system.Therefore, for example, antimicrobial and antiinflammatory can be mixed in the single delivery system so that the combination effect to be provided.
Other suitable composition comprises coloring agent, antiseptic (as methyl parahydroxybenzoate and propyl p-hydroxybenzoate), thickening agent such as silicon dioxide and polyethylene glycols.The content of coloring agent, antiseptic and thickening agent counts about 0% to about 20% by the weight of described compositions, is about 0.1% to about 10% in another embodiment.
In addition, described compositions also can comprise one or more solvents.These optional solvent easily and water-msoluble ingredients is miscible and/or can dissipate on the spot.In one embodiment, these solvents can dissipate on the spot via evaporation, dissolving, dispersion, bio-absorbable or any other suitable way.In another embodiment, these solvents can dissipate on the spot to stay Denture adhesive compositions.Above-mentioned solvent can comprise that 20 ℃ of following viscosity are at 1E-5,0.0001,0.001,0.005Pa.s (0.01,0.1,1, the 5 centipoise) material to 0.005,0.01,0.1, in 1Pa.s (5,10,100,1000 centipoise) and any combination range of this tittle.In one embodiment, these solvents can be siloxanes, hydrocarbon, Fancol ID, 2-Methylpentadecane, Isoeicosane and/or polyisobutylene.The The suitable solvent grade comprises Permethyl series (by Prespers Inc., New Jersey sells), as Permethyl 97A, 99A, 101A, 102A and their mixture.
The preparation of compositions method
In one embodiment, described compositions is the goods that can use according to the present invention, and can by this area for example the conventional method of thin film fabrication industry make, as mold, coating, press polish, extrude.In one embodiment, with the independent component melts in the described goods, blend in agitator tank then is until obtaining uniform mixture.Subsequently, can be with fused mixture in suitable substrate top casting to acceptable thickness.The embodiment of above-mentioned substrate comprises Mylar, the stainless steel band (if desired, it can finally enter drier section) that moves continuously, separate paper etc.Then goods are cooled off.Then if desired, with product dried, as dry in the forced ventilation baking oven.The temperature of dry air and the length of drying time depend on the character of solvent for use, generally acknowledge as this area.In general, baking temperature comprises between about 25 ℃ to 140 ℃, is about 60 ℃ to 90 ℃ temperature in another embodiment, continues about 20 minutes to about 60 minutes, about in another embodiment 30 to about 40 minutes.Then goods are cut into the suitable shape with suitable size, pile up subsequently and/or subsequently the packing.
In one embodiment, after processing, then described goods are die-cut to suitable shape.These shapes help described goods are administered on the artificial tooth.
Specifically, in one embodiment, following processing goods of the present invention: 1. melt the wax component; 2. AVE/MA salt is mixed with any other adhesive component; 3. binder combination is joined in the wax fused mass; 4. stir to obtain uniform mixture; 5. uniform mixture is poured in the mould or suitable surface on; 6. cool off described mixture, until its curing; 7. from substrate or mould, take out, or be cut into suitable shape.
Another conventional film build method known in the art is to extrude.The method is feasible to thin film, but wherein film forming component comprises multiple extruded material.The mechanical detail of extrusion method as used concrete equipment, the shape of extruding power, aperture and/or punch die and temperature, is considered to be in the technical scope of this area, and can changes in known manner, to obtain the physical characteristic of goods described herein.
In one embodiment, the thickness of this paper goods usually between about 0.1mm between about 2.5mm, in another embodiment for about 0.4mm is thick to about 1.5mm, be that extremely about 1mm is thick for about 0.5mm in another embodiment.According to user or the desired buffer index of wearer, described goods can be thicker or thinner.
In one embodiment, it is heterogenetic that the compositions of this paper can be chosen wantonly, or has visually different phase.In another embodiment, this paper goods can be chosen wantonly and have the liner of peeling off.In another embodiment, cream, paste, liquid and/or the gel of described compositions for making by known method.These comprise described adhesive for denture component are joined in described liquid and/or the thermoplastic component, and heating mixes, until forming uniform product.
Compositions is used
Usually the present composition is administered on the artificial tooth, subsequently artificial tooth is fixed in the oral cavity.In one embodiment, before applying said compositions with the artificial tooth drying.In one embodiment, need not before being administered on the artificial tooth with compositions and/or artificial tooth moistening, so that compositions adheres on the artificial tooth.Described compositions can be applied to any suitable location on the artificial tooth.In one embodiment, the artificial tooth wearer wore described compositions about 1 hour to about 3 days usually, was about 6 hours to about 24 hours in another embodiment.After the use, artificial tooth is taken out from the oral cavity, and shampoo gently, clean any residual compositions from artificial tooth by for example water and brush.
Following examples have further described with illustration the embodiment in the protection domain of the present invention.Given embodiment is used to illustrate, and can not regard limitation of the present invention as.Under the situation that does not deviate from the spirit and scope of the present invention, a lot of changes of these embodiment are possible.
Embodiment
Example I
| A | B | C | D | E | F | G | H | |
| Gram | Gram | Gram | Gram | Gram | Gram | Gram | Gram | |
| Ca/Zn AVE/MA salt | 33.00 | 33.00 | 33.00 | 53.00 | 33.00 | 28 | 24.5 | |
| CMC | 20.00 | 20.00 | 20.00 | 53.00 | 25.00 | 15 | 28.5 | |
| AVE/MA acid S-97 | 1.00 | |||||||
| Microwax 1W-835 | 46.92 | 47.00 | 47.00 | 47.00 | 47.00 | 42.00 | 45.52 | 46.92 |
| Flavoring agent | 0.50 | 0.4 | ||||||
| Glucide | 00.08 | 0.16 | 0.08 | 0.08 | ||||
| Coloring agent | 0.10 | |||||||
| Silicon dioxide | 1 | |||||||
| |
10 |
1(Crompton Sonneborn) makes Multiwax W 835 by Witco.Multiwax W 835 also can be substituted by polyethylene A-C 1702 or polyethylene A-C 6702.
With microwax W-835 (or polyethylene AC 1702 or A-C 6702) fusion, and with other composition and its blend.Then by any suitable method, for example extrude or roll off becomes to have the thin slice of suitable depth such as 0.25mm, 0.45mm, 0.50mm, 0.67mm, 0.73mm or 1.0mm, mixture is laminated.Then described thin slice is cut into the shape that is suitable for being administered on the artificial tooth.
In example I, all or part Ca/Zn AVE/MA salt can be substituted by Mg/Zn/NaAVE/MA salt and/or Ca/Na AVE/MA salt; All or part CMC can be substituted by carrageenin and/or suitable cellulose derivative; All or part microwax W-835 can be substituted by polyethylene A-C 1702 (deriving from Honeywell) and/or polyethylene A-C 6702 (deriving from Honeywell); And/or the amount of every kind of composition also can increase or reduce maximum about 50%.Before making goods, above-mentioned each embodiment blend each other; And/or collaborative each other the use, to form multi-layer product.
Example II
| A | B | C | D | E | F | |
| Gram | Gram | Gram | Gram | Gram | Gram | |
| Ca/Zn AVE/MA salt | 33.00 | 33.00 | 33.00 | 53.00 | 20.00 | |
| CMC | 20.00 | 20.00 | 20.00 | 53.00 | 33.00 | |
| Mineral oil | 17.96 | 11.98 | 5.99 | 17.96 | 11.98 | 5.99 |
| Microwax 2W-835 | 11.73 | 23.46 | 35.19 | 11.75 | 23.50 | 35.25 |
| Flavoring agent | 0.5 | |||||
| Glucide | 0.02 | 0.04 | 0.06 | 0.08 | ||
| Coloring agent | 0.10 | |||||
| Silicon dioxide | 0.86 | 0.57 | 0.29 | 0.86 | 0.57 | 0.29 |
| Vaseline | 16.43 | 10.96 | 5.48 | 16.43 | 10.96 | 5.48 |
2(Crompton Sonneborn) makes Multiwax W 835 by Witco.Multiwax W 835 also can be substituted by polyethylene A-C 1702 or polyethylene A-C 6702.
In example II,, and make other composition and its blend with microwax W-835 (or polyethylene AC 1702 or A-C6702) and vaseline fusion.All or part Ca/ZnAVE/MA salt can be substituted by Mg/Zn/Na AVE/MA salt and/or Ca/Na AVE/MA salt; All or part CMC can be substituted by carrageenin and/or suitable cellulose derivative; All or part microwax W-835 can be substituted by polyethylene A-C 1702 (deriving from Honeywell) and/or polyethylene A-C 6702 (deriving from Honeywell); And/or the amount of every kind of composition also can increase or reduce maximum about 50%.Above-mentioned each embodiment blend each other.
EXAMPLE III
| A | B | C | D | E * | |
| ％ | ％ | ％ | ％ | ％ | |
| Ca/Zn AVE/MA salt | 33 | 33 | 33 | 33 | 33 |
| |
20 | 20 | 20 | 20 | 20 |
| Silicon dioxide | 1.03 | 0.97 | 0.86 | 1.08 | 1.14 |
| Mineral oil | 21.56 | 20.36 | 17.96 | 22.75 | 23.95 |
| Vaseline | 19.72 | 18.62 | 16.43 | 20.81 | 21.91 |
| Glucide | 0.01 | 0.01 | 0.02 | 0.00 | 0.00 |
| Microwax 3W-835 | 4.69 | 7.04 | 11.73 | 2.35 | 0.00 |
*Reference formula I II-E only is used for the comparison purpose
For preparing above-mentioned sample III-A-E, under about 95 ℃,, and under vacuum and about 65 ℃, in the thermal capacitance device, make other composition and its blend with wax fusion (in embodiment A to D).To be filled in the pipe through the product of blend.Described product can be expressed into from pipe on the artificial tooth of strips.Band from product III-A-C can be picked up, and can for example be placed on suitable position, does not almost have or do not have residue on the finger.Band from product III-E can't be picked up and be placed, because they adhere to the artificial tooth surface, and leaves a large amount of residues on finger.
Method of testing
Can measure the bioerosion of the present composition by the following method: open the water source, water was flowed about 30 minutes on sample sampling top, sampling simultaneously is positioned on the silk screen, as shown in fig. 1.The laboratory tap of water source for regulating, so that temperature is 39 ℃ ± 1 ℃, and flow velocity is 16mL/s ± 1mL/s.Use funnel to assemble current, and help to eliminate small pressure and temperature fluctuation effect in the waterline.The silk screen grid has the square openings of about 0.22cm * 0.22cm (0.09 inch * 0.09 inch), and is placed on according to 6.4cm under the funnel tip (2.5 inches) and locates, and wherein said funnel is clipped in order on the becket that supports by pincers.The sample sampling of heavy 0.025g is placed on the silk screen, and in the time of 0,10 and 30 minute, takes image, to follow the tracks of the bioerosion of sampling.After 30 minutes, take off the silk screen that comprises the residue of sampling, and vacuum and 60 ℃ of following heating 1 hour, to remove all residual water.After the heating period, read final weight, to calculate the loss in weight that causes because of bioerosion.Use the average of 3 sampling of each sample, calculate the bioerosion time and the loss in weight.If under these test conditions, described compositions did not stay visible residue, thin film or thin slice after about 30 minutes, if and/or under these test conditions, described compositions after about 30 minutes not easy-to-use hands with the isolated in form of one or more sheets or strip down, if and/or under these test conditions, described compositions after about 30 minutes residual by (described compositions initial weight) weight less than about 2%, less than about 4%, less than about 6%, and/or less than about 8% residue, but then described compositions is bioerosion.Above-mentioned bioerosion test also can be implemented at maximum 8 hours a plurality of time points.
Can measure aggressive tack: 1. take off goods from packaging material by the following method; 2. described goods are placed on the exsiccant acrylic acid upper jaw artificial tooth jaw part, and make facing downwards; 3. exerted pressure about 3 to 10 seconds with finger; 4. remove finger pressure subsequently; 5. make the artificial tooth turned upside down then, make facing upward.In one embodiment, if following situation, then described goods show aggressive tack: i. is during step 1 is to 2, described goods do not adhere to finger, ii. step 3 to 4 in, almost do not have or do not have residue to stay on the finger, with iii. in step 5, described goods at least about 10 to 30 seconds, or can not break away from artificial tooth in 1 minute when turned upside down.
In another embodiment, if following situation, then described goods show aggressive tack: i. is during step 1 is to 4, described goods do not adhere to finger and ii. in step 5, described goods are when turned upside down, at least about 10 to 30 seconds, or in 1 minute, can not break away from artificial tooth.
In another embodiment, if in step 5, described goods at least about 10 to 30 seconds, or can not break away from artificial tooth in 1 minute when turned upside down, and then described goods show aggressive tack.
Also can measure the aggressive tack of goods of the present invention by the following method:
A.2 second in 19.6N (2000 fors) power 2.5cm (between the cylindrical needle (making) and polymethyl methacrylate flat board of 1 ") diameter by polymethyl methacrylate, extrusion 5mm diameter plate-like (0.67mm is thick) goods sample,
B. with the speed pulling probe of 1mm/ second, and the record peak force,
C. under the situation that no specimen between two surfaces is mingled with repeating step and
D. calculate: be the cross-sectional area of aggressive tack=(peak force the during peak force when sample is arranged-the no specimen)/sample disk of unit with gram/square centimeter
In one embodiment, in step a, adopt the power that applies of 2.45N (250 fors), and in step b to d, measure viscosity, the method above repeating;
If adopt viscosity that the power that applies of 2.45N (250 fors) records less than about 2.45,4.90,9.81,19.6 or 49.0kPa (25,50,100,200 or 500 gram/square centimeter), and the viscosity that the power that applies that adopts 19.6N (2000 fors) records is greater than about 19.6,49.0,98.1,196.1,490.3,980.7 or 2451.7kPa (200,500,1000,2000,5000,10000 or 25000 gram/square centimeter), and any combination of these values, then described goods have aggressive tack.
Can measure the modulus G ' of the present composition by the following method:
A. use the parallel-plate anchor clamps of (500 gram) compression stress that has 4.90N, the sample disk of diameter 8mm and thick 0.67mm is loaded on the ARES flow graph.If described sample is flowable, then use the material of capacity to fill 1mm gap on the 25mm diameter parallel-plate anchor clamps.
B. strain is set at 0.02%,
C. comprising under the rate of scanning of 1Hz, measuring modulus G '.
By the following method, measure the normalization tripping force of goods of the present invention and free the force rate rate:
Instrument: use 5544 type Instron testing machines.Annual description according to manufacturer, the calibration force cell.By making the power that produces by binding agent be positioned at the force cell recommended operating range, determine the selection of force cell.This typical case between full capacity 10% to 90% between.
Test fixture: the geometry of using cylindrical needle and flat board is as test fixture.Described probe is made by PMMA, and surface area is 0.2
To 10 square centimeters.For base plate, use identical PMMA material, but be thin slice shape, thick 0.64cm (
1/
4").Be cut into the plate of 15.2cmx15.2cm (6 " x6 "), to clip on the Instron testing machine.
Aqua liquid: use the artificial saliva who comprises the multiple salt of low content to come the hydration binding agent.
The artificial saliva forms
| Composition | Measure every liter |
| K 2HPO 4 | 4.2g |
| KH 2PO 4 | 3.2g |
| KOH | 2 granules |
| The stock solution of inorganic matter stock solution-every 100mL of KCl 8g-NaCl 8g-Na2SO4 0.264g-MgCl2.6H2O 0.7687 (or the anhydrous MgCl2 of 0.36g) | 5mL |
Binding agent: 0.1 to 1.0g binding agent is administered on the probe.
Hydration: aqua liquid (0.2mL to 2.0mL artificial saliva) suction is moved on on the adhesive surface.Make molectron hydration 20 minutes or more of a specified duration then.
Method of testing: after the sample hydration, attach it on the Instron testing machine, and, implement test via computer control.Described method is made of following steps:
(a) be forced into 7.35N (750gf) to 73.5N (7500 gram force)
(b) kept 2 minutes adding to depress
(c) compression stress is reduced to 1.96N (200gf)
(d) keep (1 minute)
(e) spur with 1mm/s speed
(f) record peak value tripping force
(g) calculate " normalization tripping force "=(peak value tripping force)/(detecting probe surface is long-pending);
With gram/square centimeter is unit record
(h) for commercially available Fixodent Original adhesive for denture (by P﹠amp; G commercialization manufacturing obtains), or for following reference prescription, repeating step A to F:Ca (47.5%)/Zn (17.5%) MVE/MA salt 33%, sodium carboxymethyl cellulose 20%, mineral oil USP (40 ℃ are 65-75cst down) 23.93%, vaseline USP (denseness be 17 to 20mm) 21.87%, colloidal silica 1.14% and Opatint OD1646 0.06%; The proper method for preparing this reference prescription is disclosed among the US 6,617,374 of the US 5,073,604 of Holeva K. and Rajaiah J.
(i) calculate " tripping force ratio "=(the peak value tripping force of sample binding agent)/(the peak value tripping force of FixodentOriginal)
Data: with the minimum repetition of each sample 3 times, and the meansigma methods of record " normalization tripping force " and " tripping force ratio ".
Specifically, by in described method, adopting following parameter, can measure the normalization tripping force and free the force rate rate: the 0.25g binding agent; The probe of diameter 2.5cm (1 inch); Hydration time 20 minutes; And the compression stress of 73.5N (7500g).
By the following method, measure " normalization seepage discharge " and " oozing out ratio " of goods of the present invention:
A. initial sample that will heavily about 0.50g is loaded on the cylindrical needle of being made by polymethyl methacrylate of diameter 2.5cm (1 inch) equably,
B. probe is placed on equally on the 1.2mm base plate of making by polymethyl methacrylate,
C. apply 7.35N (750 gram force), kept 90 seconds,
D. in the time of 90 seconds, remove the material that also weighing has been oozed out,
E. calculate " normalization seepage discharge "=(seepage discharge/initial sample is heavy) * 100,
F. use commercially available Fixodent Original (by P﹠amp; The adhesive for denture cream that the G commercialization is made), or for following reference prescription, repeating step a to e:
Ca (47.5%)/Zn (17.5%) MVE/MA salt 33%, sodium carboxymethyl cellulose 20%,
Mineral oil USP (40 ℃ down for 65-75cst) 23.93%, vaseline USP (denseness be 17 to 20mm) 21.87%, colloidal silica 1.14% and OpatintOD1646 0.06%; The proper method for preparing this reference prescription is disclosed among the US 6,617,374 of the US 5,073,604 of Holeva K. and Rajaiah J.,
G. calculate the normalization seepage discharge of the normalization seepage discharge/FixodentOriginal of " oozing out ratio "=sample binding agent,
H. with the minimum repetition of each sample 3 times, and the meansigma methods of record " normalization seepage discharge " and " oozing out ratio ".
The relevant portion of all documents of quoting in detailed Description Of The Invention all is incorporated herein with way of reference.Quoting of any document may not be interpreted as its approval as prior art of the present invention.
Although illustrated and described the present invention with specific embodiments, it will be apparent to those skilled in the art that many other variations and modifications may be made in the case of without departing from the spirit and scope of protection of the present invention.Therefore, in additional claims, comprise all such changes and modifications that belong in the scope of the invention consciously.
Claims (15)
1. Denture adhesive compositions, described compositions comprises:
A) the adhesive for denture component of safety and effective bonding amount;
B) water-msoluble ingredients of safety and effective dose, described water-msoluble ingredients are selected from the group of being made up of water-insoluble thermoplastic component, water-insoluble liquid component and their mixture; Wherein said compositions has the normalization tripping force of 1100 to 12,000 gram/square centimeters, or 1.1 to 10 tripping force ratio.
2. compositions as claimed in claim 1, wherein said compositions are to comprise the goods of one deck at least.
3. compositions as claimed in claim 1, wherein said compositions also comprises solvent.
4. compositions as claimed in claim 1, but wherein said compositions is bioerosion.
5. compositions as claimed in claim 1, wherein said compositions are cream, paste, gel, liquid, band, wafer, goods or their mixture.
6. compositions as claimed in claim 1, the content of wherein said water-msoluble ingredients are 2% to 90% by weight, and preferably wherein said content is 45% to 60% by weight.
7. compositions as claimed in claim 1, described compositions comprises the water-insoluble thermoplastic component, described water-insoluble thermoplastic component is selected from the group of being made up of following: rubber, native paraffin, synthetic wax, polrvinyl chloride, nylon, fluorocarbon, polyurethane prepolymer, polyethylene, polystyrene, polypropylene, celluosic resin, acrylic resin, vaseline, polyvinyl acetate, and their mixture, preferably wherein said water-insoluble thermoplastic component is selected from the group of being made up of following: native paraffin, synthetic wax, vaseline, polyethylene, and their mixture, even more preferably wherein said water-insoluble thermoplastic component is to have 70 ℃ of microwaxes to 90 ℃ of fusing points.
8. goods as claimed in claim 1, wherein said adhesive for denture component is selected from the group of being made up of following: cellulose derivative, starch derivatives, carbohydrate derivative, the poly(ethylene oxide) class, polyethylene glycols, polyvinyl alcohol, carrageenin, alginate, karaya, xanthan gum, guar gum, gelatin, Algin, Tragacanth, chitosan, acrylamide polymer, carbopol, polyamine, poly quaternary ammonium compound, polyvinylpyrrolidone, AVE/MA, AVE/MA salt, the salt-mixture of AVE/MA, polymeric acid, polysalt, polyol, and their mixture.
9. goods as claimed in claim 8, salt or salt-mixture that wherein said adhesive for denture component is AVE/MA, preferably wherein said adhesive for denture component is selected from the group of being formed by the salt of AVE/MA or salt-mixture, described salt comprises the cationic salts functional group of cation, and described cation is selected from the group of being made up of following: the cation of periodic table of elements IA family and 2A family, yttrium, titanium, zirconium, vanadium, chromium, manganese, ferrum, nickel, copper, zinc, boron, aluminum and their mixture.
10. goods as claimed in claim 13, wherein said cation is selected from the group of being made up of following: strontium, zinc, ferrum, magnesium, calcium, sodium and their mixture, preferably wherein said salt are selected from calcium/sodium salt of calcium/zinc salt of the group of being made up of following: AVE/MA, magnesium/zinc of AVE/MA/sodium salt, AVE/MA, the zinc salt of AVE/MA and their mixture.
11. compositions as claimed in claim 1, wherein said adhesive for denture component comprises the cellulose derivative of 5% to 60% content by weight, described cellulose derivative is selected from the group of being made up of following: hydroxyethyl-cellulose, hydroxypropyl emthylcellulose, sodium carboxymethyl cellulose, corn starch and their mixture, preferably wherein said cellulose derivative is a sodium carboxymethyl cellulose.
12. compositions as claimed in claim 1, described compositions comprises the water-insoluble liquid component, and described water-insoluble liquid component is selected from the group of being made up of following: mineral oil, natural and artificial oil, fat, siloxanes, silicone derivative, polydimethylsiloxane, organic siliconresin, hydrocarbon, hydrocarbon derivative, quintessence oil, caprylic/capric triglyceride, corn, Semen sojae atricolor, Semen Gossypii, Semen Ricini, Petiolus Trachycarpi oil, Oleum Cocois, vegetable oil, animal oil, fish oil, oleic acid and their mixture.
13. compositions as claimed in claim 1, wherein said normalization tripping force is 1200 to 10,000 gram/square centimeter, preferably wherein said normalization tripping force is 1300 to 5000 gram/square centimeters, more preferably wherein said normalization tripping force is 1500 to 2500 gram/square centimeters, even more preferably wherein said normalization tripping force is 1750 to 2500 gram/square centimeters.
14. compositions as claimed in claim 1, wherein said tripping force ratio is 1.8 to 10, preferably wherein said tripping force ratio is 1.2 to 6, and more preferably wherein said tripping force ratio is 1.3 to 4, even more preferably wherein said tripping force ratio is 1.3 to 2.5.
15. one kind in needing the object of adhesive for denture, make described adhesive for denture reduce exudative, improve retentivity, increase the food sealing characteristics, improve simplicity, the cleaning simplicity of improving residual adhesive for denture and the method for their any combination used, described method comprises goods as claimed in claim 1 is administered on artificial tooth, oral cavity or both, and subsequently described artificial tooth is fixed on the described oral cavity.
Applications Claiming Priority (30)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73524305P | 2005-11-09 | 2005-11-09 | |
| US73513605P | 2005-11-09 | 2005-11-09 | |
| US73487405P | 2005-11-09 | 2005-11-09 | |
| US73508805P | 2005-11-09 | 2005-11-09 | |
| US73513505P | 2005-11-09 | 2005-11-09 | |
| US60/735,088 | 2005-11-09 | ||
| US60/734,874 | 2005-11-09 | ||
| US60/735,135 | 2005-11-09 | ||
| US60/735,243 | 2005-11-09 | ||
| US60/735,136 | 2005-11-09 | ||
| US76051606P | 2006-01-20 | 2006-01-20 | |
| US76052806P | 2006-01-20 | 2006-01-20 | |
| US76052706P | 2006-01-20 | 2006-01-20 | |
| US76052606P | 2006-01-20 | 2006-01-20 | |
| US76066006P | 2006-01-20 | 2006-01-20 | |
| US60/760,516 | 2006-01-20 | ||
| US60/760,526 | 2006-01-20 | ||
| US60/760,528 | 2006-01-20 | ||
| US60/760,660 | 2006-01-20 | ||
| US60/760,527 | 2006-01-20 | ||
| US60/760,711 | 2006-01-20 | ||
| US11/590,231 | 2006-10-31 | ||
| US11/590,225 | 2006-10-31 | ||
| US11/590,232 | 2006-10-31 | ||
| US11/590,224 | 2006-10-31 | ||
| US11/590,111 | 2006-10-31 | ||
| US11/590,233 | 2006-10-31 | ||
| US11/590,191 | 2006-10-31 | ||
| US11/590,145 | 2006-10-31 | ||
| PCT/US2006/044031 WO2007056608A1 (en) | 2005-11-09 | 2006-11-09 | Denture adhesive compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101304723A true CN101304723A (en) | 2008-11-12 |
| CN101304723B CN101304723B (en) | 2013-07-10 |
Family
ID=40066510
Family Applications (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2006800398582A Pending CN101296679A (en) | 2005-11-09 | 2006-11-09 | Denture adhesive articles |
| CNA2006800418815A Pending CN101304722A (en) | 2005-11-09 | 2006-11-09 | Denture adhesive article packaging |
| CNA2006800400440A Pending CN101296681A (en) | 2005-11-09 | 2006-11-09 | Denture adhesive articles |
| CNA2006800413120A Pending CN101299984A (en) | 2005-11-09 | 2006-11-09 | Denture adhesive articles |
| CNA2006800418779A Pending CN101304721A (en) | 2005-11-09 | 2006-11-09 | Denture adhesive compositions |
| CNA2006800399443A Pending CN101296680A (en) | 2005-11-09 | 2006-11-09 | Denture adhesive articles |
| CNA2006800413224A Pending CN101299985A (en) | 2005-11-09 | 2006-11-09 | Denture adhesive articles |
| CN200680041902.3A Active CN101304723B (en) | 2005-11-09 | 2006-11-09 | Denture adhesive compositions |
Family Applications Before (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2006800398582A Pending CN101296679A (en) | 2005-11-09 | 2006-11-09 | Denture adhesive articles |
| CNA2006800418815A Pending CN101304722A (en) | 2005-11-09 | 2006-11-09 | Denture adhesive article packaging |
| CNA2006800400440A Pending CN101296681A (en) | 2005-11-09 | 2006-11-09 | Denture adhesive articles |
| CNA2006800413120A Pending CN101299984A (en) | 2005-11-09 | 2006-11-09 | Denture adhesive articles |
| CNA2006800418779A Pending CN101304721A (en) | 2005-11-09 | 2006-11-09 | Denture adhesive compositions |
| CNA2006800399443A Pending CN101296680A (en) | 2005-11-09 | 2006-11-09 | Denture adhesive articles |
| CNA2006800413224A Pending CN101299985A (en) | 2005-11-09 | 2006-11-09 | Denture adhesive articles |
Country Status (1)
| Country | Link |
|---|---|
| CN (8) | CN101296679A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102361619A (en) * | 2009-03-09 | 2012-02-22 | 3M创新有限公司 | Composition for attaching a dental facing on a dental support structure, process and use thereof |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101797209A (en) * | 2010-04-07 | 2010-08-11 | 丹尼斯克（张家港）亲水胶体有限公司 | False teeth base tray adhesive ointment and preparation process thereof |
| CN102038613B (en) * | 2010-12-23 | 2012-11-28 | 五河克菱保健科技有限公司 | Denture adhesive cushion |
| CN102382472B (en) * | 2011-08-19 | 2012-12-12 | 天津医科大学口腔医院 | Edge molding material for dental complete denture impression |
-
2006
- 2006-11-09 CN CNA2006800398582A patent/CN101296679A/en active Pending
- 2006-11-09 CN CNA2006800418815A patent/CN101304722A/en active Pending
- 2006-11-09 CN CNA2006800400440A patent/CN101296681A/en active Pending
- 2006-11-09 CN CNA2006800413120A patent/CN101299984A/en active Pending
- 2006-11-09 CN CNA2006800418779A patent/CN101304721A/en active Pending
- 2006-11-09 CN CNA2006800399443A patent/CN101296680A/en active Pending
- 2006-11-09 CN CNA2006800413224A patent/CN101299985A/en active Pending
- 2006-11-09 CN CN200680041902.3A patent/CN101304723B/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102361619A (en) * | 2009-03-09 | 2012-02-22 | 3M创新有限公司 | Composition for attaching a dental facing on a dental support structure, process and use thereof |
| US8597719B2 (en) | 2009-03-09 | 2013-12-03 | 3M Innovative Properties Company | Composition for attaching a dental facing on a dental support structure, process and use thereof |
| CN102361619B (en) * | 2009-03-09 | 2015-07-22 | 3M创新有限公司 | Composition for attaching a dental facing on a dental support structure, process and use thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101304721A (en) | 2008-11-12 |
| CN101296679A (en) | 2008-10-29 |
| CN101304722A (en) | 2008-11-12 |
| CN101299984A (en) | 2008-11-05 |
| CN101299985A (en) | 2008-11-05 |
| CN101296681A (en) | 2008-10-29 |
| CN101304723B (en) | 2013-07-10 |
| CN101296680A (en) | 2008-10-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20070185237A1 (en) | Denture adhesive articles | |
| CA2628101C (en) | Denture adhesive articles | |
| US20070129460A1 (en) | Denture adhesive articles | |
| CN101304723B (en) | Denture adhesive compositions | |
| RU2448678C2 (en) | Dental adhesion compositions |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |