CN101301196A - Electroencephalogram monitoring device of sedation depth of anaesthesia - Google Patents
Electroencephalogram monitoring device of sedation depth of anaesthesia Download PDFInfo
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- CN101301196A CN101301196A CNA2007100405648A CN200710040564A CN101301196A CN 101301196 A CN101301196 A CN 101301196A CN A2007100405648 A CNA2007100405648 A CN A2007100405648A CN 200710040564 A CN200710040564 A CN 200710040564A CN 101301196 A CN101301196 A CN 101301196A
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Abstract
The invention provides an electroencephalogram monitoring device of anesthesia depth including a brain wave collection amplification and data processor (1) and a display (2), which is characterized in that the electroencephalogram monitoring device also includes a computer (3), a software main body (4) mounted in the computer (3) and a brain function index analyzing module (46), wherein the computer (3) and the brain wave collection amplification and data processor (1) are bidirectionally connected by an USB bus, and the computer (3) sends processing results to the display (2) to display. The electroencephalogram monitoring device has advantages of: 1. more accurately using anesthetic to stabilize maintenance of anesthesia and synchronously reducing dosage of anesthetic; 2. ensuring that patients have no aesthesia during operation and no memory after operation; 3. providing indications of quick sobriety and extubation, increasing revival quality after operation and shortening residence time in resuscitation room of patients; 4. more completely resuming consciousness of patients after operation; 5. instructing dosage of sedative for ICU patients to maintaining the patients at a more stable sedation level.
Description
Technical field
The present invention relates to a kind of monitoring device that is used for the clinical anesthesia sedation degree, particularly a kind of device that uses electroencephalogram to monitor sedation depth of anaesthesia.
Background technology
Depth of anesthesia is the problem that the Anesthetist was concerned about always, how to realize high-quality anaesthetic effect by effectively guarding, and is very important for clinical operation, is Anesthetist's technical barrier to be solved always.
About the brain wave waveform that electroencephalogram write down, be that feature is described normally with wave amplitude, frequency and phase place, therefore, the existing EEG that adopts is used to reflect that depth of anesthesia is to describe with the temporal signatures of EEG, the main geometric properties of analyzing the EEG waveform, therefore, still fail to obtain gratifying solution effect.
Summary of the invention
In sum, structure how to improve existing electroencephalograph makes it have the function that the brain function index is analyzed, the analytic function that particularly has bispectral index, make it to can be used for reflecting depth of anesthesia, this is a technical problem to be solved by this invention, for this reason, the object of the present invention is to provide a kind of electroencephalogrammonitoring monitoring device of sedation depth of anaesthesia.
Technical scheme of the present invention is as follows:
Electroencephalogrammonitoring monitoring device according to a kind of sedation depth of anaesthesia of the present invention, comprise brain wave collection amplification and data processor, display, characteristics are to set up brain function index analysis module between described two parts, it is arranged at computer-internal, and the platform computer is transported control, is handled thus, send display to show result at last.
Particularly, described brain function index analysis module comprises that the EEG signaling module that connects with flow process successively, signal digitalized module, digital filter, FFT computing module, β are than subparameter module; After the burst that connects this digital filter and become flow process to connect successively suppress detection module, burst suppresses the subparameter module; And after connect this FFT computing module and become bipolarity computing module that flow process connects successively, wave spectrum is than parameter module synchronously, and described β suppresses the subparameter module than subparameter module, burst and is connected with two index parameters weighted sum modules than parameter module with wave spectrum synchronously;
Amplifier in described brain wave collection amplification and the processor comprises EEG signals amplifying circuit, channel selector switch, A/D convertor circuit, eeg amplifier data buffer memory, usb circuit and the USB interface that connects with circuit successively.
More specifically, described amplifying circuit is a low simulation enlargement ratio amplifier, and its bandwidth is 1～1000Hz, and amplification is 50, connects one 16 high bit rate GTG A/D change-over circuits thereafter;
Advantage of the present invention is:
1) can use anesthetics more accurately, make keeping of anesthesia more steady, can reduce the consumption of anesthetics simultaneously.
2) guarantee in patient's art not have know, postoperative is memoryless.
3) provide the indication of fast clear-headed and tube drawing, improve the postoperative quality of reviving, shorten the recovery room time of staying.
4) make the postoperative consciousness recovery more complete.
5) be used to instruct patient's ICU tranquilizer consumption, make patient maintain level of sedation more stably.
Description of drawings
Fig. 1 is a block chart of the present invention;
Fig. 2 is a software agent module map of the present invention;
Fig. 3 is the brain function index analysis module map among the present invention;
Fig. 4 is the amplifier architecture block diagram among the present invention; And
Fig. 5 is the analog signal amplifier sketch map among the present invention.
The specific embodiment
Provide better embodiment of the present invention according to Fig. 1～Fig. 5 below, and described in detail, so that those skilled in the art's energy easy to understand architectural feature of the present invention and function characteristics, rather than be used for limiting scope of the present invention.
Referring to Fig. 1～Fig. 3
Brain wave patterns demonstrates the spontaneous and rhythmic electrical activity of brain cell group, and brain wave generally is to describe with features such as wave amplitude, frequency and phase places.During general anesthesia, the electroencephalogram frequency deepens with anesthesia or shoals to be the order variation, is functional relationship with anesthetic concentration, is used to reflect depth of anesthesia.Maturation along with fast Fourier transform techniques, increasing EEG frequency domain character but can be used to reflect depth of anesthesia, the original EEG signals of time-amplitude relation is converted to the relation of frequency-power, and derivation goes out a plurality of quantification parameters, as bispectral index (BIS), marginal frequency (SEF), intermediate frequency (MF) etc.
It is to use the nonlinear phase locking principle original EEG waveform is handled that BIS EEG analyzes, it is the analysis that on the basis of power spectrumanalysis, has added the correlation function spectrum again, both measure the linear composition (frequency and power) of EEG, analyzed the non-linear relation (position phase and harmonic wave) between the EEG wavelet again.By analyzing the mutual relation of high-order harmonic wave in each frequency, carry out the quantitative assay that the position is coupled between the EEG signal frequency.Clear-headed people has significant position to be coupled or phase locking on the EEG frequency band.Therefore BIS analyzes the information from Fourier analysis has been carried out clearer expression, has not only comprised more original EEG information, and has got rid of many interference factors to EEG information more.The variable of BIS is to express by the value that multivariate mathematical regression Equation for Calculating produces.Bispectral analysis is the phase place coupling (phase coupling) between quantitative EEG frequency, frequency and amplitude information have been comprised, the feature of the linear behavior of phase place coupling right and wrong, thereby bispectral analysis can accurately detect and quantitatively linearity and nonlinear change between signal, can reflect more accurately that depth of anesthesia changes.The BIS numerical range is 0～100, and numerical value is big more, and is clear-headed more, otherwise points out corticocerebral inhibition more serious.
Bispectral index (bispectral index, BIS) comprised time domain, electroencephalogram (EEG) the quantitative analysis index of frequency domain and higher-order spectrum variable (double-spectrum analysis) three specific characters, it is by a specific nonlinear algorithm (Aspect Medical Systems, Natick, USA), with four different EEG parameters, suppression ratio (burst suppression ratio promptly happens suddenly, BSR), " QUAZI ", the relative synchronicity (synch fast slow) of β ratio (betaratio) and fast slow wave, comprehensively become the dimensionless number of a 100-0, be used to represent the inhibition degree of brain.
See also Fig. 4 and Fig. 5
Amplifier of the present invention and the different unique distinction of traditional approach are the unique design at the brain function index analysis of EEG signals amplifying circuit.
1. ultrabroad band
Adopt the ultrabroad band design to adapt to the requirement of brain function index analysis, conventional brain electric frequency band width mostly is 1-60Hz, and this amplifier bandwidth scope is 1-1000Hz, except done certain adjustment on traditional circuit, has also used low simulation enlargement ratio technology.
2. low simulation enlargement ratio
Because EEG signals is extremely faint, traditional mentality of designing is by the mode of plural serial stage EEG signals to be amplified (analogue signal) at the EEG signals amplifier section to amplify 10000 times, in the traditional circuit amplifying circuit, when being amplified, EEG signals also many interfering signals are amplified, the static noise of preamplifying circuit also is exaggerated simultaneously, these interfering signals and noise signal are mixed in the EEG signals, be difficult to distinguish, and the waveform that can make some frequency is amplified to the amplitude of ending, cause whole wave distortion, EEG signals can not truly be restored, these not only bring difficulty to the later stage signal processing, the most important thing is to influence the accuracy of brain electricity analytical.
Amplifier of the present invention, then only adopted the one-level amplifying circuit of 50 times of amplifications, can solve existing problem in the traditional circuit effectively, but the too small meeting of enlargement ratio produces certain difficulty to the signal processing in later stage, in order to remedy this deficiency, adopted the A/D change-over circuit of 16 high bit rate GTGs,, obtained very satisfied effect far above traditional 8.
Claims (4)
1, a kind of electroencephalogrammonitoring monitoring device of sedation depth of anaesthesia, comprise brain wave collection amplification and data processor (1), display (2), it is characterized in that, also have a computer (3) and be installed on this computer (3) inner software agent (4) and brain function index analysis module (46), this computer (3) becomes double-way connection with data processor (1) with usb bus with brain wave collection amplification, and this computer (3) send display (2) to show result.
2, the electroencephalogrammonitoring monitoring device of sedation depth of anaesthesia according to claim 1, it is characterized in that, described brain function index analysis module (46) comprises EEG signaling module (460), signal digitalized module (461), digital filter (462), the FFT computing module (463) that becomes flow process to connect successively, β is than subparameter module (464), two index parameters weighted sum modules (469); The digital filter (462) that connects with flow process, burst suppress detection module (465) successively, burst suppresses subparameter module (466), two index parameters weighted sum modules (469); And the FFT computing module (464) that connects with flow process successively, bipolar computing module (467), synchronous wave spectrum are than parameter module (468), two index parameters weighted sum modules (469).
3, the electroencephalogrammonitoring monitoring device of sedation depth of anaesthesia according to claim 1, it is characterized in that described brain wave collection amplification comprises EEG signals amplifying circuit (100), channel selector switch (101), A/D convertor circuit (102), eeg amplifier data buffer memory (104), usb circuit (105) and the USB interface (106) that becomes circuit to connect successively with amplifier (10) in the processor (1).
4, the electroencephalogrammonitoring monitoring device of sedation depth of anaesthesia according to claim 3, it is characterized in that, described EEG signals amplifying circuit (100) is a low simulation enlargement ratio amplifier, bandwidth is 1～1000Hz, amplification is 50, connects one 16 high bit rate GTG A/D change-over circuits thereafter.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104307069A (en) * | 2014-10-17 | 2015-01-28 | 广州军区广州总医院 | Dual-channel anesthesia target controlled infusion control method adopting propofol and sufentanil |
| CN104470425A (en) * | 2012-05-30 | 2015-03-25 | 伊西斯创新有限公司 | Perception loss detection |
| CN105030234A (en) * | 2015-06-26 | 2015-11-11 | 迈德高武汉生物医学信息科技有限公司 | Brain wave monitor as well as intelligent monitoring system and method thereof |
| CN105072988A (en) * | 2013-02-14 | 2015-11-18 | 灿美工程股份有限公司 | Method and apparatus for measuring anesthetic depth using cepstrum tenique |
| CN105167745A (en) * | 2015-06-05 | 2015-12-23 | 安徽华艾生物科技有限公司 | Monitoring device for depth of anesthesia |
| US9849241B2 (en) | 2013-04-24 | 2017-12-26 | Fresenius Kabi Deutschland Gmbh | Method of operating a control device for controlling an infusion device |
| CN107920951A (en) * | 2015-06-12 | 2018-04-17 | 株式会社美迪安纳 | Automatic device for resuscitating heart and pulmones |
| CN108618778A (en) * | 2018-05-07 | 2018-10-09 | 惠州善雅医疗器械有限公司 | A kind of deep index calculation method of fiber crops and anaesthesia depth monitor |
| CN109394210A (en) * | 2018-12-14 | 2019-03-01 | 张维维 | A kind of department of anesthesia's anesthesia depth monitor |
| CN109646146A (en) * | 2018-12-03 | 2019-04-19 | 青岛大学 | One kind being used for experimental animal etherization system and its operating method |
| WO2019127557A1 (en) * | 2017-12-29 | 2019-07-04 | 深圳迈瑞生物医疗电子股份有限公司 | Method for identifying anesthetic drug, and method and device for processing anesthesia electroencephalography signal |
| CN113729730A (en) * | 2021-09-03 | 2021-12-03 | 河南省安信科技发展有限公司 | Anesthesia state monitoring system based on electroencephalogram analysis technology |
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2007
- 2007-05-11 CN CNA2007100405648A patent/CN101301196A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104470425A (en) * | 2012-05-30 | 2015-03-25 | 伊西斯创新有限公司 | Perception loss detection |
| US10542905B2 (en) | 2012-05-30 | 2020-01-28 | Oxford University Innovation Limited | Perception loss detection |
| CN105072988A (en) * | 2013-02-14 | 2015-11-18 | 灿美工程股份有限公司 | Method and apparatus for measuring anesthetic depth using cepstrum tenique |
| CN105072988B (en) * | 2013-02-14 | 2017-09-15 | 灿美工程股份有限公司 | The method and apparatus analyzed based on brain wave signal |
| US9849241B2 (en) | 2013-04-24 | 2017-12-26 | Fresenius Kabi Deutschland Gmbh | Method of operating a control device for controlling an infusion device |
| CN104307069A (en) * | 2014-10-17 | 2015-01-28 | 广州军区广州总医院 | Dual-channel anesthesia target controlled infusion control method adopting propofol and sufentanil |
| CN104307069B (en) * | 2014-10-17 | 2017-05-31 | 广州军区广州总医院 | Target controlled infusion control device is anaesthetized using the binary channels of Propofol and sufentanil |
| CN105167745A (en) * | 2015-06-05 | 2015-12-23 | 安徽华艾生物科技有限公司 | Monitoring device for depth of anesthesia |
| CN107920951A (en) * | 2015-06-12 | 2018-04-17 | 株式会社美迪安纳 | Automatic device for resuscitating heart and pulmones |
| CN105030234A (en) * | 2015-06-26 | 2015-11-11 | 迈德高武汉生物医学信息科技有限公司 | Brain wave monitor as well as intelligent monitoring system and method thereof |
| WO2019127557A1 (en) * | 2017-12-29 | 2019-07-04 | 深圳迈瑞生物医疗电子股份有限公司 | Method for identifying anesthetic drug, and method and device for processing anesthesia electroencephalography signal |
| CN108618778A (en) * | 2018-05-07 | 2018-10-09 | 惠州善雅医疗器械有限公司 | A kind of deep index calculation method of fiber crops and anaesthesia depth monitor |
| CN108618778B (en) * | 2018-05-07 | 2019-07-02 | 惠州善雅医疗器械有限公司 | A kind of deep index calculation method of fiber crops and anaesthesia depth monitor |
| CN109646146A (en) * | 2018-12-03 | 2019-04-19 | 青岛大学 | One kind being used for experimental animal etherization system and its operating method |
| CN109394210A (en) * | 2018-12-14 | 2019-03-01 | 张维维 | A kind of department of anesthesia's anesthesia depth monitor |
| CN113729730A (en) * | 2021-09-03 | 2021-12-03 | 河南省安信科技发展有限公司 | Anesthesia state monitoring system based on electroencephalogram analysis technology |
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