CN101297838A - Pharmaceutical combination for preventing birth-defect and improving memory - Google Patents
Pharmaceutical combination for preventing birth-defect and improving memory Download PDFInfo
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- CN101297838A CN101297838A CNA2008101139618A CN200810113961A CN101297838A CN 101297838 A CN101297838 A CN 101297838A CN A2008101139618 A CNA2008101139618 A CN A2008101139618A CN 200810113961 A CN200810113961 A CN 200810113961A CN 101297838 A CN101297838 A CN 101297838A
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Abstract
The invention relates to a pharmaceutical composition for prevention of birth defects and improvement of memory which comprises largehead atractylodes rhizome, coastal glehnia root, compound vitamin B, vitamin D, major elements of calcium and magnesium and trace elements of zinc, selenium and iron. The composition is mainly applicable to pre-pregnancy women, pregnant women and lactating mothers and can effectively prevent the birth defects and improve the memory; furthermore, the composition has the effects of health care and invigoration and does not have any side effects even in long-term application.
Description
Technical field:
The present invention relates to the Medicines and Health Product technical field.In particular for prevention birth defect and the pharmaceutical composition that improves memory.
Background technology:
Birth defect is meant fetus in parent and in the organ formative process of birth back, by embryo due to the various factors effect and paedomorphosis disorder, comprises that morphosis is unusual, 4 types of physiological metabolism obstacle, congenital mental retardation and intrauterine growth retardations etc.Various countries' birth defect incidence rate is up to about 5% of the birth sum, and is great to the population quality influence, causes white elephant for family, society, become the common great public health problem of paying close attention in the present whole world.
The pathogenic factors of birth defect is very complicated, and inherited genetic factors is arranged, and environmental factors also has other multiple uncertain factor.Environmental factors comprises biological factor, physical factor, chemical factor; The embryo is subjected to the injury of environment harmful factor and other multiple uncertain factor, the birth defect sickness rate is increased, and eliminate these harmful factors, and the birth defect sickness rate is lowered.
Pharmaceutical composition of the present invention is a policy of following prenatal and postnatal care, by eliminating the birth defect factor that causes to the embryo, the generation of prevention birth defect reaches the purpose that lowers the birth defect sickness rate, simultaneously user there is the memory impairments of improvement, favourable mothers and sons two generations's health; Said composition comprises the Rhizoma Atractylodis Macrocephalae, Radix Glehniae, compound vitamin B, vitamin D and macroelement calcium, magnesium and trace element zinc, selenium, ferrum, and wherein compound vitamin B comprises vitamin B
1, vitamin B
2, vitamin B
6, vitamin B
12, folic acid, nicotiamide, pantothenic acid and biotin.
The Rhizoma Atractylodis Macrocephalae is a kind ofly can invigorating the spleen and benefiting QI be arranged as the QI invigorating class natural Chinese medicine of health food, the dampness diuretic, the hidroschesis consolidating superficial resistance and in antiabortive effect; Ancient Chinese medicine is classified the Rhizoma Atractylodis Macrocephalae as on Chinese medicine product, antiabortive monarch drug, the panacea of fetus nourishing; The modern clinical cirrhotic ascites that are used for more, diarrhoea, Mo Niai syndrome, edema spontaneous perspiration, frequent fetal movement etc.; Modern pharmacological research confirms: 1, Rhizoma Atractylodis Macrocephalae Wheat Protein, can alleviate lipid peroxidation, and reduce the content of peroxide, avoid the destruction of harmful substance pair cell 26S Proteasome Structure and Function; And SOD activity improving trend is arranged, and enhancing body is to the ability of free radical scavenging, thus the damage of minimizing radical pair body.2, the Rhizoma Atractylodis Macrocephalae has delaying senility function, Rhizoma Atractylodis Macrocephalae decoct can improve the erythrocytic superoxide dismutase of aged mouse (SOD) activity, suppresses the brain activity of monoamine oxidase simultaneously, can also suppress erythrocytic autoxidation haemolysis, directly remove free radical, show anti-aging effects.3, the Rhizoma Atractylodis Macrocephalae has the enhance immunity effect, and oral lymhocyte transformation rate and the serum IgG content of making of Rhizoma Atractylodis Macrocephalae decoct significantly rises, and shows that the Rhizoma Atractylodis Macrocephalae has immunostimulation, and can strengthen the vigor of macrophage, strengthens the phagocytic function of reticuloendothelial system.4, anticancer tumor effect, Rhizoma Atractylodis Macrocephalae volatile oil has inhibitory action to murine sarcoma S180, and external have direct killing action to the ehrlich ascites tumor cell, and external the Eca109 esophageal cancer cell is presented inhibition, can make cell detachment, karyopycnosis, chromatin concentrates, and cell does not divide or seldom division.5, the Rhizoma Atractylodis Macrocephalae also has the blood lipid-reducing blood sugar-decreasing effect, antibacterial action, and blood coagulation resisting function promotes the brood weight increase, physical potentiation raises to can be made leukocyte count by the leukopenia that causes after chemotherapy or the radiotherapy tumor.Traditional Chinese medical science custom in prescription the compatibility Rhizoma Atractylodis Macrocephalae with the absorption, particularly compatibility gold that promote the medicine active ingredient, stone class medicine to promote the absorption and the utilization of mineral.
Radix Glehniae is a kind ofly can have nourishing YIN and moistening the lung, the effect of reinforcing stomach reg fluid as the nourishing YIN class natural Chinese medicine of health food.Be mainly used in lung-heat type cough, the few dry pharynx of expectorant, consumption of body fluid caused by febrile disease, dryness of the mouth and throat, dysphoria with smothery sensation is thirsty etc.Doctor trained in Western medicine is examined and is chronic bronchitis, bronchiectasis, pulmonary carcinoma, recurrent respiratory tract infection, cough during pregnancy, the pertussis person that belongs to the syndrome of yin deficiency due to lung heat, and diabetes spp is in lung-stomach yin deficiency card person.Modern pharmacological research confirms that Radix Glehniae has following pharmacological action: 1, tangible radiation resistance.2, stronger mutation inhibiting effect.3, antipyretic effect.4, sedation.5, the effect of anti-cyclophosphamide toxicity.
Vitamin B group participates in body internal protein, fat and sugar metabolism, makes the excitement of brain cell and inhibition be in poised state, and they coordinate the performance physiological action in human body.Vitamin B
1Have the effect of keeping the nervous system normal function, phenomenon such as it is incomplete to occur carbohydrate metabolism during shortage, and heat energy is under-supply, thus cause hypomnesis, influence the normal function of brain, if vitamin B
1Abundance can effectively form the energy of brain cell activity necessity, but improving memory, concentration power and learning capacity; Vitamin B in addition
1Suppress cholinesterase in addition, improve the function of cholinergic nerve; Vitamin B
2Be to keep skin and the requisite vitamin of eye health.Anemia of pregnant woman's vitamin B
2Lack or can not cause or inspire pregnant early pregnancy completely and vomit, second trimester angular cheilitis, glossitis, cheilitis and premature infant's incidence rate increase; Nicotiamide claims niacin amide or vitamin PP again; Its physiological function is to participate in the body intracellular metabolic, keeps normal neurological function, and pellagra can take place during shortage in synthesizing of assurance gonadal hormone etc., mainly shows as dermatitis, diarrhoea, dull-witted three big symptoms; Pantothenic acid extensively exists in each organism, participates in metabolic activity widely, and known have 70 plurality of enzymes all to need pantothenic acid to participate in all kinds of biochemical reaction of catalysis body, otherwise just can Metabolic disorder; Biotin also is a kind of vitamin B group, coordinates to participate in the metabolism of human body matter and energy with other vitamin B group, and it is synthetic with nucleic acid, and the compositive relation of gonadal hormone is close, and it also has control poliosis, bareheaded effect; Vitamin B
6Most important to the maincenter neurodevelopment, if shortage can make the nervus centralis hypoevolutism, intelligence descends, and it has the assistance vitamin B
1Effect, be the vitamin that can improve concentration power and stimulate desire learn; Vitamin B
12Participate in nucleic acid in vivo, choline, amino acid whose synthetic and fat and sugared metabolism, to hemopoietic function of bone marrow, the gastrointestinal epithelial cells function, liver function and nervous system myelin functional integrity have certain effect, it is the necessary vitamin of intelligence of bringing into normal play, not only cause dysnoesia if lack, also nutritional anemia can occur, influence is to blood supply in the brain; Folic acid participates in the synthetic of aminoacid and nucleic acid, and and vitamin B
12The common generation that promotes cell is with ripe, and normal cell can not carry out mitosis during shortage, the neurological symptom can occur, as: the loss of memory, depression and dementia etc.; Human body can be at vitamin B in addition
12Under the effect of folic acid as cofactors, by serine of taking in and the synthetic choline of methionine, choline is the key component of acetylcholine, and acetylcholine is an important neurotransmitter in the human body; Folic acid, vitamin B are arranged again
6And vitamin B
12Can work in coordination with and remove the intravital homotype cysteine of people, the homotype cysteine is a kind of neurotoxin, can cause the self murder of brain; There are some researches show that homocysteine is a kind of potential teratogen of independently growing, and is related closely with congenital heart disease and neural tube defects; Homocysteine also can cause miscarriage, premature labor in addition, clinical disastrous effect such as preeclampsia.
Vitamin D is the sterols derivant.The subcutaneous dehydrocholesterol of human body produces vitamin D through ultraviolet radiation
3, ergosterol produces vitamin D behind ultraviolet radiation
2, the two originates different, the function unanimity, and the importance of vitamin D is to regulate the metabolism of calcium and phosphorus in human nutrition; Vitamin D promotes calcium in little intestinal absorption, the then a large amount of calcium of the D that is deficient in vitamin are discharged by feces, thereby cause the human body calcium deficiency, and rickets can take place the child, become the calcium phosphorus of storing in the human body to exhaust and can cause osteomalacia, modal osteomalacia crowd is anemia of pregnant woman, wet nurse and old people.
Calcium is the macroelement that body weight for humans is wanted, and mainly plays two aspects, the one, constitute sclerous tissueses such as bone tooth; The 2nd, constitute the material of specific function with protein bound or with the form of calcium ion, form in so-called miscible calcium pool and the bone tooth calcium and keep dynamic equilibrium, all cells all need its normal function of calcium competence exertion in the body; Anemia of pregnant woman and wet nurse's calcium deficiency can influence the growth of its body constitution and fetus or infant; Calcium deficiency can cause that also endocrine dysfunction and cell cycle regulation are malfunctioning; And anemia of pregnant woman and wet nurse are owing to physiological characteristics, the Deficiency of Intake of ubiquity calcium.
Magnesium topmost function in human body is the generation of containment free radical, and free radical is short old and feeble factor, also is the factor that mainly causes birth defect; Another function of magnesium is to bring into play the effect of protection skeleton with calcium and vitamin D, and osteoporosis takes place magnesium deficiency easily, fractures easily; Magnesium is protected heart in addition and is prevented and treated the function etc. of diabetes in addition.
Trace element zinc is merged in the biomacromolecule ligand---in protein, nucleic acid, the film (being mainly memebrane protein), generate stable metallic biomacromolecule complex---metalloprotein, metalloproteinase nucleic acid complex etc., at present, known these materials participate in the synthetic and degradation process of carbohydrate, lipid, protein and nucleic acid; The existence of zinc enzyme is all arranged in six big fermentoids; Zinc also is the essential element of enhance immunity vigor; Zinc can promote that proinsulin is converted into insulin by activating protaminase.Zinc deficiency makes insulin be obstructed in the activity of peripheral tissues, and it is unusual to cause glucose tolerance curve; Anemia of pregnant woman's zinc deficiency can influence the growth promoter of fetus to some extent, so that causes all deformities of fetus; Zinc deficiency can cause brain development bad, incomplete development of mind.
Trace element-selenium has obvious reduction serum total cholesterol, triglyceride and lipid peroxide, improves high density lipoprotein, the metabolic effect of superabundant fats in the acceleration bodies; Selenium also has the strong anti-oxidation function, and the protection embryo is not subjected to the injury of superoxides, prevention of cardiac; Anticancer by enhance immunity recognition system removing cancerous cell; Remove and the drainage heavy metal ion, hydrargyrum, methyl mercury, cadmium, lead etc. are had Detoxication, and heavy metal pollution is mainly to cause the birth defect factor; Scarce selenium can make the human insulin secretion reduce, impaired glucose tolerance, and oxidation resistance descends and quickens human senility and intelligence decline.
The major physiological function of trace elements iron is as hemoglobin, Myoglobin, and the ingredient of cytochrome etc. participates in transporting and the Tissue respiration process of the interior oxygen of body; In the conveying of oxygen and electronics, play central role; Contain ferrum in the catalatic structure, and hydrogen peroxide relies on catalatic degraded; Hydrogen peroxide is a free radical the most dangerous in the human body, and iron deficiency is common in infant, anemia of pregnant woman and wet nurse, causes iron deficiency anemia, and its cardinal symptom is to have a delicate constitution, and memory weakens, and ability to work descends; Iron deficiency also can exert an influence to other system of human body; As the nervous system iron deficiency, can affect the nerves conduction and make the child occur that intelligence reduces and behavior disorder.
Application contains the Rhizoma Atractylodis Macrocephalae, Radix Glehniae, vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin D and macroelement calcium, magnesium and trace element zinc, selenium, ferrum has been known as the compositions of active component, but with the Rhizoma Atractylodis Macrocephalae, Radix Glehniae, vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid,, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin D and macroelement calcium, magnesium and trace element zinc, selenium, ferrum compatibility be used to prevent birth defect and the pharmaceutical composition that improves memory report as yet.
Current medicine that is used to improve memory or health food kind have multiple, but aim at pregnant before the medicine or the health food that are used to improve memory of women, anemia of pregnant woman, wet nurse's development do not see as yet; Do not see the medicine label that is used to prevent birth defect as yet, rarely seen report that folic acid prevention neural tube defects is arranged; But its target spot is few, and the link shortcoming needs perfect.And will prevent the effect of birth defect and improvement memory and be used for same medicine person not see as yet.
Summary of the invention:
In order to overcome existing prevention birth defect and/or to improve the shortcoming and defect of memory medicine, the purpose of this invention is to provide a kind of compositions, said composition promotes the absorption and the utilization of vitamin, mineral by the Rhizoma Atractylodis Macrocephalae, and with the collaborative vitamin B that strengthens of Radix Glehniae
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin D, macroelement calcium, magnesium and trace element zinc, selenium, ferrum, prevent the effect of birth defect and improvement memory, pass through the effect of macroelement calcium, magnesium and trace element zinc, selenium, ferrum, compound vitamin B, vitamin D, increase Rhizoma Atractylodis Macrocephalae defying age, antioxidation and Radix Glehniae radioprotective, mutation inhibiting simultaneously; Even chronic administration is also without any side effect.Because the result of broad research, the inventor has found the Rhizoma Atractylodis Macrocephalae, Radix Glehniae, vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin D and macroelement calcium, magnesium and trace element zinc, selenium, ferrum novel combination, this novel combination for the prevention birth defect with improve memory synergy arranged; And single with the Rhizoma Atractylodis Macrocephalae, Radix Glehniae, compound vitamin B, vitamin D and macroelement calcium, magnesium and trace element zinc, selenium, ferrum, its effect is all not as good as this compositions; And the effective ingredient of each component has the addition complementary action to the health care tonification of human body, as the Rhizoma Atractylodis Macrocephalae of the used dosage of this compositions antiabortive, the defying age of fetus nourishing, enhance immunity, the effect of physical strength reinforcing is arranged; Radix Glehniae has effects such as nourishing YIN and moistening the lung, reinforcing stomach reg fluid, radioprotective, mutation inhibiting; Trace element zinc is the necessary material of zinc enzyme in the interior six big fermentoids of human body, also is the essential element of enhance immunity vigor; But the metabolism of superabundant fats has the strong anti-oxidation function, prevention of cardiac function, anti-cancer function etc. in the trace element-selenium acceleration bodies; Trace elements iron participates in transporting and the Tissue respiration process of the interior oxygen of body, is the only element that prevents iron deficiency anemia; Vitamin B and for example
1Can prevent and treat vitamin B1 deficiency, keep the normal activity of nerve, digestion, muscle, blood circulation; Vitamin B
2Be to keep skin and the requisite vitamin of eye health; Pellagra can take place in nicotinamide deficiency; The pantothenic acid shortage can cause Metabolic disorder; Biotin can be prevented and treated poliosis, bald head; Vitamin B
6Can eliminate intraepithelial neoplasia cells, raise immunity, the protection blood vessel; Vitamin B
12Be used for various megaloblastic anemias and neural disease; Folic acid is protected heart and antitumaous effect in addition; Macroelement calcium, magnesium and vitamin D are brought into play the effect of protection skeleton jointly.There is not incompatibility in this compositions, have no side effect, and cost is low, thereby constitutes the present invention.
The invention provides the compositions that is used to prevent birth defect and improves memory, it comprises the Rhizoma Atractylodis Macrocephalae, Radix Glehniae, vitamin B as active component
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin D and macroelement calcium, magnesium and trace element zinc, selenium, ferrum.
The Rhizoma Atractylodis Macrocephalae is the Compositae herbaceos perennial Rhizoma Atractylodis Macrocephalae (Atractylodes macrocephala koidz) rhizome.Main product in Zhejiang, ground such as Hubei, Hunan.Gather winter, dries or dry, and life usefulness or parching with earth, parched with bran are used.The used Rhizoma Atractylodis Macrocephalae of the present invention can be with its extract as raw material.
Radix Glehniae is the root of Umbelliferae herbaceos perennial glehnia littoralis Clehnia littoralis Fr.Schmidt ex Miq..The surface is white in color, and that is suitable for that sand ground growth, forefathers think effectiveness extensively is similar to the ginseng class.Mainly be distributed in coastal provinces, main product Yushan Hill Dongguo sun, Yantai, Wendeng City, umbrella are flat, Peng Lai, Laoshan, Qinhuangdao, Hebei, Ding County, Anguo, Lianyun Harbour, Jiangsu, ground such as Lvshun, Liaoning, Dalian.With Laiyang, Shandong Hu Chengcun product for the most famous.Wild and cultivation product all have, but see with the cultivation mouth more.With elongated, cylindrical, the even matter heavily fortified point of branch, the fair and clear person of outer color of the leather is good.
Be used for vitamin B of the present invention
1(VitaminB
1), vitamin B
2(VitaminB
2), nicotiamide (Nicotinamide), pantothenic acid (Pantothenic Acid), biotin (Vitamin H), vitamin B
6(VitaminB
6), vitamin B
12(VitaminB
12), folic acid (Folic Acid), all are water soluble vitamins, do not accumulate in vivo; Vitamin D (VitaminD) is a fatsoluble vitamin, and is useful and harmless by the used dosage of the present invention; Zinc (Zn), selenium (Se), ferrum (Fe) are micro elements needed by human, and calcium (Ca), magnesium (Mg) are the macroelements of needed by human; Wherein macroelement calcium can be selected calcium gluconate, calcium lactate, calcium carbonate etc. for use, macroelement magnesium can be selected magnesium chloride, magnesium gluconate, magnesium lactate, magnesium carbonate etc. for use, trace element zinc can be selected zinc citrate, zinc gluconate, single zinc methionine etc. for use, trace element-selenium can be selected Selenomethionine, methoxybenzyl cyanic acid selenium, the two cyanic acid selenium of phenylene, sodium selenite, sodium selenate etc. for use, trace elements iron can be selected Ferrous gluconate, ferrous lactate, ferrous sulfate etc. for use, and professional production factory and supplier are all arranged.
Compositions of the present invention mainly is applicable to women in pregnant early stage, anemia of pregnant woman and wet nurse; Be subjected to the influence of factors such as geology, food chain, dietetic life custom, the effective dose that the each department crowd that benefits from benefits from this compositions each component has certain difference; By the present invention, the effective dose of Rhizoma Atractylodis Macrocephalae extract is counted 500-15000mg/ days with whole crude drug, and the effective dose of Radix glehniae extract is counted 300-12000mg/ days with whole crude drug, vitamin B
1Effective dose be 0.5-20mg/ days, vitamin B
2Effective dose be 0.5-20mg/ days, the effective dose of nicotiamide is 5-50mg/ days, the effective dose of pantothenic acid is 2-20mg/ days, the effective dose of biotin is 0.01-0.1mg/ days, vitamin B
6Effective dose be 0.5-10mg/ days, vitamin B
12Effective dose be 0.001-0.025mg/ days, the effective dose of folic acid is 0.1-1mg/ days, the effective dose of vitamin D is 0.0015-0.01mg/ days, the effective dose of macroelement calcium is 250-1000mg/ days, the effective dose of magnesium is 100-300mg/ days, the effective dose of trace element zinc is 5-20mg/ days, and selenic effective dose is 0.015-0.1mg/ days, and the effective dose of ferrum is 5-20mg/ days.
Compositions of the present invention can or directly be taken by following pharmaceutical dosage forms dispenser, for example, oral formulations is (as granule, powder, capsule, ball, sheet, dry syrup, liquid formulation), or food such as food (as cookies), mix and prepare with other known additives, this class additive is for example: carrier, disintegrating agent, slow releasing agent, excipient, filler, covering, binding agent, lubricant, antioxidant, apply agent, coloring agent, correctives, sweeting agent, sucrose succedaneum, nutrition enhancer, synergist, short absorbent, flavouring agent, surfactant, plasticizer, the PH regulator, freshener, suspending agent, defoamer, antiseptic, thickening agent, solubilisation aids etc. are prepared or they are added food as functional component or additive by usual way.
By the present invention, the Rhizoma Atractylodis Macrocephalae, Radix Glehniae, vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin D and macroelement calcium, magnesium and trace element zinc, selenium, ferrum each component can distinguish preparation, the preparation of each component can be mixed the back when using and use or do not mix simultaneously and use.
Advantage of the present invention is that this compositions is eliminated the multiple factor that causes birth defect and cause hypomnesis from too many levels, multisystem, many target spots, the effect of collaborative performance effect is arranged between the each component, prevention birth defect and improvement memory there is significant effect, sufficient raw, cost is low, and each component has no side effect in the compositions, no incompatibility, except that prevention birth defect and improvement memory, human body still there is the health care benefiting action.
Subordinate list 1 is this compositions and the Rhizoma Atractylodis Macrocephalae and Radix Glehniae component and the young rat/mouse labyrinth test effect comparison of vitamin added elements component.
Subordinate list 2 is this compositions and the Rhizoma Atractylodis Macrocephalae and Radix Glehniae component and the comparison of vitamin added elements component Aged Mice maze test effect.
Relatively tabulate below with reference to embodiment and test implementation example effect and to be described in detail the present invention.
Embodiment 1
Rhizoma Atractylodis Macrocephalae 2000mg,
Radix Glehniae 500mg,
Folic acid 0.4mg,
Vitamin B
62mg,
Vitamin B
120.003mg,
Zinc citrate (in trace element zinc) 10mg,
Sodium selenite (in trace element-selenium) 0.03mg,
Ferrous sulfate (in trace elements iron) 10mg,
Calcium lactate (in element calcium) 500mg,
Vitamin D 0.002mg.
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 2
Rhizoma Atractylodis Macrocephalae 2000mg,
Radix Glehniae 500mg,
Folic acid 0.4mg,
Vitamin B
62mg,
Vitamin B
120.003mg,
Zinc citrate (in trace element zinc) 10mg,
Sodium selenite (in trace element-selenium) 0.03mg,
Ferrous sulfate (in trace elements iron) 10mg,
Calcium lactate (in element calcium) 500mg,
Magnesium lactate (in element magnesium) 200mg,
Vitamin D 0.002mg.
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 3
Rhizoma Atractylodis Macrocephalae 2000mg,
Radix Glehniae 500mg,
Folic acid 0.4mg,
Vitamin B
62mg,
Vitamin B
120.003mg,
Vitamin B
13mg,
Vitamin B
23mg,
Nicotiamide 10mg,
Zinc citrate (in trace element zinc) 10mg,
Sodium selenite (in trace element-selenium) 0.03mg,
Ferrous sulfate (in trace elements iron) 10mg,
Calcium lactate (in element calcium) 500mg,
Vitamin D 0.002mg.
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 4
Rhizoma Atractylodis Macrocephalae 2000mg,
Radix Glehniae 500mg,
Folic acid 0.4mg,
Vitamin B
62mg,
Vitamin B
120.003mg,
Vitamin B
13mg,
Vitamin B
23mg,
Nicotiamide 10mg,
Zinc citrate (in trace element zinc) 10mg,
Sodium selenite (in trace element-selenium) 0.03mg,
Ferrous sulfate (in trace elements iron) 10mg,
Calcium lactate (in element calcium) 500mg,
Magnesium lactate (in element magnesium) 200mg,
Vitamin D 0.002mg.
Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, again the gained mixture is made 3 bag shot-like particles.Obey every day 3 times, obey a bag at every turn.
Embodiment 5
Rhizoma Atractylodis Macrocephalae 2000mg,
Radix Glehniae 500mg,
Folic acid 0.4mg,
Vitamin B
62mg,
Vitamin B
120.003mg,
Vitamin B
13mg,
Vitamin B
23mg,
Nicotiamide 10mg,
Pantothenic acid 5mg,
Biotin 0.05mg,
Zinc citrate (in trace element zinc) 10mg,
Sodium selenite (in trace element-selenium) 0.03mg,
Ferrous sulfate (in trace elements iron) 10mg,
Calcium lactate (in element calcium) 500mg,
Magnesium lactate (in element magnesium) 200mg,
Vitamin D 0.002mg.
Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, again the gained mixture is made 3 bag shot-like particles.Obey every day 3 times, obey a bag at every turn.
Confirm that through animal experiment this compositions belongs to nontoxic level; The crowd takes and does not also see toxicity.
Subordinate list 1: the young rat/mouse labyrinth test effect of this compositions and the Rhizoma Atractylodis Macrocephalae and Radix Glehniae component and vitamin added elements component compares:
| Group | Medicine | Consumption | Sample number | The mistake percentage rate |
| The A group | Matched group | 0 | 12 | 21.6％ |
| The B group | The Rhizoma Atractylodis Macrocephalae and Radix Glehniae group | Rhizoma Atractylodis Macrocephalae 100mg+ Radix Glehniae 50mg/ days | 12 | 19％ |
| The C group | Element+vitamin group | Calcium 8mg+ magnesium 3mg+ zinc 0.1mg+ ferrum 0.1mg+ selenium 0.001mg+ VB 10.1mg+VB 20.1mg+ nicotiamide 0.2mg+ pantothenic acid 0.1mg+ biotin 0.001mg+VB 60.08mg +VB 120.0001mg+ folic acid 0.008mg+VD0.0001mg/ days | 12 | 18.2％ |
| The D group | The Rhizoma Atractylodis Macrocephalae and Radix Glehniae group+vitamin+element set | Rhizoma Atractylodis Macrocephalae 100mg+ Radix Glehniae 50mg calcium 8mg+ magnesium 3mg+ zinc 0.1mg+ ferrum 0.1mg+ selenium 0.001mg+ VB 10.1mg+VB 20.1mg+ nicotiamide 0.2mg+ pantothenic acid 0.1mg+ biotin 0.001mg+VB 60.08mg +VB 120.0001mg+ folic acid 0.008mg+VD0.0001mg/ days | 12 | 17％ |
Subordinate list 2: this compositions and the Rhizoma Atractylodis Macrocephalae and Radix Glehniae component and vitamin added elements component Aged Mice maze test effect compare:
| Group | Medicine | Consumption | Sample number | The mistake percentage rate |
| The A group | Matched group | 0 | 12 | 53.3％ |
| The B group | The Rhizoma Atractylodis Macrocephalae and Radix Glehniae group | Rhizoma Atractylodis Macrocephalae 100mg+ Radix Glehniae 50mg/ days | 12 | 35.1％ |
| The C group | Element+vitamin group | Calcium 8mg+ magnesium 3mg+ zinc 0.1mg+ ferrum 0.1mg+ selenium 0.001mg+ VB 10.1mg+VB 20.1mg+ nicotiamide 0.2mg+ pantothenic acid 0.1mg+ biotin 0.001mg+VB 60.08mg +VB 120.0001mg+ folic acid 0.008mg+VD0.0001mg/ days | 12 | 31.6％ |
| The D group | The Rhizoma Atractylodis Macrocephalae and Radix Glehniae+vitamin+element set | Rhizoma Atractylodis Macrocephalae 100mg+ Radix Glehniae 50mg+ calcium 8mg+ magnesium 3mg+ zinc 0.1mg+ ferrum 0.1mg+ selenium 0.001mg+ VB 10.1mg+VB 20.1mg+ nicotiamide 0.2mg+ pantothenic acid 0.1mg+ biotin 0.001mg+VB 60.08mg +VB 120.0001mg+ folic acid 0.008mg+VD0.0001mg/ days | 12 | 30.2％ |
Annotate: each group was tested by dosage feed in the table respectively in 60 days in subordinate list 1, the subordinate list 2; Consumption converts by per kilogram of body weight in the table; Zinc, selenium, ferrum are in trace element, and calcium, magnesium are in element.
Select 50 of newly-married healthy womens, 25 years old mean age, take this compositions continuously from beginning in pregnant preceding 3 months, followed up a case by regular visits to none routine birth defect in 6 months to the baby due.With associated materials statistics contrasts, birth defect youngster accounts for the 4-6% of newborn population sum, and there were significant differences.
Can obviously find out from table 1, table 2, this compositions is by Rhizoma Atractylodis Macrocephalae component in rat/mouse labyrinth test and the compositions and the contrast of vitamin added elements component, the statistical result of mistake percentage rate, the function of this composition for improved memory is better than Rhizoma Atractylodis Macrocephalae component or vitamin added elements component; With the blank group significant difference is arranged relatively.
Claims (5)
1, a kind of pharmaceutical composition that is used to prevent birth defect and improves memory is characterized in that it is made by weight ratio by following raw materials according:
Rhizoma Atractylodis Macrocephalae 500-15000mg,
Radix Glehniae 300-12000mg,
Folic acid 0.1-1mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Vitamin B
10-20mg,
Vitamin B
20-20mg,
Nicotiamide 0-50mg,
Pantothenic acid 0-20mg,
Biotin 0-0.1mg,
Zinc 5-20mg,
Selenium 0.015-0.1mg,
Ferrum 5-20mg,
Magnesium 0-300mg,
Calcium 250-1000mg,
Vitamin D 0.0015-0.01mg.
2, the pharmaceutical composition that is used to prevent birth defect and improves memory according to claim 1 is characterized in that it is made by weight ratio by following raw materials according:
Rhizoma Atractylodis Macrocephalae 500-15000mg,
Radix Glehniae 300-12000mg,
Folic acid 0.1-1mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Vitamin B
10-20mg,
Vitamin B
20-20mg,
Nicotiamide 0-50mg,
Pantothenic acid 0-20mg,
Biotin 0-0.1mg,
Zinc 5-20mg,
Selenium 0.015-0.1mg,
Ferrum 5-20mg,
Magnesium 100-300mg,
Calcium 250-1000mg,
Vitamin D 0.0015-0.01mg.
3, the pharmaceutical composition that is used to prevent birth defect and improves memory according to claim 1 is characterized in that it is made by weight ratio by following raw materials according:
Rhizoma Atractylodis Macrocephalae 500-15000mg,
Radix Glehniae 300-12000mg,
Folic acid 0.1-1mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Vitamin B
10.5-20mg,
Vitamin B
20.5-20mg,
Nicotiamide 5-50mg,
Pantothenic acid 0-20mg,
Biotin 0-0.1mg,
Zinc 5-20mg,
Selenium 0.015-0.1mg,
Ferrum 5-20mg,
Magnesium 0-300mg,
Calcium 250-1000mg,
Vitamin D 0.0015-0.01mg.
4, the pharmaceutical composition that is used to prevent birth defect and improves memory according to claim 1 is characterized in that it is made by weight ratio by following raw materials according:
Rhizoma Atractylodis Macrocephalae 500-15000mg,
Radix Glehniae 300-12000mg,
Folic acid 0.1-1mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Vitamin B
10.5-20mg,
Vitamin B
20.5-20mg,
Nicotiamide 5-50mg,
Pantothenic acid 0-20mg,
Biotin 0-0.1mg,
Zinc 5-20mg,
Selenium 0.015-0.1mg,
Ferrum 5-20mg,
Magnesium 100-300mg,
Calcium 250-1000mg,
Vitamin D 0.0015-0.01mg.
5, the pharmaceutical composition that is used to prevent birth defect and improves memory according to claim 1 is characterized in that it is made by weight ratio by following raw materials according:
Rhizoma Atractylodis Macrocephalae 500-15000mg,
Radix Glehniae 300-12000mg,
Folic acid 0.1-1mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Vitamin B
10.5-20mg,
Vitamin B
20.5-20mg,
Nicotiamide 5-50mg,
Pantothenic acid 2-20mg,
Biotin 0.01-0.1mg,
Zinc 5-20mg,
Selenium 0.015-0.1mg,
Ferrum 5-20mg,
Magnesium 100-300mg,
Calcium 250-1000mg,
Vitamin D 0.0015-0.01mg.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101139618A CN101297838A (en) | 2008-05-29 | 2008-05-29 | Pharmaceutical combination for preventing birth-defect and improving memory |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101139618A CN101297838A (en) | 2008-05-29 | 2008-05-29 | Pharmaceutical combination for preventing birth-defect and improving memory |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101297838A true CN101297838A (en) | 2008-11-05 |
Family
ID=40077873
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2008101139618A Pending CN101297838A (en) | 2008-05-29 | 2008-05-29 | Pharmaceutical combination for preventing birth-defect and improving memory |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101297838A (en) |
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2008
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