CN101293116A - Absorbent bone interface screw nail and preparation method thereof - Google Patents
Absorbent bone interface screw nail and preparation method thereof Download PDFInfo
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- CN101293116A CN101293116A CNA2008100624851A CN200810062485A CN101293116A CN 101293116 A CN101293116 A CN 101293116A CN A2008100624851 A CNA2008100624851 A CN A2008100624851A CN 200810062485 A CN200810062485 A CN 200810062485A CN 101293116 A CN101293116 A CN 101293116A
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- tricalcium phosphate
- bone interface
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- nanometer beta
- interface screw
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Abstract
The present invention discloses an absorbable bone interface screw and a preparation method thereof. The bone interface screw contains 5 to 40 percent of nanometer beta-tertiary calcium phosphate and 95 to 60 percent of polylactic acid by weight percentage. Nanometer beta-tertiary calcium phosphate powder is mixed with polylactic acid by solution; flow casting rapid drying method is adopted to evenly distribute the nanometer beta-tertiary calcium phosphate in the polymer matrix, thus molding in an injection machine. The bone interface screw provided by the present invention has the advantages of good biological activity and degradability, as well as very large specific surface area and high intensity.
Description
Technical field
The invention belongs to composite that bone and tendon repair use and preparation method thereof, particularly relate to a kind of absorbable nanometer beta-tricalcium phosphate and strengthen bone interface screw and preparation method thereof.
Background technology
The bone interface screw is used on flesh key and the bone.Adopt metal material to manufacture traditionally.Adopt in recent years or interference screw that degradation of polymer material is manufactured increases gradually, its maximum characteristics are can degrade behind the implant into body, along with the healing of tissue, implant is slowly degraded, after the organization healing, implant is inhaled ashamed fully, thereby does not want second operation.But this interference screw is along with the increase of degradation time, and mechanical properties decrease is too fast; The acidic materials that produce in degradation process can cause tissue to produce the aseptic inflammation reaction, influence tissue repair.Introduce calcium phosphate material therein and can effectively improve these problems: calcium phosphate/lactic acid composite material interference screw intensity improves, and since calcium phosphate have with skeleton in inorganic mutually similar chemical composition, thereby make screw have good biological activity and bone conductibility.But, have Different Ca/P than different with the degradation rate of the calcium phosphate of crystalline phase and degree of crystallinity, wherein the beta-tricalcium phosphate be generally acknowledge have a kind of of good degradability.
Chinese patent (CN1403167) and United States Patent (USP) (US5981619) disclose calcium phosphate added and have obtained mechanical property composite preferably in the polymer.But the particle size of the calcium phosphate in these composites bigger (about 1～100 μ m), the degradation property of composite is good inadequately.
Summary of the invention
The object of the present invention is to provide a kind of high-intensity absorbent bone interface screw nail and preparation method thereof.
Absorbent bone interface screw nail of the present invention, it contains mass percent and is: 5～40% nanometer beta-tricalcium phosphate, 95～60% polylactic acid.
The size of above-mentioned nanometer beta-tricalcium phosphate is 50～800nm.Polylactic acid is a mean molecule quantity in 100,000～1,200,000 Poly-L-lactic acid (PLLA) or dextrorotation polylactic acid (PDLA) or PDLLA (PDLLA).
The preparation method of absorbent bone interface screw nail may further comprise the steps:
1) under 20 ℃～80 ℃ polylactic acid is dissolved in the organic solvent dioxane, forming concentration is the solution A of 5%～10% grams per milliliter;
2) nanometer beta-tricalcium phosphate is joined in the stearic acid alcoholic solution that concentration is 10%～30% grams per milliliter, the concentration of nanometer beta-tricalcium phosphate in the stearic acid alcoholic solution is 1%～15% grams per milliliter, handled 10～600 minutes down at 20 ℃～75 ℃, leach powder, drying, the nanometer beta-tricalcium phosphate of formation surface modification;
3) the nanometer beta-tricalcium phosphate of surface modification is joined in the solution A that step 1) makes, through stirring and ultra-sonic dispersion formation suspension B;
4) with The tape casting the suspension B of step 3) is prepared into the thin slice that thickness is 1～5mm, dry down at 40 ℃～130 ℃, be ground into bulk goods then, add to and also inject the die for molding with required screw form in the injection machine, forming temperature is 100 ℃～190 ℃.
Beneficial effect of the present invention is:
This interference screw adopted nanometer beta-tricalcium phosphate powder and polylactic acid compound, with solution mixing and curtain coating rapid dry process nanometer beta-tricalcium phosphate powder is dispersed in the polymeric matrix, nano level beta-tricalcium phosphate also has very large specific surface area when having good biological activity and degradability, not only can strengthen the degradability of nail, can also increase the intensity of bone interface screw.
The specific embodiment
Embodiment 1
1) under 50 ℃ the 2.0g mean molecule quantity is being dissolved in 20 milliliters of dioxane in 200,000 Poly-L-lactic acid, forming concentration is the solution A of 10% grams per milliliter;
2) be that the beta-tricalcium phosphate of 50 nanometers joins in 10 milliliters of stearic acid alcoholic solution that concentration is 20% grams per milliliter with the 0.5g particle diameter, the concentration of nanometer beta-tricalcium phosphate in the stearic acid alcoholic solution is 5% grams per milliliter, handled 50 minutes down at 50 ℃, leach powder, drying, the nanometer beta-tricalcium phosphate of formation surface modification;
3) the nanometer beta-tricalcium phosphate of surface modification is joined in the solution A that step 1) makes, through stirring and ultra-sonic dispersion formation suspension B;
4) with The tape casting the suspension B of step 3) is prepared into the thin slice that thickness is 1mm, 40 ℃ of dryings, is ground into bulk goods then, add in the injection machine and inject the die for molding with required screw form, forming temperature is 100 ℃.Promptly get the bone interface screw of the beta-tricalcium phosphate that contains mass percent 20%, its bending strength is 160MPa.
Embodiment 2
1) under 60 ℃ the 2.0g mean molecule quantity is being dissolved in 20 milliliters of dioxane at 100,000 dextrorotation polylactic acid, forming concentration is the solution A of 10% grams per milliliter;
2) be that the beta-tricalcium phosphate of 100 nanometers joins in 10 milliliters of stearic acid alcoholic solution that concentration is 10% grams per milliliter with the 0.11g particle diameter, the concentration of nanometer beta-tricalcium phosphate in the stearic acid alcoholic solution is 1.1% grams per milliliter, handled 10 minutes down at 75 ℃, leach powder, drying, the nanometer beta-tricalcium phosphate of formation surface modification;
3) the nanometer beta-tricalcium phosphate of surface modification is joined in the solution A that step 1) makes, through stirring and ultra-sonic dispersion formation suspension B;
4) with The tape casting the suspension B of step 3) is prepared into the thin slice that thickness is 2mm, 100 ℃ of dryings, is ground into bulk goods then, add in the injection machine and inject the die for molding with required screw form, forming temperature is 190 ℃.Promptly get the bone interface screw of the beta-tricalcium phosphate that contains mass percent 5%, its bending strength is 138MPa.
Embodiment 3
1) under 20 ℃ the 2.0g mean molecule quantity is being dissolved in 40 milliliters of dioxane in 1,200,000 PDLLA, forming concentration is the solution A of 5% grams per milliliter;
2) be that the beta-tricalcium phosphate of 800 nanometers joins in 10 milliliters of stearic acid alcoholic solution that concentration is 15% grams per milliliter with the 1.33g particle diameter, the concentration of nanometer beta-tricalcium phosphate in the stearic acid alcoholic solution is 13.3% grams per milliliter, handled 600 minutes down at 20 ℃, leach powder, drying, the nanometer beta-tricalcium phosphate of formation surface modification;
3) the nanometer beta-tricalcium phosphate of surface modification is joined in the solution A that step 1) makes, through stirring and ultra-sonic dispersion formation suspension B;
4) with The tape casting the suspension B of step 3) is prepared into the thin slice that thickness is 5mm, 130 ℃ of dryings, is ground into bulk goods then, add in the injection machine and inject the die for molding with required screw form, forming temperature is 150 ℃.Promptly get the bone interface screw of the beta-tricalcium phosphate that contains mass percent 40%, its bending strength is 195MPa.
Embodiment 4
1) under 80 ℃ the 2.0g mean molecule quantity is being dissolved in 25 milliliters of dioxane in 600,000 Poly-L-lactic acid, forming concentration is the solution A of 8% grams per milliliter;
2) be that the beta-tricalcium phosphate of 300 nanometers joins in 10 milliliters of stearic acid alcoholic solution that concentration is 20% grams per milliliter with the 0.5g particle diameter, the concentration of nanometer beta-tricalcium phosphate in the stearic acid alcoholic solution is 5% grams per milliliter, handled 120 minutes down at 50 ℃, leach powder, drying, the nanometer beta-tricalcium phosphate of formation surface modification;
3) the nanometer beta-tricalcium phosphate of surface modification is joined in the solution A that step 1) makes, through stirring and ultra-sonic dispersion formation suspension B;
4) with The tape casting the suspension B of step 3) is prepared into the thin slice that thickness is 3mm, 80 ℃ of dryings, is ground into bulk goods then, add in the injection machine and inject the die for molding with required screw form, forming temperature is 160 ℃.Promptly get the bone interface screw of the beta-tricalcium phosphate that contains mass percent 20%, its bending strength is 179MPa.
Claims (4)
1. absorbent bone interface screw nail is characterized in that it contains mass percent and be: 5～40% nanometer beta-tricalcium phosphate, 95～60% polylactic acid.
2. absorbent bone interface screw nail according to claim 1, the size that it is characterized in that nanometer beta-tricalcium phosphate is 50～800nm.
3. absorbent bone interface screw nail according to claim 1 is characterized in that said polylactic acid is a mean molecule quantity in 100,000～1,200,000 Poly-L-lactic acid or dextrorotation polylactic acid or PDLLA.
4. the preparation method of absorbent bone interface screw nail according to claim 1 is characterized in that may further comprise the steps:
1) under 20 ℃～80 ℃ polylactic acid is dissolved in the organic solvent dioxane, forming concentration is the solution A of 5%～10% grams per milliliter;
2) nanometer beta-tricalcium phosphate is joined in the stearic acid alcoholic solution that concentration is 10%～30% grams per milliliter, the concentration of nanometer beta-tricalcium phosphate in the stearic acid alcoholic solution is 1%～15% grams per milliliter, handled 10～600 minutes down at 20 ℃～75 ℃, leach powder, drying, the nanometer beta-tricalcium phosphate of formation surface modification;
3) the nanometer beta-tricalcium phosphate of surface modification is joined in the solution A that step 1) makes, through stirring and ultra-sonic dispersion formation suspension B;
4) with The tape casting the suspension B of step 3) is prepared into the thin slice that thickness is 1～5mm, dry down at 40 ℃～130 ℃, be ground into bulk goods then, add to and also inject the die for molding with required screw form in the injection machine, forming temperature is 100 ℃～190 ℃.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100624851A CN101293116A (en) | 2008-06-12 | 2008-06-12 | Absorbent bone interface screw nail and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100624851A CN101293116A (en) | 2008-06-12 | 2008-06-12 | Absorbent bone interface screw nail and preparation method thereof |
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| CN101293116A true CN101293116A (en) | 2008-10-29 |
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| CNA2008100624851A Pending CN101293116A (en) | 2008-06-12 | 2008-06-12 | Absorbent bone interface screw nail and preparation method thereof |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102247624A (en) * | 2011-01-21 | 2011-11-23 | 北京中奥汇成生物材料科技有限公司 | Absorbable bone screw and preparation method thereof |
| CN102490308A (en) * | 2011-12-26 | 2012-06-13 | 华东理工大学 | Preparation method of absorbent composite internal fixator |
| CN102698321A (en) * | 2012-06-29 | 2012-10-03 | 上海大学 | Preparation method of bone repairing body with drug loading function |
| CN102940910A (en) * | 2012-12-07 | 2013-02-27 | 北京中奥汇成生物材料科技有限公司 | Absorbable bone screw as well as preparation method and application of absorbable bone screw |
| CN103585678A (en) * | 2013-11-14 | 2014-02-19 | 中山大学 | Casein-calcium carbonate microsphere modified polylactic acid membrane material as well as preparation method and application thereof |
| CN104436321A (en) * | 2014-12-25 | 2015-03-25 | 长春圣博玛生物材料有限公司 | Anchorage nail and preparation method thereof |
| CN104984414A (en) * | 2015-07-29 | 2015-10-21 | 陕西博与再生医学有限公司 | Composite absorbable interface screw and preparation method thereof |
| CN105268033A (en) * | 2015-11-06 | 2016-01-27 | 杭州锐健马斯汀医疗器材有限公司 | Absorbable reticular reinforced interface screw and preparation method thereof |
| CN110051888A (en) * | 2019-04-12 | 2019-07-26 | 杭州锐健马斯汀医疗器材有限公司 | One kind absorbable compound interface screw sheath flexible and preparation method thereof |
| CN111359025A (en) * | 2020-04-15 | 2020-07-03 | 花沐医疗科技(上海)有限公司 | Orderly-absorbed composite absorbable interface screw system with sheath and preparation method thereof |
-
2008
- 2008-06-12 CN CNA2008100624851A patent/CN101293116A/en active Pending
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102247624A (en) * | 2011-01-21 | 2011-11-23 | 北京中奥汇成生物材料科技有限公司 | Absorbable bone screw and preparation method thereof |
| CN102490308A (en) * | 2011-12-26 | 2012-06-13 | 华东理工大学 | Preparation method of absorbent composite internal fixator |
| CN102698321A (en) * | 2012-06-29 | 2012-10-03 | 上海大学 | Preparation method of bone repairing body with drug loading function |
| CN102940910A (en) * | 2012-12-07 | 2013-02-27 | 北京中奥汇成生物材料科技有限公司 | Absorbable bone screw as well as preparation method and application of absorbable bone screw |
| CN102940910B (en) * | 2012-12-07 | 2014-05-28 | 中奥汇成科技有限公司 | Absorbable bone screw as well as preparation method and application of absorbable bone screw |
| CN103585678A (en) * | 2013-11-14 | 2014-02-19 | 中山大学 | Casein-calcium carbonate microsphere modified polylactic acid membrane material as well as preparation method and application thereof |
| CN104436321A (en) * | 2014-12-25 | 2015-03-25 | 长春圣博玛生物材料有限公司 | Anchorage nail and preparation method thereof |
| CN104984414A (en) * | 2015-07-29 | 2015-10-21 | 陕西博与再生医学有限公司 | Composite absorbable interface screw and preparation method thereof |
| CN105268033A (en) * | 2015-11-06 | 2016-01-27 | 杭州锐健马斯汀医疗器材有限公司 | Absorbable reticular reinforced interface screw and preparation method thereof |
| CN110051888A (en) * | 2019-04-12 | 2019-07-26 | 杭州锐健马斯汀医疗器材有限公司 | One kind absorbable compound interface screw sheath flexible and preparation method thereof |
| CN111359025A (en) * | 2020-04-15 | 2020-07-03 | 花沐医疗科技(上海)有限公司 | Orderly-absorbed composite absorbable interface screw system with sheath and preparation method thereof |
| CN111359025B (en) * | 2020-04-15 | 2022-03-15 | 花沐医疗科技(上海)有限公司 | Orderly-absorbed composite absorbable interface screw system with sheath and preparation method thereof |
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Open date: 20081029 |