CN101292950A - Beta carotene solid dispersion and prepraring method thereof - Google Patents
Beta carotene solid dispersion and prepraring method thereof Download PDFInfo
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Abstract
The invention discloses a solid dispersion of beta-carotene and the preparation method thereof. The beta-carotene comprises one of lycopene, lutein, zeaxanthin and astaxanthin or the random mixture of the materials, belonging to the fields of drugs and health care products. The solid dispersion of beta-carotene is composed of the following raw materials by preferred weight proportions: beta-carotene: polymer: additive equals to 1:3-10:0-5. The invention adopts a melting method and a solvent method to prepare the solid dispersion of beta-carotenen, which has good light and thermal stability and water-solubility or water dispersivity. The products can be prepared into tablets, capsules, pills, oral intake liquid and beverages.
Description
Technical field
The present invention relates to kind beta-carotene solid dispersion and preparation method thereof, it belongs to medicine, field of health care products.
Background technology
The class beta-carotene comprises two compounds, and a class is carotene and lutein, and carotene comprises beta-carotene and lycopene, and lutein comprises phylloxanthin, astaxanthin, cryptoxanthin.The class beta-carotene extensively is present in occurring in nature, is a lot of biological color constituents, discovers that in recent years the class beta-carotene has important physiological function to human body.As beta-carotene is the precursor substance of VA, can be converted into VA in human body.Phylloxanthin and cryptoxanthin have special physiological properties aspect vision protection, angiocardiopathy preventing and cancer and the enhancing immunity.Lycopene and astaxanthin have than strong antioxidant action stoping the biomembranous infringement of radical pair, cancellation singlet oxygen and catch reactive oxygen free radical.
The class beta-carotene is a class liposoluble substance, is insoluble in water, chemistry, physical instability, wherein lycopene, phylloxanthin, cryptoxanthin, astaxanthin are especially unstable, comparatively responsive to light, heat, air, especially with the influence of light maximum, greatly limited its application.In addition, because it is insoluble in water, so be difficult to disperse in water, colorability is relatively poor.Therefore, its stability and aqueous dispersion Research on ability are become the emphasis that the class beta-carotene is studied.At present, existing than multiclass bata-carotene stability and Study on dispersity document and patent report, the method for employing is more, has wherein proved effectively to comprise: antioxidant etc. is packed, added to microencapsulation, enclose method, lucifuge.Main literature has: 2004 13 the 5th phases of volume of Chinese Journal of New Drugs, preparation of lycopene microcapsule and study on the stability; Dry technology and equipment magazine, 2005 the 3rd the 1st phases of volume, spray drying system lycopene microcapsule; Food and biotechnology journal, 2005 24 the 5th phases of volume, the research of lycopene water solublity clathrate; Patent comprises, Chinese patent CN1252238A is stable, contain the powdery lycopene preparation of degree of crystallinity greater than 20% lycopene, Chinese patent CN1653949A, emulsifying lycopene and preparation method thereof, day disclosure special permission 8-259829, water solublity lycopene preparation method, Chinese patent CN00806761.9, but the stable aqueous dispersions of phylloxanthin and stable water dispersed powders and preparation and application, above patent does not all relate to this patent content.
In the document patent in the past, related generally to improving the whole bag of tricks of class beta-carotene stability and water dispersion, these methods mainly comprise microencapsulation, the cyclodextrin inclusion compound method, liposome, Emulsion, emulsifying agent hydrotropy method, oil solution method, soft capsule method etc., these methods maybe can not be taken into account stability and water dispersible, or drug loading is lower, need to use organic solvent etc. in the preparation.Among the Chinese patent CN03154152.6, the preparation method of Lycopene drop pill has partly related to the content of solid dispersion, but because inventor's subjectivity is in order to prepare drop pill, in prescription, add compositions such as water-fast hard ester acid, cause this invention product can not be soluble in water fully, in addition, the preparation method melt temperature has only 85 ℃, and the lycopene fusing point is up to 170 ℃, not thoroughly fusion, lycopene can not thoroughly be dispersed in the carrier with molecular forms, does not dissolve each other fully with carrier, be not completed into complex soluble in water, finally its water solublity is relatively poor.
Summary of the invention
The present invention is for solving the problems of the technologies described above, provide a kind of to light, heat, air-stable, and can be water-soluble or the class beta-carotene solid dispersion of aqueous dispersion and preparation method thereof, this solid dispersion is owing to better intercepted light and air, therefore delayed light, thermal degradation reaction, and air oxidation reaction, thereby class beta-carotene long-time stability improved, simultaneously, this kind solid dispersion has good water-solubility or water-dispersible.
The present invention is based on following principle invention, four kinds of material chemistry similar in the class beta-carotene, all have more fat-soluble, fusing point is 160～210 ℃ of scopes, Polyethylene Glycol and poloxamer are a kind of high molecular polymers, fusing point is at 50-70 ℃, find in the present invention's research, when at 80-210 ℃ of high-temperature condition, two kinds of material mixtures can form low melting point molten thing or solid solution altogether, especially 170-210 ℃ of high-temperature region or be higher than class beta-carotene fusing point district and can be completed into solid solution, after cooling rapidly, the class beta-carotene can interweave in Polyethylene Glycol or poloxamer crystal with microcrystalline form, form a kind of space solid solution, be solid dispersion, or, can partly form low melting point eutectic being lower than the temperature fusion of fusing point.The present invention also finds, adopts the mixture of Polyethylene Glycol and two kinds of materials of poloxamer, also can obtain similar effects.Above-mentioned solid dispersion also can adopt solvent method or solvent fusion method to obtain, and method is that class beta-carotene and polymer are dissolved in organic solvent, solvent flashing then, and drying obtains solid dispersion.Obtain can adding additives in this solid dispersion, at emulsifying agent more than 10 or water solublity colloid material, form joint vector as saccharide or HLB value, its water solublity and water-dispersible also can be strengthened, and increase stability simultaneously.
Owing to adopt high-temperature melting method to prepare solid dispersion, may make class beta-carotene and carrier Polyethylene Glycol that the tendency of oxidation is arranged, therefore suitably add some antioxidant and suit, as BHT, V
E, V
CEster etc.
According to top described, for addressing the above problem, class beta-carotene solid dispersion of the present invention, it by following raw material by weight forming class bata-carotene: polymer: additives=1: 1～20: 0～10.
Class beta-carotene solid dispersion of the present invention is made of class bata-carotene: polymer: additives=1: 3～10: 0～5 according to preferred weight ratio following raw material.
Described class beta-carotene is a kind of in lycopene, phylloxanthin, cryptoxanthin, the astaxanthin or their any mixture.
Described polymer is a kind of of Polyethylene Glycol, poloxamer, polyvinylpyrrolidone or their any mixture; Polyethylene Glycol wherein is all models of 200-20000 or their mixture, preferred PEG3350 to PEG8000 model, poloxamer wherein is any mixture of any one or they in all models of 108-407, any one in preferred 124,188,237,338,407 or their any mixture.
Described additives are a kind of of emulsifying agent and glucide and gelatin substance or their mixture.
Described emulsifying agent is phospholipid, sucrose fatty acid ester, the hard ester acid esters of sucrose, polysorbas20-80, ten polyglycereol lists with a kind of in cinnamic acid ester, ten polyglycereol monoleates, ten POGE-A POGE-B POGE-C Polyglycerin palmitate, ten polyglycereol myristinates or the hard ester acid esters of ten polyglycereol or their mixture; Saccharide is a kind of or their mixture in sucrose, lactose, galactose, glucose, polysaccharide, trehalose, dextran, mannitol or the xylitol; Gelatin substance is a kind of in gelatin, arabic gum, xanthan gum, sodium caseinate or the fish glue or their mixture.
The preparation method of one kind beta-carotene solid dispersion, it is made of by weight following raw material, class bata-carotene: polymer: additives=1: 1～20: 0～10, its preparation method comprises following processing step, get class bata-carotene and polymer by above-mentioned weight ratio, in heating tank, adopt oil bath or known heating technique, be heated to 70-210 ℃ rapidly, fusion, then, be cooled to 70-80 ℃ rapidly, add additives or do not add additives, mix homogeneously, come down in torrents at rustless steel board slot internal cooling, pulverize, cross 40 mesh sieves, get product.
Described technology melt temperature is at 160-210 ℃.
Behind class bata-carotene and polymer melt, after the cooling room temperature is pulverized, add 5-10 times of pure water dissolving, add additives, spray drying gets finished product.
Described fusion method preparation can be adopted extrusion by melting, will put into the thermosol extrusion equipment by the class bata-carotene and the polymer of above-mentioned weight ratio, is melted in 160-210 ℃, and pelletized product is extruded in cooling.
Adopt solvent method to substitute fusion method, method is that class beta-carotene and polymer are dissolved in organic solvent, as the tert-butyl alcohol or isopropyl alcohol or ethanol etc., and solvent flashing then, drying obtains solid dispersion.
Described solid dispersion is added some known adjuvants, be prepared as tablet, capsule, drop pill, oral liquid, beverage.
Described additives can not add yet.
Class bata-carotene solid dispersion advantageous effect of the present invention is as follows: this solid dispersion has good stable to light, heat, air, has good water-solubility and water dispersible, has good colorability.Can be prepared into tablet with this solid dispersion, capsule, granule, drop pill, oral liquid, the beverage several formulations can promote the stripping of class bata-carotene to improve its bioavailability.
The specific embodiment
The present invention is illustrated with following embodiment, but protection scope of the present invention is not limit by embodiment.
Class bata-carotene detection method of content of the present invention is a high-efficient liquid phase technique, and liquid-phase condition is a mobile phase methanol: acetonitrile: dichloromethane=10: 6: 5, detect wavelength 472nm, and flow velocity 1.0ml/min, column temperature, room temperature, sample size 10 μ l, external standard method is calculated content; The about 100mg of class bata-carotene is got in solubility test, adds not commensurability pure water dissolving, forms saturated solution, calculates the maxima solubility scope.
The specific embodiment
Embodiment 1
Lutein solid dispersoid of the present invention is made of phylloxanthin: Polyethylene Glycol: Tween 80=1: 5: 0.5 by weight following raw material.
Its preparation method is as follows: get phylloxanthin 10g by above-mentioned weight ratio, the 50g of Macrogol 4000 places heating tank, and oil bath is warming up to 170 ℃ rapidly, be cooled to 70-80 ℃ rapidly, add Tween 80, stir, come down in torrents on corrosion resistant plate, pulverize, cross 40 mesh sieves, that is, measuring the content phylloxanthin is 9.2%.
Embodiment 2
Lutein solid dispersoid of the present invention is formed cryptoxanthin by weight by following raw material: polyethylene glycol 6000: ten polyglycerol acrylate=1: 1: 0.2.
Its preparation method is as follows: get cryptoxanthin 100g and polyethylene glycol 6000 100g by above-mentioned weight ratio, be heated to 210 ℃ and be cooled to 70-80 ℃ rapidly, add ten polyglycerol acrylate 20g, stir, come down in torrents and on steel plate, cool off, pulverize, cross 40 mesh sieves, get finished product, recording content is 18%.
Embodiment 3
Astaxanthin solid dispersion of the present invention is prepared as follows, and gets astaxanthin 10g, and Polyethylene Glycol 3350 type 100g, adds tert-butyl alcohol 2000ml, is heated to 70 ℃, makes dissolving, and lyophilization gets finished product, and recording content is 7%.
Embodiment 4
Lycopene 10g is got in lycopene solid dispersion preparation of the present invention, and Macrogol 4000 200g, is heated to 180 ℃ rapidly, be cooled to 80 ℃, add ten polyglycereol laurates, evenly mixed, frozen cooling is to room temperature, be poured on the steel plate, pulverized 40 mesh sieves, get finished product.
Embodiment 5
Cryptoxanthin solid dispersion of the present invention is formed cryptoxanthin by weight by following raw material: poloxamer 188=1: 20.
Its preparation method is as follows: get cryptoxanthin 100g and poloxamer 188 type 300g by above-mentioned weight ratio, be heated to 210 ℃ and be cooled to room temperature rapidly, come down in torrents and cool off on steel plate, pulverize, cross 40 mesh sieves, get finished product.
Embodiment 6
Lutein solid dispersoid of the present invention is formed phylloxanthin by weight by following raw material: poloxamer 237=1: 15.
Its preparation method is as follows: get phylloxanthin 100g and poloxamer type 1000g by above-mentioned weight ratio, be heated to 210 ℃ and be cooled to room temperature rapidly, come down in torrents and cool off on steel plate, pulverize, cross 40 mesh sieves, get finished product.
Embodiment 7
Lutein solid dispersoid of the present invention is formed phylloxanthin by following raw material: poloxamer 188: Macrogol 4000=1: 3: 3 by weight.
Get phylloxanthin 100g and poloxamer 300g and Liquid Macrogol g by above-mentioned weight ratio, be heated to 180 ℃ and be cooled to room temperature rapidly, come down in torrents and on steel plate, cool off, pulverize, cross 40 mesh sieves, get finished product.
Embodiment 8
Stability test:
Get the lycopene solid dispersion 100g that embodiment 4 makes, and each 100g of lycopene raw material of same batch, according to the illumination effect factor, study on the stability is done in the temperatures involved factorial experiments.
Each 10g break into portions of above-mentioned sample is got in the illumination effect factorial experiments, places the 4000LX lamp box, does not divide, not and 0 o'clock, and 6 o'clock, 12 o'clock, 24 o'clock, 3 days, 5 days, sampling and measuring absorbance rate of descent the results are shown in Table 1 in 10 days.
Assay method: sample thief 2mg, in the 10ml volumetric flask, add an amount of ultrasonic 20min of dehydrated alcohol and cross the 0.45mn microporous filter membrane, get the 0.2ml-10ml standardize solution, be test liquid, at the 448nm wavelength, carry out absorbance measurement, and calculate the absorbance rate of descent, draw degradation rate.The results are shown in Table 1.
Each 10g of above-mentioned sample is got in high heat affecting test, and break into portions places 40 ℃ of calorstats.Respectively at 0 o'clock, 6 o'clock, 12 o'clock, 24 o'clock, 3 days, 5 days, 10 days sampling and measuring absorbance (448nm) rates of descent the results are shown in Table 2.
Table 1 illumination (4500LX) is to the phylloxanthin stability influence:
Table 2 high temperature (40 ℃) is to the phylloxanthin stability influence:
By table 2, the lycopene solid dispersion is more stable than raw material to the illumination high-temperature stability.
Embodiment 9
Class bata-carotene solid dispersion of the present invention, material is formed phylloxanthin: Macrogol 200 and 4000 mixture: phospholipid=1: 3: 0.1 according to the following weight ratio.
Its preparation method carries out according to embodiment 1 method.
Embodiment 10
Class bata-carotene solid dispersion of the present invention, material is formed cryptoxanthin: cetomacrogol 1000: Polyethylene Glycol 3350: polysorbate60=1: 1: 5: 0.2 according to the following weight ratio.
Described polysorbate60 can be replaced by polysorbas20.
Its preparation method carries out according to embodiment 1 method.
Embodiment 11
Class bata-carotene solid dispersion of the present invention, material is formed lycopene: Macrogol 4000: sucrose fatty acid ester: ten glycerine myristate esters=1: 8: 4: 2 according to the following weight ratio.
Its preparation method carries out according to embodiment 1 method.
Embodiment 12
Class bata-carotene solid dispersion of the present invention, material is formed astaxanthin: polyethylene glycol 6000: ten glyceryl oleates=1: 10: 2 according to the following weight ratio.
Its preparation method carries out according to embodiment 1 method.
Embodiment 13
Class bata-carotene solid dispersion of the present invention, material is formed phylloxanthin: cryptoxanthin: Polyethylene Glycol 8000: poloxamer 188=1: 1: 15: 3 according to the following weight ratio.
Its preparation method carries out according to embodiment 1 method.
Embodiment 14
Class bata-carotene solid dispersion of the present invention, material is formed phylloxanthin: polyethylene glycol 1500: Polyethylene Glycol 12000: sucrose fatty acid ester: ten glyceryl stearate=1: 2: 10: 2: 1 according to the following weight ratio.
Its preparation method carries out according to embodiment 1 method.
Embodiment 15
Class bata-carotene solid dispersion of the present invention, material is formed cryptoxanthin: Macrogol 4000: poloxamer 188: SY-Glyster ML 750=1: 2: 2: 1 according to the following weight ratio.
Its preparation method carries out according to embodiment 1 method.
Embodiment 16
Class bata-carotene solid dispersion of the present invention, material is formed lycopene: polyethylene glycol 6000=1: 20 according to the following weight ratio.
Its preparation method carries out according to embodiment 1 method.
Embodiment 17
Class bata-carotene solid dispersion of the present invention, material is formed astaxanthin: poloxamer 237: poloxamer 124: poloxamer 407: polysorbate60=1: 1: 1: 1: 0.5 according to the following weight ratio.
Its preparation method carries out according to embodiment 1 method.
Embodiment 18
Class bata-carotene solid dispersion of the present invention, material is formed phylloxanthin: cryptoxanthin: lycopene: Macrogol 4000: the hard ester acid esters of sucrose=1: 1: 1: 12: 0.5 according to the following weight ratio.
Its preparation method carries out according to embodiment 1 method.
Embodiment 19
Class bata-carotene solid dispersion of the present invention, material is formed cryptoxanthin: polyvinylpyrrolidone: ten glyceryl oleates=1: 10: 3 according to the following weight ratio.
Use polyvinylpyrrolidone need adopt the solvent method preparation, its preparation method carries out according to embodiment 3 methods.
Embodiment 20
Class bata-carotene solid dispersion of the present invention, material is formed lycopene: poloxamer 188: SY-Glyster ML 750: sucrose=1: 20: 0.5: 2 according to the following weight ratio.
Its preparation method carries out according to embodiment 1 method.
Embodiment 21
Class bata-carotene solid dispersion of the present invention, material is formed astaxanthin: Macrogol 2000 0: poloxamer: phospholipid: sucrose fatty acid ester: glucose=1: 8: 8: 0.2: 5: 1 according to the following weight ratio.
Preparation method is carried out according to embodiment 1 method.
Embodiment 22
Class bata-carotene solid dispersion of the present invention, material is formed lycopene: astaxanthin: Macrogol 200,4000 mixture: poloxamer 188: mannitol=0.5: 0.5: 1: 5: 3 according to the following weight ratio.
Preparation method is carried out according to embodiment 1 method.
Embodiment 23
Class bata-carotene solid dispersion of the present invention, material is formed phylloxanthin: poloxamer 237: trehalose=1: 10: 1 according to the following weight ratio.
Preparation method is carried out according to embodiment 1 method.
Embodiment 24
Class bata-carotene solid dispersion of the present invention, material is formed cryptoxanthin: poloxamer 338=1: 3 according to the following weight ratio.
Preparation method is carried out according to embodiment 1 method.
Embodiment 25
Class bata-carotene solid dispersion of the present invention, material is formed lycopene: cetomacrogol 1000: Macrogol 4000: dextran: xylitol=1: 2: 2: 1: 0.5 according to the following weight ratio.
Preparation method is carried out according to embodiment 1 method.
Embodiment 26
Class bata-carotene solid dispersion of the present invention, material is formed astaxanthin: poloxamer 188: poloxamer 338: galactose: maltose=1: 1: 2: 1: 1 according to the following weight ratio.
Preparation method is carried out according to embodiment 1 method.
Embodiment 27
Class bata-carotene solid dispersion of the present invention, material is formed phylloxanthin: Macrogol 4000: sucrose: gelatin: xanthan gum=1: 4: 1: 3: 1 according to the following weight ratio.
Preparation method is carried out according to embodiment 1 method.
Embodiment 28
Class bata-carotene solid dispersion of the present invention, material is formed cryptoxanthin: polyethylene glycol 6000: glucose: maltose: fish glue=1: 3: 1: 1: 3 according to the following weight ratio.
Preparation method is carried out according to embodiment 1 method.
Embodiment 29
Class bata-carotene solid dispersion of the present invention, material is formed lycopene: poloxamer 338: cetomacrogol 1000: trehalose: sodium caseinate: arabic gum=1: 4: 3: 1: 3: 1 according to the following weight ratio.
Its preparation method carries out according to embodiment 1 method.
Embodiment 30
Class bata-carotene solid dispersion of the present invention, material is formed astaxanthin: Polyethylene Glycol 3350: the hard ester acid esters of sucrose: sorbitol: fish glue: xanthan gum=1: 3: 5: 1: 3: 1 according to the following weight ratio.
Its preparation method carries out according to embodiment 1 method.
Embodiment 31
Class bata-carotene solid dispersion of the present invention is formed phylloxanthin by weight by following raw material: poloxamer 188: Macrogol 4000: sucrose=1: 3: 3: 1.
Its preparation method is as follows: get phylloxanthin 100g and poloxamer 300g and Liquid Macrogol g and sucrose 100g by above-mentioned weight ratio, be heated to 180 ℃ and be cooled to room temperature rapidly, come down in torrents and cool off on steel plate, pulverize, cross 40 mesh sieves, get finished product.
Embodiment 32
Press the fused mass of embodiment 1 preparation method preparation, add 8 times of water dissolutioies, add gelatin 20g and trehalose 5g, make dissolving, spray drying gets finished product.
Embodiment 33
Press embodiment 1 class bata-carotene and polymer weight ratio, get material and join in the thermosol extruder, melt temperature is 180 ℃, the room temperature cooling, and extrusion temperature is 50 ℃, makes granular finished product.
Embodiment 34
Getting cryptoxanthin 1g mixes with Polyethylene Glycol 3g, carry out heat and analyze differential scanning DSC, heating rate is 10 ℃/min, be warming up to 210 ℃, after the cooling, repeat to be warming up to 210 ℃, the DSC spectrum shows cryptoxanthin 208 ℃ of disappearances in fusing point peak as a result, form new endothermic peak at 65 ℃, both have formed solid solution.
Embodiment 35
The sample 100mg of embodiment 4 is got in solubility test, adds purified water, makes saturated solution, and recording dissolubility is 20mg/ml.
Embodiment 36
Press the raw material of embodiment 1 preparation, behind heating and melting on the drop pill machine, be prepared into drop pill.
Embodiment 37
Press the raw material of embodiment 1 preparation, add lactose, use the tablet machine tabletting.
Embodiment 38
Press the raw material of embodiment 1 preparation,, be prepared into soft capsule with the edible oil dissolving.
Embodiment 39
Press the raw material of embodiment 1 preparation, add water and spice, sugar, make oral liquid or beverage.
Claims (10)
1, a kind beta-carotene solid dispersion, it is characterized in that it by following raw material by weight forming class bata-carotene: polymer: additives=1: 1～20: 0～10.
2, by the described class beta-carotene of claim 1 solid dispersion, it is characterized in that it by following raw material by weight forming class bata-carotene: polymer: additives=1: 3～10: 0～5.
3,, it is characterized in that described class beta-carotene is a kind of in lycopene, phylloxanthin, cryptoxanthin, the astaxanthin or their any mixture by claim 1 or 2 described class beta-carotene solid dispersion.
4,, it is characterized in that described polymer is a kind of of Polyethylene Glycol, poloxamer, polyvinylpyrrolidone or their any mixture by claim 1 or 2 described class beta-carotene solid dispersion; Polyethylene Glycol wherein is all models of 200-20000 or their mixture, and poloxamer wherein is any mixture of any one or they in all models of 108-407.
5,, it is characterized in that described additives are a kind of in emulsifying agent, glucide or the gelatin substance or their mixture by claim 1 or 2 described class beta-carotene solid dispersion.
6,, it is characterized in that described emulsifying agent is a kind of in phospholipid, sucrose fatty acid ester, the hard ester acid esters of sucrose, polysorbas20-80, ten polyglycereol monolaurates, ten polyglycereol monoleates, ten POGE-A POGE-B POGE-C Polyglycerin palmitate, ten polyglycereol myristinates or the hard ester acid esters of ten polyglycereol or their mixture by the described class beta-carotene of claim 4 solid dispersion; Saccharide is a kind of or their mixture in sucrose, lactose, galactose, glucose, polysaccharide, trehalose, dextran, mannitol or the xylitol; Gelatin substance is a kind of in gelatin, arabic gum, xanthan gum, sodium caseinate or the fish glue or their mixture.
7, the preparation method of a kind beta-carotene solid dispersion, it is made of by weight following raw material, class bata-carotene: polymer: additives=1: 1～20: 0～10, its preparation method comprises following processing step, get class bata-carotene and polymer by above-mentioned weight ratio, in heating tank, adopt oil bath or known heating technique, be heated to 70-210 ℃ rapidly, fusion, then, be cooled to 70-80 ℃ rapidly, add additives or do not add additives, mix homogeneously, come down in torrents at rustless steel board slot internal cooling, pulverize, cross 40 mesh sieves, get product.
8, the preparation method of a kind beta-carotene solid dispersion, it forms class bata-carotene: polymer by weight by following raw material: additives=1: 1～20: 0～10, its preparation method comprises following processing step, will put into the hot melt extrusion equipment by the class bata-carotene and the polymer of above-mentioned weight ratio, is melted in 160-210 ℃, after the fusion, cooling after room temperature is pulverized, adds 5-10 times of pure water dissolving, add additives, spray drying, pelletized product is extruded in cooling.
9, press the preparation method of the described class beta-carotene of claim 6 solid dispersion, it is characterized in that adopting solvent method to substitute fusion method, it is that class beta-carotene and polymer are dissolved in organic solvent, as the tert-butyl alcohol or isopropyl alcohol or ethanol etc., solvent flashing then, drying obtains solid dispersion.
10, by the described class beta-carotene of claim 1 solid dispersion, described solid dispersion is added some known adjuvants, be prepared as tablet, capsule, drop pill, oral liquid, beverage.
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