CN1012897B - Electric infiltration technology and apparatus for extracting lactic acid - Google Patents
Electric infiltration technology and apparatus for extracting lactic acidInfo
- Publication number
- CN1012897B CN1012897B CN87104858.2A CN87104858A CN1012897B CN 1012897 B CN1012897 B CN 1012897B CN 87104858 A CN87104858 A CN 87104858A CN 1012897 B CN1012897 B CN 1012897B
- Authority
- CN
- China
- Prior art keywords
- chamber
- lactic acid
- electrodialyzer
- extraction
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 title claims abstract description 57
- 239000004310 lactic acid Substances 0.000 title claims abstract description 28
- 235000014655 lactic acid Nutrition 0.000 title claims abstract description 28
- 238000005516 engineering process Methods 0.000 title abstract description 4
- 230000008595 infiltration Effects 0.000 title description 2
- 238000001764 infiltration Methods 0.000 title description 2
- 238000000034 method Methods 0.000 claims abstract description 17
- 238000000909 electrodialysis Methods 0.000 claims abstract description 12
- 239000007788 liquid Substances 0.000 claims description 27
- 239000012528 membrane Substances 0.000 claims description 11
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 7
- 238000005349 anion exchange Methods 0.000 claims description 6
- 125000002091 cationic group Chemical group 0.000 claims description 6
- 239000012141 concentrate Substances 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 239000002253 acid Substances 0.000 claims description 4
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 4
- 239000011707 mineral Substances 0.000 claims description 4
- 239000008399 tap water Substances 0.000 claims description 4
- 235000020679 tap water Nutrition 0.000 claims description 4
- 239000008367 deionised water Substances 0.000 claims description 3
- 229910021641 deionized water Inorganic materials 0.000 claims description 3
- 239000012153 distilled water Substances 0.000 claims description 3
- 238000007865 diluting Methods 0.000 claims 1
- -1 form by electrode Substances 0.000 claims 1
- 238000000605 extraction Methods 0.000 abstract description 10
- 238000000855 fermentation Methods 0.000 abstract description 7
- 230000004151 fermentation Effects 0.000 abstract description 7
- 238000005342 ion exchange Methods 0.000 abstract description 7
- 238000002425 crystallisation Methods 0.000 abstract description 5
- 230000008025 crystallization Effects 0.000 abstract description 5
- 159000000007 calcium salts Chemical class 0.000 abstract description 3
- 150000007524 organic acids Chemical class 0.000 abstract description 3
- 238000000926 separation method Methods 0.000 abstract description 3
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 abstract 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 abstract 1
- 239000001630 malic acid Substances 0.000 abstract 1
- 235000011090 malic acid Nutrition 0.000 abstract 1
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 description 4
- 239000001527 calcium lactate Substances 0.000 description 4
- 229960002401 calcium lactate Drugs 0.000 description 4
- 235000011086 calcium lactate Nutrition 0.000 description 4
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 4
- 239000002562 thickening agent Substances 0.000 description 4
- 239000002699 waste material Substances 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- 238000003912 environmental pollution Methods 0.000 description 2
- 235000010755 mineral Nutrition 0.000 description 2
- 238000004448 titration Methods 0.000 description 2
- 238000007599 discharging Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- NGSFWBMYFKHRBD-UHFFFAOYSA-N sodium;2-hydroxypropanoic acid Chemical compound [Na+].CC(O)C(O)=O NGSFWBMYFKHRBD-UHFFFAOYSA-N 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
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- Separation Using Semi-Permeable Membranes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The present invention belongs to the technical field of a method and equipment for the separation and extraction of organic acid in fermentation industry, which aims to replace three processes of concentration, crystallization and acidolysis with large labor strength, poor condition and serious pollution in a calcium salt method by electrodialysis, and an electrodialyzer for the extraction of lactic acid is designed. The extraction technology of the present invention is characterized in that fermentation liquor is extracted through the processes of the electrodialyzer, vacuum concentration, an ion exchange column, etc. The electrodialyzer used by the present invention is composed of one or a plurality of film piles, wherein four kinds of chambers are arranged in each film pile. The technology can be used for the separation and extraction of malic acid, and can enable the extraction yield of lactic acid to reach 85%; meanwhile, the quality of the lactic acid accords with the standard of British Pharmacopoeia (Version 80).
Description
The invention belongs to organic acid separating and extracting method and equipment technical field in the fermentation industry.
Lactic acid is a kind of organic acid commonly used in food, medicine, the chemical industry, and its production method mainly contains chemosynthesis and two kinds of methods of fermentation, and the lactic acid-producing of China mainly adopts fermentation method.Calcium salt method is all adopted in the extraction of lactic acid in the at present domestic and international fermentation industry.This method, crystallization condition is difficult to grasp, the percent crystallization in massecuite instability of calcium lactate so need big place, spends the more time, the workshop section of acidolysis simultaneously will consume a large amount of sulfuric acid, produce a large amount of calcium sulfate waste residues, labor strength is big, poor working environment, environmental pollution is serious, lactic acid yield low (domestic about 50%).French YPrigent et AFranco had delivered the method for extracting Sodium.alpha.-hydroxypropionate with electrodialysis one ultrafiltration process in 1984.Japanese Motoyoshi Hongo etal in 1986 have delivered the novel method of electrodialysis one fermenting lactic acid, but the structure of this method from the technological line to the electrodialyzer all can't be used for producing in the near future.
Purpose of the present invention and task be replace in the calcium salt method with electroosmose process concentrate, crystallization, acidolysis three road labour intensity maximums, labor condition is the poorest, environmental pollution is the most serious operation, and design a kind of electrodialyzer that is used for lactic acid extraction, for the automatic control that realizes lactic acid-producing lays the foundation.
Lactic acid electrodialysis extraction process of the present invention as shown in Figure 1, fermented liquid (1) through pretreater (2) to electrodialyzer (4) the calcium lactate clear liquid is gone into thickener (6) and is concentrated, concentrated solution feeds cationic exchange coloum (7), anion-exchange column (8), get ion exchange liquid, through thickener (11), vacuum concentration gets finished product lactic acid (12) again.Wherein electrodialyzer (II) number chamber raffinate (5) can be back to (1) circulation, and ion exchange liquid (9) (10) can be back to (6) and concentrate.Specifically be that fermented liquid adds activated carbon decolorizing suddenly, be incubated half an hour, filter clear liquid, with certain speed clear liquid is fed electrodialysis shown in Figure 2 (II) chamber with pump, distilled water (or deionized water) is fed (I) chamber, tap water is fed (III) chamber, certain density mineral acid is fed (IV) chamber and two electrode vessels, wherein the effluent liquid of (I) (II) (IV) and electrode vessel still returns original stationary tank, circulation again and again, the electrodialysis liquid that obtains is by a certain size a H
+The formula cationic exchange coloum, gained ion exchange liquid vacuum concentration to lactic acid concn is about 50%, again by a certain size a OH
-The formula anion-exchange column, the ion exchange liquid vacuum concentration is to finished product lactic acid.
Lactic acid electrodialyzer of the present invention is made of positive plate (1), negative plate (2), anode membrane (3), cavity block (4), dividing plate as shown in Figure 2.This electrodialyzer can be a membrane stack, also can be a plurality of membrane stacks, the logarithm of film is the amount doesn't matter in each membrane stack, the size of film is changeable, these are all decided on the scale of producing and test, and electrode institute making alive size is according to the logarithm of film in the membrane stack, the performance of film, the bridging mode of membrane stack and decide have four types chamber in each membrane stack.
Utilize technology of the present invention to extract lactic acid, replaced that calcium lactate concentrates, crystallization and three steps of acidolysis, do not produce the calcium sulfate waste residue, extract yield and can reach more than 85%, the lactic acid concn of electrodialysis liquid can reach more than 15%, and quality product meets British Pharmacopoeia (80 editions) standard.
Extracting method of the present invention is equally applicable to the separation and Extraction of oxysuccinic acid.
Be embodiments of the invention below.
(Ca is measured in first titration to get the 500ml fermented liquid
2+Concentration is also calculated content) add 0.5% gac, 60 ℃ are incubated half an hour, filter clear liquid, feed electrodialyzer (II) number chamber shown in Figure 2 with pump with 8l/ hour speed then, use simultaneously pump with same speed with distilled water (or deionized water), tap water feed (I), (III) number chamber respectively, with the HCl of 0.5N and the H of 0.5N
2SO
4Feed (IV) number chamber and two electrode vessels.Wherein the effluent liquid of (I) (II) (IV) chamber and two electrode vessels still returns original stationary tank, circulation again and again, and (III) number chamber effluent liquid discharging discards, and per twice cycle sampling in (I) (II) two Room be titration acidity and Ca respectively
2+Content, (IV) chamber constantly adds an amount of hydrochloric acid, makes the concentration of hydrochloric acid in the stationary tank keep 0.5N, drops to 0.5% to the concentration of (II) chamber calcium lactate and stops electrodialysis when following.Allow the H of electrodialysis liquid by a 3 * 20cm of (I) chamber gained
+The formula cationic exchange coloum, gained ion exchange liquid vacuum concentration to lactic acid concn is about 50%, again by a 3 * 0cmOH
-The formula anion-exchange column, the ion exchange liquid vacuum concentration gets finished product lactic acid.
Description of drawings:
Fig. 1. lactic acid electrodialysis extraction process schema
(1) fermented liquid, (2) pretreater, (3) waste residue, (4) electrodialyzer, (5) electrodialyzer (II) chamber raffinate, (6) thickener, (7) cationic exchange coloum (8) anion-exchange column, (9) defective cationic exchange coloum effluent liquid, (10) defective anion-exchange column effluent liquid, (11) thickener, (12) lactic acid qualified product.
Fig. 2. the electrodialyzer schema
(I) No. one chamber, (II) No. two chamber, (III) No. three chamber, (IV) No. four chamber, (1) positive plate, (2) negative plate, (3) anode membrane, (4) cavity block, (5) electrode solution, (6) lactic acid electrodialysis liquid, (7) lactic acid fermentation liquid, (8) tap water, (9) mineral acid, (10) pump, (11) solution storage tank.
Claims (3)
1, a kind of lactic acid electrodialysis extracting method, it is characterized in that fermented liquid through electrodialyzer, cationic exchange coloum, anion-exchange column, operation such as concentrate and extract.
2, extracting method according to claim 1 is characterized in that fermented liquid feeds No. two chamber of electrodialyzer, distilled water (or deionized water) feeds No. one chamber, tap water and feeds chamber, certain density mineral acid No. four chamber of feeding and two electrode vessels No. three.
3, a kind of electrodialyzer that is used to extract lactic acid, form by electrode, cavity block, anode membrane, dividing plate, it is characterized in that forming, four types chamber, I chamber lactic acid concentrate chamber, II chamber fermented liquid diluting compartment, III chamber mineral ion concentrate chamber, IV chamber hydrochloric acid supply chamber are arranged in each membrane stack by one or more membrane stacks.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN87104858.2A CN1012897B (en) | 1987-07-11 | 1987-07-11 | Electric infiltration technology and apparatus for extracting lactic acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN87104858.2A CN1012897B (en) | 1987-07-11 | 1987-07-11 | Electric infiltration technology and apparatus for extracting lactic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1031112A CN1031112A (en) | 1989-02-15 |
| CN1012897B true CN1012897B (en) | 1991-06-19 |
Family
ID=4815038
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN87104858.2A Expired CN1012897B (en) | 1987-07-11 | 1987-07-11 | Electric infiltration technology and apparatus for extracting lactic acid |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1012897B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100409926C (en) * | 2006-01-23 | 2008-08-13 | 哈尔滨工业大学 | Frequently pole-reversing electroosmosis method for extracting and concentrating sodium lactate from garbage fermentation liquid |
| CN101392273B (en) | 2008-11-10 | 2013-02-06 | 南京工业大学 | Clean production process of lactic acid |
| CN101792384A (en) * | 2010-03-12 | 2010-08-04 | 韩硕 | Electric infiltration method and device for extracting pyruvic acid |
| CN101966426B (en) * | 2010-09-15 | 2012-07-25 | 中国科学院过程工程研究所 | Electric dialyzator for desalting fermentation liquor |
| CN113120916B (en) * | 2019-12-31 | 2022-10-11 | 中国石油化工股份有限公司 | Method for modifying molecular sieve by using multivalent noble metal |
-
1987
- 1987-07-11 CN CN87104858.2A patent/CN1012897B/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CN1031112A (en) | 1989-02-15 |
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