CN101279014A - Medicinal composition for treating pelvic inflammatory disease and preparation method thereof - Google Patents

Abstract

The invention relates to a pharmaceutical composition for curing pelvic inflammation. The traditional Chinese medicine composition is prepared by radix salivae miltiorrhizae, tangerine seed, fennel, rhizoma corydalis, chinaberry fruit, trogoterus dung, bitter orange, combined spicebush root, americanwater plantain, angelica sinensis, rhizomaligustici chuanxiong, myrrh, poria cocos, atractylodes ovata and/or pharmaceutically acceptable carrier. The invention also relates to a preparation method of the pharmaceutical composition. The pharmaceutical composition of the invention has the functions of promoting qi and activating blood, warming womb and dissipating cold, invigorating spleen and solving dampness, removing blood stasis and relieving pain, etc. and can be used for curing the diseases caused by pelvic inflammation, such as hypogastralgia, fever, shivering, headache, inappetence, etc.

Description

A kind of drug regimen for the treatment of pelvic inflammatory disease and preparation method thereof

Technical field:

The present invention relates to a kind of Chinese medicine composition, specifically, relate to a kind of drug regimen for the treatment of pelvic inflammatory disease and preparation method thereof.

Background technology

Pelvic inflammatory disease is the general designation that female internal genital organs (as uterus, fallopian tube, ovary, pelvic peritoneum) and connective tissue on every side thereof, pelvic peritoneum are inflamed by cell invasion.

The pathogen that causes pelvic inflammatory disease is staphylococcus, escherichia coli, streptococcus, anaerobe and the pathogen that spreads through sex intercourse such as gonococcus, herpesvirus, chlamydia trachomatis and mycoplasma etc.The main route of infection have: the menses circulating propagation, spread, spread and the metainfective direct extension of adjacent organ etc. along the genitals mucosa is up through lymphsystem.

Pelvic inflammatory disease is the commonly encountered diseases of gynecological, and inflammation can be confined to a position, also can fall ill simultaneously at several positions.Divide acute and chronic two kinds:

1. acute pelvic inflammatory disease: the actute infection medical history is arranged, lower abdomen dull pain, muscular tone, tenderness and rebound tenderness are arranged,, heating fast with heart rate, vagina have a large amount of purulent secretions.Be in a bad way hyperpyrexia can be arranged, headache, shiver with cold, inappetence, a large amount of yellow leucorrhea have flavor, lower abdominal distention pain, tenderness, waist to ache etc.; Occur to feel sick when peritonitis is arranged, abdominal distention, vomiting, diarrhoea etc.; When having abscess to form, lower abdomen enclosed mass and local compression irritation can be arranged, before enclosed mass is positioned at dysuria, frequent micturition, dysurea etc. can be arranged; After being positioned at, enclosed mass can cause diarrhoea, tenesmus sense and difficult defecation.

2. chronic pelvic inflammatory disease: General Symptoms is for having low grade fever, susceptible fatigue sometimes, and neurasthenia symptom appears in part patient owing to the course of disease is long, as insomnia, lassitude, whole body discomfort etc.Hypogastric region weigh down to expand, pain and lumbosacral region are ached aggravation after the fatigue of being everlasting, the sexual intercourse, before and after the menstruation.Owing to chronic inflammatory disease causes pelvic congestion, menorrhagia, menoxenia can appear during the ovarian function infringement, and fallopian tube adhesion can cause infertility when blocking.Acute inflammation might cause that diffuse peritonitis, septicemia are so that serious consequences such as septic shocks; Chronic inflammatory disease is shown effect repeatedly, and is influenced women's operate as normal and life and physical and mental health owing to obstinate.

This disease cause of disease mainly contains following several:

(1) infect puerperal or post-abortion: have a delicate constitution after patient's puerperal or the abortion, the cervix uteri mouth is not closed as yet well through expansion, at this moment the possible up infection pelvic cavity of the antibacterial that exists in vagina, the cervix uteri; If still have Placenta Hominis, fetal membrane residual in the uterine cavity, then the chance of Gan Raning is bigger.

(2) gynecilogical operation postoperative infection: artificial abortion, put ring or get annuloplasty surgery, hydrotubation, salpingography, endometrial polyp enucleation, or under the mucosa during hysteromyomectomia, if sterilize not strict or original reproductive system chronic inflammatory disease, promptly might cause postoperative infection.Do not note Personal hygiene behind the corrective surgery that also has, or postoperative is against medical advice, and sexual life is arranged, can makes the up infection of antibacterial equally, cause pelvic inflammatory disease.

(3) menstrual phase is not noted health: the intermenstrual period endometrium is stripped off, and blood sinus is open in the uterine cavity, and has sludged blood to exist, and this is the good condition of bacteria breed.If do not note health at intermenstrual period, use underproof sanitary towel of sanitary standard or toilet paper, or sexual life is arranged, the chance of retrograde infection will be provided to antibacterial, cause pelvic inflammatory disease.

The prevention pelvic inflammatory disease should note following some:

Acute pelvic inflammatory disease:

1. note menstrual period, pregnancy period, term and puerperal hygiene, prevention infection.

2. perform preceding preparation of art of gynecilogical operation.Note keeping pudendum cleaning, sexual intercourse is avoided in first three sky of art; Postoperative is noted pudendum, vagina cleaning, washes pudendum with warm water's duty, in time changes perineal pad and underwear, forbids sexual intercourse in 2～3 weeks.

3. thoroughly cure acute pelvic inflammatory disease, prevent to transfer to chronic.

Chronic pelvic inflammatory disease: note Personal hygiene, have additional nutrients, take exercises, Abwehrkraft des Koepers is struck a proper balance between work and rest, is improved to health invigorating, attention, in time thoroughly treat acute pelvic inflammatory disease.

The traditional Chinese medical science thinks that pelvic inflammatory disease belongs to categories such as " lower abdominal pain ", " leukorrheal diseases ", " menoxenia ", " lump in the abdomen ".Its etiology and pathogenesis is because exopathogen is invaded among the long-pending born of the same parents of the stasis of blood, so that dashes and appoint visceral dysfunction, and disorder of QI movement, meridians are obstructed and cause the soreness of waist, stomachache, leukorrhagia, dysmenorrhea etc.Carry as " married woman's good recipe ": " married woman's menstruation painful abdominal mass plug is obstructed.Or puerperal is surplus not to the greatest extent, thereby gets cold with fair wind, taken advantage of by air-cooled, blood get cold then be blood stasis also.Blood stasis is interior, then body heat yellowish complexion constantly.The stasis of blood does not disappear for a long time, then for gathering lump in the abdomen." this section words have promptly described the cause of disease of pelvic inflammatory disease, the formation of symptom and scorching piece.

The pathology character of primary disease is failed to keep an appointment with deficiency of kidney-QI, dai channel and is this, damp and hot, blood stasis, cold coagulation, phlegm-damp are mark, belong to the deficiency in origin and excess in superficiality card, its pathological change is relevant with menstrual cycle: delayed menstrual cycle is because the uterus inanition, the Liver and kidney essence and blood is tending towards the temporary transient not enough stage in the body, the body defense function reduces, and pathogenic factor is taken advantage of a weak point in opponent's defence and done; The premenstrua stagnation of liver-QI of suffering from a deficiency of the kidney influences spleen fortune, and downward flow of dampness causes all diseases of primary disease more than outbreak before and after the menstruation or increase the weight of.

The traditional Chinese medical science is divided into three types with primary disease:

Damp-heat type: see the soreness of waist, lower abdominal pain, profuse leukorrhea, yellow skin, matter is thick, flavor is smelly, menoxenia or many, the yellowish urine dry stool of amount, red tongue with yellowish and greasy fur, slippery and rapid pulse person in advance more, control with clearing away heat-damp and promoting diuresis, blood circulation promoting and blood stasis dispelling.

Cold-dampness type; The delay of many courses of disease with the passing of time, aversion to cold and cold limbs, lower abdominal distention pain, creeping chill is arranged, the few color of amount delayed menstrual period is dark, the clear rare amount of leukorrhagia is many, pale tongue or have that petechia, tongue are greasy in vain, the deep-slow pulse person, control with dispelling cold by warming the meridian, blood stasis dispelling and dehumidify.

Spleen kidney deficiency type: many lower abdominal paines and lower abdomen both sides have a dull ache, even lead and lumbosacral aching pain, profuse leukorrhea are rare clearly, mental weariness, not warm, the big loose stool of extremity are thin, thin and greasy fur, the heavy person of thready pulse, control with tonifying speen and tonifying kidney.

The traditional Chinese medical science adopts this disease of decoction for the treatment of promoting flow of QI and blood, warming uterus for dispelling cold, invigorating spleen to remove dampness, blood-activating analgetic.

Summary of the invention

The purpose of this invention is to provide a kind of drug regimen for the treatment of pelvic inflammatory disease.

The present invention also aims to provide a kind of preparation method of this drug regimen.

In order to realize purpose of the present invention, the invention provides a kind of drug regimen for the treatment of pelvic inflammatory disease, be to make by effective ingredient and/or pharmaceutically acceptable carrier, described effective ingredient is made by weight by following raw materials according:

Radix Salviae Miltiorrhizae 10-20 part Semen Citri Reticulatae 10-20 part Fructus Foeniculi 5-10 part

Rhizoma Corydalis 20-25 part Fructus Toosendan 10-15 part Oletum Trogopterori 10-20 part

Fructus Aurantii 15-25 part Radix Linderae 10-20 part Rhizoma Alismatis 15-25 part

Radix Angelicae Sinensis 20-30 part Rhizoma Chuanxiong 20-25 part Myrrha 10-20 part

Poria 5-10 part Rhizoma Atractylodis Macrocephalae 10-20 part

Effective ingredient is preferably made by weight by following raw materials according:

8 parts of 16 parts of Fructus Foeniculi of 15 parts of Semen Citri Reticulataes of Radix Salviae Miltiorrhizae

16 parts of 13 parts of Oletum Trogopteroris of 23 parts of Fructus Toosendans of Rhizoma Corydalis

21 parts of 16 portions of Rhizoma Alismatis of 21 parts of Radixs Linderae of Fructus Aurantii

16 parts of 23 parts of Myrrhas of 26 parts of Rhizoma Chuanxiongs of Radix Angelicae Sinensis

16 parts of 8 parts of Rhizoma Atractylodis Macrocephalaes of Poria

The present invention also provides a kind of preparation method of this drug regimen, comprises the steps:

(1) Fructus Aurantii, that Semen Citri Reticulatae is ground into impalpable powder is standby;

(2) Oletum Trogopterori, the Radix Linderae, the Rhizoma Atractylodis Macrocephalae, Radix Salviae Miltiorrhizae, Fructus Foeniculi, Rhizoma Corydalis, Fructus Toosendan, Rhizoma Alismatis, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Myrrha, Poria decoct with water secondary, each 2 hours, filter, merging filtrate, concentrating under reduced pressure adds ethanol to 60%, leaves standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder, drying, be ground into fine powder, make granule, capsule and pill with pharmaceutically acceptable carrier.

Drug regimen of the present invention can with receivable carrier pharmaceutically, for example: filler such as starch, microcrystalline Cellulose etc.; Binding agent such as vitamin derivative, starch etc.; Mode by granule, capsule, tablet oral administration is used.

Drug regimen of the present invention has effects such as promoting flow of QI and blood, warming uterus for dispelling cold, invigorating spleen to remove dampness, blood-activating analgetic, is used for diseases such as hypogastralgia that pelvic inflammatory disease causes, fever, shiver with cold, headache, inappetence.

The specific embodiment:

Following examples are used to illustrate the present invention, but are not used for limiting the scope of the invention.

Embodiment 1:

(1) Fructus Aurantii 210g, that Semen Citri Reticulatae 160g is ground into impalpable powder is standby;

(2) Oletum Trogopterori 160g, Radix Linderae 160g, Rhizoma Atractylodis Macrocephalae 160g, Radix Salviae Miltiorrhizae 150g, Fructus Foeniculi 80g, Rhizoma Corydalis 230g, Fructus Toosendan 130g, Rhizoma Alismatis 210g, Radix Angelicae Sinensis 260g, Rhizoma Chuanxiong 230g, Myrrha 160g, Poria 80g decoct with water secondary, each 2 hours, filter, merging filtrate, concentrating under reduced pressure adds ethanol to 60%, leaves standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder, drying, be ground into fine powder, add dextrin 700g, lactose 380g, mixing, sieve, promptly with 70% ethanol wet granulation.

Embodiment 2:

(1) Fructus Aurantii 210g, that Semen Citri Reticulatae 160g is ground into impalpable powder is standby;

(2) Oletum Trogopterori 160g, Radix Linderae 160g, Rhizoma Atractylodis Macrocephalae 160g, Radix Salviae Miltiorrhizae 150g, Fructus Foeniculi 80g, Rhizoma Corydalis 230g, Fructus Toosendan 130g, Rhizoma Alismatis 210g, Radix Angelicae Sinensis 260g, Rhizoma Chuanxiong 230g, Myrrha 160g, Poria 80g decoct with water secondary, each 2 hours, filter, merging filtrate, concentrating under reduced pressure, add ethanol to 60%, left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder, dry, be ground into fine powder, add dextrin 700g mixing, in the capsulae vacuus of packing into promptly.

Embodiment 3:

(1) Fructus Aurantii 210g, that Semen Citri Reticulatae 160g is ground into impalpable powder is standby;

(2) Oletum Trogopterori 160g, Radix Linderae 160g, Rhizoma Atractylodis Macrocephalae 160g, Radix Salviae Miltiorrhizae 150g, Fructus Foeniculi 80g, Rhizoma Corydalis 230g, Fructus Toosendan 130g, Rhizoma Alismatis 210g, Radix Angelicae Sinensis 260g, Rhizoma Chuanxiong 230g, Myrrha 160g, Poria 80g decoct with water secondary, each 2 hours, filter, merging filtrate, concentrating under reduced pressure, add ethanol to 60%, left standstill 48 hours, and got supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, add above-mentioned fine powder, drying is ground into fine powder, adds refined honey 40g and an amount of water, general ball is made water-honeyed pill.

Claims (4)

1, a kind of drug regimen for the treatment of pelvic inflammatory disease is to be made by effective ingredient and/or pharmaceutically acceptable carrier, it is characterized in that described effective ingredient is made by weight by following raw materials according:

Radix Salviae Miltiorrhizae 10-20 part Semen Citri Reticulatae 10-20 part Fructus Foeniculi 5-10 part

Rhizoma Corydalis 20-25 part Fructus Toosendan 10-15 part Oletum Trogopterori 10-20 part

Fructus Aurantii 15-25 part Radix Linderae 10-20 part Rhizoma Alismatis 15-25 part

Radix Angelicae Sinensis 20-30 part Rhizoma Chuanxiong 20-25 part Myrrha 10-20 part

Poria 5-10 part Rhizoma Atractylodis Macrocephalae 10-20 part.

2, drug regimen as claimed in claim 1 is characterized in that described effective ingredient made by weight by following raw materials according:

8 parts of 16 parts of Fructus Foeniculi of 15 parts of Semen Citri Reticulataes of Radix Salviae Miltiorrhizae

16 parts of 13 parts of Oletum Trogopteroris of 23 parts of Fructus Toosendans of Rhizoma Corydalis

21 parts of 16 portions of Rhizoma Alismatis of 21 parts of Radixs Linderae of Fructus Aurantii

16 parts of 23 parts of Myrrhas of 26 parts of Rhizoma Chuanxiongs of Radix Angelicae Sinensis

16 parts of 8 parts of Rhizoma Atractylodis Macrocephalaes of Poria.

3,, it is characterized in that described drug regimen can be made into granule, capsule and pill as the arbitrary described drug regimen of claim 1-2.

4, kind comprises the steps: as the preparation method of the arbitrary described drug regimen of claim 1-3

(1) Fructus Aurantii, that Semen Citri Reticulatae is ground into impalpable powder is standby;

(2) Oletum Trogopterori, the Radix Linderae, the Rhizoma Atractylodis Macrocephalae, Radix Salviae Miltiorrhizae, Fructus Foeniculi, Rhizoma Corydalis, Fructus Toosendan, Rhizoma Alismatis, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Myrrha, Poria decoct with water secondary, each 2 hours, filter, merging filtrate, concentrating under reduced pressure adds ethanol to 60%, leaves standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder, drying, be ground into fine powder, make granule, capsule and pill with pharmaceutically acceptable carrier.