CN101278359A - Radiopharmaceutical system and method utilizing radio-frequency identification tags - Google Patents
Radiopharmaceutical system and method utilizing radio-frequency identification tags Download PDFInfo
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- CN101278359A CN101278359A CNA2006800368356A CN200680036835A CN101278359A CN 101278359 A CN101278359 A CN 101278359A CN A2006800368356 A CNA2006800368356 A CN A2006800368356A CN 200680036835 A CN200680036835 A CN 200680036835A CN 101278359 A CN101278359 A CN 101278359A
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Abstract
The invention, in one characterization, may be said to be directed to a radiopharmaceutical system. In some embodiments, the system may include a radioisotope elution component and a radio-frequency identification (RFID) tag coupled to the radioisotope elution component. Other embodiments may include a radiation shielded enclosure having an interior, an exterior, and a radio-frequency identification (RFID) communication transmission passage extending between the interior and the exterior.
Description
Technical field
The present invention relates generally to the field of nuclear medicine.More especially, the present invention relates to management and/or tracking and at least a radioactive shield device (for example, radiopharmaceutical container or generator) and be arranged at wherein the relevant information of radioactive material (for example, radiopharmaceutical).
Background technology
The purpose of this part be to reader's briefing with introduce below and/or the various aspects of the technology that the each side of the present invention of claim is relevant.Thereby this part is introduced and to be believed and can help to be convenient to better understand various aspects of the present invention for the reader provides background information.Therefore, should understand these statements from then on angle reading, rather than to the approval of prior art.
The field of nuclear medicine is used for diagnosis and therapeutic purposes by the radioactive material of the suitable dose that can concentrate in the certain organ of patient or biotic district for patient infusion with radioactive material.The radioactive material that is generally used for the field of nuclear medicine is comprising technetium-99m, indium-111 and thallium-201.Some radioactive material is naturally in specific set of organizations, and for example, iodine is concentrated to thyroid gland.Other radioactive material can be looked for the agent combination with sign or organ that the organ or the biotic district that make radioactive material with patient's expectation are target.These separately or with the radioactive material of sign agent combination in the so-called radiopharmaceutical of the field of nuclear medicine.Under the situation of the relatively low dosage of radiopharmaceutical, radiophotography system (for example, gamma camera) provides the image of radiopharmaceutic organ of accumulation or biotic district.The situation of the irregular usually prompting morbid state in the image, for example cancer.The radiopharmaceutical of higher dosage can be used for directly pathological tissues, such as cancer cell, and the radiation of the dosage for the treatment of.
There are multiple systems and device to be used for producing, to transport, distribute and the management radiopharmaceutical.Typical radiopharmaceutical technology chain can comprise that manufacturing/assembling (for example is used to hold parent radioactive material, molybdenum-99) radioisotope generator assembly, the radioisotope generator assembly is transported to radiopharmacy, from radioisotope generator assembly elution filial generation radioactive material (for example, technetium-99m) (for example to the shielded eluate out-put container, reagent bottle), carry out-put container from shielding Xian and to means (for example draw one or more dosage to one or more patients, single-dose syringe), at the radioactive shield assembly (for example, medicine box) in the patient is delivered to medical institutions to means, and uses the patient to give single dosage in the means the patient.This technology chain can also comprise that with one or more dosage and kit for example, sign or organ are looked for agent and mixed.In addition, this technology chain can comprise that the organ to being located by radiopharmaceutical carries out imaging, based on radiopharmaceutic concentration/distribution diagnosis patient in this certain organs.Manufacturing/assembling for radioactive isotope emitter assembly, this technology as the accessory substance of nuclear fission (for example can specifically comprise, the uranium fission accessory substance) or by using particle accelerator (for example, cyclotron) production parent radioactive material (for example, molybdenum-99), radioactivity parent material is constrained in aluminium oxide (Al
2O
3) pearl or resin-column, in alumina bead or resins exchange column such as radioactive shield generator, and the radioactive shield generator is placed in the auxiliary screen.For elution, this technology can specifically comprise in the radiotropism isotope cow provides scrub solution (for example, brine solution), in eluant, produce eluate thereby from aluminium oxide or resin-column, wash out or dissolve the filial generation radioactive material, and the output eluate is in the shielding out-put container.
Consider radiopharmaceutic radioactivity, serviceable life, statistical measurement or the like, follow the tracks of and write down for the step particular importance in said system, device and the technology chain.Do not luckily have and be, in generation, transportation, distribution with between the operating period, radiopharmaceutical is placed in the opaque radiation shielded container usually, therefore, temporary transient at least obstruction during those steps of technology, be directly acquainted with radiopharmaceutical (and information) in the container.In addition, during radiopharmaceutical each step in technology, radiopharmaceutical will move to another from a container, has therefore increased the complicacy that expectation information is followed the tracks of and write down.Usually, with radiopharmaceutical and/or be used for the tracking of the relevant information of its radiation shielded container and record by hand-written record and/or realize by hand to computing machine input data.Thus, the information that is associated with particular radiopharmaceutical system, device or technology is difficult for obtaining.As a result, follow the trail of specific radiopharmaceutical and get back to quite difficulty and/or time-consuming of the original manufacturing plant relevant, means of transport, radiopharmacy, system or device with radiopharmaceutical.
Summary of the invention
The present invention is by instructing a kind of being arranged on such as radio-frequency (RF) identification (RFID) label on one or more radiopharmaceutical agent devices of container, radiation shield, radioisotope generator and radioisotope elution system in a particular embodiment.Particularly, in certain embodiments, the RFID label can be coupled in radioisotope generator, eluant supply container, elution out-put container or be arranged on one or more these parts one or more radiation shields on every side.In certain embodiments, the RFID communication transmission passage can be passed through the radiation shielding material extension such as the other parts of sidewall, cover plate or radiation shield or outer cover.In addition, the RFID communication transmission passage of some embodiment can have the bending or the angle of edge a plurality of directions one by one.In addition, the RFID communication transmission passage of some embodiment can be formed by magnetic material.
List below with the corresponding particular aspects of the scope of the initial claim of the present invention.Should be understood that these aspects only are for the brief overview of the particular form that can adopt the present invention is provided to the reader, and these aspects should not limit the scope of the invention.In fact, the present invention can comprise can be not the following various features of listing and aspect.
According to a first aspect of the invention, provide a kind of radiopharmaceutical system, radio-frequency (RF) identification (RFID) label that it can comprise radioisotope elution component and be coupled in radioisotope elution component.Herein, " radioisotope elution component " generally is meant any parts (for example, being connected in the parts of radiation shielding structure during radiation shielded components or any setting part that radioisotope elution is handled in or at least in) that are designed in radioisotope elution is handled.For example, in the specific embodiment that is described in detail below, radioisotope elution component can comprise radioisotope generator, eluant supply container, elution out-put container, radiation shielding structure or its combination.
According to a second aspect of the invention, provide a kind of radiopharmaceutical system, it can comprise the radioisotope generator assembly and be arranged on radio-frequency (RF) identification (RFID) label on the part of radioisotope generator assembly.
According to a third aspect of the invention we, provide a kind of radiopharmaceutical system, it can comprise radiation shielded enclosure, radio-frequency (RF) identification (RFID) communication transmission passage that radiation shielded enclosure has inside, outside and extends between inside and outside.
According to a forth aspect of the invention, provide a kind of radiopharmaceutical system, it can comprise the elution output precision and be arranged on radio-frequency (RF) identification (RFID) label on the part of elution output precision.Elution out-put container and the connection of radioisotope generator fluid that the elution output precision can comprise radiation shielded enclosure, wash out.In a particular embodiment, expression fluid connects and can represent first parts are connected in second parts, perhaps connect one or more parts that can be connected in second parts, perhaps connect the mechanism of first parts to the part of the system that comprises second parts, make material (for example, liquid or gas) molecule can remain in the system substantially, can in the system that comprises first and second parts, circulate simultaneously.For example, the radioisotope generator fluid connects the mechanism that can comprise one or more discharge elution out-put containers and/or radioisotope generator, wherein this mechanism is constructed so that and can exchanges between elution out-put container of discharging and radioisotope generator or circulation material (for example, gas or liquid).
According to a fifth aspect of the invention, a kind of method is provided, it can be drawn together in the radioisotope generator of radiotropism isotope elution system and supply with eluant, radioactive isotope in the radioisotope generator, from radioisotope generator, export eluant, and with the one or more parts that are arranged on radioisotope elution system on one or more radio-frequency (RF) identification (RFID) label communication data.
Can improve about each feature of various aspects of the present invention above.Further feature also can be combined in these various aspects.These features and extra feature can independence or combination in any existence.For example, below can independence or being attached in the above-mentioned aspect of any the present invention of combination in any about each features of one or more illustrated embodiment introductions.The brief overview that proposes equally, above only should be to make the reader be familiar with particular aspects of the present invention and content and claim essence is not construed as limiting.
Description of drawings
Read with reference to accompanying drawing and followingly to introduce in detail, will make feature of the present invention, aspect, and advantage be better understood, in the accompanying drawing, identical Reference numeral is represented identical parts all the time, wherein:
Fig. 1 is the skeleton diagram with exemplary embodiment of the radiation shield communication system of passing radio-frequency (RF) identification (RFID) communication transmission passage that radiation shield cover extends;
Fig. 2 is the local skeleton diagram of the radiation shield communication system of Fig. 1, shows by the signal of communication in RFID read/write device outside the radiation shield cover and the RFID communication transmission passage between the RFID label of radiation shield cover inboard;
Fig. 3 is the decomposition diagram with exemplary embodiment of the radioisotope elution system that is positioned at the RFID label on radioisotope generator, eluant supply container and the elution output precision;
Fig. 4 is the side cross-sectional view of the radioisotope elution system embodiment of Fig. 3, shows to pass to be positioned at the RFID communication transmission passage that radioisotope generator, eluant supply container and elution output precision essential part auxiliary radiation shield is on every side extended;
Fig. 5 is the side cross-sectional view of another embodiment of radioisotope elution system of Fig. 3, shows the RFID communication transmission passage of passing the lid extension that is positioned at radioisotope generator, eluant supply container and elution output precision essential part auxiliary radiation shield on every side;
Fig. 6 is the side cross-sectional view of another embodiment of radioisotope elution system of Fig. 3, show the RFID read/write device that is positioned at auxiliary radiation shield, wherein the radiopharmacy management system of RFID read/write device line outside being positioned at auxiliary radiation shield;
Fig. 7 is the side cross-sectional view of another embodiment of radioisotope elution system of Fig. 3, show the RFID read/write device that is positioned at auxiliary radiation shield, wherein the RFID transponder of RFID read/write device line outside being positioned at auxiliary radiation shield is used for and the radiopharmacy management system wireless communications;
Fig. 8 is the partial side sectional view of another embodiment of radioisotope elution system of Fig. 7, show the elution output precision that partly exposes with respect to radioisotope generator, wherein the radiation shield cover removably is arranged at RFID communication transmission passage top in the elution output precision;
Fig. 9 is the partial side sectional view of the radioisotope elution system of Fig. 8, shows the elution output precision that is coupled in radioisotope generator, and wherein the RFID communication transmission passage does not cover with the radiation shield cover;
Figure 10 is the side cross-sectional view of alternative embodiment of the elution output precision of Fig. 3, shows to pass the elution output precision at the head with RFID read/write device and hold the RFID communication transmission passage of extending between the inner chamber of the eluant out-put container with RFID label;
Figure 11 is the side cross-sectional view of alternative embodiment of the elution output precision of Fig. 3, shows to pass the elution output precision at the RFID read/write device on the head and holding the RFID line that extends between the RFID read/write device in the inner chamber of the eluant out-put container with RFID label;
Figure 12 is the skeleton diagram of exemplary embodiment with radiopharmaceutical information trace system of the RFID label that is positioned on various radiopharmaceutical supply, generator part and the radiopharmaceutical products, and wherein RFID read/write device is used at manufacturing plant, means of transport, radiopharmacy and other position and these RFID label communications;
Figure 13 is the block scheme that the exemplary embodiment of the radiopharmaceutical that adopts exemplary radioisotope elution system of the present invention or system is shown; And
Figure 14 is the structural drawing that exemplary embodiment that utilize to use the radiopharmaceutic nuclear imaging system that exemplary radioisotope elution system of the present invention obtains is shown.
Embodiment
To introduce one or more specific embodiment of the present invention below.For the succinct introduction to these embodiment is provided, can in instructions, not introduce all features of practical application.Should understand, in the exploitation of any this practical application,, must carry out a large amount of concrete application according to developer's specific purposes and change as in any engineering or planned design, such as the relevant and commercial relevant restriction of obedience system, this is different for different application meetings.In addition, it should be understood that these development meeting relative complex and consuming time, but only be the routine business that designs, constructs, makes by content disclosed herein to those skilled in the art.
Fig. 1 shows the radiation shield communication system 10 of example, and it has radio-frequency (RF) identification (RFID) communication transmission passage or path 12 that radiation shielded enclosure of passing 14 is extended.RFID label 16 can be arranged on the radiopharmaceutical container 18 of enclosed cavity 20 of radiation shielded enclosure 14, and RFID read/write device 22 can be arranged on outside the radiation shielded enclosure 14.Radiopharmaceutical container 18 can comprise (for example, load) various containers or device, is used for the supply relevant with nuclear medicine, generation, processing, distribution, transportation or medical application radiopharmaceutical.For example, radiopharmaceutical container 18 can comprise medicine bottle, syringe, radioisotope generator or be used for radiopharmaceutic other container.As being described in further detail below, RFID read/write device 22 is communicated by letter with RFID label 16 through RFID communication transmission passage or path 12, under radioactive structure that can stop substantially or hold in the radiation shielded enclosure 14, this can help communicating by letter and message exchange between RFID label 16 and the RFID read/write device 22.For example, RFID communication transmission passage 12 can by can make the RFID signal by but the material that substantially radioactive ray is passed through form or have such geometric configuration.
For the embodiment of following introduction, data can comprise radioisotope generator data, radiation shield data, eluant data, eluate data, elution process data, sign agent data and/or with parts or other relevant data of program of radioisotope elution system.For example, radioisotope elution data can comprise radioactive level, elution process time, elution process duration, be used for the identity of the radioisotope generator of elution process, the identity that is used for the elution out-put container of elution process, the size of elution out-put container that is used for elution process and/or the vacuum level of elution out-put container.The data that are stored on each RFID label can be used in certain location or place the part, and/or data can be shared between each place.For example, data can exchange between each place through network, and/or data can exchange between the delivery period between each place at the article with RFID label.
In a particular embodiment, RFID label 16 can comprise various active or passive transceiver, its have band radio frequency (RF) circuit integrated circuit and be used for the storer of data storage.Active RFID tag 16 can comprise that being used for oneself is the internal battery of circuit supply, and passive RFID tags 16 can obtain power supply from RFID read/write device 22.Compare with active RFID tag 16, passive RFID tags 16 can have littler and lighter form relatively, longer life-span, and shorter communication range.In certain embodiments, RFID label 16 can be have silicon microprocessor, structure as the wire coil of antenna and be wrapped in microprocessor and coil around the inductive coupling RFID label 16 of outer closure material (for example, glass or polymkeric substance).Inductive coupling RFID label 16 can be by the magnetic field power supply that produces by RFID read/write device 22.For example, the wire coil of inductive coupling RFID label 16 can receive magnetic energy and with RFID read/write device 22 swap datas.In other embodiments, RFID label 16 can be have the silicon microprocessor, structure is as the conductive carbon ink of antenna and capacitively-coupled rfid label 16 with paper (for example, paper is signed) of viscosity.For example, microprocessor can be connected in the printed carbon ink water electrode on the adhesive label.Compare with inductive coupling RFID label 16, capacitively-coupled rfid label 16 can have more dirigibility relatively and cost is lower.
RFID read/write device 22 can comprise various be configured to transmit and receive the electromagnetism in radio frequency in the electromagnetic wave spectrum (RF) part or the transceivers of electrostatic signal.RFID label 16 can change according to a plurality of factors to some extent with the scope of RFID read/write device 22, comprises frequency, medium or the like.In some alternative embodiment, RFID read/write device 22 can substitute with one or more devices, and wherein each device in those devices can only read or write to it from RFID label 16.In other alternative embodiment, label 16 and read/write device 22 can comprise the another kind of form that is used for short range communication (DSRC) or smart tag technology.
RFID communication transmission passage 12 can be limited in one or more positions of passing radiation shielded enclosure 14.In certain embodiments, RFID communication transmission passage 12 can be positioned at tightly near the height or the general location that are arranged on the RFID label 16 on the radiopharmaceutical container 18.This near the position, RFID read/write device 22 can be communicated by letter with RFID label 16 through RFID communication transmission passage 12 more effectively.RFID communication transmission passage 12 can have the guiding electromagnetic energy to outer cover 14 more away from the route in primary radiation source.For example, if the bottom of the close outer cover 14 of main gamma emitter, then the RFID communication transmission passage can be extended towards the top of outer cover 14.
Still with reference to Fig. 1, the cup-like portion 24 that RFID communication transmission passage 12 can be arranged on radiation shielded enclosure 14 is the position of feature.Cup-like portion 24 can comprise such as cylindrical vessel, have the container 26 by the opening of lid or 28 coverings of cover plate part.Perhaps, RFID communication transmission passage 12 can be arranged in lid or the cover plate part 28.Thereby cover plate part 28 can remain on container 26 tops (for example, covering the opening enter container) substantially prevent that substantially radiation is by the outer cover 14 of escaping out of the opening in the container 26.Thus, cup-like portion 24 and cover plate part 28 combine, and can be used for comprising basic restriction radiation exposure under the radiopharmaceutic situation of use.For example, radiopharmaceutical container 18 can keep and is enclosed in the radiation shielded enclosure 14, thereby is used for storing or transporting the possibility that reduces radiation exposure.
In a particular embodiment, the user may wish through RFID label 16 and 22 visits of RFID read/write device, storage, revise or data that general exchange and radiopharmaceutical container 18 are relevant.For example, be desirable directly with radiopharmaceutical container 18 storages and visit data (for example, increasing efficient and the accuracy that comprises manufacturing, transportation/tracking, radioisotope elution or examine medical processing).If cover plate part 28 or radiopharmaceutical container 18 are taken away from radiation shielded enclosure 14, then RFID read/write device 22 can be communicated by letter and exchange message with the RFID label 16 on being arranged on container 18.Yet, if radiopharmaceutical container 18 is enclosed in the enclosed cavity of radiation shielded enclosure 14, then RFID communication transmission passage 12 can be convenient to communicating by letter and message exchange between RFID label 16 and the RFID read/write device 22 according to reducing possible mode that radiation escapes from radiation shielded enclosure 14.For example, the geometric configuration of RFID communication transmission passage 12, material composition and further feature can allow effective RFID to communicate by letter, and reduce the possibility that radioactive ray is escaped by passage 12 simultaneously.
Fig. 2 shows can be by the signal of communication (for example, electromagnetism or static) or the exchanges data 30 of the RFID communication transmission passage 12 between RFID label 16 and the RFID read/write device 22.RFID communication transmission passage 12 can comprise various radio-frequency transmissive materials, such as iron or other magnetic material 32.By more low-impedance route (for example, low magnetic resistance route) is provided, magnetic material 32 can be so that through radiation shielded enclosure 14 directs communication signals 30 (for example, electromagnetism or static).In this way, RFID communication transmission passage 12 can be similar to and make current through pipeline ground guiding electromagnetic energy or it is flow through.
The sensing of RFID communication transmission passage 12 can make radioactive ray to stop substantially before arriving radiation shielded enclosure 14 outsides or to eliminate by changing along route 12 a plurality of corners, curve or direction one by one.For example, horizontal alignment 34, intermediate vertical 36 and outer horizontal alignment 38 in RFID communication transmission passage 12 can comprise.In other words, inside and outside horizontal alignment 34 and 38 can be basically perpendicular to the surfaces externally and internally 40 and 42 of the cup-like portion 24 of radiation shielded enclosure 14, and intermediate vertical 36 can be substantially parallel and between the surfaces externally and internally 40 and 42 of cup-like portion 24.Yet, in other embodiment of RFID communication transmission passage 12, can use various other geometric configuratioies and structure.For example, the geometric configuration of RFID communication transmission passage 12 can be curve, bending, broken line and/or the direction that changes process cup-like portion 24 substantially, makes that changing direction can stop radioactive ray.More usually, the geometric configuration of the RFID communication transmission passage 12 among some embodiment can be said non-linear and/or on-plane surface.In certain embodiments, the inside surface of RFID communication transmission passage 12 can have the superficial makings such as peak and paddy pattern, can the block radioactivity inside surface.Yet other embodiment of RFID communication transmission passage 12 can have smooth inside surface, and extends through radiation shielded enclosure 14 straight.For example, RFID communication transmission passage 12 can be rod or cylinder class shape.
Still with reference to Fig. 2, the magnetic material 32 of RFID communication transmission passage 12 makes signal of communication 32 freely to flow through between surfaces externally and internally 40 and 42 or to pass through, and the radiation shielding material 44 of radiation shielded enclosure 14 stops from the signal of RFID read/write device 22 and RFID label 16 or communicates by letter, as arrow 46,48,50 and 52.Similarly, the radiation shielding material 44 of radiation shielded enclosure 14 can stop the radioactivity from radioactive source 54 substantially, shown in arrow 56,58,60 and 62.In a particular embodiment, radiation shielding material 44 can comprise lead, tungsten, depleted uranium or other shielding material that is fit to.Although the magnetic material 32 of RFID communication transmission passage 12 can be propagated along linear direction from the radioactive ray 60 and 62 of radioactive source 54, regardless of magnetic material 32 substantially along a plurality of directions by RFID signal of communication 30.Magnetic material 32 can provide some radiation shields of resisting radioactive ray 60 and 62, and intermediate vertical 36 can reduce the possibility that radioactive ray 60 and 62 can pass through to surpass interior horizontal alignment 34.In other embodiments, RFID communication transmission passage 12 can have the circuit of other geometric configuration or a plurality of directions, such as L shaped, M shape, N shape, S shape, U-shaped, V-arrangement, W shape or Z-shaped.In addition, specific embodiment can be included in a plurality of passages of radiation shielded enclosure 14 various pieces.In addition, RFID communication transmission passage 12 can be in the primary radiation source at a distance or away from the primary radiation source, thereby reduce radiation from outer cover 14 escape from may.Thus, the length of intermediate vertical 36 can be extended (for example, the essential part of outer cover 14 height) thereby be increased distance between radiation source and the outer horizontal path 38.
Fig. 3 shows exemplary radioisotope elution system 70, and it can have according to the present technique specific embodiment and is arranged on RFID label on each parts.Radioisotope elution system 70 can comprise elution output precision 72 and radioisotope generator assembly 74.Shown radioisotope generator assembly 74 can comprise radioisotope generator 76, eluant supply container 78 and have inner chamber or cave in 82 and be engaged in the auxiliary radiation shield 80 of the cover plate 84 of shielding on 80 split sheds 86.In the embodiment shown, radioisotope elution system 70 can comprise the RFID label 88 that is arranged on the elution output precision 72, is arranged on the RFID label 90 on the radioisotope generator 76 and is arranged on RFID label 92 on the eluant supply container 78.Yet extra RFID label can be incorporated on other parts of radioisotope elution system 70.In addition, thus the various RFID read/write device and the various communication technology can be incorporated into radioisotope elution system 70 is convenient to be used for the relevant exchanges data of each parts.
Still with reference to Fig. 3, radioisotope generator 76 can be reduced in the depression 82 of auxiliary radiation shield 80, shown in arrow 94.Similarly, 98 of eluant supply container 78 can be reduced on the hollow output syringe needle 100 in the inputs depression 102 of radioisotope generator 76, shown in arrow 96.In a particular embodiment, input depression 102 can have the closely cooperate geometric configuration of eluant supply container 78 outside surfaces 104 of size, makes eluant supply container 78 to import to basic center towards hollow output syringe needle 100 downwards.In certain embodiments, in the inner chamber of auxiliary radiation shield 80 or cylindrical recesses 82, radioisotope generator 76 and eluant supply container 78 are installed after, cover plate 84 can drop on the opening 86.As mentioned above, there is not the assembly of elution output precision 72 can be called radioisotope generator assembly 74.In addition, when storage or transportation radioisotope generator assembly 74, radioisotope generator assembly 74 can comprise the radiation shielded plug in the path 10 6 that is arranged in the cover plate 84.
In the embodiment shown in fig. 3, elution output precision 72 can be through the path 10 in the cover plate 84 6 and radioisotope generator 76 couplings (for example, taking off radiation shielded plug after (not shown)).For example, the path 10 6 in the cover plate 84 can be aimed at the output depression 108 in the radioisotope generator 76 substantially.Be similar to input depression 102, output depression 108 can comprise hollow output syringe needle 110 in the position of output depression 108 approximate centre.If expectation is from radioisotope generator 76 elutions, then radiation shielded plug can take off and with shown in elution output precision 72 replace.Therefore, elution output precision 72 can descend at least in part and combine with hollow output syringe needle 110 in the radioisotope generator 76 in the auxiliary radiation shield 80 through path 10 6, shown in arrow 112.Be similar to input depression 102, output depression 108 can have the geometric configuration of size of the outside surface 114 of the elution output precision 72 that closely cooperates, and makes the elution output precision to combine with hollow output syringe needle 110 along basic center position guiding.
Fig. 4 shows the radiopharmaceutical or the radiopharmaceutical agent infosystem 118 of the example that comprises radioisotope elution system 70.As show that RFID communication transmission passage 120 can be extended by the part of auxiliary radiation shield 80 between inner chamber 82 and outside surface 122.In this exemplary embodiment, auxiliary radiation shield 80 comprise be arranged on one by one the basis on 125 a plurality of stepped annular structures or encircle 124.Although RFID communication transmission passage 120 can have various geometric configuratioies and structure, shown in passage 120 have interior horizontal alignment 126, intermediate vertical 128 and outer horizontal alignment 130.Shown in circuit 126,128 and 130 can extend through one or more rings 124.As show that interior horizontal alignment 126 is arranged in the ring 124, and outer horizontal alignment 130 is arranged in the adjacent ring 124, thus and adjacent two rings 124 of intermediate vertical extend past connect horizontal alignment 126 and 130.In alternative embodiment, the RFID communication transmission passage 120 of Fig. 4 can have various other straight lines, angle, bending or roughly a plurality of direction (for example, non-linear) geometric configuration, and it can reduce the possibility that allows radioactive ray to pass through passage 120.In addition, RFID communication transmission passage 120 can also be formed by various iron, magnetic or other material, and it provides more low-impedance circuit (for example, low magnetic resistance circuit), and this can form electromagnetic energy or the signal effective passage by auxiliary radiation shield 80.
The radiopharmaceutical agent infosystem 118 of Fig. 4 can comprise the radiopharmacy management system 132 that communicates to connect in the RFID communicator of for example RFID read/write device 134 (or other can from data label electromagnetism and/or static reading of data and/or to the device that wherein writes data).In other words, the RFID communicator, for example the read/write device 134, can only read or only write or read and write data on the RFID label.Thus, in following introduction and claim, term RFID communicator and RFID read/write (R/W) device can use all the time mutually with exchanging.In addition, in the disclosed embodiment, phrase communicates to connect and can comprise wireless and/or wired connection and/or communication between receiving system or the device.For example, communication connecting system or device can directly connect through optical cable, insulated conductor etc.In addition, communication connecting system or device can be through infrared signal, radio frequency (RF) signal or the another kind of wireless technology swap datas that is fit to.
RFID read/write device 134 can be arranged near the RFID communication transmission passage 120.Introduce with reference to Fig. 1 and 2 as top, the RFID read/write device 134 of Fig. 4 can be through RFID communication transmission passage 120 and the RFID label 88,90 and 92 signal of communication and the swap datas that are separately positioned on elution output precision 72, radioisotope generator 76 and the eluant supply container 78.In addition, as following detailed introduction, RFID read/write device 134 can be through RFID label 138 signals of communication and the swap data 136 on passage 120 and the elution out-put container 140 that is arranged in the elution output precision 72.In this way, radiopharmacy management system 132 can be at each stage and each parts (for example, elution output precision 72, elution out-put container 140, radioisotope generator 76 and eluant supply container 78) swap data 136 of transportation, production and last nuclear medicine procedure.
Still with reference to Fig. 4, radioisotope generator 76 can be connected in eluant supply container 78 and elution output precision 72 by fluid, thereby makes fluid to circulate in the radioisotope elution process.For example, eluant supply container 78 can fluid be communicated in the hollow input syringe needle 100 of radioisotope generator 76, and elution output precision 72 can fluid be communicated in the hollow output syringe needle 110 of radioisotope generator 76.In a particular embodiment, eluant supply container 78 and elution out-put container 140 can comprise that the radioisotope generator fluid is communicated with, and such as public affairs or female connectors, thereby it is configured to cooperate with radioisotope generator 76 and makes it possible to replacement fluids.The term fluidity is communicated with or fluid be communicated with can comprise various conduits, pipe, public connector, female connectors, intermediate conductor or device, make fluid can flow between receiving system or the device (for example, container 78 and 140 and radioisotope generator 76 between).Particularly, shown hollow input syringe needle 100 can pierce through eluant supply container 78 98 in flexible embolus 144, be communicated with such as diaphragm of rubber or other radioisotope generator fluid that is fit to.Similarly, hollow output syringe needle 110 can pierce through elution output precision 72 elution out-put container 140 146 in elastic insert 144, be communicated with such as diaphragm of rubber or other radioisotope generator fluid that is fit to.Eluant supply container 78 can be pre-charged with a large amount of eluants 148, such as brine solution.The beginning, thus elution out-put container 140 can find time in container 140, to provide vacuum condition, set up the pressure difference between eluant supply container 78 and the elution out-put container 140 thus.
If expectation is from radioisotope elution system 70 elutions of Fig. 4, then can be in conjunction with one or more valves or other trigger mechanism, thereby through radioisotope generator 76 from eluant supply container 78 to the elution out-put container 140 circulation eluants 148.During elution process, eluant 148 can enter radioisotope generator 76 through one or more hollow input syringe needles 100, thereby (for example cycle through radioactive isotope that radioisotope generator 76 washes out or propose to expect, technetium-99m), and with after hollow output syringe needle 110 to elution out-put container 140 output eluant.
For example, some embodiment of radioisotope generator 76 comprises radiation shield shell (for example, plumbous shell), and it has sealed and has been adsorbed on alumina bead or the lip-deep radioactive parent of resin-column, such as molybdenum-99.In the radioisotope generator 76, parent molybdenum-99 is converted into metastable technetium-99m with 67 hours half life period.In radioisotope generator 76, daughter radioisotope, technetium-99m for example, the ratio parent radioisotope that keeps usually, for example molybdenum-99 keep not tight more.Therefore, daughter radioisotope, for example technetium-99m can utilize suitable eluant 148, and deoxidation physiological saline for example washs out or elution goes out.Elution from radioisotope generator 76 to elution out-put container 140 output generally includes eluant 148 and washs out in the radioisotope generator 76 or radioactive isotope that elution goes out.Accepted the eluant of desired amount in elution out-put container 140 after, thereby the termination circulation can be closed or throw off to valve or trigger mechanism.Introduce more in detail as following, as required, thereby the daughter radioisotope of washing out can make up diagnosis or the disposal of being convenient to patient (for example, in nuclear medicine mechanism) with the sign agent subsequently.
The eluant of collecting in elution out-put container 140 comprises radioactive isotope and the eluant that washes out.Therefore, elution output precision 72 can have the hollow radiation shielded body 150 that is arranged on around the elution out-put container 140, is convenient to limit the radioactivity that penetrates from eluant wherein thus.In addition, the upper head 152 of elution output precision 72 can comprise columniform edge 154, and it extends across the path 10 6 in the cover plate 84.Cover plate 84 can have about the wedge shape periphery of the opening in the auxiliary radiation shield 80 86 or polygonal surface of contact.For example, as shown in Figure 4, cover plate 84 can have with auxiliary radiation shield 80 in the part circular cone or the angled surface of contact 156 of opening 86.Columniform edge 154 and surface of contact 156 can provide radioactive further restriction in the auxiliary radiation shield 80.
In out of Memory, above-mentioned data can be used by certain mode, thus improve with various systems, processing, tracking of products, process efficiency and file/record that device is relevant in one or more.In a particular embodiment, the data of RFID storage can be used with information management system, such as radiopharmacy management system 132, thus the various aspects of automatic operation process and system.For example, the data of RFID storage can be so that to more effective time, volume, the concentration of each radioisotope generator 76 design and plan elution.This design and plan can be based on the amount that size and residual activity, radioisotope generator 76 with radioisotope generator 76 carry out last elution, and radioisotope generator 76 carries out the time span that experiences after the last elution and from the relevant data of attribute data of elution process before.Information management system, for example system 132, can use the data of RFID storage to create prompting or notice so that the staff carries out the elution program, comprise and wish the data that isotope cow 76 is relevant and the process steps of specific elution program.This information management system, for example system 132, can use the data of RFID storage to improve the part elution process, for example, by suitable duration and beginning/concluding time of indication elution process.The data of RFID storage make it possible to carry out performance evaluation and the reliability relevant with relevant elution component with concrete radioisotope generator 76 and follow the tracks of.
Fig. 5 shows the alternative embodiment of the radioisotope elution system 70 of Fig. 3, and it shows the RFID communication transmission passage 160 of the cover plate 84 that extends through in the auxiliary radiation shield 80.In this exemplary embodiment, horizontal path or passage 162, by-level circuit or passage 164 and outer horizontal path or passage 166 in RFID communication transmission passage 160 can comprise.In the passage 160 of or multi-direction geometric configuration non-linear at this, the radiation shielding material of cover plate 84 can stop the radioactivity from generator 76 and elution output precision 72, allows signal of communication and exchanges data between RFID read/write device 134 and RFID label 88,90,92 and 138 simultaneously.Equally, as mentioned above, radioactive ray tends to propagate along linear direction.The magnetic material of RFID communication transmission passage 160 can stop the radioactivity to small part in interior horizontal path or passage 162, the multi-direction structure of passage 160 can further reduce the basic possibility of further passing through cover plate 84 for linear radioactive ray simultaneously.In other words, be that linear radioactive ray can be by by-level circuit or passage 164 and outer horizontal path or passage 166 substantially.Compare, the magnetic material of RFID communication transmission passage 160 makes signal of communication or exchanges data 136 can pass through cover plate 84 multi-directionly.In other embodiments, RFID communication transmission passage 160 can comprise other structure and geometric shape, such as the multi-direction shape of L, M, N, S, U, V, W and Z-shaped formula.In addition, some embodiment can comprise a plurality of RFID communication transmission passage 120 and/or 160.
Fig. 6 shows the variation of the radioisotope elution system 70 of Fig. 3, it shows the RFID read/write device 170 that is arranged in 84 times auxiliary radiation shield of cover plate 80, and wherein RFID read/write device 170 is wired to radiopharmacy management system 132 through line 172.In this exemplary embodiment, RFID read/write device 170 can pass through space direct and RFID label 88,90 and 92 signal of communication or the swap datas around radioisotope generator 76, eluant supply container 78 and the elution output precision 72.Among other embodiment that is described in further detail below, RFID read/write device 170 can with RFID label 138 signals of communication or the swap data that are arranged on the elution out-put container 140, elution out-put container 140 is arranged in the hollow radiation shielded body 150 of elution output precision 72.In the embodiment shown in fig. 6, line 172 is laid along the route 174 that extends between the cover plate 84 of auxiliary radiation shield 80 and opening 86.Yet in other embodiments, route 174 can be laid between the adjacent ring 124 of auxiliary radiation shield 80 or by cover plate 84 and/or shield 80 other parts.
The another kind that Fig. 7 shows the radioisotope elution system 70 of Fig. 3 changes, and it shows additional RFID read/write device or the transponder 180 that is arranged on outside the auxiliary radiation shield 80.As show that transponder 180 can communicate to connect RFID read/write device 170 in being arranged on auxiliary radiation shield 80 through line 172.Perhaps, outside transponder 180 can be through aforesaid RFID communication transmission passage and internal RF ID read/write device 170 radio communications.In the embodiment shown, RFID transponder 180 is arranged on the cover plate 84.For example, RFID transponder 180 can or be fixed in cover plate 84 through cementing agent, screw thread, buckle and/or other installing mechanism bonding.In certain embodiments, can on a side of auxiliary radiation shield 80 or a plurality of position, one or more RFID transponders 180 be set.As shown in the figure, be used for line 172 route 174 can along or stride across the cover plate 84 of auxiliary radiation shield 80 and the surface of contact between the opening 86 extends.Perhaps, route 174 can along or stride across the interface between the adjacent ring 124 or pass auxiliary radiation shield 80 and/or the other parts of cover plate 84 are extended.Illustrated embodiment can have the radio communication device 182 that communicates to connect in radiopharmacy management system 132.In this wireless configuration, illustrated embodiment can be so that transmission of wireless signals or the exchanges data 184 between the RFID label 88,90 and 92 that is provided with in radiopharmacy management system 132 and the auxiliary radiation shield 80.
The another kind that Fig. 8 shows the radioisotope elution system 70 of Fig. 3 changes, it shows can be so that be arranged on the RFID read/write device 170 in the auxiliary radiation shield 80 and be arranged on electromagnetic communication between the RFID label 138 on the elution out-put container 140 and the mechanism 190 of exchanges data, and elution out-put container 140 is arranged in the elution output precision 72.Particularly, in the embodiment shown, mechanism 190 can comprise radiation shielded components, such as sleeve pipe 192, along or around the hollow radiation shielded body 150 of elution output precision 72 movable the setting.In a particular embodiment, radiation shielded components or sleeve pipe 192 can comprise hinge door, pivotable member, slide unit, extensible member or other switching mechanism that is fit to.Shown in mechanism 190 can comprise various guiding, fixing and slide mechanism, thereby be convenient to radiation shielded sleeve 192 along hollow radiation shielded body 150 moving up and down.
In addition, mechanism 190 can comprise one or more RFID communication transmission passage 194 by the RFID label 138 of setting on the hollow radiation shielded body 150 contiguous elution out-put containers 140.For example, RFID communication transmission passage 194 can be blank opening or Electromagnetic Launching material, such as magnetic material.Shown RFID communication transmission passage 194 can be extended straight by body 150.In other embodiments, RFID communication transmission passage 194 can have bending, angle or roughly non-linear, multi-direction geometric configuration, the geometric configuration shown in reference Fig. 1,2,4 and 5.
With during radioisotope generator assembly 74 is connected, sleeve pipe 192 can not cover or not stop RFID communication transmission passage 194 at elution output precision 72.Between the connection or installation period of the elution output precision 72 shown in arrow 196, along with the path 10 6 that elution output precision 72 passes through in the cover plate 84, the upward ring edge 198 of radiation shielded sleeve 192 can combine with the top surface 200 of cover plate 84.Last ring edge 198 can be fixed on the fixed position with radiation shielded sleeve 192, thereby and the remainder of elution output precision 72 can move down combination and fluid is communicated in radioisotope generator 76.In this way, RFID communication transmission passage 194 can become and more freely launch electromagnetic energy or signal between RFID label 138 and RFID read/write device 170.
The elution output precision 72 that Fig. 9 shows Fig. 8 is inserted into fully downwards with the hollow output syringe needle 110 of radioisotope generator 76 and combines.As shown in Figure 9, radiation shielded sleeve 192 upwards moves along the hollow radiation shielded body 150 of elution output precision 72, is arranged on respect to the not covering of RFID communication transmission passage 194 or blocking position not such as sleeve pipe 192.At this blocking position not, be convenient to RFID read/write device 170 and be arranged on electromagnetic signal between the RFID label 138 in the elution out-put container 140 in the hollow radiation shielded body 150 and the communicating by letter of data thereby RFID communication transmission passage 194 can expose.In the embodiment shown in fig. 9, radiopharmacy management system 132 can with each the RFID label 88,90,92 and 138 swap datas that are arranged on elution output precision 72, radioisotope generator 76, eluant supply container 78 and the elution out-put container 140.
Figure 10 shows the exemplary embodiment of the elution output precision 72 of Fig. 3 and 4, and it shows the RFID communication transmission passage 210 of extending to the RFID read/write device 212 on the upper head 154 that is arranged on elution output precision 72 by elution output precision 72.In the embodiment shown, RFID communication transmission passage 210 can begin at the inner chamber 214 with elution out-put container 140.For example, RFID communication transmission passage 210 can be arranged in the radiation shield part or connector 216 in the hollow radiation shielded body 150 of elution out-put container 140 tops.In a particular embodiment, RFID communication transmission passage 210 can have bending, angle, bending or roughly multidirectional geometric configuration, thereby stops that radioactive ray allows emission of RFID signal or the electromagnetic data exchange between RFID label 138 and the RFID read/write device 212 simultaneously.Shown RFID communication transmission passage 210 can comprise a pair of vertical channel or circuit 218 and 220, and its along continuous straight runs is offset and is connected in by-level passage or circuit 222.Yet passage 210 can have various other multi-direction geometric configuratioies, as mentioned above.Perhaps, passage 210 can be between RFID label 138 and RFID read/write device 212 straight or vertical extension.
Figure 11 shows another embodiment of elution output precision 72, and it shows in the hollow radiation shielded body 150 that is arranged on elution output precision 72 and the adjacent RFID read/write device 230 of RFID label 138 that is arranged on the elution out-put container 140.In addition, shown elution output precision 72 can comprise from RFID read/write device 230 and extends through radiation shield part in the hollow radiation shielded body 150 or connector 234 to being arranged on the RFID read/write device on the upper head 152 or the line of transponder 236.Therefore, can with RFID label 138 switching signals or data, simultaneously elution out-put container 140 is contained in the radiation shielding material of elution output precision 172.
Figure 12 shows the radiopharmaceutical agent information trace system 240 of example, its can have be arranged on each position with at each container relevant or a plurality of RFID read/write devices and the RFID label on the parts with radiopharmaceutical agent.As shown in the figure, radiopharmaceutical agent information trace system 240 comprises radiopharmaceutical 242, its have with transportation with receive 248 relevant RFID read/write devices 246, the RFID read/write device 250 relevant with dosage corrector 252, with extraction stand the 256 RFID read/write devices 254 of being correlated with, be arranged on the radiopharmacy management system 244 that RFID read and write-in apparatus on the radioisotope elution system 70 shown in Figure 7 or transponder 180 are communicated by letter, as shown in Figure 7.Radiopharmaceutical agent information trace system 240 can also comprise RFID read/write device 258 relevant with manufacturer 260 and the RFID read/write device 264 of being correlated with the transporter.
In a particular embodiment, radiopharmaceutical agent information trace system 240 can use one or more these RFID read/write devices 180,256,250,254,258 and 262 to obtain information, canned data or modification information, to be suitable for specific radiopharmaceutical container, parts, instrument or program.For example, the RFID read/write device 170 that radiopharmacy management system 244 can be through going through above and 180 and be arranged on RFID label 88,90,92 and 138 exchange messages on elution output precision 72, radioisotope generator 76, eluant supply container 78 and the elution out-put container 140.Radiopharmacy management system 244 can also be through network and manufacturer 260, transporter 264, medical institutions or other people or the shared information of tissue.In a particular embodiment, radiopharmacy management system 244 can use radioisotope generator data, performance information or other data to feed back to manufacturer 260 according to batch or real-time mode.
Figure 13 shows canonical system 280, is used to be provided for the syringe that having of nuclear medicine application is arranged at radiopharmaceutical agent wherein.As shown in the figure, system 280 comprises before referring to figs. 1 through 12 radioisotope elution system of introducing 70.As shown in the figure, eluant supply container 78 comprises RFID label 92, and radioisotope generator 76 comprises RFID label 90, comprises RFID label 138 and wash body container 140.Equally, RFID label 90,92 and 138 can comprise with material, origination date, initial position, validity, indication, spinoff, vessel volume, eluate data was (for example in the past, time, duration, amount, radioactive water equality), the corresponding information of transit information (for example, tracking code) or the like.System 280 shown in Figure 13 also comprises radiopharmaceutical production system 282, and its function is radioactive isotope 284 (for example, the technetium-99m solution by using radioisotope elution system 70 to obtain) is combined with sign agent 286.In certain embodiments, this radiopharmaceutical production system 282 can be called or comprise that prior art known " cartridge bag " (for example, is used to prepare the Technescan of diagnostic radioactive medicament
Cartridge bag).In the embodiment shown, sign agent 186 can also be arranged in the container with RFID label 288.Equally, the sign agent can comprise and attracted to or be the various materials of target with patient's specific part (for example, organ, tissue, tumour, cancer etc.).Therefore, RFID label 288 can comprise the information that adapts with material, origination date, initial position, validity, indication, spinoff etc.
In the work, radiopharmaceutical production system 282 produces or can be used to produce the radiopharmaceutical agent 290 that comprises radioactive isotope 284 and sign agent 286, and wherein radiopharmaceutical agent 290 can comprise RFID label 292.Shown system 280 can also comprise radiopharmaceutical agent distribution system 294, and it is convenient to radiopharmaceutical agent is drawn in the medicine bottle or syringe 296 with RFID label 298.In a particular embodiment, each parts of system 280 and function setting are in radiopharmacy, and its syringe 296 that has prepared radiopharmaceutical agent 290 is used for using in nuclear medicine application.For example, can prepare syringe 296 and be transported to medical institutions and be used for patient's diagnosis or treatment are being used.As above describe in detail, thereby one or more RFID read/write device can with RFID label 90,92,138,288,292 communicate by letter with 298 visit, storage, revise or thereby the communication information is convenient to radiopharmaceutical agent generally production, sorting and file and tracking etc.
Figure 14 shows the exemplary nuclear medicine imaging system 300 of the syringe 296 that adopt to use the radiopharmaceutical agent 290 that system shown in Figure 13 280 provides.Equally, syringe 296 can comprise RFID label 298, thereby the effective information of being convenient to adapt with radiopharmaceutical agent 290 exchanges, and makes the medical imaging program more effectively and accurately to carry out.As shown in the figure, nuclear medicine imaging system 300 comprises the radiation detector 302 with scintillater 304 and photodetector 306.The sign organ radiation emitted 309 of response in the patient 310, scintillater 304 emission light, it is by photodetector 306 inductions and be converted into electric signal.Thereby imaging system 300 can also comprise collimating apparatus radiation 308 is directly collimated towards radiation detection 302.In a particular embodiment, patient 310 can wear, carry around the medical facilities or mobile RFID label 312 (for example, wrist strap, neck band or certificate) roughly, thereby is convenient to the message exchange that adapts with patient and radiation/image forming program.For example, RFID label 312 can comprise the information that adapts with patient age, family, medical insurance, programmed emergency, emergency call connection, situation about existing in advance, medical treatment before, diagnosis, consultation doctor etc.
Shown imaging system 300 can also comprise detector acquisition circuitry 314 and image processing circuit 316.Detector acquisition circuitry 314 is roughly controlled obtaining from the electric signal of radiation detector 302.Image processing circuit 316 can be used to handle electric signal, carry out check agreement etc.Shown in imaging system 300 comprise that also thereby user interface 318 is convenient to other parts interaction of user and image processing circuit 316 or imaging system 300.As a result, imaging system 300 has produced the image 322 of patient's 310 interior label organs.As shown in the figure, image 322 can also comprise RFID label 322.For example, RFID label 322 can be pasted on the preceding or back side of image 320, thereby is convenient to the information that rapid storage and visit and image 320, patient, date, treatment conditions and scheme or other relevant information adapt.Equally, said procedure and resulting image 320 are directly benefited from system that combines RFID label and communication transmission passage and the device of introducing referring to figs. 1 through 14.
When introducing the element of the present invention or its each embodiment, article " ", " being somebody's turn to do " and " described " are to be used for expression one or more elements are arranged.Term " formation ", " comprising " and " having " are to be used to represent to comprise and represent to have listed element additional element in addition.In addition, the use of the variation of " top ", " end ", " top ", " below " and these terms is for convenience, does not need any particular orientation of parts.
Though the present invention of indubitable ground can have various changes and version, specific embodiment is that the mode according to signal illustrates and in this detailed introduction in the accompanying drawings.However, it should be understood that the present invention should not be limited to particular form disclosed herein.But the present invention should cover all modifications, the equivalence that belongs to the spirit and scope of the invention that are defined by the following claims and replace.
Claims (37)
1. radiopharmaceutical system comprises:
Radioisotope elution component; And
Be coupled in radio-frequency (RF) identification (RFID) label of radioisotope elution component.
2. radiopharmaceutical system as claimed in claim 1, wherein radioisotope elution component comprises radioisotope generator.
3. radiopharmaceutical system as claimed in claim 1, wherein radioisotope elution component comprises the eluant supply container.
4. radiopharmaceutical system as claimed in claim 1, wherein radioisotope elution component comprises the elution out-put container.
5. radiopharmaceutical system as claimed in claim 1 comprises being arranged on radioisotope elution component and RFID label radiation shielded enclosure on every side.
6. radiopharmaceutical system as claimed in claim 5 comprises the RFID communicator that is arranged in the radiation shielded enclosure.
7. radiopharmaceutical system as claimed in claim 6 comprises the RFID transponder of the outside that is coupled in radiation shielded enclosure, and wherein the RFID transponder can be coupled in the RFID communicator communicatedly.
8. radiopharmaceutical system as claimed in claim 6 comprises the radiopharmacy management system that can be coupled in the RFID communicator communicatedly.
9. radiopharmaceutical system as claimed in claim 5 comprises the RFID communication transmission passage that extends through radiation shielded enclosure along a plurality of directions one by one.
10. radiopharmaceutical system as claimed in claim 9, wherein the RFID communication transmission passage comprises magnetic material.
11. radiopharmaceutical system as claimed in claim 9 comprises being arranged on the outer RFID communicator of radiation shielded enclosure that wherein the RFID communication transmission passage makes it possible to carry out exchanges data between RFID communicator and RFID label.
12. radiopharmaceutical system as claimed in claim 5 comprises the RFID communication transmission passage that extends through radiation shielded enclosure and is movably arranged on stopping and the radiation shielded components between the blocking position not with respect to the RFID communication transmission passage.
13. radiopharmaceutical system as claimed in claim 12, wherein radiation shielded components comprises sleeve pipe.
14. radiopharmaceutical system as claimed in claim 1, wherein the RFID label comprises the radiopharmaceutical agent data, comprises calibration data or elution process data or radioisotope generator data or radiation shield data or makes data or user command data or tracking data or its combination.
15. radiopharmaceutical system as claimed in claim 1, wherein the RFID label comprises the radiopharmaceutical agent data, comprise radioactive level or elution process time or elution process duration or be used for elution process radioisotope generator identification be used for elution process the elution out-put container identification or be used for the size of elution out-put container of elution process or vacuum level or its combination of elution out-put container.
16. a radiopharmaceutical system comprises:
The radioisotope generator assembly; And
Be arranged on radio-frequency (RF) identification (RFID) label on the part of radioisotope generator assembly.
17. radiopharmaceutical system as claimed in claim 16, wherein the radioisotope generator assembly comprises the radioisotope generator that has container and be arranged on the radiation shield of the lid on the container and be arranged on container middle cover below.
18. radiopharmaceutical system as claimed in claim 16 comprises radiation shielding material and the RFID communication transmission passage that extends through radiation shielding material.
19. radiopharmaceutical system as claimed in claim 18, wherein the RFID communication transmission passage is angle or crooked between the opposite flank of radiation shielding material.
20. radiopharmaceutical system as claimed in claim 16 comprises the RFID communicator with the RFID label communication.
21. radiopharmaceutical system as claimed in claim 20 comprises the radiopharmacy management system with the RFID communication.
22. a radiopharmaceutical system comprises:
Radiation shielded enclosure, radio-frequency (RF) identification (RFID) communication transmission passage that comprises inside, outside and between inside and outside, extend.
23. radiopharmaceutical system as claimed in claim 22, wherein radio-frequency (RF) identification (RFID) communication transmission passage is one by one multidirectional bending or angle between inside and outside.
24. radiopharmaceutical system as claimed in claim 22, wherein radio-frequency (RF) identification (RFID) communication transmission passage comprises magnetic material.
25. radiopharmaceutical system as claimed in claim 22, wherein radio-frequency (RF) identification (RFID) communication transmission passage is arranged in the lid of the container part top that is arranged on radiation shielded enclosure movably.
26. radiopharmaceutical system as claimed in claim 22, wherein radiation shielded enclosure comprises the lid that is removably set on the container part top, and radio-frequency (RF) identification (RFID) communication transmission passage is arranged in the container part.
27. radiopharmaceutical system as claimed in claim 22, wherein radiation shielded enclosure comprises the radioisotope generator shielding.
28. radiopharmaceutical system as claimed in claim 22, wherein radiation shielded enclosure comprises the shielding of elution out-put container.
29. a radiopharmaceutical system comprises:
The elution output precision comprises:
Radiation shielded enclosure;
The elution out-put container of finding time; And
The radioisotope generator fluid connects; And
Be arranged on radio-frequency (RF) identification (RFID) label on the part of elution output precision.
30. radiopharmaceutical system as claimed in claim 29 comprises the RFID communication transmission passage of extending the passage radiation shielded enclosure.
31. radiopharmaceutical system as claimed in claim 30, wherein the RFID communication transmission passage is angle or bending between the inside of radiation shielded enclosure and outside.
32. radiopharmaceutical system as claimed in claim 30, wherein the RFID communication transmission passage comprises magnetic material.
33. radiopharmaceutical system as claimed in claim 30 comprises being removably set on RFID communication transmission passage radiation shielded sleeve on every side.
34. a method of using radioisotope elution system, this method comprises:
Supply with eluant in the radioisotope generator of radiotropism isotope elution system;
Radioactive isotope in the radioisotope generator;
From radioisotope generator, export eluant; And
With one or more radio-frequency (RF) identification (RFID) label communication data on the one or more parts that are arranged on radioisotope elution system.
35. method as claimed in claim 34, wherein communication data comprises the RFID communication transmission passage communication data through extending by one or more radiation shielding materials.
36. method as claimed in claim 35 is wherein linked up data and is comprised the radioactive ray that stops in one or more RFID communication transmission passage.
37. method as claimed in claim 34, wherein communication data comprises visit or stores the parts data of the one or more parts that comprise elution process data or radioisotope elution system or the data of tracking data or its combination.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72305705P | 2005-10-03 | 2005-10-03 | |
| US60/723,057 | 2005-10-03 | ||
| US60/758,168 | 2006-01-11 |
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| Publication Number | Publication Date |
|---|---|
| CN101278359A true CN101278359A (en) | 2008-10-01 |
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ID=39996581
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2006800368356A Pending CN101278359A (en) | 2005-10-03 | 2006-09-21 | Radiopharmaceutical system and method utilizing radio-frequency identification tags |
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| CN (1) | CN101278359A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104093359A (en) * | 2011-11-23 | 2014-10-08 | 通用电气公司 | Systems and methods for communicating dose calibration information |
| CN104300226B (en) * | 2014-09-29 | 2017-05-03 | 北京智谷睿拓技术服务有限公司 | Method and device for realizing directional antenna and directional antenna |
| CN112912966A (en) * | 2018-11-07 | 2021-06-04 | 通用电气健康护理有限公司 | System and method for distributed ledger management of nuclear medicine products |
-
2006
- 2006-09-21 CN CNA2006800368356A patent/CN101278359A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104093359A (en) * | 2011-11-23 | 2014-10-08 | 通用电气公司 | Systems and methods for communicating dose calibration information |
| CN104300226B (en) * | 2014-09-29 | 2017-05-03 | 北京智谷睿拓技术服务有限公司 | Method and device for realizing directional antenna and directional antenna |
| CN112912966A (en) * | 2018-11-07 | 2021-06-04 | 通用电气健康护理有限公司 | System and method for distributed ledger management of nuclear medicine products |
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Open date: 20081001 |