CN101264261A - Chinese medicine for treating pruritus and preparation thereof - Google Patents

Abstract

The invention discloses a Chinese herbal medicine for curing pruritus and the preparation method, comprising the Chinese herbal medicines with the following weight proportion: gentian 5 to 20 weight shares, scutellaria 5 to 30 weight shares, gardenia 5 to 30 weight shares, Oriental Waterplantain Rhizome 5 to 30 weight shares, plantain seed 5 to 30 weight shares, talcum 5 to 30 weight shares, angelica sinensis 5 to 20 weight shares, coix seed 5 to 20 weight shares, weeping forsythia 5 to 20 weight shares, and radix glycyrrhizae 5 to 20 weight shares. The Chinese herbal medicine has the functions of clearing liver, benefiting bile, drying dampness, relieving itching, heat-clearing and detoxifying, and is used for curing symptoms such as yellow and smelly fluor and vulvar pruritus of women or turbid urine, external genital polyhidrosis, pain and swelling and scrotal pruritus caused by downward flow of damp-heat in liver gallbladder.

Description

Chinese medicine of treatment pruritus and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine and preparation method thereof, particularly relate to a kind of Chinese medicine for the treatment of pruritus and preparation method thereof, belong to the novel technique field.

Background technology

Pruritus is one of clinical common skin disease, is a kind of no former breakout, but is a kind of dermatosis of main clinic symptoms with the skin pruritus.

Scrotal pruritus and female vulva pruritus are common clinical, and its paathogenic factor is more, and be heavy then illing skin occurs and damage, infect, swell and ache etc., brings painful topic to the patient.

At present, clinical treatment scrotal pruritus, woman's property pruritus vulvae adopt the medicine external treatment more, though but respite pruritus symptom can't effect a radical cure, very easily the recurrence, bring very big misery to the patient.

The traditional Chinese medical science is thought, scrotal pruritus and woman's property pruritus vulvae endogenous cause of ill are many to be caused by dampness-heat in the liver and gallbladder, exopathogenic factor is then many by due to diabetes, endocrine disturbance and the bad life habits, should keep the affected part health on the one hand in the treatment, need dialectical opinion to control on the other hand, adopt the method for outer sick treatment by oral administration of medicines, with the conditioning human body function equilibrium, reach the purpose for the treatment of both the principal and secondary aspects of a disease, the exploitation of this type of medicine is significant for improving level of human health and quality of life.

Summary of the invention

One of the object of the invention is to provide a kind of Chinese medicine for the treatment of pruritus, and this product has liver heat removing function of gallbladder promoting, dampness removing to stop itchin, the effect of heat-clearing and toxic substances removing, be used for the treatment of dampness-heat in the liver and gallbladder make a bet due to scrotal pruritus, swell and ache, polyhidrosis around the external genitals, stranguria with turbid discharge, or women's pudendum scabies is overworked, yellow smelly disease, the definite effect of waiting of leukorrhagia.

Two of the object of the invention is to provide this preparation method of Chinese medicine.

The present invention is in conjunction with the modern Chinese medicine theory, on clinical practice experiential basis for many years, sum up the etiology and pathogenesis of syndrome of dampness-heat of liver and gallbladder, selected have liver heat removing function of gallbladder promoting, dampness removing to stop itchin, a Chinese crude drug of the merit of heat-clearing and toxic substances removing, through the science compatibility, the pure Chinese medicine with extensive therapeutic effect that develops in conjunction with modern preparation technique, is processed into the arbitrary dosage form of oral tablet, capsule, granule of being convenient to wide clinical application.

The Chinese medicine of treatment pruritus provided by the present invention is to be made by the Chinese crude drug of following weight proportioning:

Radix Gentianae 5～20 weight portion Radix Scutellariaes 5～30 weight portions

Fructus Gardeniae 5～30 weight portion Rhizoma Alismatis 5～30 weight portions

Semen Plantaginis 5～30 weight portion Talcums 5～30 weight portions

Radix Angelicae Sinensis 5～20 weight portion Semen Coiciss 5～20 weight portions

Fructus Forsythiae 5～20 weight portion Radix Glycyrrhizaes 5～20 weight portions

Further, the Chinese medicine of treatment pruritus provided by the invention, its medicine are formed the Chinese crude drug that can be adopted as the following weight proportioning especially and are made:

Radix Gentianae 15 weight portion Radix Scutellariaes 20 weight portions

Fructus Gardeniae 20 weight portion Rhizoma Alismatis 20 weight portions

Semen Plantaginis 15 weight portion Talcums 10 weight portions

Radix Angelicae Sinensis 10 weight portion Semen Coiciss 10 weight portions

Fructus Forsythiae 10 weight portion Radix Glycyrrhizaes 15 weight portions

The preparation method of Chinese medicine of treatment pruritus provided by the invention, realize by the following method:

(1) get Radix Gentianae, be ground into fine powder, standby;

(2) get Fructus Gardeniae, Radix Angelicae Sinensis, Fructus Forsythiae, be ground into coarse powder, extract volatile oil with steam distillation, collect volatile oil, low temperature is placed, and is standby; Medicinal residues filter, and filtrate device is in addition collected, and is standby; Medicinal residues are standby;

(3) get Radix Scutellariae, Semen Coicis, be ground into coarse powder, measure 50%～95% alcohol reflux 2～4 times with 6～10 times, each 1～3 hour, extract pure liquid and filter merging filtrate, decompression recycling ethanol also is concentrated into the clear paste that relative density is 1.10～1.35 (50～70 ℃), and is standby; Medicinal residues are waved diffusing ethanol, and are standby;

(4) get Rhizoma Alismatis, Radix Glycyrrhizae, be ground into coarse powder, add Semen Plantaginis (decocting a drug wrapped), Talcum (decocting a drug wrapped) and step (2) and step (3) gained medicinal residues, decoct 2～3 times with 8～12 times of water gagings, each 1～2 hour, decocting liquid filtered, and merges with step (2) gained filtrate, be concentrated into relative density and be the clear paste of 1.10～1.35 (55～70 ℃), standby;

(5) get above-mentioned clear paste, Radix Gentianae medical material fine powder and volatile oil, formulation method adds pharmaceutical adjunct, molding routinely, packing, and check, promptly.

The specific embodiment

Embodiment 1

Prescription is formed:

Radix Gentianae 90g Radix Scutellariae 120g Fructus Gardeniae 120g Rhizoma Alismatis 120g

Semen Plantaginis 90g Talcum 60g Radix Angelicae Sinensis 60g Semen Coicis 60g

Fructus Forsythiae 60g Radix Glycyrrhizae 90g

Make 1000 altogether

Preparation method:

(1) get Radix Gentianae, be ground into fine powder, cross 100 mesh sieves, standby;

(2) get Fructus Gardeniae, Radix Angelicae Sinensis, Fructus Forsythiae, be ground into coarse powder, extract volatile oil with steam distillation, collect volatile oil, low temperature is placed, and is standby; Medicinal residues filter, and filtrate device is in addition collected, and is standby; Medicinal residues are standby;

(3) get Radix Scutellariae, Semen Coicis, be ground into coarse powder,, extract pure liquid and filter with 10 times of amount 75% alcohol reflux 2 hours; Medicinal residues add 10 times of amount 75% alcohol reflux 2 hours, extract pure liquid and filter; Medicinal residues add 10 times of amount 75% alcohol reflux 2 hours again, extract pure liquid and filter; The amalgamation liquid filter, decompression recycling ethanol also is concentrated into the clear paste that relative density is 1.30 (55 ℃), and is standby; Medicinal residues are waved diffusing ethanol, and are standby;

(4) get Rhizoma Alismatis, Radix Glycyrrhizae, be ground into coarse powder, add Semen Plantaginis (decocting a drug wrapped), Talcum (decocting a drug wrapped) and step (1) and step (2) gained medicinal residues, decocted 2 hours with 12 times of water gagings, decocting liquid filters; Medicinal residues add 10 times of water gagings and decocted 1.5 hours, and decocting liquid filters; Medicinal residues add 8 times of water gagings again and decocted 1 hour, and decocting liquid filters; Filtrate and step (1) gained filtrate merges, and is concentrated into relative density and is the clear paste of 1.30 (70 ℃), and is standby;

(5) get above-mentioned clear paste, mixing adds the Radix Gentianae fine powder, and mix homogeneously is made granule, drying, whole powder;

(6) get volatile oil,, spray in the granule with an amount of 95% dissolve with ethanol, dry below 60 ℃, the magnesium stearate of adding 0.4%, tabletting, coating, packing, check, promptly.

Embodiment 2

Prescription is formed:

Radix Gentianae 105g Radix Scutellariae 140g Fructus Gardeniae 140g Rhizoma Alismatis 140g

Semen Plantaginis 105g Talcum 70g Radix Angelicae Sinensis 70g Semen Coicis 70g

Fructus Forsythiae 70g Radix Glycyrrhizae 105g

Make 1000 altogether

(1) get Radix Gentianae, be ground into fine powder, cross 100 mesh sieves, standby;

(2) get Fructus Gardeniae, Radix Angelicae Sinensis, Fructus Forsythiae, be ground into coarse powder, extract volatile oil with steam distillation, collect volatile oil, low temperature is placed, and is standby; Medicinal residues filter, and filtrate device is in addition collected, and is standby; Medicinal residues are standby;

(3) get Radix Scutellariae, Semen Coicis, be ground into coarse powder,, extract pure liquid and filter with 10 times of amount 75% alcohol reflux 2 hours; Medicinal residues add 8 times of amount 75% alcohol reflux 2 hours, extract pure liquid and filter; Medicinal residues add 8 times of amount 75% alcohol reflux 2 hours again, extract pure liquid and filter; The amalgamation liquid filter, decompression recycling ethanol also is concentrated into the clear paste that relative density is 1.30 (55 ℃), and is standby; Medicinal residues are waved diffusing ethanol, and are standby;

(4) get Rhizoma Alismatis, Radix Glycyrrhizae, be ground into coarse powder, add Semen Plantaginis (decocting a drug wrapped), Talcum (decocting a drug wrapped) and step (1) and step (2) gained medicinal residues, decocted 2 hours with 12 times of water gagings, decocting liquid filters; Medicinal residues add 10 times of water gagings and decocted 1 hour, and decocting liquid filters; Medicinal residues add 10 times of water gagings again and decocted 1 hour, and decocting liquid filters; Filtrate and step (1) gained filtrate merges, and is concentrated into relative density and is the clear paste of 1.30 (70 ℃), and is standby;

(5) get above-mentioned clear paste, mixing adds the Radix Gentianae fine powder, mix homogeneously, and drying is ground into fine powder, crosses 100 mesh sieves, gets extract powder, and is standby;

(6) get volatile oil,, spray in the extract powder with an amount of 95% dissolve with ethanol, dry below 60 ℃, the magnesium stearate of adding 0.6%, packing, packing, check, promptly.

Embodiment 3

Prescription is formed:

Radix Gentianae 45g Radix Scutellariae 60g Fructus Gardeniae 60g Rhizoma Alismatis 60g

Semen Plantaginis 45g Talcum 30g Radix Angelicae Sinensis 30g Semen Coicis 30g

Fructus Forsythiae 30g Radix Glycyrrhizae 45g

Sucrose 915g

Make 1000g altogether

Preparation method:

(1) get Radix Gentianae, be ground into fine powder, cross 100 mesh sieves, standby;

(2) get Fructus Gardeniae, Radix Angelicae Sinensis, Fructus Forsythiae, be ground into coarse powder, extract volatile oil with steam distillation, collect volatile oil, low temperature is placed, and is standby; Medicinal residues filter, and filtrate device is in addition collected, and is standby; Medicinal residues are standby;

(3) get Radix Scutellariae, Semen Coicis, be ground into coarse powder,, extract pure liquid and filter with 10 times of amount 75% alcohol reflux 2 hours; Medicinal residues add 8 times of amount 75% alcohol reflux 2 hours, extract pure liquid and filter; Medicinal residues add 8 times of amount 75% alcohol reflux 2 hours again, extract pure liquid and filter; The amalgamation liquid filter, decompression recycling ethanol also is concentrated into the clear paste that relative density is 1.20 (55 ℃), and is standby; Medicinal residues are waved diffusing ethanol, and are standby;

(4) get Rhizoma Alismatis, Radix Glycyrrhizae, be ground into coarse powder, add Semen Plantaginis (decocting a drug wrapped), Talcum (decocting a drug wrapped) and step (1) and step (2) gained medicinal residues, decocted 2 hours with 12 times of water gagings, decocting liquid filters; Medicinal residues add 10 times of water gagings and decocted 1 hour, and decocting liquid filters; Medicinal residues add 10 times of water gagings again and decocted 1 hour, and decocting liquid filters; Filtrate and step (1) gained filtrate merges, and is concentrated into relative density and is the clear paste of 1.20 (70 ℃), and is standby;

(5) get above-mentioned clear paste, mixing adds Radix Gentianae fine powder, sucrose, and mix homogeneously is granulated, drying, and granulate, packing, packing, check, promptly.

Claims (3)

1, the Chinese medicine of treatment pruritus is characterized in that this Chinese medicine is to be made by the Chinese crude drug of following weight proportioning:

Radix Gentianae 5～20 weight portion Radix Scutellariaes 5～30 weight portions

Fructus Gardeniae 5～30 weight portion Rhizoma Alismatis 5～30 weight portions

Semen Plantaginis 5～30 weight portion Talcums 5～30 weight portions

Radix Angelicae Sinensis 5～20 weight portion Semen Coiciss 5～20 weight portions

Fructus Forsythiae 5～20 weight portion Radix Glycyrrhizaes 5～20 weight portions.

2, the Chinese medicine of treatment pruritus as claimed in claim 1 is characterized in that this Chinese medicine is to be made by the Chinese crude drug of following weight proportioning:

Radix Gentianae 15 weight portion Radix Scutellariaes 20 weight portions

Fructus Gardeniae 20 weight portion Rhizoma Alismatis 20 weight portions

Semen Plantaginis 15 weight portion Talcums 10 weight portions

Radix Angelicae Sinensis 10 weight portion Semen Coiciss 10 weight portions

Fructus Forsythiae 10 weight portion Radix Glycyrrhizaes 15 weight portions.

3, the preparation method of Chinese medicine of treatment pruritus as claimed in claim 1 or 2, realize by the following method:

(1) get Radix Gentianae, be ground into fine powder, standby;

(2) get Fructus Gardeniae, Radix Angelicae Sinensis, Fructus Forsythiae, be ground into coarse powder, extract volatile oil with steam distillation, collect volatile oil, low temperature is placed, and is standby; Medicinal residues filter, and filtrate device is in addition collected, and is standby; Medicinal residues are standby;

(3) get Radix Scutellariae, Semen Coicis, be ground into coarse powder, measure 50%～95% alcohol reflux 2～4 times with 6～10 times, each 1～3 hour, extract pure liquid and filter merging filtrate, decompression recycling ethanol also is concentrated into the clear paste that relative density is 1.10～1.35 (50～70 ℃), and is standby; Medicinal residues are waved diffusing ethanol, and are standby;

(4) get Rhizoma Alismatis, Radix Glycyrrhizae, be ground into coarse powder, add Semen Plantaginis (decocting a drug wrapped), Talcum (decocting a drug wrapped) and step (2) and step

(3) gained medicinal residues decoct 2～3 times with 8～12 times of water gagings, and each 1～2 hour, decocting liquid filtered, and merge with step (2) gained filtrate, are concentrated into relative density and are the clear paste of 1.10～1.35 (55～70 ℃), and are standby;

(5) get above-mentioned clear paste, Radix Gentianae medical material fine powder and volatile oil, formulation method adds pharmaceutical adjunct, molding routinely, packing, and check, promptly.