CN101255177B - Preparation of medicament-grade cane sugar by ion-exchange fibre method - Google Patents
Preparation of medicament-grade cane sugar by ion-exchange fibre method Download PDFInfo
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- CN101255177B CN101255177B CN2008100735233A CN200810073523A CN101255177B CN 101255177 B CN101255177 B CN 101255177B CN 2008100735233 A CN2008100735233 A CN 2008100735233A CN 200810073523 A CN200810073523 A CN 200810073523A CN 101255177 B CN101255177 B CN 101255177B
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- sucrose
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- medicament
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Abstract
The invention relates to a process for preparing pharmaceutical grade sucrose by ion exchange fiber technology, comprising dissolving food grade sucrose into deionized water by a weight-to-volume ratio of 1:1-100; passing cation exchange fiber, wherein the flow speed is 1d-10d/sec, and the weight ratio of cation exchange fiber and sucrose is 1:1-1000; then passing anion exchange fibre, wherein the flow speed is 1d-10d/sec, and the weight ratio of anion exchange fiber and sucrose is 1:1-1000; reducing pressure to crystallizing with the water content of 10% to obtain the product. The pharmaceutical grade sucrose prepared by the process has a low cost, can be directly used as medicine, and completely meets the demand of the physicochemical indexes prescribed in british pharmacopeia of 2000 edition.
Description
Technical field
The invention belongs to a kind of ionic exchange fibre technology and prepare the method for medicament-grade cane sugar.
Background technology
Sucrose is confectionery the most frequently used during people live, and more bound sucrose is as the application of additive, thinner, correctives and the vehicle etc. of medicine in field of medicaments.At present, at home and abroad the process for purification of sucrose probably has: absorption with macroporous adsorbent resin method, ion exchange resin exchange process, the flocculation agent precipitator method, reverse osmosis membrane filtration method etc., they respectively have advantage, and the some shortcomings part is also respectively arranged.Ion-exchange fiber is to be the fibrous material that abundant ion-exchange group is contained on matrix, surface with synthon or natural fiber.It is the method that grew up in recent years, range of application more and more widely, its principle is identical with ion exchange resin, but bigger than ion exchange resin exchange capacity, exchange velocity is fast, and exchange capacity is strong, reproduction speed is fast, the regeneration rate height, and also anion-exchange fibre also has decolorization.
Chinese patent (production method of the medicament-grade cane sugar) (patent No.: ZL200610018590.6), be to adopt ethanol water recrystallization method to prepare medicament-grade cane sugar.Adopt the method for this patent can prepare the medicament-grade cane sugar that meets the British Pharmacopoeia standard, but cost is also higher, the patentee is just providing a kind of method of further its production cost of reduction.
Summary of the invention
The technical problem to be solved in the present invention provides a kind of method that can produce the medical cane sugar that every physical and chemical index of meeting 2000 editions British Pharmacopoeias regulation requires at lower cost.
The present invention solves the problems of the technologies described above with following technical scheme:
Food grade sucrose is dissolved in the deionized water by 1: 1～100 (w/v); Cross cation exchange fibre, flow velocity is 1d～10d/sec, and cation exchange fibre and sucrose are with 1: 1～1000 (w/w); After anion-exchange fibre, flow velocity is 1d～10d/sec, the weight ratio of anion-exchange fibre and sucrose 1: 1～1000 (w/w); Concentrating under reduced pressure is to water content 10%～40% then, and crystallization gets finished product.
Medical sucrose product with method of the present invention is produced is white powder, need not pulverize, and can directly be used as medicine, and makes things convenient for pharmaceutical preparation to use.Production cost is low, and quality meets every physical and chemical index requirement of 2000 editions British Pharmacopoeia regulations fully, and refining and packing meets the GMP standard fully.The appearance of this high quality medicine sucrose provides necessary condition for ensureing people ' s health and the safe and effective of medicine, and will make sugar enterprise and pharmaceutical manufacturer obtain remarkable economic efficiency and social benefit thus.
Embodiment
The tangible benefit of ion-exchange fiber method is not need complex apparatus, and treatment process is simple, and fiber is renewable, the used bronsted lowry acids and bases bronsted lowry of regeneration can neutralize mutually, little to the harm that environment causes, so the cost of preparation sucrose is lower, the preparation method obtains promoting easily.
The ion-exchange fiber that the present invention uses is provided by Guilin Zhenghan Science ﹠. Technology Development Co., Ltd.
Embodiment 1:
0.5kg the food grade sucrose dissolved is in 10 premium on currency, cross the 50g cation exchange fibre, flow velocity is 3d/sec, crosses the 50g anion-exchange fibre then, and flow velocity is 3d/sec, be evaporated to moisture 20%, be chilled to room temperature, separate out white crystal, suction filtration, drying obtains meeting powdery medicament-grade cane sugar 425 grams that every physical and chemical index of 2000 editions British Pharmacopoeia regulation requires, and yield is 85%.
Embodiment 2:
1.0kg the food grade sucrose dissolved is in 100 premium on currency, cross the 1.0kg cation exchange fibre, flow velocity is 10d/sec, crosses the 1.0kg anion-exchange fibre then, and flow velocity is 10d/sec, be evaporated to moisture 30%, be chilled to room temperature, separate out white crystal, suction filtration, drying obtains meeting powdery medicament-grade cane sugar 805 grams that every physical and chemical index of 2000 editions British Pharmacopoeia regulation requires, and yield is 80.5%.
Embodiment 3:
8.0kg the food grade sucrose dissolved is in 8 premium on currency, cross the 8.0g cation exchange fibre, flow velocity is 1d/sec, crosses the 8.0g anion-exchange fibre then, and flow velocity is 1d/sec, be evaporated to moisture 15%, be chilled to room temperature, separate out white crystal, suction filtration, drying obtains meeting powdery medicament-grade cane sugar 712 grams that every physical and chemical index of 2000 editions British Pharmacopoeia regulation requires, and yield is 89%.
Claims (1)
1. the method for a preparation of medicament-grade cane sugar by ion-exchange fibre method, it is characterized in that with food grade sucrose by weight volume ratio be 1: 1～100 to be dissolved in the deionized water; Cross cation exchange fibre, flow velocity is 1d～10d/sec, the weight ratio of cation exchange fibre and sucrose 1: 1～1000; After anion-exchange fibre, flow velocity is 1d～10d/sec, the weight ratio of anion-exchange fibre and sucrose 1: 1～1000; Concentrating under reduced pressure is to water content 10%～40% then, and crystallization gets finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008100735233A CN101255177B (en) | 2008-04-07 | 2008-04-07 | Preparation of medicament-grade cane sugar by ion-exchange fibre method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008100735233A CN101255177B (en) | 2008-04-07 | 2008-04-07 | Preparation of medicament-grade cane sugar by ion-exchange fibre method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101255177A CN101255177A (en) | 2008-09-03 |
| CN101255177B true CN101255177B (en) | 2011-11-23 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2008100735233A Expired - Fee Related CN101255177B (en) | 2008-04-07 | 2008-04-07 | Preparation of medicament-grade cane sugar by ion-exchange fibre method |
Country Status (1)
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| CN (1) | CN101255177B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101508707B (en) * | 2009-03-25 | 2011-09-28 | 湖南尔康制药股份有限公司 | Production process for medicinal sucrose |
| CN104195271A (en) * | 2014-09-28 | 2014-12-10 | 桂林正翰科技开发有限责任公司 | Method for producing refined sugar through ion-exchange fiber high efficiency decolorization one-step method |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1336441A (en) * | 2001-09-17 | 2002-02-20 | 桂林正翰科技开发有限责任公司 | Treacle decoloring process |
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2008
- 2008-04-07 CN CN2008100735233A patent/CN101255177B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1336441A (en) * | 2001-09-17 | 2002-02-20 | 桂林正翰科技开发有限责任公司 | Treacle decoloring process |
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| CN101255177A (en) | 2008-09-03 |
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