CN101250193A - Method for preparing 2-methoxy-5-(alpha-cyclopropyl carbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothiophene [3,2-c] pyridine - Google Patents
Method for preparing 2-methoxy-5-(alpha-cyclopropyl carbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothiophene [3,2-c] pyridine Download PDFInfo
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Abstract
The invention discloses a new preparation method of 2-methoxy-5-(alpha-cyclopropyl carbonyl-2-fluorobenzyl)-4, 5, 6, 7-tetrahydrothiophene [3, 2-c] pyridine, which only needs to one step that condenses 2-methoxy-4, 5, 6, 7-tetrahydrothiophene [3, 2-c] pyridine and alpha-halogenated p-fluorine benzyl cyclopropyl ketone to obtain targe product, with mild reaction conditions, non low temperature demand, non explosive material, high yield, low cost and high efficiency. The invention is suitable for large-scale industrial production.
Description
Technical field
The present invention relates to 2-methoxyl group-5-(α-cyclopropyl carbonyl-2-luorobenzyl)-4,5,6, the 7-tetramethylene sulfide is preparation method's technical field of [3,2-c] pyridine also.
Background technology
Thrombus can make main organs generation ischemic and infraction, also can cause oedema and venous insufficiency, thereby causes various dysfunctions.Being used for clinical antithrombotic at present, to represent medicine be clopidogrel, acetylsalicylic acid and A Xi monoclonal antibody.The action intensity of clopidogrel is stronger than acetylsalicylic acid, side effect is little, clinical in-stent restenosis behind atheromatosis, acute coronary syndrome, the prevention coronary artery Stent and thrombotic complications etc. of being used for the treatment of.Prasugrel is and similar tetramethylene sulfide of clopidogrel and pyridine compounds and their that clinical three phases demonstrate activity, tolerance and the security that is better than clopidogrel, are expected to become a good antithrombotic reagent.
Chinese patent 92111584 discloses a kind of 5-(α-cyclopropyl carbonyl-2-luorobenzyl)-2-oxygen-2,4,5,6,7, the synthetic method of 7a-six hydrogen thieno-s [3,2-c] pyridine, and its synthetic route is as follows:
This method is with 2-oxygen-2,4,5,6,7,7 α-six hydrogen thieno-s [3,2-c] pyridine (formula 1 compound) and alpha-brominated adjacent luorobenzyl cyclopropyl ketone (formula 2 compounds) is raw material, reaction obtains 5-(α-cyclopropyl carbonyl-2-luorobenzyl)-2-oxygen-2,4,5 under alkaline condition, 6,7,7a-six hydrogen thieno-s [3,2-c] pyridine (formula 3 compounds).
But the defective of aforesaid method is that formula (1) compound is as the important source material of preparation prasugrel, and not cheap industrial goods can be bought on market at present.And in disclosed prior art U.S. Pat 470510, its synthetic method is by 4,5,6,7-tetramethylene sulfide also [3,2-c] pyridine at low temperatures with the reaction of n-Butyl Lithium, tributyl borate, obtain 5-trityl-2-oxygen-2,4,5,6,7 α-six hydrogen thieno-[3,2-c] pyridine, last and formic acid reaction obtains target product.Its reaction conditions is very harsh, needs-40 ℃ low temperature, and n-Butyl Lithium is inflammable and explosive simultaneously, can bring danger to scale operation.
The present inventor finds that by known compound 2-methoxyl group-5-(α-cyclopropyl carbonyl-2-luorobenzyl)-4,5,6,7-tetramethylene sulfide also [3,2-c] pyridine (its structural formula is as shown in the formula VIII) just can be prepared prasugrel very easily,
But existing preparation 2-methoxyl group-5-(α-cyclopropyl carbonyl-2-luorobenzyl)-4,5,6,7-tetramethylene sulfide also [3,2-c] method of pyridine is unsuitable for big suitability for industrialized production, it is to prepare by above-mentioned compound (3), and the preparation method of compound (3) also is the target product that obtains by compound (1) and compound (2) reaction.Therefore need work out a kind of economy, safety, be suitable for the big preparation 2-methoxyl group-5-(α-cyclopropyl carbonyl-2-luorobenzyl)-4,5,6 that produces, the 7-tetramethylene sulfide is the method for [3,2-c] pyridine also.
Summary of the invention
Purpose of the present invention just provides a kind of new 2-methoxyl group-5-(α-cyclopropyl carbonyl-2-luorobenzyl)-4,5,6,7-tetramethylene sulfide also [3,2-c] preparation method of pyridine, this method has overcome existing Synthetic 2-methoxyl group-5-(α-cyclopropyl carbonyl-2-luorobenzyl)-4,5,6,7-tetramethylene sulfide also [3,2-c] the above-mentioned defective of pyridine technology, be very suitable for that industry is big produces, and yield is than existing method height.
The present inventor is through a large amount of experiments, surprised discovery, can directly utilize existing compound, can prepare 2-methoxyl group-5-(α-cyclopropyl carbonyl-2-luorobenzyl)-4,5,6 by single step reaction, 7-tetramethylene sulfide also [3,2-c] pyridine, not only stable reaction, yield height, and reaction conditions gentleness.Its concrete technical scheme of taking is as follows:
2-methoxyl group-5-(α-cyclopropyl carbonyl-2-luorobenzyl)-4,5,6, the 7-tetramethylene sulfide is the preparation method of [3,2-c] pyridine also, and this method is: the compound VI and the compound VI I of following formula are carried out condensation reaction
Wherein R represents alkyl, and X represents Br or Cl.The alkyl of preferred 1～20 carbon atom of R, the alkyl of preferred especially 1～3 carbon atom.
Above-mentioned formula VI compound and formula VII compound react under alkaline condition and obtain formula VIII compound, and used alkali can be triethylamine, diisopropylethylamine, yellow soda ash, sodium bicarbonate, salt of wormwood or saleratus etc.In this condensation reaction, can also add catalyzer, as sodium iodide or potassiumiodide.
Preferable scheme is: formula VI compound is to prepare as follows
Step 1: formula I compound and formula II compound react under alkaline condition
Obtain the formula III compound,
Step 2: the halogenation of formula III compound obtains formula IV compound,
Step 3: formula IV compound and sodium alkoxide or potassium alcoholate react under the catalyzer condition and obtain formula V compound,
Step 4: formula V compound debenzylation promptly obtains target compound VI
Wherein X represents Br or Cl, and R represents alkyl, the alkyl of preferred 1～20 carbon atom, the alkyl of preferred especially 1～3 carbon atom.
Above-mentioned step 1, used solvent is well known by persons skilled in the art during reaction, comprises alcohol, ester class, methylene dichloride, tetrahydrofuran (THF), benzene, toluene, acetonitrile, DMF etc., preferred acetonitrile and DMF, more preferably DMF.Temperature of reaction is according to used solvent, and those skilled in the art can select best temperature range.Operable alkali comprises mineral alkali and organic bases, as yellow soda ash, salt of wormwood, sodium bicarbonate, sodium hydroxide, triethylamine, diisopropylethylamine etc., and preferred mineral alkali such as yellow soda ash, salt of wormwood etc.Can also add catalyzer such as sodium iodide, potassiumiodide etc. in addition.
Above-mentioned step 2, halogenating agent preferably uses hydrobromic acid solution and hydrogen peroxide during halogenating reaction, also can use bromine.
Above-mentioned step 3, used solvent is well known by persons skilled in the art during reaction, comprises methyl alcohol, tetrahydrofuran (THF), dioxane, toluene, methyl-sulphoxide, preferred tetrahydrofuran (THF) or dioxane most preferably are dioxane.Used catalyzer comprises the mixture of cuprous salt or cuprous salt and iodide during halogenating reaction, and cuprous salt comprises Red copper oxide, cuprous chloride, cuprous bromide or cuprous iodide, preferred cuprous bromide or cuprous iodide; Iodide comprise sodium iodide, potassiumiodide.Used sodium alkoxide or potassium alcoholate comprise sodium methylate, sodium ethylate, sodium propylate, benzylalcohol sodium, sodium tert-butoxide, potassium tert.-butoxide etc., are preferably sodium methylate or sodium ethylate.
Above-mentioned step 4, the formula V compound reacts with chloro-formic ester earlier, and reaction obtains formula (VI) compound under alkaline condition again.Chloro-formic ester comprises methyl-chloroformate, Vinyl chloroformate, phenyl chloroformate, chloroformic acid vinyl acetate, trichloroethyl chloroformate, chloroformic acid α-chloro-ethyl ester, chloroformic acid vinyl acetate, allyl chlorocarbonate etc., preferred phenyl chloroformate or chloroformic acid vinyl acetate.When reacting under alkaline condition, the pH preferred range is greater than 12.
The preparation method of the prasugrel that the present invention is new, wherein step 3 and four target compounds can be converted into corresponding salt if necessary, are preferably hydrochloride, vitriol, maleate etc.
Beneficial effect of the present invention: the present invention has found that a kind of brand-new synthetic route prepares 2-methoxyl group-5-(α-cyclopropyl carbonyl-2-luorobenzyl)-4,5,6,7-tetramethylene sulfide also [3,2-c] pyridine, only need single step reaction from existing compound to target compound, and the reaction conditions gentleness, do not need low temperature, do not relate to inflammable and explosive raw material, yield is outstanding, is a kind of cost-effective method, is suitable for large-scale industrial production.
Embodiment
Preferred embodiment with concrete operations with reference to the following examples.
Embodiment 1～2
5-benzyl-4,5,6,7-tetramethylene sulfide be the preparation of [3,2-c] pyridines (formula III) also:
With 4,5,6,7-tetramethylene sulfide also [3,2-c] pyridines (7.0g), salt of wormwood (7.2g) mixes with acetonitrile (50ml), adds Benzyl Chloride (6.1g), stirs after 0.5 hour and refluxes 3 hours.Cooling is filtered, and filtrate is concentrated into dried, add ethyl acetate (30ml) and water (50ml), separatory, water layer extracts with ethyl acetate (30ml * 2), merge organic layer, washing, drying, be concentrated into the dried title compound 5-benzyl-4 that obtains, 5,6,7-tetramethylene sulfide also [3,2-c] pyridine 8.3g, yield 90.8%.
4,5,6,7-tetramethylene sulfide also [3,2-c] pyridine (18.0g), salt of wormwood (18.6g), Benzyl Chloride (15.0g), sodium iodide (0.8g) stir in DMF (100ml) after 0.5 hour in 80 ℃ of reactions 3 hours, and cooling adds entry (150ml) and ethyl acetate (100ml), separatory, water layer extracts with ethyl acetate (50ml * 2).Merge organic layer, washing, drying is concentrated into dried title compound 23.2g, yield 98.7%.
Embodiment 3
2-bromo-5-benzyl-4,5,6, the 7-tetramethylene sulfide is the preparation of [3,2-c] pyridines (formula IV) also:
The compound (23.2g) that embodiment 2 is obtained is dissolved in acetic acid (100.0ml), 40% Hydrogen bromide (75.0ml), the methyl alcohol (100ml), and the ice-water bath cooling drips methyl alcohol (100ml) solution of 30% hydrogen peroxide (33.0ml), stirring at room 3 hours down.Drip hypo solution (150ml), dripping saturated sodium carbonate solution again is 9 to pH, and methylene dichloride (100ml * 3) extracts, and merges organic layer, washing, and drying is concentrated into dried light yellow solid 30.5g, yield 97.8%.
Embodiment 4～6
2-methoxyl group-5-benzyl-4,5,6,7-tetramethylene sulfide be the preparation of [3,2-c] pyridines (formula V) also:
Sodium (0.43g) is dissolved in methyl alcohol (20ml), adds 2-bromo-5-benzyl-4,5,6, the 7-tetramethylene sulfide is [3,2-c] pyridines (3.88g), cuprous bromide (0.17g) also, stirring and refluxing 12 hours.Cooling is filtered, and filtrate is concentrated into dried, adds ethyl acetate (30ml) and water (50ml), separatory, water layer extracts with ethyl acetate (30ml * 2), merges organic layer, washing, drying is concentrated into dried oily matter 3.3g, and post separates and obtains title compound 1.3g, yield 39.8%.
Sodium (5.6g) is dissolved in methyl alcohol (120ml), is concentrated into driedly, add tetrahydrofuran (THF) (100ml), 2-bromo-5-benzyl-4,5,6, the 7-tetramethylene sulfide is [3,2-c] pyridines (7.5g), cuprous bromide (0.34g) and sodium iodide (0.15g) also, stirring and refluxing 24 hours.Cooling, filter and wash with ethyl acetate, filtrate is concentrated into dried, adds ethyl acetate (150ml) and water (250ml), separatory, water layer extracts with ethyl acetate (50ml * 2), merges organic layer, and disodium ethylene diamine tetra-acetic acid solution (50ml), water (50ml * 2) are washed, dry, be concentrated into dried oily matter 5.7g, post separates and obtains title compound 3.8g, yield 60.2%.
Sodium (24.0g) is dissolved in methyl alcohol (350ml), is concentrated into driedly, add dioxane (300ml), 2-bromo-5-benzyl-4,5,6, the 7-tetramethylene sulfide is [3,2-c] pyridines (30.5g), cuprous bromide (1.5g) and sodium iodide (0.8g) also, stirring and refluxing 16 hours.Cooling, filter and use methanol wash, filtrate is concentrated into dried, add ethyl acetate (150ml) and water (250ml), separatory, water layer extracts with ethyl acetate (100ml * 2), merge organic layer, disodium ethylene diamine tetra-acetic acid solution (100ml * 2), salt solution (100ml * 3) are washed, and drying is concentrated into dried oily matter 29.3g.Add ethyl acetate (200ml), the ethanolic soln pH that drips hydrogenchloride is 1, and ice-water bath stirred 1 hour, filters and washes with ethyl acetate, dry light yellow solid 24.0g, yield 82.2%.
Embodiment 7
2-methoxyl group-4,5,6,7-tetramethylene sulfide be the preparation of [3,2-c] pyridine hydrochlorides (formula VI) also:
With 2-methoxyl group-5-benzyl-4,5,6,7-tetramethylene sulfide also [3,2-c] to regulate pH be 12 to pyridine hydrochloride (20.0g) hydro-oxidation sodium solution, extracts with ethyl acetate (150ml * 3), merges organic layer, water (100ml * 3) is washed, and drying is concentrated into dried oily matter.Add toluene (240ml), diisopropylethylamine (26.5ml) and phenyl chloroformate (20ml), 70 ℃ of stirring reactions 2 hours.Cooling adds saturated sodium bicarbonate solution (180ml), layering, and organic layer is used salt solution (120ml) washing again with saturated sodium bicarbonate (120ml * 2) washing.Organic layer is concentrated into dried, adds the inferior maple (120ml) of diformazan, sodium hydroxide (12g) and water (18ml), 70 ℃ of stirring reactions 12 hours.Cooling adds frozen water (350ml), and it is 9 that the hydro-oxidation sodium solution is regulated pH.Extract with methylene dichloride (150ml * 3), washing, drying is concentrated into dried oily matter 27.5g.(200ml) dissolving that adds diethyl ether, it is 3 that the diethyl ether solution that drips hydrogenchloride is regulated pH, ice-water bath stirred 1 hour, filtered and washed with ether, dry light yellow solid 11.2g, yield 80.3%.
Embodiment 8～9
2-methoxyl group-5-(α-cyclopropyl carbonyl-2-luorobenzyl)-4,5,6, the 7-tetramethylene sulfide is the preparation of [3,2-c] pyridine hydrochlorides (formula VIII) also:
With 2-methoxyl group-4,5,6, the 7-tetramethylene sulfide also [3,2-c] pyridine hydrochlorides (0.40g) hydro-oxidation sodium solution to regulate pH be 12, extract with methylene dichloride (10ml * 3), merge organic layer, water (10ml * 2) is washed, drying is concentrated into dried oily matter.Add formula (VII) compound (0.45g), salt of wormwood (0.32g) and acetonitrile (30ml), refluxed 3 hours, cooling is filtered and is washed with acetonitrile.Filtrate is concentrated into dried, adds water (30ml), extracts with ethyl acetate (20ml * 3), merges organic layer, washing, and drying is concentrated into dried oily matter 0.75g.(30ml) dissolving that adds diethyl ether, it is 3 that the diethyl ether solution that drips hydrogenchloride is regulated pH, ice-water bath stirred 1 hour, filtered and washed with ether, dry light yellow solid 0.65g, yield 87.5%.
With 2-methoxyl group-4,5,6, the 7-tetramethylene sulfide also [3,2-c] pyridine hydrochlorides (1.25g) hydro-oxidation sodium solution to regulate pH be 12, extract with methylene dichloride (15ml * 3), merge organic layer, water (10ml * 2) is washed, drying is concentrated into dried oily matter.Add formula (VII) compound (1.42g), salt of wormwood (1.01g), sodium iodide (0.1g) and acetonitrile (30ml), refluxed 3 hours, cooling is filtered and is washed with acetonitrile.Filtrate is concentrated into dried, adds water (50ml), extracts with ethyl acetate (30ml * 3), merges organic layer, washing, and drying is concentrated into dried oily matter 2.5g.(50ml) dissolving that adds diethyl ether, it is 3 that the diethyl ether solution that drips hydrogenchloride is regulated pH, ice-water bath stirred 1 hour, filtered and washed with ether, dry light yellow solid 2.15g, yield 92.6%.
Embodiment 10
5-(α-cyclopropyl carbonyl-2-luorobenzyl)-2-oxygen-2,4,5,6,7, the preparation of 7a-six hydrogen thieno-s [3,2-c] pyridine hydrochlorides (formula IX):
2-methoxyl group-5-(α-cyclopropyl carbonyl-2-luorobenzyl)-4,5,6,7-tetramethylene sulfide also [3,2-c] pyridine hydrochlorides (2.15g), 1M hydrochloric acid (20ml) reacted 3 hours in 80 ℃.Cooling, with the sodium carbonate solution neutralization, ethyl acetate (30ml * 3) is extracted, and merges organic layer, and water (10ml * 2) is washed, and drying is concentrated into dried.(50ml) dissolving that adds diethyl ether, it is 3 that the diethyl ether solution that drips hydrogenchloride is regulated pH, ice-water bath stirred 1 hour, filtered and washed with ether, dry light yellow solid 1.55g, yield 74.8%.
Embodiment 11
2-acetoxyl group-5-(α-cyclopropyl carbonyl-2-luorobenzyl)-4,5,6, the 7-tetramethylene sulfide is the preparation of [3,2-c] pyridine hydrochloride (being prasugrel) also:
5-(α-cyclopropyl carbonyl-2-luorobenzyl)-2-oxygen-2,4,5,6,7,7a-six hydrogen thieno-s [3,2-c] pyridine hydrochlorides (0.3g), adding sodium carbonate solution adjusting pH value is 7～8, extract with ethyl acetate (15ml * 3), merge organic layer, water (10ml * 2) is washed, drying, is concentrated into dried.Add N, dinethylformamide (2ml), acetic anhydride (1ml), the frozen water cooling adds 60% sodium hydrogen (0.1g), stirring at room 3 hours.Add ethyl acetate (40ml), salt solution (10ml * 3) is washed, and drying is concentrated into dried.(20ml) dissolving that adds diethyl ether, it is 3 that the diethyl ether solution that drips hydrogenchloride is regulated pH, ice-water bath stirred 1 hour, filtered and washed with ether, dry white solid 0.22g, yield 65.8%.
Claims (20)
1.2-methoxyl group-5-(α-cyclopropyl carbonyl-2-luorobenzyl)-4,5,6, the 7-tetramethylene sulfide is the preparation method of [3,2-c] pyridine also, and this method is: the compound VI and the compound VI I of following formula are carried out condensation reaction
Wherein R represents alkyl, and X represents Br or Cl.
2. 2-methoxyl group-5-as claimed in claim 1 (α-cyclopropyl carbonyl-2-luorobenzyl)-4,5,6, the 7-tetramethylene sulfide is the preparation method of [3,2-c] pyridine also, it is characterized in that: R is the alkyl of 1～20 carbon atom.
3. 2-methoxyl group-5-as claimed in claim 2 (α-cyclopropyl carbonyl-2-luorobenzyl)-4,5,6, the 7-tetramethylene sulfide is the preparation method of [3,2-c] pyridine also, it is characterized in that: R is the alkyl of 1～3 carbon atom.
4. as the described arbitrary 2-methoxyl group-5-of claim 1～3 (α-cyclopropyl carbonyl-2-luorobenzyl)-4,5,6, the 7-tetramethylene sulfide also [3,2-c] pyridine the preparation method, it is characterized in that: this reaction can also add catalyzer sodium iodide or potassiumiodide.
5. as the described arbitrary 2-methoxyl group-5-of claim 1～3 (α-cyclopropyl carbonyl-2-luorobenzyl)-4,5,6,7-tetramethylene sulfide also [3,2-c] pyridine the preparation method, it is characterized in that: this is reflected under the alkaline condition and carries out, and used alkali comprises triethylamine, diisopropylethylamine, yellow soda ash, sodium bicarbonate, salt of wormwood and saleratus.
6. as the described arbitrary 2-methoxyl group-5-of claim 1～3 (α-cyclopropyl carbonyl-2-luorobenzyl)-4,5,6, the 7-tetramethylene sulfide also [3,2-c] pyridine the preparation method, it is characterized in that: formula VI compound prepares as follows
Step 1: formula I compound and formula II compound react under alkaline condition
Obtain the formula III compound,
Step 2: the halogenation of formula III compound obtains formula IV compound,
Step 3: formula IV compound and sodium alkoxide or potassium alcoholate react under the catalyzer condition and obtain formula V compound,
Step 4: formula V compound debenzylation promptly obtains target compound VI
Wherein X represents Br or Cl, and R represents alkyl.
7. 2-methoxyl group-5-as claimed in claim 6 (α-cyclopropyl carbonyl-2-luorobenzyl)-4,5,6, the 7-tetramethylene sulfide is the preparation method of [3,2-c] pyridine also, it is characterized in that: step 1 can also add catalyzer such as sodium iodide or potassiumiodide.
8. 2-methoxyl group-5-as claimed in claim 6 (α-cyclopropyl carbonyl-2-luorobenzyl)-4,5,6, the 7-tetramethylene sulfide is the preparation method of [3,2-c] pyridine also, it is characterized in that: used solvent is acetonitrile or DMF during the step 1 reaction.
9. 2-methoxyl group-5-as claimed in claim 6 (α-cyclopropyl carbonyl-2-luorobenzyl)-4,5,6,7-tetramethylene sulfide also [3,2-c] preparation method of pyridine, it is characterized in that: the alkali that uses during the step 1 reaction comprises yellow soda ash, salt of wormwood, sodium bicarbonate, sodium hydroxide, triethylamine, diisopropylethylamine.
10. 2-methoxyl group-5-as claimed in claim 6 (α-cyclopropyl carbonyl-2-luorobenzyl)-4,5,6, the 7-tetramethylene sulfide is the preparation method of [3,2-c] pyridine also, it is characterized in that: halogenating agent is hydrobromic acid solution and hydrogen peroxide during the step 2 halogenating reaction.
11. 2-methoxyl group-5-as claimed in claim 6 (α-cyclopropyl carbonyl-2-luorobenzyl)-4,5,6, the 7-tetramethylene sulfide is the preparation method of [3,2-c] pyridine also, it is characterized in that: used solvent is tetrahydrofuran (THF) or dioxane during the step 3 reaction.
12. 2-methoxyl group-5-as claimed in claim 6 (α-cyclopropyl carbonyl-2-luorobenzyl)-4,5,6,7-tetramethylene sulfide also [3,2-c] preparation method of pyridine, it is characterized in that: used catalyzer comprises the mixture of cuprous salt or cuprous salt and iodide during the step 3 reaction.
13. 2-methoxyl group-5-as claimed in claim 12 (α-cyclopropyl carbonyl-2-luorobenzyl)-4,5,6,7-tetramethylene sulfide also [3,2-c] preparation method of pyridine, it is characterized in that: said cuprous salt comprises Red copper oxide, cuprous chloride, cuprous bromide or cuprous iodide; Iodide comprise sodium iodide, potassiumiodide.
14. 2-methoxyl group-5-as claimed in claim 13 (α-cyclopropyl carbonyl-2-luorobenzyl)-4,5,6, the 7-tetramethylene sulfide is the preparation method of [3,2-c] pyridine also, and it is characterized in that: said cuprous salt comprises cuprous bromide or cuprous iodide.
15. 2-methoxyl group-5-as claimed in claim 6 (α-cyclopropyl carbonyl-2-luorobenzyl)-4,5,6,7-tetramethylene sulfide also [3,2-c] preparation method of pyridine, it is characterized in that: said sodium alkoxide of step 3 or potassium alcoholate comprise sodium methylate, sodium ethylate, sodium propylate, benzylalcohol sodium, sodium tert-butoxide, potassium tert.-butoxide.
16. 2-methoxyl group-5-as claimed in claim 15 (α-cyclopropyl carbonyl-2-luorobenzyl)-4,5,6, the 7-tetramethylene sulfide is the preparation method of [3,2-c] pyridine also, it is characterized in that: said sodium alkoxide of step 3 or potassium alcoholate are sodium methylate or sodium ethylate.
17. 2-methoxyl group-5-as claimed in claim 6 (α-cyclopropyl carbonyl-2-luorobenzyl)-4,5,6,7-tetramethylene sulfide also [3,2-c] preparation method of pyridine, it is characterized in that: step 4, the formula V compound reacts with chloro-formic ester earlier, and reaction obtains formula (VI) compound under alkaline condition again.
18. 2-methoxyl group-5-as claimed in claim 17 (α-cyclopropyl carbonyl-2-luorobenzyl)-4,5,6,7-tetramethylene sulfide also [3,2-c] preparation method of pyridine, it is characterized in that: said chloro-formic ester comprises methyl-chloroformate, Vinyl chloroformate, phenyl chloroformate, chloroformic acid vinyl acetate, trichloroethyl chloroformate, chloroformic acid α-chloro-ethyl ester, chloroformic acid vinyl acetate, allyl chlorocarbonate.
19. 2-methoxyl group-5-as claimed in claim 18 (α-cyclopropyl carbonyl-2-luorobenzyl)-4,5,6, the 7-tetramethylene sulfide is the preparation method of [3,2-c] pyridine also, it is characterized in that: said chloro-formic ester is phenyl chloroformate or chloroformic acid vinyl acetate.
20. 2-methoxyl group-5-as claimed in claim 6 (α-cyclopropyl carbonyl-2-luorobenzyl)-4,5,6,7-tetramethylene sulfide also [3,2-c] preparation method of pyridine, it is characterized in that: step 3 and step 4 target compound can be converted into corresponding salt if necessary.
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| WO2011077173A1 (en) | 2009-12-21 | 2011-06-30 | Egis Gyógyszergyár Nyilánosan Működő Részvénytársaság | Improved process for preparing a pharmaceutical compound |
| WO2011110219A1 (en) | 2010-03-09 | 2011-09-15 | Synthon Bv | A process for making prasugrel |
| CN102199163A (en) * | 2011-04-01 | 2011-09-28 | 中国药科大学 | 2-hydroxy tetrahydrothiophene derivative, preparation method thereof and application thereof in pharmacy |
| CN102212070A (en) * | 2010-04-08 | 2011-10-12 | 上海医药工业研究院 | Preparation method for 2-acetoxyl-5-(alpha-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine |
| WO2012052788A1 (en) | 2010-10-22 | 2012-04-26 | Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság | Method for preparing pharmaceutically active ingredient and intermediates thereof |
| CN103694251A (en) * | 2014-01-06 | 2014-04-02 | 南京简成医药科技有限公司 | Novel preparation process of prasugrel hydrochloride |
| CN105669699A (en) * | 2016-03-07 | 2016-06-15 | 山东罗欣药业集团股份有限公司 | Preparation method of prasugrel hydrochloride |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI101150B (en) * | 1991-09-09 | 1998-04-30 | Sankyo Co | Process for the preparation of tetrahydrothione nopyridine derivatives useful as a drug |
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| WO2011077173A1 (en) | 2009-12-21 | 2011-06-30 | Egis Gyógyszergyár Nyilánosan Működő Részvénytársaság | Improved process for preparing a pharmaceutical compound |
| US9169265B2 (en) | 2009-12-21 | 2015-10-27 | Egis Gyogyszergyar Nyilvanosan Mukodo Reszvenytarsasag | Process for preparing pharmaceutical compounds and intermediate compounds |
| CN102869668A (en) * | 2010-03-09 | 2013-01-09 | 斯索恩有限公司 | Process for making prasugrel |
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