CN101249173B - Traditional Chinese medicine preparation for curing gout and method of preparing the same - Google Patents
Traditional Chinese medicine preparation for curing gout and method of preparing the same Download PDFInfo
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- CN101249173B CN101249173B CN2008103008457A CN200810300845A CN101249173B CN 101249173 B CN101249173 B CN 101249173B CN 2008103008457 A CN2008103008457 A CN 2008103008457A CN 200810300845 A CN200810300845 A CN 200810300845A CN 101249173 B CN101249173 B CN 101249173B
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating gout and a preparation method thereof. The traditional Chinese medicine preparation is mainly made from the raw ingredient medicines by weight parts as follows: radix rehmanniae, pawpaw, Radix Aucklandiae, angelica dahurica, Wu Chia Pee, achyranthes and radix aconiti feri are respectively 100 to 250 parts; panax notoginseng and fennel are respectively 10 to 40 parts; camphor is 25 to 75 parts; borneol is 10 to 30 parts; mush/muskone is 0.1 to 0.5 parts. Compared with the prior art, the traditional Chinese medicine preparation has specific antiphlogistic effect to non-steroid inflammation, and has the functions of clearing heat as well as removing dampness, activating blood circulation and dredging collaterals, and promoting vascular regeneration; by adopting the modern extraction technology, the invention fully extracts the active ingredients in the traditional Chinese medicine to make a external preparation which can be applied on affected parts directly; through percutaneous absorption, no liver first pass effect occurs, the traditional Chinese medicine preparation has no damage to the liver, stomach, kidney, etc., without toxic and side effects, the curative effect is good and thorough, and the relapse is avoided.
Description
(1) technical field:
The present invention relates to a kind of Chinese medicine preparation for the treatment of gout and preparation method thereof, belong to technical field of traditional Chinese medicine pharmacy.
(2) background technology:
The treatment gout mainly adopts medicines such as oral " colchicine ", " allopurinol ", " narcaricin " both at home and abroad at present, though these medicine effects are rapider, analgesic effect is fast, has the comparison serious adverse, especially gastrointestinal tract is had than macrolesion.And the toxic and side effects of Chinese medicine is relatively very little, and therefore the development of Chinese medicine is in recent years paid close attention to by people day by day.The principle of Chinese traditional treatment gout is to be method with clearing away heat-damp and promoting diuresis, promoting blood circulation to remove obstruction in the collateral, and acute stage is dialectical to be retention of damp-heat in the interior, and treatment is based on clearing away heat-damp and promoting diuresis; Catabasis is dialectical to be obstruction of collaterals by blood stasis, and treatment is based on promoting blood circulation to remove obstruction in the collateral.At present also there is not effect to treat the external preparation of gout preferably on the market.
(3) summary of the invention:
The present invention overcomes the Western medicine side effect greatly and the few shortcoming of eutherapeutic external preparation, and Chinese medicine preparation that a kind of curative effect treats gout preferably and preparation method thereof is provided.
Technical scheme of the present invention: the Chinese medicine preparation of treatment gout, mainly be to make: respectively 100～250 parts of the Radix Rehmanniae, Fructus Chaenomelis, the Radix Aucklandiae, the Radix Angelicae Dahuricae, Cortex Acanthopancis, Radix Achyranthis Bidentatae, Radix Aconiti Kusnezoffii with following bulk drugs, each 10～40 parts in Radix Notoginseng, Fructus Foeniculi, 25～75 parts of Camphoras, 0.1～0.5 part in 10～30 parts of Borneolum Syntheticums and Moschus (or muscone).
Preferred each crude drug consumption is: respectively 150 parts of the Radix Rehmanniae, Fructus Chaenomelis, the Radix Aucklandiae, the Radix Angelicae Dahuricae, Cortex Acanthopancis, Radix Achyranthis Bidentatae, Radix Aconiti Kusnezoffii, each 20 parts in Radix Notoginseng, Fructus Foeniculi, 50 parts of Camphoras, 0.1 part in 20 parts of Borneolum Syntheticums and Moschus (or muscone).
In order to reach better therapeutic, can also add Pseudobulbus Cremastrae Seu Pleiones 100～250 weight portions in the crude drug of Chinese medicine preparation of the present invention.
Preferred each crude drug consumption is after adding Pseudobulbus Cremastrae Seu Pleiones: respectively 150 parts of the Radix Rehmanniae, Fructus Chaenomelis, the Radix Aucklandiae, the Radix Angelicae Dahuricae, Cortex Acanthopancis, Radix Achyranthis Bidentatae, Radix Aconiti Kusnezoffii, Pseudobulbus Cremastrae Seu Pleioness, each 20 parts in Radix Notoginseng, Fructus Foeniculi, 50 parts of Camphoras, 0.1 part in 20 parts of Borneolum Syntheticums and Moschus (or muscone).
Described Chinese medicine preparation is tincture, gel or plaster.
The preparation method of the Chinese medicine preparation of treatment gout is: get the Radix Rehmanniae, Fructus Chaenomelis, the Radix Aucklandiae, the Radix Angelicae Dahuricae, Cortex Acanthopancis, Radix Achyranthis Bidentatae, Radix Aconiti Kusnezoffii, each 100～250 weight portion of Pseudobulbus Cremastrae Seu Pleiones, Radix Notoginseng, each 10～40 weight portion of Fructus Foeniculi, pulverize, add the water mixing, quick freezing, taking-up is heated to boils, and repeats quick freezing and be heated to boil three times; Cold after-filtration is collected filtrate, adds the alcoholic solution stirring and leaching in the filtering residue, filter, three times repeatedly, merging filtrate, camphorate 25～75 weight portions, Borneolum Syntheticum 10～30 weight portions, Moschus (or muscone) 0.1～0.5 weight portion stir, and make various preparation.Repeat quick freezing in the preparation process and be heated to that to boil be to utilize the principle of expanding with heat and contract with cold, by rapid cooling, heating up makes the cell wall rupture of raw medicinal material, fully discharging the effective ingredient in the cell wall at short notice, thus the raising extraction efficiency.
Preparation method is more specifically: get the Radix Rehmanniae, Fructus Chaenomelis, the Radix Aucklandiae, the Radix Angelicae Dahuricae, Cortex Acanthopancis, Radix Achyranthis Bidentatae, Radix Aconiti Kusnezoffii, each 150 weight portion of Pseudobulbus Cremastrae Seu Pleiones, Radix Notoginseng, each 20 weight portion of Fructus Foeniculi, pulverize, add the water mixing by 0.8～1.2ml (water)/g (raw medicinal material), quick freezing below 0 ℃ (temperature is low more, and freezing speed is fast more, and effect is good more), taking-up is heated to boils, and repeats quick freezing and be heated to boil three times; Cold after-filtration, collect filtrate, press 1ml (ethanol)/0.75～0.80g (filtering residue) and in filtering residue, added 50% alcoholic solution stirring and leaching 24～48 hours, filter, three times repeatedly, merging filtrate, 50 weight portions that camphorate, Borneolum Syntheticum 20 weight portions, Moschus (or muscone) 0.1 weight portion, stir, make tincture or further make gel, plaster.
The Chinese medicine preparation that the present invention treats gout also can adopt conventional leach extraction method to be prepared, promptly get the Radix Rehmanniae, Fructus Chaenomelis, the Radix Aucklandiae, the Radix Angelicae Dahuricae, Cortex Acanthopancis, Radix Achyranthis Bidentatae, Radix Aconiti Kusnezoffii, each 100～250 weight portion of Pseudobulbus Cremastrae Seu Pleiones, Radix Notoginseng, each 10～40 weight portion of Fructus Foeniculi, pulverize, add alcoholic solution room temperature lixiviate 20～40 days, filter, collect filtrate, camphorate 25～75 weight portions, Borneolum Syntheticum 10～30 weight portions, Moschus (or muscone) 0.1～0.5 weight portion stir, and make various preparation.This kind preparation method and preceding method can reach same effect, and just extraction time is longer.
Conventional more specifically lixiviate preparation method is: get the Radix Rehmanniae, Fructus Chaenomelis, the Radix Aucklandiae, the Radix Angelicae Dahuricae, Cortex Acanthopancis, Radix Achyranthis Bidentatae, Radix Aconiti Kusnezoffii, each 150 weight portion of Pseudobulbus Cremastrae Seu Pleiones, Radix Notoginseng, each 20 weight portion of Fructus Foeniculi, pulverize, add 50% alcoholic solution room temperature lixiviate 25～35 days by 3～4ml (ethanol)/g (raw medicinal material), filter, collect filtrate, 50 weight portions that camphorate, Borneolum Syntheticum 20 weight portions, Moschus (or muscone) 0.1 weight portion, stir, make tincture or further make gel, plaster.
Described gel is made like this: get the tincture medicinal liquid, slowly add an amount of thickening agent under stirring, and adding aqueous slkali, to transfer pH value be 5～7, is stirred to no naked eyes visible particle that placement is spent the night, promptly.Described plaster is made like this: get the tincture medicinal liquid, vacuum concentration (vacuum is greater than 400mmHg) is to 0.1 times of volume, and it is standby to be prepared into fluid extract; Weight ratio by fluid extract and rubber is 1～3: 10 take by weighing rubber, weight ratio by gasoline and rubber is 1: 0.5～2 adding gasoline soaked overnight swellings, petrol such as adding again stirs, add standby fluid extract, stir, the rubber-emplastrum that stirs is uniformly coated on the cotton, oven dry, cutting, promptly.
In the prescription of the present invention, Radix Aconiti Kusnezoffii is hot in nature, acrid in the mouth, hardship, and expelling wind and removing dampness, antalgic is used for that anemofrigid-damp arthralgia, arthralgia, trusted subordinate's cold type of pain, colic of cold type are had a pain, narcotic analgesic, is principal agent (monarch drug); The Pseudobulbus Cremastrae Seu Pleiones heat-clearing and toxic substances removing, the eliminating carbuncle eliminating stagnation, with Radix Aconiti Kusnezoffii be principal agent (monarch drug) altogether.Ministerial drug is Radix Notoginseng, Cortex Acanthopancis, Radix Achyranthis Bidentatae, the Radix Aucklandiae and the Radix Angelicae Dahuricae, wherein Radix Notoginseng hemostasis, dissipating blood stasis, detumescence, analgesic therapy; The Cortex Acanthopancis wind-damp dispelling, strengthening bone and muscle, blood circulation and promoting silt is used for anemofrigid-damp arthralgia, and the muscles and bones contraction is anxious, lumbago, sexual impotence, flaccidity of the lower limbs, children's's walking retardation in children, edema, beriberi, skin ulcer cellulitis toxic swelling, traumatic injury impairment caused by overstrain; Radix Achyranthis Bidentatae dissipating blood stasis blood, subduing inflammation; Radix Aucklandiae promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion, be used for heavy behind breast gastral cavity distending pain, the dysentery, food stagnation does not disappear, anorexia; The Radix Angelicae Dahuricae has antipyretic effect.Adjuvant drug is Fructus Foeniculi, the Radix Rehmanniae, Moschus and Fructus Chaenomelis, Fructus Foeniculi warming YANG wherein, and cold expelling is regulated the flow of vital energy, and controls the invasion by pathogenic cold vomiting, colic of cold type stomachache, lumbago due to renal deficiency is done, beriberi caused by pathogenic damp; Radix Rehmanniae clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting cures mainly YIN damaged by pathogenic heat, the crimson tongue excessive thirst, interior-heat caused by deficiency of YIN, night fever abating at dawn, the hectic fever due to YIN-deficiency consumptive fever, interior-heat is quenched one's thirst, hematemesis and epistaxis, maculopapulae due to toxic heat; Moschus is had one's ideas straightened out, ward off dirty, collateral dredging, dissipating blood stasis is controlled apoplexy, syncope due to accumulation of phlegm, infantile convulsion, attacked by pestiferous factors unhappiness, trusted subordinate's sudden pain mass in the abdomen hypochondriac lump, traumatic injury, (because natural Moschus's resource scarcity, country has carried out restriction to Moschus and has used swollen ulcer drug, and the function of the muscone of synthetic and Moschus, curative effect are approximate, and therefore the Moschus in the prescription can adopt the equivalent muscone to replace); The Fructus Chaenomelis suppressing the hyperactive liver and easing the stomach, the Shujin that dries is controlled the convulsion of vomiting and diarrhoea, arthralgia chiefly caused by damp pathogen, beriberi, edema, dysentery.Borneolum Syntheticum and Camphora are messenger drug, and Borneolum Syntheticum leads to all keys, the stagnated fire of loosing, and removing nebula makes eye bright, reducing swelling and alleviating pain; Camphora is sensible, parasite killing, and pain relieving is warded off dirtyly, and external can ease pain, antipruritic and assist to diminish inflammation, and is used for myalgia, neuralgia, chilblain, skin pruritus.Above-mentioned monarch, minister, help, make the mutual compatibility of totally ten multi-flavor medicines, Synergistic, play the effect of clearing away heat-damp and promoting diuresis, promoting blood circulation to remove obstruction in the collateral, anti-inflammatory analgetic altogether, be used for diseases such as local red, swollen, hot, pain such as neck that gouty arthritis and nonsteroidal inflammation cause, shoulder, waist, lower limb.
During no Pseudobulbus Cremastrae Seu Pleiones, be mainly used in the treatment of acute stage gout in the present invention prescription, relief of symptoms fast, anti-inflammatory analgetic; When adding Pseudobulbus Cremastrae Seu Pleiones in the prescription, be mainly used in the treatment of catabasis gout, can eradicate the cause of disease, effectively prevent the recurrence of gout class diseases.
Compared with prior art, Chinese medicine preparation of the present invention has the specificity antiinflammation to the nonsteroidal inflammation, and has clearing away heat-damp and promoting diuresis, promoting blood circulation to remove obstruction in the collateral and short revascularization function; The present invention adopts modern extraction technique to make external preparation behind the pharmaceutically active ingredient in fully extracting, and can be directly used in the affected part, passes through Transdermal absorption, no liver first-pass effect to the not infringement of internal organs such as liver, stomach, kidney, has no side effect, and therapeutic effect is good, thorough, can prevent recurrence.
(4) specific embodiment:
Embodiments of the invention 1: get the Radix Rehmanniae, Fructus Chaenomelis, the Radix Aucklandiae, the Radix Angelicae Dahuricae, Cortex Acanthopancis, Radix Achyranthis Bidentatae, each 150 gram of Radix Aconiti Kusnezoffii (perhaps getting the Radix Rehmanniae, Fructus Chaenomelis, the Radix Aucklandiae, the Radix Angelicae Dahuricae, Cortex Acanthopancis, Radix Achyranthis Bidentatae, Radix Aconiti Kusnezoffii, each 150 gram of Pseudobulbus Cremastrae Seu Pleiones), Radix Notoginseng, each 20 gram of Fructus Foeniculi, pulverize, add 1200ml water, mixing, quick freezing under-10 ℃ of environment is taken out to be heated to and is boiled, and repeats quick freezing and be heated to boil three times; Cold after-filtration is collected filtrate, adds 1000ml 50% ethanol stirring and leaching 36 hours in the filtering residue, filters; Three times repeatedly, merging filtrate, 50 grams that camphorate, Borneolum Syntheticum 20 grams, Moschus 0.1 gram stirred 1 hour, and sealing is preserved, and promptly gets the tincture for the treatment of gout.Dipping in taking liquid during use directly is coated with and puts on the skin in the affected part.
Experimental example 1:
1, the literary composition certain, the man, 52 years old, patient was addicted to drink and the preference for fat and sweet food savoury, gout medical history 14 years is obeyed allopurinol, colchicine controlling symptoms usually.Since nearly 1 year, symptom obviously increases the weight of, and outbreak is frequent, almost acute attack in every month, and right sufficient halluces metatarsophalangeal joints severe pain during morbidity, the persistent period surpasses 7 days, takes the colchicine DeGrain.Use in November, 2007 embodiment 1 prepared tincture soak to spend the night, swelling and ache obviously alleviates, and uses two days later transference cure continuously.
2, Liao, the woman, 34 years old this year, gout has had 3 years, develops into every two weeks criminal once, and badly influences work and life in 2007, use embodiment 1 prepared tincture soak when show effect in November, 2007, use transference cure two days later, used continuously for three weeks again, yet there are no recurrence in four months so far.
Embodiments of the invention 2: get the Radix Rehmanniae, Fructus Chaenomelis, the Radix Aucklandiae, the Radix Angelicae Dahuricae, Cortex Acanthopancis, Radix Achyranthis Bidentatae, each 100 gram of Radix Aconiti Kusnezoffii (perhaps getting the Radix Rehmanniae, Fructus Chaenomelis, the Radix Aucklandiae, the Radix Angelicae Dahuricae, Cortex Acanthopancis, Radix Achyranthis Bidentatae, Radix Aconiti Kusnezoffii, each 100 gram of Pseudobulbus Cremastrae Seu Pleiones), Radix Notoginseng, each 40 gram of Fructus Foeniculi, pulverize, add 850ml water, mixing, quick freezing under-10～-20 ℃ of environment is taken out to be heated to and is boiled, and repeats quick freezing and be heated to boil three times; Cold after-filtration is collected filtrate, adds 800ml 50% ethanol stirring and leaching 30 hours in the filtering residue, filters; Three times repeatedly, merging filtrate, 25 grams that camphorate, Borneolum Syntheticum 30 grams, muscone 0.1 gram stirred 50 minutes, and sealing is preserved, and promptly gets the tincture for the treatment of gout.Dipping in taking liquid during use directly is coated with and puts on the skin in the affected part.
Experimental example 2:
1, cover certain, the woman, 37 years old, in July, 2007, gout was shown effect for the first time, the big toe swollen joint is painful, continues 2 wheat harvesting periods, brings into use in October, 2007 embodiment 2 prepared tincture soaks to spend the night, use three times after, transference cure swells and ache.
2, Lin, the man 60 years old, falls ill since in November, 2007, the people becomes thin, durante dolors 1 month, and both sides, ankle joint are little swollen, toe, sole kermesinus, joint obviously is out of shape, and whole body pain is unbearable, and can't fall asleep evening, eats the analgesic and treats all do not have effect because of sheet.In December, 2007 uses embodiment 2 prepared tincture soaks, uses transference cure after three days.
Embodiments of the invention 3: get the Radix Rehmanniae, Fructus Chaenomelis, the Radix Aucklandiae, the Radix Angelicae Dahuricae, Cortex Acanthopancis, Radix Achyranthis Bidentatae, each 250 gram of Radix Aconiti Kusnezoffii (perhaps getting the Radix Rehmanniae, Fructus Chaenomelis, the Radix Aucklandiae, the Radix Angelicae Dahuricae, Cortex Acanthopancis, Radix Achyranthis Bidentatae, Radix Aconiti Kusnezoffii, each 250 gram of Pseudobulbus Cremastrae Seu Pleiones), Radix Notoginseng, each 10 gram of Fructus Foeniculi, pulverize, add 1900ml water, mixing, quick freezing under 0～-10 ℃ of degree environment is taken out to be heated to and is boiled, and repeats quick freezing and be heated to boil three times; Cold after-filtration is collected filtrate, adds 1600ml 50% alcoholic solution stirring and leaching 24 hours in the filtering residue, filters; Three times repeatedly, merging filtrate, 75 grams that camphorate, Borneolum Syntheticum 10 grams, Moschus 0.5 gram stirred 80 minutes; Taking liquid 500ml slowly adds 5g Acritamer 940 (making thickening agent) under stirring, and adding 10% sodium hydroxide solution, to transfer pH value be 5～7, is stirred to no naked eyes visible particle, and placement is spent the night, and promptly gets the gel for the treatment of gout.During use medicinal liquid being coated on the affected part gets final product.
Experimental example 3:
1, the patient revives certain, man, 37 years old, gout medical history 5 years.Acute gout arthritis was shown effect 6 times repeatedly in nearly 1 year.Based on ankle joint, the joint redness, Pi Wen increases, and can not touch.Be coated with outward with embodiment 3 prepared gels in November, 2007 and spend the night, swelling in second day promptly disappears.
2, Zeng, 40 years old, the woman, the strain acute gout arthritis of bringing out began outbreak at the beginning of 2007 10 months, and sorrowful and instep congestion and swelling pain in the ankle, uric acid level 635, two months be pain repeatedly.Take colchicine, ibuprofen and all do not have positive effect.In December, 2007 uses embodiment 3 prepared gel, transference cures two days later.
Embodiments of the invention 4: get the Radix Rehmanniae 100 grams, Fructus Chaenomelis 250 grams, the Radix Aucklandiae 100 grams, the Radix Angelicae Dahuricae 250 grams, Cortex Acanthopancis 100 grams, Radix Achyranthis Bidentatae 250 grams, Radix Aconiti Kusnezoffii 100 grams (perhaps getting the Radix Rehmanniae 100 grams, Fructus Chaenomelis 250 grams, the Radix Aucklandiae 100 grams, the Radix Angelicae Dahuricae 250 grams, Cortex Acanthopancis 100 grams, Radix Achyranthis Bidentatae 250 grams, Radix Aconiti Kusnezoffii 100 grams, Pseudobulbus Cremastrae Seu Pleiones 250 grams), Radix Notoginseng 10 grams, Fructus Foeniculi 40 grams, pulverize, add 1400ml water, mixing, quick freezing under-20～-30 ℃ of degree environment, taking-up is heated to boils, and repeats quick freezing and be heated to boil three times; Cold after-filtration is collected filtrate, adds 1100ml 50% alcoholic solution stirring and leaching 48 hours in the filtering residue, filters; Three times repeatedly, merging filtrate, 25 grams that camphorate, Borneolum Syntheticum 10 grams, muscone 0.3 gram stir; Taking liquid 500ml, vacuum concentration (vacuum is greater than 400mmHg) is standby to 50ml; Get 200g rubber,, add 200ml gasoline again and stir half an hour, add standby 50ml fluid extract, stirred one hour, the rubber-emplastrum that stirs is uniformly coated on the cotton with 200ml gasoline soaked overnight swelling, oven dry, cutting promptly gets the plaster for the treatment of gout.During use ointment being affixed on the affected part gets final product.
Experimental example 4: Zhao, the man, 49 years old, the gout medical history of outbreak is repeatedly arranged, after the gout outbreak, swelling of the feet gets terribly.Blood uric acid was reduced to normal range through one month treatment (mainly being oral drugs and transfusion) in 2007, but also detumescence fully of foot, and every evening is just severely painful.Because swelling of the feet is handicapped, badly influences work and daily life.Every day paste 8 hour three day after transference cure with embodiment 4 prepared plaster in November, 2007.
Embodiments of the invention 5: get the Radix Rehmanniae 250 grams, Fructus Chaenomelis 100 grams, the Radix Aucklandiae 250 grams, the Radix Angelicae Dahuricae 100 grams, Cortex Acanthopancis 250 grams, Radix Achyranthis Bidentatae 100 grams, Radix Aconiti Kusnezoffii 250 grams (perhaps getting the Radix Rehmanniae 250 grams, Fructus Chaenomelis 100 grams, the Radix Aucklandiae 250 grams, the Radix Angelicae Dahuricae 100 grams, Cortex Acanthopancis 250 grams, Radix Achyranthis Bidentatae 100 grams, Radix Aconiti Kusnezoffii 250 grams, Pseudobulbus Cremastrae Seu Pleiones 100 grams), Radix Notoginseng 40 grams, Fructus Foeniculi 10 grams, pulverize, add 1400ml water, mixing, quick freezing under-30～-40 ℃ of degree environment, taking-up is heated to boils, and repeats quick freezing and be heated to boil three times; Cold after-filtration is collected filtrate, adds 1100ml 50% alcoholic solution stirring and leaching 40 hours in the filtering residue, filters; Three times repeatedly, merging filtrate, 75 grams that camphorate, Borneolum Syntheticum 30 grams, Moschus 0.5 gram stir, and sealing is preserved, and promptly gets the tincture for the treatment of gout.
Test example 5: Liu, the man, painful existing 7,8 times more than of foot, left foot ankle inboard is with swelling of the feet, and former gout was just recovered in several days, continued the whole month commentariess on classics of not getting better in November, 2007, December embodiment 5 prepared tincture soak, transference cures two days later.
Embodiments of the invention 6: get the Radix Rehmanniae, Fructus Chaenomelis, the Radix Aucklandiae, the Radix Angelicae Dahuricae, Cortex Acanthopancis, Radix Achyranthis Bidentatae, each 150 gram of Radix Aconiti Kusnezoffii (perhaps getting the Radix Rehmanniae, Fructus Chaenomelis, the Radix Aucklandiae, the Radix Angelicae Dahuricae, Cortex Acanthopancis, Radix Achyranthis Bidentatae, Radix Aconiti Kusnezoffii, each 150 gram of Pseudobulbus Cremastrae Seu Pleiones), Radix Notoginseng, each 20 gram of Fructus Foeniculi, pulverize, add 4000ml 50% alcoholic solution room temperature lixiviate 1 month, filter, collect filtrate, 50 grams, Borneolum Syntheticum 20 grams, muscone 0.1 gram camphorate, stirred 1 hour, sealing is preserved, and promptly gets the tincture for the treatment of gout.Get tincture medicinal liquid 500ml, slowly add the 5g sodium carboxymethyl cellulose under stirring, be stirred to no naked eyes visible particle, placement is spent the night, and promptly gets the gel for the treatment of gout.Get tincture medicinal liquid 500ml, vacuum concentration is standby to the 50ml fluid extract; Get 250g rubber,, add 340ml gasoline again and stir, add standby 50ml fluid extract, stir, the rubber-emplastrum that stirs is uniformly coated on the cotton with 340ml gasoline soaked overnight swelling, oven dry, cutting promptly gets the plaster for the treatment of gout.
Test example 6: Huang, man, 30 years old, be in hospital because of fever, mistaken diagnosis is a tuberculous meningitis, blood uric acid 320 before the medication, after using month antituberculosis drugs, gout takes place, blood uric acid 580, after shown effect 5 times, after the colchicine treatment, recur in November, 2007 once more, uses embodiment 6 prepared plaster instead, pasted every day 8 hours, two days later transference cure.
Claims (2)
1. treat the Chinese medicine for outer use of gout, it is characterized in that: it mainly is to make with following bulk drugs: respectively 100～250 parts of the Radix Rehmanniae, Fructus Chaenomelis, the Radix Aucklandiae, the Radix Angelicae Dahuricae, Cortex Acanthopancis, Radix Achyranthis Bidentatae, Radix Aconiti Kusnezoffii, each 10～40 parts in Radix Notoginseng, Fructus Foeniculi, 25～75 parts of Camphoras, 0.1～0.5 part of 10～30 parts of Borneolum Syntheticums and Moschus/muscone.
2. according to the Chinese medicine for outer use of the described treatment gout of claim 1, it is characterized in that: the consumption of each crude drug is: respectively 150 parts of the Radix Rehmanniae, Fructus Chaenomelis, the Radix Aucklandiae, the Radix Angelicae Dahuricae, Cortex Acanthopancis, Radix Achyranthis Bidentatae, Radix Aconiti Kusnezoffii, each 20 parts in Radix Notoginseng, Fructus Foeniculi, 50 parts of Camphoras, 0.1 part of 20 parts of Borneolum Syntheticums and Moschus/muscone.
3. according to the Chinese medicine for outer use of the described treatment gout of claim 1, it is characterized in that: crude drug also has 100～250 parts of Pseudobulbus Cremastrae Seu Pleioness.
4. according to the Chinese medicine for outer use of the described treatment gout of claim 3, it is characterized in that: the consumption of each crude drug is: respectively 150 parts of the Radix Rehmanniae, Fructus Chaenomelis, the Radix Aucklandiae, the Radix Angelicae Dahuricae, Cortex Acanthopancis, Radix Achyranthis Bidentatae, Radix Aconiti Kusnezoffii, Pseudobulbus Cremastrae Seu Pleioness, each 20 parts in Radix Notoginseng, Fructus Foeniculi, 50 parts of Camphoras, 0.1 part of 20 parts of Borneolum Syntheticums and Moschus/muscone.
5. according to the Chinese medicine for outer use of each described treatment gout among the claim 1-4, it is characterized in that: described Chinese medicine for outer use is tincture, gel or plaster.
6. treat the preparation method of the Chinese medicine for outer use of gout, it is characterized in that: get the Radix Rehmanniae, Fructus Chaenomelis, the Radix Aucklandiae, the Radix Angelicae Dahuricae, Cortex Acanthopancis, Radix Achyranthis Bidentatae, Radix Aconiti Kusnezoffii, each 100～250 weight portion of Pseudobulbus Cremastrae Seu Pleiones, Radix Notoginseng, each 10～40 weight portion of Fructus Foeniculi, pulverize, add the water mixing, quick freezing is taken out to be heated to and is boiled, and repeats quick freezing and be heated to boil three times; Cold after-filtration is collected filtrate, adds the alcoholic solution stirring and leaching in the filtering residue, filter, three times repeatedly, merging filtrate, camphorate 25～75 weight portions, Borneolum Syntheticum 10～30 weight portions, Moschus/muscone 0.1～0.5 weight portion stir, and make various external preparation.
7. according to the preparation method of the Chinese medicine for outer use of the described treatment gout of claim 6, it is characterized in that: get the Radix Rehmanniae, Fructus Chaenomelis, the Radix Aucklandiae, the Radix Angelicae Dahuricae, Cortex Acanthopancis, Radix Achyranthis Bidentatae, Radix Aconiti Kusnezoffii, each 150 weight portion of Pseudobulbus Cremastrae Seu Pleiones, Radix Notoginseng, each 20 weight portion of Fructus Foeniculi, pulverize, by 0.8～1.2ml(water)/the g(raw medicinal material) add the water mixing, in quick freezing below 0 ℃, take out to be heated to and boil, repeat quick freezing and be heated to boil three times; Cold after-filtration, collect filtrate, press 1ml(ethanol)/0.75～0.80g(filtering residue) in filtering residue, added 50% alcoholic solution stirring and leaching 24～48 hours, filter, three times repeatedly, merging filtrate, 50 weight portions that camphorate, Borneolum Syntheticum 20 weight portions, Moschus/muscone 0.1 weight portion, stir, make tincture or further make gel, plaster.
8. treat the preparation method of the Chinese medicine for outer use of gout, it is characterized in that: get the Radix Rehmanniae, Fructus Chaenomelis, the Radix Aucklandiae, the Radix Angelicae Dahuricae, Cortex Acanthopancis, Radix Achyranthis Bidentatae, Radix Aconiti Kusnezoffii, each 100～250 weight portion of Pseudobulbus Cremastrae Seu Pleiones, Radix Notoginseng, each 10～40 weight portion of Fructus Foeniculi, pulverize, add alcoholic solution room temperature lixiviate 20～40 days, filter, collect filtrate, camphorate 25～75 weight portions, Borneolum Syntheticum 10～30 weight portions, Moschus/muscone 0.1～0.5 weight portion stir, and make various external preparation.
9. the preparation method of the Chinese medicine for outer use of described according to Claim 8 treatment gout, it is characterized in that: get the Radix Rehmanniae, Fructus Chaenomelis, the Radix Aucklandiae, the Radix Angelicae Dahuricae, Cortex Acanthopancis, Radix Achyranthis Bidentatae, Radix Aconiti Kusnezoffii, each 150 weight portion of Pseudobulbus Cremastrae Seu Pleiones, Radix Notoginseng, each 20 weight portion of Fructus Foeniculi, pulverize, by 3～4ml(ethanol)/the g(raw medicinal material) add 50% alcoholic solution room temperature lixiviate 25～35 days, filter, collect filtrate, 50 weight portions, Borneolum Syntheticum 20 weight portions, Moschus/muscone 0.1 weight portion camphorate, stir, make tincture or further make gel, plaster.
10. according to the preparation method of the Chinese medicine for outer use of claim 7 or 9 described treatment gouts, it is characterized in that: gel is made like this: get the tincture medicinal liquid, under stirring, slowly add an amount of thickening agent, and adding aqueous slkali accent pH value is 5～7, be stirred to no naked eyes visible particle, placement is spent the night, promptly; Plaster is made like this: get the tincture medicinal liquid, and vacuum concentration to 0.1 times volume, it is standby to be prepared into fluid extract; Weight ratio by fluid extract and rubber is 1～3: 10 take by weighing rubber, weight ratio by gasoline and rubber is 1: 0.5～2 adding gasoline soaked overnight swellings, petrol such as adding again stirs, add standby fluid extract, stir, the rubber-emplastrum that stirs is uniformly coated on the cotton, oven dry, cutting, promptly.
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| CN108652974A (en) * | 2018-05-28 | 2018-10-16 | 刘志佳 | A kind of atomization preparation method and atomization device for making |
| CN110946931A (en) * | 2018-09-27 | 2020-04-03 | 宁夏力灵医药有限公司 | Plaster for treating gout and preparation method thereof |
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| CN1824204A (en) * | 2005-12-21 | 2006-08-30 | 苏州市中医医院 | Medicinal composition for treating acute urarthritis and its preparation method |
| CN1954834A (en) * | 2005-10-27 | 2007-05-02 | 上海中医大源创科技有限公司 | Traditional Chinese medicine gels for treating acute gout arthritis |
| CN101062022A (en) * | 2007-05-31 | 2007-10-31 | 天津市中宝制药有限公司 | Colchicine patch absorbing from skin for treating acute goute arthritis and the preparing method thereof |
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| CN1954834A (en) * | 2005-10-27 | 2007-05-02 | 上海中医大源创科技有限公司 | Traditional Chinese medicine gels for treating acute gout arthritis |
| CN1824204A (en) * | 2005-12-21 | 2006-08-30 | 苏州市中医医院 | Medicinal composition for treating acute urarthritis and its preparation method |
| CN101062022A (en) * | 2007-05-31 | 2007-10-31 | 天津市中宝制药有限公司 | Colchicine patch absorbing from skin for treating acute goute arthritis and the preparing method thereof |
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| Title |
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| 南京中医药大学.中药大辞典 第2版.上海科学技术出版社,2006,3663. * |
| 苏文瑞.痛风性关节炎的中医药治疗研究进展.吉林中医药23 11.2003,23(11),53-54. * |
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