CN101234226A - Easy-to-take-out peripheral nerve semi-implantation type electric stimulation electrode and method - Google Patents
Easy-to-take-out peripheral nerve semi-implantation type electric stimulation electrode and method Download PDFInfo
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- CN101234226A CN101234226A CNA2008100329070A CN200810032907A CN101234226A CN 101234226 A CN101234226 A CN 101234226A CN A2008100329070 A CNA2008100329070 A CN A2008100329070A CN 200810032907 A CN200810032907 A CN 200810032907A CN 101234226 A CN101234226 A CN 101234226A
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Abstract
The invention relates to a half-implantation electronic stimulation electrode of peripheral nerves, which can be easily taken out and a method thereof. The invention comprises an electrode guide wire. The end of the electrode guide wire is provided with an electrode which is in direct contact with the nerves; the electrode which is in direct contact with the nerves comprises a point-contact electrode and an arc-contact electrode; the electrode guide wire consists of inert metal elements of nitinol alloy wires or nickel cobalt wires or stainless steel wires and a layer of insulating sleeve wraps the outside of the electrode guide wire. The stimulation electrode and the method thereof have little mechanical damage to the nerves and are convenient in extracting, which can avoid the tedious operations of retaking the electrode in another surgery and reduce the risk of damaging the nerves for a second time.
Description
Technical field
The invention belongs to biomedical engineering field, particularly relate to a kind of electrode and method thereof of intelligent electric boost controller.
Background technology
Along with the fast development of China's industrial economy and communications, the high-energy trauma patient obviously increases, and the peripheral nerve injury very high based on this class disability rate of brachial plexus nerve become common clinical and frequently-occurring disease.To the regeneration behind the peripheral nerve injury, although it is neural to adopt meticulous microsurgical technique to repair at present, use medicine, hormone and nerve growth factor to promote its regeneration, neuranagenesis speed is still undesirable.Electricity irritation is as a kind of physiotherapy, be to utilize the promotion that is used for of electric current to damage peripheral nerve regeneration and prevent that flesh from withering, its effect extensively is subjected to certainly at academia, successively confirms that with a large amount of zooperies electricity irritation can promote obviously that the peripheral nerve regeneration that damages speeds up from Wilson, Pomeranz, Fakhouri, Politis etc. in 1976.Nineteen eighty-three Raji confirms that electric-impulse stimulation can promote Mus sciatic nerve functional rehabilitation, and can increase the diameter of nerve injury section and section regeneration aixs cylinder far away, and accelerator nerve damage section far away Wallerian degeneration improves neuranagenesis speed.Domestic many scholars have also carried out electricity irritation separately and have promoted perineural experiment of damage or clinical research.A large amount of experimentatioies confirms that electricity irritation has the effect that promotes peripheral nerve regeneration.Though electricity irritation at present promotes the damage peripheral nerve regeneration and prevents that the mechanism that flesh withers from not illustrating as yet that its effect is sure, has been widely used in orthopaedics, hands surgery, neurosurgery and rehabilitation section etc.
The stimulation mode of electricity irritation mainly contains two kinds at present: transcutaneous electrostimulation and implantation type electric stimulation.Both respectively have its pluses and minuses.The advantage of transcutaneous electrostimulation is to have avoided the loaded down with trivial details operation of body embedded set electrode and needed operation once more to take out, and the wound that causes of needle electrode, characteristics such as has conveniently, no pain and indication are extensive.But it has following shortcoming: (1) specific aim is not strong, and weak effect mainly is because stimulus intensity is limited, because higher stimulus intensity patient can not feel well, and the possibility of skin scald is arranged; (2) twice stimulus intervals are oversize, because percutaneous stimulation all is to carry out in hospital mostly; (3) patient's compliance is poor.Compare to transcutaneous electrostimulation, the advantage of implant electrode is can round-the-clock lasting stimulation, and because its direct stimulated muscle or nerve, its stimulus intensity can be more much bigger than transcutaneous electrostimulation, also can avoid inconvenience that transcutaneous electrostimulation brings, sense of discomfort and can not pinpoint defective (Osterman).Its shortcoming is the loaded down with trivial details operation of body embedded set electrode and needs operation once more to take out, and electrode itself damages the mechanics that nerve may cause.
Implant electrode is electrode is placed on the nerve trunk to the mechanics infringement of nerve, needs operation free neural, and stimulating electrode is fixed on the nerve.The nervous lesion character that mechanics factor causes is similar substantially, and its mechanism is mainly iatrogenic neural card and presses.Show as the fibrous connective tissue hypertrophy under the epineurium on the histology and form crescent, aixs cylinder regression, disappearance and regeneration appears in the edge nerve tract that blocked pressure.Study carefully the Mechanics of Machinery factor that it causes peripheral lesion, think at present to be divided into following aspect: 1. electrode shape, 2. operation wound, 3. postoperative edema compressing, 4. scar hyperplasia, the 5. tractive tension force of lead is 6. to the infringement of neural blood confession etc.At present the snap ring electrodes (Agnew) that adopt are reported in the nerve trunk electricity irritation in the world.Circular snap ring electrode can be guaranteed the contact area with the nerve trunk maximum, thereby produce bigger field intensity in the part, yet its shortcoming be its cause easily press (too little) or sliding friction repeatedly (too big) to cause proliferation of fibrous tissue to the direct card of nerve as ring as ring after card press, with the infringement to neural blood confession, simultaneously it has operation complex operation and nerve is produced the risk of secondary damage when taking out electrode.Therefore, how reducing the damage of nerve when guaranteeing good effect of stimulation as far as possible and can successfully take out the electrode seal wire becomes the thorny problem that the restriction implantation type electric stimulation is able to extensive use.
Summary of the invention
Technical problem to be solved
Technical problem to be solved by this invention provide a kind of can by electricity irritation promote nerve growth and mechanics infringement that nerve is caused less, it is convenient to extract out, the peripheroneural electric stimulation electrode and the method for avoid performing the operation once more troublesome operation of taking out electrode and the risk that reduces nerve is damaged again.
Technical scheme
The technical solution adopted for the present invention to solve the technical problems is: peripheral nerve semi-implantation type electric stimulation electrode and method thereof that a kind of easy taking-up is provided, comprise the electrode seal wire, and link to each other with electric-stimulation controller by interface convertor, the end of described electrode seal wire be provided with one with neural directly electrodes in contact.
Described and neural directly electrodes in contact comprises some electrodes in contact or arc electrodes in contact.
The electrode that described electrode seal wire is made up of inert metal elemental nickel titanium alloy or nickel cobalt (alloy) or rustless steel, coated outside one deck insulated sleeve.
A kind of method of peripheral nerve semi-implantation type electric stimulation electrode comprises the following steps:
(1) directly finds the position of damaged peripheral nerves wound and carry out micro-reparation by surgical operation;
(2) insert implanted electrode seal wire and contact electrode respectively and be fixed in adjacent tissue in the nearly far-end of the nerve of repairing the position;
(3) cause the electrode seal wire external from skin;
(4) link to each other with electric-stimulation controller by interface convertor, implement electricity irritation;
(5) after electricity irritation finished, closing controller was directly extracted the electrode seal wire out from skin.
Above-mentioned step (2) is to place Nitinol or the nickel cobalt (alloy) and/or the stainless steel electrode of band seal wire at the nearly far-end 0.5cm of anastomotic stoma place; Place the nerve segment near-end of reparation and far-end to form one from the minus electric field of forward respectively the positive and negative electrode of electricity irritation at the nearly far-end of nerve injury.
The seal wire that links to each other with electrode in the above-mentioned step (2) passes spatium intermusculare, passes skin through subcutaneous tunnel, gives 5-0 band needlework with seal wire and spatium intermusculare fascia and skin fixes simultaneously in case the seal wire slippage on every side.
Seal wire is reserved the elasticity distance of 5cm in the above-mentioned step (3) draw skin in body before.
Beneficial effect
The present invention can produce nerve and promote regenerated effect, and the mechanics that causes simultaneously infringement is less, and it is convenient to extract out, the risk of avoiding performing the operation once more and taking out the troublesome operation of electrode and reduce nerve is damaged again.
Description of drawings
Fig. 1 is a schematic diagram of the present invention.
The specific embodiment
Below in conjunction with specific embodiment, further set forth the present invention.Should be understood that these embodiment only to be used to the present invention is described and be not used in and limit the scope of the invention.Should be understood that in addition those skilled in the art can make various changes or modifications the present invention after the content of having read the present invention's instruction, these equivalent form of values fall within the application's appended claims institute restricted portion equally.
The present invention adopts the electrode seal wire to be made up of inert metal element NiTi or the cobaltic alloy silk of nickel or stainless steel silk, makes point-like or arc and neural directly electrodes in contact, seal wire coated outside one deck insulated sleeve at its end.Perusal is general glossy silver gray, this Nitinol or nickel cobalt (alloy) or rustless steel seal wire not only have unique memory function, and have intensity height, nonmagnetic, wear-resisting, endurance, acid and alkali-resistance, the corrosive medium of anti-the human body, belong to good physics, chemical property such as extremely strong level.It is harmless, has excellent biological compatibility and lower biodegradability, and corrosion rate is widely used at medical domain less than 0.001 milligram/year in oral cavity and Physiological Medium.
Press 5ml/1000g to after the SD rats underwent intraperitoneal injection anesthesia with 1% pentobarbital sodium, the operating field sterile drape, longitudinal incision is made in the outside behind thigh, and spatium intermusculare appears sciatic nerve from buttocks thigh portion.From piriformis outlet 1cm place, cut off sciatic nerve with the sterilization razor, coincide in the descending bundle adventitia of microscope with the 9-0prolene microsutures immediately.Experimental group is placed Nitinol or the nickel cobalt (alloy) or the stainless steel electrode of band seal wire at the nearly far-end 0.5cm of anastomotic stoma place, contact with nerve trunk row point respectively or the arc contact.Seal wire passes from the musculus glutaeocruralis gap, reserves suitable length and makes buffering after the back hypodermic tunnel passes from the rat napex, gives 5-0 and admires the silk ribbon needlework with seal wire and spatium intermusculare fascia and napex skin fixes simultaneously in case the seal wire slippage on every side.After marking the both positive and negative polarity of intending stimulating on the nearly distal guide wire of anastomotic stoma, intramuscular injection penicillin injection liquid is successively closed stitching.
The present invention not only can reach gratifying effect of stimulation, and can guarantee the extraction of safe ready ground, need not implement operation once more and take out neural.
When drawing materials after ten weeks in experience rat body, we find that seal wire does not have obvious color and luster and changes, non-cracking, attenuate, evidence of corrosion, the obvious scar tissue adherent at no seal wire conduct position, the necrosis of festering of muscle skin in the rat body.
Claims (7)
1. a peripheral nerve semi-implantation type electric stimulation electrode that easily takes out comprises the electrode seal wire, and links to each other with electric-stimulation controller by interface convertor, it is characterized in that: the end of described electrode seal wire is provided with one and neural directly electrodes in contact.
2. the peripheral nerve semi-implantation type electric stimulation electrode of a kind of easy taking-up according to claim 1 is characterized in that: described and neural directly electrodes in contact comprises some electrodes in contact or arc electrodes in contact.
3. the peripheral nerve semi-implantation type electric stimulation electrode of a kind of easy taking-up according to claim 1 and 2, it is characterized in that: described electrode seal wire is made up of the alloy silk or the stainless steel silk of inert metal elemental nickel titanium alloy or nickel cobalt (alloy), coated outside one deck insulated sleeve.
4. the method for the peripheral nerve semi-implantation type electric stimulation electrode of a kind of easy taking-up according to claim 1 comprises the following steps:
(1) directly finds the position of damaged peripheral nerves wound and carry out micro-reparation by surgical operation;
(2) insert electrode seal wire and contact electrode respectively and be fixed in adjacent tissue in the nearly far-end of the nerve of repairing the position;
(3) cause the electrode seal wire external from skin;
(4) link to each other with electric-stimulation controller by interface convertor, implement electricity irritation;
(5) after electricity irritation finished, closing controller was directly extracted the electrode seal wire out from skin.
5. the method for the peripheral nerve semi-implantation type electric stimulation electrode of a kind of easy taking-up according to claim 4 is characterized in that: described step (2) is to place Nitinol or the nickel cobalt (alloy) or the stainless steel electrode of band seal wire at the nearly far-end 0.5cm of anastomotic stoma place; Place the nerve segment near-end of reparation and far-end to form one from the minus electric field of forward respectively the positive and negative electrode of electricity irritation in the nearly section far away of nerve injury.
6. the method for the peripheral nerve semi-implantation type electric stimulation electrode of a kind of easy taking-up according to claim 4, it is characterized in that: the seal wire that links to each other with electrode in the described step (2) passes spatium intermusculare, pass skin through subcutaneous tunnel, give 5-0 band needlework seal wire and spatium intermusculare fascia and skin fixes simultaneously in case the seal wire slippage on every side.
7. the method for the peripheral nerve semi-implantation type electric stimulation electrode of a kind of easy taking-up according to claim 4 is characterized in that: seal wire is reserved the elasticity distance of 5cm in the described step (3) draw skin in body before.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100329070A CN101234226A (en) | 2008-01-22 | 2008-01-22 | Easy-to-take-out peripheral nerve semi-implantation type electric stimulation electrode and method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100329070A CN101234226A (en) | 2008-01-22 | 2008-01-22 | Easy-to-take-out peripheral nerve semi-implantation type electric stimulation electrode and method |
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| CN101234226A true CN101234226A (en) | 2008-08-06 |
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| CNA2008100329070A Pending CN101234226A (en) | 2008-01-22 | 2008-01-22 | Easy-to-take-out peripheral nerve semi-implantation type electric stimulation electrode and method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110721402A (en) * | 2018-07-16 | 2020-01-24 | 上海交通大学 | Implanted nerve electrode system |
| CN111491691A (en) * | 2017-07-28 | 2020-08-04 | 加尔瓦尼生物电子有限公司 | Electrode device for nerve stimulation |
-
2008
- 2008-01-22 CN CNA2008100329070A patent/CN101234226A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111491691A (en) * | 2017-07-28 | 2020-08-04 | 加尔瓦尼生物电子有限公司 | Electrode device for nerve stimulation |
| CN111491691B (en) * | 2017-07-28 | 2024-02-02 | 加尔瓦尼生物电子有限公司 | Electrode device for nerve stimulation |
| CN110721402A (en) * | 2018-07-16 | 2020-01-24 | 上海交通大学 | Implanted nerve electrode system |
| CN110721402B (en) * | 2018-07-16 | 2023-11-21 | 上海交通大学 | Implantable neural electrode system |
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Open date: 20080806 |