CN101229050A - Method of marking internal lesions position and marking agent - Google Patents
Method of marking internal lesions position and marking agent Download PDFInfo
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- CN101229050A CN101229050A CNA2008100693828A CN200810069382A CN101229050A CN 101229050 A CN101229050 A CN 101229050A CN A2008100693828 A CNA2008100693828 A CN A2008100693828A CN 200810069382 A CN200810069382 A CN 200810069382A CN 101229050 A CN101229050 A CN 101229050A
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- labeling method
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Abstract
The invention discloses a marking method and a marking agent for a focal position in a body. The marking method can utilize an endoscope device and a tool device being able to realize remote control that are connected mutually to apply the marking agent on the focal position, can find out the focal position in the body and simultaneously apply an accurate locating marker on the focal position to provide instruction for the next treatment so as to improve the operation efficiency and the cure rate of a disease. The marking agent of the invention has the advantages of developing in and out of the body, being identified by naked eyes and resisting oxidation and corrosion of liquid. Applying the marking agent on the focal position results in a remarkable sediment after coloration, thus being convenient for a doctor to find out the focal position accurately by visual in the body and be able to confirm a dissection position for the focal position through an exosomatic apparatus; thereby leading the doctor to clearly know the focal position before and during the operation, thus being beneficial to improve the efficiency of the operation and other cure methods. The marking agent of the invention can exit for a long time in the body, thus being convenient for the smoothness of the operation and other treatments.
Description
Technical field
The present invention relates to a kind of method of searching internal lesions position, particularly the labeling method at human body alimentary canal inner disease foci position and markers thereof.
Background technology
The capsule endoscope that last century, the eighties was born is that gastral medical diagnosis on disease has brought important breakthrough.Being used for clinical at present mainly is capsule endoscope, is made up of a miniature camera, digital processing system, wireless transmission system etc., and combines with the image analysing computer processing system, to finish intravital image check.Have volume little, in light weight, check convenience, no wound, no pain, no cross infection, do not influence advantage such as person under inspection's operate as normal.The capsule endoscope of prior art is the function that realization is searched focus, focus is implemented telltale mark.The doctor only diagnoses according to the image that capsule endoscope is clapped, and the clinical experience that still relies on the doctor is to a great extent judged the state of an illness, causes mistaken diagnosis easily or fails to pinpoint a disease in diagnosis.
If find out focus, the diseased region of the treatment that need further operate when operating, also needs operative doctor to carry out visual search diseased region again.And the position in vivo of the diseased region of estimating according to the capsule endoscope image often differs 30 to 50 centimeters with the position in vivo at actual lesion position, serves inconvenience to surgical band, increases the patient suffering, reduces success rate of operation and clinical cure rate.
Therefore, need a kind ofly can to implement specifically labelled method to lesions position when in human body, finding out focus,, improve success rate of operation and clinical cure rate for next step treatment provides accurate guide; Need labelling can resist oxidation and corrosion in the human body with markers, painted back deposition is obvious, and has development and the discernible characteristics of naked eyes.
Summary of the invention
In view of this, the purpose of this invention is to provide a kind of labeling method and markers thereof that can show internal lesions position in vivo and in vitro, when promptly can find out focus in vivo lesions position is implemented external positioning mark, for next step clinical treatment provides accurate guide, improve success rate of operation and clinical cure rate; Need labelling can resist oxidation and corrosion in the human body with markers, painted back deposition is obvious, and has development and the discernible characteristics of naked eyes.
The labeling method of internal lesions position of the present invention, utilize interconnected endoscope and image processing device and can realize that the tool device of external control imposes on lesions position with markers, may further comprise the steps:
A. in tool device, add an amount of markers;
B. endoscope and image processing device and tool device are positioned in the body, it is moved in vivo;
C. the image that utilizes endoscope and image processing device to spread out of is determined lesions position;
D. by external control, markers is imposed on lesions position.
Further, also comprise driving device, described driving device is used to drive endoscope and image processing device and tool device moves in human body, and driving device and endoscope and image processing device and tool device are interconnection;
Further, described tool device is a tool capsule;
Further, described driving device and endoscope and image processing device be respectively drive capsule and in peep capsule;
Further, described endoscope and image processing device is an endoscope, and the mode that markers adopts tool device to set up biopsy channel identifies;
Further, described markers has and directly shows in the body and to the characteristics of the high decay property of X line;
The invention also discloses a kind of markers of labeling method use of internal lesions position, comprise following component by volume: india ink 0.15-1, iodized oil 0.15-1.
Further, markers comprises following component by volume: india ink 0.38-1, iodized oil 0.38-1;
Further, markers comprises following component by volume: india ink 1, iodized oil 1.
Beneficial effect of the present invention: the labeling method of internal lesions position of the present invention, lesions position is implemented accurate telltale mark when can in human body, find out focus, for next step treatment provides accurate guide, improve the cure rate of operation efficient and disease; Markers of the present invention has and directly shows in the body and to the characteristics of the high decay property of X line, use this markers at diseased region, painted back deposition obviously, be convenient to the doctor and can pass through visual definite diseased region in vivo, and can be by the anatomical position of the clear and definite diseased region of external instrument (X-ray machine), thereby make the clinician before operation and in the operation, can both know diseased region, be beneficial to the efficient that improves operation and other treatment method; Markers of the present invention can be resisted the oxidation and the corrosion of body fluid, and life period is long in vivo, is beneficial to carrying out smoothly of operation and other treatment; The labeling method of internal lesions position of the present invention and markers thereof not only can be used for clinical capsule endoscope, can also be used for other clinical endoscope, such as: gastroscope, rectoscope, cystoscope, metroscope or the like.
The specific embodiment
Below be markers embodiment:
Markers embodiment one
Get india ink 10ml, iodized oil 1.5ml mixes, and india ink and iodized oil volume ratio are 1: 0.15.
Markers embodiment two
Get india ink 10ml, iodized oil 2.4ml mixes, and india ink and iodized oil volume ratio are 1: 0.24.
Markers embodiment three
Get india ink 10ml, iodized oil 3.8ml mixes, and india ink and iodized oil volume ratio are 1: 0.38.
Markers embodiment four
Get india ink 10ml, iodized oil 6.2ml mixes, and india ink and iodized oil volume ratio are 1: 0.62.
Markers embodiment five
Get india ink 10ml, iodized oil 10ml mixes, and india ink and iodized oil volume ratio are 1: 1.
Markers embodiment six
Get india ink 6.2ml, iodized oil 10ml mixes, and india ink and iodized oil volume ratio are 0.62: 1.
Markers embodiment seven
Get india ink 3.8ml, iodized oil 10ml mixes, and india ink and iodized oil volume ratio are 0.38: 1.
Markers embodiment eight
Get india ink 2.4ml, iodized oil 10ml mixes, and india ink and iodized oil volume ratio are 0.24: 1.
Markers embodiment nine
Get india ink 1.5ml, iodized oil 10ml mixes, and india ink and iodized oil volume ratio are 0.15: 1.
The laboratory animal of following examples is that body weight is 60 kilograms of tame pigs.
The labeling method embodiment one of internal lesions position of the present invention:
Utilize and peep capsule, can realize remotely-controlled tool capsule and internally peep capsule in interconnected and driving capsule that tool capsule drives imposes on lesions position with markers, may further comprise the steps:
A. in tool capsule, add to have in right amount and directly show in the body and the markers of the high decay property of X line characteristics;
B. with tame pig deep anaesthesia, will in peep capsule, tool capsule and driving capsule and be positioned over and need to search the position in the body, such as, digestive system, urinary system, reproductive system etc., present embodiment is a digestive tract, drives capsule by external control it is moved in digestive tract;
C. peep the clear and definite lesions position of image that capsule spreads out of in utilizing, certainly, can in enteric cavity, select in the experimentation cleaner one section as the test block;
D. by external control tool capsule, above-mentioned markers is imposed on lesions position or test block;
E. utilize the painted situation of X-ray production apparatus fluoroscopic observation markers;
The labeling method embodiment two of internal lesions position of the present invention:
Utilize endoscope and parallel with it tool device that markers is imposed on lesions position, may further comprise the steps:
A. in tool device, add to have in right amount and directly show in the body and the markers of the high property characteristics that decay of X line;
B. with tame pig deep anaesthesia, make endoscope enter enteric cavity, select cleaner enteric cavity as the test block by anus;
C. above-mentioned markers is injected in the intestinal wall mucosa of enteric cavity test block respectively by biopsy channel;
D. utilize the painted situation of X-ray production apparatus fluoroscopic observation markers.
More than in the experiment, when india ink and iodized oil volume ratio in following scope: india ink 0.38-1, during iodized oil 0.38-1, painted back deposition obviously; When india ink and iodized oil volume ratio less than 0.38: 1 and iodized oil and india ink volume ratio during less than 0.38: 1, deposition is obviously after painted back 24 hours.
Explanation is at last, above embodiment is only unrestricted in order to technical scheme of the present invention to be described, although the present invention is had been described in detail with reference to preferred embodiment, those of ordinary skill in the art is to be understood that, can carry out the modification in the parameter area or be equal to replacement technical scheme of the present invention, and not breaking away from the aim and the scope of technical solution of the present invention, it all should be encompassed in the middle of the claim scope of the present invention.
Claims (11)
1. the labeling method of an internal lesions position is characterized in that: utilize interconnected endoscope and image processing device and can realize that the tool device of external control imposes on lesions position with markers, may further comprise the steps:
A. in tool device, add an amount of markers;
B. endoscope and image processing device and tool device are positioned in the body, it is moved in vivo;
C. the image that utilizes endoscope and image processing device to spread out of is determined lesions position;
D. by external control, markers is imposed on lesions position.
2. the labeling method of internal lesions position according to claim 1, it is characterized in that: also comprise driving device, described driving device is used to drive endoscope and image processing device and tool device moves in human body, and driving device and endoscope and image processing device and tool device are interconnection.
3. the labeling method of internal lesions position according to claim 1 and 2, it is characterized in that: described tool device is a tool capsule.
4. the labeling method of internal lesions position according to claim 3 is characterized in that: described driving device and endoscope and image processing device be respectively drive capsule and in peep capsule.
5. the labeling method of internal lesions position according to claim 1 and 2, it is characterized in that: described endoscope and image processing device is an endoscope, the mode that markers adopts tool device to set up biopsy channel identifies.
6. according to the labeling method of claim 1 or 2 or 4 described internal lesions positions, it is characterized in that: described markers has and directly shows in the body and to the characteristics of the high decay property of X line.
7. the labeling method of internal lesions position according to claim 3 is characterized in that: described markers has and directly shows in the body and to the characteristics of the high decay property of X line.
8. the labeling method of internal lesions position according to claim 5 is characterized in that: described markers has and directly shows in the body and to the characteristics of the high decay property of X line.
9. the markers of the labeling method of the described internal lesions position of claim 1 use comprises following component: india ink 0.15-1, iodized oil 0.15-1 by volume.
10. the markers of the labeling method of internal lesions position according to claim 9 use is characterized in that: comprise following component by volume: india ink 0.38-1, iodized oil 0.38-1.
11. the markers that the labeling method of internal lesions position according to claim 10 is used is characterized in that: comprise following component by volume: india ink 1, iodized oil 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100693828A CN101229050A (en) | 2008-02-21 | 2008-02-21 | Method of marking internal lesions position and marking agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100693828A CN101229050A (en) | 2008-02-21 | 2008-02-21 | Method of marking internal lesions position and marking agent |
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| Publication Number | Publication Date |
|---|---|
| CN101229050A true CN101229050A (en) | 2008-07-30 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNA2008100693828A Pending CN101229050A (en) | 2008-02-21 | 2008-02-21 | Method of marking internal lesions position and marking agent |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104939794B (en) * | 2015-07-15 | 2016-06-01 | 吉林大学第一医院 | Digestive tract lesion endoscope positioning device |
| CN106377221A (en) * | 2016-10-31 | 2017-02-08 | 中国人民解放军第二军医大学 | Radial scanning type capsule endoscopy applied to digestive tract pathologic change screening and application thereof |
| CN106419942A (en) * | 2016-10-31 | 2017-02-22 | 中国人民解放军第二军医大学 | Capsule endoscopy for screening alimentary canal protuberant lesions, and application thereof |
-
2008
- 2008-02-21 CN CNA2008100693828A patent/CN101229050A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104939794B (en) * | 2015-07-15 | 2016-06-01 | 吉林大学第一医院 | Digestive tract lesion endoscope positioning device |
| CN106377221A (en) * | 2016-10-31 | 2017-02-08 | 中国人民解放军第二军医大学 | Radial scanning type capsule endoscopy applied to digestive tract pathologic change screening and application thereof |
| CN106419942A (en) * | 2016-10-31 | 2017-02-22 | 中国人民解放军第二军医大学 | Capsule endoscopy for screening alimentary canal protuberant lesions, and application thereof |
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Open date: 20080730 |