CN101228155B - 作为代谢型谷氨酸受体的正变构调节剂的取代的*二唑衍生物 - Google Patents
作为代谢型谷氨酸受体的正变构调节剂的取代的*二唑衍生物 Download PDFInfo
- Publication number
- CN101228155B CN101228155B CN2006800252307A CN200680025230A CN101228155B CN 101228155 B CN101228155 B CN 101228155B CN 2006800252307 A CN2006800252307 A CN 2006800252307A CN 200680025230 A CN200680025230 A CN 200680025230A CN 101228155 B CN101228155 B CN 101228155B
- Authority
- CN
- China
- Prior art keywords
- fluoro
- phenyl
- diazole
- piperidines
- ketone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- BTOBLUWDUNIIJD-LBPRGKRZSA-N O=C(c(c(F)ccc1)c1F)N(CCC1)C[C@H]1c1n[o]c(-c2ncccc2)n1 Chemical compound O=C(c(c(F)ccc1)c1F)N(CCC1)C[C@H]1c1n[o]c(-c2ncccc2)n1 BTOBLUWDUNIIJD-LBPRGKRZSA-N 0.000 description 1
- RIDRZVBAGKUTSN-LBPRGKRZSA-N O=C(c(cc1)cc(F)c1F)N(CCC1)C[C@H]1c1n[o]c(-c(cc2)ncc2F)n1 Chemical compound O=C(c(cc1)cc(F)c1F)N(CCC1)C[C@H]1c1n[o]c(-c(cc2)ncc2F)n1 RIDRZVBAGKUTSN-LBPRGKRZSA-N 0.000 description 1
- SDQGSRQCLAPKJG-AWEZNQCLSA-N O=C(c(cc1)ccc1F)N(CCC1)C[C@H]1c1n[o]c(-c2ncccc2)n1 Chemical compound O=C(c(cc1)ccc1F)N(CCC1)C[C@H]1c1n[o]c(-c2ncccc2)n1 SDQGSRQCLAPKJG-AWEZNQCLSA-N 0.000 description 1
- RSTNDKZTQBZOCY-UHFFFAOYSA-N O=C(c(cc1)cnc1F)N(CCC1)CC1c1n[o]c(-c(cc2)ccc2F)n1 Chemical compound O=C(c(cc1)cnc1F)N(CCC1)CC1c1n[o]c(-c(cc2)ccc2F)n1 RSTNDKZTQBZOCY-UHFFFAOYSA-N 0.000 description 1
- RZKPASPGSLBRFH-UHFFFAOYSA-N O=C(c(ccc(F)c1)c1F)N(CCC1)CC1c1n[o]c(-c2ccccc2)n1 Chemical compound O=C(c(ccc(F)c1)c1F)N(CCC1)CC1c1n[o]c(-c2ccccc2)n1 RZKPASPGSLBRFH-UHFFFAOYSA-N 0.000 description 1
Images
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0510138A GB0510138D0 (en) | 2005-05-18 | 2005-05-18 | Novel compounds A4 |
| GB0510138.1 | 2005-05-18 | ||
| GB0601709.9 | 2006-01-27 | ||
| GBGB0601709.9A GB0601709D0 (en) | 2006-01-27 | 2006-01-27 | Novel compounds A4 |
| PCT/IB2006/001881 WO2006123255A2 (en) | 2005-05-18 | 2006-05-17 | Substituted oxadiazole derivatives as positive allosteric modulators of metabotropic glutamate receptors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101228155A CN101228155A (zh) | 2008-07-23 |
| CN101228155B true CN101228155B (zh) | 2012-01-11 |
Family
ID=34708376
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2006800252307A Expired - Fee Related CN101228155B (zh) | 2005-05-18 | 2006-05-17 | 作为代谢型谷氨酸受体的正变构调节剂的取代的*二唑衍生物 |
Country Status (4)
| Country | Link |
|---|---|
| CN (1) | CN101228155B (ru) |
| GB (1) | GB0510138D0 (ru) |
| UA (1) | UA92495C2 (ru) |
| ZA (1) | ZA200710278B (ru) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023122152A1 (en) * | 2021-12-22 | 2023-06-29 | Praxis Precision Medicines, Inc. | Kcnt1 inhibitors and methods of use |
-
2005
- 2005-05-18 GB GB0510138A patent/GB0510138D0/en not_active Ceased
-
2006
- 2006-05-17 UA UAA200714065A patent/UA92495C2/ru unknown
- 2006-05-17 CN CN2006800252307A patent/CN101228155B/zh not_active Expired - Fee Related
-
2007
- 2007-11-28 ZA ZA200710278A patent/ZA200710278B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101228155A (zh) | 2008-07-23 |
| UA92495C2 (ru) | 2010-11-10 |
| ZA200710278B (en) | 2009-12-30 |
| GB0510138D0 (en) | 2005-06-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120111 Termination date: 20120517 |