CN101210913A - Substance quantitative analysis method - Google Patents
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- CN101210913A CN101210913A CNA200710307532XA CN200710307532A CN101210913A CN 101210913 A CN101210913 A CN 101210913A CN A200710307532X A CNA200710307532X A CN A200710307532XA CN 200710307532 A CN200710307532 A CN 200710307532A CN 101210913 A CN101210913 A CN 101210913A
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Abstract
The invention provides a quantitative substance analysis method, which comprises the following steps of: analyzing at least two calibrated substances by a mass spectral analysis device to obtain the analysis results, wherein each calibrated substance contains a first substance component with known concentration and a second substance component with known concentration; analyzing a substance to be detected containing the first substance component with known concentration and the second substance component by the mass spectral analysis device; and calculating the concentration of the second substance component of the substance to be detected according to the concentration of the first substance component of the substance to the detected and the analysis results.
Description
[technical field]
The present invention relates to a kind of substance quantitative analysis method, especially a kind of substance quantitative analysis method that utilizes mass spectrometer.
[background technology]
Chromatographic analysis device is to utilize chromatographic column that the various compositions in the measured matter are separated, and measures the concentration of described each composition simultaneously, and analysis precision height, analysis speed are slow.Chromatographic analysis device mainly comprises gas chromatographic analysis device (GC) and liquid chromatography system (LC), mainly is used to material is carried out quantitative test, promptly the concentration of each composition in the measured matter is analyzed.
Mass spectrometer (Mass spectrograph is called for short MS) mainly is used to measured matter is carried out qualitative analysis, promptly the character of each composition in the measured matter is analyzed.
Chromatogram/mass spectrum overall analysis system has in the analytical chemistry field widely to be used.It at first utilizes chromatographic analysis device that the measured matter sample is separated, and each material composition that separation is obtained carries out quantitative test simultaneously; Utilize mass spectrometer that each material composition that separation obtains is carried out qualitative analysis again.Similarly application can be with reference to No. the 4213326th, United States Patent (USP).
Yet, critical component chromatographic column in the chromatographic analysis device is not all effective to all substances composition, sometimes need the parallel or serial of two kinds of chromatographic columns to use and to analyze measured matter fully, and will find sometimes the unusual difficulty of the effective chromatographic column of a certain material composition.
In addition, for some corrosive substances (such as organic acid), be difficult to utilize chromatographic analysis device directly it to be carried out quantitative test, because corrosion can cause the chromatographic analysis device instability.For organic acid, at present known analytical approach be first with its esterification, and the product after utilizing chromatographic analysis device to esterification again carries out quantitative test.The process of this analytical approach is comparatively complicated, and is difficult to be implemented in line analysis, therefore has bigger limitation.
The primary product that synthesizes the reaction of carbon two oxygenatedchemicalss with synthetic gas is ethanol, acetaldehyde and acetate, because acetate has corrosivity, therefore utilizes existing method to carry out on-line analysis to the product of this reaction.
In view of above reason, need design a kind of to the effective online substance quantitative analysis method of corrosive substance.
[summary of the invention]
If the operating conditions of mass spectrometer remains unchanged, the fluctuation of the concentration ratio of two kinds of material compositions keeps within the specific limits in the tested sample, so, the ion that is produced by described two kinds of material compositions in the mass spectrophotometry process is roughly linear with the concentration of described two kinds of material compositions by the probability that mass spectrometer ion collection device detects.Therefore, if described two kinds of material compositions are first material composition and second material composition, as long as the linear relationship between the concentration of the corresponding measured value of the concentration of finding out second material composition and mass spectrometer and first material composition, and the concentration of first material composition in the acquisition tested sample just can utilize mass spectrometer that second material composition in this sample is carried out quantitative test.
One embodiment of the invention provide a kind of substance quantitative analysis method, have advantage applied widely and that analysis speed is fast.
The method that the gaseous material that an aspect of of the present present invention provides a kind of on-line quantitative analysis to comprise first material composition and second material composition flows, wherein, second material composition is a corrosive substance, said method comprising the steps of: preparation N part comprises the demarcation sample of first material composition and second material composition, wherein N is the natural number greater than 1, and described N part is demarcated the concentration ratio difference of first material composition of sample to second material composition; Analyze described N part with a mass spectrometer and demarcate sample, obtain to demarcate corresponding N relevant first material composition of group of sample and the measured value of second material composition with described N part; From described gaseous material stream, gather one first tested sample; Analyze described first tested sample with mass spectrometer, obtain corresponding to relevant its first material composition that is comprised of this first tested sample and the measured value of second material composition; Obtain the concentration of first material composition in described first tested sample; Utilize the concentration of first material composition in described first tested sample, the measured value of relevant first material composition of described N group and second material composition, and the concentration that calculates second material composition in this first tested sample corresponding to the measured value of relevant its first material composition that is comprised of this first tested sample and second material composition.
Further, described method also comprises utilizes described N part to demarcate first material composition and the concentration of second material composition and the measured value of described N relevant first material composition of group and second material composition in the sample, set up the linear relationship of the second material composition concentration and the measured value of the first material composition concentration, relevant first material composition and second material composition, wherein, the concentration of second material composition in the described tested sample is to calculate according to the concentration of first material composition in this linear relationship and the described measured matter to get.
Further, the concentration of first material composition is known and keeps constant in the described tested sample.
Further, first material composition and second material composition can produce first ion and second ion in mass spectrometer, and the measured value of relevant first material composition of N group and second material composition comprises the first ion measured value and the second ion measured value.
Further, to analyze the measured matter ion measured value of winning be characteristic peak to mass spectrometer.
Further, the mass spectrometer analysis measured matter gained second ion measured value is a characteristic peak.
[description of drawings]
Fig. 1 is for utilizing substance quantitative analysis method of the present invention to analyze the equipment connection diagram of measured matter in conjunction with mass spectrometer and chromatographic analysis device.
Fig. 2 prepares the equipment connection diagram of demarcating material for the present invention.
Fig. 3 is the process flow diagram of the method for quantitative test gaseous material of the present invention.
[specific embodiment]
For ease of explanation, in the present patent application gas and steam are referred to as gaseous material.
Concentration of mentioning among the present invention and content are meant volumetric molar concentration and molar content, and wherein, concentration can be load per unit of volume, also can be the numerical value linear with load per unit of volume, such as the measured value of chromatographic analysis device.
Please join Fig. 3, the method 100 that the gaseous material that an aspect of of the present present invention provides a kind of quantitative test to comprise first material composition and second material composition flows, it may further comprise the steps: step 101, preparation N part comprises the demarcation sample of first material composition and second material composition, wherein N is the natural number greater than 1, and described N part is demarcated the concentration ratio difference of first material composition of sample to second material composition; Step 103 is analyzed described N part with a mass spectrometer and is demarcated sample, obtains to demarcate corresponding N relevant first material composition of group of sample and the measured value of second material composition with described N part; Step 105 is gathered one first tested sample from described gaseous material stream; Step 107 is analyzed described first tested sample with mass spectrometer, obtains corresponding to relevant its first material composition that is comprised of this first tested sample and the measured value of second material composition; Step 109 obtains the concentration of first material composition in described first tested sample; Step 111, utilize the concentration of first material composition in described first tested sample, the measured value of relevant first material composition of described N group and second material composition, and the concentration that calculates second material composition in this first tested sample corresponding to the measured value of relevant its first material composition that is comprised of this first tested sample and second material composition.
Further, described method 100 also comprises utilizes described N part to demarcate first material composition and the concentration of second material composition and the measured value of described N relevant first material composition of group and second material composition in the sample, set up the linear relationship of the second material composition concentration and the measured value of the first material composition concentration, relevant first material composition and second material composition, wherein, the concentration of second material composition in the described tested sample is to calculate according to the concentration of first material composition in this linear relationship and the described measured matter to get.Demarcate first material composition of materials and the concentration of second material composition, the corresponding first ion measured value and the second ion measured value according to described at least two parts, and following equation one carries out linear regression and calculates, draw out coefficient k and λ,
Equation one:
In the above equation one, D
1The concentration of first material composition in the material, D are demarcated in expression
2The concentration of second material composition in the material, I are demarcated in expression
1The first ion measured value of material, I are demarcated in expression
2The second ion measured value of material is demarcated in expression.
Further, can adopt the whole bag of tricks to carry out linear regression and calculate,, also can adopt ready-made instrument to carry out linear regression and calculate, such as the Excel Software tool of Microsoft such as least square method.
Further, described substance quantitative analysis method can be used for analyzing gaseous material; Also can be used for the analyzing liquid material, during the analyzing liquid material, general elder generation sends into mass spectrometer analysis again to tested liquid gasification substance.
Further, except that described first material composition and second material composition, can also comprise other material compositions in the described demarcation material.Such as, it is identical with measured matter to demarcate the material composition that material comprised, for example, comprise first material composition, the second material composition, the 3rd material composition and four kinds of material compositions of the 4th material composition in the measured matter, also comprise first material composition, the second material composition, the 3rd material composition and four kinds of material compositions of the 4th material composition in the demarcation material.For another example, except that described first material composition and second material composition, demarcate material and also comprise one the 5th material composition, certainly, also can replace the 3rd material composition and the 4th material composition by the 3rd material composition to replace the 3rd material composition and the 4th material composition.
Further, first material composition in the described demarcation material is remained in the measured matter within the fluctuation range of first material composition to the concentration ratio of second material composition to the concentration ratio of second material composition.Described fluctuation range can be estimated according to specific circumstances.
On the other hand, first material composition in the measured matter is remained on demarcates in the material within the drop of first material composition to the concentration ratio of second material composition the fluctuation of the concentration ratio of second material composition.
Further, also can adopt multipoint method to demarcate, demarcate material for three parts, to improve the degree of accuracy of demarcating such as preparation.
Further, in order to guarantee better linearity, comparative optimization, first material composition remains within 50% the fluctuation range of the concentration ratio of second material composition, and promptly the difference of the maximal value of ratio and minimum value and their mean value is less than 50% of described mean value.Preferred, first material composition remains within 30% the fluctuation range of the concentration ratio of second material composition.
Further, in one embodiment, the concentration of first material composition is known in the measured matter, utilizes the measured value of the concentration of the first known material composition and first ion that is obtained by the mass spectrometer analysis and second ion to calculate the concentration of second material composition.Such as, measured matter is gaseous material stream or fluent meterial stream, wherein, the flow of first material composition in this gaseous material stream or fluent meterial stream remains unchanged.Again such as, measured matter is a gaseous material or fluent meterial sample, adds a certain amount of first material composition therein.
In yet another embodiment, the concentration of first material composition is unknown in the measured matter, analyze earlier the concentration of first material composition, utilize the measured value of the concentration of aforementioned first material composition that obtains and first ion that obtains by the mass spectrometer analysis and second ion to calculate the concentration of second material composition again with chromatographic analysis device.Please join Fig. 1, measured matter 24 is divided into two-way through fluid distributor 20, and one the tunnel enters mass spectrometer 21 analyzes, and another road enters sampling apparatus 22, analyzes by sending into chromatographic analysis device 23 after sampling apparatus 22 samplings.
Further, described substance quantitative analysis method is particularly useful for analyzing gaseous material stream, particularly first material composition gaseous material stream little to the concentration ratio fluctuation range of second material composition.Such as, can be used for analyzing the product (comprise reaction product, also may comprise unreacted reactant, also may comprise carrying object etc.) of the reaction of stable state, further, can be used for analyzing the product of the catalytic reaction after stable, thus the activity of evaluate catalysts.
The described first ion measured value and the second ion measured value are meant first ion that produced by first material composition and the measured value of second ion that produced by second material composition, they may be directly to be detected by mass spectrometer to obtain, and also may be to calculate gained by the measured value process of mass spectrometer.
Further, in one embodiment, the described first ion measured value and the second ion measured value are characteristic peak, can be directly used in calculating.
In yet another embodiment, the described first ion measured value or (with) the second ion measured value also can be through calculating.Such as, by carbon dioxide (CO
2) and the gaseous material that forms of carbon monoxide (CO), will detect CO if send into mass spectrometer
2, CO, C, O ion, if obtain the contribution to the detected carbon ion measured value of mass spectrometer of the carbon ion that produced by carbon monoxide, promptly the carbon ion measured value of carbon monoxide can calculate by the following method.
Suppose D
Co2Be gas concentration lwevel, D
CoBe carbonomonoxide concentration, k
Co2Be the contribution coefficient of carbon dioxide to carbon ion, k
CoBe the contribution coefficient of carbon monoxide to carbon ion, I
cBe the carbon ion measured value of mass spectrometer, following equation two just arranged,
Equation two: D
Co2K
Co2+ D
CoK
Co=I
c
Wherein, D
Co2And D
CoFor known, I
cDetect gained by mass spectrometer, two unknown number k are arranged in the equation two
1And k
2, need two groups of data just can solve k
Co2And k
CoAt this moment, can the concentration ratio of carbon dioxide and carbon monoxide obtain two groups of data in the described gaseous material by changing, solve k
Co2And k
CoCalculate the carbon ion measured value of carbon monoxide according to following equation three,
Equation three: D
CoK
Co=I
Co,
Wherein, in the aforesaid equation three, I
CoThe carbon ion measured value of expression carbon monoxide.
Below just illustrate the ion measured value that how to calculate non-characteristic peak, how in the process of demarcating, to calculate contribution coefficient, be used for later concentration and calculate.
Further, described measured matter can also comprise the 3rd material composition, described demarcation material also comprises the 3rd material composition, with described first material composition is reference, described second material composition and the 3rd material composition are carried out quantitative test, as long as kept within limits by of the concentration ratio fluctuation of the material composition of quantitative test to first material composition of conduct reference.Certainly, can also comprise more material composition in the measured matter, as long as these material compositions keep within limits the concentration ratio fluctuation of first material composition of conduct reference, just can utilize mass spectrometer that it is carried out quantitative test by method of the present invention.
Further, described measured matter comes autoreactor, and this reactor comprises the output port that is used to import the input port of reaction raw materials and carrier (such as carrier gas) and is used for the output-response product, and described measured matter is collected from described output port.By described substance quantitative analysis method the measured matter of collecting from described reactor output port is carried out quantitative test, characterize quality, the quality of technology and the performance of catalyzer etc. of prescription.
Further, described reactor is the reactor in the high-throughput reaction system, and this high-throughput reaction system comprises an above reactor.Because mass spectrophotometry speed is fast, therefore, can satisfy the analysis of high flux reaction.
Another aspect of the present invention provides a kind of substance quantitative analysis method, wherein, measured matter comprises first material composition and second material composition, ionization cavity through mass spectrometer, first material composition will produce first ion, second material composition will produce second ion, and it may further comprise the steps:
The first step, prepare at least two parts and demarcate material, each part demarcated material and all comprised first material composition and second material composition, and first material composition is to the concentration ratio difference of second material composition in each part demarcation material, analyze described at least two parts with mass spectrometer and demarcate material, obtain at least two groups first ion measured value and the second ion measured value;
In second step, calculate the linear relationship between the second material composition concentration and the first material composition concentration, the first ion measured value and the second ion measured value;
The 3rd step, the concentration of first material composition in the acquisition measured matter; Analyze measured matter with mass spectrometer and obtain the first ion measured value and the second ion measured value;
The 4th step, according to the second second material composition concentration that obtains of step and the relation between the first material composition concentration, the first ion measured value and the second ion measured value, and concentration, the first ion measured value of demarcation material and the concentration that the second ion measured value calculates second material composition in the measured matter of first material composition in the measured matter that obtains of the 3rd step.
Further, the equipment among the present invention (as mass spectrometer, chromatographic analysis device and sampling apparatus etc.) can be carried out automatically by computer system control, and data processing (such as the collection of measured value and calculating etc.) also can be finished by computer system.
Further, described computer system (as server system) is meant computing machine or the computer-readable media that designs and be disposed for carrying out part or all of method described in the invention.Here the computing machine of Cai Yonging (as server) can be the computing machine of any polytype general applications, as PC, the webserver, workstation or other computer platform of development now or in the future.Known in the art, computing machine include especially as processor, operating system, computer memory, input equipment and these parts of output device partly or entirely.Computing machine can further comprise as cache memory, data backup unit and some miscellaneous equipments.Persons skilled in the art are appreciated that these machine elements can have many other possible structures.
Here the processor that is adopted can comprise one or more microprocessors, territory programmable logic array (FPGA), or one or more special integrated circuit corresponding to the special type application.For example, processor includes but not limited to the Pentium series processors of Intel company, the processor of AMD, the microprocessor of Sun Microsystems, the workstation system processor of Sun Microsystems, the personal desktop machine processor of Motorola Inc., the MIPs processor of MIPS Science and Technology Ltd., the highest serial territory programmable logic array and some other processor of Xilinx company.
Here the operating system that is adopted comprises machine code, by the execution of processor, can coordinate and object computer in the function of other parts, and help processor to carry out the function of the various computing machine program that may write with multiple program language.The data stream of other parts, operating system also provides scheduling arrangement, input and output control, file data management, memory management and Communication Control and related service in supervisory computer, and all these is a prior art.Unix that typical operating system comprises Windows as Microsoft, provided by all multi-providers or (SuSE) Linux OS, other or the operating system of development in the future, and the combination of these operating systems.
Here the computer memory that is adopted dissimilar memory storage arbitrarily.For example comprise optical mediums such as the random access memory that is seen everywhere, permanent hard disk or tape equimagnetic medium memory, read-write compact disc, or other accessing storage devices.Memory storage can be any one device existing or that develop in the future, comprises compact disc driver, tape drive, removable hard disk drive or disc driver.The memory storage of these types generally is to be read or written to from computer program memory medium in this medium, as CD, tape, removable hard disk or floppy disk.All these computer program memory mediums can be considered to the product of computer program.The product of these computer programs common storage computation machine software program and/or data.Computer software programs generally are stored in system storage and/or the memory storage.
Persons skilled in the art readily understand, thereby the computer software programs among the present invention can be by coming execution in loading system storer and/or the memory storage with certain input equipment.On the other hand, this software program of all or part also can be present in ROM (read-only memory) or the similar memory storage, and such device does not need this software program at first to be written into by input media.Those possessing an ordinary skill in the pertinent arts are appreciated that this software program or its some part can be loaded into system storage or cache memory or the combination of the two by processor by existing manner, are beneficial to carry out and carry out grab sample.
In one embodiment, software is stored in the computer server, and this computer server is connected with use terminal, input equipment or output device by data line, radiolink or network system, realizes sharing of data.
The present technique field is generally known, and network system is included in the hardware and software that is electrically connected in computing machine or the device.For example network system can comprise the equipment on the medium basis of internet, 10/1000 Ethernet, the 802.11x of electric electronic engineering association, electric electronic engineering association 1394, xDSL, bluetooth, LAN (Local Area Network), WLAN (wireless local area network), GSP, CDMA, 3G, PACS or any other ANSI Recognized Standards.
Utilize substance quantitative analysis method of the present invention to go for the analysis of all liquid state or gaseous material, have wide range of applications.Avoided seeking for some particular matters the trouble of suitable chromatographic analysis device, also having avoided is the trouble of the special mount scheme of the coupling design of two chromatographic columns.
Embodiment one:
Measured matter comprises A, B, four kinds of gaseous material compositions of C, D, and wherein, A is carrier gas, do not participate in reaction, and flow is constant; B and C are reacting gas; D is a reaction product.When analyzing measured matter with mass spectrometer, the ion A that A produced
aMeasured value be characteristic peak, the ion D that D produced
aMeasured value be characteristic peak.
Suppose D
01Be the concentration of A in the measured matter, D
02Be the concentration of D in the measured matter, the concentration ratio of A and D is in the measured matter
, the fluctuation range of R is 2.5-7.5.
The first step is got gaseous material A and D and is mixed two parts of demarcation of formation materials with 5: 1 ratio and 3: 1 ratio respectively.
Second step, analyze described two parts with mass spectrometer and demarcate material, obtain two groups of ion A
aMeasured value and ion D
aMeasured value.
The 3rd step is according to gaseous material A and the concentration of D, described two groups of ion A in described two parts of demarcation materials
aMeasured value and ion D
aMeasured value and following equation one carry out linear regression and calculate coefficient k and λ,
Equation one:
In the aforesaid equation one, D
1The concentration of material composition A in the material, D are demarcated in expression
2The concentration of material composition D in the material, I are demarcated in expression
1The measured value of the ion A a of material, I are demarcated in expression
2The measured value of the ion Da of material is demarcated in expression.
The 4th step, analyze measured matter with mass spectrometer, obtain the ion A of measured matter
aMeasured value and ion D
aMeasured value.
The 5th step is the D in the described equation one of the concentration substitution of gaseous material A
1, the ion A of the measured matter that obtains by the 4th step
aThe described equation one of measured value substitution in I
1, the ion D of the measured matter that obtains by the 4th step
aMeasured value substitution equation one in I
2, calculate the concentration of gaseous material D.
Embodiment two:
Measured matter comprises A, B, four kinds of gaseous material compositions of C, D, and wherein, A is carrier gas, is helium, do not participate in reaction, and flow is constant; B and C are reacting gas; D is a reaction product, is acetic acid (CH3COOH).When analyzing measured matter with mass spectrometer, the measured value of the He ion that A produced is a characteristic peak, and the measured value of the CH3COOH ion that D produced is a characteristic peak.
Suppose D
01Be the concentration of A in the measured matter, D
02Be the concentration of D in the measured matter, the concentration ratio of A and D is in the measured matter
, the fluctuation range of R is 2.5-7.5.
Because acetic acid is liquid at normal temperatures, utilize saturated vapor pressure can obtain the fixing demarcation material of acetate concentration.Saturated vapor pressure is relevant with temperature.Suppose in temperature T
1The saturated vapor pressure of following acetic acid is P
1, need P according to 5: 1 the ratio preparation helium and the potpourri of gaseous state acetic acid
1The helium of 5 pressure (is rationally thought the equation of gas state in lower pressure scope basic symbols, concentration ratio equals intrinsic standoff ratio substantially), because the saturated vapor pressure of acetic acid is very low, be beneficial to sample introduction in order to increase the pressure of demarcating material, need to add other gases (such as hydrogen), make the pressure of demarcating material reach satisfactory value.For example, P
1100 pressure is satisfactory force value, and so, the pressure of demarcating acetic acid in the material is P
1, the pressure of helium is P
15, the pressure of hydrogen is P
194.
The first step, material is demarcated in preparation.Can adopt the bubbling method to realize the mixing (require flow comparatively slow, more easily reach balance, otherwise may be forbidden) of gaseous state acetic acid, helium and hydrogen.Please join Fig. 2, it is P that helium source of the gas 11 provides pressure through pressure and flow controller (PFC) 12
15 helium, it is P that hydrogen source gas 13 provides pressure through pressure and flow controller 14
194 hydrogen, fill liquid acetic acid in the airtight container 15, described helium and hydrogen mix the back through fluid distributor 16 and enter under the liquid level of airtight container 15 by conveyance conduit 161, helium in airtight container 15 internal cavities, hydrogen and gaseous state acetic acid mixed gaseous material are the demarcation material, enter mass spectrometer 17 by conveyance conduit 171 and analyze.Utilize identical method preparation helium and acetic acid ratio to be 3: 1 demarcation material and to carry out mass spectrophotometry again.
Second step, analyze described two kinds with mass spectrometer and demarcate material, obtain the measured value of helium ion and the measured value of acetic acid ion.
The 3rd step, according to the concentration of the two parts of helium of demarcating materials and acetic acid, mass spectrometer the described two parts helium ion measured values of demarcating materials and acetic acid ion measured value and following equation one are carried out linear regression and calculate coefficient k and λ,
Equation one:
In the above equation one, D
1The concentration of He in the material, D are demarcated in expression
2The concentration of acetic acid in the material, I are demarcated in expression
1The measured value of material He ion, I are demarcated in expression
2The measured value of material acetic acid ion is demarcated in expression.
The 4th step, analyze measured matter with mass spectrometer, obtain the measured value of helium ion of measured matter and the measured value of acetic acid ion.
The 5th step is the D in the described equation one of the concentration substitution of helium in the measured matter
1, the I in the described equation one of the measured value substitution of the helium ion of measured matter
1, the I in the measured value substitution equation one of the acetic acid ion of measured matter
2, calculate the concentration of gaseous state acetic acid in the measured matter.
Claims (16)
1. a quantitative test comprises the method for the gaseous material sample of first material composition and second material composition, and wherein, second material composition is a corrosive substance, said method comprising the steps of:
Preparation N part comprises the demarcation sample of first material composition and second material composition, and wherein N is the natural number greater than 1, and described N part is demarcated the concentration ratio difference of first material composition of sample to second material composition;
Analyze described N part with mass spectrometer and demarcate sample, obtain to demarcate corresponding N relevant first material composition of group of sample and the measured value of second material composition with described N part;
Comprise the tested sample of first material composition and second material composition with mass spectrometer analysis one, obtain corresponding to relevant its first material composition that is comprised of this tested sample and the measured value of second material composition;
Obtain the concentration of first material composition in the tested sample;
Utilize the concentration of first material composition in the described tested sample, the measured value of relevant first material composition of described N group and second material composition, and the concentration that calculates second material composition in the tested sample corresponding to the measured value of relevant its first material composition that is comprised of this tested sample and second material composition.
2. the method for claim 1, it is characterized in that, described method also comprises utilizes described N part to demarcate first material composition and the concentration of second material composition and the measured value of described N relevant first material composition of group and second material composition in the sample, set up the linear relationship of the second material composition concentration and the measured value of the first material composition concentration, relevant first material composition and second material composition, wherein, the concentration of second material composition in the described tested sample is to calculate according to the concentration of first material composition in this linear relationship and the described measured matter to get.
3. the method for claim 1 is characterized in that, the concentration of first material composition is known in the described tested sample.
4. the method for claim 1, it is characterized in that, wherein, first material composition and second material composition will produce first ion and second ion respectively in mass spectrometer, the measured value of relevant first material composition of N group and second material composition comprises the first ion measured value and the second ion measured value.
5. method as claimed in claim 4 is characterized in that, it is characteristic peak that mass spectrometer is analyzed the measured matter ion measured value of winning.
6. method as claimed in claim 4 is characterized in that, it is characteristic peak that mass spectrometer is analyzed the measured matter gained second ion measured value.
7. the method for claim 1 is characterized in that, wherein, described second material composition is an organic acid.
8. an on-line quantitative analysis comprises the method for the gaseous material stream of first material composition and second material composition, and wherein, second material composition is a corrosive substance, said method comprising the steps of:
Preparation N part comprises the demarcation sample of first material composition and second material composition, and wherein N is the natural number greater than 1, and described N part is demarcated the concentration ratio difference of first material composition of sample to second material composition;
Analyze described N part with mass spectrometer and demarcate sample, obtain to demarcate corresponding N relevant first material composition of group of sample and the measured value of second material composition with described N part;
From described gaseous material stream, gather one first tested sample;
Analyze described first tested sample with described mass spectrometer, obtain corresponding to relevant its first material composition that is comprised of this first tested sample and the measured value of second material composition;
Obtain the concentration of first material composition in described first tested sample;
Utilize the concentration of first material composition in described first tested sample, the measured value of relevant first material composition of described N group and second material composition, and the concentration that calculates second material composition in this first tested sample corresponding to the measured value of relevant its first material composition that is comprised of this first tested sample and second material composition.
9. method as claimed in claim 8, it is characterized in that, described method also comprises utilizes described N part to demarcate first material composition and the concentration of second material composition and the measured value of described N relevant first material composition of group and second material composition in the sample, set up the linear relationship of the second material composition concentration and the measured value of the first material composition concentration, relevant first material composition and second material composition, wherein, the concentration of second material composition in the described tested sample is to calculate according to the concentration of first material composition in this linear relationship and the described measured matter to get.
10. method as claimed in claim 8 is characterized in that, the concentration of first material composition is known and roughly keeps constant in the described tested sample.
11. method as claimed in claim 8, it is characterized in that, wherein, first material composition and second material composition can produce first ion and second ion in mass spectrometer, and the measured value of relevant first material composition of N group and second material composition comprises the first ion measured value and the second ion measured value.
12. method as claimed in claim 11 is characterized in that, it is characteristic peak that mass spectrometer is analyzed the measured matter ion measured value of winning.
13. method as claimed in claim 11 is characterized in that, it is characteristic peak that mass spectrometer is analyzed the measured matter gained second ion measured value.
14. method as claimed in claim 8 is characterized in that, wherein, described second material composition is an organic acid.
15. method as claimed in claim 14 is characterized in that, wherein, described gaseous material stream is the product of synthetic carbon two oxygenatedchemicalss of synthetic gas.
16. method as claimed in claim 8 is characterized in that, wherein, described first material composition is an inert gas.
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| CNA200710307532XA CN101210913A (en) | 2006-12-30 | 2007-12-29 | Substance quantitative analysis method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101769901B (en) * | 2008-12-31 | 2012-07-04 | 北京联合大学生物化学工程学院 | Liquid phase chromatography data processing system based on FPGA |
| CN109358095A (en) * | 2018-11-06 | 2019-02-19 | 中广核研究院有限公司 | A kind of method for quantitative measuring and system of mixed gas each component gas concentration |
| CN113945530A (en) * | 2021-10-19 | 2022-01-18 | 中国计量科学研究院 | Gas concentration detection method and mass spectrometer |
-
2007
- 2007-12-29 CN CNA200710307532XA patent/CN101210913A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101769901B (en) * | 2008-12-31 | 2012-07-04 | 北京联合大学生物化学工程学院 | Liquid phase chromatography data processing system based on FPGA |
| CN109358095A (en) * | 2018-11-06 | 2019-02-19 | 中广核研究院有限公司 | A kind of method for quantitative measuring and system of mixed gas each component gas concentration |
| CN113945530A (en) * | 2021-10-19 | 2022-01-18 | 中国计量科学研究院 | Gas concentration detection method and mass spectrometer |
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