CN101205180A - Process for preparing ferrous succinate - Google Patents
Process for preparing ferrous succinate Download PDFInfo
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- CN101205180A CN101205180A CN 200610165390 CN200610165390A CN101205180A CN 101205180 A CN101205180 A CN 101205180A CN 200610165390 CN200610165390 CN 200610165390 CN 200610165390 A CN200610165390 A CN 200610165390A CN 101205180 A CN101205180 A CN 101205180A
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- ferrous
- oxidation inhibitor
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Abstract
The invention relates to a preparation process for iron supply medicine, the ferrous succinate (Formula I compounds). The ferrous succinate is generated by using the sodium succinate hexahydrate and the iron sulfate septhydrate as the raw materials and is prepared by adding an appropriate amount of the anti-oxide agents in the process of the reaction.
Description
Technical field
The present invention relates to a kind of preparation method who mends iron medicament ferrous succinate.
Background technology
Iron is one of human body important element, participates in the synthetic of oxyphorase, is transmitting oxygen and is participating in playing an important role in the human body Metabolic activity.Iron is the main moiety of oxyphorase and myohaemoglobin, and oxyphorase is the main carrier of oxygen in the red corpuscle.The patient of iron deficiency anemia is also many, is one of at present the most general and relevant with nutrition in the world disease.
Ferrous succinate is the same with ferrous sulfate, also belongs to the ferrous iron preparation, is characterized in the iron-holder height, and is rapid-action, makes good use of, and side effect is less, has been widely used in clinical.But because the unstable of ferrous iron in the aqueous solution, very easily be oxidized to ferric iron, cause in the product ferric iron content too high.So in actual production process,, carry out protective reaction more, make production cost improve, and produce wayward for the ferric content of the control methods of filling the nitrogen deoxygenation that adopt.Therefore it is a kind of can the stably manufactured ferrous succinate imperative to develop, and to vast iron deficiency patient's a blessing, also will bring huge economic benefit and good social effect.
Summary of the invention
The technical problem to be solved in the present invention provides a kind of stable ferrous succinate production technique.
The invention provides a kind of preparation technology of ferrous succinate, its structural formula is as follows:
It is characterized by:
A) deionized water, six hydration Soduxins, oxidation inhibitor are added in the reactor, the heated and stirred dissolving, gradation adds ferrous sulfate;
B) stirring reaction 3～4 hours at a certain temperature;
C) suction filtration, filter cake are used the deionized water and the organic solvent washing of equality of temperature respectively, and vacuum-drying gets the target compound ferrous succinate.
The present invention further provides preparation I compound and get the preparation method, wherein oxidation inhibitor can be selected xitix, S-WAT for use, and sodium bisulfite is preferentially selected sodium bisulfite for use.
The present invention further provides preparation I compound and get the preparation method, the oxidation inhibitor consumption that wherein prevents the ferrous ion oxidation is 1: 0.01～0.05 of a ferrous sulfate raw material consumption, and preferentially selecting ratio for use is 1: 0.02.
The present invention further provides preparation I compound and get the preparation method, wherein the cleaning solvent of Xuan Zeing is a water-soluble solvent, as ethanol, methyl alcohol, acetone.Be preferably acetone.
The present invention further provides preparation I compound and get the preparation method, wherein Fan Ying temperature condition be 60 ℃ to reflux temperature, preferentially select 80 ℃～90 ℃.
The present invention is owing to add oxidation inhibitor in reaction process, avoided the oxidation of ferrous ion in the reaction process, in last handling process, the organic solvent of adding and water immiscible phase dewaters, overcome the phenomenon that product is excessive owing to water content in drying process, the unstable product quality that oxidation causes may take place, greatly improved the quality of product, multiple batches of product ferric iron content is all less than 0.5%, and ferrous content reaches 35%.
Specific embodiment
Following embodiment is to describe in detail the present invention, and unrestricted the present invention.
Embodiment 1:
In reactor, add 30L deionized water, six hydration Soduxin 13.5kg, sodium bisulfite 0.26kg, heated and stirred dissolving, gradation adds ferrous sulfate 13.2kg, in about 4 hours of 80 ℃ of reactions, be cooled to 40 ℃, filter, filter cake extremely shows the sulfate ion reaction with the deionized water wash of equality of temperature earlier, washs with small amount of acetone again, 80 ℃ of dryings of vacuum make ferrous succinate 15.5kg, and yield is 90%.
Embodiment 2:
In reactor, add 30L deionized water, six hydration Soduxin 13.5kg, sodium bisulfite 0.28kg, heated and stirred dissolving, gradation adds ferrous sulfate 13.2kg, in about 3 hours of 90 ℃ of reactions, be cooled to 40 ℃, filter, filter cake extremely shows the sulfate ion reaction with the deionized water wash of equality of temperature earlier, washs with small amount of acetone again, 80 ℃ of dryings of vacuum make ferrous succinate 15.3kg, and yield is 89%.
Claims (5)
1. preparation technology who mends iron medicine ferrous succinate, its structural formula is as follows:
It is characterized by:
A) deionized water, six hydration Soduxins, oxidation inhibitor are added in the reactor, the heated and stirred dissolving, gradation adds ferrous sulfate;
B) stirring reaction 3～4 hours at a certain temperature;
C) suction filtration, filter cake are used the deionized water and the organic solvent washing of equality of temperature respectively, and vacuum-drying gets the target compound ferrous succinate.
2. preparation technology as claimed in claim 1 is characterized in that oxidation inhibitor can select xitix, S-WAT for use, and sodium bisulfite is preferentially selected sodium bisulfite for use.
3. preparation technology as claimed in claim 1 is characterized in that the oxidation inhibitor consumption that prevents the ferrous ion oxidation has certain limit, and its ratio is 1: 0.01～0.05 of a ferrous sulfate raw material consumption, and preferentially selecting ratio for use is 1: 0.02.
4. preparation technology as claimed in claim 1 is characterized in that the cleaning solvent of selecting is a water-soluble solvent, as ethanol, methyl alcohol, acetone.Be preferably acetone.
5. preparation technology as claimed in claim 1, the temperature condition that it is characterized in that chemical reaction be 60 ℃ to reflux temperature, preferentially select 80 ℃～90 ℃.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610165390 CN101205180A (en) | 2006-12-19 | 2006-12-19 | Process for preparing ferrous succinate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610165390 CN101205180A (en) | 2006-12-19 | 2006-12-19 | Process for preparing ferrous succinate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101205180A true CN101205180A (en) | 2008-06-25 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200610165390 Pending CN101205180A (en) | 2006-12-19 | 2006-12-19 | Process for preparing ferrous succinate |
Country Status (1)
| Country | Link |
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| CN (1) | CN101205180A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115141096A (en) * | 2022-05-16 | 2022-10-04 | 江苏中天药业有限公司 | Ferrous succinate tetrahydrate crystal form, preparation method thereof, raw material composition containing crystal form and application thereof |
-
2006
- 2006-12-19 CN CN 200610165390 patent/CN101205180A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115141096A (en) * | 2022-05-16 | 2022-10-04 | 江苏中天药业有限公司 | Ferrous succinate tetrahydrate crystal form, preparation method thereof, raw material composition containing crystal form and application thereof |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20080625 |