CN101163523B - 含有交联聚合物-过氧化物的牙齿增白组合物 - Google Patents
含有交联聚合物-过氧化物的牙齿增白组合物 Download PDFInfo
- Publication number
- CN101163523B CN101163523B CN200580048803.3A CN200580048803A CN101163523B CN 101163523 B CN101163523 B CN 101163523B CN 200580048803 A CN200580048803 A CN 200580048803A CN 101163523 B CN101163523 B CN 101163523B
- Authority
- CN
- China
- Prior art keywords
- care composition
- oral care
- polymer
- silicone
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 143
- 230000002087 whitening effect Effects 0.000 title claims abstract description 17
- -1 peroxide compound Chemical class 0.000 claims abstract description 87
- 150000002978 peroxides Chemical class 0.000 claims abstract description 50
- 239000000178 monomer Substances 0.000 claims abstract description 44
- 239000000463 material Substances 0.000 claims abstract description 22
- 229920000193 polymethacrylate Polymers 0.000 claims abstract description 11
- 229920006037 cross link polymer Polymers 0.000 claims abstract description 9
- 229920000058 polyacrylate Polymers 0.000 claims abstract description 7
- 229920000642 polymer Polymers 0.000 claims description 37
- 229920001296 polysiloxane Polymers 0.000 claims description 24
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 23
- 239000003795 chemical substances by application Substances 0.000 claims description 19
- 210000000214 mouth Anatomy 0.000 claims description 18
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 16
- 238000006116 polymerization reaction Methods 0.000 claims description 14
- 229920001223 polyethylene glycol Polymers 0.000 claims description 13
- 239000011230 binding agent Substances 0.000 claims description 12
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 claims description 11
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 11
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 11
- LVHBHZANLOWSRM-UHFFFAOYSA-N itaconic acid Chemical compound OC(=O)CC(=C)C(O)=O LVHBHZANLOWSRM-UHFFFAOYSA-N 0.000 claims description 10
- 239000000377 silicon dioxide Substances 0.000 claims description 10
- 239000013464 silicone adhesive Substances 0.000 claims description 10
- 229920002050 silicone resin Polymers 0.000 claims description 10
- 229920001477 hydrophilic polymer Polymers 0.000 claims description 9
- 235000012239 silicon dioxide Nutrition 0.000 claims description 9
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 8
- 239000002202 Polyethylene glycol Substances 0.000 claims description 8
- 239000004094 surface-active agent Substances 0.000 claims description 8
- 239000012530 fluid Substances 0.000 claims description 7
- 229920005573 silicon-containing polymer Polymers 0.000 claims description 7
- 229920001400 block copolymer Polymers 0.000 claims description 6
- 239000003086 colorant Substances 0.000 claims description 6
- 239000002480 mineral oil Substances 0.000 claims description 6
- 235000010446 mineral oil Nutrition 0.000 claims description 6
- 239000001294 propane Substances 0.000 claims description 6
- 238000001179 sorption measurement Methods 0.000 claims description 6
- 235000013599 spices Nutrition 0.000 claims description 6
- 239000012190 activator Substances 0.000 claims description 5
- 229920002379 silicone rubber Polymers 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 239000013543 active substance Substances 0.000 claims description 4
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 4
- 229940099259 vaseline Drugs 0.000 claims description 4
- 229920000831 ionic polymer Polymers 0.000 claims description 3
- 239000011148 porous material Substances 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- FBCQUCJYYPMKRO-UHFFFAOYSA-N prop-2-enyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCC=C FBCQUCJYYPMKRO-UHFFFAOYSA-N 0.000 claims description 3
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 2
- DBCAQXHNJOFNGC-UHFFFAOYSA-N 4-bromo-1,1,1-trifluorobutane Chemical compound FC(F)(F)CCCBr DBCAQXHNJOFNGC-UHFFFAOYSA-N 0.000 claims 1
- STVZJERGLQHEKB-UHFFFAOYSA-N ethylene glycol dimethacrylate Substances CC(=C)C(=O)OCCOC(=O)C(C)=C STVZJERGLQHEKB-UHFFFAOYSA-N 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 23
- 239000002131 composite material Substances 0.000 abstract description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 27
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 22
- 229920002554 vinyl polymer Polymers 0.000 description 15
- 150000002148 esters Chemical class 0.000 description 13
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 12
- 229920001577 copolymer Polymers 0.000 description 12
- 239000007788 liquid Substances 0.000 description 12
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 11
- 239000003082 abrasive agent Substances 0.000 description 9
- 150000001875 compounds Chemical class 0.000 description 9
- 230000000694 effects Effects 0.000 description 9
- 239000002253 acid Substances 0.000 description 8
- IISBACLAFKSPIT-UHFFFAOYSA-N bisphenol A Chemical compound C=1C=C(O)C=CC=1C(C)(C)C1=CC=C(O)C=C1 IISBACLAFKSPIT-UHFFFAOYSA-N 0.000 description 8
- MYRTYDVEIRVNKP-UHFFFAOYSA-N 1,2-Divinylbenzene Chemical compound C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 description 7
- 239000004820 Pressure-sensitive adhesive Substances 0.000 description 7
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Natural products OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 7
- 235000011187 glycerol Nutrition 0.000 description 7
- 229920000620 organic polymer Polymers 0.000 description 7
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 7
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 6
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 6
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 6
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 235000012000 cholesterol Nutrition 0.000 description 6
- 229940063557 methacrylate Drugs 0.000 description 6
- SCPYDCQAZCOKTP-UHFFFAOYSA-N silanol Chemical compound [SiH3]O SCPYDCQAZCOKTP-UHFFFAOYSA-N 0.000 description 6
- 235000002639 sodium chloride Nutrition 0.000 description 6
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 5
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 5
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 5
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 5
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 5
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 5
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 5
- 239000007844 bleaching agent Substances 0.000 description 5
- 229910052799 carbon Inorganic materials 0.000 description 5
- 125000004432 carbon atom Chemical group C* 0.000 description 5
- 239000003085 diluting agent Substances 0.000 description 5
- 239000006260 foam Substances 0.000 description 5
- 239000011976 maleic acid Substances 0.000 description 5
- 150000003839 salts Chemical class 0.000 description 5
- 239000000600 sorbitol Substances 0.000 description 5
- 235000010356 sorbitol Nutrition 0.000 description 5
- 239000000080 wetting agent Substances 0.000 description 5
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 4
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 4
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 description 4
- 229910019142 PO4 Inorganic materials 0.000 description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical class OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 4
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 4
- 229930006000 Sucrose Natural products 0.000 description 4
- 239000002585 base Substances 0.000 description 4
- 239000011324 bead Substances 0.000 description 4
- 229940106691 bisphenol a Drugs 0.000 description 4
- 238000005282 brightening Methods 0.000 description 4
- 239000004567 concrete Substances 0.000 description 4
- 230000002209 hydrophobic effect Effects 0.000 description 4
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 4
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 4
- 239000011859 microparticle Substances 0.000 description 4
- 229910052757 nitrogen Chemical group 0.000 description 4
- 239000003002 pH adjusting agent Substances 0.000 description 4
- 229940059574 pentaerithrityl Drugs 0.000 description 4
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 description 4
- 239000010452 phosphate Substances 0.000 description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 125000001424 substituent group Chemical group 0.000 description 4
- 239000005720 sucrose Substances 0.000 description 4
- 239000002562 thickening agent Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- HIXDQWDOVZUNNA-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-hydroxy-7-methoxychromen-4-one Chemical compound C=1C(OC)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=C(OC)C(OC)=C1 HIXDQWDOVZUNNA-UHFFFAOYSA-N 0.000 description 3
- JAHNSTQSQJOJLO-UHFFFAOYSA-N 2-(3-fluorophenyl)-1h-imidazole Chemical compound FC1=CC=CC(C=2NC=CN=2)=C1 JAHNSTQSQJOJLO-UHFFFAOYSA-N 0.000 description 3
- JKNCOURZONDCGV-UHFFFAOYSA-N 2-(dimethylamino)ethyl 2-methylprop-2-enoate Chemical compound CN(C)CCOC(=O)C(C)=C JKNCOURZONDCGV-UHFFFAOYSA-N 0.000 description 3
- 229940044192 2-hydroxyethyl methacrylate Drugs 0.000 description 3
- YYPNJNDODFVZLE-UHFFFAOYSA-N 3-methylbut-2-enoic acid Chemical compound CC(C)=CC(O)=O YYPNJNDODFVZLE-UHFFFAOYSA-N 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- PNEYBMLMFCGWSK-UHFFFAOYSA-N Alumina Chemical compound [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- QOSMNYMQXIVWKY-UHFFFAOYSA-N Propyl levulinate Chemical compound CCCOC(=O)CCC(C)=O QOSMNYMQXIVWKY-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 229920002125 Sokalan® Polymers 0.000 description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
- QYKIQEUNHZKYBP-UHFFFAOYSA-N Vinyl ether Chemical compound C=COC=C QYKIQEUNHZKYBP-UHFFFAOYSA-N 0.000 description 3
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 239000003513 alkali Substances 0.000 description 3
- 229910001413 alkali metal ion Inorganic materials 0.000 description 3
- 229910001420 alkaline earth metal ion Inorganic materials 0.000 description 3
- 125000000217 alkyl group Chemical group 0.000 description 3
- 150000001408 amides Chemical class 0.000 description 3
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 3
- 238000004061 bleaching Methods 0.000 description 3
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 3
- GTZCVFVGUGFEME-IWQZZHSRSA-N cis-aconitic acid Chemical compound OC(=O)C\C(C(O)=O)=C\C(O)=O GTZCVFVGUGFEME-IWQZZHSRSA-N 0.000 description 3
- 238000013270 controlled release Methods 0.000 description 3
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- 239000008103 glucose Substances 0.000 description 3
- 229920001600 hydrophobic polymer Polymers 0.000 description 3
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 3
- 239000003607 modifier Substances 0.000 description 3
- 239000002736 nonionic surfactant Substances 0.000 description 3
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 3
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 150000005846 sugar alcohols Polymers 0.000 description 3
- 238000011282 treatment Methods 0.000 description 3
- AQLJVWUFPCUVLO-UHFFFAOYSA-N urea hydrogen peroxide Chemical compound OO.NC(N)=O AQLJVWUFPCUVLO-UHFFFAOYSA-N 0.000 description 3
- KAKZBPTYRLMSJV-UHFFFAOYSA-N vinyl-ethylene Natural products C=CC=C KAKZBPTYRLMSJV-UHFFFAOYSA-N 0.000 description 3
- 239000000811 xylitol Substances 0.000 description 3
- 235000010447 xylitol Nutrition 0.000 description 3
- 229960002675 xylitol Drugs 0.000 description 3
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 3
- KJPRLNWUNMBNBZ-QPJJXVBHSA-N (E)-cinnamaldehyde Chemical compound O=C\C=C\C1=CC=CC=C1 KJPRLNWUNMBNBZ-QPJJXVBHSA-N 0.000 description 2
- WVAFEFUPWRPQSY-UHFFFAOYSA-N 1,2,3-tris(ethenyl)benzene Chemical compound C=CC1=CC=CC(C=C)=C1C=C WVAFEFUPWRPQSY-UHFFFAOYSA-N 0.000 description 2
- SERLAGPUMNYUCK-DCUALPFSSA-N 1-O-alpha-D-glucopyranosyl-D-mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-DCUALPFSSA-N 0.000 description 2
- JLIDVCMBCGBIEY-UHFFFAOYSA-N 1-penten-3-one Chemical compound CCC(=O)C=C JLIDVCMBCGBIEY-UHFFFAOYSA-N 0.000 description 2
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 2
- RWXMAAYKJDQVTF-UHFFFAOYSA-N 2-(2-hydroxyethoxy)ethyl prop-2-enoate Chemical compound OCCOCCOC(=O)C=C RWXMAAYKJDQVTF-UHFFFAOYSA-N 0.000 description 2
- XEZCCHVCBAZAQD-UHFFFAOYSA-N 2-(aziridin-1-yl)ethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCN1CC1 XEZCCHVCBAZAQD-UHFFFAOYSA-N 0.000 description 2
- 125000000022 2-aminoethyl group Chemical group [H]C([*])([H])C([H])([H])N([H])[H] 0.000 description 2
- GLVYLTSKTCWWJR-UHFFFAOYSA-N 2-carbonoperoxoylbenzoic acid Chemical class OOC(=O)C1=CC=CC=C1C(O)=O GLVYLTSKTCWWJR-UHFFFAOYSA-N 0.000 description 2
- ZGHFDIIVVIFNPS-UHFFFAOYSA-N 3-Methyl-3-buten-2-one Chemical compound CC(=C)C(C)=O ZGHFDIIVVIFNPS-UHFFFAOYSA-N 0.000 description 2
- VTLKLYJOUVMHIY-UHFFFAOYSA-N 3-ethenylpenta-1,3-diene;urea Chemical compound NC(N)=O.CC=C(C=C)C=C VTLKLYJOUVMHIY-UHFFFAOYSA-N 0.000 description 2
- GNSFRPWPOGYVLO-UHFFFAOYSA-N 3-hydroxypropyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCCO GNSFRPWPOGYVLO-UHFFFAOYSA-N 0.000 description 2
- ATVJXMYDOSMEPO-UHFFFAOYSA-N 3-prop-2-enoxyprop-1-ene Chemical compound C=CCOCC=C ATVJXMYDOSMEPO-UHFFFAOYSA-N 0.000 description 2
- ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 description 2
- SOGAXMICEFXMKE-UHFFFAOYSA-N Butylmethacrylate Chemical compound CCCCOC(=O)C(C)=C SOGAXMICEFXMKE-UHFFFAOYSA-N 0.000 description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 2
- SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 2
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 2
- 239000005977 Ethylene Substances 0.000 description 2
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 2
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 2
- 229930195725 Mannitol Natural products 0.000 description 2
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 description 2
- 239000004384 Neotame Substances 0.000 description 2
- 241001597008 Nomeidae Species 0.000 description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- ZJCCRDAZUWHFQH-UHFFFAOYSA-N Trimethylolpropane Chemical compound CCC(CO)(CO)CO ZJCCRDAZUWHFQH-UHFFFAOYSA-N 0.000 description 2
- AXMVYSVVTMKQSL-UHFFFAOYSA-N UNPD142122 Natural products OC1=CC=C(C=CC=O)C=C1O AXMVYSVVTMKQSL-UHFFFAOYSA-N 0.000 description 2
- 240000008042 Zea mays Species 0.000 description 2
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 2
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 229910021529 ammonia Inorganic materials 0.000 description 2
- 239000001099 ammonium carbonate Substances 0.000 description 2
- 239000002280 amphoteric surfactant Substances 0.000 description 2
- 125000000129 anionic group Chemical group 0.000 description 2
- 239000003945 anionic surfactant Substances 0.000 description 2
- MWPLVEDNUUSJAV-UHFFFAOYSA-N anthracene Chemical compound C1=CC=CC2=CC3=CC=CC=C3C=C21 MWPLVEDNUUSJAV-UHFFFAOYSA-N 0.000 description 2
- 125000004429 atom Chemical group 0.000 description 2
- HUMNYLRZRPPJDN-UHFFFAOYSA-N benzaldehyde Chemical compound O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 description 2
- 150000001555 benzenes Chemical class 0.000 description 2
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 2
- WERYXYBDKMZEQL-UHFFFAOYSA-N butane-1,4-diol Chemical compound OCCCCO WERYXYBDKMZEQL-UHFFFAOYSA-N 0.000 description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 description 2
- LHJQIRIGXXHNLA-UHFFFAOYSA-N calcium peroxide Chemical compound [Ca+2].[O-][O-] LHJQIRIGXXHNLA-UHFFFAOYSA-N 0.000 description 2
- 229940043256 calcium pyrophosphate Drugs 0.000 description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 description 2
- 239000000679 carrageenan Substances 0.000 description 2
- 229920001525 carrageenan Polymers 0.000 description 2
- 229940113118 carrageenan Drugs 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- KJPRLNWUNMBNBZ-UHFFFAOYSA-N cinnamic aldehyde Natural products O=CC=CC1=CC=CC=C1 KJPRLNWUNMBNBZ-UHFFFAOYSA-N 0.000 description 2
- 229940117916 cinnamic aldehyde Drugs 0.000 description 2
- 239000004927 clay Substances 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 235000005822 corn Nutrition 0.000 description 2
- 238000004132 cross linking Methods 0.000 description 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 2
- 208000002925 dental caries Diseases 0.000 description 2
- 239000004205 dimethyl polysiloxane Substances 0.000 description 2
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 description 2
- 235000011180 diphosphates Nutrition 0.000 description 2
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 238000007046 ethoxylation reaction Methods 0.000 description 2
- 125000004494 ethyl ester group Chemical group 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 229960002737 fructose Drugs 0.000 description 2
- 239000001530 fumaric acid Substances 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 125000000524 functional group Chemical group 0.000 description 2
- PYGSKMBEVAICCR-UHFFFAOYSA-N hexa-1,5-diene Chemical group C=CCCC=C PYGSKMBEVAICCR-UHFFFAOYSA-N 0.000 description 2
- 229920001519 homopolymer Polymers 0.000 description 2
- 229910010272 inorganic material Inorganic materials 0.000 description 2
- 239000011147 inorganic material Substances 0.000 description 2
- 239000000905 isomalt Substances 0.000 description 2
- 235000010439 isomalt Nutrition 0.000 description 2
- HPIGCVXMBGOWTF-UHFFFAOYSA-N isomaltol Natural products CC(=O)C=1OC=CC=1O HPIGCVXMBGOWTF-UHFFFAOYSA-N 0.000 description 2
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 description 2
- 239000000594 mannitol Substances 0.000 description 2
- 235000010355 mannitol Nutrition 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- FQPSGWSUVKBHSU-UHFFFAOYSA-N methacrylamide Chemical compound CC(=C)C(N)=O FQPSGWSUVKBHSU-UHFFFAOYSA-N 0.000 description 2
- 150000004702 methyl esters Chemical class 0.000 description 2
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- HLIAVLHNDJUHFG-HOTGVXAUSA-N neotame Chemical compound CC(C)(C)CCN[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 HLIAVLHNDJUHFG-HOTGVXAUSA-N 0.000 description 2
- 235000019412 neotame Nutrition 0.000 description 2
- 108010070257 neotame Proteins 0.000 description 2
- 235000013615 non-nutritive sweetener Nutrition 0.000 description 2
- ZVVSSOQAYNYNPP-UHFFFAOYSA-N olaflur Chemical compound F.F.CCCCCCCCCCCCCCCCCCN(CCO)CCCN(CCO)CCO ZVVSSOQAYNYNPP-UHFFFAOYSA-N 0.000 description 2
- 229960001245 olaflur Drugs 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000003973 paint Substances 0.000 description 2
- UCUUFSAXZMGPGH-UHFFFAOYSA-N penta-1,4-dien-3-one Chemical compound C=CC(=O)C=C UCUUFSAXZMGPGH-UHFFFAOYSA-N 0.000 description 2
- DBSDMAPJGHBWAL-UHFFFAOYSA-N penta-1,4-dien-3-ylbenzene Chemical compound C=CC(C=C)C1=CC=CC=C1 DBSDMAPJGHBWAL-UHFFFAOYSA-N 0.000 description 2
- 150000004965 peroxy acids Chemical class 0.000 description 2
- JRKICGRDRMAZLK-UHFFFAOYSA-L peroxydisulfate Chemical compound [O-]S(=O)(=O)OOS([O-])(=O)=O JRKICGRDRMAZLK-UHFFFAOYSA-L 0.000 description 2
- 235000011007 phosphoric acid Nutrition 0.000 description 2
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 2
- 150000004291 polyenes Chemical class 0.000 description 2
- 229920002635 polyurethane Polymers 0.000 description 2
- 239000004814 polyurethane Substances 0.000 description 2
- NROKBHXJSPEDAR-UHFFFAOYSA-M potassium fluoride Chemical compound [F-].[K+] NROKBHXJSPEDAR-UHFFFAOYSA-M 0.000 description 2
- XXQBEVHPUKOQEO-UHFFFAOYSA-N potassium superoxide Chemical compound [K+].[K+].[O-][O-] XXQBEVHPUKOQEO-UHFFFAOYSA-N 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 230000003449 preventive effect Effects 0.000 description 2
- QTECDUFMBMSHKR-UHFFFAOYSA-N prop-2-enyl prop-2-enoate Chemical compound C=CCOC(=O)C=C QTECDUFMBMSHKR-UHFFFAOYSA-N 0.000 description 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 239000012744 reinforcing agent Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- GHMLBKRAJCXXBS-UHFFFAOYSA-N resorcinol Chemical compound OC1=CC=CC(O)=C1 GHMLBKRAJCXXBS-UHFFFAOYSA-N 0.000 description 2
- 210000003296 saliva Anatomy 0.000 description 2
- 238000005201 scrubbing Methods 0.000 description 2
- DCKVNWZUADLDEH-UHFFFAOYSA-N sec-butyl acetate Chemical compound CCC(C)OC(C)=O DCKVNWZUADLDEH-UHFFFAOYSA-N 0.000 description 2
- 239000004945 silicone rubber Substances 0.000 description 2
- 229910000029 sodium carbonate Inorganic materials 0.000 description 2
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 2
- 239000006188 syrup Substances 0.000 description 2
- 235000020357 syrup Nutrition 0.000 description 2
- 239000011975 tartaric acid Substances 0.000 description 2
- 235000002906 tartaric acid Nutrition 0.000 description 2
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 2
- 239000000606 toothpaste Substances 0.000 description 2
- 229940034610 toothpaste Drugs 0.000 description 2
- RUVINXPYWBROJD-ONEGZZNKSA-N trans-anethole Chemical compound COC1=CC=C(\C=C\C)C=C1 RUVINXPYWBROJD-ONEGZZNKSA-N 0.000 description 2
- KQTIIICEAUMSDG-UHFFFAOYSA-N tricarballylic acid Chemical compound OC(=O)CC(C(O)=O)CC(O)=O KQTIIICEAUMSDG-UHFFFAOYSA-N 0.000 description 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 2
- UIYCHXAGWOYNNA-UHFFFAOYSA-N vinyl sulfide Chemical compound C=CSC=C UIYCHXAGWOYNNA-UHFFFAOYSA-N 0.000 description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- AOFUBOWZWQFQJU-SNOJBQEQSA-N (2r,3s,4s,5r)-2,5-bis(hydroxymethyl)oxolane-2,3,4-triol;(2s,3r,4s,5s,6r)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O.OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O AOFUBOWZWQFQJU-SNOJBQEQSA-N 0.000 description 1
- 239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 description 1
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 1
- CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Natural products CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 description 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 1
- GNEPLYVYORHREW-UHFFFAOYSA-N 1,1,3,3,6-pentamethyl-7-nitro-2h-inden-5-amine Chemical compound CC1=C(N)C=C2C(C)(C)CC(C)(C)C2=C1[N+]([O-])=O GNEPLYVYORHREW-UHFFFAOYSA-N 0.000 description 1
- ZWUBFMWIQJSEQS-UHFFFAOYSA-N 1,1-bis(ethenyl)cyclohexane Chemical compound C=CC1(C=C)CCCCC1 ZWUBFMWIQJSEQS-UHFFFAOYSA-N 0.000 description 1
- QLLUAUADIMPKIH-UHFFFAOYSA-N 1,2-bis(ethenyl)naphthalene Chemical compound C1=CC=CC2=C(C=C)C(C=C)=CC=C21 QLLUAUADIMPKIH-UHFFFAOYSA-N 0.000 description 1
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 1
- OZCMOJQQLBXBKI-UHFFFAOYSA-N 1-ethenoxy-2-methylpropane Chemical compound CC(C)COC=C OZCMOJQQLBXBKI-UHFFFAOYSA-N 0.000 description 1
- OVGRCEFMXPHEBL-UHFFFAOYSA-N 1-ethenoxypropane Chemical compound CCCOC=C OVGRCEFMXPHEBL-UHFFFAOYSA-N 0.000 description 1
- IYSVFZBXZVPIFA-UHFFFAOYSA-N 1-ethenyl-4-(4-ethenylphenyl)benzene Chemical group C1=CC(C=C)=CC=C1C1=CC=C(C=C)C=C1 IYSVFZBXZVPIFA-UHFFFAOYSA-N 0.000 description 1
- PKJBRKTYYNRVSN-UHFFFAOYSA-N 10-(aminomethyl)-9,10-dihydroanthracene-1,2-diol Chemical compound OC1=CC=C2C(CN)C3=CC=CC=C3CC2=C1O PKJBRKTYYNRVSN-UHFFFAOYSA-N 0.000 description 1
- FCMUPMSEVHVOSE-UHFFFAOYSA-N 2,3-bis(ethenyl)pyridine Chemical compound C=CC1=CC=CN=C1C=C FCMUPMSEVHVOSE-UHFFFAOYSA-N 0.000 description 1
- OXJIPDWNJZFBRI-UHFFFAOYSA-N 2,3-dihydroxybutanedioic acid 3-methylbut-2-enoic acid Chemical compound CC(=CC(=O)O)C.C(C(O)C(O)C(=O)O)(=O)O OXJIPDWNJZFBRI-UHFFFAOYSA-N 0.000 description 1
- VSDZUDQPXOUABS-UHFFFAOYSA-N 2,3-dihydroxypropyl 3-methylbut-2-enoate Chemical compound CC(=CC(=O)OCC(O)CO)C VSDZUDQPXOUABS-UHFFFAOYSA-N 0.000 description 1
- FXNDIJDIPNCZQJ-UHFFFAOYSA-N 2,4,4-trimethylpent-1-ene Chemical group CC(=C)CC(C)(C)C FXNDIJDIPNCZQJ-UHFFFAOYSA-N 0.000 description 1
- JTTIOYHBNXDJOD-UHFFFAOYSA-N 2,4,6-triaminopyrimidine Chemical compound NC1=CC(N)=NC(N)=N1 JTTIOYHBNXDJOD-UHFFFAOYSA-N 0.000 description 1
- ZKLMKZINKNMVKA-UHFFFAOYSA-N 2-(2-hydroxypropoxy)propan-1-ol;2-methylprop-2-enoic acid Chemical compound CC(=C)C(O)=O.CC(O)COC(C)CO ZKLMKZINKNMVKA-UHFFFAOYSA-N 0.000 description 1
- YATYDCQGPUOZGZ-UHFFFAOYSA-N 2-(2-hydroxypropoxy)propan-1-ol;prop-2-enoic acid Chemical compound OC(=O)C=C.CC(O)COC(C)CO YATYDCQGPUOZGZ-UHFFFAOYSA-N 0.000 description 1
- JECYNCQXXKQDJN-UHFFFAOYSA-N 2-(2-methylhexan-2-yloxymethyl)oxirane Chemical compound CCCCC(C)(C)OCC1CO1 JECYNCQXXKQDJN-UHFFFAOYSA-N 0.000 description 1
- SJIXRGNQPBQWMK-UHFFFAOYSA-N 2-(diethylamino)ethyl 2-methylprop-2-enoate Chemical compound CCN(CC)CCOC(=O)C(C)=C SJIXRGNQPBQWMK-UHFFFAOYSA-N 0.000 description 1
- DPBJAVGHACCNRL-UHFFFAOYSA-N 2-(dimethylamino)ethyl prop-2-enoate Chemical compound CN(C)CCOC(=O)C=C DPBJAVGHACCNRL-UHFFFAOYSA-N 0.000 description 1
- HWSSEYVMGDIFMH-UHFFFAOYSA-N 2-[2-[2-(2-methylprop-2-enoyloxy)ethoxy]ethoxy]ethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCOCCOCCOC(=O)C(C)=C HWSSEYVMGDIFMH-UHFFFAOYSA-N 0.000 description 1
- TXBCBTDQIULDIA-UHFFFAOYSA-N 2-[[3-hydroxy-2,2-bis(hydroxymethyl)propoxy]methyl]-2-(hydroxymethyl)propane-1,3-diol Chemical compound OCC(CO)(CO)COCC(CO)(CO)CO TXBCBTDQIULDIA-UHFFFAOYSA-N 0.000 description 1
- UXFQFBNBSPQBJW-UHFFFAOYSA-N 2-amino-2-methylpropane-1,3-diol Chemical compound OCC(N)(C)CO UXFQFBNBSPQBJW-UHFFFAOYSA-N 0.000 description 1
- UGIJCMNGQCUTPI-UHFFFAOYSA-N 2-aminoethyl prop-2-enoate Chemical compound NCCOC(=O)C=C UGIJCMNGQCUTPI-UHFFFAOYSA-N 0.000 description 1
- JWCDUUFOAZFFMX-UHFFFAOYSA-N 2-ethenoxy-n,n-dimethylethanamine Chemical class CN(C)CCOC=C JWCDUUFOAZFFMX-UHFFFAOYSA-N 0.000 description 1
- CEYHHQSTMVVZQP-UHFFFAOYSA-N 2-ethenoxyethanamine Chemical class NCCOC=C CEYHHQSTMVVZQP-UHFFFAOYSA-N 0.000 description 1
- RCORSHSFJCXHTF-UHFFFAOYSA-N 2-ethenyl-1,3-dioxan-5-ol Chemical compound OC1COC(C=C)OC1 RCORSHSFJCXHTF-UHFFFAOYSA-N 0.000 description 1
- CBRXCJKZQIQWEG-UHFFFAOYSA-N 2-ethenylsulfanyl-n,n-dimethylethanamine Chemical compound CN(C)CCSC=C CBRXCJKZQIQWEG-UHFFFAOYSA-N 0.000 description 1
- OXQUUXVRVJBDMA-UHFFFAOYSA-N 2-ethoxyprop-2-enamide Chemical compound CCOC(=C)C(N)=O OXQUUXVRVJBDMA-UHFFFAOYSA-N 0.000 description 1
- OMIGHNLMNHATMP-UHFFFAOYSA-N 2-hydroxyethyl prop-2-enoate Chemical compound OCCOC(=O)C=C OMIGHNLMNHATMP-UHFFFAOYSA-N 0.000 description 1
- GWZMWHWAWHPNHN-UHFFFAOYSA-N 2-hydroxypropyl prop-2-enoate Chemical compound CC(O)COC(=O)C=C GWZMWHWAWHPNHN-UHFFFAOYSA-N 0.000 description 1
- GILMNGUTRWPWSY-UHFFFAOYSA-N 2-hydroxypropyl prop-2-enoate;2-methylprop-2-enoic acid Chemical compound CC(=C)C(O)=O.CC(O)COC(=O)C=C GILMNGUTRWPWSY-UHFFFAOYSA-N 0.000 description 1
- YXYJVFYWCLAXHO-UHFFFAOYSA-N 2-methoxyethyl 2-methylprop-2-enoate Chemical compound COCCOC(=O)C(C)=C YXYJVFYWCLAXHO-UHFFFAOYSA-N 0.000 description 1
- XEWQXJJJOIKGTP-UHFFFAOYSA-N 2-methylprop-2-enoic acid;octadecanoic acid Chemical compound CC(=C)C(O)=O.CCCCCCCCCCCCCCCCCC(O)=O XEWQXJJJOIKGTP-UHFFFAOYSA-N 0.000 description 1
- MUZDXNQOSGWMJJ-UHFFFAOYSA-N 2-methylprop-2-enoic acid;prop-2-enoic acid Chemical compound OC(=O)C=C.CC(=C)C(O)=O MUZDXNQOSGWMJJ-UHFFFAOYSA-N 0.000 description 1
- DXCJRBVVRJYMQT-UHFFFAOYSA-N 2-methylprop-2-enoic acid;pyrrolidin-2-one Chemical compound CC(=C)C(O)=O.O=C1CCCN1 DXCJRBVVRJYMQT-UHFFFAOYSA-N 0.000 description 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 1
- KGIGUEBEKRSTEW-UHFFFAOYSA-N 2-vinylpyridine Chemical compound C=CC1=CC=CC=N1 KGIGUEBEKRSTEW-UHFFFAOYSA-N 0.000 description 1
- DPZYLEIWHTWHCU-UHFFFAOYSA-N 3-ethenylpyridine Chemical compound C=CC1=CC=CN=C1 DPZYLEIWHTWHCU-UHFFFAOYSA-N 0.000 description 1
- IZUVGRMMRWJVKU-UHFFFAOYSA-N 3-ethoxycarbonylbut-3-enoic acid Chemical compound CCOC(=O)C(=C)CC(O)=O IZUVGRMMRWJVKU-UHFFFAOYSA-N 0.000 description 1
- XSLBWJPPWWFTQY-UHFFFAOYSA-N 3-hydroperoxypropane-1,2-diol Chemical compound OCC(O)COO XSLBWJPPWWFTQY-UHFFFAOYSA-N 0.000 description 1
- QZPSOSOOLFHYRR-UHFFFAOYSA-N 3-hydroxypropyl prop-2-enoate Chemical compound OCCCOC(=O)C=C QZPSOSOOLFHYRR-UHFFFAOYSA-N 0.000 description 1
- AMULJSVDIHMAOX-UHFFFAOYSA-N 3-hydroxypropyl prop-2-enoate;prop-2-enoic acid Chemical compound OC(=O)C=C.OCCCOC(=O)C=C AMULJSVDIHMAOX-UHFFFAOYSA-N 0.000 description 1
- ULRILTNCHCCGBA-UHFFFAOYSA-N 4,4-bis(ethenyl)piperidine Chemical class C(=C)C1(CCNCC1)C=C ULRILTNCHCCGBA-UHFFFAOYSA-N 0.000 description 1
- LBSXSAXOLABXMF-UHFFFAOYSA-N 4-Vinylaniline Chemical group NC1=CC=C(C=C)C=C1 LBSXSAXOLABXMF-UHFFFAOYSA-N 0.000 description 1
- DDFHBQSCUXNBSA-UHFFFAOYSA-N 5-(5-carboxythiophen-2-yl)thiophene-2-carboxylic acid Chemical compound S1C(C(=O)O)=CC=C1C1=CC=C(C(O)=O)S1 DDFHBQSCUXNBSA-UHFFFAOYSA-N 0.000 description 1
- YOQXWFAPUCIKIH-UHFFFAOYSA-N 5-ethenyl-2-ethylpyridine Chemical compound CCC1=CC=C(C=C)C=N1 YOQXWFAPUCIKIH-UHFFFAOYSA-N 0.000 description 1
- SGMGVYDSPXFBMU-UHFFFAOYSA-N 5-ethenyl-2-methylaniline Chemical group CC1=CC=C(C=C)C=C1N SGMGVYDSPXFBMU-UHFFFAOYSA-N 0.000 description 1
- IQAGXMNEUYBTLG-UHFFFAOYSA-N 5-hydroxy-2-methylpent-2-enamide Chemical compound NC(=O)C(C)=CCCO IQAGXMNEUYBTLG-UHFFFAOYSA-N 0.000 description 1
- COCLLEMEIJQBAG-UHFFFAOYSA-N 8-methylnonyl 2-methylprop-2-enoate Chemical compound CC(C)CCCCCCCOC(=O)C(C)=C COCLLEMEIJQBAG-UHFFFAOYSA-N 0.000 description 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- 229910000013 Ammonium bicarbonate Inorganic materials 0.000 description 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- 108010011485 Aspartame Proteins 0.000 description 1
- 241000416162 Astragalus gummifer Species 0.000 description 1
- 239000004342 Benzoyl peroxide Substances 0.000 description 1
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical group C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical class OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 1
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 1
- VGSLORJPNYOXGN-VOTSOKGWSA-N C(=C)OC(\C(\C)=C\C(=O)OC=C)=O Chemical compound C(=C)OC(\C(\C)=C\C(=O)OC=C)=O VGSLORJPNYOXGN-VOTSOKGWSA-N 0.000 description 1
- RVHUKDSPPBTUSC-UHFFFAOYSA-N C(=O)O.[S] Chemical compound C(=O)O.[S] RVHUKDSPPBTUSC-UHFFFAOYSA-N 0.000 description 1
- ZJONKBBJBLFPIS-UHFFFAOYSA-N C(C=C)(=O)OCC(CCCN(C)C)O.C(C(=C)C)(=O)O Chemical compound C(C=C)(=O)OCC(CCCN(C)C)O.C(C(=C)C)(=O)O ZJONKBBJBLFPIS-UHFFFAOYSA-N 0.000 description 1
- SZURUOYHRAJRSY-UHFFFAOYSA-N C(C=C)(=O)OCC(CCCN(C)C)O.C(C=C)(=O)O Chemical compound C(C=C)(=O)OCC(CCCN(C)C)O.C(C=C)(=O)O SZURUOYHRAJRSY-UHFFFAOYSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 239000004343 Calcium peroxide Substances 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 241001147468 Chondrus ocellatus Species 0.000 description 1
- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 description 1
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 1
- 244000060011 Cocos nucifera Species 0.000 description 1
- 235000013162 Cocos nucifera Nutrition 0.000 description 1
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 description 1
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
- HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- 208000006558 Dental Calculus Diseases 0.000 description 1
- 208000002064 Dental Plaque Diseases 0.000 description 1
- 229940090898 Desensitizer Drugs 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004641 Diallyl-phthalate Substances 0.000 description 1
- HECLRDQVFMWTQS-UHFFFAOYSA-N Dicyclopentadiene Chemical compound C1C2C3CC=CC3C1C=C2 HECLRDQVFMWTQS-UHFFFAOYSA-N 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 239000004386 Erythritol Substances 0.000 description 1
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 1
- WEEGYLXZBRQIMU-UHFFFAOYSA-N Eucalyptol Chemical compound C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 description 1
- 241000628997 Flos Species 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 229920001908 Hydrogenated starch hydrolysate Polymers 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
- 229910001051 Magnalium Inorganic materials 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- SPAGIJMPHSUYSE-UHFFFAOYSA-N Magnesium peroxide Chemical compound [Mg+2].[O-][O-] SPAGIJMPHSUYSE-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- GSYWJWFOKRBGQB-UHFFFAOYSA-N N(=O)OC(C)CCCCCC.C(C(=C)C)(=O)O Chemical compound N(=O)OC(C)CCCCCC.C(C(=C)C)(=O)O GSYWJWFOKRBGQB-UHFFFAOYSA-N 0.000 description 1
- CNCOEDDPFOAUMB-UHFFFAOYSA-N N-Methylolacrylamide Chemical compound OCNC(=O)C=C CNCOEDDPFOAUMB-UHFFFAOYSA-N 0.000 description 1
- PVCJKHHOXFKFRP-UHFFFAOYSA-N N-acetylethanolamine Chemical class CC(=O)NCCO PVCJKHHOXFKFRP-UHFFFAOYSA-N 0.000 description 1
- YCZVNBQAIZENBU-UHFFFAOYSA-N NC(=O)N.C(=C)C=CC=C Chemical compound NC(=O)N.C(=C)C=CC=C YCZVNBQAIZENBU-UHFFFAOYSA-N 0.000 description 1
- 229920000305 Nylon 6,10 Polymers 0.000 description 1
- YDHVEJBUCSJGQT-UHFFFAOYSA-N OC(=O)C=C.OC(=O)C=C.OC(=O)C=C.OCCN(CCO)CCO Chemical compound OC(=O)C=C.OC(=O)C=C.OC(=O)C=C.OCCN(CCO)CCO YDHVEJBUCSJGQT-UHFFFAOYSA-N 0.000 description 1
- YDUHWMJLHNNZMR-UHFFFAOYSA-N OC(=O)C=C.OC(=O)C=C.OCCN(CCO)CCO Chemical compound OC(=O)C=C.OC(=O)C=C.OCCN(CCO)CCO YDUHWMJLHNNZMR-UHFFFAOYSA-N 0.000 description 1
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 description 1
- QLZHNIAADXEJJP-UHFFFAOYSA-N Phenylphosphonic acid Chemical compound OP(O)(=O)C1=CC=CC=C1 QLZHNIAADXEJJP-UHFFFAOYSA-N 0.000 description 1
- ATTZFSUZZUNHBP-UHFFFAOYSA-N Piperonyl sulfoxide Chemical compound CCCCCCCCS(=O)C(C)CC1=CC=C2OCOC2=C1 ATTZFSUZZUNHBP-UHFFFAOYSA-N 0.000 description 1
- 229920002260 Pluraflo® Polymers 0.000 description 1
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
- 108010009736 Protein Hydrolysates Proteins 0.000 description 1
- PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 description 1
- 229910004298 SiO 2 Inorganic materials 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical group [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 239000004141 Sodium laurylsulphate Substances 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- 239000004376 Sucralose Substances 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- LCXXNKZQVOXMEH-UHFFFAOYSA-N Tetrahydrofurfuryl methacrylate Chemical compound CC(=C)C(=O)OCC1CCCO1 LCXXNKZQVOXMEH-UHFFFAOYSA-N 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 239000005844 Thymol Substances 0.000 description 1
- 235000011941 Tilia x europaea Nutrition 0.000 description 1
- 208000004509 Tooth Discoloration Diseases 0.000 description 1
- 206010044032 Tooth discolouration Diseases 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 description 1
- IAXXETNIOYFMLW-COPLHBTASA-N [(1s,3s,4s)-4,7,7-trimethyl-3-bicyclo[2.2.1]heptanyl] 2-methylprop-2-enoate Chemical compound C1C[C@]2(C)[C@@H](OC(=O)C(=C)C)C[C@H]1C2(C)C IAXXETNIOYFMLW-COPLHBTASA-N 0.000 description 1
- QRSFFHRCBYCWBS-UHFFFAOYSA-N [O].[O] Chemical group [O].[O] QRSFFHRCBYCWBS-UHFFFAOYSA-N 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 229920006243 acrylic copolymer Polymers 0.000 description 1
- 125000003647 acryloyl group Chemical group O=C([*])C([H])=C([H])[H] 0.000 description 1
- ORILYTVJVMAKLC-UHFFFAOYSA-N adamantane Chemical compound C1C(C2)CC3CC1CC2C3 ORILYTVJVMAKLC-UHFFFAOYSA-N 0.000 description 1
- 229910001573 adamantine Inorganic materials 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 description 1
- 150000008051 alkyl sulfates Chemical class 0.000 description 1
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- UZFLPKAIBPNNCA-BQYQJAHWSA-N alpha-ionone Chemical compound CC(=O)\C=C\C1C(C)=CCCC1(C)C UZFLPKAIBPNNCA-BQYQJAHWSA-N 0.000 description 1
- UZFLPKAIBPNNCA-UHFFFAOYSA-N alpha-ionone Natural products CC(=O)C=CC1C(C)=CCCC1(C)C UZFLPKAIBPNNCA-UHFFFAOYSA-N 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 235000012538 ammonium bicarbonate Nutrition 0.000 description 1
- 235000012501 ammonium carbonate Nutrition 0.000 description 1
- 239000000908 ammonium hydroxide Substances 0.000 description 1
- 229940011037 anethole Drugs 0.000 description 1
- IYRHBDVSMINOTQ-UHFFFAOYSA-N aniline;ethene Chemical group C=C.NC1=CC=CC=C1 IYRHBDVSMINOTQ-UHFFFAOYSA-N 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000002690 anti-lithiasic effect Effects 0.000 description 1
- 230000002882 anti-plaque Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 1
- 150000001491 aromatic compounds Chemical class 0.000 description 1
- 239000000605 aspartame Substances 0.000 description 1
- 235000010357 aspartame Nutrition 0.000 description 1
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 1
- 229960003438 aspartame Drugs 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- UHHXUPJJDHEMGX-UHFFFAOYSA-K azanium;manganese(3+);phosphonato phosphate Chemical compound [NH4+].[Mn+3].[O-]P([O-])(=O)OP([O-])([O-])=O UHHXUPJJDHEMGX-UHFFFAOYSA-K 0.000 description 1
- IRERQBUNZFJFGC-UHFFFAOYSA-L azure blue Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Al+3].[Al+3].[Al+3].[Al+3].[Al+3].[Al+3].[S-]S[S-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-] IRERQBUNZFJFGC-UHFFFAOYSA-L 0.000 description 1
- 229910052788 barium Inorganic materials 0.000 description 1
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 description 1
- ZJRXSAYFZMGQFP-UHFFFAOYSA-N barium peroxide Chemical compound [Ba+2].[O-][O-] ZJRXSAYFZMGQFP-UHFFFAOYSA-N 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 235000019400 benzoyl peroxide Nutrition 0.000 description 1
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 1
- ORZGJQJXBLFGRP-AATRIKPKSA-N bis(ethenyl) (e)-but-2-enedioate Chemical compound C=COC(=O)\C=C\C(=O)OC=C ORZGJQJXBLFGRP-AATRIKPKSA-N 0.000 description 1
- VGSLORJPNYOXGN-SREVYHEPSA-N bis(ethenyl) (z)-2-methylbut-2-enedioate Chemical compound C=COC(=O)C(/C)=C\C(=O)OC=C VGSLORJPNYOXGN-SREVYHEPSA-N 0.000 description 1
- ORZGJQJXBLFGRP-WAYWQWQTSA-N bis(ethenyl) (z)-but-2-enedioate Chemical compound C=COC(=O)\C=C/C(=O)OC=C ORZGJQJXBLFGRP-WAYWQWQTSA-N 0.000 description 1
- BFHRUCFCIXWADD-UHFFFAOYSA-N bis(ethenyl) 2,3-dihydroxybutanedioate Chemical compound C=COC(=O)C(O)C(O)C(=O)OC=C BFHRUCFCIXWADD-UHFFFAOYSA-N 0.000 description 1
- AJCHRUXIDGEWDK-UHFFFAOYSA-N bis(ethenyl) butanedioate Chemical compound C=COC(=O)CCC(=O)OC=C AJCHRUXIDGEWDK-UHFFFAOYSA-N 0.000 description 1
- CHQUIOWVSPIVJB-UHFFFAOYSA-N bis(ethenyl) decanedioate Chemical compound C=COC(=O)CCCCCCCCC(=O)OC=C CHQUIOWVSPIVJB-UHFFFAOYSA-N 0.000 description 1
- IHTWATXYZJSPOM-UHFFFAOYSA-N bis(ethenyl) oxalate Chemical compound C=COC(=O)C(=O)OC=C IHTWATXYZJSPOM-UHFFFAOYSA-N 0.000 description 1
- AALXAILNCMAJFZ-UHFFFAOYSA-N bis(ethenyl) propanedioate Chemical compound C=COC(=O)CC(=O)OC=C AALXAILNCMAJFZ-UHFFFAOYSA-N 0.000 description 1
- ZPOLOEWJWXZUSP-AATRIKPKSA-N bis(prop-2-enyl) (e)-but-2-enedioate Chemical compound C=CCOC(=O)\C=C\C(=O)OCC=C ZPOLOEWJWXZUSP-AATRIKPKSA-N 0.000 description 1
- ZPOLOEWJWXZUSP-WAYWQWQTSA-N bis(prop-2-enyl) (z)-but-2-enedioate Chemical compound C=CCOC(=O)\C=C/C(=O)OCC=C ZPOLOEWJWXZUSP-WAYWQWQTSA-N 0.000 description 1
- QUDWYFHPNIMBFC-UHFFFAOYSA-N bis(prop-2-enyl) benzene-1,2-dicarboxylate Chemical compound C=CCOC(=O)C1=CC=CC=C1C(=O)OCC=C QUDWYFHPNIMBFC-UHFFFAOYSA-N 0.000 description 1
- JKJWYKGYGWOAHT-UHFFFAOYSA-N bis(prop-2-enyl) carbonate Chemical group C=CCOC(=O)OCC=C JKJWYKGYGWOAHT-UHFFFAOYSA-N 0.000 description 1
- FPODCVUTIPDRTE-UHFFFAOYSA-N bis(prop-2-enyl) hexanedioate Chemical compound C=CCOC(=O)CCCCC(=O)OCC=C FPODCVUTIPDRTE-UHFFFAOYSA-N 0.000 description 1
- BKXRKRANFLFTFU-UHFFFAOYSA-N bis(prop-2-enyl) oxalate Chemical compound C=CCOC(=O)C(=O)OCC=C BKXRKRANFLFTFU-UHFFFAOYSA-N 0.000 description 1
- 229940073609 bismuth oxychloride Drugs 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- MPMBRWOOISTHJV-UHFFFAOYSA-N but-1-enylbenzene Chemical compound CCC=CC1=CC=CC=C1 MPMBRWOOISTHJV-UHFFFAOYSA-N 0.000 description 1
- 239000001273 butane Substances 0.000 description 1
- FUSUHKVFWTUUBE-UHFFFAOYSA-N buten-2-one Chemical compound CC(=O)C=C FUSUHKVFWTUUBE-UHFFFAOYSA-N 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 1
- ROPDWRCJTIRLTR-UHFFFAOYSA-L calcium metaphosphate Chemical compound [Ca+2].[O-]P(=O)=O.[O-]P(=O)=O ROPDWRCJTIRLTR-UHFFFAOYSA-L 0.000 description 1
- 235000019402 calcium peroxide Nutrition 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229940025250 camphora Drugs 0.000 description 1
- 239000010238 camphora Substances 0.000 description 1
- 229960001631 carbomer Drugs 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 239000007766 cera flava Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000005660 chlorination reaction Methods 0.000 description 1
- YACLQRRMGMJLJV-UHFFFAOYSA-N chloroprene Chemical compound ClC(=C)C=C YACLQRRMGMJLJV-UHFFFAOYSA-N 0.000 description 1
- 229960005233 cineole Drugs 0.000 description 1
- 229930016911 cinnamic acid Natural products 0.000 description 1
- 235000013985 cinnamic acid Nutrition 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical group CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 description 1
- 229940073507 cocamidopropyl betaine Drugs 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 239000008119 colloidal silica Substances 0.000 description 1
- 238000004737 colorimetric analysis Methods 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 239000007859 condensation product Substances 0.000 description 1
- 238000006482 condensation reaction Methods 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- PDXRQENMIVHKPI-UHFFFAOYSA-N cyclohexane-1,1-diol Chemical compound OC1(O)CCCCC1 PDXRQENMIVHKPI-UHFFFAOYSA-N 0.000 description 1
- OIWOHHBRDFKZNC-UHFFFAOYSA-N cyclohexyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OC1CCCCC1 OIWOHHBRDFKZNC-UHFFFAOYSA-N 0.000 description 1
- 238000005202 decontamination Methods 0.000 description 1
- 230000003588 decontaminative effect Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 229960000935 dehydrated alcohol Drugs 0.000 description 1
- 210000003298 dental enamel Anatomy 0.000 description 1
- 239000004053 dental implant Substances 0.000 description 1
- 239000005548 dental material Substances 0.000 description 1
- 239000000551 dentifrice Substances 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 239000012933 diacyl peroxide Substances 0.000 description 1
- 235000019821 dicalcium diphosphate Nutrition 0.000 description 1
- QGGZBXOADPVUPN-UHFFFAOYSA-N dihydrochalcone Chemical compound C=1C=CC=CC=1C(=O)CCC1=CC=CC=C1 QGGZBXOADPVUPN-UHFFFAOYSA-N 0.000 description 1
- PXLWOFBAEVGBOA-UHFFFAOYSA-N dihydrochalcone Natural products OC1C(O)C(O)C(CO)OC1C1=C(O)C=CC(C(=O)CC(O)C=2C=CC(O)=CC=2)=C1O PXLWOFBAEVGBOA-UHFFFAOYSA-N 0.000 description 1
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 1
- 239000002526 disodium citrate Substances 0.000 description 1
- 235000019262 disodium citrate Nutrition 0.000 description 1
- CEYULKASIQJZGP-UHFFFAOYSA-L disodium;2-(carboxymethyl)-2-hydroxybutanedioate Chemical compound [Na+].[Na+].[O-]C(=O)CC(O)(C(=O)O)CC([O-])=O CEYULKASIQJZGP-UHFFFAOYSA-L 0.000 description 1
- VTIIJXUACCWYHX-UHFFFAOYSA-L disodium;carboxylatooxy carbonate Chemical compound [Na+].[Na+].[O-]C(=O)OOC([O-])=O VTIIJXUACCWYHX-UHFFFAOYSA-L 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 125000004119 disulfanediyl group Chemical group *SS* 0.000 description 1
- AFOSIXZFDONLBT-UHFFFAOYSA-N divinyl sulfone Chemical compound C=CS(=O)(=O)C=C AFOSIXZFDONLBT-UHFFFAOYSA-N 0.000 description 1
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 239000000806 elastomer Substances 0.000 description 1
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 1
- 235000019414 erythritol Nutrition 0.000 description 1
- 229940009714 erythritol Drugs 0.000 description 1
- 238000005530 etching Methods 0.000 description 1
- 150000002168 ethanoic acid esters Chemical class 0.000 description 1
- BXOUVIIITJXIKB-UHFFFAOYSA-N ethene;styrene Chemical compound C=C.C=CC1=CC=CC=C1 BXOUVIIITJXIKB-UHFFFAOYSA-N 0.000 description 1
- FJKIXWOMBXYWOQ-UHFFFAOYSA-N ethenoxyethane Chemical compound CCOC=C FJKIXWOMBXYWOQ-UHFFFAOYSA-N 0.000 description 1
- FYUWIEKAVLOHSE-UHFFFAOYSA-N ethenyl acetate;1-ethenylpyrrolidin-2-one Chemical compound CC(=O)OC=C.C=CN1CCCC1=O FYUWIEKAVLOHSE-UHFFFAOYSA-N 0.000 description 1
- MEGHWIAOTJPCHQ-UHFFFAOYSA-N ethenyl butanoate Chemical compound CCCC(=O)OC=C MEGHWIAOTJPCHQ-UHFFFAOYSA-N 0.000 description 1
- GLVVKKSPKXTQRB-UHFFFAOYSA-N ethenyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OC=C GLVVKKSPKXTQRB-UHFFFAOYSA-N 0.000 description 1
- BLCTWBJQROOONQ-UHFFFAOYSA-N ethenyl prop-2-enoate Chemical compound C=COC(=O)C=C BLCTWBJQROOONQ-UHFFFAOYSA-N 0.000 description 1
- 125000005448 ethoxyethyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])C([H])([H])* 0.000 description 1
- SUPCQIBBMFXVTL-UHFFFAOYSA-N ethyl 2-methylprop-2-enoate Chemical compound CCOC(=O)C(C)=C SUPCQIBBMFXVTL-UHFFFAOYSA-N 0.000 description 1
- UHESRSKEBRADOO-UHFFFAOYSA-N ethyl carbamate;prop-2-enoic acid Chemical compound OC(=O)C=C.CCOC(N)=O UHESRSKEBRADOO-UHFFFAOYSA-N 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- SFNALCNOMXIBKG-UHFFFAOYSA-N ethylene glycol monododecyl ether Chemical compound CCCCCCCCCCCCOCCO SFNALCNOMXIBKG-UHFFFAOYSA-N 0.000 description 1
- 229960005082 etohexadiol Drugs 0.000 description 1
- 229940044949 eucalyptus oil Drugs 0.000 description 1
- 239000010642 eucalyptus oil Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- SKSIDEOZXDVBGN-UHFFFAOYSA-N fluoro dihydrogen phosphate Chemical compound OP(O)(=O)OF SKSIDEOZXDVBGN-UHFFFAOYSA-N 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- UKWVGRNWMAFAOV-UHFFFAOYSA-N furan-2,5-dione;2-[2-(2-hydroxyethoxy)ethoxy]ethanol Chemical compound O=C1OC(=O)C=C1.OCCOCCOCCO UKWVGRNWMAFAOV-UHFFFAOYSA-N 0.000 description 1
- 229930182830 galactose Natural products 0.000 description 1
- 229960003082 galactose Drugs 0.000 description 1
- 229940050410 gluconate Drugs 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 229960005150 glycerol Drugs 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 125000005842 heteroatom Chemical group 0.000 description 1
- 150000002391 heterocyclic compounds Chemical class 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- 125000004836 hexamethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[*:1] 0.000 description 1
- XXMIOPMDWAUFGU-UHFFFAOYSA-N hexane-1,6-diol Chemical compound OCCCCCCO XXMIOPMDWAUFGU-UHFFFAOYSA-N 0.000 description 1
- 235000019534 high fructose corn syrup Nutrition 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 150000002432 hydroperoxides Chemical class 0.000 description 1
- 150000001261 hydroxy acids Chemical group 0.000 description 1
- 229940071826 hydroxyethyl cellulose Drugs 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 150000002460 imidazoles Chemical class 0.000 description 1
- 150000003949 imides Chemical class 0.000 description 1
- 150000002466 imines Chemical class 0.000 description 1
- 238000007373 indentation Methods 0.000 description 1
- 229910052738 indium Inorganic materials 0.000 description 1
- APFVFJFRJDLVQX-UHFFFAOYSA-N indium atom Chemical compound [In] APFVFJFRJDLVQX-UHFFFAOYSA-N 0.000 description 1
- 239000003999 initiator Substances 0.000 description 1
- DCYOBGZUOMKFPA-UHFFFAOYSA-N iron(2+);iron(3+);octadecacyanide Chemical compound [Fe+2].[Fe+2].[Fe+2].[Fe+3].[Fe+3].[Fe+3].[Fe+3].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-] DCYOBGZUOMKFPA-UHFFFAOYSA-N 0.000 description 1
- WTFXARWRTYJXII-UHFFFAOYSA-N iron(2+);iron(3+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[O-2].[Fe+2].[Fe+3].[Fe+3] WTFXARWRTYJXII-UHFFFAOYSA-N 0.000 description 1
- SZVJSHCCFOBDDC-UHFFFAOYSA-N iron(II,III) oxide Inorganic materials O=[Fe]O[Fe]O[Fe]=O SZVJSHCCFOBDDC-UHFFFAOYSA-N 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 229940119545 isobornyl methacrylate Drugs 0.000 description 1
- LDHQCZJRKDOVOX-IHWYPQMZSA-N isocrotonic acid Chemical compound C\C=C/C(O)=O LDHQCZJRKDOVOX-IHWYPQMZSA-N 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- 150000003951 lactams Chemical class 0.000 description 1
- 150000003903 lactic acid esters Chemical class 0.000 description 1
- 229960004194 lidocaine Drugs 0.000 description 1
- 239000004571 lime Substances 0.000 description 1
- 229930007744 linalool Natural products 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- HPGPEWYJWRWDTP-UHFFFAOYSA-N lithium peroxide Chemical compound [Li+].[Li+].[O-][O-] HPGPEWYJWRWDTP-UHFFFAOYSA-N 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 229960003511 macrogol Drugs 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- HCWCAKKEBCNQJP-UHFFFAOYSA-N magnesium orthosilicate Chemical compound [Mg+2].[Mg+2].[O-][Si]([O-])([O-])[O-] HCWCAKKEBCNQJP-UHFFFAOYSA-N 0.000 description 1
- 239000000391 magnesium silicate Substances 0.000 description 1
- 229910052919 magnesium silicate Inorganic materials 0.000 description 1
- 235000019792 magnesium silicate Nutrition 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- HNEGQIOMVPPMNR-NSCUHMNNSA-N mesaconic acid Chemical compound OC(=O)C(/C)=C/C(O)=O HNEGQIOMVPPMNR-NSCUHMNNSA-N 0.000 description 1
- 125000005641 methacryl group Chemical group 0.000 description 1
- OJURWUUOVGOHJZ-UHFFFAOYSA-N methyl 2-[(2-acetyloxyphenyl)methyl-[2-[(2-acetyloxyphenyl)methyl-(2-methoxy-2-oxoethyl)amino]ethyl]amino]acetate Chemical compound C=1C=CC=C(OC(C)=O)C=1CN(CC(=O)OC)CCN(CC(=O)OC)CC1=CC=CC=C1OC(C)=O OJURWUUOVGOHJZ-UHFFFAOYSA-N 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 description 1
- XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical compound COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- HNEGQIOMVPPMNR-UHFFFAOYSA-N methylfumaric acid Natural products OC(=O)C(C)=CC(O)=O HNEGQIOMVPPMNR-UHFFFAOYSA-N 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- HWPKGOGLCKPRLZ-UHFFFAOYSA-M monosodium citrate Chemical compound [Na+].OC(=O)CC(O)(C([O-])=O)CC(O)=O HWPKGOGLCKPRLZ-UHFFFAOYSA-M 0.000 description 1
- 239000002524 monosodium citrate Substances 0.000 description 1
- 235000018342 monosodium citrate Nutrition 0.000 description 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 1
- 235000019799 monosodium phosphate Nutrition 0.000 description 1
- ZIUHHBKFKCYYJD-UHFFFAOYSA-N n,n'-methylenebisacrylamide Chemical compound C=CC(=O)NCNC(=O)C=C ZIUHHBKFKCYYJD-UHFFFAOYSA-N 0.000 description 1
- DNTMQTKDNSEIFO-UHFFFAOYSA-N n-(hydroxymethyl)-2-methylprop-2-enamide Chemical compound CC(=C)C(=O)NCO DNTMQTKDNSEIFO-UHFFFAOYSA-N 0.000 description 1
- CXMXRPHRNRROMY-UHFFFAOYSA-N n-Decanedioic acid Natural products OC(=O)CCCCCCCCC(O)=O CXMXRPHRNRROMY-UHFFFAOYSA-N 0.000 description 1
- IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 description 1
- COYVWKMZTCAFHO-UHFFFAOYSA-N n-methyl-n-propan-2-ylprop-2-enamide Chemical compound CC(C)N(C)C(=O)C=C COYVWKMZTCAFHO-UHFFFAOYSA-N 0.000 description 1
- YPHQUSNPXDGUHL-UHFFFAOYSA-N n-methylprop-2-enamide Chemical compound CNC(=O)C=C YPHQUSNPXDGUHL-UHFFFAOYSA-N 0.000 description 1
- OFBQJSOFQDEBGM-UHFFFAOYSA-N n-pentane Natural products CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 1
- 229920001206 natural gum Polymers 0.000 description 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 239000011368 organic material Substances 0.000 description 1
- 150000001451 organic peroxides Chemical class 0.000 description 1
- 125000005375 organosiloxane group Chemical group 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- MPQXHAGKBWFSNV-UHFFFAOYSA-N oxidophosphanium Chemical class [PH3]=O MPQXHAGKBWFSNV-UHFFFAOYSA-N 0.000 description 1
- BWOROQSFKKODDR-UHFFFAOYSA-N oxobismuth;hydrochloride Chemical compound Cl.[Bi]=O BWOROQSFKKODDR-UHFFFAOYSA-N 0.000 description 1
- 125000006353 oxyethylene group Chemical group 0.000 description 1
- 239000006174 pH buffer Substances 0.000 description 1
- QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 description 1
- RUVINXPYWBROJD-UHFFFAOYSA-N para-methoxyphenyl Natural products COC1=CC=C(C=CC)C=C1 RUVINXPYWBROJD-UHFFFAOYSA-N 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 125000001151 peptidyl group Chemical group 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 125000005342 perphosphate group Chemical group 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- AZEQMGPWGQJEBN-UHFFFAOYSA-N phosphorous acid;prop-1-ene Chemical group CC=C.OP(O)O AZEQMGPWGQJEBN-UHFFFAOYSA-N 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229960000502 poloxamer Drugs 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 description 1
- 229920001515 polyalkylene glycol Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920000307 polymer substrate Polymers 0.000 description 1
- 229940045916 polymetaphosphate Drugs 0.000 description 1
- 229940051841 polyoxyethylene ether Drugs 0.000 description 1
- 229920000056 polyoxyethylene ether Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229920001290 polyvinyl ester Polymers 0.000 description 1
- 239000001253 polyvinylpolypyrrolidone Substances 0.000 description 1
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 description 1
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 239000011736 potassium bicarbonate Substances 0.000 description 1
- 235000015497 potassium bicarbonate Nutrition 0.000 description 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
- 239000011698 potassium fluoride Substances 0.000 description 1
- 235000003270 potassium fluoride Nutrition 0.000 description 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
- 229940069328 povidone Drugs 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- HJWLCRVIBGQPNF-UHFFFAOYSA-N prop-2-enylbenzene Chemical compound C=CCC1=CC=CC=C1 HJWLCRVIBGQPNF-UHFFFAOYSA-N 0.000 description 1
- 235000020095 red wine Nutrition 0.000 description 1
- 239000003507 refrigerant Substances 0.000 description 1
- 229940071089 sarcosinate Drugs 0.000 description 1
- 150000005619 secondary aliphatic amines Chemical class 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229940071207 sesquicarbonate Drugs 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 230000000391 smoking effect Effects 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 239000011775 sodium fluoride Substances 0.000 description 1
- 235000013024 sodium fluoride Nutrition 0.000 description 1
- GCLGEJMYGQKIIW-UHFFFAOYSA-H sodium hexametaphosphate Chemical compound [Na]OP1(=O)OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])O1 GCLGEJMYGQKIIW-UHFFFAOYSA-H 0.000 description 1
- 235000019982 sodium hexametaphosphate Nutrition 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 229940045872 sodium percarbonate Drugs 0.000 description 1
- PFUVRDFDKPNGAV-UHFFFAOYSA-N sodium peroxide Chemical compound [Na+].[Na+].[O-][O-] PFUVRDFDKPNGAV-UHFFFAOYSA-N 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- ZUFONQSOSYEWCN-UHFFFAOYSA-M sodium;2-(methylamino)acetate Chemical compound [Na+].CNCC([O-])=O ZUFONQSOSYEWCN-UHFFFAOYSA-M 0.000 description 1
- JHJUUEHSAZXEEO-UHFFFAOYSA-M sodium;4-dodecylbenzenesulfonate Chemical compound [Na+].CCCCCCCCCCCCC1=CC=C(S([O-])(=O)=O)C=C1 JHJUUEHSAZXEEO-UHFFFAOYSA-M 0.000 description 1
- MWNQXXOSWHCCOZ-UHFFFAOYSA-L sodium;oxido carbonate Chemical compound [Na+].[O-]OC([O-])=O MWNQXXOSWHCCOZ-UHFFFAOYSA-L 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 1
- 229960002799 stannous fluoride Drugs 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 235000019408 sucralose Nutrition 0.000 description 1
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 238000006277 sulfonation reaction Methods 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 229940104261 taurate Drugs 0.000 description 1
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- 125000001302 tertiary amino group Chemical group 0.000 description 1
- RWRDLPDLKQPQOW-UHFFFAOYSA-N tetrahydropyrrole Substances C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 description 1
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229960000790 thymol Drugs 0.000 description 1
- IUTCEZPPWBHGIX-UHFFFAOYSA-N tin(2+) Chemical compound [Sn+2] IUTCEZPPWBHGIX-UHFFFAOYSA-N 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 235000019505 tobacco product Nutrition 0.000 description 1
- 230000036367 tooth discoloration Effects 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- BJIOGJUNALELMI-ONEGZZNKSA-N trans-isoeugenol Chemical compound COC1=CC(\C=C\C)=CC=C1O BJIOGJUNALELMI-ONEGZZNKSA-N 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 229940113165 trimethylolpropane Drugs 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 229960000834 vinyl ether Drugs 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000003871 white petrolatum Substances 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
本发明在各个实施方案中提供包含过氧化物复合物和口腔可接受载体的牙齿增白组合物。过氧化物复合物包含过氧化合物和优选为微孔颗粒形式的多孔交联聚合物。过氧化合物可吸着到多孔交联聚合物上。多孔交联聚合物可包含选自聚丙烯酸酯、聚甲基丙烯酸酯、聚衣康酸酯和其混合物的聚合多不饱和单体。载体可以是非水载体,且可包含成膜材料。还提供了用所述牙齿增白组合物增白牙齿表面的方法。
Description
相关申请的交叉引用
本申请要求2004年12月30日提交的美国临时申请系列号60/640,656的优先权,该临时申请的内容通过引用结合到本文中。
发明背景
由于牙齿材料的吸收特性,牙齿有色斑、发黄或变色几乎是不可避免的。各种日常活动,例如吸烟或以其他方式口用烟制品,以及食用、咀嚼或饮用某些食物和饮料(特别是咖啡或茶和红酒),都会导致不合宜的牙齿表面色斑。色斑也可能由微生物活动产生,包括与牙菌斑有关的微生物活动。即使经常用牙刷和牙线清洁,经年的色原积累也会产生明显可见的牙齿变色。
专业的牙齿处理往往包括先进行牙齿表面制备如酸蚀刻,然后施加高度浓缩的漂白溶液(例如高达37%过氧化氢)和/或施加热或光。这些程序见效快,但费用高,往往需要到牙医那里几回。在许多情况下,在整个治疗过程中患者的嘴唇要不舒服地缩进,且患者要被限制坐在牙科椅上。
或者,可在家里使用漂白系统。这些系统在过去的十年里由于成本降低和方便性提高而得到极大的普及。可在消费零售店购得牙齿增白剂,且可边使用边进行其它个人事务或差事、放松和睡觉,这样就不会耗费时间和经常要去看牙医。
目前的家庭治疗方法包括磨料牙膏、能产生氧化物的牙膏、与牙托盘(dental tray)和增白条(whitening strip)一起使用的增白凝胶。这种技术的有效性取决于各种因素,包括色斑的类型和强度,漂白剂的类型、漂白剂做牙齿上的接触时间、组合物中可利用的漂白活性物质的数量、漂白剂渗入牙釉质的能力和消费者的依从性。有效性还取决于组合物中漂白活性物质的数量、活性物质在使用过程中的释放能力和活性物质在产品中的稳定性。但是,由于一种或多种涉及组合物和消费者依从性的因素的缺陷,许多这些治疗的有效性受到不利影响。
发明简述
本发明提供包含过氧化物复合物(peroxide composite)的口腔护理组合物,所述过氧化物复合物包含过氧化合物(peroxidecompound)和多孔交联聚合物。也可包括口腔可接受载体。
在各个实施方案中,聚合物包含选自聚丙烯酸酯、聚甲基丙烯酸酯、聚衣康酸酯和其混合物的聚合多不饱和单体。在一个实施方案中,载体包含成膜材料。还提供了用以增白牙齿表面的方法,所述方法包括施加安全和有效量的包含过氧化合物和多孔交联聚合物的过氧化物复合物。
发明详述
已发现,本发明的组合物和方法相比于本领域公知的口腔护理组合物可提供包括以下一种或多种的优点:增白功效提高,提供更高可利用浓度的漂白剂,在唾液存在下不用牙齿托盘就能粘附于牙齿,漂白剂缓释和/或控释。
本发明提供用以给予或施加到或用于人或其它动物对象的口腔护理组合物和方法。
本发明提供包含过氧化物复合物的组合物。过氧化物复合物的存在水平优选为约0.5%至约60%,任选约1%至约50%,任选约5%至约40%,任选约10%至约25%。
过氧化物复合物可包括过氧化合物和多孔交联聚合物。本文所指的“过氧化合物”是包含二价氧-氧基团的氧化性化合物。过氧化合物包括过氧化物和氢过氧化物,如过氧化氢、碱金属和碱土金属的过氧化物、有机过氧化合物、过氧酸及其药物可接受的盐和它们的混合物。碱金属和碱土金属的过氧化物包括过氧化锂、过氧化钾、过氧化钠、过氧化镁、过氧化钙、过氧化钡和它们的混合物。有机过氧化合物包括过氧化脲(也称脲过氧化氢)、甘油基过氧化氢、烷基过氧化氢、二烷基过氧化物、烷基过氧酸、过氧化酯、二酰基过氧化物、过氧化苯甲酰和单过氧邻苯二甲酸盐和它们的混合物。过氧酸和它们的盐包括有机过氧酸如烷基过氧酸和单过氧邻苯二甲酸盐和它们的混合物,也包括无机过氧酸盐例如碱金属和碱土金属如锂、钾、钠、镁、钙和钡的过硫酸盐、二过硫酸盐、过碳酸盐、过磷酸盐、过硼酸盐和过硅酸盐,以及它们的混合物。在各个实施方案中,过氧化合物包括过氧化氢、过氧化脲、过碳酸钠和它们的混合物。在一个实施方案中,过氧化合物包括过氧化氢。在一个实施方案中,过氧化合物基本上由过氧化氢组成。
过氧化物复合物包含多孔交联聚合物。本文所指的“多孔交联聚合物”是能有效地吸着(sorb)过氧化合物的颗粒聚合物材料。术语“吸着”指聚合物颗粒吸附、吸收、复合或以别的方式保留过氧化合物的“吸着性”能力(或“吸着”能力)。本文所用的“多孔”指交联聚合物之间的空穴或间隙的存在,其会使聚合物的总表面积超出仅进行周长测量所得的表面积。不想限制本发明的机制、功能或效用,但应认识到在一些实施方案中,过氧化物复合物包含具有非光滑表面的聚合物颗粒和其中保留着过氧化合物的不规则聚合物基质。颗粒的这些化学和物理特性能阻碍过氧化合物从聚合物颗粒的释放,在一些实施方案中能提供过氧化合物的缓释。
在各个实施方案中,聚合物包含的多孔颗粒其BET(Brunauer、Emmett和Teller方法)孔体积为约0.05至约0.3cc/g,任选约0.1至约0.2cc/g,任选约0.14至约0.16cc/g。过氧化物复合物优选以过氧化物复合物的约50%至约95%、任选约70%至约90%重量的水平包含过氧化合物。
交联聚合物优选是至少一种、优选至少两种具有至少两个不饱和键的单体(下文称“多不饱和”单体)的聚合产物,所述被聚合的单体包括不超过约40%重量、优选小于9%总单体重量的单不饱和共聚单体。多不饱和单体选自聚丙烯酸酯、聚甲基丙烯酸酯、聚衣康酸酯和它们的混合物。包括以下物质的聚丙烯酸酯、聚甲基丙烯酸酯或聚衣康酸酯:乙二醇、丙二醇;二、三、四或聚乙二醇和丙二醇;三羟甲基丙烷、甘油、赤藓糖醇、木糖醇、季戊四醇、双季戊四醇、山梨糖醇、甘露糖醇、葡萄糖、蔗糖、纤维素、羟基纤维素、甲基纤维素、1,2-或1,3-丙二醇、1,3-或1,4-丁二醇、1,6-己二醇、1,8-辛二醇、环己二醇、环己三醇和它们的混合物。类似地,可以使用双(丙烯酰胺基或甲基丙烯酰胺基)化合物。这些化合物例如是亚甲基双(丙烯或甲基丙烯)酰胺、1,2-二羟基亚乙基双(丙烯或甲基丙烯)酰胺、六亚甲基双(丙烯或甲基丙烯)酰胺。在一个优选的实施方案中,多不饱和单体是聚甲基丙烯酸酯。
另一批可适宜地应用于本发明的单体包括二或聚乙烯酯,如二乙烯基丙烯脲、草酸二乙烯酯、丙二酸二乙烯酯、琥珀酸二乙烯酯、谷氨酸二乙烯酯、己二酸二乙烯酯、癸二酸二乙烯酯、马来酸二乙烯酯、富马酸二乙烯酯、柠康酸二乙烯酯和中康酸二乙烯酯。其它合适的多不饱和单体包括二乙烯基苯、二乙烯基甲苯、酒石酸二烯丙酯、丙酮酸烯丙酯、马来酸烯丙酯、酒石酸二乙烯酯、三烯丙基三聚氰胺、N,N′-亚甲基双丙烯酰胺、甘油二甲基丙烯酸酯、三甲基丙烯酸甘油酯、马来酸二烯丙酯、二乙烯醚、柠檬酸二烯丙酯一乙二醇酯、柠檬酸乙二醇酯乙烯酯烯丙酯、马来酸烯丙酯乙烯酯、衣康酸二烯丙酯、衣康酸的乙二醇三酯、二乙烯基砜、六氢-1,3,5-三丙烯基三嗪、亚磷酸三丙烯酯、苯膦酸的二烯丙基醚、马来酸酐三乙二醇聚酯、聚烯丙基蔗糖、聚烯丙基葡萄糖、二丙烯酸蔗糖酯、二甲基丙烯酸葡萄糖酯、季戊四醇二、三和四丙烯酸酯或甲基丙烯酸酯、三羟甲基丙烷二和三丙烯酸酯或甲基丙烯酸酯、丙烯酸山梨糖醇酯二甲酯、甲基丙烯酸-2-(1-吖丙啶基)乙酯、三乙醇胺二丙烯酸酯或二甲基丙烯酸酯、三乙醇胺三丙烯酸酯或三甲基丙烯酸酯、酒石酸二甲基丙烯酸酯、三乙二醇二甲基丙烯酸酯、双羟基乙基乙酰胺的二甲基丙烯酸酯和它们的混合物。
其它合适的多烯键式不饱和交联单体包括二甘醇双丙烯酸酯、邻苯二甲酸二烯丙酯、三甲醇基丙烷三甲基丙烯酸酯、乙二醇、甘油、季戊四醇、二甘醇、乙二醇一硫代和二硫代衍生物及间苯二酚的聚乙烯基和聚烯丙基醚;二乙烯基酮、二乙烯基硫、丙烯酸烯丙酯、富马酸二烯丙酯、琥珀酸二烯丙酯、碳酸二烯丙酯、丙二酸二烯丙酯、草酸二烯丙酯、己二酸二烯丙酯、癸二酸二烯丙酯、酒石酸二烯丙酯、硅酸二烯丙酯、丙三羧酸三烯丙酯、乌头酸三烯丙酯、柠檬酸三烯丙酯、磷酸三烯丙酯、二乙烯基萘、二乙烯基苯、三乙烯基苯;苯核上取代有1-4个含1-2个碳原子的烷基的烷基二乙烯基苯;苯核上取代有1-3个含1-2个碳原子的烷基的烷基三乙烯基苯;三乙烯基萘、聚乙烯基蒽和它们的混合物。另外,丙烯基或甲基丙烯基封端的硅氧烷和聚硅氧烷、甲基丙烯酰基封端的聚氨酯、聚硅氧烷醇的聚氨酯丙烯酸酯、双酚A双甲基丙烯酸酯和乙氧基化双酚A双甲基丙烯酸酯也适合作为多不饱和单体。
还另一批单体的代表是乙烯、丙烯、丁烯等、乙二醇、甘油、季戊四醇、山梨糖醇的二烯丙基醚或聚烯丙基醚,二烯丙基或聚烯丙基化合物如基于乙二醇、甘油等的二烯丙基或聚烯丙基化合物,或乙烯基烯丙基化合物或乙烯基丙烯酰基化合物的组合如甲基丙烯酸乙烯酯、丙烯酸乙烯酯、甲基丙烯酸烯丙酯、丙烯酸烯丙酯、甲基丙烯酸甲代烯丙酯或丙烯酸甲代烯丙酯。另外,芳族化合物、环脂族化合物和杂环化合物也适合于本发明。这些化合物包括二乙烯基苯、二乙烯基甲苯、二乙烯基联苯、二乙烯基环己烷、三乙烯基苯、二乙烯基吡啶和二乙烯基哌啶。此外,可使用例如美国专利第3,759,880号、第3,992,562号和第4,013,825号(每个专利的内容通过引用结合到本文中)中所述的二乙烯基乙烯脲或二乙烯基丙烯脲和类似的化合物。如美国专利第4,276,402号和第4,341,889号中所述的丙烯酰基或甲基丙烯酰基封端的硅氧烷和聚硅氧烷可适合于本发明。如美国专利第4,224,427号、第4,250,32号和第423,099号(每个专利的内容通过引用结合到本文中)中所述的甲基丙烯酰基封端的聚氨酯可适合于本发明。如美国专利第4,543,398号和第4,136,250号(每个专利的内容通过引用结合到本文中)中所述的聚硅氧烷醇的氨酯丙烯酸酯以及双酚A双甲基丙烯酸酯和乙氧基化双酚A双甲基丙烯酸酯也是本发明的合适单体。
单烯键式不饱和单体以占单体总重量的至多约40%重量、优选不超过约9%重量的量,也可适合用于制备聚合物微颗粒,所述单体包括乙烯、丙烯、异丁烯、二异丁烯(disobutylene)、苯乙烯、乙烯基吡啶乙基乙烯基苯、乙烯基甲苯和二环戊二烯;丙烯酸和甲基丙烯酸的酯,包括甲酯、乙酯、丙酯、异丙酯、丁酯、仲丁酯、叔丁酯、戊酯、己酯、辛酯、乙基己酯、癸酯、十二烷基酯、环己酯、异冰片酯、苯酯、苄酯、烷基苯酯、乙氧基甲酯、乙氧基乙酯、乙氧基丙酯、丙氧基甲酯、丙氧基乙酯、丙氧基丙酯、乙氧基苯酯、乙氧基苄酯和乙氧基环己酯;乙烯酯,包括乙酸乙烯酯、丙酸乙烯酯、丁酸乙烯酯和月桂酸乙烯酯;乙烯基酮,包括乙烯基甲基酮、乙烯基乙基酮、乙烯基异丙基酮和甲基异丙烯基酮;乙烯基醚,包括乙烯基甲基醚、乙烯基乙基醚、乙烯基丙基醚和乙烯基异丁基醚等。
以占单体溶液中单体总重量的至多约40%重量或以下、优选不超过约25%重量、最优选不超过约9%重量的量,可按照本发明使用的其它单不饱和单体材料,包括α-、β-不饱和羧酸的羟基烷基酯,如丙烯酸-2-羟乙酯或甲基丙烯酸-2-羟乙酯、丙烯酸羟丙酯或甲基丙烯酸羟丙酯等。丙烯酸或甲基丙烯酸的上述酯以外的许多衍生物也适合作为单不饱和单体原料用于形成本发明的不饱和聚合物微颗粒。这些单体包括但不限于以下单体:甲基丙烯酰乙醇酸,乙二醇、甘油和其它多元醇的单甲基丙烯酸酯,二烷撑二醇(dialkylene glycol)和多烷撑二醇(polyalkylene glycol)的单甲基丙烯酸酯等。在每种情况下都可用对应的丙烯酸酯代替甲基丙烯酸酯。实例包括以下:丙烯酸-2-羟乙酯或甲基丙烯酸-2-羟乙酯、二乙二醇丙烯酸酯或甲基丙烯酸酯、丙烯酸-2-羟丙酯或甲基丙烯酸-2-羟丙酯、丙烯酸-3-羟丙酯或甲基丙烯-3-羟丙酯酸、四乙二醇丙烯酸酯或四乙二醇甲基丙烯酸酯、五乙二醇丙烯酸酯或五乙二醇甲基丙烯酸酯、二丙二醇丙烯酸酯或二丙二醇甲基丙烯酸酯、丙烯酰胺、甲基丙烯酰胺、双丙酮丙烯酰胺、羟甲基丙烯酰胺、羟甲基甲基丙烯酰胺和具有一个或多个1-30个碳原子、优选5-18个碳原子的直链或支链烷基的任何丙烯酸酯或甲基丙烯酸酯等。其它合适的实例包括甲基丙烯酸异冰片酯、甲基丙烯酸苯氧基乙酯、甲基丙烯酸异癸酯、甲基丙烯酸硬脂酸酯、甲基丙烯酸羟丙酯、甲基丙烯酸环己酯、甲基丙烯酸二甲氨基乙酯、甲基丙烯酸叔丁氨基乙酯、2-丙烯酰胺丙烷磺酸、甲基丙烯酸-2-乙基己酯、甲基丙烯酸甲酯、甲基丙烯酸乙酯、甲基丙烯酸丁酯、甲基丙烯酸-2-羟乙酯、甲基丙烯酸四氢糠酯和甲基丙烯酸甲氧基乙酯。
含有羧酸基团作为官能团、适合用作本发明原料的单不饱和单体的实例包括以下:丙烯酸、甲基丙烯酸、衣康酸、乌头酸、肉桂酸、巴豆酸、中康酸、马来酸、富马酸等。
上述酸的偏酯也适合作为用于本发明的单不饱和单体。这种酯的实例包括以下:乌头酸单(2-羟基)丙酯、马来酸单(2-羟基)乙酯、富马酸单(2-羟基)丙酯、衣康酸单乙酯、衣康酸的单甲基乙二醇一乙醚酯、马来酸的单甲基乙二醇一乙醚酯等。
含有氨基作为官能团的合适单不饱和单体的实例包括以下:丙烯酸二乙氨基乙酯或甲基丙烯酸二乙氨基乙酯、丙烯酸二甲氨基乙酯或甲基丙烯酸二甲氨基乙酯、丙烯酸一乙氨基乙酯或甲基丙烯酸一乙氨基乙酯、甲基丙烯酸叔丁氨基乙酯、对氨基苯乙烯、邻氨基苯乙烯、2-氨基-4-乙烯基甲苯、甲基丙烯酸哌啶子基乙酯、甲基丙烯酸吗啉代乙酯、2-乙烯基吡啶、3-乙烯基吡啶、4-乙烯基吡啶、2-乙基-5-乙烯基吡啶、丙烯酸二甲氨基丙酯和甲基丙烯酸二甲氨基丙酯、二甲氨基乙基乙烯基醚、二甲氨基乙基乙烯基硫醚、二乙氨基乙基乙烯基醚、氨基乙基乙烯基醚、甲基丙烯酸-2-吡咯烷酮基乙酯、丙烯酸-3-二甲氨基乙基-2-羟丙酯或甲基丙烯酸-3-二甲氨基乙基-2-羟丙酯、丙烯酸-2-氨基乙酯或甲基丙烯酸-2-氨基乙酯、异丙基甲基丙烯酰胺、N-甲基丙烯酰胺或N-甲基甲基丙烯酰胺、2-羟乙基丙烯酰胺或2-羟乙基甲基丙烯酰胺、氯化或磺甲酸1-甲基丙烯酰基-2-羟基-3-三甲基铵、甲基丙烯酸-2-(1-吖丙啶基)乙酯等。通常表现得如同只具有一个不饱和基团的多烯键式不饱和单体,如异丙烯、丁二烯和氯丁二烯,不应计算为多不饱和单体含量的一部分,而应计算为单烯键式不饱和单体含量的一部分。
在一个实施方案中,使用了两者聚合的多不饱和单体。用乙二醇二甲基丙烯酸酯聚合的甲基丙烯酸烯丙酯特别适合于捕集过氧化物而形成过氧化物复合物。在这个实施方案中,双不饱和单体还起到交联剂的作用。这一具体聚合产物是看似粉末的聚合物多孔球体。
在一个实施方案中,可用于本发明的聚合物颗粒用包括以下步骤的方法制备:(a)将至少一种、优选至少两种多不饱和单体,优选与有效量的有机聚合引发剂一起,溶于水不混溶性硅酮液溶剂中,以提供单体混合物;(b)慢慢搅动溶解的单体和硅酮溶剂;(c)在单体在硅酮液中聚合的过程中继续慢慢搅动,以产生微孔聚合物微颗粒及其附聚物(agglomerate);(d)使微孔聚合物微颗粒和附聚物与硅酮溶剂分离,产生球体形式的微孔聚合物微颗粒和聚集体(aggregate)。在各个实施方案中,球体聚集体和球体附聚物的直径小于约500微米,优选小于约100微米,更优选小于约80微米。
可用于本发明的多孔交联聚合物有美国专利第5,955,552号和第6,387,995号(每个专利的内容通过引用结合到本文中)中公开的多孔交联聚合物。这种聚合物包括以下市售聚合物:5640,美国加州Redwood City的A.P.Pharma出售;6603和200系列,美国伊利诺斯州Arlington Heights的Amcol International Corp出售;-12系列和-12系列,美国新泽西州South Plainfield的Kobo Products,Inc.出售。
本发明提供包含口腔可接受载体的组合物。具体载体组分的选择取决于所需的产品形式,如洁齿剂、润丝、粉末、凝胶、糖食和油彩。在各个实施方案中,载体有助于使过氧化物复合物粘着到施加组合物的口腔当中的表面,而不必伴随使用牙齿托盘或类似的用具。但是,载体也能有效地与线带、托盘、牙套或类似的用具一起使用。
可在载体中使用的材料包括粘合剂、粘度改进剂、稀释剂、表面活性剂、泡沫调节剂、过氧化物活化剂、过氧化物稳定剂、磨料、pH调节剂、湿润剂、口感剂、甜味剂、香料、着色剂和它们的组合。
载体可包括粘合剂,如能增强过氧化物复合物在口腔表面上的保持的材料或材料组合。这种粘合剂可包括胶粘剂、成膜材料、增粘剂和它们的组合。示例性的材料包括亲水性有机聚合物、疏水性有机聚合物、硅橡胶、二氧化硅和它们的组合。因此,本发明提供包含以下成分的口腔护理组合物:(a)包含过氧化合物和多孔交联聚合物的过氧化物复合物;(b)非水载体,优选包含粘合剂的非水载体,所述粘合剂优选选自胶粘剂、成膜材料、增粘剂和它们的组合,优选包含选自亲水性有机聚合物、疏水性有机聚合物、硅橡胶、二氧化硅和它们的组合的材料。在一个实施方案中,粘合剂包含成膜材料。
可用于本发明的亲水性有机聚合物包括聚乙二醇、环氧乙烷的非离子聚合物、环氧乙烷和环氧丙烷的嵌段共聚物、羧亚甲基聚合物、N-乙烯基杂环聚合物和它们的混合物。可用于实施本发明的非水亲水性聚合物优选给组合物提供约10,000cps至600,000cps范围内的粘度。
亲水性聚合物还包括聚乙二醇和环氧乙烷的聚合物,通式为:HOCH2(CH2OCH2)nOH,其中n代表氧乙烯基团的平均数。获自Dow Chemical(Midland,美国密歇根州)的聚乙二醇由诸如200、300、400、600、2000的数字标示,这些数字表示聚合物的大约平均分子量。聚乙二醇200、300、400和600在常温下是透明粘稠液体,优选用于本发明的实施。
另一类可用于本发明的亲水性聚合物由水溶性的环氧乙烷和环氧丙烷非离子嵌段共聚物组成,所述共聚物为下式:HO(C2H4O)a(C3H6O)b(C2H4O)cH。优选选择该嵌段共聚物(就a、b和c进行)使得环氧乙烷组分占共聚物分子的约65至约75%重量,共聚物的平均分子量为约2,000至约15,000,且共聚物在口腔护理组合物中的存在浓度使得该组合物在室温下(23℃)为液体。
可用于本发明的嵌段共聚物是Pluraflo L1220,其平均分子量为约9,800。亲水性聚(环氧乙烷)嵌段平均占聚合物的约65%重量。
可用作粘合增强剂的有机聚合物包括亲水性聚合物如卡波姆如羧亚甲基聚合物如丙烯酸聚合物和丙烯酸共聚物。聚羧乙烯是具有活性羧基的微酸性乙烯基聚合物。一种这样的聚合物是美国俄亥俄州Cleveland的Noveon,Inc.出售的974。
可用于本发明的N-乙烯基杂环聚合物包括从N-杂环乙烯基单体衍生的聚合物,优选包括含有乙烯基、杂环中具有3-7个原子(包括羰基碳原子和氮杂原子)的N-乙烯基杂环单体。优选所述环含有5或6个原子,包含杂原子如硫或氧,且可被取代或未被取代。某些实施方案是具体的N-乙烯基杂环单体的聚合物,如N-乙烯基酰亚胺聚合形成聚-N-乙烯基聚亚胺,N-乙烯基内酰胺聚合形成聚-N-乙烯基聚内酰胺,及它们的混合物。在一个优选的实施方案中,聚合物是聚-N-乙烯基-聚-2-吡咯烷酮。聚-N-乙烯基-聚-2-吡咯烷酮通常也称聚乙烯吡咯烷酮或“PVP”。聚合物包括可溶性和不溶性均聚PVP。含有PVP的共聚物包括乙烯吡咯烷酮/乙酸乙烯酯(也称Copolyvidone、Copolyvidonum或VP-VAc)和乙烯吡咯烷酮/甲基丙烯酸二甲氨基乙酯。可用于本发明的可溶性PVP聚合物是本领域公知的,包括Povidone、Polyvidone、Polyvidonum、聚(N-乙烯基-2-吡咯烷酮(pyrrolidinone))、聚(N-乙烯基丁内酰胺)、聚(1-乙烯基-2-吡咯烷酮(pyrrolidone)和聚[1-(2-氧代-1-吡咯烷基)乙烯]。这些PVP聚合物没有充分地发生交联。在本发明的各个实施方案中,优选不溶性交联均聚物。这种聚合物包括本领域常称之为交联聚乙烯吡咯烷酮、交联聚维酮和cPVP的聚合物,本文称之为“cPVP”。
可作为粘合增强剂用于实施本发明的疏水性有机材料,包括疏水性材料如蜡如蜂蜡、矿物油、矿物油和聚乙烯掺合物、矿脂、白矿脂、液体石蜡、(丁烷/乙烯/苯乙烯氢化共聚物)掺合物(美国德克萨斯州Houston的Penreco出售)、丙烯酸酯和乙酸乙烯酯聚合物和共聚物、聚乙烯蜡、下文进一步讨论的硅酮聚合物和聚乙烯吡咯烷酮/乙酸乙烯酯共聚物。在本发明含疏水性聚合物的实施方案中,疏水性聚合物的比例占组合物的约1至约85%重量。
可用于本发明的硅酮聚合物包括但不限于硅酮胶粘剂、硅酮弹性体、硅酮液、硅酮树脂、硅酮胶和它们的混合物。在一个实施方案中,载体包含压敏胶(PSA)组合物,包括本领域公知的组合物。通常,硅酮基PSA通过将硅酮树脂和有机硅氧烷如聚二有机硅氧烷缩合来生产。合适的硅酮聚合物包括将硅烷醇封端的聚二有机硅氧烷如聚二甲基硅氧烷与含硅烷醇的硅酮树脂混合成共聚物产物,从而聚二有机硅氧烷的硅烷醇基团与硅酮树脂的硅烷醇基团发生缩合反应,结果聚二有机硅氧烷被硅酮树脂轻度交联(即聚二有机硅氧烷链通过树脂分子粘结在一起,产生链分支和缠结和/或少量的网络特性),形成硅酮压敏胶。可将催化剂(例如碱性材料如氨、氢氧化铵或碳酸铵)与硅烷醇封端的聚二有机硅氧烷和硅酮树脂混合,以促进这一交联反应。将硅酮树脂与硅烷醇封端的聚二有机硅氧烷共聚合,得到了自粘性和内聚性软弹性体基质。改变压敏胶的硅酮树脂与聚二有机硅氧烷比例将改变口腔护理组合物的粘着性。例如PSA可获自美国密歇根州Midland的Dow-Corning Corporation,商标为BIO-PSA。硅酮基压敏胶在本发明液体增白组合物中的存在浓度为约0.5%至约99%。
可用于本发明的硅酮胶包括在25℃下粘度为约500,000cS直至约50,000,000cS的高分子量聚二有机硅氧烷。这种硅酮胶包括平均分子量大于500,000的聚二有机硅氧烷。用于本发明的聚硅氧烷胶可以是线性的或环状的、支链的或非支链的。取代基可具有任何结构,只要所得的聚硅氧烷是疏水的,当应用到口腔时没有刺激性、毒性或其它方面的有害性,且与组合物的其它组分相容。硅氧烷胶的具体实例包括聚(二甲基硅氧烷-甲基乙烯基硅氧烷)共聚物、聚(二甲基硅氧烷-二苯基甲基乙烯基硅氧烷)共聚物和它们的混合物。
可用于本发明的聚硅氧烷液包括在25℃下粘度为约1cS至约1000cS,任选约2cS至约500cS,或约5cS至约400cS的聚硅氧烷液。用于本发明的聚硅氧烷液可以是线性的或环状的,且可被多种取代基(包括上述取代基)取代。优选的取代基包括甲基、乙基和苯基取代基。合适的聚硅氧烷液包括线性聚硅氧烷聚合物,如聚二甲基硅氧烷和其它低粘度聚硅氧烷材料类似物,优选在25℃下粘度为200cS或以下,及环甲基硅氧烷和在25℃下粘度例如为200cS或以下的其它环状硅氧烷。
粘合剂还包括无机材料。这种无机材料包括硅聚合物如起到增稠剂作用的无定形二氧化硅化合物(热解二氧化硅,美国麻萨诸塞州波士顿市的Cabot Corporation制造;15,也称15,美国马里兰州哥伦比亚市的Davison ChemicalDivision of W.R.Grace & Co.出售)。优选的粘合剂是Dow-CorningCorporation出售的Dow Corning Silicone Adhesive 8-7016。
可用于本发明的增稠剂包括羧基乙烯基聚合物,卡拉胶(也称角叉菜,更具体的说是ι-卡拉胶),纤维素聚合物如羟乙基纤维素、羧甲基纤维素及其盐(例如羧甲基纤维素钠),天然胶如刺梧桐胶、黄原胶、阿拉伯树胶和黄蓍胶,胶态硅酸铝镁,胶态二氧化硅及它们的混合物。一种或多种增稠剂的存在总量任选占组合物重量的约0.01%至约15%,例如约0.1%至约10%或约0.2%至约5%。
可用于本发明的粘度改进剂包括矿物油、矿脂、粘土和有机改性粘土、二氧化硅和它们的混合物。在各个实施方案中,这种粘度改进剂能有效地抑制液体组合物各成分的沉淀或分离,或者在搅动液体组合物时能促进其再分散性一种或多种粘度改进剂的存在总量任选占组合物的约0.01%至约10%,例如约0.1%至约5%重量。
可用于本发明的稀释剂包括能有效地使组合物的其它组分溶解和/或悬浮的材料或材料组合。在各个实施方案中,稀释剂任选与粘度改进剂(如本文所述的)和组合物的其它组分联合一起,有效地调节组合物的粘度。在各个实施方案中,组合物是非水组合物,即不含有明显数量的化学未结合水。稀释剂包括甘油和无水乙醇。稀释剂在本发明的非水液体增白组合物中的存在量为约0.1%至约90%,任选在各个实施方案中为约0.5%至约70%、约0.5%至约50%、约0.5%至约35%。
可用于本发明的表面活性剂包括阴离子型、非离子型和两性型表面活性剂。表面活性剂可例如用于增强配方的稳定性,帮助通过去污作用清洁口腔表面,和在搅动时例如在用本发明的洁齿剂组合物刷洗过程中产生泡沫。合适的阴离子型表面活性剂包括水溶性的C8-20烷基硫酸盐、磺化的C8-20脂肪酸单甘油酯、肌氨酸盐、牛磺酸盐等。这些和其它表面活性剂的示例性实例是十二烷基硫酸钠、椰油酸单甘油酯磺酸钠、十二烷基肌氨酸钠、十二烷基异乙二磺酸钠(sodiumlauryl isoethionate)、月桂基聚氧乙烯醚羧酸钠和十二烷基苯磺酸钠及它们的混合物。合适的非离子型表面活性剂包括泊洛沙姆、聚氧乙烯失水山梨糖醇酯、脂肪醇聚氧乙烯醚、烷基酚乙氧基化物、叔胺氧化物、叔膦氧化物、二烷基亚砜等。合适的两性型表面活性包括具有阴离子基团例如羧酸根、硫酸根、磺酸根、磷酸根或膦酸根的C8-20脂肪族仲胺和叔胺的衍生物。合适的实例是椰油酰胺丙基甜菜碱。一种或多种表面活性剂的存在总量任选为约0.01%至约10%,例如约0.05%至约5%或约0.1%至约2%。优选地,表面活性剂为非离子型,与过氧化合物如聚环氧乙烷相容。非离子型表面活性剂在本发明各个实施方案中的存在水平为约0.01%至约1%。
可用于本发明的泡沫调节剂包括能有效地增加在搅动时由组合物(例如洁齿剂组合物)产生的泡沫的数量、厚度或稳定性的材料。可使用任何口腔可接受的泡沫调节剂,包括聚乙二醇(PEG,也称聚氧乙烯)。高分子量PEG是适合的,包括平均分子量为约200,000至约7,000,000、例如约500,000至约5,000,000或约1,000,000至约2,500,000的PEG。一种或多种PEG的存在总量任选为约0.1%至约10%,例如约0.2%至约5%或约0.25%至约2%。
可用于本发明的湿润剂包括多元醇如甘油、山梨糖醇、木糖醇或低分子量PEG。在各个实施方案中,湿润剂能有效地防止糊膏或凝胶组合物暴露于空气时发生硬化。在各个实施方案中,湿润剂还起到甜味剂的作用。一种或多种湿润剂的存在总量任选为约1%至约50%,例如约2%至约25%或约5%至约15%。
本发明的组合物中可掺入过氧化物活化剂如碳酸氢钠、碳酸钠、葡糖酸锰。活化剂在非水液体组合物中对过氧化物增白剂相对无活性。
可用于本发明的pH调节剂包括降低pH的酸化剂、提高pH的碱化剂和控制pH在所需范围内的缓冲剂。可使用任何口腔可接受的pH调节剂,包括但不限于羧酸、磷酸和磺酸、酸式盐(例如柠檬酸一钠、柠檬酸二钠、苹果酸一钠等)、碱金属氢氧化物如氢氧化钠,碳酸盐如碳酸钠、碳酸氢盐、倍半碳酸盐、硼酸盐、硅酸盐、磷酸盐(例如磷酸一钠、磷酸三钠、焦磷酸盐等)、咪唑以及它们的混合物。一种或多种pH调节剂任选以能有效维持组合物在口腔可按受pH范围内的总量存在。
口感剂包括在组合物的使用过程中赋予期望的质地或其它感觉的材料。这种口感剂包括碳酸氢盐,可以使用口腔可接受的碳酸氢盐,包括但不限于碱金属碳酸氢盐如碳酸氢钠和碳酸氢钾、碳酸氢铵以及它们的混合物。一种或多种碳酸氢盐的存在总量任选为约0.1%至约50%,例如约1%至约20%。
可用于本发明的香料包括任何能有效地增强组合物的味道的材料或材料混合物。可使用任何口腔可接受的天然或合成香料,如风味油、风味醛、酯、醇、类似材料以及它们的组合。香料还涵括在口中提供芳香和/或其它感官效果,包括清凉或温热效果的成分。这种成分包括薄荷醇、乙酸酯、乳酸酯、樟脑、桉树油、桉树脑、茴香脑、丁子香酚、肉桂、4-(对羟基苯基)-2-丁酮、α-紫罗兰酮、丙烯基愈创木酚(propenyl guaiethol)、百里酚、芳樟醇、苯甲醛、肉桂醛、N-乙基-p-薄荷-3-甲酰胺、N,2,3-三甲基-2-异丙基丁酰胺、3-1-氧基丙-1,2-二醇,肉桂醛甘油缩醛(CGA)、薄荷酮甘油缩醛(MGA)以及它们的混合物。
可用于本发明的甜味剂包括口腔可接受的天然或人工的营养性或非营养性甜味剂。这种甜味剂包括右旋糖、聚右旋糖、蔗糖、麦芽糖、糊精、干转化糖、甘露糖、木糖、核糖、果糖、左旋糖、半乳糖、玉米糖浆(包括高果糖玉米糖浆和玉米糖浆固形物)、部分水解淀粉、氢化淀粉水解物、山梨糖醇、甘露糖醇、木糖醇、麦芽糖醇、益寿糖(isomalt)、天冬甜素、纽甜(neotame)、糖精及其盐、三氯半乳蔗糖、二肽基强甜味剂(intense sweetener)、环己基氨基磺酸盐、双氢查耳酮以及它们的混合物。
可用于本发明的着色剂包括颜料、染料、色淀和赋予特殊光泽或反射率的物剂如珠光剂。可使用任何口腔可接受的着色剂,包括滑石粉、云母、碳酸镁、碳酸钙、硅酸镁、硅酸铝镁、二氧化硅、二氧化钛、氧化锌、红色、黄色、棕色和黑色氧化铁、亚铁氰化铁铵、锰紫、群青、钛云母、氯氧化铋以及它们的混合物。
在一个实施方案中,本发明提供包含以下成分的组合物:(a)约0.5%至约60%的过氧化物复合物;(b)约0.5%至约60%的硅酮胶粘剂。任选地,所述组合物另外包含约1至约99%的硅酮液。任选地,所述组合物另外包含约1%至约40%的疏水性聚合物,如矿物油和聚乙二醇的掺合物。
本发明的组合物任选包含磨料。在各个实施方案中,磨料例如可用作磨光剂。可使用任何口腔可接受的磨料,但应选择磨料的类型、细度(颗粒大小)和数量,使得在正常使用组合物时牙釉质不会被过度磨损。合适的磨料包括二氧化硅,例如为二氧化硅凝胶、水合二氧化硅或沉淀二氧化硅的形式,氧化铝,不溶性磷酸盐,碳酸钙,树脂磨料例如脲-甲醛缩合产物以及它们的混合物。可用作磨料的不溶性磷酸盐有正磷酸盐、聚偏磷酸盐和焦磷酸盐。示例性的实例是二水合正磷酸二钙、焦磷酸钙、β-焦磷酸钙、磷酸三钙、聚偏磷酸钙和不溶性聚偏磷酸钠。
本发明的组合物任选可包括任何其它适宜用于具体口腔组合物中的活性或惰性成分,如牙垢控制剂、防龋剂、氟离子源、亚锡离子源、锌离子源、消炎剂、抗细菌剂、抗氧化剂、催涎剂、口腔清新剂、防牙菌斑剂、抗细菌粘附剂、脱敏剂、酶和抗结石剂。
本发明的组合物任选包含可例如用作防龋剂的氟离子源。可以使用任何口腔可接受的氟离子源,包括氟化钾、氟化钠和氟化铵及单氟磷酸盐、氟化亚锡、氟化铟、氟化胺类如奥拉氟(olaflur,N′-十八烷基丙二胺-N,N,N′-三(2-乙醇)二氟化氢)以及它们的混合物。在各个实施方案中,使用水溶性氟离子源。一种或多种氟离子源任选以能提供总共约0.0025%至约2%,例如约0.005%至约1%或约0.01%至约0.3%的氟离子的量存在。
本发明的组合物可通过任何多种方法来制备,包括通过将组合物的各成分加入到装有混合器的合适容器如不锈钢罐中进行混合来制备。在一个实施方案中,按以下顺序将组合物各组分加入到混合容器中:液体成分、增稠剂成分、过氧化物复合物和任何香料、着色剂或甜味剂。尽管不限定严格的混合顺序,但在一些实施方案中优选过氧化物复合物是加入到多组分组合物中的最后几种组分之一。然后将各成分混合以形成均匀的分散液/溶液。
本发明提供使用本发明的组合物增白牙齿表面的方法。本文所指的“牙齿”指的是天然牙齿、义齿、牙板、牙齿充填物、牙帽、牙冠、齿桥、牙科植入物等,以及任何其它永久或暂时固定在口腔中的硬质表面的牙修复体。本文所用的“增白”指的是牙齿视觉外观的变化,优选使得牙齿白度提高。牙齿表面白度的提高可视觉观察到,例如借助颜色比较图或量具进行视觉观察,或者使用任何合适的仪器如Minolta色度计(例如CR-400型,Minolta Corp.,Ramsey,美国新泽西州)通过比色法测量。该仪器可设定程序,例如按照国际照明委员会(CIE)制定的标准测量Hunter Lab值或L*a*b*值。L*a*b*系统提供三维色空间的数值表示方式,其中L*表示光亮度轴,a*表示红-绿轴,b*表示黄-蓝轴。通常L*轴和b*轴最适合于牙齿白度的测量。可由处理前和处理后的L*值、a*值和b*值的差值,或者未经处理表面和经处理表面之间的L*值、a*值和b*值的差值,计算出白度的提高。有用的参数是ΔE*,其按以下公式计算为L*值、a*值和b*值之差的平方和的平方根:ΔE*=[(ΔL*)2+(Δa*)2+(Δb*)2]1/2ΔE*值越大表示白度提高程度越大。在各个实施方案中,本发明的方法可实现的ΔE*为至少约1,或者至少约3,或者至少约5。
因此,本发明提供用以增白牙齿表面的方法,所述方法包括向牙齿表面施加安全和有效量的包含过氧化合物和多孔交联聚合物的过氧化物复合物。优选地,所述方法包括施加包含过氧化物复合物和载体的本发明组合物。本文所指的“施加”指的是任何将过氧化物复合物放置成与牙齿表面相接触的方法。在各个实施方案中,这种方法包括通过诸如漱洗法、涂擦法和刷洗法直接施加组合物。在各个实施方案中,组合物的施加包括使用施加装置,该装置能帮助保持过氧化物复合物与牙齿表面接触足够的时间以使增白得以发生。
在一个优选的实施方案中,增白组合物用“涂绘(paint on)”技术施加。使小的施加装置如刷子或铲片涂敷上本发明的组合物,然后将组合物放置在牙齿表面上。优选地,将组合物均匀涂敷在牙齿表面上,涂敷数量足以传递增白量的过氧化物复合物。
本发明还提供用以实现氧化性过氧化物物类向牙齿表面上控释的方法,所述方法包括使牙齿表面与本发明的过氧化物复合物接触。本文所指的这种控释在各个实施方案中包括过氧化物复合物的缓释。不想限制本发明的机制、功能或效用,但在一些实施方案中,与唾液的接触会引起过氧化物活性物质从交联聚合物基质慢慢释放到被施加的牙齿部位。这一慢慢释放通过长时间提供有效量的过氧化物的恒定供应来提供增强的增白作用。优选地,使组合物与牙齿表面接触至少约30秒钟,任选至少约1分钟。
本发明通过以下非限制性实施例作进一步的说明。实施例1
将该组合物施加到有牙色斑的人对象的牙齿,导致可察觉的增白。该组合物经测定所提供的ΔE值为约5。实施例2
将所得的组合物进行加速老化(105°F/120°F)几个星期,仍保持稳定,过氧化物剩余超过90%。还对该组合物进行了体外过氧化氢保持试验。在下表给出的试验结果表明,该组合物随时间推移能保持过氧化氢。
保持时间(分钟) | |
所保持的H2O2(%) | |
0 | 100 |
5 | - |
10 | 60 |
20 | 58 |
30 | 51 |
45 | 46 |
60 | 19 |
Claims (25)
1.一种口腔护理组合物,所述组合物包含:
(a) 包含过氧化合物和多孔交联聚合物的过氧化物复合物;和
(b) 口腔可接受载体,
其中所述多孔交联聚合物包括选自聚丙烯酸酯、聚甲基丙烯酸酯、聚衣康酸酯和其混合物的聚合多不饱和单体。
2.权利要求1的口腔护理组合物,其中所述多不饱和单体是聚甲基丙烯酸酯。
3.权利要求1的口腔护理组合物,其中所述多孔交联聚合物包含两种聚合多不饱和单体。
4.权利要求3的口腔护理组合物,其中所述多孔交联聚合物包含与乙二醇二甲基丙烯酸酯聚合的甲基丙烯酸烯丙酯。
5.权利要求1的口腔护理组合物,其中所述多孔交联聚合物的BET孔体积为0.1至0.3 cc/g。
6.权利要求5的口腔护理组合物,其中所述多孔交联聚合物的BET孔体积为0.14至0.16 cc/g。
7.权利要求5的口腔护理组合物,其中所述过氧化物复合物包含以过氧化合物的70%至90%重量的水平吸着到交联聚合物的过氧化合物。
8.权利要求1的口腔护理组合物,其中所述过氧化合物包括过氧化氢。
9.权利要求1的口腔护理组合物,其中所述载体是非水载体。
10.权利要求1的口腔护理组合物,其中所述载体包含选自粘合剂、表面活性剂、过氧化物活化剂、溶剂、香料、甜味剂、着色剂和其混合物的材料。
11.权利要求10的口腔护理组合物,其中所述载体包含选自硅酮聚合物、蜡、矿物油、矿脂、亲水性聚合物、二氧化硅和其混合物的粘合剂。
12.权利要求10的口腔护理组合物,其中所述载体包含选自聚乙二醇、环氧乙烷的非离子聚合物、环氧乙烷和环氧丙烷的嵌段共聚物、羧亚甲基聚合物、聚乙烯吡咯烷酮和其混合物的亲水性聚合物。
13.权利要求10的口腔护理组合物,其中所述载体包含选自硅酮胶粘剂、硅酮弹性体、硅酮液、硅酮树脂、硅酮胶和其混合物的硅酮聚合物。
14.一种口腔护理组合物,所述组合物包含:
(a) 包含过氧化合物和多孔交联聚合物的过氧化物复合物;和
(b) 包含成膜材料的非水载体;
其中所述多孔交联聚合物包括选自聚丙烯酸酯、聚甲基丙烯酸酯、聚衣康酸酯和其混合物的聚合多不饱和单体。
15.权利要求14的口腔护理组合物,其中所述成膜材料包含亲水性聚合物。
16.权利要求14的口腔护理组合物,其中所述载体包含硅酮。
17.权利要求14的口腔护理组合物,其中所述多孔交联聚合物包含包括聚甲基丙烯酸酯的聚合多不饱和单体。
18.权利要求14的口腔护理组合物,其中所述过氧化物复合物包含以活性物质的70%至90%重量的水平吸着到交联聚合物上的过氧化合物。
19.安全和有效量的包含过氧化合物和多孔交联聚合物的过氧化物复合物在制备口腔护理组合物中的用途,所述口腔护理组合物用于增白牙齿表面,所述增白牙齿表面包括向所述表面施加所述过氧化物复合物,所述多孔交联聚合物包括选自聚丙烯酸酯、聚甲基丙烯酸酯、聚衣康酸酯和其混合物的聚合多不饱和单体。
20.权利要求19的用途,其中所述多孔交联聚合物包含包括聚甲基丙烯酸酯的聚合多不饱和单体。
21.权利要求19的用途,其中所述过氧化物复合物包含以活性物质的70%至90%重量的水平吸着到交联聚合物上的过氧化合物。
22.权利要求19的用途,所述增白牙齿表面包括施加非水载体中的过氧化物复合物,所述载体另外包含选自粘合剂、表面活性剂、过氧化物活化剂、溶剂、香料、甜味剂、着色剂和其混合物的材料。
23.权利要求22的用途,其中所述载体包含选自硅酮聚合物、蜡、矿物油、矿脂、亲水性聚合物、二氧化硅和其混合物的粘合剂。
24.权利要求22的用途,其中所述载体包含选自聚乙二醇、环氧乙烷的非离子聚合物、环氧乙烷和环氧丙烷的嵌段共聚物、羧亚甲基聚合物、聚乙烯吡咯烷酮和其混合物的亲水性聚合物。
25.权利要求22的用途,其中所述载体包含选自硅酮胶粘剂、硅酮弹性体、硅酮液、硅酮树脂、硅酮胶和其混合物的硅酮聚合物。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US64065604P | 2004-12-30 | 2004-12-30 | |
US60/640,656 | 2004-12-30 | ||
US11/285,871 | 2005-11-23 | ||
US11/285,871 US20060147394A1 (en) | 2004-12-30 | 2005-11-23 | Tooth whitening composition containing cross-linked polymer-peroxides |
PCT/US2005/046240 WO2006073822A1 (en) | 2004-12-30 | 2005-12-21 | Tooth whitening composition containing cross-linked polymer-peroxides |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101163523A CN101163523A (zh) | 2008-04-16 |
CN101163523B true CN101163523B (zh) | 2013-06-19 |
Family
ID=39298201
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200580048803.3A Expired - Fee Related CN101163523B (zh) | 2004-12-30 | 2005-12-21 | 含有交联聚合物-过氧化物的牙齿增白组合物 |
Country Status (2)
Country | Link |
---|---|
CN (1) | CN101163523B (zh) |
ES (1) | ES2350245T5 (zh) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018093357A1 (en) * | 2016-11-16 | 2018-05-24 | Colgate-Palmolive Company | Oral Care Composition |
WO2018111704A1 (en) | 2016-12-14 | 2018-06-21 | Colgate-Palmolive Company | Aluminum-free antiperspirant/deodorant compositions |
EP3636322B1 (en) * | 2018-10-11 | 2021-07-28 | Cavex Holland BV | Stabilized hydrogen peroxide composition |
GB2594928A (en) * | 2020-05-05 | 2021-11-17 | Biofilm Ltd | Dissolvable hydrogen peroxide teeth whitening strip |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3376110A (en) * | 1967-01-30 | 1968-04-02 | Gen Aniline & Film Corp | Solid stabilized hydrogen peroxide compositions |
US5037485A (en) * | 1989-09-14 | 1991-08-06 | Dow Corning Corporation | Method of cleaning surfaces |
US20040086468A1 (en) * | 2002-10-30 | 2004-05-06 | Isp Investments Inc. | Delivery system for a tooth whitener |
-
2005
- 2005-12-21 CN CN200580048803.3A patent/CN101163523B/zh not_active Expired - Fee Related
- 2005-12-21 ES ES05854884.3T patent/ES2350245T5/es active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3376110A (en) * | 1967-01-30 | 1968-04-02 | Gen Aniline & Film Corp | Solid stabilized hydrogen peroxide compositions |
US5037485A (en) * | 1989-09-14 | 1991-08-06 | Dow Corning Corporation | Method of cleaning surfaces |
US20040086468A1 (en) * | 2002-10-30 | 2004-05-06 | Isp Investments Inc. | Delivery system for a tooth whitener |
Also Published As
Publication number | Publication date |
---|---|
ES2350245T3 (es) | 2011-01-20 |
ES2350245T5 (es) | 2015-07-14 |
CN101163523A (zh) | 2008-04-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
RU2362542C2 (ru) | Композиция для отбеливания зубов, содержащая сшитые полимер-пероксиды | |
CN103720603B (zh) | 含有成膜聚合物的口腔护理组合物 | |
CN102379826B (zh) | 具有交联聚合物过氧化物的口腔护理组合物 | |
RU2404737C2 (ru) | Чистящие и/или полирующие составы и методы их применения | |
JP5502263B2 (ja) | 歯を白化するためのヒドロゲル組成物 | |
TWI355278B (en) | Non-aqueous liquid tooth whitening composition | |
JP2009532374A (ja) | 多成分系漂白組成物および容器 | |
CN101163523B (zh) | 含有交联聚合物-过氧化物的牙齿增白组合物 | |
AU2015417381B2 (en) | Stable whitening oral care dentifrice compositions | |
EP3484437B1 (en) | Dentifrice including zinc and blue dye or pigment |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130619 |