CN101156869A - A medicine for treating hyperphosphatemia disease and iron deficiency anemia disease - Google Patents
A medicine for treating hyperphosphatemia disease and iron deficiency anemia disease Download PDFInfo
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- CN101156869A CN101156869A CNA2007101129490A CN200710112949A CN101156869A CN 101156869 A CN101156869 A CN 101156869A CN A2007101129490 A CNA2007101129490 A CN A2007101129490A CN 200710112949 A CN200710112949 A CN 200710112949A CN 101156869 A CN101156869 A CN 101156869A
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Abstract
The invention relates to medicine treating hyperphospheremia and iron deficiency anemia. Polystyrene sulfoacid ferrous iron resin is used as the effective component of the medicine, the medicine is produced by either adding medical auxiliary material or not, administration is performed by passing through gastrointestinal tract, the effective component and phosphate in the alimentary tract of a patient are combined together to be an insoluble substance which is excreted to the outside of the body through the alimentary tract, thereby the phosphate in the body of a chronic renal failure patient is reduced, and the aim of treating the hyperphospheremia is achieved. Simultaneously, residual ferrous ions of the polystyrene sulfoacid ferrous iron resin are dissociated, and are absorbed by the human body to supplement the ferrous ions in the body, thereby achieving the aim of treating the iron deficiency anemia of the chronic renal failure patient. The medicine can also be used for the treatment of the hyperphospheremia of the chronic renal failure patient and used as the preventive agent of the iron deficiency anemia.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of hyperphosphatemia and iron deficiency anemia.
Background technology
The insufficient patient of chronic renal must regularly accept dialysis treatment usually in long-term, but often presents the situation (more than the 4.5mg/dL) that phosphorus concentration rises in the blood plasma, thereby so-called hyperphosphatemia takes place.Also do not develop direct Therapeutic Method for hyperphosphatemia, thereby generally be the absorption that reduces phosphorus by dietetic therapy, or as symptomatic therapy, oral administration can absorb the method for the Remedies for hyperphosphatemia of phosphate ion in the digestive organ the cause of disease.In general,, can use gel aluminum hydroxide or settled calcium carbonate as Remedies for hyperphosphatemia, and lanthanum carbonate hydrates and sevelamer.
Under the incompetent morbid state of the chronic renal that presents hyperphosphatemia, iron deficiency anemia or metabolic acidosis etc. often take place sometimes, well-known, under such state, anemia is further worsened as if the administration gel aluminum hydroxide.In addition, also know, can be used as gone on the market kayexalate resin and calcium polystyreme sulphonate resin medicine and domestic open (bulletin) number CN1857302 of treatment hyperpotassemia can be used as and treat the hyperphosphatemia Poly(lanthanum styrenesulfonate). and carry out ion exchange by human body alimentary canal and also absorb ferrum, thereby suppressed absorption by the ferrum of intestinal, make in the blood, concentration of iron and leucocrit value in the tissue reduce, thereby make the aggravation of dialysis patient iron deficiency anemia.Equally, put down in writing in the international open WO94/27621 communique by means of containing the next method of amino polymer in conjunction with iron ion, amino polystyrene type and acrylic resin are arranged as if the former state administration, also occur the probability of above-mentioned side effect (iron deficiency anemia).
Summary of the invention
The present invention is directed to the deficiencies in the prior art, a kind of treatment chronic renal failure patients's hyperphosphatemia and exsanguine medicine are provided, the present invention also provides the preparation method of this medicine.
Summary of the invention
It is the active ingredient of medicine that the present invention adopts with the ferrous resin of polystyrolsulfon acid, suitable in addition pharmaceutic adjuvant or do not add medicinal adjuvant and make medicament, through gastrointestinal administration, phosphate in active ingredient of the present invention and patient's the digestive tract is combined into insoluble material, excrete through digestive tract, thereby reduce the intravital phosphate of chronic kidney hypofunction patient, reach the purpose of treatment hyperphosphatemia.In ferrous resin of medicine polystyrolsulfon acid of the present invention and bonded while of phosphate, the ferrous ion of the ferrous resin remainder of polystyrolsulfon acid dissociates, be absorbed by the body, replenished intravital iron ion, played the purpose of treatment chronic renal failure patients iron deficiency anemia.Said medicine also can be used for the preventive as treatment of chronic renal failure patients's hyperphosphatemia and iron deficiency anemia.
Detailed Description Of The Invention
Technical scheme of the present invention is as follows:
A kind of medicine for the treatment of hyperphosphatemia and iron deficiency anemia is characterized in that, the medicine active ingredient is the ferrous resin of polystyrolsulfon acid, and the polymerized unit structural formula is as follows:
The ferrous resin mean molecule quantity of described polystyrolsulfon acid is 3,000-1,000,000.
The percentage by weight of the ferrous resin of described polystyrolsulfon acid in medicine is 20-100%.Further preferred, the percentage by weight of the ferrous resin of polystyrolsulfon acid in medicine is 70-100%.
The weight of ferrous ion is 3.8%-5.1% in the ferrous resin of described polystyrolsulfon acid, and further preferred, the weight of ferrous ion is 4.0%-5.0% in the ferrous resin of described polystyrolsulfon acid.
Pharmaceutical dosage form of the present invention is powder, capsule, tablet, dry suspension, suspensoid or granule.
The preparation method of the above-mentioned treatment hyperphosphatemia and the medicine of iron deficiency anemia, step is as follows:
Get the poly styrene sulfonate resin with hcl acidifying handle obtain polystyrene sulfonic acid resin after reuse water solublity ferrous salt solution soak or eluting, it is neutral washing with water to pH value, till will not exchanging unnecessary ferrous ion again and cleaning, be ground into powdery after taking out the ferrous resin drying of polystyrolsulfon acid, the ferrous weight in the ferrous resin-oatmeal of gained polystyrolsulfon acid is 3.8%-5.1%.
Wherein, described poly styrene sulfonate resin can be selected from kayexalate resin, calcium polystyreme sulphonate resin, polystyrolsulfon acid potassium resin or polystyrolsulfon acid magnesium resin, consider commercial production manufacturing cost aspect, further preferred kayexalate resin or calcium polystyreme sulphonate resin.
Described poly styrene sulfonate resin is handled with hcl acidifying and is obtained behind the polystyrene sulfonic acid resin that reuse water solublity ferrous salt solution soaks or eluting is under 0 ℃ of-60 ℃ of temperature, places and soaks 5-72 hour or eluting 5-72 hour.Further preferred, above-mentioned immersion of water solublity ferrous salt solution or the eluting temperature used placed and soaked 24-48 hour or eluting 24-48 hour at 20-50 ℃.The time of placing immersion or eluting is relevant with the concentration of water solublity ferrous salt, can soak according to the concentration adjustment of soluble-salt and place or elution time.
The water solublity ferrous salt solution is Ferrous acetate, Ferrous gluconate, ferrous fumarate, ferrous citrate, ferrous chloride or ferrous sulfate in the described preparation method.Water solublity ferrous salt solution concentration 8-15%wt is good.
The ferrous resin-oatmeal of the polystyrolsulfon acid of gained is medicinal active ingredient, can not add medicinal adjuvant directly as powder.
The ferrous resin-oatmeal of the polystyrolsulfon acid of gained is medicinal active ingredient, adds the pharmaceutic adjuvant of convention amount and makes powder, capsule, tablet, dry suspension, suspensoid or granule.Described pharmaceutic adjuvant be in the field of medicaments employed any one.
In the said method of the present invention, also can be with the poly styrene sulfonate resin at reuse soak with ethanol eluting poly styrene sulfonate resin behind water logging bubble eluting and further remove impurity, also can carry out behind the ferrous resin of polystyrolsulfon acid obtaining with ethanol elution.
The weight of the ferrous ion in the ferrous resin of the polystyrolsulfon acid that said method of the present invention obtains can be controlled in 3.8%-5.1%, is preferably 4.0%-5.0%.Institute's water is a deionized water in the preparation method of the present invention.
The ferrous resin medicine of polystyrolsulfon acid of the present invention all has the effect of good dephosphorization hydrochlorate in stomach, small intestinal, large intestine and the whole digestive tract of human body, the ferrous resin of polystyrolsulfon acid combines the insoluble material of formation and excretes with intravital phosphate, remaining ferrous ion is absorbed by digestive tract, plays the effect of treatment iron deficiency anemia.
In order further to show the dephosphorization hydrochlorate effect of the ferrous resin medicine of polystyrolsulfon acid in human body alimentary canal, prepare simulated gastric fluid, intestinal fluid, big intestinal juice respectively, test as follows:
Testing liquid 1: get Na
2HPO
414g, NaCL, 8.5g are dissolved in the 1000ml distilled water, transfer PH to 3 with hydrochloric acid, filter, and measure phosphatic content.
Testing liquid 2: get Na
2HPO
414g, NaCL, 8.5g are dissolved in the 1000ml distilled water, transfer PH to 6.8 with hydrochloric acid, filter, and measure phosphatic content.
Testing liquid 3: get Na
2HPO
414g, NaCL, 8.5g are dissolved in the 1000ml distilled water, transfer PH to 7.8 with hydrochloric acid, filter, and measure phosphatic content.
Get testing liquid 1,2,3, add the ferrous resin of quantitative polystyrolsulfon acid respectively, be that ferrous ion and phosphatic mol ratio are 3: 1, under 37 ℃ of conditions, fully stir, get certain testing liquid every the regular hour, measure its phosphatic content, calculate removed phosphatic percentage ratio in the testing liquid.Result of the test sees Table 1:
The phosphate statistical table is removed by table 1 testing liquid
| Time (minute) | Remove phosphate (%) | ||
| Testing liquid 1 | Testing liquid 2 | Testing liquid 3 | |
| 10 | 92.5 | 94.2 | 93.2 |
| 20 | 93.3 | 95.1 | 94.3 |
| 30 | 94.8 | 97.1 | 94.8 |
| 60 | 95.6 | 97.5 | 95.9 |
Analyze from table 1 result of the test and reach a conclusion: the ferrous resin of polystyrolsulfon acid is removed phosphatic effect in simulated gastric fluid, intestinal fluid, big intestinal juice better.
In the preparation method of the present invention, prepare the yield height of the ferrous resin of polystyrolsulfon acid, in the quantitative condition of water solublity ferrous salt, the poly styrene sulfonate resin is relevant with water solublity ferrous salt reaction temperature and time, ferrous many more in the ferrous resin of polyvinyl sulfonic acid of long more preparation of time, promptly yield is then high more; Otherwise then few more, promptly yield is low more.Temperature is high more, and the ferrous resin of the polyvinyl sulfonic acid for preparing Central Asia iron phase should be more, and promptly yield is high more; Otherwise then few, promptly yield is low more, preparation test data such as table 2, table 3:
1,2,3,4 is poly styrene sulfonate resin and Ferrous acetate 1: 3 (weight ratio) in the table 2, the ferrous resin of the polyvinyl sulfonic acid that under different condition, obtains, and different time is prepared according to the method described in the present invention, and result of the test sees Table 2.
The ferrous resin different time of table 2 preparation polystyrolsulfon acid relatively
| Sample | Temperature (℃) | Time (h) | Ferrous weight (%) in the ferrous resin of polystyrolsulfon acid |
| 1 | 20 | 72 | 4.8 |
| 2 | 20 | 60 | 4.2 |
| 3 | 20 | 48 | 3.9 |
| 4 | 20 | 36 | 3.8 |
1,2,3,4 is poly styrene sulfonate resin and Ferrous gluconate 1: 3 (weight ratio) in the table 3, the ferrous resin of the polystyrolsulfon acid that under different condition, obtains, and different temperatures is prepared according to the method described in the present invention, and result of the test sees the following form 3:
The ferrous resin different temperatures of table 3 preparation polystyrolsulfon acid relatively
| Sample | Temperature (℃) | Time (h) | Ferrous weight (%) in the ferrous resin of polystyrolsulfon acid |
| 1 | 50 | 48 | 5.1 |
| 2 | 40 | 48 | 4.7 |
| 3 | 30 | 48 | 4.2 |
| 4 | 20 | 48 | 3.9 |
The preparation temperature of being explained in above-mentioned table 2, the table 3 can be 0-60 ℃, then needs corresponding prolongation because temperature is got over the low reaction time, and is unfavorable for suitability for industrialized production, and therefore general employing is good for 20-50 ℃.
Pharmacodynamics test of the present invention is as follows:
The ferrous resin of polystyrolsulfon acid is tested as follows to the therapeutical effect of chronic kidney hypofunction (CRF) hyperphosphatemia:
Be subjected to the reagent thing:
The ferrous resin of polystyrolsulfon acid; 6～8 all SD rats, body weight 190-200g, 30 of quantity, random packet: 1. the normal control group is 10, continues to use forage feed, and irritate stomach with the 2ml/200g tap water every day after 2 weeks; 2. model control group is 10, irritates stomach for 0.5% adenine 2ml/200g; 3. 10 of treatment groups irritate stomach for 0.5% adenine 2ml/200g, and irritate equal 6 weeks of continuous irrigation stomach of the above animal of the ferrous resin 300mg/kg. of stomach polystyrolsulfon acid every day after 2 weeks, and the 6th week took a blood sample from rat, detected serium inorganic phosphorus (P) result of the test respectively and saw the following form 4:
Table 4 chronic kidney hypofunction hyperphosphatemia result of the test
| Group | Number of elements | 6 all P (mol/L) |
| The normal control group | 10 | 2.62±0.28 |
| Model control group | 10 | 5.12±0.34 |
| The treatment group | 10 | 3.12±0.21 |
Model control group and 6 weeks of normal control group are than (p＜0.05); With treatment group and 6 weeks of model control group than (p＜0.05).
Conclusion: the ferrous resin of polystyrolsulfon acid can reduce the serium inorganic phosphorus of hyperphosphatemia rat.
The ferrous resin of polystyrolsulfon acid is as follows to the pharmacodynamics test of treatment for anemia effect due to the chronic kidney hypofunction;
Be subjected to the reagent thing: the ferrous resin of polystyrolsulfon acid; Get healthy male rat body weight 190～200g, 30 of quantity, random packet: 1. the normal control group is 10, continues to use forage feed, and irritate stomach with the 2ml/200g tap water every day after 2 weeks; 2. model control group is 10, irritates stomach for 0.5% adenine 2ml/200g; 3. 10 of treatment groups, irritate stomach for 0.5% adenine 2ml/200g, irritate equal 6 weeks of continuous irrigation stomach of the above animal of the ferrous resin 300mg/kg. of stomach polystyrolsulfon acid every day after 2 weeks, and the 6th week took a blood sample from rat, animal RBC, HB, HCT, EPO, SP, ALB are tried respectively to survey, the results are shown in following table 5, table 6;
Table 5 chronic kidney hypofunction anemia RBC, HB, HCT result of the test
| Group | Number of elements | RBC(10 10) | HB(g/l) | HCT(％) |
| The normal control group | 10 | 6.30±0.52 | 123.5±8.4 | 39.7±3.2 |
| Model control group | 6 | 5.50±0.26 | 95.0±5.0 | 35.5±1.85 |
| The treatment group | 8 | 6.10±0.50 | 112.0±7.0 | 39.5±3.3 |
Table 6 chronic kidney hypofunction anemia EPO, SP, ALB result of the test
| Group | Number of elements | EPO(mu/ml) | SP(g/l) | ALB(g/l) |
| The normal control group | 10 | 9.10±0.69 | 78.55±0.71 | 40.85±2.19 |
| Model control group | 6 | 5.75±1.9 | 64.85±3.58 | 32.05±1.63 |
| The treatment group | 8 | 7.23±0.58 | 72.50±1.68 | 35.30±1.47 |
Conclusion: the ferrous resin of polystyrolsulfon acid descends to the rat chronic renal failure anemia model RBC due to the adenine, HB, HCT to a certain degree improvement, and difference has statistical significance, and EPO, SP, ALB are also had to a certain degree improvement.
Above-mentioned table 4, table 5, table 6 test data show: the ferrous resin of polystyrolsulfon acid can be removed the phosphate in stomach, small intestinal, the large intestine, form insoluble conjugate with the phosphate in the digestive tract, and excrete, thereby reach the purpose of treatment hyperphosphatemia with gastral wriggling.Because the ferrous resin of polystyrolsulfon acid is because of intravital phosphatic minimizing, ferrous ion discharges and is absorbed by the body, so play the effect of treatment iron deficiency anemia again.
The medicines such as powder, granule, capsule, dry suspension, suspensoid or tablet that ferrous resin of polystyrolsulfon acid of the present invention and the adjuvant that suits and preparation method of the present invention are made, the relatively lower financial burden that can reduce the patient of its preparation cost obtains good social benefit.
Wherein, the weight of the ferrous ion in the ferrous resin of polystyrolsulfon acid of the present invention is generally 3.8-5.1%, also can be lower than 4.0%, need to increase oral drug dose owing to be lower than 4.0%, the ferrous ion weight that the present invention has further optimized in the ferrous resin of polystyrolsulfon acid is 4.0-5.0%.
Pharmaceutical dosage form of the present invention is powder, granule, capsule, dry suspension, suspensoid or tablet etc.As to get the weight that contains ferrous ion in the ferrous resin of polystyrolsulfon acid be that the powder of the ferrous resin of polystyrolsulfon acid of 3.8%, 4.2%, 4.4%, 4.6%, 4.8%, 5.0% arbitrary weight adds the pharmaceutic adjuvant mix homogeneously routinely and makes powder.Or do not add adjuvant and directly obtain powder with the ferrous resin powder of polystyrolsulfon acid.Can be used for coloclysis, or make dry suspension according to the amount mix homogeneously of conventional pharmaceutic adjuvant, or according to the amount adding of conventional pharmaceutic adjuvant and the suspension of water mix homogeneously system; Or make pack into conventional capsule or enteric coated capsule of granule with suitable adjuvant according to the amount of conventional pharmaceutic adjuvant and suitable wetting agent and obtain capsule or obtain tablet with the granule direct compression that obtains.
Pharmaceutic adjuvant of the present invention be with in the pharmaceutical field employed any one.
Drug oral with the ferrous resins of polystyrolsulfon acid of the present invention can be treated hyperphosphatemia and iron deficiency anemia symptom through gastrointestinal administration.
Evidence of the present invention: the ferrous resin of polystyrolsulfon acid can be in the application of any medicine of the medicine of the iron deficiency anemia that causes thus by gastrointestinal administration treatment hyperphosphatemia and dialysis patient.The Coming-of-Age Day of medicine of the present invention oral consumption to be calculated as 4.0-9.0g with the weight of the ferrous resin of polystyrolsulfon acid serve as easy.The patient of child or special body constitution can follow the doctor's advice according to circumstances.
The specific embodiment
The present invention will be further described below in conjunction with embodiment, but be not limited thereto.Wherein, used water solublity ferrous salt solution concentration all is weight percentage.Used kayexalate resin is 001 * 7 resin.
1. 1 kinds of medicines for the treatment of hyperphosphatemia and iron deficiency anemia of embodiment, medicine active ingredient are the ferrous resin of polystyrolsulfon acid, mean molecule quantity 3000-10000, and the polymerized unit structural formula is as follows:
Preparation method is as follows:
Get kayexalate resin 50 grams, with hcl acidifying handle obtain polystyrene sulfonic acid resin after, 2000 milliliters of immersions of the Ferrous acetate with 8% keep 50 ℃ of placements of temperature 8 hours, closely neutral with no ionic water washing to pH, continue washing till unnecessary ferrous ion is cleaned.Take out the ferrous resin drying of polystyrolsulfon acid, pulverizing.Obtain the ferrous resin of powdered polystyrolsulfon acid, ferrous weight is 4.7% in the ferrous resin of polystyrolsulfon acid after testing.The ferrous resin-oatmeal of this polystyrolsulfon acid can directly use as powder.
2. 1 kinds of medicines for the treatment of hyperphosphatemia and iron deficiency anemia of embodiment, medicine active ingredient are the ferrous resin of polystyrolsulfon acid, and the percentage by weight of the ferrous resin of polystyrolsulfon acid in medicine is 95%wt, and preparation method is as follows:
Get calcium polystyreme sulphonate resin 50 grams, with hcl acidifying handle obtain polystyrene sulfonic acid resin after, 2000 milliliters of immersions of Ferrous gluconate with 15%, keep temperature to place 20 hours for 20 ℃, closely neutral with no ionic water washing to pH, continue washing till unnecessary ferrous ion is cleaned.Take out the ferrous resin drying of polystyrolsulfon acid, pulverizing.Obtain the ferrous resin of powdered polystyrolsulfon acid, ferrous weight is 3.82% in the ferrous resin of polystyrolsulfon acid after testing.Get the ferrous resin-oatmeal of polystyrolsulfon acid, make pack into conventional capsule or enteric coated capsule of granule according to the amount of conventional pharmaceutic adjuvant and suitable wetting agent and obtain capsule, concrete grammar is made by the existing routine techniques in this area.
3. 1 kinds of medicines for the treatment of hyperphosphatemia and iron deficiency anemia of embodiment, medicine active ingredient are the ferrous resin of polystyrolsulfon acid, and the percentage by weight of the ferrous resin of polystyrolsulfon acid in medicine is 85%wt, and preparation method is as follows:
Get kayexalate resin 50 gram, with hcl acidifying handle obtain polystyrene sulfonic acid resin after, wet method dress post keeps 60 ℃ of column temperatures, 2000 milliliters of eluting of the Ferrous acetate with 10%, elution time 4 hours, or eluting 2-3 time; Closely neutral with no ionic water washing to pH, continue washing till unnecessary ferrous ion is cleaned.Take out the ferrous resin drying of polystyrolsulfon acid, pulverizing.Obtain the ferrous resin of powdered polystyrolsulfon acid, ferrous weight is 4.6% in the ferrous resin of polystyrolsulfon acid after testing.Get the ferrous resin of polystyrolsulfon acid, make granule according to the amount of conventional pharmaceutic adjuvant and suitable wetting agent, tabletting obtains tablet again.Concrete grammar is made by the existing routine techniques in this area.
4. 1 kinds of medicines for the treatment of hyperphosphatemia and iron deficiency anemia of embodiment, medicine active ingredient are the ferrous resin of polystyrolsulfon acid, and the percentage by weight of the ferrous resin of polystyrolsulfon acid in medicine is 90%wt, and preparation method is as follows:
Get kayexalate resin 50 grams with behind the distilled water immersion, and with deionized water flushing to clarification, the reuse medicinal alcohol soaks removes impurity, with hcl acidifying handle obtain polystyrene sulfonic acid resin after, 2000 milliliters of immersions of ferrous sulfate with 10%, keep temperature to place 8 hours for 30 ℃, wash to pH closely neutrally with deionized water, continue washing till will unnecessary ferrous ion clean.Take out the ferrous resin drying of polystyrolsulfon acid, pulverizing.Obtain the ferrous resin of powdered polystyrolsulfon acid, ferrous weight is 4.2% in the ferrous resin of polystyrolsulfon acid after testing.Get the ferrous resin of polystyrolsulfon acid, make dry suspension according to the amount mix homogeneously of conventional pharmaceutic adjuvant.Concrete grammar is made by the existing routine techniques in this area.
5. 1 kinds of medicines for the treatment of hyperphosphatemia and iron deficiency anemia of embodiment, medicine active ingredient are the ferrous resin of polystyrolsulfon acid, and the percentage by weight of the ferrous resin of polystyrolsulfon acid in medicine is 25%wt, and preparation method is as follows:
Getting kayexalate resin 50 restrains with after the deionized water immersion, and with deionized water flushing to clarification, the reuse medicinal alcohol soaks removes impurity, with hcl acidifying handle obtain polystyrene sulfonic acid resin after, wet method dress post keeps 50 ℃ of column temperatures, 2000 milliliters of eluting of the ferrous chloride with 10%, eluting does not wait for 1 time, 2 times or 3 times, and elution time is 16 hours; The reuse deionized water washs to pH closely neutral, continues washing till unnecessary ferrous ion is cleaned.Take out the ferrous resin drying of polystyrolsulfon acid, pulverizing.Obtain the ferrous resin of powdered polystyrolsulfon acid, ferrous weight is 4.9% in the ferrous resin of polystyrolsulfon acid after testing.Get the ferrous resin of polystyrolsulfon acid, make suspension according to convention amount adding pharmaceutic adjuvant and water mix homogeneously.Concrete grammar is made by the existing routine techniques in this area.
6. 1 kinds of medicines for the treatment of hyperphosphatemia and iron deficiency anemia of embodiment, medicine active ingredient are the ferrous resin of polystyrolsulfon acid, and the percentage by weight of the ferrous resin of polystyrolsulfon acid in medicine is 97%wt, and preparation method is as follows:
Getting kayexalate resin 50 restrains with after the deionized water immersion, and with deionized water flushing to clarification, the reuse medicinal alcohol soaks removes impurity, with hcl acidifying handle obtain polystyrene sulfonic acid resin after, 2000 milliliters of immersions of ferrous fumarate with 10%, keep temperature to place 72 hours for 20 ℃, wash to pH closely neutrally with deionized water, continue washing till will unnecessary ferrous ion clean.Take out the ferrous resin drying of polystyrolsulfon acid, pulverizing.Obtain the ferrous resin of powdered polystyrolsulfon acid, ferrous weight is 5.0% in the ferrous resin of polystyrolsulfon acid after testing.Get the ferrous resin of polystyrolsulfon acid, add powdery pharmaceutical adjuvant mix homogeneously and make dry suspension.
7. 1 kinds of medicines for the treatment of hyperphosphatemia and iron deficiency anemia of embodiment, medicine active ingredient are the ferrous resin of polystyrolsulfon acid, and the percentage by weight of the ferrous resin of polystyrolsulfon acid in medicine is 50%wt, and preparation method is as follows:
Getting kayexalate resin 50 restrains with after the deionized water immersion, and with deionized water flushing to clarification, the reuse medicinal alcohol soaks removed impurity in 8 hours, with hcl acidifying handle obtain polystyrene sulfonic acid resin after, 2000 milliliters of branches of Ferrous acetate with 10% soak for 3 times, keep temperature to place 8 hours for 35 ℃, be washed till pH neutrality with deionized water preceding 2 times, the 3rd washing is till will unnecessary ferrous ion clean.Take out the ferrous resin drying of polystyrolsulfon acid, pulverizing.Obtain the ferrous resin of powdered polystyrolsulfon acid, ferrous weight is 3.9% in the ferrous resin of polystyrolsulfon acid after testing.Get the ferrous resin of polystyrolsulfon acid, make medicament according to the preparation method of preparation of the present invention.
8. 1 kinds of medicines for the treatment of hyperphosphatemia and iron deficiency anemia of embodiment, medicine active ingredient are the ferrous resin of polystyrolsulfon acid, and the percentage by weight of the ferrous resin of polystyrolsulfon acid in medicine is 60%wt, and preparation method is as follows:
Getting kayexalate resin 50 restrains with after the deionized water immersion, and with deionized water flushing to clarification, the reuse medicinal alcohol soaks removed impurity in 8 hours, with hcl acidifying handle obtain polystyrene sulfonic acid resin after, 2000 milliliters of branches of ferrous citrate with 10% soak for 2 times, keep temperature to place 16 hours for 20 ℃, be washed till pH neutrality with deionized water for the first time, back deionized water washing is till cleaning unnecessary ferrous ion.Take out the ferrous resin drying of polystyrolsulfon acid, pulverizing.Obtain the ferrous resin of powdered polystyrolsulfon acid, ferrous weight is 4.7% in the ferrous resin of polystyrolsulfon acid after testing.Get the ferrous resin of polystyrolsulfon acid, make medicament according to the preparation method of preparation of the present invention.
Claims (10)
1. a medicine for the treatment of hyperphosphatemia and iron deficiency anemia is characterized in that the medicine active ingredient is the ferrous resin of polystyrolsulfon acid, and the polymerized unit structural formula is as follows:
2. the medicine of treatment hyperphosphatemia according to claim 1 and iron deficiency anemia is characterized in that: the ferrous resin mean molecule quantity of polystyrolsulfon acid is 3,000-1,000,000, the percentage by weight in medicine is 20-100%, preferred 70-100%.
3. the medicine of treatment hyperphosphatemia according to claim 2 and iron deficiency anemia is characterized in that: ferrous content percentage by weight is 3.8%-5.1% in the ferrous resin of described polystyrolsulfon acid.
4. the medicine of treatment hyperphosphatemia according to claim 2 and iron deficiency anemia is characterized in that: ferrous content percentage by weight is 4.0%-5.0% in the ferrous resin of polystyrolsulfon acid.
5. the medicine of claim 1,2,3 or 4 described treatment hyperphosphatemias and iron deficiency anemia, it is characterized in that: described pharmaceutical dosage form is powder, capsule, tablet, dry suspension, suspensoid or granule.
6. the preparation method of the medicine of described treatment hyperphosphatemia of claim 1 and iron deficiency anemia, it is characterized in that: get the poly styrene sulfonate resin with hcl acidifying handle obtain polystyrene sulfonic acid resin after reuse water solublity ferrous salt solution soak or eluting, it is neutral washing with water to pH value, till will not exchanging unnecessary ferrous ion again and cleaning, be ground into powdery after taking out the ferrous resin drying of polystyrolsulfon acid, ferrous weight in the ferrous resin of gained polystyrolsulfon acid is 3.8%-5.1%, with the ferrous resin-oatmeal of the polystyrolsulfon acid of gained is medicinal active ingredient, adds the pharmaceutic adjuvant of convention amount and makes medicament.
7. the preparation method of the medicine of treatment hyperphosphatemia according to claim 6 and iron deficiency anemia, it is characterized in that: described poly styrene sulfonate resin is handled with hcl acidifying and is obtained behind the polystyrene sulfonic acid resin that reuse water solublity ferrous salt solution soaks or eluting is under 0 ℃ of-60 ℃ of temperature, places and soaks or eluting 5-72 hour.
8. according to the process for preparing medicine of claim 6 or 7 described treatment hyperphosphatemias and iron deficiency anemia, it is characterized in that: described water solublity ferrous salt solution is Ferrous acetate, Ferrous gluconate, ferrous fumarate, ferrous citrate, ferrous chloride or copperas solution, water solublity ferrous salt solution concentration 8-15%wt.
9. the preparation method of the medicine of treatment hyperphosphatemia according to claim 6 and iron deficiency anemia is characterized in that: described pharmaceutical dosage form is powder, capsule, tablet, dry suspension, suspensoid or granule.
10. the medicine of claim 1 or 2 or 3 or 4 or 5 any described treatment hyperphosphatemias and iron deficiency anemia is crossed application in disease and the anemia medicine in preparation through intestines and stomach drug treatment serium inorganic phosphorus hydrochlorate.
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| CN200710112949A CN100574765C (en) | 2007-09-19 | 2007-09-19 | A kind of medicine for the treatment of hyperphosphatemia and iron deficiency anemia |
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| CN200710112949A CN100574765C (en) | 2007-09-19 | 2007-09-19 | A kind of medicine for the treatment of hyperphosphatemia and iron deficiency anemia |
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| CN100574765C CN100574765C (en) | 2009-12-30 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103536977A (en) * | 2013-11-04 | 2014-01-29 | 于杰 | Hemoperfusion apparatus |
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| JP5054259B2 (en) * | 2001-01-25 | 2012-10-24 | 出光興産株式会社 | Flame retardant polycarbonate resin composition and molded product thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103536977A (en) * | 2013-11-04 | 2014-01-29 | 于杰 | Hemoperfusion apparatus |
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| CN100574765C (en) | 2009-12-30 |
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Owner name: GUANGDONG BANGMIN PHARMACEUTICAL FACTORY CO., LTD. Free format text: FORMER OWNER: LIU GANG Effective date: 20091218 |
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Effective date of registration: 20091218 Address after: No. 33, min Lu, hi tech Development Zone, Guangdong, Jiangmen Patentee after: Guangdong Bangmin Pharmaceutical Co., Ltd. Address before: No. 45, Shandong Road, thousand Buddha, Lixia District, Ji'nan, Shandong Patentee before: Liu Gang |