CN101152458A - Traditional Chinese medicine preparation for treating cerebral apoplexy sequela - Google Patents

Traditional Chinese medicine preparation for treating cerebral apoplexy sequela Download PDF

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Publication number
CN101152458A
CN101152458A CNA2007100188449A CN200710018844A CN101152458A CN 101152458 A CN101152458 A CN 101152458A CN A2007100188449 A CNA2007100188449 A CN A2007100188449A CN 200710018844 A CN200710018844 A CN 200710018844A CN 101152458 A CN101152458 A CN 101152458A
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rhizoma
radix
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chinese medicine
fructus
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CN101152458B (en
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郭淑梅
付传周
吕行
谢晓芸
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Abstract

The present invention belongs to a Chinese traditional medicine preparation in medical preparation product for curing sequela of cerebral paralysis; the preparation is made of the following raw materials of Chinese traditional medicines with corresponding weight portions of 6 portion to 12 portion of zhinanxing, 6 portion to 12 portion of pinellia tuber, 4 portion to 8 portion of giant typhonium tuber, 10 portion to 20 portion of chuanxiong rhizome, 6 portion to 12 portion of body of Buthus martensii, 15 portion to 25 portion of earthworm, 10 portion to 20 portion of tall gastrodia tuber, 15 portion to 25 portion of clematis, 10 portion to 20 portion of white caltrop, 40 portion to 60 portion of milk vetch roots, 10 portion to 20 portion of magnolia officinalis, 15 portion to 25 portion of trifoliate orange fruit, 15 portion to 25 portion of roots of red salvia, 10 portion to 20 portion of flagleaf, 15 portion to 25 portion of Tuckahoe, 15 portion to 25 portion of milkwort roots, 15 portion to 25 portion of codonopsis pilosula, 5 portion to 7 portion of safflowers, 10 portion to 20 portion of ledeboruiella root, 10 portion to 20 portion of myrrh, 7 portion to 11 portion of gynura segetum and 15 portion to 20 portion of sapanwood. The present invention of the preparation contains active components which can stimulate the impaired brain cells and recover the function of the cells through blood-brain barrier; at the same time, the preparation can repair the impaired nerves and recover the impaired blood-brain barrier to protect the brain tissue and improve the nerve function of patients; the preparation can promote the absorption of encephalic hematoma and reduce the disability rate; in this way, people can recover normal living and working capability and the present invention is a good medicine for curing sequela of cerebral paralysis.

Description

A kind of Chinese medicine preparation for the treatment of the apoplexy sequela
Technical field
The invention belongs to the pharmaceutical product technical field, particularly a kind of Chinese medicine preparation for the treatment of the apoplexy sequela.
Background technology
It serves as the disease of main performance with brain ischemia and hemorrhagic damage symptom that apoplexy is one group, claim apoplexy or cerebrovascular accident again, because of this class disease onset hurried, break with tremendous force, change of illness state is rapid, as natural wind " change of benefaction number ", " changing unpredictably ", the ancient medicine analogy and the name its be " apoplexy ".This type of disease has high case fatality rate and disability rate, and weight person's threat to life often stays sequela.The patient often leaves over obstacles such as some motions, sensation and language after surviving through hospital's treatment, and convalescent period is long, and the treatment for sequela after therefore leaving hospital becomes a difficult problem.
Common sequela rehabilitation maneuver comprises:
1. three is inclined to one side: lose of apoplexy has dysfunctions such as hemiplegia, hemidysesthesia (referring to the half side pain sensation of patient, thermo aesthesia and proprioceptive sensation obstacle), hemianopsia more.Because apoplexy causes that limb function is movable to be reduced, the part articular muscle is in uselessly use state, so Most patients is disinclined to activity, therefore, the mode of crumpling limbs of massaging commonly used promotes rehabilitation.
2. dysphonia: stroke patient bradyphrenia more than half, association's difficulty is though hypomnesis, not sociable or babble Chu or can spontaneously speak give an irrelevant answer and do not understand the meaning that others speaks etc.These all be in wind-induced sequela, the many anxieties of patient's emotion, misery.Function rehabilitation training comprises the training of pronunciation training, phrase, session training, reads aloud training, the sentence training of rehearsing, text-recognition, point out that Item Title, fill order and picture, pairing in kind are practised etc.
3. distortion of commissure, dysphagia: Ipsilateral hypophasis, ptosis of labial angle, sialorrhea, can not rouse the cheek, wrinkle volume, close one's eyes.
Other: patient's long-term bed is prone to decubital ulcer, pulmonary infection, urinary system infection and venous thrombosis.
Mainly pay attention to nursing for the rehabilitation of apoplexy sequela at present, then do not have good medicine for treatment.
Summary of the invention
The object of the invention provides a kind of medicine that helps the apoplexy sequela rehabilitation.
Specifically, a kind of Chinese medicine preparation for the treatment of the apoplexy sequela, make by following weight portion raw material of Chinese medicine:
Rhizoma Arisaematis (processed) 6-12, Rhizoma Pinelliae 6-12, Rhizoma Typhonii 4-8, Rhizoma Chuanxiong 10-20,
Scolopendra 6-12, Scorpio 6-12, Pheretima 15-25, Rhizoma Gastrodiae 10-20,
Caulis Akebiae 15-25, Fructus Atriplicis Sibiricae 10-20, Radix Astragali 40-60 Cortex Magnoliae Officinalis 10-20,
Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 15-25, Radix Salviae Miltiorrhizae 15-25, Rhizoma Acori Graminei 10-20, Poria 15-25,
Radix Polygalae 15-25, Radix Codonopsis 15-25, Flos Carthami 5-7, Radix Saposhnikoviae 10-20,
Myrrha 10-20, Radix Notoginseng 7-11 Lignum Sappan 15-25.
Preferential each the set of dispense ratio recommended of the present invention is:
Rhizoma Arisaematis (processed) 9 Rhizoma Pinelliaes 9 Rhizoma Typhoniis 6 Rhizoma Chuanxiongs 15 Scolopendras 9 Scorpios 9
Pheretima 20, Rhizoma Gastrodiae 15 Caulis Akebiaes 20 Fructus Atriplicis Sibiricaees 15 Radixs Astragali 50 Cortex Magnoliae Officinalis 15
Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 20 Radix Salviae Miltiorrhizaes 20 Rhizoma Acori Gramineis 15 Poria 20 Radix Polygalaes 20 Radix Codonopsis 20
Flos Carthami 6 Radix Saposhnikoviaes 15 Myrrhas 15 Radix Notoginseng 9 Lignum Sappans 20.
Each component effect is among the present invention:
Rhizoma Arisaematis (processed)-removing dampness and eliminating phlegm, expelling wind to relieve convulsion, toxin expelling doctor skin ulcer.
The Rhizoma Pinelliae-removing dampness and eliminating phlegm, stopping nausea and vomiting by lowering the adverse flow of QI.
Rhizoma Typhonii-dispelling phlegm and alleviating pain is expellingged wind and relieving convulsion, removing dampness to relieve itching.
Rhizoma Chuanxiong-blood-activating and qi-promoting, wind-expelling pain-stopping.
Scolopendra-relieving spasm by subduing liver-wind, toxin expelling is treated skin ulcer.
Scorpio-relieving spasm by subduing liver-wind, active straight-through, toxin expelling is treated skin ulcer.
Pheretima-heat clearing away relieving convulsion, collateral dredging is treated numbness, and liver heat removing is relievingd asthma, inducing diuresis for treating stranguria syndrome.
Rhizoma Gastrodiae-relieving spasm by subduing liver-wind, removing obstruction in the collateral to relieve pain.
Caulis Akebiae-pathogenic fire reducing diuresis, a surname's promoting blood circulation.
Fructus Atriplicis Sibiricae-dispel the wind is soothing the liver, promoting flow of QI and blood.
The Radix Astragali-tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, holder common people flesh, inducing diuresis to remove edema.
Cortex Magnoliae Officinalis-circulation of qi promoting removing dampness, warming middle-JIAO to relieve pain, lowering the adverse QI to relieve asthma.
Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus)-promoting the circulation of QI to relieve pain, the heat clearing away toxin expelling.
Radix Salviae Miltiorrhizae-activating blood and removing stasis, relieving restlessness is calmed the nerves, reducing swelling and alleviating pain.
Rhizoma Acori Graminei-the expectorant of having one's ideas straightened out, refreshment brain-strengthening, removing dampness appetizing.
Poria-dampness removing toxin expelling.
Radix Polygalae-tranquilizing by nourishing the heart, expelling phlegm for arresting cough.
Radix Codonopsis-invigorating the spleen and replenishing QI, nourishing blood to promote the production of body fluid.
Flos Carthami-promoting blood circulation to restore menstrual flow, stasis-dispelling and pain-killing.
Radix Saposhnikoviae-wind row the table that looses, removing dampness to relieve pain is expellingged wind and relieving convulsion.
Myrrha-promoting blood circulation and stopping pain, detumescence and promoting granulation.
Radix Notoginseng-hemostasia and dissipation blood stasis, subduing swelling and relieving pain.
Lignum Sappan-blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain.
Treatment mechanism of the present invention and beneficial effect: according to Traditional Chinese medical theory, in conjunction with modern pharmacology and clinical research, the main pathogenesis that forms at apoplexy is that positive wind-transformation is moving, bleeding resulting from adverse flow of QI, on hold together that key, key clearly close that god hides, the characteristics of refreshing not inducing QI, venation block, utilize the characteristic of meridians qi and blood circulation promotion on the one hand, " consciousness-restoring and orifice-opening composition " led people's " governor vessel " and " meridian of Foot-TAI YANG " automatically, follow through and on, through brain focal zone, improve the biochemical environment of focal zone, develop compensatory blood vessel.On the other hand, medicine enters blood, under the inducing of meridians, accelerates thromboembolism speed, effectively improves hemorheology index, reduces blood viscosity, increases cerebral blood supply, and the injured nerve brain cell is repaired.Medicine after absorbing, can go directly rapidly cerebrovascular, not normal limbs and face nerve system, mediation infraction blood vessel, the absorption of promotion cephalophyma and cerebral edema, set up effective side limb circulation, improve blood vessel elasticity and arteriosclerosis, improve blood viscosity and microcirculation, be beneficial to the brain metabolism.Suppressing the hyperactive liver to relieve the wind syndrome, mediation are set upright, eliminating embolism and invigorating blood circulation, relaxing muscles and tendons and activating QI and blood in the collateral, nourishing the brain and improving intelligence.Strongly fragrant and the brain cell repair function of its exclusive soothing liver-QI row to reconciling the depressed mind of patient, activates the function of dormancy brain cell in ischemia half blanking bar, and good result is all played in the prevention of stroke recurrence.
Attending scope: cure mainly cerebral thrombosis, cerebral infarction, cerebral hemorrhage, cerebral trauma, brain atrophy and sequela thereof: hemiplegia, numb limbs and tense tendons, arthrogryposis, facial hemiparalysis, sialorrhea, dysphonia, aphasia, bradykinesia, hypomnesis, senile dementia, spirit depressing etc.Mental retardation of children, dementia that arteriosclerosis, hyperlipidemia, encephalitis sequela and acquired disposition are caused also have good efficacy, and have the function of prevention of stroke recurrence.
The present invention treats apoplexy 39 routine clinical reports:
Cerebrovascular disease is one of most important disease that threatens human health.All exponentially increases with the growth at age for the sickness rate of ischemic cerebrovascular, prevalence and mortality rate in recent years, is bordering on straight line and rises.Data shows that the residual rate of cerebrovascular disease survivor limb is up to 60-80%.Cerebrovascular disease has the characteristics of easy recurrence, has the cerebrovascular disease of 20-75% to recur in 2-5 according to statistics.In addition, many cerebrovascular disease patients are not with acute formation onset, and show as dementia, limb movement disturbance or psychological problem more.At present cerebrovascular is not still had and well prevent and treat method, to the rarely seen especially report of the rehabilitation research of apoplexy sequela.The inventor was from 2003, and using prescription drug of the present invention in clinical is that main treatment apoplexy sequela amounts to 39 examples, now the result is reported as follows:
One, research method
1, the comprehensive overview of the object of observation
Observed 39 apoplexy sequela patients altogether, wherein the male is 32,7 of women.Minimum 45 years old of age, maximum 79 years old, 64 years old mean age; The shortest 1 year of medical history time, the longest more than 12 years; The whole physical disabilities of 39 people, its order of severity difference, wherein 10 with the position aphasia, 6 function of deglutition forfeitures in the aphasia, gatism.39 patients mainly are distributed in Baoji city and peripheral province.
2, the method for Guan Chaing
Utilize the inventor to be engaged in traditional Chinese medical science work of rehabilitation, the patient according to different body constitution and disease, selected for use the invention described above prescription to do among a small circle and adjusts in hospital, with the patient take the present invention fill a prescription before and after the own control of symptom of Chinese medicine preparation judge its health status.And by visiting or understanding patient's rehabilitation situation by phone.During multiplexing medicine of the present invention, except physics massage rehabilitation, the patient does not take other medicine.
3, clinical symptoms: disturbance of consciousness 23 examples, aphasia 10 examples, completeness 33 examples of paralysing, paresis 6 examples, cerebral hemorrhage 39 examples (internal capsule hemorrhage 5 examples, thalamic hemorrhage 12 examples, hemorrhage 11 examples of Basal ganglia, hemorrhage 11 examples in other position), cerebral thrombosis 31 examples.Chinese medical discrimination stirring of wind due to deficiency of YIN type and type of QI-stagnation and blood stasis be 20 example and 19 examples respectively.
4, diagnostic criteria: all cases are all made a definite diagnosis by the standard and the cranium brain CT examination of whole nation cerebrovascular disease academic conference revision for the second time in 1986.Chinese medical discrimination typing reference literature (Ministry of Public Health: new Chinese medicine clinical research guideline, the 1st volume, 1993:33).
5, efficacy evaluation: with reference to Ministry of Public Health " the clinical research guideline of new Chinese medicine treatment apoplexy ".
Two, instructions of taking
1, dosage: take the preparation that contains the former medicine of 9 grams (adopt water decoction or make fine powder more than 100 orders) according to patient's situation at every turn, every day three times, advise ante cibum eliminating cold for resuscitation water clothes down.
2, the patient takes the time that preparation of the present invention tells on
39 routine apoplexy patients take most of 30-40 of time days that medicine of the present invention tells on, and the minimum time of working only is 20 days, and the longest time of working is 5 months.
3, untoward reaction
The patient takes in the process, and no serious adverse reaction takes place.Its untoward reaction symptom shows as the slight discomfort of stomach etc., all can tolerate, and need not any treatment, suitably reduces dosage and can recover voluntarily.
Three, result of study
1, the residual improvement of limb
(1), extremely significantly improves: have 4 examples extremely significantly to improve the residual symptom of limb in 39 examples, do not pay special attention to generally promptly not see that he has the residual symptom of limb.A year and a half is not seen the state of an illness repeatedly yet after the drug withdrawal.
(2), significantly improve: have 20 examples significantly to improve the residual symptom of limb in 39 examples.The pain sensation, thermo aesthesia and proprioceptive sensation obstacle half side among these patients largely improve, and the person that originally not can't take care of oneself can reach substantially and take care of oneself.
(3), certain improvement: have 9 in 39 examples routine limb is residual and necessarily improved, promptly hands, lower limb become soft, mobility increase etc.
2, aphasia is improved
(1), extremely significantly improve: 4 examples return to the talkative language that relatively links up in the 10 routine aphasias, and language function recovers substantially.
(2), significantly improve: 4 examples return to talkative simple sentence in the 10 routine aphasias.
3, the improvement of function of deglutition forfeiture: patient's function of 6 function of deglutition forfeitures is restored fully.
4, the improvement of gatism: the function of 6 gatism is recovered fully.
Four, conclusion and discussion
1, conclusion: this research topic shows that Drug therapy apoplexy sequela limb of the present invention is residual, aphasia etc. has the effect that extremely significantly improves or significantly improve.Effective percentage to physical disabilities reaches 84.6%.
2, discuss: hemorrhagic apoplexy, cerebral infarction convalescent period, diseases such as deficiency of kidney-YIN, excessive rising of liver-YANG, blood stasis due to qi deficiency are arranged more, medicinal granule for treating hemiparalysis has effects such as nourishing YIN to subdue liver-wind, disperse blood stasis and dredge collateral, removing heat by catharsis expells the pathogenic heat, so stirring of wind due to deficiency of YIN type and Qi deficiency blood stasis type apoplectic hemiplegia are had better curative effect.Pharmacodynamic study shows; medicine of the present invention can alleviate cerebral edema; promote intracranial hematoma to absorb; antithrombotic forms; and improve this research topic of hemorheology and show; active ingredient of drugs of the present invention can see through blood brain barrier; activate impaired brain cell and recover its function, repair impaired nerve, repair impaired blood brain barrier; the protection cerebral tissue; can improve patient function of nervous system, promote intracranial hematoma to absorb, reduce disability rate; recovering operate as normal and viability, is the good medicine of treatment apoplexy sequela.
The specific embodiment
Embodiment 1:
Rhizoma Arisaematis (processed) 6, the Rhizoma Pinelliae 12, Rhizoma Typhonii 4, Rhizoma Chuanxiong 20, Scolopendra 6, Scorpio 12, Pheretima 15, Rhizoma Gastrodiae 20, Caulis Akebiae 15, Fructus Atriplicis Sibiricae 20, the Radix Astragali 40, Cortex Magnoliae Officinalis 20, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 15, Radix Salviae Miltiorrhizae 25, Rhizoma Acori Graminei 10, Poria 25, Radix Polygalae 15, Radix Codonopsis 25, Flos Carthami 5, Radix Saposhnikoviae 20, Myrrha 10, Radix Notoginseng 11, Lignum Sappan 15.All Chinese medicines are made decocting liquid after mixing.
Embodiment 2:
Rhizoma Arisaematis (processed) 12, the Rhizoma Pinelliae 6 Rhizoma Typhoniis 8, Rhizoma Chuanxiong 10 Scolopendras 12, Scorpio 6, Pheretima 25, Rhizoma Gastrodiae 10, Caulis Akebiae 25, Fructus Atriplicis Sibiricae 10, the Radix Astragali 60 Cortex Magnoliae Officinalis 10, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 25, Radix Salviae Miltiorrhizae 15, Rhizoma Acori Graminei 20, Poria 15, Radix Polygalae 25, Radix Codonopsis 15, Flos Carthami 7, Radix Saposhnikoviae 10, Myrrha 20, Radix Notoginseng 7, Lignum Sappan 25.All components is made the above fine powder of 100 orders after mixing, through the lonizing radiation radiation sterilizing.
Embodiment 3:
Rhizoma Arisaematis (processed) 9 Rhizoma Pinelliaes 9 Rhizoma Typhoniis 6 Rhizoma Chuanxiongs 15 Scolopendras 9 Scorpios 9 Pheretimas 20 Rhizoma Gastrodiaes 15 Caulis Akebiaes 20 Fructus Atriplicis Sibiricaees 15 Radixs Astragali 50 Cortex Magnoliae Officinalis 15 Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus)s 20, Radix Salviae Miltiorrhizae 20 Rhizoma Acori Gramineis 15 Poria 20 Radix Polygalaes 20 Radix Codonopsis 20 Flos Carthamis 6 Radix Saposhnikoviaes 15 Myrrhas 15 Radix Notoginseng 9 Lignum Sappans 20.Adopt water decoction to make concentrated oral liquid.

Claims (2)

1. Chinese medicine preparation for the treatment of the apoplexy sequela is characterized in that being made by following weight portion raw material of Chinese medicine:
Rhizoma Arisaematis (processed) 6-12, Rhizoma Pinelliae 6-12, Rhizoma Typhonii 4-8, Rhizoma Chuanxiong 10-20,
Scolopendra 6-12, Scorpio 6-12, Pheretima 15-25, Rhizoma Gastrodiae 10-20,
Caulis Akebiae 15-25, Fructus Atriplicis Sibiricae 10-20, Radix Astragali 40-60 Cortex Magnoliae Officinalis 10-20,
Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 15-25, Radix Salviae Miltiorrhizae 15-25, Rhizoma Acori Graminei 10-20, Poria 15-25,
Radix Polygalae 15-25, Radix Codonopsis 15-25, Flos Carthami 5-7, Radix Saposhnikoviae 10-20,
Myrrha 10-20, Radix Notoginseng 7-11 Lignum Sappan 15-25.
2. the Chinese medicine preparation of treatment apoplexy sequela according to claim 1 is characterized in that being made by following weight portion raw material of Chinese medicine:
Rhizoma Arisaematis (processed) 9 Rhizoma Pinelliaes 9 Rhizoma Typhoniis 6 Rhizoma Chuanxiongs 15 Scolopendras 9 Scorpios 9
Pheretima 20 Rhizoma Gastrodiaes 15 Caulis Akebiaes 20 Fructus Atriplicis Sibiricaees 15 Radixs Astragali 50 Cortex Magnoliae Officinalis 15
Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 20, Radix Salviae Miltiorrhizae 20 Rhizoma Acori Gramineis 15 Poria 20 Radix Polygalaes 20 Radix Codonopsis 20
Flos Carthami 6 Radix Saposhnikoviaes 15 Myrrhas 15 Radix Notoginseng 9 Lignum Sappans 20.
CN2007100188449A 2007-09-28 2007-09-28 Traditional Chinese medicine preparation for treating cerebral apoplexy sequela Expired - Fee Related CN101152458B (en)

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Publication number Priority date Publication date Assignee Title
CN102973794A (en) * 2012-11-15 2013-03-20 龚允志 Dissolved medicine with blood activating and health care functions
CN104208609A (en) * 2013-05-31 2014-12-17 朱乃香 Traditional Chinese medicine named as "Annaoning"
CN105055694A (en) * 2015-08-04 2015-11-18 山东中医药大学附属医院 Traditional Chinese medicine for treating depression caused by pathogenic fire derived from stagnation of liver-qi
CN105878769A (en) * 2014-10-08 2016-08-24 马中杰 Medicine formula for preventing cerebral infarction and treating stroke sequelae
CN109847042A (en) * 2019-04-25 2019-06-07 河南省中医院(河南中医药大学第二附属医院) Traditional Chinese medicine cerate for treating spasticity of shoulder-hand syndrome after cerebral apoplexy

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102973794A (en) * 2012-11-15 2013-03-20 龚允志 Dissolved medicine with blood activating and health care functions
CN102973794B (en) * 2012-11-15 2015-09-09 龚允志 A kind of Chinese medicine for the treatment of cerebral infarction, cerebral thrombosis
CN104208609A (en) * 2013-05-31 2014-12-17 朱乃香 Traditional Chinese medicine named as "Annaoning"
CN104208609B (en) * 2013-05-31 2017-11-24 朱乃香 It is peaceful to pacify brain
CN105878769A (en) * 2014-10-08 2016-08-24 马中杰 Medicine formula for preventing cerebral infarction and treating stroke sequelae
CN105055694A (en) * 2015-08-04 2015-11-18 山东中医药大学附属医院 Traditional Chinese medicine for treating depression caused by pathogenic fire derived from stagnation of liver-qi
CN105055694B (en) * 2015-08-04 2016-03-30 山东中医药大学附属医院 A kind of Chinese medicine preparation for the treatment of fire derived from stagnation of liver-QI type depression
CN109847042A (en) * 2019-04-25 2019-06-07 河南省中医院(河南中医药大学第二附属医院) Traditional Chinese medicine cerate for treating spasticity of shoulder-hand syndrome after cerebral apoplexy

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