CN101152233A - Pharmaceutical composition of snakegourd fruit and folium ginkgo - Google Patents
Pharmaceutical composition of snakegourd fruit and folium ginkgo Download PDFInfo
- Publication number
- CN101152233A CN101152233A CNA200610159484XA CN200610159484A CN101152233A CN 101152233 A CN101152233 A CN 101152233A CN A200610159484X A CNA200610159484X A CN A200610159484XA CN 200610159484 A CN200610159484 A CN 200610159484A CN 101152233 A CN101152233 A CN 101152233A
- Authority
- CN
- China
- Prior art keywords
- extract
- pharmaceutical composition
- fructus trichosanthis
- folium ginkgo
- crude drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Abstract
Description
Group | Proportioning | Dosage (/kg) | Maximum agglutination rate |
Matched group YINXINGYE ZHUSHEYE group Fructus Trichosanthis injection group melon silver injection group | - - - 100+1000 300+800 400+600 500+400 800+300 1000+200 1100+180 1300+160 1500+150 1700+120 2000+100 | 3ml 250mg crude drug 1g crude drug 250mg crude drug 250mg crude drug 250mg crude drug 250mg crude drug 250mg crude drug 250mg crude drug 250mg crude drug 250mg crude drug 250mg crude drug 250mg crude drug 250mg crude drug | 90.20±17.75 80.75±19.36 * 75.32±17.93 * 70.23±16.88 * 71.58±15.37 * 66.04±13.44 *# 60.32±12.03 **#& 55.63±14.20 **##& 50.40±12.81 **##&& 54.38±13.86 **##& 56.27±17.25 **#& 55.41±18.20 **#& 59.36±16.49 *# 60.03±12.32 *# |
Group | Proportioning | Dosage | Time-to-live/min |
Matched group model control group Folium Ginkgo group Fructus Trichosanthis sheet group melon silver strip group | - - - - 100+1000 300+800 400+600 500+400 800+300 1000+200 1100+180 1300+160 1500+150 1700+120 2000+100 | 3ml/kg-250mg crude drug/kg 1g crude drug/kg 250mg crude drug/kg 250mg crude drug/kg 250mg crude drug/kg 250mg crude drug/kg 250mg crude drug/kg 250mg crude drug/kg 250mg crude drug/kg 250mg crude drug/kg 250mg crude drug/kg 250mg crude drug/kg 250mg crude drug/kg | 36.9±3.8 10.4±2.5 # 15.7±2.8 * 16.3±3.1 * 20.9±2.4 * 22.5±1.9 * 25.4±2.7 * 33.5±2.3 **△& 37.6±3.8 **△& 40.3±1.2 **△△&& 36.4±2.9 **△& 35.1±2.4 **△& 33.2±1.8 **△& 25.5±2.6 * 23.4±3.9 * |
Group | Before the experiment | After the modelling | After the administration 20 days |
Dosage group melon silver strip high dose group in the blank group hyperlipidemia model group Fructus Trichosanthis sheet group Folium Ginkgo group melon silver strip low dose group melon silver strip | 1.86±0.15 1.85±0.12 1.84±0.28 1.86±0.21 1.83±0.27 1.85±0.20 1.87±0.13 | 1.90±0.22 7.83±1.70 7.86±1.58 7.87±1.64 7.86±1.52 7.84±1.41 7.81±1.54 | 1.87±0.21 7.80±1.84 ## 6.53±1.29 6.25±1.38 4.23±1.60 * 3.12±1.73 **△& 2.35±1.32 **△& |
Group | Before the experiment | After the modelling | After the administration 20 days |
Dosage group melon silver strip high dose group in the blank group hyperlipidemia model group Fructus Trichosanthis sheet group Folium Ginkgo group melon silver strip low dose group melon silver strip | 0.53±0.17 0.56±0.24 0.57±0.32 0.52±0.27 0.55±0.13 0.57±0.18 0.54±0.14 | 0.54±0.18 1.12±0.30 1.11±0.25 1.02±0.22 1.05±0.23 1.10±0.21 1.15±0.30 | 0.52±0.10 1.10±0.23 ## 0.86.±0.19 0.85±0.24 0.54±0.15 * 0.55±0.14 * 0.57±0.20 * |
Group | When arrhythmia occurs/min | Arrhythmia is held time/s | VF/ | VT/ | VPB/ |
Dosage group melon silver granule high dose group in the normal saline matched group Folium Ginkgo granule group Fructus Trichosanthis granule group melon silver granule low dose group melon silver granule | 0.60±0.47 5.62±3.78 * 5.68±4.56 * 5.49±2.79 * 16.6±4.61 **△& 12.6±3.52 **△& | 600.09±296.78 300.58±295.36 * 304.63±251.48 * 320.87±276.22 * 156.29±23.34 **△& 164.69±49.71 **△& | 8 6 5 7 3 0 | 8 5 3 5 3 1 | 8 4 2 6 2 1 |
Batch | The Fructus Trichosanthis crude extract | The Fructus Trichosanthis extract | ||
1 2 3 | Steroidal compounds content (%) 24.95 24.90 25.03 | Yield (%) 7.5 7.2 7.8 | Steroidal compounds content (%) 33.62 33.59 33.62 | Yield (%) 3.40 3.38 3.42 |
On average | 24.96 | 7.5 | 33.61 | 3.40 |
Batch | Total pyrite alcohol glycosides content (%) | Terpene lactone contents (%) | Extract yield (%) |
1 2 3 | 24.5 25.0 24.6 | 6.3 6.6 6.6 | 2.17 2.15 2.13 |
On average | 24.7 | 6.5 | 2.15 |
Claims (10)
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CN103304490A (en) * | 2013-06-18 | 2013-09-18 | 聊城大学 | Method for separating and purifying five purine and pyrimidine bases from trichosanthes bark |
CN104706778A (en) * | 2015-02-13 | 2015-06-17 | 淄博夸克医药技术有限公司 | Medicine for treating herpes zoster |
CN107375356A (en) * | 2017-05-31 | 2017-11-24 | 神威药业集团有限公司 | Method that is a kind of while preparing high-purity total flavonoids and ginkgolides |
CN108152437A (en) * | 2017-12-06 | 2018-06-12 | 广州卡马生物科技有限公司 | American Ginseng reference extract and its preparation method and application |
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CN103304490A (en) * | 2013-06-18 | 2013-09-18 | 聊城大学 | Method for separating and purifying five purine and pyrimidine bases from trichosanthes bark |
CN104706778A (en) * | 2015-02-13 | 2015-06-17 | 淄博夸克医药技术有限公司 | Medicine for treating herpes zoster |
CN107375356A (en) * | 2017-05-31 | 2017-11-24 | 神威药业集团有限公司 | Method that is a kind of while preparing high-purity total flavonoids and ginkgolides |
CN107375356B (en) * | 2017-05-31 | 2020-06-16 | 神威药业集团有限公司 | Method for simultaneously preparing high-purity total flavonol glycosides and ginkgolides |
CN108152437A (en) * | 2017-12-06 | 2018-06-12 | 广州卡马生物科技有限公司 | American Ginseng reference extract and its preparation method and application |
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