CN101147850A - System for making nanometer level particle - Google Patents
System for making nanometer level particle Download PDFInfo
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- CN101147850A CN101147850A CNA2006101542366A CN200610154236A CN101147850A CN 101147850 A CN101147850 A CN 101147850A CN A2006101542366 A CNA2006101542366 A CN A2006101542366A CN 200610154236 A CN200610154236 A CN 200610154236A CN 101147850 A CN101147850 A CN 101147850A
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Abstract
The present invention provides a system for preparing nano-grade particles. Said system includes the following several portions: a microdroplet spraying device, including a liquor storage tank, a flow channel, an actuator ad an orifice, for producing nano-grade droplets; a control system, providing energy for said microdroplet spraying device and making it spray out said droplets; and a drying device for drying said droplets and making them be formed into nano-grade particles.
Description
Technical field
The present invention is about a kind of system, and especially in regard to a kind of system that is used to make nanometer particle.
Background technology
Nanosecond science and technology are widely used in various sciemtifec and technical spheres such as biochemistry, medicine, chemical industry.With the drug delivery in the biochemical pharmaceutical sector is example, and medicament nanoization then can effectively be increased the surface area of drug particle, so quicken medicine absorption rate (adsorption rate), increase the absorptivity (bioavailability) of human body for medicine.Because the key point of drug therapy is that can human body fully absorb, so size of pharmaceutical particles, particle diameter distribution situation can directly affect the treatment.
Existing micro-nanoization of medicine manufacture craft is divided into physical method and chemical method haply.Physical method commonly used at present is mainly electrostatic spraying (electrospray), ultrasonic dispersion (ultrasound), spraying dry (spray drying), supercritical fluid (supercritical fluid), freezing manufacturing methods such as (cryogenictechnologies).Wherein, the U.S. Pat 3208951 disclosed Electrostatic Spray Technology problem that the particle diameter skewness arranged and contain organic solvent; U.S. Pat 5389379 disclosed ultrasonic dispersion technologies and U.S. Pat 5639441, the disclosed supercritical fluid cloth of US6095134, US6630121 discharge technique have the problem of particle diameter inequality; So U.S. Pat 3016308 disclosed spraying dry technologies are owing to the drop of the reason ejection that utilizes gas pressurized can't evenly distribute, this technology still has the particle diameter problem of uneven distribution as a result, and this spraying dry technology can't be with the particle nanometer; U.S. Pat 5015332 is general gas-pressurization type spray dryer, carries out the dry manufacture craft of chemical particle, and average grain diameter is about 60～70 μ m and can't reaches the requirement of nanometer particle size; U.S. Pat 6582285, the disclosed wet lapping technology of US6431478 then have the shortcoming of manufacture craft vulnerable to pollution, particle diameter skewness.Though these methods mostly can obtain the micron or even the particle diameter of nano-scale, and following shortcoming is all arranged respectively: for example, lay back drop random distribution, contain that organic solvent, granulation speed are too slow, particle diameter skewness etc.; And, be not that all manufacture crafts all are fit to volume production.In addition, chemical method comprises methods such as emulsion polymerization, interfacial polymerization, condensed phase separation, and can produce the particle diameter of nano-scale haply, but following shortcoming is also arranged: for example, manufacture craft is amplified difficulty, particle diameter skewness etc.
In sum, most nanoparticle technology all has the uneven problem of particle diameter size, though this problem can utilize back segment screening manufacture craft with the particle classification, this follow-up processing can increase the complexity and the problem that causes cost to promote of manufacture craft.But therefore how to develop a mass production or stages of labor amplify and but the manufacture craft of homogeneous nanometer is important and necessary.
Summary of the invention
One of main purpose of the present invention is exactly to cooperate the subsequent drying manufacture craft to produce nano_scale particle with ink-jet (Inkjet priming) technology.In fact, the present invention lays device with ink-jet and will desire the solution of nanometer particulate and lay and produce the micron order drop, cooperates follow-up dry manufacture craft again and produces nano_scale particle.
For reaching above-mentioned purpose, one embodiment of the present invention provides a kind of system that is used to make nanometer particle, comprise: a little drop lays device, wherein to lay device be that a kind of ink-jet lays device to this little drop, comprise a liquid storage district (tank), a runner (channel), an actuator (actuator) and a spray orifice (orifice), be used to produce micron order drop (droplet); One control system provides this little drop to lay the device energy so that this drop ejection; And a drying device, make this droplet drying to form nanometer particle (particle) by the mode of drying.
Another preferred embodiment of the present invention provides a kind of system that is used to make nanometer particle, comprise: a little drop lays device, wherein to lay device be that a kind of ink-jet lays device to this little drop, comprises a liquid storage district, a runner, an actuator and a spray orifice, is used to produce the micron order drop; One pressure control device is used to keep the pressure stability that this little drop lays device, avoids changing because liquor capacity changes build-up of pressure in the operating process; One control system provides this little drop to lay the device energy so that this drop ejection; And a drying device, make this droplet drying to form nanometer particle by the mode of drying.
Another preferred embodiment of the present invention provides a kind of system that is used to make nanometer particle, also comprises: a particle collection device is used to collect this nanometer particle.
Another preferred embodiment of the present invention provides a kind of system that is used to make nanometer particle, also comprises: one is used to stablize the device of this drop injection direction, is to lay at this little drop to avoid the disorderly or collision mutually of this drop injection direction when device lays drop.The above-mentioned device that is used to stablize this drop injection direction is installed in this little drop and lays the device front end, and shape comprises horn-like or the pipe shape, avoid this drop to be subjected to airflow influence, thus avoid because of this drop injection direction disorderly or mutually collision because of the phenomenon of a drying particulate particle diameter inequality.
In sum, low cost, drop are small, particle diameter distributes equal first-class advantage because ink-jet seal technology has, just can make the nano_scale particle of particle diameter distribution homogeneous with easy equipment, cheap cost so the present invention handles manufacture craft in conjunction with the drying of ink-jet seal technology and subsequent droplet, and this technology can be applicable to give birth to fields such as doctor, chemistry, photoelectricity.
For above and other objects of the present invention, feature and advantage can be become apparent, cited below particularlyly go out preferred embodiment, and cooperate appended accompanying drawing, be described in detail below:
Description of drawings
Fig. 1 illustrates the schematic diagram of making the method for nanometer particle in one embodiment of the present invention.
Fig. 2 illustrates the profile of the system that is used to make nanometer particle in one embodiment of the present invention.
Fig. 3 illustrates the enlarged drawing that little drop of system among Fig. 2 lays device 220.
Fig. 4 illustrates the enlarged drawing that little drop of system among Fig. 2 lays device 220.
The particle diameter that Fig. 5 illustrates present embodiment gained nanometer particle distributes.
Fig. 6 illustrates the profile of the system that is used to make nanometer particle in another preferred embodiment of the present invention.
The particle diameter that Fig. 7 illustrates present embodiment gained nanometer particle distributes.
The primary clustering symbol description
100～system;
110～little drop lays device;
112～drop;
115～drying device;
117～bottom;
119～arrow;
119a～arrow;
120～liquid feed device and pressure control device;
125～hot blast;
130～control system;
140～nitrogen original device;
150～inner ring road system;
160～particle collector;
170～particle filter;
200～system;
210～drying device;
220～little drop lays device;
230～spray orifice end;
240～liquid transmission pipeline;
250～nitrogen feeds mouth;
260～thermostatted water feeds mouth;
270～high-temperature gas feeds mouth;
The outlet of 280～high-temperature gas;
290～bottom;
The little drop of 300～ink-jet lays device;
The liquid storage district of 310～liquid;
320～microchannel chip;
330～micro-spraying hole;
2000～horn-like device.
The specific embodiment
First embodiment
Fig. 1 illustrates the schematic diagram of making the method for nanometer particle in one embodiment of the present invention.As shown in Figure 1, this system 100 comprises that little drop lays device 110, drying device 115, little drop and lays the liquid feed device of device 110 and the control system 130 that pressure control device 120, little drop lay device 110, the nitrogen original device 140 of system 100, inner ring road system 150, particle collector 160 and the particle filter 170 of system 100.
It for example is that a kind of ink-jet lays device that little drop lays device 110, comprises a liquid storage district (figure does not show), a runner (figure does not show), an actuator (figure does not show) and a plurality of spray orifices (figure does not show).Wherein, this actuator drives a plurality of spray orifices, can will desire the solution ejection of nanometer to produce micron order drop (droplet) 112; This actuator can be hot bubble type actuator or piezo actuator.In the present embodiment, it is a drug solution that little drop lays in the device 110, and its solid content is 2.5% and is solvent with alcohol.Drying device 115 is used for collecting and dry drop 112, for example is high temperature drying device or hot-air drying device.Liquid feed device and pressure control device 120 can be stablized for transfusion fluid and can stablize the little drop of control and lay the required pressure of device 110, avoid changing build-up of pressure because of liquor capacity in the operating process and change, wherein the driving force of pressure control device 120 comprises that mechanical force, draught head or potential energy are poor.Control system 130 can provide little drop to lay device 110 different-energy pulses or other hydrojet parameter.Because the drug solution that native system 100 is desired to lay is to be solvent with the organic solvent, and this equipment needs operation at high temperature, therefore must provide stable nitrogen to make intrasystem oxygen be lower than a certain particular value, with the doubt of avoiding exploding, so nitrogen original device 140 is set.In other embodiments, little drop lays device 110 and also can make water as solvent.Inner ring road system 150 can reclaim nitrogen reusing (can be used as after this nitrogen heating dry-heat air with), and the condensation function is provided and reclaims organic solvent.Particle collector 160 and particle filter 170 can avoid particle diffusion to environment.
In the present embodiment, liquid feed device and pressure control device 120 inject little drop with drug solution and lay device 110, drive that little drop lays device 110 and with the drug solution ejection by control system 130, and drying device 115 in formation micron order drop 112.Simultaneously, nitrogen original device 140 injects nitrogen in the drying device 115, forms hot blast 125 and makes micron order drop 112 dryings that laid device 110 ejections by little drop, and form nanometer particle (dried droplets 112).Afterwards, because the relation of gravity, nanometer particle can be settled down to drying device 115 bottoms 117, and follow the direction of arrow 119 to be collected at particle collector 160 places, residual nanometer particle then be captured (trapped) in the nitrogen at particle filter 170 places, at last, used nitrogen then is recovered via inner ring road system 150, and follows the direction of arrow 119a to enter drying device 115 once again and reuse.In this embodiment, in order to control the flow field of drop 112, the front end (exit) that lays device 110 at little drop is installed the device (figure does not show) that is used to stablize this drop injection direction, avoids the disorderly or collision mutually of drop 112 injection directions when device 110 lays drop 112 to lay in little drop.Wherein, the above-mentioned shape that is used to stablize the device of this drop injection direction can be horn-like or the pipe shape.
Fig. 2 illustrates the profile of the system that is used to make nanometer particle in one embodiment of the present invention.As shown in Figure 2, this system 200 utilize high-temperature gas drying mode and with droplet drying to form nanometer particle.This system 200 comprises that drying device 210, little drop lay that spray orifice end 230, liquid transmission pipeline 240, nitrogen that device 220, little drop lay device feed mouthfuls 250, thermostatted water feeds mouthfuls 260, high-temperature gas feeds mouthfuls 270, the bottom 290 of high-temperature gas outlet 280 and drying device 210.
In addition, it is detailed as shown in Figure 3 that little drop of native system 200 lays the partial enlarged drawing of device 220.It can be that a little drop of ink-jet lays device 300 that little drop lays device 220, and wherein the liquid storage district 310 of liquid also is the feed liquor district, and liquid will be ejected by the fluid channel (figure does not show) that arrives chip herein again.
As shown in Figure 4,320 is the microchannel chip that the little drop of ink-jet lays device 300, and 330 is the micro-spraying hole that the little drop of ink-jet lays device 300.
In the present embodiment, ginseng Fig. 1, the operating process and the parameter of native system 100 are as follows.At first, make nitrogen be full of drying device 115 and be warming up to temperature requiredly, for example be 100 ℃.After system 100 stablizes, control little drop and lay device 110 so that drug solution stably sprays, wherein the solvent of drug solution is that alcohol, hydrojet frequency are 0.3K Hz.When little drop lays after device 110 stably sprays drop 112, because drop 112 is quite small and lay to the high temperature environment and can reach drying effect at once; In addition, the solid content of conjugate solutions and Formula Design can make dried particle reach the effect of nanometer and uniform particle diameter.At last, collect required nanometer particle via gathering-device 160.The particle diameter that Fig. 5 illustrates present embodiment gained nanometer particle distributes.Wherein, average grain diameter is 576.0am and uniform particle diameter, shows that native system 100 has remarkable nanometer effect and particle diameter is quite consistent.
Second embodiment
Fig. 6 illustrates the profile of the system that is used to make nanometer particle in another preferred embodiment of the present invention.As shown in Figure 6, except spray orifice end 230 places that lay device at little drop install additional the horn-like device 2000, all the other are identical with system 200 shown in Figure 6.
This horn-like device 2000 is mainly used in the drop of avoiding the ink gun ejection and disorderly flies or collide each other to assemble to influence the homogeneity of nano particle and the stability of production because of the drop that the influence that is subjected to heated air stream causes spraying.The experimental procedure of present embodiment, the parameter of system are all identical with the 1st embodiment, do not add at this and give unnecessary details.The experimental result of present embodiment gained as shown in Figure 7, average grain diameter is a more homogeneous of 398.0nm and particle diameter, shows after native system 200 and horn-like device 2000 collocation to have remarkable nanometer effect and uniform particle diameter.In other embodiments, horn-like device 2000 also can be replaced by pipe shape device.
In sum, the above embodiment of the present invention is made the nanometer particle of uniform particle diameter by integrating ink-jet seal technology and follow-up dry forming manufacture craft.And in system, be provided for stablizing the device of this drop injection direction and the gathering-device of nanometer particle, to collect the particle of drying and nanometer.Because the particle of institute of system of the present invention output has homogeneous particle diameter, thereby can significantly reduce cost of manufacture and shorten time of manufacture craft.So compared to conventional art, system of the present invention has uniform particle diameter and device simple, with low cost, the easy advantage of manufacture craft.And the nanometer particle of manufacturing of the present invention has the advantage that uniform particle diameter distributes, and can apply to make medicine, can increase human body for the absorptivity of medicine and improve the dissolubility of medicine in blood, helps to promote aspect diagnosis and treatment the curative effect of medicine.
Though the present invention with several preferred embodiments openly as above; right its is not in order to qualification the present invention, any insider, without departing from the spirit and scope of the present invention; when can changing arbitrarily and retouching, so protection scope of the present invention is as the criterion when looking claims person of defining.
Claims (14)
1. system that is used to make nanometer particle comprises:
One little drop lays device, and wherein to lay device be that a kind of ink-jet lays device to this little drop, is used to produce the micron order drop;
One control system provides this little drop to lay the device energy to order about this drop ejection; And
One drying device makes this droplet drying to form nanometer particle by the mode of drying.
2. the system that is used to make nanometer particle according to claim 1 is characterized in that this actuator comprises hot bubble type actuator or piezo actuator.
3. the system that is used to make nanometer particle according to claim 1 is characterized in that, this actuator can drive odd number or a plurality of spray orifice.
4. the system that is used to make nanometer particle according to claim 1 is characterized in that, this drying device is the high temperature drying device.
5. the system that is used to make nanometer particle according to claim 1 is characterized in that, this drying device is a hot-air drying device.
6. the system that is used to make nanometer particle according to claim 1 is characterized in that, the employed gas of this drying device comprises nitrogen.
7. the system that is used to make nanometer particle according to claim 1 is characterized in that, this little drop lay device with an organic solvent or water as solvent.
8. system that is used to make nanometer particle comprises:
One little drop lays device, and wherein to lay device be that a kind of ink-jet lays device to this little drop, is used to produce the micron order drop;
One pressure control device is used to keep the pressure stability that this little drop lays device, avoids changing because liquor capacity changes build-up of pressure in the operating process;
One control system provides this little drop to lay the device energy to order about this drop ejection; And
One drying device makes this droplet drying to form nanometer particle by the mode of drying.
9. the system that is used to make nanometer particle according to claim 8 is characterized in that this actuator comprises hot bubble type actuator or piezo actuator.
10. the system that is used to make nanometer particle according to claim 8 is characterized in that, the driving force of this pressure control device comprises that mechanical force, draught head or potential energy are poor.
11. the system that is used to make nanometer particle according to claim 8 is characterized in that, this drying device is a hot-air drying device.
12. the system that is used to make nanometer particle according to claim 8 is characterized in that, also comprises:
One particle collection device is used to collect this nanometer particle.
13. the system that is used to make nanometer particle according to claim 8 is characterized in that, also comprises:
One is used to stablize the device of this drop injection direction, is to lay at this little drop to avoid the disorderly or collision mutually of this drop injection direction when device lays drop.
14. the system that is used to make nanometer particle according to claim 13 is characterized in that, this device that is used to stablize this drop injection direction is installed in this little drop and lays the device front end, and shape comprises horn-like or the pipe shape.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2006101542366A CN101147850B (en) | 2006-09-18 | 2006-09-18 | System for making nanometer level particle |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2006101542366A CN101147850B (en) | 2006-09-18 | 2006-09-18 | System for making nanometer level particle |
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| CN101147850A true CN101147850A (en) | 2008-03-26 |
| CN101147850B CN101147850B (en) | 2010-08-25 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104334266A (en) * | 2012-03-14 | 2015-02-04 | 霍尼韦尔国际公司 | Method and apparatus for prilling with pressure control |
| CN104549042A (en) * | 2013-10-25 | 2015-04-29 | 仲兆准 | Preparation method and device of micro-nano dry powder based on ultrasonic spray drying |
| CN105395367A (en) * | 2014-09-12 | 2016-03-16 | 北京瑞芬生物科技有限公司 | Device for preparing ginkgo biloba extract nanometer powder |
| CN105582683A (en) * | 2014-10-21 | 2016-05-18 | 中国科学院上海药物研究所 | Dynamically-monitored high-frequency ultrasound atomized particle preparation system |
| CN105581983A (en) * | 2014-10-21 | 2016-05-18 | 中国科学院上海药物研究所 | High-frequency ultrasonic atomized particle preparation system |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1280875A (en) * | 1999-06-30 | 2001-01-24 | 刘士群 | Process and equipment for preparing microparticles with supercritical back extractant |
| CN101053803A (en) * | 2006-04-14 | 2007-10-17 | 研能科技股份有限公司 | Manufacturing system for fine particles and manufacturing method |
| CN101062470A (en) * | 2006-04-29 | 2007-10-31 | 研能科技股份有限公司 | Micro granule manufacturing system and technique |
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2006
- 2006-09-18 CN CN2006101542366A patent/CN101147850B/en not_active Expired - Fee Related
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104334266A (en) * | 2012-03-14 | 2015-02-04 | 霍尼韦尔国际公司 | Method and apparatus for prilling with pressure control |
| CN104549042A (en) * | 2013-10-25 | 2015-04-29 | 仲兆准 | Preparation method and device of micro-nano dry powder based on ultrasonic spray drying |
| CN104549042B (en) * | 2013-10-25 | 2018-11-09 | 苏州大学 | Micro-nano process for preparation of dry powder and device based on ultrasonic atomizatio drying |
| CN105395367A (en) * | 2014-09-12 | 2016-03-16 | 北京瑞芬生物科技有限公司 | Device for preparing ginkgo biloba extract nanometer powder |
| CN105395367B (en) * | 2014-09-12 | 2021-12-24 | 北京瑞芬生物科技股份有限公司 | Equipment for preparing ginkgo biloba extract nanopowder |
| CN105582683A (en) * | 2014-10-21 | 2016-05-18 | 中国科学院上海药物研究所 | Dynamically-monitored high-frequency ultrasound atomized particle preparation system |
| CN105581983A (en) * | 2014-10-21 | 2016-05-18 | 中国科学院上海药物研究所 | High-frequency ultrasonic atomized particle preparation system |
| CN105582683B (en) * | 2014-10-21 | 2019-01-18 | 中国科学院上海药物研究所 | The high frequency ultrasound atomized particles preparation system of dynamic monitoring |
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| CN101147850B (en) | 2010-08-25 |
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