CN101132737A - Systems and methods for detecting abnormal cells - Google Patents
Systems and methods for detecting abnormal cells Download PDFInfo
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- CN101132737A CN101132737A CNA2006800068506A CN200680006850A CN101132737A CN 101132737 A CN101132737 A CN 101132737A CN A2006800068506 A CNA2006800068506 A CN A2006800068506A CN 200680006850 A CN200680006850 A CN 200680006850A CN 101132737 A CN101132737 A CN 101132737A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
- A61B10/0291—Instruments for taking cell samples or for biopsy for uterus
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Abstract
A cell collector and cell collection method are provided for collecting clusters of cells for subsequent analysis of the cells to screen for abnormalities. The cell collector is designed to enhance the capability of the collector to pick-up clusters or clumps of cells, and to facilitate transfer of the collected clusters of cells onto a receiving . structure, for example a slide. In one embodiment, a combination of the material of the collector, the texture of the collection surface of the collector, and the use of expansion and rotation of the collector during collection facilitate the collection of the clusters of cells.
Description
The application requires the U.S. Provisional Application No.60/642 of submission on January 6th, 2005,008, the U.S. Provisional Application No.60/681 that submitted on May 17th, 2005,901, the U.S. Provisional Application No.60/686 that submitted on June 1st, 2005,150, the U.S. Provisional Application No.60/708 that submitted on August 15th, 2005,150, the U.S. Provisional Application No.60/729 that submitted on October 25th, 2005,854, the U.S. Provisional Application No.60/729 that submitted on October 25th, 2005, the priority of the U.S. Patent Application Serial Number (the unknown) of 857 and 2005 on Decembers submission in 23.Each application cited above in full with referring to mode include this paper in.
Technical field
The collection of the cell cluster that the cell cluster after relate generally to of the present invention is used for detects.More particularly, the present invention relates to be designed to improve catcher obtains the ability of cell cluster or cell cluster from for example uterus catcher, wherein the steric mode of the cell cluster that is collected with preservation of cell cluster is collected.
Background technology
Usually be necessary that collecting various cell samples from patient screens, with detection and the final treatment that is used for multiple disease and abnormity.The one of the main reasons of collection of cellular samples is to be used to screen the cancer patient.For example, by cytotech and pathologist urine, saliva, nipple and fine needle aspiration thing and cervix uteri are peeled off cell and screen, check that there is the paracytic existence of solid tumor in prompting.In case find this suspicious cells, the sample by shifting out the tissue of suspecting the place that damage is arranged is also given the pathologist with sample and is checked and realize more definite diagnosis.
Generally accepted is that the main chance of effective treatment can be provided in the diagnosis of cancer earliest period.The inference of this saying is that the early diagnosis of solid tumor is corresponding to being identified in the local anomaly that cellular level is different from surrounding tissue.This has proposed the challenge of screening cell sample under environment that does not have whole flanking cells and situation relatively.A kind of solution of this problem is to concentrate on tightr approximate complete unitary each unit, the i.e. groups of cells organized.In fact, can think that this cell cluster is therein or before the existence prompting cancer of itself or carcinous state.Yet the sample that also exists the normal structure unit to collect being used for cytological analysis shows as the situation of cell cluster.
The routine sampling method that adopts in the current screening process can be obtained cell from lesion, usually these cells is dispersed in the common quantity of obtaining then and wants the much bigger normal cell outside the pathological changes border.This dispersion causes assess sample to become the activity that detects rare event; That is, in the background that the normal cell of very large amount (for example 50,000-300,000) is formed, find one or several abnormal cell.And, and may be most important ground, disperse to have eliminated by the information that biological property obtained from the zonule of determining to represent preneoplastic lesion.Exist in the intercellular relation of this necessary information, and by check with tissue in the individual cells of adjacent cell separation be unconspicuous.Disperse also to hinder and use sample to determine diseased region on the patient.
Therefore, also wish to provide be convenient to cell cluster collection and keep collecting before the improved cell collection method of the existing spatial relationship of iuntercellular.
Summary of the invention
A kind of cell harvestor and cell collection method are provided, be used for clusters of cells for follow-up cell analysis with the screening abnormity.This cell harvestor is designed to be able to improve the ability that catcher is kept the integrity of cell cluster or cluster, and the cell cluster of being convenient to collect is transferred to and accepted on structure such as the microscope slide.In one embodiment, the material of catcher, catcher are collected the collection that the combination that utilizes catcher to expand and rotate during surperficial texture and the collection helps cell cluster.
The mode of the spatial relationship that the iuntercellular before preferably, cell cluster can be kept and sample in the cell cluster exists is transferred to from catcher and is accepted structure.Catcher and the structural description point of acceptance help during transfer to keep spatial relationship.
Expand catcher during the collection and during the transitional cell.Expansion during collecting and shifting is by using air, by the mechanical expansion system, or realizes by the combination of air and mechanical system.Preferably, can during transfer expand catcher, the cell cluster from interior Exocervix zone is stood on (end up) common basically plane, accept structure for transferring to subsequently.
Cell cluster collection is used in many body regions, for example cervix uteri, bladder, pulmonary, colon and ovary.Can wash clusters of cells such as cell from saliva, the ovary of tissue, urine, generation.
Description of drawings
Figure 1A-C has shown from the example of cervix uteri collecting cell.
Fig. 2 A and 2B are respectively the cutaway views according to the side view of an embodiment of cell harvestor assembly of the present invention and A-A intercepting along the line.
Fig. 2 C is the detail drawing of the expandable collection tip of cell harvestor assembly.
Fig. 3 is the cutaway view that is attached to the cell harvestor of catcher Handleset.
Fig. 4 person's of being to use hands grips the sketch map of catcher Handleset.
Fig. 5 A-C is the cutaway view at cell harvestor tip, has shown the expansion at cell harvestor tip during the cell cluster collection.
Fig. 6 A-C has shown the step of use cell harvestor from the cervix uteri clusters of cells.
Fig. 7 A-C has shown the catcher Handleset that can rotate cell harvestor during collecting.
Fig. 8 A-B has shown before the inflation respectively and afterwards but the tip of the cell harvestor before shifting, and the color marker that has of cell cluster that simulation collects is arranged.
Fig. 9 has shown another embodiment of catcher Handleset.
Figure 10 has shown another embodiment of cell harvestor and catcher Handleset.
Figure 11 A-C is the detail drawing at tip of the cell harvestor of Figure 10, and showing during collecting is how to expand and rotate.
The specific embodiment
Catcher is configured to improve the ability that catcher is gathered cell cluster or cluster, and is convenient to the cell cluster of collecting transferred to and accepts on structure such as the microscope slide.In one embodiment, the combination of the application that catcher is expanded and rotated during the texture on the material of catcher, catcher collection surface, the collection helps the collection of cell cluster.The cell cluster collected can be transferred to from catcher in the mode of the spatial relationship that exists between the cell that keeps the sampling pre-group and concentrate then and be accepted structure.Catcher and accept spatial relationship during structural orientation mark helps to keep transfer.
For the purpose of explaining, below with reference to describing notion of the present invention with screen for cervical cancer from the cervix uteri clusters of cells.Yet will be appreciated that, notion of the present invention also can for example be collected to screen bladder cancer, collect to screen pulmonary carcinoma, collect to screen breast carcinoma, collect to screen colon cancer and collect to screen ovarian cancer from ovary from colon from breast from lung from bladder by be used for the screening of other disease from other regional clusters of cells of health.Can wash clusters of cells such as cell from saliva, mammary secretion, the ovary of tissue, urine, generation.
Figure 1A-C has shown from the notion of cervix uteri 50 clusters of cells.Figure 1A has shown the cervix uteri 50 that is formed by uterus 52, and cervix uteri comprises the transition region 58 from the inside cervix uteri extension of Exocervix of cervical canal 60, interior cervix uteri 56, Exocervix 62 and shadow representation.Show in the transition region 58 at exemplary pathological changes 54 cervix uteri 56 places in Cervical.
Figure 1B has shown the notion that can be used for from the cell harvestor 100 of cervix uteri 50 collecting cells and cell cluster.Catcher 100 has the surface 104 that adapts to the cervix uteri contour line, and this surface 104 has can be by it from interior cervix uteri and Exocervix 62, the 56 clusters of cells character with the spatial relationship between the cell cluster of guaranteeing to keep collecting from transition region 58 clusters of cells, simultaneously.
In addition, catcher 100 has observable orientation mark 106, so that the individual of clusters of cells can directional collector when cervix uteri is taken a sample, and cell cluster subsequently be transferred to have equally orientation mark 108 corresponding shown in Fig. 1 C accept structure 101 time keep this orientation.By surface 104 is contacted with the structure 101 of accepting that is constructed to be permeable to make cell cluster be transferred to structure 101 rather than keep being attached to surface 104, cell cluster can be transferred to accepts structure 101.During the transfer, orientation mark 106,108 alignment makes in case shift, and the cell cluster on the structure 101 has and they identical spatial relationships on catcher 100.But analysis of cells is trooped possible unusual to screen then.
With reference now to Fig. 2 A-C,, shown the details that embodies the cervical cell collector assembly 150 of notion of the present invention.Collector assembly 150 comprises the removable hollow pipe 200 that is connected expandable collection tip 201.Pipe 200 is made by for example plastics or cardboard.Expandable tip 201 also is the cell harvesting zone of catcher 150, be the resilient flexibility structure of being made by for example elastomeric material of thermoplastic elastomer alloy, described thermoplastic elastomer alloy is such as the Versaflex CL30 for obtaining from GLS Corp. of Illinois McHenry.Expanding tip 201 preferably has can improve the texture of catcher from the ability of transition region 58 collecting cell clusters when most advanced and sophisticated 201 expansions and rotation.For example, tip 201 can have the texture of MT-11010.It is most advanced and sophisticated 201 that other elastomeric material also can be used for, for example microporous polyvinyl acetate, nitrile rubber, nitrile foam, urethane foam, silicone rubber, latex rubber, polyurethane and have low durometer, high elongation and suitably texture with other elastomer of the collection that promotes cell cluster.
Fig. 3-5 has shown and has been arranged on the cell harvestor assembly that is used to gather cell sample on the catcher Handleset 303.Assembly 303 comprises inner sleeve 308 and trocar sheath 307, and pipe 200 is provided with around trocar sheath 307, and trocar sheath 307 is slidably disposed on the inner sleeve 308.Probe 306 stretches into the inside of expandable tip 201 forward from the inside of inner sleeve 308.Expander probe 305 centers on the end that probe 306 is arranged on assembly 303, and the end 320 of probe 305 is arranged in the trocar sheath 307 in trocar sheath 308 ends.The opposite end 322 of probe is expanded and is comprised shoulder 324.
Trocar sheath 307 also comprises pipeline locking piece 309.Pipeline locking piece 309 comprises the flexible member that is fixed in trocar sheath 307, and the hole 332 (seeing Fig. 2 A and 2B) that forms on the pipe 200 of collector assembly 150 is passed in its projection that makes progress.Pipeline locking piece 309 and hole 332 associations are equipped with the trocar sheath 307 that pipe 200 is locked in Handleset 303.
Again with reference to figure 3, back-moving spring 310 is arranged in the trocar sheath 307 and is terminal and be arranged between the spring compressor 311 of trocar sheath 307 ends at inner sleeve 308.Spring 310 is to the right side of Fig. 3 biasing trocar sheath 307, and the inner sleeve 308 of setovering to the left simultaneously is so that trocar sheath 307 and inner sleeve 308 return to initial position shown in Figure 3.
As Fig. 3 and 4 best image, the diameter of trocar sheath 307 from the smaller diameter portion of the pipe 200 that is designed to admit catcher 150 change to contiguous handle 213 and among Fig. 3, extend to supporting member 313 right sides than the major diameter part.Smaller diameter portion and form shoulder 216 (Fig. 4) than the transition between major diameter part, the end of pipe 200 abuts against shoulder 216.When needing, the angle that end 202 tiltables of pipe 200 form with coupling shoulder 216.When collector assembly 150 cunnings installed on the Handleset 303, the angle on the angle of shoulder 216 and the pipe 200 can be alignd, to help to guarantee collector assembly 150 correct orientation on Handleset 303.
Fig. 4 is the sketch map with thumb press hand-held handle 312 on spring compressor 311.Fig. 5 A-C and Fig. 6 A-C have shown the collection process of using cell harvestor assembly 150 with Fig. 4.User at first is inserted into cell harvestor assembly 150 on the Handleset 303.Like this, the tip region 210 of probe 306 tip engages expandable tip 201 makes expandable tip flatten and the shoulder 208 of reduction temporarily most advanced and sophisticated 201, shown in Fig. 5 A and 6A.This has improved the sight line that is used for catcher is inserted Cervical user.
Then, user pushes spring compressor 311 with thumb or other finger, as shown in Figure 4.This makes trocar sheath 307 along with expander probe 305 moves forward together, shown in Fig. 5 B.When probe 305 when moving forward, the shoulder 208 of expandable tip 201 is expanded outwardly, shown in Fig. 5 B and 6B from flat form.After advancing about 8-10 millimeter expander probe 305 with pop one's head in 306 terminally when concordant, the 305 spy ends of expander probe, are shown in Fig. 5 B.Cervical canal is extremely about 6 millimeters in expander probe 305 expansions, expandable tip 201 contact shoe cervical canals.305 visit the end in case pop one's head in, and continue to push with thumb to make trocar sheath 307 continue to move about 3-4 millimeter again, promote pipe 200 simultaneously forward.As a result, the shoulder 208 of expandable tip 201 and/or transition portion 212 compressions are resisted against on the Exocervix 62, shown in Fig. 6 C.
During it moved, expander probe 305 expanded into and the cooperating of interior cervix uteri 56 tip region 210 of expandable tip 201.In addition, the shoulder 208 of expandable tip 201 and/or transition portion 212 compressions are against the outer surface of cervix uteri 50.As a result, can collect interior cervix uteri and Exocervix cell, comprise the cell of transition region 58.
Also rotatable expandable tip 201 during the collection, with under the help of most advanced and sophisticated 201 texture by shearing cell clusters from transition region 58 from the transition region clusters of cells.Most advanced and sophisticated 201 rotate for example 20-30 degree.Can rotate most advanced and sophisticated 201 by manual rotary handle assembly 303 of user and connected collector assembly 150.Perhaps, it is most advanced and sophisticated 201 to use suitable mechanical rotating mechanism to rotate, and this rotating mechanism just makes most advanced and sophisticated 201 rotations when contacting with interior cervix uteri and Exocervix in case Handleset 303 expands into most advanced and sophisticated 201 tip region 210, shoulder 208 and transition portion 212.
The example that has shown mechanical rotating mechanism as Fig. 7 A-C.Fig. 7 A has shown the collector assembly 150 that is arranged on the Handleset 250.Assembly 250 comprises U-shaped end portion 252 and expansion and rotating part 254, thereby expansion rotatably is connected U-shaped end portion 252 with rotating part 254 part 254 can be rotated with respect to end portion 252.Construct the end of most advanced and sophisticated 201 parts that center on 254 to be similar to the mode shown in Fig. 5 A-C.The opposite end of part 254 is provided with helical tooth 256 on its outer surface.
Between the operating period of assembly 250, be installed to collector assembly 150 on the Handleset 250 after, when user inserted probe, probe 305 (shown in Fig. 5 A-C) moved forward, and caused most advanced and sophisticated 201 expansions (Fig. 5 B).User continues to push, and makes most advanced and sophisticated 201 further to expand to cooperate against Exocervix (Fig. 5 C).Can stop further insertion with Exocervical the cooperation, cause that grip sleeve 258 moves forward along the direction of arrow among Fig. 7 C.Grip sleeve 258 final moving enough far to contact with helical tooth 256.Continue to advance grip sleeve 258 and meshing spiral tooth that part 254 is rotated shown in arrow among Fig. 7 C with catcher 150.
Inserting, expanding and rotating with after realizing cell cluster collection, release pressure and back-moving spring make mechanism get back to initial position.Pipeline locking piece 309 is depressed, and removes cervical cell collector assembly 150 then.
Fig. 9 has shown another embodiment of the catcher Handleset 400 that cell harvestor assembly 150 is installed on it.Assembly 400 comprises front tube 402, and the front end of front tube is connected with deflector 404.Handleset 400 is designed so that the pipe 200 of collector assembly 150 slips into pipe 402 so that collector assembly 150 to be installed.When collector assembly 150 was installed on the assembly 400, deflector 404 flattened the shoulder 208 on most advanced and sophisticated 201, to improve the insertion sight line during collecting.Pipe 402 also is included near the slit 406 its rear end.Similar Fig. 5 A-C ground structure pipe 200 is around the inside of the pipe 402 of its setting.
Being in the home position at Fig. 9 the Show Button 412, also is the on position of assembly 400.After suitably inserting, user is button push 412 backward, and button 412 moves to the rear button position to the end of groove 410.Because button 412 414 is connected with projection, projection 414 also moves backward, pulls back the deflection at the collection tip 201 that front tube 402 causes with release deflector 404 with respect to collector assembly 150.Then, user promotes button 412 forward and collects most advanced and sophisticated 201 with expansion.Button 412 is connected in the expanding mechanism shown in Fig. 5 A-C, makes button the most forward position from the home position of button to button in groove 410 can cause expansion.
After the collection, cell cluster can be transferred to from most advanced and sophisticated 201 and be accepted structure to carry out the subsequent analysis of cell cluster.The suitable example of structure of accepting comprises: microscope slide, culture dish and cell cluster can be shifted to carry out other structure of cell subsequent analysis.The surface that the surface ratio of accepting structure contains the tip 201 of cell cluster has bigger adhesiveness, with promote cell cluster from the tip to the transfer of accepting structure.When accepting structure and be microscope slide, this microscope slide can have the bigger adhering coating of generation.
Preferred tip 201 during the transfer with air inflation catcher 150.When most advanced and sophisticated 201 were made by thermoplastic elastomer alloy such as Versaflex CL30, the tip can evenly be expanded during elastomer made inflation.During the inflation, tip region 210 and transition portion 212 leave (seeing Fig. 8 B) basically, make cell cluster on tip region 210 and the transition portion 212 finally basically on common plane, accept on the structure so that cell cluster is transferred to subsequently.This helps to keep the spatial relationship of cell mass concentrated cell.
After the transfer, can remove most advanced and sophisticated 201 and be placed on and contain the container that preservative agent troops with the remaining cell of preserving on most advanced and sophisticated 201 from managing 200.Then, abandon pipe 200 or be connected to new tip 201 further to collect.If most advanced and sophisticated 201 do not need to preserve then discardable most advanced and sophisticated 201.
Fig. 8 A has shown the tip 201 of catcher, and this tip has coloured label 500 of the transition zone cell clusters of simulation collection.Fig. 8 B has shown the tip 201 of inflation, and how thin out coloured label that analog cell troops 500 is shown but still as seen.
With reference now to Figure 10 and 11A-C,, shown another embodiment 10 that is used in the cervical cell collector of cervical canal collecting cell among the figure.In this example, cervical cell collector 10 is made of an assembly, this assembly comprises flexible cell sample zone 12 and the rigidity pusher 22 that adjoins, comprise second assembly in the rigidity pusher, second assembly comprises the point dilator 16 that is rotatably installed on the rigid core element 14, one stack features 31 of point dilator matches with the corresponding actuating feature 32 of core element 14, and second stack features 33 cooperates the matching characteristic of pusher 34.The actuating feature 32 of core element 14 for example is constructed with the screw thread of suitable pitch.The lancet (stylette) 18 that is attached to core element 14 passes the opening 20 on the point dilator 16.
Shown in Figure 11 A, 11B and 11C, cervical cell collector can change between extended state (Figure 11 A), intermediateness (Figure 11 B) and collapsed mode (Figure 11 C).The clinician is inducted into the desired degree of depth in the cervical canal (with most advanced and sophisticated depth representing) with the tip of the cervical cell collector under the extended state 10, shown in Figure 11 A.Under this state, pusher 22 retractions, cell sample spare 12 is roughly complied with the outer surface of point dilator 16.In case the clinician just advances pusher and core element 14 and lancet 18 maintenance transfixions towards cervical orifice (os) after the tip of cervical cell collector 10 is suitably located in cervical canal.When the feature 31 and 34 of pusher 22 cooperates with the individual features 32 and 33 of core element 14 and point dilator 16 respectively, advance pusher 22 to make point dilator 15 move and center on immobilized core element 14 towards cervical orifice equally and rotate.Simultaneously, the propelling pair cell of pusher 22 sampling part 12 has applied compression stress, thereby causes its outer radial against cervical orifice outwards to be out of shape, shown in Figure 11 B and 11C.Point dilator 16 pushed in cell sample spare 12 most advanced and sophisticated the tip diameter of cell sample spare 12 is increased, thereby the outer surface of cell sample spare 12 is oppressed on the wall of cervical canal.Point dilator 16 helps point dilator with respect to rotatablely moving of cell sample spare 12 inner surfacies and enters, thus expansion cell sample spare.
Cell sample spare 12 can make the cervix cells that comes off be attached to the outer surface of cell sample spare against contacting with rotation of cervical orifice and cervical canal.The retraction of pusher 22 causes point dilator 16 to withdraw from from the tip of cell sample spare 12, and makes cell sample spare can get back to its initial extended state.Then, can take out cervical cell collector 10 from cervical canal 100 and vagina, being collected in the lip-deep cell of cell sample spare is that analysis is standby.
Use has the catcher of above-mentioned feature and collects the inside and outside cell cluster of cervix uteri.Can collect sample by internist or health care worker.Perhaps, can train women oneself and collect sample.
Though described the present invention in conjunction with the preferred embodiments, for a person skilled in the art clearly, can realize other purpose of the present invention and improvement and still in authority of the present invention and scope.
Various aspects of the present invention and described form are fit to reach other purpose of claiming and advantage very much.Described details is not regarded limitation of the present invention as.
Claims (17)
1. cervical cell collector comprises:
Main body; And
Elastic surface, be positioned at a end near described main body, described elastic surface has the texture that contacts that is fit to from Cervical Exocervix zone and interior cervix uteri zone clusters of cells, described elastic surface is made by the material that described elastic surface can evenly be expanded, and described elastic surface is rotatable
Wherein, when described elastic surface expansion and rotation, the contact texture of described elastic surface promotes described elastic surface from Exocervix and interior cervix uteri zone clusters of cells.
2. cervical cell collector as claimed in claim 1 is characterized in that, described elastic surface is arranged on the tip portion of described main body one end.
3. cervical cell collector as claimed in claim 2 is characterized in that described tip portion is detachably connected to described main body.
4. cervical cell collector as claimed in claim 1 is characterized in that the material of described elastic surface comprises thermoplastic elastomer alloy.
5. cervical cell collector as claimed in claim 1 is characterized in that, described contact texture comprises MT-11010.
6. cervical cell collector as claimed in claim 1 is characterized in that, also comprises at least one orientation indicator that is provided with near described elastic surface.
7. cervical cell collector as claimed in claim 1, it is characterized in that, described elastic surface comprises and expands shoulder, tip region and at described tip region and the described transition portion that expands between the shoulder during collecting, and wherein said elastic surface expansible to described tip region and described transition portion disappears basically and described tip region and described transition portion on cell cluster stand on degree on the roughly common plane.
8. cell harvestor that comprises rotatable collection surface, the described surface of collecting is made by the material that described collection surface energy is evenly expanded, and the contact texture that described collection surface has suitable clusters of cells, the contact texture on wherein said collection surface promotes described collection surface collection cell cluster during described collection surface rotation.
9. cell harvestor as claimed in claim 8 is characterized in that described material comprises thermoplastic elastomer alloy.
10. cell harvestor as claimed in claim 8 is characterized in that, described contact texture comprises MT-11010.
11. cell harvestor as claimed in claim 8, it is characterized in that, described collection surface clusters of cells on two surfaces during collecting, and described collect the surface expansible to described two surfaces and described two lip-deep cell clusters stand on degree on the roughly common plane.
12. a method that is used to collect cervical cell, described method comprises:
Troop in Cervical Exocervix zone and interior cervix uteri zone exposing cell, described cell cluster contacts with the elastic surface of catcher, and the described elastic surface with contact texture is fit to from Exocervix and interior cervix uteri zone clusters of cells;
Expand the described elastic surface of described catcher; And
Rotate described elastic surface with respect to Exocervix and interior cervix uteri zone;
Wherein, when described elastic surface expansion and rotation, the described contact texture of described elastic surface promotes described elastic surface from Exocervix and interior cervix uteri zone clusters of cells.
13. method as claimed in claim 12 is characterized in that, described expansion step comprises the described catcher of mechanical expansion.
14. method as claimed in claim 12 is characterized in that, described method comprises the described elastic surface of manual rotation.
15. method as claimed in claim 12 is characterized in that, described method comprises the described elastic surface of machinery rotation.
16. method as claimed in claim 12 is characterized in that, described method comprises the about 20-30 degree of the described elastic surface of rotation.
17. method as claimed in claim 12 is characterized in that, described method is rotated described elastic surface after being included in the described elastic surface of expansion.
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64200805P | 2005-01-06 | 2005-01-06 | |
| US60/642,008 | 2005-01-06 | ||
| US60/681,901 | 2005-05-17 | ||
| US60/686,150 | 2005-06-01 | ||
| US60/708,150 | 2005-08-15 | ||
| US60/729,857 | 2005-10-25 | ||
| US60/729,854 | 2005-10-25 | ||
| US11/318,025 | 2005-12-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101132737A true CN101132737A (en) | 2008-02-27 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2006800069547A Pending CN101132738A (en) | 2005-01-06 | 2006-01-04 | Systems and methods for detecting abnormal cells |
| CNA2006800068506A Pending CN101132737A (en) | 2005-01-06 | 2006-01-04 | Systems and methods for detecting abnormal cells |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2006800069547A Pending CN101132738A (en) | 2005-01-06 | 2006-01-04 | Systems and methods for detecting abnormal cells |
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| Country | Link |
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| CN (2) | CN101132738A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113116397A (en) * | 2019-12-30 | 2021-07-16 | 上海科罡医疗技术有限公司 | Esophageal wall cell sampler |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3057512B1 (en) * | 2013-10-14 | 2019-07-03 | DNA Research Centre (M) SDN BHD | Exocervical and endocervical cell sampling device |
-
2006
- 2006-01-04 CN CNA2006800069547A patent/CN101132738A/en active Pending
- 2006-01-04 CN CNA2006800068506A patent/CN101132737A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113116397A (en) * | 2019-12-30 | 2021-07-16 | 上海科罡医疗技术有限公司 | Esophageal wall cell sampler |
| CN113116397B (en) * | 2019-12-30 | 2023-02-28 | 上海科罡医疗技术有限公司 | Esophageal wall cell sampler |
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| Publication number | Publication date |
|---|---|
| CN101132738A (en) | 2008-02-27 |
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