CN101129710A - Natural medicament for treating metabolism complex and method of preparing the same - Google Patents
Natural medicament for treating metabolism complex and method of preparing the same Download PDFInfo
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- CN101129710A CN101129710A CNA2007101493896A CN200710149389A CN101129710A CN 101129710 A CN101129710 A CN 101129710A CN A2007101493896 A CNA2007101493896 A CN A2007101493896A CN 200710149389 A CN200710149389 A CN 200710149389A CN 101129710 A CN101129710 A CN 101129710A
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Abstract
The invention relates to a crude drug for treating metabolism complex symptom and the preparing method. The preparing method comprises the following steps: disintegrating or extracting Dioscorea japonica with water; concentrating; drying; making solid preparation or liquid preparation with the active component and the acceptable vector on the medicine or excipient according to the general method; or making the active component and traditional or western medicine compatibility; making solid preparation or liquid preparation with the compatibility active component and the acceptable vector on the medicine or excipient. The clinical test result indicates that the drug can treat 'the metabolism complex symptom' effectively, wherein the metabolism complex symptom includes concentric adiposity, the abnormal lipid metabolism (cholesterol rises, triglyceride rises and low density lipoprotein rises), dysglycemia ( abnormal sugar tolerance quantity and 2 type diabetic), the effective ratio is about 85%, and the invention has the good effect.
Description
Technical field
The present invention relates to a kind of natural drug for the treatment of metabolism syndrome and preparation method thereof, this medicine is particularly useful for metabolism obstacles of blood glucose, the unusual and central obesity disease of lipid metabolism etc.
Background technology
Since last century, along with the raising of scientific and technological level, living standard has also had large increase in the economic fast development global range.Along with growth in the living standard, a lot of local people's life style has also had very big change, the consumption of high fat, high heat food increases considerably, the people's activities amount reduces, it is fat to cause fat therefrom, central obesity particularly, the crowd who is called abdominal obesity again increases sharply, meanwhile some metabolic diseases such as metabolism obstacles of blood glucose (comprise impaired glucose tolerance, type 2 diabetes mellitus), lipid metabolism unusual (comprising that plasma triglyceride level concentration raises ldl concn rising etc.) significantly rises etc. the sickness rate of disease.Along with scientist to obesity particularly central obesity (abdominal obesity) and metabolism obstacles of blood glucose, relation research goed deep between lipid metabolism was unusual, it is found that these diseases often appear on one's body the same individuality simultaneously, and the people who has only single disease seldom, therefore, World Health Organization (WHO) in 1998 this syndrome of Committee of Experts's definite designation is " metabolism syndrome ".
Past, people are such as obesity central obesity (abdominal obesity), metabolism obstacles of blood glucose, the lipid metabolism independent disease of regarding as such as unusual particularly, treatment just is conceived to single disease, and to interkniting between these diseases, interacting, it is not enough to pay attention to, and does not also have a kind of ideal natural drug that can treat each composition of metabolism syndrome simultaneously till now.
The invention provides a kind of medicine for the treatment of metabolism syndrome, this medicine can treat effectively " metabolism syndrome " comprise obesity particularly " central obesity " be called abdominal obesity again, lipid metabolism unusual (comprising that T-CHOL raises, triglyceride raises and low density lipoprotein, LDL raises), metabolism obstacles of blood glucose (comprising impaired glucose tolerance and type 2 diabetes mellitus) etc. have good effect.
Summary of the invention
The objective of the invention is to, a kind of natural drug for the treatment of metabolism syndrome and preparation method thereof is provided, and this medicine is with the crude drug Rhizoma Dioscoreae, adopts and pulverizes or use water extraction, concentrate, dry as active component separately routinely pharmaceutical methods make solid preparation or liquid preparation; Or with active component with in, the Western medicine compatibility makes solid preparation or liquid preparation.Show through the clinic trial result, this medicine can treat effectively " metabolism syndrome " comprise obesity particularly " central obesity " be called abdominal obesity again, lipid metabolism unusual (comprising that T-CHOL raises, triglyceride raises and low density lipoprotein, LDL raises), metabolism obstacles of blood glucose (comprising impaired glucose tolerance and type 2 diabetes mellitus) etc., this medicine can be treated each composition of above-mentioned metabolism syndrome effectively, observe effective percentage about 85%, have good effect.
A kind of natural drug for the treatment of metabolism syndrome of the present invention and preparation method thereof, be with crude drug Rhizoma Dioscoreae 15-60 part, adopt and pulverize or use water extraction, concentrate, dry as active component separately with pharmaceutically acceptable carrier or excipient routinely pharmaceutical methods make solid preparation or liquid preparation; Or with active component with in, the Western medicine compatibility makes solid preparation or liquid preparation with pharmaceutically acceptable carrier or excipient again.
Preferred weight part scope of crude drug Rhizoma Dioscoreae is 20-60 part.
A kind of preparation method for the treatment of the natural drug of metabolism syndrome follows these steps to carry out:
A, weighting raw materials Rhizoma Dioscoreae weight portion 15-60 part, pulverizing was put into steam box heating 30 minutes, and is temperature 95-100 ℃, dry or with weight 2-5 times water extraction, extracting temperature is 90-100 ℃, extract 3 times, each 1-2 hour, filter, merging filtrate, be concentrated into 50%, drying is pulverized standby as active component;
B, the active component after step a pulverized separately with pharmaceutically acceptable carrier or excipient routinely pharmaceutical methods make capsule, tablet, granule, the solid preparation of powder or oral liquid, the liquid preparation of electuary;
C or step a pulverized after active component with in, the Western medicine compatibility makes capsule with pharmaceutically acceptable carrier or excipient, tablet, granule, the solid preparation of powder or oral liquid, the liquid preparation of electuary again;
D, with the active component of step a water extraction then separately with pharmaceutically acceptable carrier or excipient routinely pharmaceutical methods make capsule, tablet, granule, the solid preparation of powder or oral liquid, the liquid preparation of electuary;
E or with the active component behind the step a water extraction with in, the Western medicine compatibility makes capsule with pharmaceutically acceptable carrier or excipient, tablet, granule, the solid preparation of powder or oral liquid, the liquid preparation of electuary again.
The solid preparation of preparation Rhizoma Dioscoreae is broken into 120-150 order fine powder with Rhizoma Dioscoreae powder among the step a.
The liquid preparation that step a prepares Rhizoma Dioscoreae is broken into 60-80 order coarse powder with Rhizoma Dioscoreae powder.
A kind of pharmacological properties for the treatment of the natural drug of metabolism syndrome of the present invention is:
Rhizoma Dioscoreae (Rhizoma Dioscoreae) is the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae Diascoyeaopposite Thunb..Winter, stem and leaf was excavated after withering,, cut the root head, clean, remove crust and fibrous root, drying.Character: Rhizoma Dioscoreae is slightly cylindrical, and is crooked and flat slightly, long 15-30cm, diameter 1.5-5cm.Surface yellow-white or faint yellow has longitudinal furrow, vertical wrinkle and mark of fibrous root, and idol has the light brown crust residual.Function with cure mainly: the spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating is wet smart.Be used for insufficiency of the spleen lack of appetite, incessant chronic diarrhea, cough and asthma due to lung deficiency, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, deficiency-heat is quenched one's thirst.
Total water extract of Rhizoma Dioscoreae of the present invention is to the metabolic research of alimentary obesity rat:
Summary: total water extract of purpose research Rhizoma Dioscoreae is to the metabolism of alimentary obesity rat.Method: feed with the high sugared semi-synthetic high heat feedstuff of high fat to adult SD rats, cause the alimentary obesity rat model; The total water extract therapeutic test that gives Rhizoma Dioscoreae finishes the back and calculates each experimental group body weight and interior fat weight in wet base, adopts the biochemical pharmacology method to measure T-CHOL (Tch) triglyceride (TG) in each experimental group rat serum.The content of low density lipoprotein, LDL (LDL) and fasting glucose (GLU).The result: after the total water extract of Rhizoma Dioscoreae was treated the alimentary obesity rat, above-mentioned every index and model group relatively had significant difference (P＜0.05 or P＜0.01).Conclusion: the total water extract of Rhizoma Dioscoreae has antiobesity action to obese rat.Especially obviously reduce the interior fat weight in wet base, the effect of triglyceride reducing (TG), reduction low density lipoprotein, LDL (LDL), hypercholesterolemia reducing (Tch), reduction fasting glucose.
Material and method
Animal grouping: 60 of healthy male rats, body constitution amount 180-220 gram, Mus 3-4 in age month (Xinjiang Medicine University's Experimental Animal Center provides), be divided into 5 groups at random: 10 of normal control groups, 10 of not treatment groups of obesity model, 10 of obesity fenfluramine hydrochloride tablets treatment groups and the total water extract of Rhizoma Dioscoreae are treated each 15 of big small dose group.
Feed formula: the high sugared semi-synthetic high heat feedstuff (20% fat, 52% sucrose, 18% protein and an amount of salt-mixture, vitamin and cellulose etc.) of high fat; Normal diet.
Be subjected to the reagent thing: the total water extract of Rhizoma Dioscoreae is provided by the female Ma Mute of many power, get and make the medicinal liquid that every milliliter (ml) contain the total water extract 0.5g of Rhizoma Dioscoreae after the total water extract adding distil water of Rhizoma Dioscoreae mixes and use for heavy dose of group, the use said method is made the medicinal liquid that every milliliter (ml) contain the total water extract 0.25g of Rhizoma Dioscoreae and is used for small dose group.
Positive control drug: fenfluramine hydrochloride tablets (Tablet s Fenfl urami ne Hydrochlori de, TFH).Specification: every hydrochloric fenfluramine 20mg, clinical dosage are each 1, every day 3 times.Baoshan Pharmaceutical Factory, Yadong medicine Corp., Shanghai medicine Industr's product, Shanghai are defended the accurate word (1995) the 035001st of medicine, lot number 060523.Preparation: get TFH 100mg, adding distil water to 100ml mix the back 0.1% medicinal liquid use for fragrant Buddhist Lamine group.
Set up the fat model of rat: animal is divided into 2 groups at random.Be that 10 of normal control groups are fed normal diet, all the other are that fat group is fed the high heat feedstuff, the equal feed of freely drinking water of all rats.Weigh in before the experiment beginning, body weight of weighing weekly after the experiment beginning, all in weighing at 9 o'clock in the morning, when significant difference appearred in test group animal and normal control treated animal body weight, fat model was foundation after 8 weeks.
Experiment:
Fat animal pattern is divided into fat model group at random, positive drug group, the heavy dose of test group of the total water extract of Rhizoma Dioscoreae, low dose of test group.More than each group continue to give the high heat feedstuff, freely drink water, feed, with irritating the stomach mode, 10 o'clock every mornings gave big low dose of Rhizoma Dioscoreae total extract respectively by the 1ml/100g body weight, and positive controls is given and fenfluramine medicinal liquid 1ml/100g body weight, intact animal's matched group gives normal diet, freely drink water feed, 5 weeks of experimental period.
Evaluation index:
Body weight: take by weighing body weight once in a week, around the kidney, the abdominal cavity fat gravimetry: after rat put to death blood-letting, cut open respectively and get around the kidney and the whole fat of intraperitoneal take by weighing weight in wet base.
Biochemical measurement: serum total cholesterol (Tch), triglyceride (TG), low density lipoprotein, LDL (LDL), fasting glucose.
Statistics, analytical method:
Adopting SPSS to carry out the statistical disposition measurement data on computers represents with X ± S.Experimental result adopts model group and normal group relatively, and each administration group and model group compare in twos.
The result:
The total water extract of Rhizoma Dioscoreae is to the influence of obese rat body weight
As shown in table 1, when modeling finished, model group rat body weight (456.7 ± 10.9) exceeded 19% (P＜0.05) than normal saline group (368.6 ± 25.8) the modelling success is described.After 5 weeks of administration, the total water extract treatment of Rhizoma Dioscoreae group rat body weight is the preceding weight loss about 1.2% of treatment.(TFH) the positive controls rat body weight descends about 1.6% before the experiment.The model group rat body weight increases about 6% before the experiment beginning.
The total water extract of table 1 Rhizoma Dioscoreae is to the influence of obese rat body weight (mean ± SE)
| Body weight change (g) | |||||
| First week | Second week | The 3rd week | Around | The 5th week | |
| The heavy dose of group of the normal control group total water extract of fat model Rhizoma Dioscoreae Rhizoma Dioscoreae total water extract small dose group fenfluramine hydrochloride (TFH) matched group | 368.6±25.8 456.3±10.9 433.7±9.6 435.8±9.013 371.0±18.3 | 392.9±26.8 479.3±8.0 435.8±13.6 427.5±10.8 399.1±16.7 | 384.4±25.2 488.1±6.9 447.3±14.2 460.5±11.3 361.2±13.4 | 410±26.6 496.1±6.9 457±10.7 447.9±13.5 394.9±10.5 | 429.3±16.8 484.6±8.8 428.6±10.8 427.5±16.7 365.7±12.5 |
The total water extract of Rhizoma Dioscoreae is to the influence of alimentary obesity rat abdominal cavity fat weight in wet base
As shown in table 2, during off-test, large and small two the dosage group abdominal cavity fat weight in wet bases of the total water extract of Rhizoma Dioscoreae significantly are lower than model group, are starkly lower than positive controls.
The total water extract of table 2 Rhizoma Dioscoreae is to the influence of alimentary obesity rat abdominal cavity fat weight in wet base (the abdominal cavity fat weight in wet base (g) of mean ± SE)
| The heavy dose of group of normal control group model group Rhizoma Dioscoreae extract Rhizoma Dioscoreae extract small dose group fenfluramine hydrochloride (TFH) matched group | 6.46±1.83 11.84±2.82 6.0±1.2 6.0±1.17 6.9±0.83 |
The total water extract of Rhizoma Dioscoreae is to the influence of alimentary obesity rat fat:
As shown in table 3, during off-test, the total water extract of Rhizoma Dioscoreae obviously triglyceride reducing (TG) reduces low density lipoprotein, LDL (LDL) to normal level, simultaneously obvious hypercholesterolemia reducing (Tch).
The total water extract of table 3 Rhizoma Dioscoreae is to the influence of alimentary obesity rat fat TG, LDL and Tch level (mean ± SE)
| TG(mmol/l) | LDL(mmol/l) | Tch(mmol/l) | |
| The heavy dose of group of the normal control group total water extract of fat model Rhizoma Dioscoreae Rhizoma Dioscoreae total water extract small dose group fenfluramine hydrochloride (TFH) matched group | 1.15±0.09 1.46±0.09 1.16±0.08 1.09±0.09 1.26±0.12 | 0.21±0.02 0.32±0.01 0.17±0.02 0.18±0.02 0.25±0.03 | 0.56±0.06 0.97±0.07 0.79±0.07 0.68±0.06 0.72±0.15 |
The total water extract of Rhizoma Dioscoreae is to the influence of alimentary obesity rat fasting blood-glucose
As shown in table 4: when modeling finished, it was little respectively to organize laboratory animal blood glucose difference before the experiment beginning, and two groups of rat fasting blood-glucoses of the total water extract of Rhizoma Dioscoreae were starkly lower than other each groups when experiment finished.
The total water extract of table 4 Rhizoma Dioscoreae is to the influence of alimentary obesity rat fasting blood-glucose (mean ± SE)
| Fasting glucose changes (mmol/l) | ||
| First week | The 5th week | |
| The heavy dose of group of the normal control group total water extract of fat model Rhizoma Dioscoreae Rhizoma Dioscoreae total water extract small dose group fenfluramine hydrochloride (TFH) matched group | 3.97±0.11 4.50±0.13 4.2±0.14 3.78±0.08 4±0.12 | 3.70±0.16 4.15±0.11 2.68±0.09 2.7±0.14 3.96±0.29 |
Conclusion: the total water extract of Rhizoma Dioscoreae is compared the increase that can not only suppress rat body weight with fat rat model to experimental rat and can also be lost weight simultaneously under continuing to feed with the condition of high fat high heat feedstuff.Especially can significantly reduce obviously triglyceride reducing (TG) of experimental rat abdominal cavity fat weight in wet base and energy, T-CHOL (TCH), low density lipoprotein, LDL (LDL) significantly reduces the experimental rat fasting glucose.
Medicine of the present invention has fat-reducing, reduce the interior fat content that causes central obesity (abdominal obesity), reduce triglyceride (TG) concentration in the blood, reduce fasting glucose, reduce low density lipoprotein, LDL (LDL) content in the blood, effects such as hypercholesterolemia reducing (Tch) content.
The specific embodiment
Embodiment 1 (solid preparation)
15 parts of weighting raw materials Rhizoma Dioscoreaes (weight portion) are pulverized 120 order fine powders, put into steam box heating 30 minutes, and 95 ℃ of temperature are dry standby as active component;
Active component after step a pulverized separately with pharmaceutically acceptable carrier or excipient routinely pharmaceutical methods make the solid preparation of capsule or tablet or granule or powder;
Embodiment 2 (water extraction method prepares liquid preparation)
20 parts of weighting raw materials Rhizoma Dioscoreaes (weight portion) are pulverized 60 order coarse powder, and with the water extraction of 5 times of weight, extracting temperature is 90 ℃, extract 3 times, and each 1 hour, filter, merging filtrate is concentrated into 50%, and drying is pulverized standby as active component;
With the activity of step a water extraction become separately with pharmaceutically acceptable carrier or excipient routinely pharmaceutical methods make oral liquid, the liquid preparation of electuary.
Embodiment 3 (solid preparation)
25 parts of weighting raw materials Rhizoma Dioscoreae weight portions are ground into 150 order fine powders, put into steam box heating 30 minutes, and 95 ℃ of temperature are dry standby as active component;
Active component after step a pulverized with in, the Western medicine compatibility again with pharmaceutically acceptable carrier or excipient routinely pharmaceutical methods make capsule, tablet, granule, the solid preparation of powder.
Embodiment 4 (water extraction method prepares liquid preparation)
35 parts of weighting raw materials Rhizoma Dioscoreae weight portions are ground into 70 order coarse powder, and with the water extraction of 5 times of weight, extracting temperature is 95 ℃, extract 3 times, and each 1-2 hour, filter, merging filtrate is concentrated into 50%, and drying is pulverized standby as active component;
With the active component behind the step a water extraction with in, the Western medicine compatibility again with pharmaceutically acceptable carrier or excipient routinely pharmaceutical methods make oral liquid, the liquid preparation of electuary.
Embodiment 5 (solid preparation)
45 parts of weighting raw materials Rhizoma Dioscoreae weight portions are ground into 140 order fine powders, put into steam box heating 30 minutes, and 100 ℃ of temperature are dry standby as active component;
Active component after step a pulverized with in, the Western medicine compatibility again with pharmaceutically acceptable carrier or excipient routinely pharmaceutical methods make capsule, tablet, granule, the solid preparation of powder.
Embodiment 6 (water extraction method prepares solid preparation)
60 parts of weighting raw materials Rhizoma Dioscoreae weight portions are ground into 80 order coarse powder, and with the water extraction of 2 times of weight, extracting temperature is 98 ℃, extract 3 times, and each 2 hours, filter, merging filtrate is concentrated into 50%, and drying is pulverized standby as active component;
With the active component of step a water extraction separately with pharmaceutically acceptable carrier or excipient routinely pharmaceutical methods make capsule, tablet, granule, the solid preparation of powder.
Claims (5)
1. natural drug for the treatment of metabolism syndrome, it is characterized in that said preparation is with crude drug Rhizoma Dioscoreae 15-60 part, adopt to pulverize or use water extraction, concentrate, dry as active component separately and pharmaceutically acceptable carrier or excipient routinely pharmaceutical methods make solid preparation or liquid preparation; Or with active component with in, the Western medicine compatibility makes solid preparation or liquid preparation with pharmaceutically acceptable carrier or excipient again.
2. Rhizoma Dioscoreae preparation according to claim 1 is characterized in that preferred weight part scope of crude drug Rhizoma Dioscoreae is 20-60 part.
3. a kind of preparation method for the treatment of the natural drug of metabolism syndrome according to claim 1 is characterized in that following these steps to carrying out:
A, weighting raw materials Rhizoma Dioscoreae weight portion 15-60 part are pulverized, and put into steam box heating 30 minutes, temperature 95-100 ℃, dry or with weight 2-5 water extraction doubly, the extraction temperature is 90-100 ℃, extracts 3 times, each 1-2 hour, filter, merging filtrate is concentrated into 50%, drying is pulverized standby as active component;
B, the active component after step a pulverized separately with pharmaceutically acceptable carrier or excipient routinely pharmaceutical methods make capsule, tablet, granule, the solid preparation of powder or oral liquid, the liquid preparation of electuary;
C or step a pulverized after active component with in, the Western medicine compatibility makes capsule with pharmaceutically acceptable carrier or excipient, tablet, granule, the solid preparation of powder or oral liquid, the liquid preparation of electuary again;
D, with the active component of step a water extraction separately with pharmaceutically acceptable carrier or excipient routinely pharmaceutical methods make capsule, tablet, granule, the solid preparation of powder or oral liquid, the liquid preparation of electuary;
E or with the active component behind the step a water extraction with in, the Western medicine compatibility makes capsule with pharmaceutically acceptable carrier or excipient, tablet, granule, the solid preparation of powder or oral liquid, the liquid preparation of electuary again.
4. preparation method according to claim 2 is characterized in that the solid preparation of preparation Rhizoma Dioscoreae among the step a is broken into 120-150 order fine powder with Rhizoma Dioscoreae powder.
5. preparation method according to claim 2 is characterized in that the liquid preparation that step a prepares Rhizoma Dioscoreae is broken into 60-80 order coarse powder with Rhizoma Dioscoreae powder.
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2007101493896A CN101129710A (en) | 2007-09-11 | 2007-09-11 | Natural medicament for treating metabolism complex and method of preparing the same |
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| CNA2007101493896A CN101129710A (en) | 2007-09-11 | 2007-09-11 | Natural medicament for treating metabolism complex and method of preparing the same |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101810636B (en) * | 2010-05-13 | 2012-01-04 | 多力坤·马木特 | Application of Chinese yam polysaccharide in preparation of medicament for treating obesity |
| CN108837113A (en) * | 2018-09-07 | 2018-11-20 | 北京早服居中医研究院有限公司 | A kind of Chinese medicine and its preparation method and application improving central obesity |
| CN113101333A (en) * | 2021-04-27 | 2021-07-13 | 河南理工大学 | Application of dioscorea opposita thumb extract as only effective component in preparation of products for preventing and treating obesity |
-
2007
- 2007-09-11 CN CNA2007101493896A patent/CN101129710A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101810636B (en) * | 2010-05-13 | 2012-01-04 | 多力坤·马木特 | Application of Chinese yam polysaccharide in preparation of medicament for treating obesity |
| CN108837113A (en) * | 2018-09-07 | 2018-11-20 | 北京早服居中医研究院有限公司 | A kind of Chinese medicine and its preparation method and application improving central obesity |
| CN108837113B (en) * | 2018-09-07 | 2021-03-30 | 北京早服居中医研究院有限公司 | Traditional Chinese medicine for improving central obesity and preparation method and application thereof |
| CN113101333A (en) * | 2021-04-27 | 2021-07-13 | 河南理工大学 | Application of dioscorea opposita thumb extract as only effective component in preparation of products for preventing and treating obesity |
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Open date: 20080227 |