CN101129261A - Device and method for acquiring and recognizing pulsation information and tongue inspection information - Google Patents

Device and method for acquiring and recognizing pulsation information and tongue inspection information Download PDF

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Publication number
CN101129261A
CN101129261A CNA2007101513758A CN200710151375A CN101129261A CN 101129261 A CN101129261 A CN 101129261A CN A2007101513758 A CNA2007101513758 A CN A2007101513758A CN 200710151375 A CN200710151375 A CN 200710151375A CN 101129261 A CN101129261 A CN 101129261A
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tongue
information
image
data
pressure
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牛欣
杨学智
司银楚
朱庆文
牛淑冬
郭宙
李海燕
张治国
杜红
高蔚
董晓英
赵翠敏
翟志光
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Beijing University of Chinese Medicine
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Beijing University of Chinese Medicine
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Abstract

The invention discloses a device for acquiring and identifying the visual pulsating movement information and the tongue inspection information and an acquiring-identifying method. The device comprises a pulsating information acquiring-identifying device and a tongue inspection information acquiring-identifying device. The pulsating information acquiring-identifying device comprises the following parts: a pressure-B super composite probe 1, a B type ultrasonic scanner 2, a Vetspecs-Toe/W photoelectric capacitance-type sensor 3, a double-stroke electrocardiology lead 4, a microcomputer 5, a two-stage operational amplifier6 and a video collecting equipment7. The tongue inspection information acquiring-identifying device comprises the following parts: a color camera 8, a light source 9, a standardized positioning tongue image collecting beam cover 10, a support bracket 11, a nose pseudo 12 and a computer 13. The invention also provides a method for acquiring visual pulsating movement information and the tongue inspection information with the device. The invention achieves the digital and the visibility of Chinese medical diagnosis consideration of four diagnostic methods by associating with the tongue image information acquiring device with the pulsating information acquiring device as the central, and provides the substance basis for the wide application of clinical Chinese medical auxiliary diagnosis.

Description

A kind of devices and methods therefor that obtains identification pulsation information and tongue inspection information
Technical field
The present invention relates to a kind ofly obtain the device of identification pulsation information and tongue inspection information and obtain recognition methods, particularly relate to a kind of obtaining and discern visual pulsation information and tongue inspection information and obtain the medical diagnostic equipment of recognition methods.
Background technology
Chinese medicine is the Chinese nation's cultural sedimentary crystallization in 5,000 years, and its unique diagnosis and treatment method is gone through the check of medical practice in thousands of years with substantial, remains medical treatment and the important means that keeps healthy so far.In traditional Chinese medical science internationalization and modernization in decades, pulse-taking and inspection of the tongue are the important research contents that tcm diagnosis objectifies as main diagnostic method always.According to the nearest new result that looks into, developed some pulse-taking instrument and inspection of the tongue instrument at present both at home and abroad, but the extraction of the pulsation information of pulse-taking instrument is many based on single pressure signal; The inspection of the tongue instrument does not still have the technical standard of common recognition property; Still the integrated recognition device that obtains aglossate, that arteries and veins organically combines occurs.
Summary of the invention
The object of the invention is to provide a kind of and obtains the device of visual pulsation information of identification and tongue inspection information and obtain recognition methods.Another purpose of the present invention is to provide a kind of visual pulsation information and tongue inspection information to obtain the integrated medical diagnostic equipment of recognition technology.
The present invention seeks to be achieved through the following technical solutions.
The present invention obtains recognition device and comprises that pulsation information obtains recognition device, and this device mainly is made up of pressure-B ultrasonic combined probe 1, B mode ultrasonic scanning instrument 2, Vetspecs-Toe/W photoelectricity volume sensor 3, standard I I cardiac diagnosis lead 4, microcomputer 5, two-stage calculation amplifier 6 and video capture device 7; Wherein standard I I cardiac diagnosis lead 4, Vetspecs-Toe/W photoelectricity volume sensor 3 join with microcomputer 5 respectively through two-stage calculation amplifier 6, pressure-B ultrasonic combined probe 1 links to each other with B mode ultrasonic scanning instrument 2, and B mode ultrasonic scanning instrument 2 links to each other with microcomputer 5 by video capture device 7; Pressure B ultrasonic combined probe by B ultrasound probe 1., sleeve 2., elastica 3., transmitting medium 4., tracting pressuring hole 5., FSG-15 type pressure transducer 6., 7. sealing ring form, 1. B ultrasound pops one's head in, and the lower end is connected with B mode ultrasonic scanning instrument 2, B ultrasound probe 1. upper end inserts 2. upper end and 7. seal with sealing ring of sleeve, transmitting medium 4. be built in sealing ring 7. in, 3. elastica is fixed in sleeve lower end 2., with 2. lower end sealing of sleeve, 5. tracting pressuring hole is opened in a sleeve side 2., and 6. 5. tracting pressuring hole join with FSG-15 type pressure transducer.
2. the described sleeve of technique scheme is made by metal material, and transmitting medium is 4. for there being the filling liquid of entrant sound effect.
6. parameter is as follows for the described pressure transducer of technique scheme: working sensitivity: 0.25mV/grF; Response time: 1.0msec; Repeatability: ± 0.2%Span.
The described video capture device 7 of technique scheme can be image pick-up card.
The described microcomputer 5 of technique scheme can be desk computer or notebook computer.
The described B mode ultrasonic scanning instrument 2 of technique scheme can adopt transforms special-purpose B mode ultrasonic scanning instrument, and gain, scope, the precision of freezing frame is multistage adjustable.Probe is suitable for the measurement of superficial vein, possesses higher axial, lateral resolution, and higher frame frequency can be provided.The B mode ultrasonic scanning instrument parameter is as follows: operating frequency: 10MHz; Mechanical sector scan mode: mechanical sector scan; Resolution: vertical definition≤0.2mm; Transverse resolution≤0.4mm; Sweep limits: degree of depth 31mm~63mm; Frame frequency: 12 frame/seconds; GTG: 256 GTGs; Vernier certainty of measurement :≤0.25mm.
Above-mentioned pulsation information obtain recognition device obtain identification pulsation information method as follows:
4. 1. the B ultrasound probe launched by the transmitting medium that the entrant sound effect is arranged and received ultrasound wave, shows the two-dimensional ct image (ultrasonograph figure) of tested tissue by B mode ultrasonic scanning instrument 2; Described ultrasonic signal is the video analog signal of standard, converts it to digital signal input microcomputer 5 by video capture device 7 and handles;
The 3. stressed generation deformation of elastica changes the closed chamber internal pressure, 4. 5. passes to FSG-15 type pressure transducer 6. via tracting pressuring hole by airtight transmitting medium; 6. pressure transducer will send the preamplifier of being made up of two-stage calculation amplifier 6 input with scratching the pressure of the radial artery force signal that tremulous pulse cunkou pulse position contact acquisition by probe, and the outfan of preamplifier is imported microcomputer 5 through interface, A/D converter and handled;
The preamplifier input that the signal that standard I I cardiac diagnosis lead 4, Vetspecs-Toe/W photoelectricity volume sensor 3 obtain is formed through two-stage calculation amplifier 6, the outfan of preamplifier is handled through interface, A/D converter input microcomputer 5;
Microcomputer 5 carries out data acquisition and interpretation of result by arteries and veins figure collection, analyzing software system.Pre-process circuit is to described pick off output pressure, photoelectricity volume and electrocardiosignal is amplified, filtering, improves the quality of signal, and it is transformed to the signal that is fit to Computer Processing.Provide interface between software and hardware by AduC812 type processor.The physiological signal data stream that obtains 12 precision passes through the output of UART port, after isolating (comprising isolated from power, signal isolation) safely, is converted to the USB1.0 signal and is sent to PC.
The described arteries and veins figure of technique scheme collection, analytical system are the software section that pulsation information obtains recognition device, development platform is Windows2000sxp and Visual Basic 6.0 sp6, operation platform is Windows2000, support that by the Access data base screen resolution is 1024 * 768.Window is with close friend's graphic interface operation and observation.Can between interfaces such as dynamic image acquisition, storage, playback, data analysis, switch easily by menu.
Data acquisition master interface: can show simultaneously from top to bottom that pressure of the radial artery is tried hard to, II leads electrocardiogram, finger tip photoelectricity volume diagram and radial artery B ultrasonic image 4 road signals.Radial artery B ultrasonic acoustic image identification figure observes radial artery motion, vessel cross-sections variation real-time tracking image under the B ultrasonic.Software can monitor and export synchronously radial artery pressure pulsation ripple, Artery Vein moving image automatically, refer to that terminal volume, standard I I lead electrocardiogram four road physiological signals.Automatically show static pressure, scalable pulse pressure in view of the above, floating when getting arteries and veins with the imitation traditional Chinese medical science, in, heavy maneuver.
The data analysis interface: by analyzing key, enter the data analysis interface at main interface, the data analysis interface has following function:
1. according to cardiac cycle, leading Electrocardiographic R ripple with II serves as that sign carries out arteries and veins figure cutting automatically;
2. identification automatically:
A is the arteries and veins source of graph.
B is arteries and veins figure (main ripple) peak.
C arteries and veins figure master's ripple and second minimum point (dicrotic notch) that makes progress between ripple.
The peak (dicrotic wave) of second ripple that makes progress behind the D arteries and veins figure master ripple.
The next arteries and veins source of graph of E.
3. calculate the also position of video data ECG (electrocardiogram) starting point automatically.
4. obtain A, B, C, D, 5 different probe X-axis of E, Y-axis data automatically.
5. calculate arteries and veins figure master ripple TW (main ripple is wide), MSAB (ascending branch greatest gradient) and MSBC (descending branch greatest gradient) automatically.
6. show pulse pressure automatically.
7. carry out the average of 30 arteries and veins figure automatically or by hand, extract minutiae through data transaction, repaints the pulse wave characteristic pattern.
The pulse wave that shows in a period of time can be gathered by system; Obtain pulse amplitude-arteries and veins position, number, shape, gesture graph of a relation; Obtain the sering aspect graph; Obtain combination and special pulse-taking refinement analysis chart; Draw three-dimensional pulse-taking topography.By on the time and space, hold the dynamic change situation of getting arteries and veins position blood vessel comprehensively, acquire " position, shape, gesture, number " attribute synthesis analysis result of pulsation.Apparatus of the present invention are synchronous with the pressure data and the B ultrasonic analysis result data that collect, and synthetic two-dimensional time change sequence figure; Realization is the phase labelling method during with electrocardio, scratches the time synchronized and the position consistency analysis of the pressure pulse wave and the ultrasonic vascular image of arterial pulse wave, and image data and analysis result all may be output to printer.
The present invention obtains recognition device and comprises that also tongue inspection information obtains recognition device, and this installs mainly by colour camera 8, light source 9, and the localized tongue image acquisition shade 10 of standardization, support 11, nose standard 12, computer 13 is formed; Wherein light source 9 is around the camera lens of color video camera 8, the rear end of the localized tongue image acquisition shade 10 of external standardization; Support 11 is positioned at the fuselage lower end of video camera 8; Shade 10 front end top center have " nose standard " 12 anchor points; Colour camera 8 links to each other with computer 13 by video data transmission equipment 14.
Described light source 9 should be to have high-color rendering, even, stable be suitable for the miniature light sources that eurytopicity tongue figure gathers, and adopts annular light, colour temperature: 5200K, illumination: 5300Lum.
Described colour camera 8 preferred CCD camera, the above resolution of 640*480.
Described support 11 can adopt convenient, flexible imitative dental operation irradiation light stent-type photographic head bracing frame.
Described microcomputer 13 can be desk computer or notebook computer.
Described tongue inspection information obtains the recognition methods of obtaining of recognition device and imports computers 13 for the picture of the tongue image that colour camera 8 is gathered by video data transmission equipment 14, and computer 13 carries out collection analysis by inspection of the tongue signals collecting and analysis module to the tongue inspection information that obtains.
Described inspection of the tongue signals collecting and analysis module comprise: GUI (pattern manipulation interface) submodule, data management submodule, tongue image acquisition and pretreatment submodule, picture of the tongue are handled and are analyzed submodule.By the GUI submodule, at first call the data management submodule and set up patient's electronic health record and expert info; Call tongue image acquisition and pretreatment submodule again, carry out collection and the pretreatment of tongue figure, and deposit pretreated tongue image in data base by the data management submodule; Call picture of the tongue then and handle and analyze submodule pretreated tongue figure, carry out tongue body cut apart with tongue as feature extraction, identification tongue fur, body of the tongue, sublingual vessel and dynamic image, and deposit the picture of the tongue feature of being extracted in data base by the data management submodule.
System has realized functions such as information typing, Flame Image Process and analysis, Information Statistics, data maintenance, report printing.
(1) the automatic analysis of picture of the tongue feature
The tongue Research of Dynamic Analysis adopts the moving object tracking algorithm, and the tongue shape feature analysis adopts the dividing method of tongue arteries and veins, is divided into Global Information analysis and local information analysis.
The Global Information analysis of tongue figure:
1) based on color characteristic: colour of the tongue, coating colour, thick fur, humidity, sublingual vein etc.
2) based on textural characteristics: curdy fur, greasy coating etc.
3) based on shape facility: plump tongue, thin tongue, swollen tongue, teeth-printed tongue etc.
4) based on behavioral characteristics: trembling tongue, askew partially tongue, cripetura tongue, strong tongue, soft tongue, wagging the tongue etc. wither
5) based on comprehensive characteristics: old tongue, tender tongue, red point, prickle, tongue fur be congruence partially.
6) based on the sublingual vessel feature: the width of sublingual vessel, length, color etc.
7) based on the behavioral characteristics of tongue: cripetura, chatter, crooked or the like.
2. the part of tongue figure or microscopic information analysis:
1) feature in primary part observation zone: the colour of the tongue of regional area, coating colour, thick fur, humidity, ecchymosis etc.
2) based on tongue map analysis---crackle, the tongue boil etc. of textural characteristics.
3) excrescent bulk area and form thereof on point (fungiform papillae), thorn (filiform papillae), ecchymosis, exfoliative fur, sublingual vein, the tongue.
The picture of the tongue feature is analyzed automatically, comprising:
1) under the acquisition condition of miniaturization, improves the analytical method of existing colour of the tongue, coating colour, thick fur, humidity.
2) analysis of picture of the tongue behavioral characteristics: for the sequence tongue image, merge based on video processing technique and multiple image, analyze the vibration of picture of the tongue, askew partially, cripetura, strong, wither soft, tell behavioral characteristics such as lane.
3) tongue shape attitude Feature Extraction and analysis: characteristics of image, the object geometry feature of whole or partial tongue shape attitude feature and tongue image all have relation.In the research image shape of object express and object between the describing method of structure, realize in fat big, thin thin, the swelling, indentation, pricking method, ecchymosis, flower stripping, sublingual vein, tongue of tongue morphological characteristic analyses such as vegetation on this basis.
4) general framework of research picture of the tongue feature extraction and analysis: carry out picture of the tongue Feature Extraction and analysis from the tongue diagram data, need make full use of the priori of Traditional Chinese Medicine experts.Be necessary to study the picture of the tongue feature extraction of knowledge elicitation and the general framework of analysis,, reduce blindness to improve the effectiveness of picture of the tongue feature analysis.Comprise: the tongue image Feature Extraction; Feature selection towards the picture of the tongue analysis; Many combination of features and extraction again; The quantification of picture of the tongue feature.
(2) picture of the tongue classification and the fusion of discerning
The way that solves is to adopt Feature Fusion.But the combination of different fusion features, different Feature Fusion influence bigger to classification and recognition result.Therefore need the feature selection of research picture of the tongue sample different characteristics (as geometry feature, characteristics of image, part/global characteristics) and optimization, Feature Fusion, and the Multiple Classifier Fusion that is applicable to the picture of the tongue sample.
(3) inspection of the tongue automatization image processing flow process
Mainly can divide into three phases: (1) low order is handled, and (2) scala media is handled, and (3) high-order is handled; Low order is handled and is inspection of the tongue image, sublingual vessel image capturing digitisation stage, and scala media is treated to the feature acquisition stage, and it then is the fuzzy analysis phase of last tongue feature and sublingual vessel feature that high-order is handled.
(4) function system characteristic
Be not subject to the environment light source influence; Can dynamically obtain the picture of the tongue image of complete display; But complete analysis picture of the tongue and tongue fur are related with the internal organs reaction zone; Can carry out the color texture feature analysis; Sublingual image quantitative analysis be can finish, audit report, medical history information storehouse quantized.
The present invention obtains the visual pulsation information of identification and combines Diagnostics of Chinese Medicine comprehensive analysis of the data gained by the four methods of diagnosis principle with the tongue inspection information device, configuration tcm diagnosis prescription system.This system is made up of (1) pulse-taking signal analysis submodule, (2) inspection of the tongue signal analysis submodule, (3) inspection inquiring submodule.This system uses Visual Studio Tm Ed Sft Dev All Lng L/SA Pk OLPNLAE w/MSDN Prm Qualified exploitation under Chinese Windows2000/XP/2003.The operation hardware platform is Pentium IV 2.4GHz, the 1G internal memory, and monitor resolution is 1024 * 768, is furnished with the digital inspection of the tongue image collecting device of colored high-resolution, multiparameter pulse-taking harvester, tongue figure recognition system and pulse wave spectrum digitized detection system.The running software platform is Chinese Windows 2000/XP/2003 and SQL database system client.
(1) pulse-taking signal analysis submodule
In the diagnostic procedure, use above-mentioned pulsation information to obtain recognition device, can select to use ultrasonogram, pressure arteries and veins figure, photoelectricity arteries and veins figure and refer to modular diagnostic systems such as the volume arteries and veins figure interface of feeling the pulse, both can digital record patient pulse, can participate in dialectical again.Tradition is felt the pulse and is combined with modern technologies, and pulse-taking result dataization, standardization make the dialectical result of diagnosis more be tending towards objective.It wherein is example with the pressure signal, the pressure signal probe chip adopts up-to-date sensing element, the dynamic pressure of not only can the accurate recording pulse beating changes, and can synchronously write down the doctor and be added in static pressure on the pick off, thereby the simulation traditional Chinese medical science is pointed the process of feeling the pulse of " touching++++++++pressing and searching ", obtains the position attribution of " taking pulse lightly, moderately and heavily " of pulse condition.The analogue signal that collects can be stored in the disk of computer and carry out the real-time parameter analysis after changing through mould/number (A/D).
System can be according to pulse wave spectrum " figure place situation " theory, through to the time domain of signal, frequency domain and the time-the frequency conjoint analysis, again with built-in floating, heavy, number, late, basic arteries and veins graph parameters such as big, thin, string, cunning contrast, and can analyze " figure place situation " attribute of pulse-taking pressure signal.
(2) inspection of the tongue signal analysis submodule
The above-mentioned Tongue Information of system configuration is obtained recognition device, can absorb patient's tongue image pattern easily, software directly calls and controls the shooting of the digital inspection of the tongue image collecting device of colored high-resolution by the Windows api function, image imports computer into by USB or 1394 interfaces to be preserved.The doctor ticks the roughly square frame of tongue as the place with the form of man-machine interaction with mouse, and system can automatically identify leading indicators such as tongue body and tongue fur, size, color, after confirming or revise through the doctor, can participate in dialectical.The tongue image pattern sheet of collecting can be used as the important component part of electronic health record.
(3) inspection, inquiring submodule
Content of inquisition generally comprises: 1. ordinary circumstance: name, age, sex, address, prescription on individual diagnosis date etc.Native system provides the input system of above-mentioned ordinary circumstance, imports when patient's first visit; 2. main suit: the main suit is that patient feels painful symptom, sign when going to a doctor most.The main suit is the principal contradiction place of disease often, generally has only one, two disease, promptly is primary symptom.This software provides the input of maximum three primary symptoms; 3. the symptom of other except that the main suit: minor symptom has significant values too to the diagnosis of disease.This software provides the input of minor symptom, and quantity is not limit.
The order of inquiring module references in the medical history record " inquiring about ten aspects of patient song ", and be source with classical works such as typhoid fever, Medical Treasures of the Golden Chamber, Wenbing Tiaobian, Detailed Analysis of Epidemic Warm Diseases, compendium on epidemic febrile disease, single small stream heart methods, be divided into 21 big classes such as General Symptoms, women's head-ornaments portion, oropharynx, skin, extremity, cold and heat and antiperspirant, the heart, feelings will, taste, thirsty, stool, urine, breathing, expectorant, liver and gall, waist knee joint, male genetic, female reproduction, body of the tongue, tongue fur, pulse condition, be subdivided into some groups again under each big class.User only need use mouse to select corresponding symptom to describe and get final product, mistake and term lack of standardization when having avoided input.
System is divided into four kinds of main symptom, non-main symptom and picture of the tongue, pulse conditions with various symptoms, can import three kinds of symptoms when diagnosing each time at most as main symptom, and all the other are non-main symptom; Picture of the tongue is divided into body of the tongue again and resembles with tongue fur and resemble; Can import combination tongue picture and pulse condition.Input when system's built-in intelligence judgement system can be avoided conflicting symptom (for example rapid pulse cannot with slow pulse simultaneously and see).
Through reliability, repetition stability test proof, pulsation information of the present invention obtains recognition device and has following advantage:
(1) pulsation information obtains recognition device and has reliability: the result of Type B supersound extraction tremulous pulse morphological feature and color Doppler echocardiography does not have significant difference; Adopt different scanning angle (parallel and vertical), the vascular morphological characteristic basically identical that the Type B ultrasonic probe obtains.
(2) pulsation information obtains recognition device and has stability: the pressure pulse figure that same experimenter's different time is measured and the feature of ultrasonic Angiogram do not have significant difference.
(3) characteristic signal that obtains of pulsation information deriving means has repeatability: this experiment adopts manual method to measure, and analytical error is in allowed band.
(4) this device characteristic: 1. do not have wound, "dead".2. resolution height, the abundant information that obtains.3. can observe the radial artery dynamic motion changes.4. reliability, repeatability, stability etc. are functional.Obtaining recognition device with pulsation information is the center, obtains recognition device in conjunction with Tongue Information, and the present invention has realized objectifying of Diagnostics of Chinese Medicine comprehensive analysis of the data gained by the four methods of diagnosis, for extensive use clinically provides material base.
The experimental example pulsation information obtains recognition device reliability, repetition stability test
1. materials and methods
(1) the test equipment pulsation information obtains recognition device, and described computer is that desktop computer computer, described image collection card are SDK-2000 capture card, arteries and veins pillowcase.
(2) study subject entrance medical fitness, the four diagnostic methods do not have the Healthy Youth university students of significant discomfort, and the men and women half and half.
(3) experimental technique
The conventional instrument of opening makes the experimenter after quiet 10 minutes, seat abduction right arm, and straight wrist is faced upward the palm, is positioned over naturally on the wrist pillow.Same people's operation, rotation X, Y, Z axle knob are adjusted probe perpendicular to long axis direction, gently put and pop one's head in the area on the wrist over the radial artery where the pulse is felt for diagnosis radial artery top, do a labelling with permanent pen.Probe should be fully and preceding arm contact, do not exert pressure again and make blood vessel distortion.Under the intervention of ultrasonic coupling agent, start pulse condition collecting system, observed and recorded the area on the wrist over the radial artery where the pulse is felt for diagnosis radial artery real time kinematics situation of change.
1. failtests: the kinestate of blood vessel when writing down radial artery cross section and blood vessel longitudinal section simultaneously.During scanning radial artery cross section, the white marking point of the side of popping one's head in is perpendicular to long axis direction; During scanning radial artery longitudinal section, the white marking point of the side of popping one's head in is parallel to long axis direction.
2. stability experiment: advise the experimenter mark to be kept three days the cross section pulsation information of same radial artery GUAN spot time sheet.
(4) statistical method is all represented parameter value with x ± s, adopts the independent-samples T Test process of SPSS11.5 software.
2. result
(1) the normal ultrasonogram of radial artery shows that radial artery has the acoustic image characteristics of normal circumference blood vessel.The transverse axis tangent plane is circular echo, and the edge is regular, clear, and entrant sound is good, and the chamber wall of low echo area presents the variation of beating of relaxing and contracting.Longitudinal axis tangent plane is microscler echo, and the edge is regular, clear, and entrant sound is good, and the chamber wall of low echo area presents the variation of beating of relaxing and contracting.
(2) reliability testing result
Select 102 person-times of healthy volunteers for use, at 25.4 ± 7.2 years old age, special messenger's operation and analysis are measured the radial artery internal diameter and are also calculated changing value. and this pulsation information deriving means and color doppler flow imaging instrument are analyzed blood vessel cross section measurement result and are compared as follows (table 1):
Table 1 pulsation information obtains recognition device and the color doppler flow imaging instrument is analyzed blood vessel cross section result relatively (mean ± standard deviation)
Major diameter (mm) Minor axis (mm)
Minima Maximum Change Minima Maximum Change
This device Type B ultrasonoscopy color doppler flow imaging instrument image 2.22±0.52 1.63±0.42 2.76±0.51 2.49±0.67 0.54±0.20 0.88±0.42 1.97±0.47 1.64±0.49 2.39±0.48 2.47±0.37 0.42±0.12 0.81±0.11
P<0.05 ※※P<0.01
Produce SONOS-1500 type color doppler flow imaging instrument measurement result, there was no significant difference (P>0.05) with hewlette-packard.
(3) repeatable, Detection of Stability result
30 person-times of healthy volunteers, at 25.9 ± 7.9 years old age, radial artery internal diameter, the degree of depth and pressure eigenvalue are measured in the motion of three days radial artery of same experimenter's continuous record.The results are shown in Table 2,3,4:
Continuous three days pulsation information sampled result () (mean ± standard deviation) of the same experimenter of table 2
Index First day Second day The 3rd day
Main wave height (Pa) period of waves (ms) major diameter minima (mm) major diameter maximum (mm) minor axis minima (mm) minor axis maximum (mm) distance (mm) 9.03±0.38 413.41±15.52 2.39±0.07 2.69±0.04 2.30±0.04 2.62±0.07 2.27±0.10 9.68±0.18 424.27±6.40 2.45±0.06 2.73±0.07 2.36±0.04 2.65±0.11 2.22±0.07 9.47±0.27 437.84±5.46 2.35±0.06 2.64±0.07 2.25±0.09 2.47±0.09 2.27±0.10
P<0.05 ※※P<0.01
Continuous three days pulsation information sampled result (two) (mean ± standard deviation) of the same experimenter of table 3
Index First day Second day Third day
Main ripple (Pa) period of waves (ms) major diameter minima (mm) major diameter maximum (mm) minor axis minima (mm) minor axis maximum (mm) distance (mm) 14.64±0.33 347.34±5.15 1.74±0.10 2.60±0.02 1.53±0.10 1.76±0.06 2.80±0.02 13.73±0.245 355.39±1.52 1.74±0.06 2.73±0.03 1.66±0.07 2.00±0.04 2.48±0.10 14.15±0.89 344.40±11.01 1.75±0.08 2.58±0.06 1.60±0.08 2.00±0.09 2.44±0.14
P<0.05 ※※P<0.01
Continuous three days pulsation information sampled result (three) (mean ± standard deviation) of the same experimenter of table 4
Index First day Second day The 3rd day
Main wave height (Pa) period of waves (ms) major diameter minima (mm) major diameter maximum (mm) major diameter minima (mm) minor axis maximum (mm) distance (mm) 16.06±0.31 444.10±7.71 1.98±0.04 3.05±0.25 1.67±0.03 2.19±0.13 2.60±0.02 17.34±0.56 444.63±4.62 1.81±0.02 2.95±0.03 1.63±0.03 2.24±0.09 2.45±0.06 17.23±0.395 445.03±4.265 2.18±0.09 3.17±0.16 1.58±0.02 2.40±0.07 2.51±0.12
P<0.05 ※※P<0.01
Measured experimenter's radial artery motion leading indicator in continuous three days, the distance between right radial artery capitulum radii far away place and the skin, radial artery internal diameter major diameter, minor axis there are no significant difference (P>0.05); Main wave height under identical pulse pressure, period of waves, continuous three days no significant differences (P>0.05).Show that the instrument repetition stability is stronger.
Description of drawings:
Fig. 1 pulsation information obtains recognition device annexation figure
Fig. 2 pressure-B ultrasonic combined probe structure chart
Fig. 3 pressure-B ultrasonic combined probe pictorial diagram
Many physical quantitys of Fig. 4 synchronous acquisition real-time tracking system
Fig. 5 arterial pressure sphygmogram and Electrocardiographic ideograph
The comprehensive dialectical analysis of Fig. 6 interface
Fig. 7 pulsation information acquisition system principle schematic
Fig. 8 tongue inspection information harvester
The integral projection of Fig. 9 tongue body image R value
Tongue body after Figure 10 discerns automatically
Figure 11 inspection of the tongue automatization image processing flow chart
Figure 12 tongue figure information is obtained recognition device Facad structure figure
Figure 13 tongue figure information is obtained the recognition device construction profile
The sketch map of Figure 14 picture of the tongue checkout gear of the present invention and comprehensive analysis of the data gained by the four methods of diagnosis system
Among the figure: the 1st, pressure-B ultrasonic combined probe, the 2nd, B mode ultrasonic scanning instrument, the 3rd, Vetspecs-Toe/W photoelectricity volume sensor, the 4th, standard I I cardiac diagnosis lead, the 5th, microcomputer, the 6th, two-stage calculation amplifier, the 7th, video capture device, the 8th, video camera, the 9th, light source, the 10th, shade, the 11st, support, the 14th, the video data transmission equipment, the 13rd, data store analytical equipment, the 15th, camera lens, the 12nd, " nose standard " anchor point, the 16th, shutter release, the 17th, handle, the 18th, data wire power line, the 19th, on and off switch.
Describe the present invention below in detail and obtain recognition device
The specific embodiment
Embodiment 1: pulsation information obtains recognition device
This device mainly is made up of pressure-B ultrasonic combined probe 1, B mode ultrasonic scanning instrument 2, Vetspecs-Toe/W photoelectricity volume sensor 3, standard I I cardiac diagnosis lead 4, microcomputer 5; Standard I I cardiac diagnosis lead 4, Vetspecs-Toe/W photoelectricity volume sensor join through two-stage calculation amplifier 6 and desk computer 5, and B mode ultrasonic scanning instrument 2 links to each other with desk computer 5 by image pick-up card 7; Wherein pressure B ultrasonic combined probe by the B ultrasound probe 1., the sleeve of being made by metal material 2., elastica 3., transmitting medium 4., tracting pressuring hole 5., FSG-15 type pressure transducer 6., 7. sealing ring is formed, transmitting medium is 4. for there being the filling liquid of entrant sound effect, 1. B ultrasound pops one's head in, and the lower end is connected with B mode ultrasonic scanning instrument 2, B ultrasound probe 1. upper end inserts 2. upper end and 7. seal with sealing ring of sleeve, transmitting medium 4. be built in sealing ring 7. in, 3. elastica is fixed in sleeve lower end 2., with 2. lower end sealing of sleeve, 5. tracting pressuring hole is opened in a sleeve side 2., and 6. 5. tracting pressuring hole join with FSG-15 type pressure transducer.Described pressure transducer 6. parameter is as follows: working sensitivity: 0.25mV/grF; Response time: 1.0msec; Repeatability: ± 0.2%Span.The B mode ultrasonic scanning instrument parameter is as follows: operating frequency: 10MHz; Mechanical sector scan mode: mechanical sector scan; Resolution: vertical definition≤0.2mm; Transverse resolution≤0.4mm; Sweep limits: degree of depth 31mm~63mm; Frame frequency: 12 frame/seconds; GTG: 256 GTGs; Vernier certainty of measurement :≤0.25mm.
Embodiment 2: pulsation information obtains the method that recognition device obtains the identification pulsation information
Use embodiment 1 described device, 4. 1. the B ultrasound probe launched by the transmitting medium that the entrant sound effect is arranged and received ultrasound wave, shows the two-dimensional ct image (ultrasonograph figure) of tested tissue by B mode ultrasonic scanning instrument 2; Described ultrasonic signal is the video analog signal of standard, converts it to digital signal input desk computer 5 by video capture device 7 and handles;
The 3. stressed generation deformation of elastica changes the closed chamber internal pressure, 4. 5. passes to FSG-15 type pressure transducer 6. via tracting pressuring hole by airtight transmitting medium; 6. pressure transducer will send the preamplifier of being made up of two-stage calculation amplifier 6 input with scratching the pressure of the radial artery force signal that tremulous pulse cunkou pulse position contact acquisition by probe, and the outfan of preamplifier is imported desk computer 5 through interface, A/D converter and handled;
The preamplifier input that the signal that standard I I cardiac diagnosis lead 4, Vetspecs-Toe/W photoelectricity volume sensor 3 obtain is formed through two-stage calculation amplifier 6, the outfan of preamplifier is handled through interface, A/D converter input desk computer 5;
Desk computer 5 carries out data acquisition and interpretation of result by arteries and veins figure collection, analyzing software system.Pre-process circuit is to described pick off output pressure, photoelectricity volume and electrocardiosignal is amplified, filtering, improves the quality of signal, and it is transformed to the signal that is fit to Computer Processing.Provide interface between software and hardware by AduC812 type processor.The physiological signal data stream that obtains 12 precision passes through the output of UART port, after isolating (comprising isolated from power, signal isolation) safely, is converted to the USB1.0 signal and is sent to PC.
The described arteries and veins figure of technique scheme collection, analytical system are the software section that pulsation information obtains recognition device, development platform is Windows2000sxp and Visual Basic 6.0 sp6, operation platform is Windows2000, support that by the Access data base screen resolution is 1024 * 768.Window is with close friend's graphic interface operation and observation.Can between interfaces such as dynamic image acquisition, storage, playback, data analysis, switch easily by menu.
Data acquisition master interface: can show simultaneously from top to bottom that pressure of the radial artery is tried hard to, II leads electrocardiogram, finger tip photoelectricity volume diagram and radial artery B ultrasonic image 4 road signals.Radial artery B ultrasonic acoustic image identification figure observes radial artery motion, vessel cross-sections variation real-time tracking image under the B ultrasonic.Software can monitor and export synchronously radial artery pressure pulsation ripple, Artery Vein moving image automatically, refer to that terminal volume, standard I I lead electrocardiogram four road physiological signals.Automatically show static pressure, scalable pulse pressure in view of the above, floating when getting arteries and veins with the imitation traditional Chinese medical science, in, heavy maneuver.
The data analysis interface: by analyzing key, enter the data analysis interface at main interface, the data analysis interface has following function:
1. according to cardiac cycle, leading Electrocardiographic R ripple with II serves as that sign carries out arteries and veins figure cutting automatically;
2. identification automatically:
A is the arteries and veins source of graph.
B is arteries and veins figure (main ripple) peak.
C arteries and veins figure master's ripple and second minimum point (dicrotic notch) that makes progress between ripple.
The peak (dicrotic wave) of second ripple that makes progress behind the D arteries and veins figure master ripple.
The next arteries and veins source of graph of E.
3. calculate the also position of video data ECG (electrocardiogram) starting point automatically.
4. obtain A, B, C, D, 5 different probe X-axis of E, Y-axis data automatically.
5. calculate arteries and veins figure master ripple TW (main ripple is wide), MSAB (ascending branch greatest gradient) and MSBC (descending branch greatest gradient) automatically.
6. show pulse pressure automatically.
7. carry out the average of 30 arteries and veins figure automatically or by hand, extract minutiae through data transaction, repaints the pulse wave characteristic pattern.
Embodiment 3: the device that obtains visual pulsation information of identification and tongue inspection information
Obtaining recognition device and tongue inspection information by pulsation information obtains recognition device and forms.Wherein pulsation information obtains recognition device and mainly is made up of pressure-B ultrasonic combined probe 1, B mode ultrasonic scanning instrument 2, Vetspecs-Toe/W photoelectricity volume sensor 3, standard I I cardiac diagnosis lead 4, notebook computer 5; Standard I I cardiac diagnosis lead 4, Vetspecs-Toe/W photoelectricity volume sensor join through two-stage calculation amplifier 6 and notebook computer 5, and B mode ultrasonic scanning instrument 2 links to each other with notebook computer 5 by image pick-up card 7; Wherein pressure B ultrasonic combined probe by the B ultrasound probe 1., the sleeve of being made by metal material 2., elastica 3., transmitting medium 4., tracting pressuring hole 5., FSG-15 type pressure transducer 6., 7. sealing ring is formed, transmitting medium is 4. for there being the filling liquid of entrant sound effect, 1. B ultrasound pops one's head in, and the lower end is connected with B mode ultrasonic scanning instrument 2, B ultrasound probe 1. upper end inserts 2. upper end and 7. seal with sealing ring of sleeve, transmitting medium 4. be built in sealing ring 7. in, 3. elastica is fixed in sleeve lower end 2., with 2. lower end sealing of sleeve, 5. tracting pressuring hole is opened in a sleeve side 2., and 6. 5. tracting pressuring hole join with FSG-15 type pressure transducer.Described pressure transducer 6. parameter is as follows: working sensitivity: 0.25mV/grF; Response time: 1.0msec; Repeatability: ± 0.2%Span.The B mode ultrasonic scanning instrument parameter is as follows: operating frequency: 10MHz; Mechanical sector scan mode: mechanical sector scan; Resolution: vertical definition≤0.2mm; Transverse resolution≤0.4mm; Sweep limits: degree of depth 31mm~63mm; Frame frequency: 12 frame/seconds; GTG: 256 GTGs; Vernier certainty of measurement :≤0.25mm.
Tongue inspection information obtains recognition device by colour camera 8, light source 9, and the localized tongue image acquisition shade 10 of standardization, support 11, nose standard 12, notebook computer 13 is formed; Wherein light source 9 is around the camera lens of color video camera 8, the rear end of the localized tongue image acquisition shade 10 of external standardization; Support 11 is positioned at the fuselage lower end of video camera 8; Shade 10 front end top center have " nose standard " 12 anchor points; Colour camera 8 links to each other with notebook computer 13 by video data transmission equipment 14.Light source 9 is to have high-color rendering, even, stable be suitable for the miniature light sources that eurytopicity tongue figure gathers, and adopts annular light, colour temperature: 5200K, illumination: 5300Lum.Colour camera 1 is the CCD camera of the above resolution of 640*480.Support 11 adopts convenient, flexible imitative dental operation irradiation light stent-type photographic head bracing frame.Embodiment 4: the method for obtaining visual pulsation information of identification and tongue inspection information
Use embodiment 3 described devices, pulsation information obtains recognition methods: 4. 1. the B ultrasound probe launched by the transmitting medium that the entrant sound effect is arranged and received ultrasound wave, shows the two-dimensional ct image (ultrasonograph figure) of tested tissue by B mode ultrasonic scanning instrument 2; Described ultrasonic signal is the video analog signal of standard, converts it to digital signal input notebook computer 5 by video capture device 7 and handles;
The 3. stressed generation deformation of elastica changes the closed chamber internal pressure, 4. 5. passes to FSG-15 type pressure transducer 6. via tracting pressuring hole by airtight transmitting medium; 6. pressure transducer will send the preamplifier of being made up of two-stage calculation amplifier 6 input with scratching the pressure of the radial artery force signal that tremulous pulse cunkou pulse position contact acquisition by probe, and the outfan of preamplifier is imported notebook computer 5 through interface, A/D converter and handled;
The preamplifier input that the signal that standard I I cardiac diagnosis lead 4, Vetspecs-Toe/W photoelectricity volume sensor 3 obtain is formed through two-stage calculation amplifier 6, the outfan of preamplifier is handled through interface, A/D converter input notebook computer 5;
Notebook computer 5 carries out data acquisition and interpretation of result by arteries and veins figure collection, analyzing software system.Pre-process circuit is to described pick off output pressure, photoelectricity volume and electrocardiosignal is amplified, filtering, improves the quality of signal, and it is transformed to the signal that is fit to Computer Processing.Provide interface between software and hardware by AduC812 type processor.The physiological signal data stream that obtains 12 precision passes through the output of UART port, after isolating (comprising isolated from power, signal isolation) safely, is converted to the USB1.0 signal and is sent to PC.
The described arteries and veins figure of technique scheme collection, analytical system are the software section that pulsation information obtains recognition device, development platform is Windows2000sxp and Visual Basic 6.0 sp6, operation platform is Windows2000, support that by the Access data base screen resolution is 1024 * 768.Window is with close friend's graphic interface operation and observation.Can between interfaces such as dynamic image acquisition, storage, playback, data analysis, switch easily by menu.
Data acquisition master interface: can show simultaneously from top to bottom that pressure of the radial artery is tried hard to, II leads electrocardiogram, finger tip photoelectricity volume diagram and radial artery B ultrasonic image 4 road signals.Radial artery B ultrasonic acoustic image identification figure observes radial artery motion, vessel cross-sections variation real-time tracking image under the B ultrasonic.Software can monitor and export synchronously radial artery pressure pulsation ripple, Artery Vein moving image automatically, refer to that terminal volume, standard I I lead electrocardiogram four road physiological signals.Automatically show static pressure, scalable pulse pressure in view of the above, floating when getting arteries and veins with the imitation traditional Chinese medical science, in, heavy maneuver.
The data analysis interface: by analyzing key, enter the data analysis interface at main interface, the data analysis interface has following function:
1. according to cardiac cycle, leading Electrocardiographic R ripple with II serves as that sign carries out arteries and veins figure cutting automatically;
2. identification automatically:
A is the arteries and veins source of graph.
B is arteries and veins figure (main ripple) peak.
C arteries and veins figure master's ripple and second minimum point (dicrotic notch) that makes progress between ripple.
The peak (dicrotic wave) of second ripple that makes progress behind the D arteries and veins figure master ripple.
The next arteries and veins source of graph of E.
3. calculate the also position of video data ECG (electrocardiogram) starting point automatically.
4. obtain A, B, C, D, 5 different probe X-axis of E, Y-axis data automatically.
5. calculate arteries and veins figure master ripple TW (main ripple is wide), MSAB (ascending branch greatest gradient) and MSBC (descending branch greatest gradient) automatically.
6. show pulse pressure automatically.
7. carry out the average of 30 arteries and veins figure automatically or by hand, extract minutiae through data transaction, repaints the pulse wave characteristic pattern.
Tongue inspection information obtains the recognition methods of obtaining of recognition device: the picture of the tongue image that colour camera 8 is gathered is imported notebook computers 13 by video data transmission equipment 14, and notebook computer 13 carries out collection analysis by inspection of the tongue signals collecting and analysis module to the tongue inspection information that obtains.
Described inspection of the tongue signals collecting and analysis module comprise: GUI (pattern manipulation interface) submodule, data management submodule, tongue image acquisition and pretreatment submodule, picture of the tongue are handled and are analyzed submodule.By the GUI submodule, at first call the data management submodule and set up patient's electronic health record and expert info; Call tongue image acquisition and pretreatment submodule again, carry out collection and the pretreatment of tongue figure, and deposit pretreated tongue image in data base by the data management submodule; Call picture of the tongue then and handle and analyze submodule pretreated tongue figure, carry out tongue body cut apart with tongue as feature extraction, identification tongue fur, body of the tongue, sublingual vessel and dynamic image, and deposit the picture of the tongue feature of being extracted in data base by the data management submodule.
System has realized functions such as information typing, Flame Image Process and analysis, Information Statistics, data maintenance, report printing.
(1) the automatic analysis of picture of the tongue feature
The tongue Research of Dynamic Analysis adopts the moving object tracking algorithm, and the tongue shape feature analysis adopts the dividing method of tongue arteries and veins, is divided into Global Information analysis and local information analysis.
1. the Global Information analysis of tongue figure:
1) based on color characteristic: colour of the tongue, coating colour, thick fur, humidity, sublingual vein etc.
2) based on textural characteristics: curdy fur, greasy coating etc.
3) based on shape facility: plump tongue, thin tongue, swollen tongue, teeth-printed tongue etc.
4) based on behavioral characteristics: trembling tongue, askew partially tongue, cripetura tongue, strong tongue, soft tongue, wagging the tongue etc. wither
5) based on comprehensive characteristics: old tongue, tender tongue, red point, prickle, tongue fur be congruence partially.
6) based on the sublingual vessel feature: the width of sublingual vessel, length, color etc.
7) based on the behavioral characteristics of tongue: cripetura, chatter, crooked or the like.
2. the part of tongue figure or microscopic information analysis:
1) feature in primary part observation zone: the colour of the tongue of regional area, coating colour, thick fur, humidity, ecchymosis etc.
2) based on tongue map analysis---crackle, the tongue boil etc. of textural characteristics.
3) excrescent bulk area and form thereof on point (fungiform papillae), thorn (filiform papillae), ecchymosis, exfoliative fur, sublingual vein, the tongue.
The picture of the tongue feature is analyzed automatically, comprising:
1) under the acquisition condition of miniaturization, improves the analytical method of existing colour of the tongue, coating colour, thick fur, humidity.
2) analysis of picture of the tongue behavioral characteristics: for the sequence tongue image, merge based on video processing technique and multiple image, analyze the vibration of picture of the tongue, askew partially, cripetura, strong, wither soft, tell behavioral characteristics such as lane.
3) tongue shape attitude Feature Extraction and analysis: characteristics of image, the object geometry feature of whole or partial tongue shape attitude feature and tongue image all have relation.In the research image shape of object express and object between the describing method of structure, realize in fat big, thin thin, the swelling, indentation, pricking method, ecchymosis, flower stripping, sublingual vein, tongue of tongue morphological characteristic analyses such as vegetation on this basis.
4) general framework of research picture of the tongue feature extraction and analysis: carry out picture of the tongue Feature Extraction and analysis from the tongue diagram data, need make full use of the priori of Traditional Chinese Medicine experts.Be necessary to study the picture of the tongue feature extraction of knowledge elicitation and the general framework of analysis,, reduce blindness to improve the effectiveness of picture of the tongue feature analysis.Comprise: the tongue image Feature Extraction; Feature selection towards the picture of the tongue analysis; Many combination of features and extraction again; The quantification of picture of the tongue feature.
(2) picture of the tongue classification and the fusion of discerning
The way that solves is to adopt Feature Fusion.But the combination of different fusion features, different Feature Fusion influence bigger to classification and recognition result.Therefore need the feature selection of research picture of the tongue sample different characteristics (as geometry feature, characteristics of image, part/global characteristics) and optimization, Feature Fusion, and the Multiple Classifier Fusion that is applicable to the picture of the tongue sample.
(3) inspection of the tongue automatization image processing flow process
Mainly can divide into three phases: (1) low order is handled, and (2) scala media is handled, and (3) high-order is handled; Low order is handled and is inspection of the tongue image, sublingual vessel image capturing digitisation stage, and scala media is treated to the feature acquisition stage, and it then is the fuzzy analysis phase of last tongue feature and sublingual vessel feature that high-order is handled.
(4) function system characteristic
Be not subject to the environment light source influence; Can dynamically obtain the picture of the tongue image of complete display; But complete analysis picture of the tongue and tongue fur are related with the internal organs reaction zone; Can carry out the color texture feature analysis; Sublingual image quantitative analysis be can finish, audit report, medical history information storehouse quantized.
Embodiment 5: the method for obtaining visual pulsation information of identification and tongue inspection information
Use embodiment 3 described devices, pulsation information obtains recognition methods: 4. 1. the B ultrasound probe launched by the transmitting medium that the entrant sound effect is arranged and received ultrasound wave, shows the two-dimensional ct image (ultrasonograph figure) of tested tissue by B mode ultrasonic scanning instrument 2; Described ultrasonic signal is the video analog signal of standard, converts it to digital signal input notebook computer 5 by video capture device 7 and handles;
The 3. stressed generation deformation of elastica changes the closed chamber internal pressure, 4. 5. passes to FSG-15 type pressure transducer 6. via tracting pressuring hole by airtight transmitting medium; 6. pressure transducer will send the preamplifier of being made up of two-stage calculation amplifier 6 input with scratching the pressure of the radial artery force signal that tremulous pulse cunkou pulse position contact acquisition by probe, and the outfan of preamplifier is imported notebook computer 5 through interface, A/D converter and handled;
The preamplifier input that the signal that standard I I cardiac diagnosis lead 4, Vetspecs-Toe/W photoelectricity volume sensor 3 obtain is formed through two-stage calculation amplifier 6, the outfan of preamplifier is handled through interface, A/D converter input notebook computer 5;
Notebook computer 5 carries out data acquisition and interpretation of result by arteries and veins figure collection, analyzing software system.Pre-process circuit is to described pick off output pressure, photoelectricity volume and electrocardiosignal is amplified, filtering, improves the quality of signal, and it is transformed to the signal that is fit to Computer Processing.Provide interface between software and hardware by AduC812 type processor.The physiological signal data stream that obtains 12 precision passes through the output of UART port, after isolating (comprising isolated from power, signal isolation) safely, is converted to the USB1.0 signal and is sent to PC.
The described arteries and veins figure of technique scheme collection, analytical system are the software section that pulsation information obtains recognition device, development platform is Windows2000sxp and Visual Basic 6.0 sp6, operation platform is Windows2000, support that by the Access data base screen resolution is 1024 * 768.Window is with close friend's graphic interface operation and observation.Can between interfaces such as dynamic image acquisition, storage, playback, data analysis, switch easily by menu.
Data acquisition master interface: can show simultaneously from top to bottom that pressure of the radial artery is tried hard to, II leads electrocardiogram, finger tip photoelectricity volume diagram and radial artery B ultrasonic image 4 road signals.Radial artery B ultrasonic acoustic image identification figure observes radial artery motion, vessel cross-sections variation real-time tracking image under the B ultrasonic.Software can monitor and export synchronously radial artery pressure pulsation ripple, Artery Vein moving image automatically, refer to that terminal volume, standard I I lead electrocardiogram four road physiological signals.Automatically show static pressure, scalable pulse pressure in view of the above, floating when getting arteries and veins with the imitation traditional Chinese medical science, in, heavy maneuver.
The data analysis interface: by analyzing key, enter the data analysis interface at main interface, the data analysis interface has following function:
1. according to cardiac cycle, leading Electrocardiographic R ripple with II serves as that sign carries out arteries and veins figure cutting automatically;
2. identification automatically:
A is the arteries and veins source of graph.
B is arteries and veins figure (main ripple) peak.
C arteries and veins figure master's ripple and second minimum point (dicrotic notch) that makes progress between ripple.
The peak (dicrotic wave) of second ripple that makes progress behind the D arteries and veins figure master ripple.
The next arteries and veins source of graph of E.
3. calculate the also position of video data ECG (electrocardiogram) starting point automatically.
4. obtain A, B, C, D, 5 different probe X-axis of E, Y-axis data automatically.
5. calculate arteries and veins figure master ripple TW (main ripple is wide), MSAB (ascending branch greatest gradient) and MSBC (descending branch greatest gradient) automatically.
6. show pulse pressure automatically.
7. carry out the average of 30 arteries and veins figure automatically or by hand, extract minutiae through data transaction, repaints the pulse wave characteristic pattern.
Tongue inspection information obtains the recognition methods of obtaining of recognition device: the picture of the tongue image that colour camera 8 is gathered is imported notebook computers 13 by video data transmission equipment 14, and notebook computer 13 carries out collection analysis by inspection of the tongue signals collecting and analysis module to the tongue inspection information that obtains.
Described inspection of the tongue signals collecting and analysis module comprise: GUI (pattern manipulation interface) submodule, data management submodule, tongue image acquisition and pretreatment submodule, picture of the tongue are handled and are analyzed submodule.By the GUI submodule, at first call the data management submodule and set up patient's electronic health record and expert info; Call tongue image acquisition and pretreatment submodule again, carry out collection and the pretreatment of tongue figure, and deposit pretreated tongue image in data base by the data management submodule; Call picture of the tongue then and handle and analyze submodule pretreated tongue figure, carry out tongue body cut apart with tongue as feature extraction, identification tongue fur, body of the tongue, sublingual vessel and dynamic image, and deposit the picture of the tongue feature of being extracted in data base by the data management submodule.
System has realized functions such as information typing, Flame Image Process and analysis, Information Statistics, data maintenance, report printing.
(1) the automatic analysis of picture of the tongue feature
The tongue Research of Dynamic Analysis adopts the moving object tracking algorithm, and the tongue shape feature analysis adopts the dividing method of tongue arteries and veins, is divided into Global Information analysis and local information analysis.
1. the Global Information analysis of tongue figure:
1) based on color characteristic: colour of the tongue, coating colour, thick fur, humidity, sublingual vein etc.
2) based on textural characteristics: curdy fur, greasy coating etc.
3) based on shape facility: plump tongue, thin tongue, swollen tongue, teeth-printed tongue etc.
4) based on behavioral characteristics: trembling tongue, askew partially tongue, cripetura tongue, strong tongue, soft tongue, wagging the tongue etc. wither
5) based on comprehensive characteristics: old tongue, tender tongue, red point, prickle, tongue fur be congruence partially.
6) based on the sublingual vessel feature: the width of sublingual vessel, length, color etc.
7) based on the behavioral characteristics of tongue: cripetura, chatter, crooked or the like.
2. the part of tongue figure or microscopic information analysis:
1) feature in primary part observation zone: the colour of the tongue of regional area, coating colour, thick fur, humidity, ecchymosis etc.
2) based on tongue map analysis---crackle, the tongue boil etc. of textural characteristics.
3) excrescent bulk area and form thereof on point (fungiform papillae), thorn (filiform papillae), ecchymosis, exfoliative fur, sublingual vein, the tongue.
The picture of the tongue feature is analyzed automatically, comprising:
1) under the acquisition condition of miniaturization, improves the analytical method of existing colour of the tongue, coating colour, thick fur, humidity.
2) analysis of picture of the tongue behavioral characteristics: for the sequence tongue image, merge based on video processing technique and multiple image, analyze the vibration of picture of the tongue, askew partially, cripetura, strong, wither soft, tell behavioral characteristics such as lane.
3) tongue shape attitude Feature Extraction and analysis: characteristics of image, the object geometry feature of whole or partial tongue shape attitude feature and tongue image all have relation.In the research image shape of object express and object between the describing method of structure, realize in fat big, thin thin, the swelling, indentation, pricking method, ecchymosis, flower stripping, sublingual vein, tongue of tongue morphological characteristic analyses such as vegetation on this basis.
4) general framework of research picture of the tongue feature extraction and analysis: carry out picture of the tongue Feature Extraction and analysis from the tongue diagram data, need make full use of the priori of Traditional Chinese Medicine experts.Be necessary to study the picture of the tongue feature extraction of knowledge elicitation and the general framework of analysis,, reduce blindness to improve the effectiveness of picture of the tongue feature analysis.Comprise: the tongue image Feature Extraction; Feature selection towards the picture of the tongue analysis; Many combination of features and extraction again; The quantification of picture of the tongue feature.
(2) picture of the tongue classification and the fusion of discerning
The way that solves is to adopt Feature Fusion.But the combination of different fusion features, different Feature Fusion influence bigger to classification and recognition result.Therefore need the feature selection of research picture of the tongue sample different characteristics (as geometry feature, characteristics of image, part/global characteristics) and optimization, Feature Fusion, and the Multiple Classifier Fusion that is applicable to the picture of the tongue sample.
(3) inspection of the tongue automatization image processing flow process
Mainly can divide into three phases: (1) low order is handled, and (2) scala media is handled, and (3) high-order is handled; Low order is handled and is inspection of the tongue image, sublingual vessel image capturing digitisation stage, and scala media is treated to the feature acquisition stage, and it then is the fuzzy analysis phase of last tongue feature and sublingual vessel feature that high-order is handled.
(4) function system characteristic
Be not subject to the environment light source influence; Can dynamically obtain the picture of the tongue image of complete display; But complete analysis picture of the tongue and tongue fur are related with the internal organs reaction zone; Can carry out the color texture feature analysis; Sublingual image quantitative analysis be can finish, audit report, medical history information storehouse quantized.
In conjunction with Diagnostics of Chinese Medicine comprehensive analysis of the data gained by the four methods of diagnosis principle, configuration tcm diagnosis prescription system.This system is made up of (1) pulse-taking signal analysis submodule, (2) inspection of the tongue signal analysis submodule, (3) inspection inquiring submodule.This system uses Visual Studio Tm Ed Sft Dev AllLng L/SA Pk OLP NLAE w/MSDN Prm Qualified exploitation under Chinese Windows 2000/XP/2003.The operation hardware platform is PentiumIV 2.4GHz, the 1G internal memory, and monitor resolution is 1024 * 768, is furnished with the digital inspection of the tongue image collecting device of colored high-resolution, multiparameter pulse-taking harvester, tongue figure recognition system and pulse wave spectrum digitized detection system.The running software platform is Chinese Windows 2000/XP/2003 and SQL database system client.
(1) pulse-taking signal analysis submodule
In the diagnostic procedure, use above-mentioned pulsation information to obtain recognition device, can select to use ultrasonogram, pressure arteries and veins figure, photoelectricity arteries and veins figure and refer to modular diagnostic systems such as the volume arteries and veins figure interface of feeling the pulse, both can digital record patient pulse, can participate in dialectical again.Tradition is felt the pulse and is combined with modern technologies, and pulse-taking result dataization, standardization make the dialectical result of diagnosis more be tending towards objective.It wherein is example with the pressure signal, the pressure signal probe chip adopts up-to-date sensing element, the dynamic pressure of not only can the accurate recording pulse beating changes, and can synchronously write down the doctor and be added in static pressure on the pick off, thereby the simulation traditional Chinese medical science is pointed the process of feeling the pulse of " touching++++++++pressing and searching ", obtains the position attribution of " taking pulse lightly, moderately and heavily " of pulse condition.The analogue signal that collects can be stored in the disk of computer and carry out the real-time parameter analysis after changing through mould/number (A/D).
System can be according to pulse wave spectrum " figure place situation " theory, through to the time domain of signal, frequency domain and the time-the frequency conjoint analysis, again with built-in floating, heavy, number, late, basic arteries and veins graph parameters such as big, thin, string, cunning contrast, and can analyze " figure place situation " attribute of pulse-taking pressure signal.
(2) inspection of the tongue signal analysis submodule
The above-mentioned Tongue Information of system configuration is obtained recognition device, can absorb patient's tongue image pattern easily, software directly calls and controls the shooting of the digital inspection of the tongue image collecting device of colored high-resolution by the Windows api function, image imports computer into by USB or 1394 interfaces to be preserved.The doctor ticks the roughly square frame of tongue as the place with the form of man-machine interaction with mouse, and system can automatically identify leading indicators such as tongue body and tongue fur, size, color, after confirming or revise through the doctor, can participate in dialectical.The tongue image pattern sheet of collecting can be used as the important component part of electronic health record.
(3) inspection, inquiring submodule
Content of inquisition generally comprises: 1. ordinary circumstance: name, age, sex, address, prescription on individual diagnosis date etc.Native system provides the input system of above-mentioned ordinary circumstance, imports when patient's first visit; 2. main suit: the main suit is that patient feels painful symptom, sign when going to a doctor most.The main suit is the principal contradiction place of disease often, generally has only one, two disease, promptly is primary symptom.This software provides the input of maximum three primary symptoms; 3. the symptom of other except that the main suit: minor symptom has significant values too to the diagnosis of disease.This software provides the input of minor symptom, and quantity is not limit.
The order of inquiring module references in the medical history record " inquiring about ten aspects of patient song ", and be source with classical works such as typhoid fever, Medical Treasures of the Golden Chamber, Wenbing Tiaobian, Detailed Analysis of Epidemic Warm Diseases, compendium on epidemic febrile disease, single small stream heart methods, be divided into 21 big classes such as General Symptoms, women's head-ornaments portion, oropharynx, skin, extremity, cold and heat and antiperspirant, the heart, feelings will, taste, thirsty, stool, urine, breathing, expectorant, liver and gall, waist knee joint, male genetic, female reproduction, body of the tongue, tongue fur, pulse condition, be subdivided into some groups again under each big class.User only need use mouse to select corresponding symptom to describe and get final product, mistake and term lack of standardization when having avoided input.
System is divided into four kinds of main symptom, non-main symptom and picture of the tongue, pulse conditions with various symptoms, can import three kinds of symptoms when diagnosing each time at most as main symptom, and all the other are non-main symptom; Picture of the tongue is divided into body of the tongue again and resembles with tongue fur and resemble; Can import combination tongue picture and pulse condition.Input when system's built-in intelligence judgement system can be avoided conflicting symptom (for example rapid pulse cannot with slow pulse simultaneously and see).

Claims (10)

1. one kind is obtained the device of discerning pulsation information and tongue inspection information, it is characterized in that comprising that pulsation information obtains recognition device, this device mainly is made up of pressure-B ultrasonic combined probe 1, B mode ultrasonic scanning instrument 2, Vetspecs-Toe/W photoelectricity volume sensor 3, standard I I cardiac diagnosis lead 4, microcomputer 5, two-stage calculation amplifier 6 and video capture device 7; Wherein standard I I cardiac diagnosis lead 4, Vetspecs-Toe/W photoelectricity volume sensor 3 join with microcomputer 5 respectively through two-stage calculation amplifier 6, pressure-B ultrasonic combined probe 1 links to each other with B mode ultrasonic scanning instrument 2, and B mode ultrasonic scanning instrument 2 links to each other with microcomputer 5 by video capture device 7;
Wherein pressure B ultrasonic combined probe by B ultrasound probe 1., sleeve 2., elastica 3., transmitting medium 4., tracting pressuring hole 5., FSG one 15 type pressure transducers 6., 7. sealing ring form, 1. B ultrasound pops one's head in, and the lower end is connected with B mode ultrasonic scanning instrument 2, B ultrasound probe 1. upper end inserts 2. upper end and 7. seal with sealing ring of sleeve, transmitting medium 4. be built in sealing ring 7. in, 3. elastica is fixed in sleeve lower end 2., with 2. lower end sealing of sleeve, 5. tracting pressuring hole is opened in a sleeve side 2., and 6. 5. tracting pressuring hole join with FSG one 15 type pressure transducers; Tongue inspection information obtains recognition device mainly by colour camera 8, light source 9, and the localized tongue image acquisition shade 10 of standardization, support 11, nose standard 12, computer 13 is formed; Wherein light source 9 is around the camera lens of color video camera 8, the rear end of the localized tongue image acquisition shade 10 of external standardization; Support 11 is positioned at the fuselage lower end of video camera 8; Shade 11 front end top center have " nose standard " 12 anchor points; Colour camera 8 links to each other with computer 13 by video data transmission equipment 14.
2. the method for information is obtained in device identification as claimed in claim 1, it is characterized in that this method comprises the steps:
4. 1. the B ultrasound probe launched by the transmitting medium that the entrant sound effect is arranged and received ultrasound wave, shows the two-dimensional ct image of tested tissue by B mode ultrasonic scanning instrument 2; Described ultrasonic signal is the video analog signal of standard, converts it to digital signal input microcomputer 5 by video capture device 7 and handles; The 3. stressed generation deformation of elastica changes the closed chamber internal pressure, 4. 5. passes to FSG one 15 type pressure transducers 6. via tracting pressuring hole by airtight transmitting medium; 6. pressure transducer will send the preamplifier of being made up of two-stage calculation amplifier 6 input with scratching the pressure of the radial artery force signal that tremulous pulse cunkou pulse position contact acquisition by probe, and the outfan of preamplifier is imported microcomputer 5 through interface, A/D converter and handled; The preamplifier input that the signal that standard I I cardiac diagnosis lead 4, Vetspecs-Toe/W photoelectricity volume sensor 3 obtain is formed through two-stage calculation amplifier 6, the outfan of preamplifier is handled through interface, A/D converter input microcomputer 5; Microcomputer 5 carries out data acquisition and interpretation of result by arteries and veins figure collection, analyzing software system; The development platform of arteries and veins figure collection, analytical system is Windows2000sxp and Visual Basic 6.0sp6, and operation platform is Windows2000, supports that by the Access data base screen resolution is 1024 * 768; Window is with close friend's graphic interface operation and observation; Switch between interfaces such as dynamic image acquisition, storage, playback, data analysis by menu; Pulsation information data analysis interface is according to cardiac cycle, and leading Electrocardiographic R ripple with II serves as that sign carries out arteries and veins figure cutting automatically; Automatically discern the next arteries and veins source of graph of A starting point, B peak, C dicrotic notch, D dicrotic wave, E of arteries and veins figure; Automatically calculate the also position of video data ECG starting point; Automatically obtain A, B, C, D, 5 different probe X-axis of E, Y-axis data; Automatically calculate arteries and veins figure master ripple TW, MSAB and MSBC; Automatically show pulse pressure; Automatically or by hand carry out the average of 30 arteries and veins figure, extract minutiae through data transaction, is drawn the pulse wave characteristic pattern; The picture of the tongue image that colour camera 8 is gathered is imported computers 13 by video data transmission equipment 14, and computer 13 carries out collection analysis by inspection of the tongue signals collecting and analysis module to the tongue inspection information that obtains; Inspection of the tongue signals collecting and analysis module comprise: GUI submodule, data management submodule, tongue image acquisition and pretreatment submodule, picture of the tongue are handled and are analyzed submodule; By the GUI submodule, at first call the data management submodule and set up patient's electronic health record and expert info; Call tongue image acquisition and pretreatment submodule again, carry out collection and the pretreatment of tongue figure, and deposit pretreated tongue image in data base by the data management submodule; Call picture of the tongue then and handle and analyze submodule pretreated tongue figure, carry out tongue body cut apart with tongue as feature extraction, identification tongue fur, body of the tongue, sublingual vessel and dynamic image, and deposit the picture of the tongue feature of being extracted in data base by the data management submodule.
3. visual pulsation information and tongue inspection information obtain the integrated medical diagnostic equipment of recognition technology, it is characterized in that this diagnostic instruments comprises:
Pulsation information obtains identification division, comprises pressure-B ultrasonic combined probe, microcomputer, B mode ultrasonic scanning instrument, Vetspecs-Toe/W photoelectricity volume sensor, standard I I cardiac diagnosis lead; Wherein pressure B ultrasonic combined probe constitutes: 1. B ultrasound is popped one's head in, 2. sleeve, 3. elastica, 4. transmitting medium, 5. tracting pressuring hole, 6. FSG one 15 type pressure transducers; Sleeve is made by metal material, and the B ultrasound probe inserts its upper end and seals with sealing ring; Transmitting medium emission and the reception ultrasound wave of B ultrasound probe by the entrant sound effect is arranged, the two-dimensional ct image that shows tested tissue, built-in transmitting medium is a filling liquid, tracting pressuring hole is opened in a telescopic side, elastica is fixed in a telescopic end, with the sealing of sleeve lower end, the stressed generation deformation of elastica, the closed chamber internal pressure is changed, pass to pressure transducer via tracting pressuring hole by airtight transmitting medium; Pressure transducer detected pressures signal, be converted into signal of telecommunication output, FSG one 15 type pressure transducers send the preamplifier of being made up of the two poles of the earth operational amplifier input by probe with the pressure of the radial artery force signal of scratching the acquisition that tremulous pulse cunkou pulse position contacts, and the outfan of preamplifier couples together through interface, A/D converter, microcomputer and electrocardio pulse instrument;
Tongue inspection information obtains identification division, comprises the localized tongue image acquisition cover of standardization mouth; Chin rest; Dark slide; The high-res colour camera; Light source, light source has high-color rendering, even, stable is suitable for the miniature light sources that eurytopicity tongue figure gathers, adopt annular light, colour temperature: 5200K, illumination: 5300Lum, capture equipment is the above resolution of CCD camera: 640*480, and colored pick-up lens support Design is imitative dental operation irradiation light stent-type photographic head bracing frame.
4. medical diagnostic equipment as claimed in claim 3 is characterized in that this diagnostic instruments pressure transducer parameter is as follows: working sensitivity: 0.25mV/grF; Response time: 1.0msec; Repeatability: ± 0.2%Span.
5. medical diagnostic equipment as claimed in claim 3 is characterized in that this diagnostic instruments B mode ultrasonic scanning instrument parameter is as follows: operating frequency: 10MHz; Mechanical sector scan mode: mechanical sector scan; Resolution: vertical definition≤0.2mm; Transverse resolution≤0.4mm; Sweep limits: degree of depth 31mm~63mm; Frame frequency: 12 frame/seconds; GTG: 256 GTGs; Vernier certainty of measurement :≤0.25mm.
6. the method for visual automatic identification pulsation information and tongue inspection information is characterized in that this method comprises the steps:
The ultrasonic signal of pulsation information is the video analog signal of standard, convert it to digital signal by video capture device, pre-process circuit is to the pick off output pressure, photoelectricity volume and electrocardiosignal signal amplify, filtering, improve the quality of signal, and it is transformed to the signal that is fit to Computer Processing, provide interface between software and hardware by AduC812 type processor, the physiological signal data stream that obtains 12 precision is by the output of UART port, after the safety isolation, be converted to the USB1.0 signal and be sent to PC, pressure data that collects and B ultrasonic analysis result data are synchronous, and synthetic two-dimensional time change sequence figure, realization is the phase labelling method during with electrocardio, scratches the time synchronized and the position consistency analysis of the pressure pulse wave and the ultrasonic vascular image of arterial pulse wave; Make the distinctive collection of arteries and veins figure, analytical system;
Inspection of the tongue signals collecting and analysis comprise: GUI submodule, data management submodule, tongue image acquisition and pretreatment submodule, picture of the tongue are handled and are analyzed submodule, by the GUI submodule, at first call data management module and set up patient's electronic health record and expert info; Call tongue image acquisition and pretreatment submodule again, carry out collection and the pretreatment of tongue figure, and deposit pretreated tongue image in data base by the data management submodule; Call picture of the tongue then and handle and analyze submodule pretreated tongue figure, carry out tongue body cut apart with tongue as feature extraction, identification tongue fur, body of the tongue, sublingual vessel and dynamic image, and deposit the picture of the tongue feature of being extracted in data base by data management module.
7. the method for visual automatic identification pulsation information as claimed in claim 6 and tongue inspection information is characterized in that pulsation information data analysis interface is according to cardiac cycle in this method, and leading Electrocardiographic R ripple with II serves as that sign carries out arteries and veins figure cutting automatically; Automatically identification; Automatically calculate the also position of video data ECG starting point; Automatically obtain 5 different probe X-axis, Y-axis data; Automatically calculate arteries and veins figure master ripple TW, MSAB and MSBC; Automatically show pulse pressure; Automatically or by hand carry out the average of 30 arteries and veins figure, extract minutiae through data transaction, is drawn the pulse wave characteristic pattern.
8. the method for visual automatic identification pulsation information as claimed in claim 6 and tongue inspection information is characterized in that inspection of the tongue automatization step is divided into three phases in this method: low order is handled, and scala media is handled, and high-order is handled; Low order is handled and to be inspection of the tongue image, sublingual vessel image capturing digitisation stage, and scala media is treated to the spy and levies Screenshot and get the stage, and it then is the fuzzy analysis phase of last tongue feature and sublingual vessel feature that high-order is handled.
9. the method for visual automatic identification pulsation information as claimed in claim 6 and tongue inspection information, it is characterized in that the inspection of the tongue automated system disposes the digital inspection of the tongue image collecting device picked-up of colored high-resolution patient tongue image pattern in this method, software directly calls and controls the shooting of the digital inspection of the tongue image collecting device of colored high-resolution by the Windows api function, image imports computer into by USB or 1394 interfaces to be preserved.
10. the method for visual automatic identification pulsation information as claimed in claim 6 and tongue inspection information is characterized in that pulsation information and tongue inspection information information close the ginseng analytical system in this method to use VisualStudio Tm Ed Sft Dev All Lng L/SA Pk OLP NLAE w/MSDN Prm Qualified exploitation; The operation hardware platform is Pentium IV 2.4GHz, the 1G internal memory, and monitor resolution is 1024 * 768, is furnished with the digital inspection of the tongue image collecting device of colored high-resolution, multiparameter pulse-taking harvester, tongue figure recognition system and pulse wave spectrum digitized detection system; The running software platform is Chinese Windows2000/XP/2003 and SQL database system client.
CNA2007101513758A 2007-02-09 2007-10-08 Device and method for acquiring and recognizing pulsation information and tongue inspection information Pending CN101129261A (en)

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