CN101126737B - Cascade mass spectrometer for researching ionic reaction - Google Patents
Cascade mass spectrometer for researching ionic reaction Download PDFInfo
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- CN101126737B CN101126737B CN2007101443971A CN200710144397A CN101126737B CN 101126737 B CN101126737 B CN 101126737B CN 2007101443971 A CN2007101443971 A CN 2007101443971A CN 200710144397 A CN200710144397 A CN 200710144397A CN 101126737 B CN101126737 B CN 101126737B
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Abstract
The utility model relates to a cascade mass spectrometry for studying the ion reaction, comprising a linear quadrapole ion trap, a quadrapole quality analyzer is arranged at least one end of the linear quadrapole ion trap, an ion source which can produce a plurality of positive or anion flows is arranged at the other end of the quadrapole quality analyzer. The cascade mass spectrometry experimental system enables quality selection of the interested positive ions or anions firstly, and then the selected ions react with the other ions or numerators. Reaction product quality is analyzed and measured by the ion trap quality analyzer. The experimental system can also analyze the cascade mass spectrometry of interested positive ions or anions.
Description
(1) technical field
What the present invention relates to is that a kind of ionic reaction reaches the instrument that reactant is carried out quality analysis, relevant with mass spectrometer and analytical instrument.
(2) background technology
Mass spectrometer is a kind of scientific instrument that are used to analyze various chemical constitutions and content thereof.In mass spectrometer, quadrupole mass spectrometer is one of mass spectrometer of at present widespread use.It has simple in structure, and volume is less, characteristics such as uses and easy to operate.
Traditional quadrupole mass spectrometer is made up of four cylindrical electrodes, under the effect of additional power source, produces the Electric Field Distribution based on quadripolar electric field in four central areas that electrode surrounded.When the ion of different mass-to-charge ratioes during, under above-mentioned effect of electric field, have different movement locus by four central areas that electrode surrounded.What have can and be detected by follow-up ion detector by this zone, and what have will bump with electrode stem and disappear.In actual applications, by changing the AC and DC magnitude of voltage that is added on the quadrupole rod electrode regularly, allow the ion of different mass-to-charge ratioes be detected one by one by the quadrupole rod electrode system successively.Record also prints resulting ion signal, is needed mass spectrophotometry figure.
Four bar electrode also can be formed the quadrupole ion trap system, promptly so-called linear ion hydrazine.The effect of ion trap is to store and quality analysis etc. ion.The principle of four polar curve ion traps is to utilize the Electric Field Distribution based on quadrupole field that radio-frequency power supply produced be carried on four bar electrode equally, and realization is evicted from the storage of ion and selectivity etc.
Therefore, quadrupole rod mass spectrum and linear quadrupole ion trap are combined, might realize selection, functions such as storage and quality analysis ion.Satisfy the needs of scientific research and engineering.
(3) summary of the invention
The purpose of this practicality invention is to provide a kind of can carry out quality selection, reaction to ion, and can carry out the cascade mass spectrometer of a kind of researching ionic reaction of quality analysis measurement to reaction product.
The object of the present invention is achieved like this: it comprises linear quadrupole ion trap, at least one end of linear quadrupole ion trap the quadrupole rod mass analyzer is set, and just can produce in the other end setting of quadrupole rod mass analyzer/ion gun of negative ion stream.
The present invention can also comprise some architectural features like this:
1, at the two ends of linear quadrupole ion trap the quadrupole rod mass analyzer is set respectively, the ion gun that can produce positive and negative ion stream is set respectively at the other end of each quadrupole rod mass analyzer.
2, be provided with ion detector in the both sides of linear quadrupole ion trap.
The present invention proposes a kind of ion-ionic reaction that can be used for studying, the cascade mass spectrometer experimental system of ion-molecule reaction.Its experimental system mainly comprises: 1), two ion guns are used to produce two kinds of ion flows that are used for chemical reaction research usefulness, as positive ion stream and negative ion stream.2), two quadrupole mass spectrometers are used for the ion that Selective Separation goes out two kinds of research usefulness.3), a linear quadrupole ion trap device is used for the ion that quadrupole rod is selected is stored, and makes different ion-interionics, or chemical reaction takes place between heteroion.Another function of ion trap is further the product that chemical reaction produced to be carried out mass spectrophotometry.Obtain the kind and the content information of chemical reaction product.4), ion detector is used to write down ion signal.5), vacuum system is used to the experiment of each part mentioned above that vacuum environment is provided.With 6), experiment control and data recording, disposal system.
Use this tandem mass spectrometry experimental system, can at first carry out the quality selection, and then allow these ions of selecting and other lewis' acids react interested positive ion or negative ion.Reaction product is carried out quality analysis by ion strap mass analyzer and is measured.The experimental system that the present invention provides can also be carried out cascade mass spectrometry to interested positive ion or negative ion.
The present invention also can once only use an ion gun to produce a kind of ion, and then use a quadrupole rod mass analyzer to select a kind of ion, and be stored in the ion trap, then, certain interested neutral molecule is incorporated in the ion trap, make it with ion trap in ion generation chemical reaction.Similarly, use the content of ion trap analyzing and testing reaction product and various products at last.
(4) description of drawings
Fig. 1 is a theory structure synoptic diagram of the present invention;
Fig. 2 is the synoptic diagram of experimental provision of the present invention.
(5) embodiment
For example the present invention is done description in more detail below in conjunction with accompanying drawing:
In conjunction with Fig. 1, the composition of the cascade mass spectrometer of researching ionic reaction comprises linear quadrupole ion trap 15, end in linear quadrupole ion trap is provided with quadrupole rod mass analyzer 13, can produce the ion gun 11 of positive ion stream in the other end setting of quadrupole rod mass analyzer 13, the other end in linear quadrupole ion trap is provided with quadrupole rod mass analyzer 14, other end setting at quadrupole rod mass analyzer 14 can produce the ion gun 12 that positive ion flows, and is provided with ion detector 16,17 in the both sides of linear quadrupole ion trap.
Wherein 11,12 is two ion guns that can produce negative ions stream.13 and 14 for being used for respectively just being produced by ion gun 11,12, and negative ion carries out the quadrupole rod mass analyzer of quality Selective Separation.15 is linear quadrupole ion trap, its effect is just to go out by the quadrupole rod mass analyzer is selected, and negative ion is stored, and provides the environment that chemical reaction takes place for them, with reaction product is carried out quality analysis, obtain the information of chemical reaction product and content.16 and 17 for being placed in two ion detectors on ion trap both sides, is used for ion surveyed with signal amplifying.
Also can once only use an ion gun to produce a kind of ion, and then use a quadrupole rod mass analyzer to select a kind of ion, and be stored in the ion trap, then, certain interested neutral molecule is incorporated in the ion trap, make it with ion trap in ion generation chemical reaction.Similarly, use the content of ion trap analyzing and testing reaction product and various products at last.
In conjunction with Fig. 2, it is an one embodiment of the present invention.The ion flow 21 that is produced by ion gun enters into quadrupole rod mass analyzer 23 and makes quality and select behind electrode 22.The 24th, by the selected ion with single mass-to-charge ratio that comes out of quadrupole rod mass analyzer 23, it is gone in the linear quadrupole ion trap 27 by aperture 25 is laggard.The 26th, the vacuum cavity of linear quadrupole ion trap is installed, the effect of this vacuum cavity is can introduce some gases to the ion trap zone, and keep air pressure high relatively in this zone.Air pressure can have two effects, and the one, during as ion-ionic reaction, higher air pressure can collide cooling to the ion of storage.The 2nd, when reacting, can introduce reacting gas to ion trap as ion-neutral molecule.Higher air pressure can be so that chemical reaction be easier to take place, and obtains more reaction product.There are two apertures 25 and 30 in 26 two ends, and the effect of aperture is to allow ion enter in the ion trap.35 is the ion flow that has the another one ion gun to be produced, and this ion flow is done the quality selection through entering into another quadrupole rod mass analyzer 33 behind electrode 34.The 32nd, by the selected ion with single mass-to-charge ratio that comes out of quadrupole rod mass analyzer 33, it is introduced by ion, and aperture 30 on the electrode 31 is laggard goes in the linear quadrupole ion trap 27.Generally, the electric polarity of ion flow 21 and ion flow 35 is opposite, and promptly when ion flow 21 was positive ion, then ion flow 35 was negative ion stream.Or 21 be negative ion, and 35 is positive ion.Therefore, the ion 24 and 35 after quality is selected, its electric polarity is also inequality.Even 24 is positive ion, and then the ion 32 after quality is selected should be negative ion.When ion 24 and ion 32 are stored in the ion trap 27 simultaneously, collision and chemical reaction mutually will take place in them.Experimentally, can also be by regulating the chemical time that ion changes two kinds of ions the storage time in ion trap.The product of chemical reaction, and the content of various products is done quality analysis by ion trap 27.Ion signal ion detector 28,29 again detects.Ion detector can be one, also can be two.Obviously, when using two ion detectors, resulting signal intensity can be bigger.On the other hand, use two ion detectors can increase the instrument manufacturing cost.
When this experimental system is used to study ion-molecule reaction.Only need to use an ion gun, quadrupole rod mass analyzer and ion trap are just.For example, when research certain positive ion-molecular reaction, produce positive ion stream 21, make quality by quadrupole rod mass analyzer 23 then and select by ion gun.Ion 24 after quality is selected enters ion trap 27 and is stored.Simultaneously, the neutral molecule of need research is incorporated in the ion trap 27, makes it and the ion stored reacts.Similarly, the product of chemical reaction, and the content of various products is done quality analysis by ion trap 27.Ion signal ion detector 28,29 again detects.
When research negative ion-molecular reaction, used method and process are identical with research positive ion-molecular reaction.
Sometimes need in ion gun and quadrupole rod mass analyzer, settle ion-optic system, so that ion transmission efficiency to be provided, or be convenient to the work of vacuum system.Though but whether use ion-optic system, the basic function of the given system of the present invention do not influenced.
Generally speaking, ion-optic system, mass of ion analyzer and ion detector all must be worked under the vacuum condition again.Ion gun is also inequality according to the different desired vacuum condition of its kind.The ion gun that has requires to be operated under the vacuum condition, as electron impact ionization ion gun etc.The ion gun that has also can be operated under the atmospheric pressure, as electron spray ionisation ion gun etc.
Claims (1)
1. the cascade mass spectrometer of a researching ionic reaction, it comprises linear quadrupole ion trap, vacuum cavity, first electrode (22), second electrode (34), the first quadrupole rod mass analyzer (23), the second quadrupole rod mass analyzer (33), just can produce/ion gun and two ion detectors of negative ion stream, it is characterized in that: the positive ion stream (21) that is produced by the ion gun that can produce positive ion stream enters into the first quadrupole rod mass analyzer (23) and makes quality and select behind first electrode (22), the selected positive ion with single mass-to-charge ratio (24) that comes out is gone into linear quadrupole ion trap by first aperture (25) is laggard, linear quadrupole ion trap is installed in vacuum cavity inside, the effect of this vacuum cavity is, can introduce some gases to the ion trap zone, and keep this zone in relative high pressure, air pressure can have two effects, the one, during as ion-ionic reaction, higher air pressure can collide cooling to the ion of storage; The 2nd, when reacting, can introduce reacting gas to ion trap as ion-neutral molecule, the vacuum cavity two ends are respectively arranged with first aperture (25) and second aperture (30), and the effect of aperture is to allow ion enter in the ion trap; The negative ion stream (35) that is produced by the ion gun that can produce negative ion stream enters into the second quadrupole rod mass analyzer (33) and makes quality and select behind second electrode (34), the selected negative ion with single mass-to-charge ratio (32) that comes out is gone into linear quadrupole ion trap by second aperture (30) is laggard, positive ion (24) and negative ion (32) are stored in simultaneously, and collision and chemical reaction mutually take place in the linear quadrupole ion trap, the product of chemical reaction and the content of various products are done quality analysis by linear quadrupole ion trap, ion signal is detected by two ion detectors, and two ion detectors are installed in the both sides of linear quadrupole ion trap respectively.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2007101443971A CN101126737B (en) | 2007-09-29 | 2007-09-29 | Cascade mass spectrometer for researching ionic reaction |
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| CN2007101443971A CN101126737B (en) | 2007-09-29 | 2007-09-29 | Cascade mass spectrometer for researching ionic reaction |
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| CN101126737A CN101126737A (en) | 2008-02-20 |
| CN101126737B true CN101126737B (en) | 2011-03-16 |
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Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102169791B (en) * | 2010-02-05 | 2015-11-25 | 岛津分析技术研发（上海）有限公司 | A kind of cascade mass spectrometry device and mass spectrometric analysis method |
| CN102163531B (en) * | 2011-03-10 | 2013-01-09 | 中国科学院合肥物质科学研究院 | Flat line type ion trap mass analyzer based on MEMS (micro electro mechanical system) process and manufacturing method thereof |
| CN102760635B (en) * | 2012-03-31 | 2015-01-07 | 清华大学 | H-type array ion trap and method for carrying out ion-ion reaction in trap |
| CN103681208B (en) * | 2013-12-10 | 2016-03-23 | 中国科学院化学研究所 | The quadrupole rod quality analysis apparatus of the two-way introducing of a kind of ion and transmission |
| US10163618B2 (en) * | 2015-11-19 | 2018-12-25 | National Institute Of Metrology China | Mass spectrometry apparatus for ultraviolet light ionization of neutral lost molecules, and method for operating same |
| TWI693625B (en) * | 2017-05-09 | 2020-05-11 | 譜光儀器股份有限公司 | Quadrupole ion trap device and quadrupole ion trap mass spectrometer |
| CN108956751B (en) * | 2018-06-28 | 2021-08-17 | 中国计量科学研究院 | Method for measuring distance between gas phase molecular sites |
| CN109003875B (en) * | 2018-08-08 | 2019-12-20 | 清华大学 | Mass spectrum tissue analysis instrument based on tandem mass spectrum and use method thereof |
| CN109239175B (en) * | 2018-08-15 | 2023-10-03 | 金华职业技术学院 | Method for detecting macromolecular ions |
| CN111199866B (en) * | 2018-11-20 | 2020-11-24 | 中国科学院大连化学物理研究所 | Universal light ionization source for positive and negative ions |
| CN112420479B (en) * | 2020-11-16 | 2023-08-04 | 宁波大学 | Miniature mass spectrometer |
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