CN101121672A - Betaine phosphate and its producing method and applicaiton - Google Patents
Betaine phosphate and its producing method and applicaiton Download PDFInfo
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- CN101121672A CN101121672A CNA2006100298425A CN200610029842A CN101121672A CN 101121672 A CN101121672 A CN 101121672A CN A2006100298425 A CNA2006100298425 A CN A2006100298425A CN 200610029842 A CN200610029842 A CN 200610029842A CN 101121672 A CN101121672 A CN 101121672A
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- betaine phosphate
- betaine
- phosphate
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- trimethylamine
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Abstract
The invention relates to a solid betaine phosphate product. The application of the product of the invention is superior to the betaine hydrochloride; the cost of the product is low; the product can be used to improve the nutrition structure of the animal when used in the feed additives; in addition, the product can still be used in the cosmetics, food and medicines. The invention provides a preparation method.
Description
Technical field
The present invention relates to trimethyl-glycine, particularly a kind of betaine phosphate.
Background technology
Trimethyl-glycine (Betaine) at first is found in Europe, and it mainly is present in the molasses of beet sugar, so gain the name.Since nineteen thirty-nine D.U.Vigneaud finds its trophic function, trimethyl-glycine becomes people's research focus always, and is widely used in fields such as pharmacy, food, additive, chemical reagent, industrial chemicals, livestock and poultry cultivation, aquaculture, biological fermentation.
Trimethyl-glycine is the methylated amino acid of N-, has important function in the animal and plant metabolism, and it has following structural:
Trimethyl-glycine has two electrode structures, and it contains three active methyls, and these methyl can participate in enzymic catalytic reaction.Trimethyl-glycine can be used as fodder additives or foodstuff additive, when running into abominable physical environment, can also be as the growth improving agent of plant, can also be used for fertilizer, makeup, medicine or foodstuffs industry, and and can in amino acid production, antibiotic medicine production, removing mildew production, be used as the biological fermentation auxiliary agent.
The trimethyl-glycine of Shi Yonging mainly contains trimethyl-glycine inner salt (1), trimethyl-glycine monohydrate (2) and (3) three kinds of products of beet alkali hydrochlorate in the market:
Because the production cost of trimethyl-glycine inner salt and trimethyl-glycine monohydrate is higher, it is substituted by the relatively low beet alkali hydrochlorate of cost gradually in Application for Field such as additive, livestock and poultry cultivation, aquaculture, biological fermentations, and the market share of beet alkali hydrochlorate has accounted for more than 80% of all products of trimethyl-glycine.It is acid that but beet alkali hydrochlorate shows, and the existence of chlorion also makes this product at the too late trimethyl-glycine inner salt of Application for Field effects such as additive, livestock and poultry cultivation, aquaculture, biological fermentation.
Summary of the invention
Technical problem to be solved by this invention is to overcome above-mentioned weak point, a kind of more effective beet alkali salt of research and design.
The invention provides a kind of betaine phosphate, as shown in the formula:
Molecular formula: C
5H
14NO
6P
Molecular weight: 215.14
Physicals: white is little yellow crystalline powder extremely, odorlessness, and sour-puckery flavor, the tool moisture absorption, very easily water-soluble, be dissolved in ethanol.
The present invention uses the phosphate anion (H favourable to growth of animal
2SO
4 -) replacement chlorion (Cl
-Thereby) making betaine phosphate, this production cost of products is not high, has improved the result of use of trimethyl-glycine simultaneously again.
Phosphorus (P) is the necessary mineral element of animal, plays a part crucial at bone and the tooth development of animal and in keeping; Simultaneously, phosphorus is the fundamental element in all cells and the cytolemma, and it participates in constituting the structural material of viable cell, has constituted the skeleton of DNA and RNA molecule, participates in the transmission of genetic information; Phosphoric acid salt is being played the part of very important role in the daily energy exchange of cell, it participates in the synthetic and catabolism of nearly all important organic substance; High-energy phosphate compound then plays a part very important in release, storage and the utilization of energy; Phosphorus is again to keep acid base equilibrium and the important substance of regulating osmotic pressure in the body.
Another object of the present invention has provided the preparation method of betaine phosphate.
The preparation method 1:
In the water that this method is dissolved in equivalent with the trimethyl-glycine and the phosphoric acid of equivalent, leave standstill crystallization, filter, dry betaine phosphate.
The preparation method 2:
This method is made into Mono Chloro Acetic Acid the aqueous solution of 20-40%, place reactor, start stirring, be neutralized to pH4.0-5.0 with the aqueous sodium hydroxide solution of 15-30% or yellow soda ash and make sodium chloroacetate solution, be cooled to 10-30 ℃ then, add the trimethylamine aqueous solution of 25-40% or feed Trimethylamine 99 gas, the mol ratio of sodium chloroacetate and Trimethylamine 99 is 1: 1.00-1.20, controlled temperature reacted 5-7 hour at 30-60 ℃.Reaction solution takes advantage of heat filtering to remove most of sodium-chlor after concentrating.Transfer pH to 2.0-2.5 with the phosphoric acid of 30-85%, crystallisation by cooling filters, and gets betaine phosphate.
In view of above-mentioned principle, betaine phosphate can play the cooperative effect of trimethyl-glycine and phosphorus in application process, thereby, betaine phosphate and betaine phosphate composition series product are better than beet alkali hydrochlorate as the effect of animal feedstuff additive, not only feed cost can be reduced, also the Animal nutrition structure can be improved.
Except that above-mentioned application, betaine phosphate and the effect of betaine phosphate composition series product in makeup or toiletry also are better than beet alkali hydrochlorate, reduce the pungency side effect of chlorion in the product, improved the trophic function of makeup; Betaine phosphate and the effect of betaine phosphate composition series product in medicine also are better than beet alkali hydrochlorate; Betaine phosphate and betaine phosphate composition series product are better than beet alkali hydrochlorate in the Application in Food effect, not only improve food nutrient structure, also improve the taste of food; Betaine phosphate and betaine phosphate composition series product can also be applied to aspects such as amino acid production, antibiotic medicine production, zymin production as fermentation assistant.
Embodiment
Embodiment:
Embodiment 1: 125 gram trimethyl-glycines are dissolved in the 100ml water and make solution, slowly drip 85% phosphoric acid and transfer pH to 2.0-2.5, leave standstill crystallization, filter, filtrate is applied mechanically, and the crystallization oven dry just gets betaine phosphate.
Embodiment 2: agitator is being housed, and gas absorbing device in the 1000ml four-hole bottle of thermometer, adds entry 160g, with the oil bath heating, drives agitator, adds 99% Mono Chloro Acetic Acid 100g, makes it to dissolve fully.Drip the neutralization of 30% aqueous sodium carbonate, terminal point pH4.0-5.0.Neutralizer is cooled to 25 ℃ with cold water, slowly feeds the about 64g of Trimethylamine 99, and controlled temperature is at 30-80 ℃, and about 6 hours of stirring reaction, reaction solution take advantage of heat filtering to remove most of sodium-chlor after being concentrated into 1/2nd volumes.Transfer pH to 2.0-2.5 with the phosphoric acid of 30-85%, crystallisation by cooling filters, and filter cake washes afterwards following batch of mother liquor with water and applies mechanically, and crystallizing and drying gets the pure product of betaine phosphate, and purity is greater than 98.0%, yield 92%.
Embodiment 3: adopt the same step of embodiment 1, only be to use 35% trimethylamine aqueous solution to replace Trimethylamine 99 gas, operation index is constant, obtains beet alkali content at last greater than 98%, yield 90%.
Embodiment 4: adopt the same step of embodiment 1, only be to use 20% aqueous sodium hydroxide solution to replace 30% aqueous sodium carbonate, operation index is constant, obtains beet alkali content at last greater than 98%, yield 93%.
Claims (8)
1. betaine phosphate is characterized in that it has following array structure and performance:
Molecular formula: C
5H
14NO
6P
Molecular weight: 215.14
Physicals: white is little yellow crystalline powder extremely, odorlessness, and sour-puckery flavor, the tool moisture absorption, very easily water-soluble, be dissolved in ethanol.
2. the preparation method of an a kind of betaine phosphate as claimed in claim 1 is characterized in that leaving standstill crystallization in the water that this method is dissolved in equivalent for trimethyl-glycine and phosphoric acid with equivalent, filters, dry betaine phosphate.
3. the preparation method of an a kind of betaine phosphate as claimed in claim 1, it is characterized in that this method is for being made into Mono Chloro Acetic Acid the aqueous solution of 20-40%, place reactor, start stirring, be neutralized to pH 4.0-5.0 with the aqueous sodium hydroxide solution of 15-30% or yellow soda ash and make sodium chloroacetate solution; Be cooled to 10-30 ℃ then, add the trimethylamine aqueous solution of 25-40% or feed Trimethylamine 99 gas, the mol ratio of sodium chloroacetate and Trimethylamine 99 is 1: 1.00-1.20, controlled temperature reacted 5-7 hour at 30-60 ℃; Reaction solution takes advantage of heat filtering to remove sodium-chlor after concentrating, and transfers pH to 2.0-2.5 with the phosphoric acid of 30-85%, and crystallisation by cooling filters, and gets betaine phosphate.
4. a betaine phosphate as claimed in claim 1 is as the application for preparing animal feedstuff additive.
5. the application of betaine phosphate as claimed in claim 1 in makeup or toiletry.
6. a betaine phosphate as claimed in claim 1 is in Application in Food.
7. the application of betaine phosphate as claimed in claim 1 in medicine.
A betaine phosphate as claimed in claim 1 as fermentation assistant at amino acid, antibiotic medicine, the application during zymin is produced.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2006100298425A CN101121672B (en) | 2006-08-09 | 2006-08-09 | Betaine phosphate and its producing method and applicaiton |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2006100298425A CN101121672B (en) | 2006-08-09 | 2006-08-09 | Betaine phosphate and its producing method and applicaiton |
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|---|---|
| CN101121672A true CN101121672A (en) | 2008-02-13 |
| CN101121672B CN101121672B (en) | 2010-11-24 |
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| CN2006100298425A Active CN101121672B (en) | 2006-08-09 | 2006-08-09 | Betaine phosphate and its producing method and applicaiton |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102917788A (en) * | 2010-03-23 | 2013-02-06 | 罗迪亚运营公司 | Continuous method for manufacturing betaine aqueous solution |
| CN107573253A (en) * | 2017-10-25 | 2018-01-12 | 广州英赛特生物技术有限公司 | N, N dimethylglycine organic acid conjugation hydrochlorate and combinations thereof and application |
| CN110192655A (en) * | 2019-04-28 | 2019-09-03 | 上海共晶医药科技有限公司 | A kind of microballoon of alpha-tocopherol and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1163827A (en) * | 1956-04-20 | 1958-10-01 | Process for the preparation of phosphates, betaine acetylmethionate ascorbate |
-
2006
- 2006-08-09 CN CN2006100298425A patent/CN101121672B/en active Active
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102917788A (en) * | 2010-03-23 | 2013-02-06 | 罗迪亚运营公司 | Continuous method for manufacturing betaine aqueous solution |
| CN102917788B (en) * | 2010-03-23 | 2015-09-02 | 罗迪亚运营公司 | Prepare the continuation method of aqueous solutions of betaine |
| CN107573253A (en) * | 2017-10-25 | 2018-01-12 | 广州英赛特生物技术有限公司 | N, N dimethylglycine organic acid conjugation hydrochlorate and combinations thereof and application |
| CN110192655A (en) * | 2019-04-28 | 2019-09-03 | 上海共晶医药科技有限公司 | A kind of microballoon of alpha-tocopherol and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101121672B (en) | 2010-11-24 |
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Address after: 262737 Shandong city of Weifang province Lingang Industrial Park, Binhai Economic Development Zone, Binhai Avenue No. 0199 Patentee after: SHANDONG SUNWIN BIOTECHNOLOGY CO., LTD. Address before: 262737 Shandong city of Weifang province Lingang Industrial Park, Binhai Economic Development Zone, Binhai Avenue No. 0199 Patentee before: Shandong Sunwin Biotechology Co., Ltd. |