CN101120792A - Method for manufacturing beverage containing antioxidant ingredients substance - Google Patents
Method for manufacturing beverage containing antioxidant ingredients substance Download PDFInfo
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- CN101120792A CN101120792A CNA2006101121051A CN200610112105A CN101120792A CN 101120792 A CN101120792 A CN 101120792A CN A2006101121051 A CNA2006101121051 A CN A2006101121051A CN 200610112105 A CN200610112105 A CN 200610112105A CN 101120792 A CN101120792 A CN 101120792A
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Abstract
The present invention relates to an anti-oxidation substance which has the functions of anti-senility, anticancer, anti-disease, protection cells and improving vision, and can be drunk or eaten as drink or food and the manufacturing method. Anti-oxygen compound or anti-oxygen salt based on a certain ratio is added into the drink or food, a certain quantitative drink or food has the following effective elements with proper quantity: vitamin C (water solubility), Beta-carotenes (oil solubility), lycopene (oil solubility), lutein (oil solubility) and surfactant additive. The drinks or food, seeing from the body absorption effect or biochemical effect, have no side effect, but has more free radical removing effect.
Description
Technical field
The present invention relates to contain in a kind of Foods or drinks anti-ageing, anticancer, anti-disease, protection cell, strengthen antioxidant content material such as eyesight, particularly about oozing the drink that water-soluble vitamin c constitutes or the method for food and manufacturing thereof of being mixed with in the oil-soluble carotenoid antioxidant.
Background technology
The present various antioxidants of human intake; must rely on food, nutraceutical or the medicine of nature to go picked-up edible individually, in fact its oxidation resistant greatest benefit can't bring into play anti-ageing, anticancer, anti-disease, protection cell, strengthen effect such as eyesight and obtain best achievement.
Known each antioxidant is to the benefit of human body, for example:
1. lutein (Lutein) is a kind of in oil-soluble carotenoid, natural be present in bottle green leaf vegetables spinach, Brussels sprouts in.Harvard University finds that in 1994 a people absorbs 6 milligrams of lutein every day and can lower the incidence that senile macula lutea portion degenerates and reach 57% degree.(Seddon 1994)
Its molecular formula is C
40H
56O
2, and structural formula is:
This lutein is to the improvement of (Age-related Macular Degeneration is called for short AMD) pathology have a significant effect (Landrum J, T.et al.volume65,1997pp57～62 (6)) of degenerating of aging macula retinae district.
If this disease is not prevented may cause eye-blurred with treatment, bending can appear when seeing straight line, and severe patient vision central authorities can form blind spot gradually.
Ultraviolet ray generally can be filtered out by cornea and crystalline lens, but through retina of the penetrable eyeball of blue light and macula lutea produce a large amount of free radicals, cause cataract, macular area degeneration, and lutein can filter out blue light, avoids the infringement of blue light to eyes.Except the macula retinae district, lutein also is present in other tissue (crystalline, iris and ciliary body) of eyes, plays the part of an important role on the health of safeguarding eyes.
Lutein is a good antioxidant, can in and free radical, prevent cell by free radical damage, protection systemic cell health.Lutein in serum the inside can reduce thicken (Andrew Shao, the The Effect of Lutein on the progression of Atherosclerosis) of vascular wall.
This Lutein is a kind of natural carotenoid that exists in the natural vegetables and fruits originally again, and human body can not oneself synthesize, must be by just obtaining in the food.
2, lycopene (Lycopene), it is a unsaturated lipoid oil-soluble straight chain hydrocarbon compound, the most stable at occurring in nature, chemical formula is trans, but can form cis because of external factor such as illumination, heat energy, acid, oxygen or other chemical reagent impel lycopene to carry out isomerization.All belong to alltrans by the isolated lycopene major part of plant, but then trans and cis respectively accounts for 50% (Schierle 1996) in human plasma, show that the cis lycopene is more easily absorbed by human body.Tomato goods comparatively fresh tomato through processing has higher physiological activities (Shi 2000).Its molecular formula C
40H
56Structural formula is as follows:
Find that in many epidemiological studies the lycopene content that increases the picked-up of tomato goods and promote blood is inversely proportional to the probability of suffering from cancer, this shows that lycopene may have anticancer activity.Giovannucci E. found in 72 research cases in 1999, there are 57 to show the picked-up that increases the tomato goods and promote the blood lycopene, can reduce the probability of suffering from cancer, and the inverse relation that wherein has 35 is that significant difference is arranged, particularly the case effect to prostate, lung and stomach (Graham S 1990) etc. is the most obvious, and also shows preventive effect to a certain degree for pancreas, small intestine, rectum, esophagus, oral cavity (FreudenheimJL 1990), cervix (VanEenwyk J1991) and breast cancer (Freudenheim JL 1996).
Lycopene can prevent prostate cancer (Grant 1999), also can prevent the report of heart disease (Street 1994).
According to Total multicenter, the laboratory report of multinational EURAMIC, relatively the body fat tissue has the experimenter of higher lycopene concentration and the experimenter of the low lycopene concentration of body fat tissue content, and its probability of suffering from allegiant muscle infarction or cardiac asthenia reduces by 48% (Kohlmeier 1997) approximately.
3, (β-carotene) is a kind of powerful oil-soluble inhibitor that has to Beta-carrotene.Beta-carrotene has the chance (Klipstein-Grobusch K, 1999) that can reduce the elderly and suffer from heart disease 45%, helps to protect lung functions (Guenegou A 2006).
Beta-carrotene is known can be prevented that the low-density lipoprotein LDL in the artery (bad cholesterol) is oxidized and the vascular diseases of embolic takes place, and this is the common effect that many antioxidants have, and promptly has preventive effect for angiocardiopathy.
The molecular formula of Beta-carrotene is C
40H
56, and its structural formula is
4, β-carotene, Lutein and Lycopene still have the artery sclerosis of preventing function except that above-mentioned functions.
Tissue factor (tissue factor) is present in tissue, blood platelet and the white blood cell, is a plasma proteins that activates blood clotting.In case blood vessel is injured, tissue factor can increase, and blood is solidified easily.The increase of free radical in vascular wall can make tissue factor increase.People (2006) such as Dong Kun Lee deliver, and the generation of tissue factor increases, and connect with the cardiovascular disease association of development, owing to the increase of free radical in the vascular wall, influence the activity of endothelial cell, cause blood vessel embolism (thrombosisof blood vessels).The research and experiment of all carotenoid is found β-carotene, and Lutein and Lycopene add microemulsion respectively, makes it become the many activity (P＜0.01) that can suppress tissue factor (tissuefactor) in water-soluble back.
Fig. 1,2,3 is depicted as the effectiveness of the internal celliferous TFA of carotenoid of variable concentrations; Among the figure:
The control group is the microemulsion that does not have carotenoid.
Carotenoid is with β-carotene (Beta-carrotene), and each 0.5,2 and 10 μ mol/L of Lutein (lutein) and Lycopene (lycopene) test.
Learn the activity that these three kinds of carotenoid all can be suppressed tissue factor by accompanying drawing, prove the generation of energy prevention of arterial sclerosis.
5, vitamin C (Vitamin C) can be protected cell, strengthen leukocytic activity for belonging to water miscible antioxidant as everyone knows; Vitamin C and reinforced immunological ability, firm tissue, it is relevant that benefit is caught free radical, and can stop nitrite and amine to be combined into the inferior ammonium nitrate carcinogenic substance, so vitamin C also is one of anticancer nutrient.Vitamin C is to have the key player that health is repaired, if organize when injured, and the C that is deficient in vitamin, then wound healing is slow.Vitamin C can effectively be removed pressure and produce active oxygen, and can be consumed in a large number under its pressure, should many replenishing vitamins C.Its molecular formula: C
6H
8O
6, structural formula is:
Summary of the invention
The object of the present invention is to provide a kind ofly in certain diet capacity of human body required picked-up every day, add doses and belong to oil-soluble carrotene β-carotene, Lycopene, Lutein and water-soluble vitamin c antioxidant made drink or food.
Another object of the present invention is to provide a kind of can bring into play anti-ageing, anticancer, anti-disease, protection cell to human body, strengthen eyesight etc. spends drink or the food that obtains greatest benefit and best achievement.
For achieving the above object, the mixed weight that contains in the anti-oxidant compound that three kinds in the beta carotene that belongs to oil-soluble carotenoid, lycopene and lutein mixes with 0.5: 4: 4 weight ratio more provided by the invention is made powder or ingot shape as anti-oxidant drink or food than 10 vitamin C.
Described anti-oxidant drink or the food of containing, its every gram free radical scavenging activity ability of mixing antioxidant is greater than 5.48 * 10
4Ppm vitamin E clearance rate.
Described anti-oxidant drink or the food of containing, antioxidant vitamin C in its diet product accounts for 8.0mg～15.0mg that human body should absorb the diet consumption every day at least, beta carotene is 0.3mg～0.8mg, and lycopene is 2.0mg～8.0mg, and lutein is 2.0mg～8.0mg.
Described anti-oxidant drink or the food of containing, its antioxidant beta carotene, lycopene and lutein, being selected from wholefood becomes water-soluble or the oil-soluble powder with extracting process processing drying, is made into powder or lozenge then.
Described anti-oxidant drink or the food of containing, drink wherein is for dissolving in 120cc to 180cc non-metallic ion water, and makes in adding between 15 ℃～25 ℃ of the room temperatures.
Oozing of these four kinds of antioxidant provided by the invention mixes and can complementally will drop to minimum from normal cell effect and the oxidative damage that extraneous source is produced; Lutein, lycopene, this three kinds of oil-soluble carotenoid mix supplement agent of β-carotene, be proved the fracture that can reduce lymphocyte DNA interior bonds key, and the infringement of reduction DNA (Pool-Zobel et al, Carcinogenesis 1997; Cancer Epidemiol Biomarkers Prev 1998).The present invention adds behind the water-soluble vitamin c more proof and has strengthened its antioxidant effect, these four antioxidants, the really complementary mutually polyphenoils effect of strengthening for other of tool.
Though the antioxidant of other kind is also arranged, too much kind or excessive antioxidant, studying for a long period of time and test discovery and can cause on absorption of human body and the interfering with each other of biochemical effect through the inventor.
Old man and be in the industrial society of existing complexity and the adult under the working environment pressure (this is the situation that most of adults run into every day) and those are exposed to the organism of UV-radiation, cytotoxic chemical thing, infection or other strong injured dose, more oxidative damage (because variation that inner activity and outside agent bring) is also arranged probably, so the additional reinforcement human body antioxygen of multiple antioxidant is believed can more can help health to go prevent disease and prevent oxidation that pressure causes and damaged cell.
After mixing multiple carrotene, in oxidative damage, find that it is good (Johnson1997) that its absorptivity is absorbed lycopene more separately when lycopene and Beta-carrotene absorb jointly to anti-cell.
Above-mentioned four kinds of antioxidant are with the dosage number and the ratio of the present patent application claim, and finding really through test be lowest dose level and proper proportion, and can the most effective protection health, and reduce the quantity that DNA damages.Antioxidant in each scope of the invention increases by 1.5 times of quantity to twice, and its effect is still quite good.
Be used for antioxidant materials of the present invention, be selected from precision chemical is synthetic or wholefood is made with extracting process Vitamin C, β-carotene, Lycopene and Lutein, and become water-soluble or the oil-soluble powder through the specially treated drying, be made into powder dose fused (or little interface activating agent that adds) then or become lozenge and use.
Generation barbiturates reactive material as referred to herein (TBARS, thiobarbituric acid-reactivesubstances) is to survey the degree of lipid peroxidation (Lipid Peroxidation) and the index of lipid oxidation pressure (oxidative stress).Principle is can produce MDA (malondialdehyde in lipid oxidation process (lipid is attacked by free radical), be called for short MDA), the number of this MDA and for after barbiturates (thiobarbituric acid) reaction can form the red fluorescence reactant of the different depths.Remove to measure the light absorption value of this reactant with wavelength 532nm with spectrophotometer.This light absorption value height of healing is promptly represented MDA amount the more, therefore if sample (as Beta-carrotene of the present invention ... etc.) in course of reaction, remove polyradical more, the MDA amount that expression produces is more little, and light absorption value can be low more, represents that promptly free radical is had antiopxidant effect.In other words, light absorption value is lower, and the MDA amount is more little, shows that TBARS concentration is low more, represents antioxidant effect just better.
The assay method of TBARS is at present by a kind of pointer of scholar's application as radical pair human diseases or tissue injury.Oxidation resistance is strong more, and is low more for barbiturates reactive material (TBARS) concentration.
People such as Stahl measured with the TBARS method in 1998: the carotenoid of unitary class carrotene and mixing, it is separately for the oxidation resistance of free radical.Its measurement result such as following table:
| Unitary class carrotene | ||
| Sample | The TBARS that measures (%) | N |
| Control group (Control) | 100±9 | 35 |
| Lycopene (Lycopene) | 25±10 | 17 |
| Beta carrotene (β-carotene) | 73±9 | 30 |
| Lutein (Lutein) | 77±9 | 14 |
M (Molarity): the molar concentration/N of solute: the experiment homogenate tissue of mouse
Control: no polyphenoils
| The carotenoid that mixes | ||
| Sample | The TBARS that measures (%) | N |
| Lycopene adds Beta carrotene (Lycopene plus-β carotene) | 31±10 | 5 |
| Lycopene adds lutein (Lycopene plus Lutein) | 16±8 | 4 |
| Lutein adds Beta carrotene Lutein plus β-carotene | 44±8 | 9 |
M (Molarity): the molar concentration/N of solute: the experiment homogenate tissue of mouse
Control: no polyphenoils
From above two tables, find that the antioxygenic activity of lycopene is the highest, be Beta-carrotene and lutein successively.The carotenoid that mixes is than the more effective pre-anti-oxidation injury of single carotenoid.The most significant is that lycopene adds lutein, can significantly increase its antioxidant effect after both mixing.
It is the method for utilization with the ability of removing DPPH free radical that antioxidation activity of the present invention is measured.Because DPPH (1,1-Diphenyl-2-picrylhydrazyl) be very stable free radical, how present purple under the rice at wavelength 517, utilize various antioxidants its free radical electronics can be removed, and show that it removes the ability of free radical.
According to the present invention, get the Beta-carrotene that Sino-U.S.'s associating industry (upright great biochemical technology) produces, lycopene and lutein and the product that mixes (with preferable weight ratio 0.5: 4: 4) with these three kinds refer to food industry research institute (No. 331, Xinzhu City food road) do the test of oxidation resistance (removing DPPH free radical ability) must be as following table:
| Title | Clearance rate/gram (please join annex consignment test report) | The |
|
| 1. | B-carotene | Suitable 7.08 * 10 3Ppm VitE clearance rate | 095SA02236 |
| 2. | Lycopene | Suitable 2.35 * 10 4Ppm VitE clearance rate | 095SA02233 |
| 3. | Lutein | Suitable 7.69 * 10 2Ppm VitE clearance rate | 095SA02235 |
| 4. | 1,2 and 3 mixtures | Suitable 5.48 * 10 4Ppm VitE clearance rate | 095SA02349 |
Can find out clearly that by last table the free radical scavenging activity of mixture of the present invention is suitable 5.48 * 10
4Ppm VitE clearance rate is than its this single arithmetic sum 3.13 * 10 respectively
4Ppm VitE clearance rate is twice approximately, be 2.3 times of Lycopene, be 7.8 times of β-carotene, be 71.35 times of Lutein, and its antioxidation activity degree is that mixture＞Lycopene＞β-carotene＞" both can significantly increase its antioxidant effect after mixing to Lutein foot money proof mixture of the present invention with leading portion Stahl." argumentation match really and more to produce the effect that multiplies each other, its antioxidation activity is again greater than its this single antioxidant effect respectively.
Description of drawings
Fig. 1,2,3 is depicted as the effectiveness of the internal celliferous TFA of carotenoid of variable concentrations.
Fig. 4 is the extent of damage schematic diagram of edible different victual rear perimeter edge blood-lymphatic system DNA.
The specific embodiment
For making the present invention more clear, below the present invention is described with embodiment:
With the experimenter is the healthy and male sex that do not smoke between 23 27-40 year.In fortnight, edible normal diet but avoid containing the vegetables of the high carotenoids of unit.The 3rd and the four stars phase, they drink the 330cc tomato fruit juice that includes the 40mg lycopene every day.In the 5th and the 6th week, they eat the 330ml carrot juice that includes 22.3mg β-carotene and 15.7mg alpha-carotene.The 7th and eight weeks, the edible 10g water of 11.3mg Lutein or the dried spinach powder that milk brews of including.
In research process, jede Woche is collected blood, and detects the condition in damaged of peripheral blood-lymphatic system DNA with ' Comet assay '.Learn from the result, replenish tomato, carrot and spinach product, can reduce the fracture of lymphocyte DNA interior bonds key significantly.(Pool-Zobel et al，Carcinogenesis 1997)。Its curve map is consulted Fig. 4.
With 37 health, do not have to smoke, the women of back between 50 years old to 70 years old climacteric be assigned to five groups with random number way.All give the different dosage that mix respectively these five groups of every day.First group: Beta-carrotene, Lycopene, Lutein (each part is 4mg) are the 12mg that has only single component for other three groups, second group is Lutein 12mg, the 3rd group is Beta-carrotene 12mg, and the 4th group is Lycopene 12mg, and the 5th group is control group.
Behind edible carrotene the 57th day, each group was compared with first day, and the injury rate of certain degree reduction DNA is all arranged.But in the time of the 15 day, mix three kinds of dosage: first group of Beta-carrotene, Lycopene, Lutein promptly has significant difference.(Xianfeng Zhao et al，Am J ClinNutr 2006)
With 20 healthy womens of 25.2 years old mean age, first week was given earlier the diet of standard, three weeks afterwards, added the Beta-carrotene of Lycopene, 0.5mg of average 8mg and the Vitamin C of 11mg every day.Analysis classes carrotene, vitamin C and the vitamin E storage in blood and lymph.Use " Comet assay " and HPLC analyze the protection that detects lymphocytic DNA.
The result: can increase Lycopene in blood plasma and lymphocytic concentration, in blood plasma, ascorbic concentration increases by～35% (P＜0.05), in lymphocyte～230% (P＜0.005).Vitamin E reduces in blood plasma on the contrary significantly, but not in lymph gland.Vitamin E is not the oxidative damage that can protect DNA clearly.
Conclusion: Beta-carrotene, Lycopene can increase ascorbic biochemical availability.This effect is the result who increases from different antioxidants.This is to select Vitamin C why and without the reason of vitamin e.(P Riso European Journal of Clinical Nutrition 2004)
Being divided into 5 people with 15 the elderly about 50 years old mean age is one group the first and second the third three groups, will be should take the photograph the powder that diet uses at least every day or to make the vitamin C of ingot shape and be equivalent to vitamin E 5.48 * 10
4The Beta-carrotene of ppm clearance rate, lycopene and lutein mixing antioxidant such as following table dosage are divided into three groups of allotments and supply its diet:
| Antioxidant/ |
1 | 2 | 3 |
| Vitamin C | 8.0mg | 10.0mg | 15.0mg |
| Beta-carrotene | 0.3mg | 0.5mg | 0.8mg |
| Lycopene | 2.0mg | 4.0mg | 8.0mg |
| Lutein | 2.0mg | 4.0mg | 8.0mg |
First week gave diet according to first, second, third order respectively according to 1,2,3 dosage of tabular, and second week is just with second, third, first and the order of the 3rd week third, first, second.Though the tested personnel of inquiry find that its test period is three very short weeks after the diet, the consumption of the antioxidant of first group is past high by low concentration, third group past low by high concentration on the contrary, and the second group be by in toward high return low, but these tested personnel of three groups have a common ground, mood is better sensuously taking the back when not taking then to refer to meaning, the vigor increase.
Claims (5)
1. one kind contains in the anti-oxidant compound that three kinds in the beta carotene that belongs to oil-soluble carotenoid, lycopene and lutein mixes with 0.5: 4: 4 weight ratio mixed weight again and is made powder or ingot shape as anti-oxidant drink or food than 10 vitamin C.
2. according to containing of claim 1 anti-oxidant drink or food, its every gram free radical scavenging activity ability of mixing antioxidant is greater than 5.48 * 10
4Ppm vitamin E clearance rate.
3. according to containing of claim 1 anti-oxidant drink or food, antioxidant vitamin C in its diet product accounts for 8.0mg～15.0mg that human body should absorb the diet consumption every day at least, beta carotene is 0.3mg～0.8mg, lycopene is 2.0mg～8.0mg, and lutein is 2.0mg～8.0mg.
4. according to containing of claim 1 anti-oxidant drink or food, its antioxidant beta carotene, lycopene and lutein are selected from wholefood and handle drying with extracting process and become water-soluble or the oil-soluble powder, are made into powder or lozenge then.
5. each contains anti-oxidant drink or food according to claim 1 to 3, and drink wherein is for dissolving in 120cc to 180cc non-metallic ion water, and makes in adding between 15 ℃～25 ℃ of the room temperatures.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114712476A (en) * | 2017-04-03 | 2022-07-08 | 大江生医股份有限公司 | Composition containing plant extract and application of composition to promoting testosterone secretion |
-
2006
- 2006-08-09 CN CNA2006101121051A patent/CN101120792A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114712476A (en) * | 2017-04-03 | 2022-07-08 | 大江生医股份有限公司 | Composition containing plant extract and application of composition to promoting testosterone secretion |
| US11806317B2 (en) | 2017-04-03 | 2023-11-07 | Tci Co., Ltd. | Composition capable of promoting testosterone secretion and use thereof |
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