CN101073640B - Externally-applied medicine for treating moist wart - Google Patents
Externally-applied medicine for treating moist wart Download PDFInfo
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- CN101073640B CN101073640B CN200610010902A CN200610010902A CN101073640B CN 101073640 B CN101073640 B CN 101073640B CN 200610010902 A CN200610010902 A CN 200610010902A CN 200610010902 A CN200610010902 A CN 200610010902A CN 101073640 B CN101073640 B CN 101073640B
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- condyloma acuminatum
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Abstract
The invention is concerned with the externally applied agent can use for condyloma acuminatum, and it contents: fructus bruceae 200-600, radix sophorae flavescentis 100- 500, Himalayan mayapple 100-400, giant knotweed 10-100, china root 1-50, Shikonin 1-50, oleum eucalypti 100-500m, lavender spike oil 50-250, Twain-80 10-100, propanediol 50-200 as the raw materials. The invention is with proved curative effect diminishing inflammation and easing pain. It is with over 92% of curing rate, 96% of total curative effect rate and relapse rate below 10%.
Description
Technical field: a kind of external used medicine that is used for the treatment of condyloma acuminatum, relating to a kind of is the externally-applied medicine composite that raw material is made with the vegetable Chinese herbal medicine.
Background technology: annual morbidity increases surplus good the sending out in the soft vegetation of mucocutaneous intersection that condyloma acuminatum is caused by human nipple virus, condyloma acuminatum nearly ten, does not still have specific drug at present.Main both at home and abroad at present Western medicine such as the 5-fluorouracil of using, phthalein tincture amine cream, colchicine, formaldehyde, carbolic acid, new JIEERYIN, podophyllum, Wartec, wart takes off the glad treatment of Denging; Except that pharmacotherapy, released therapies such as freezing, laser, electrosurgery and excision again, these therapies are each has something to recommend him.But the Chinese medicine preparation of treatment condyloma acuminatum is not seen listing.
Summary of the invention: purpose of the present invention aims to provide a kind ofly has remarkable therapeutical effect, Chinese medicine safe in utilization to condyloma acuminatum.
Pharmaceutical composition of the present invention is the exterior-applied formulation of being made by the following weight proportion raw material: Fructus Bruceae 200～600, Radix Sophorae Flavescentis 100～500, Chinese podophyllum root 100～400, Rhizoma Polygoni Cuspidati 10～100, Rhizoma Smilacis Glabrae 1～50, Radix Arnebiae (Radix Lithospermi) 1～50, Oleum Eucalypti 100～500m, Peppermint Oil 50～250, tween
-8010～100, propylene glycol 50～200.
Pharmaceutical composition of the present invention is the exterior-applied formulation of being made by the following weight proportion raw material: Fructus Bruceae is that 400g, Radix Sophorae Flavescentis are that 300g, Chinese podophyllum root are that 200g, Rhizoma Polygoni Cuspidati are that 50g, Rhizoma Smilacis Glabrae are that 20g, Radix Arnebiae (Radix Lithospermi) are that 20g, Oleum Eucalypti are that 250g, Oleum menthae are 100g, tween
-80For 50g and propylene glycol are 100ml.
The present invention has no side effect through the toxicity test proof; Have effects such as significant antiinflammatory, analgesia through pharmacodynamic study; Through clinical trial, the cure rate for the treatment of condyloma acuminatum is reached more than 92%, total effective rate reaches more than 96%, and relapse rate is lower than 10%.
Pharmacodynamic study
Pharmacodynamics test shows, the present invention all has in various degree antibacterial action to staphylococcus aureus, escherichia coli, bacillus pyocyaneus, beta hemolytic streptococcus, Candida albicans in vitro tests; Staphylococcus albus and gonococcus there is not antibiotic effect.Putting administration outward on the skin does not have obvious inhibitory action to the closure furuncle and phyma that subcutaneous connective tissue injects staphylococcus aureus formation, but can make the focus limitation, and diffusion is infected in restriction, and minimizing is oozed out, and helps the treatment of furuncle and phyma.Skin of the present invention is put administration outward on the skin and is shown tangible antiinflammatory action, and the permeability that can significantly suppress dimethylbenzene induced mice capillary of skin increases; Can significantly suppress dimethylbenzene induced mice auricle edema; Can significantly suppress stimulates caused leukoplania by the rat carboxymethyl cellulose; Subcutaneous rat agar granulation hyperplasia there is remarkable inhibitory action; Granulation due to the rat cotton balls is formed with significant inhibitory effect.Use medicine outward, the mouse peritoneal injection writhing response that acetic acid produced is had significant inhibitory effect.
1, vitro antibacterial activity is observed
Adopt the test tube doubling dilution.Get during experiment 8.9ml is housed respectively, sulfur-bearing ethanol culture medium, some in the test tube of GC medium or mould medium, every pipe add the present invention or each 1ml of JIEERYIN medicinal liquid and the dilution bacterium liquid 0.1ml that is diluted to a series of concentration by double dilution method respectively.It is 10 that the final concentration of bacterium liquid removes beta hemolytic streptococcus
2Outside the CFU/ml, all the other bacterial strains are 10
4CFU/ml. putting 37 ℃ cultivated 18 hours, the drug level of no bacterial growth pipe is minimal inhibitory concentration (MIC). the results are shown in Table 1 and table 2. as seen from Table 1, the present invention's (clinical concentration of using) is to staphylococcus aureus, escherichia coli, bacillus pyocyaneus, beta hemolytic streptococcus MIC is 0.05ml (medicinal liquid)/ml, Candida albicans is 0.025ml (medicinal liquid)/ml, to Staphylococcus albus and gonococcus unrestraint effect. as seen from Table 2, contrast medicine JIEERYIN is 0.0125ml (medicinal liquid)/ml to beta hemolytic streptococcus MIC, to staphylococcus aureus and Candida albicans is 0.025ml (medicinal liquid)/ml, is 0.05ml (medicinal liquid)/ml to escherichia coli and bacillus pyocyaneus; Staphylococcus albus and gonococcus there are not bacteriostasis.
Table 1 bacteriostatic test result of the present invention (liquid tube method)
Table 2 JIEERYIN XIYE bacteriostatic test result (liquid tube method)
2, the influence of xylol induced mice capillary of skin permeability increase
80 of mices, the ICR strain, body weight 18-22g, male and female half and half, provide (one-level animal by Company Development Department of Yunan Baiyao Industry Co., Ltd. institute, quality certification book number: NO.0001760). with electric hair cutter its back and the positive middle part of abdomen hair are cut off, divide equally four groups, every group 20, male and female half and half. during experiment, each is organized mouse back and is coated with respectively and puts solvent on the skin, the present invention's (height, the low concentration diluent), the indomethacin diluent, each 0.2ml/ only, behind the coating 2 hours, with distilled water flush away medicinal liquid, and put on the skin only with dry cotton ball, every day secondary, continuous use three days. apply ointment back one hour to the blue normal saline 0.1ml/10g of mouse tail vein injection 0.5% ivens in last, melted paraxylene 0.05ml/ is only on the skin of unhairing of mouse web portion center immediately, take off cervical vertebra after 20 minutes and put to death, peel skin of abdomen, be affixed on after the upset on the white enamel tray, according to the locus coeruleus color and luster depth it is divided into six grades, a rank is remembered one fen, and after the scoring, every skin locus coeruleus is shredded input with operating scissors to be had in the plug teat glass, pour acetone-sodium sulfate extracting solution 10ml into, put the dark place and place, shake test tube 2-3 time every day gently, after 3 days, centrifugal 10 minutes of 2000rpm, get supernatant in 590nm place colorimetric determination optical density, (doing blank pipe school zero with the acetone-sodium sulfate extracting solution of end bubble tissue) calculates the locus coeruleus amount of dye again. the results are shown in Table 3.
The influence that table 3 xylol induced mice of the present invention skin capillary permeability increases (x ± sD)
Annotate: compare * * with matched group; P＜0.01
Conclusion: liniment of the present invention can significantly suppress mice caused by dimethylbenzene xylene skin capillary percolation increase effect.
3, to the influence of leukoplania in the rat carboxymethyl cellulose capsule
40 of rats, the SD strain, 200-250g, male and female are provided by Yunan Baiyao Industry Co., Ltd.'s development division institute, (the one-level animal, quality certification book number: NO.001761), divide equally four groups, 10 every group, male and female half and half.Cut off back and belly wool with electric hair cutter.Each is organized rat and is coated with respectively and puts solvent, indomethacin diluent, the present invention's (high and low concentration dilution liquid) on the skin, and each consumption 1ml/200g put wash clean on the skin with distilled water after two hours, and secondary connected and was coated with three days every day.In second day of coating, under the sterile working, inject air 5ml to the back, make the formation round balloon, inferior daily sterile syringe injects 1.5% each 0.1ml of sodium carboxymethyl cellulose normal saline in capsule, inject the test tube that fills 0.05% brilliant cresyl blue normal saline (PH7.2) 3ml respectively, mixing dyeing is dripped after 2 minutes on the numeration of leukocyte plate, counts leukocyte count down in light microscopic, converses the total white blood cells of every ml CF again.The results are shown in Table 4.
Table 4 the present invention is to the influence of leukoplania in the rat carboxymethyl cellulose capsule (x ± sD)
Annotate: compare with matched group: P＜0.05, * *: P＜0.01
Conclusion: the present invention can significantly suppress rat stimulates the migration in fibrous capsule of caused leukocyte by carboxymethyl cellulose.
4, to the influence of mice auricle swelling
60 of mices, the Kunming kind, body weight 25-28g, male, provide quality certification book number by the institute for drug control, Yunnan Province: No. the 001st, the moving pipe of cloud word; Be divided into 6 groups at random, every group 10. be coated with dimethylbenzene and put two sides before and after the ear of a mice left side on the skin, every 0.02ml causes inflammation, matched group is only put solvent 0.1ml/ on the skin after half an hour, the hydrocortisone group is only put 0.1ml/ on the skin, JIEERYIN high and low dose group is put 0.2ml/ and 0.1ml/ respectively on the skin, of the present invention group of medicinal liquid 0.1ml/ of putting high and low concentration respectively on the skin. every 4 hours, mice is taken off cervical vertebra puts to death, card punch with the 9mm diameter is got auricle in same area respectively, weigh in torsion balance, it is the swelling degree that every Mus left side auricle weight deducts auris dextra sheet weight, the results are shown in Table 5.
The influence of table 5 xylol Mice Auricle of the present invention inflammation (n=10 x ± sD)
Annotate: medicine group and matched group compare, t check or correction t check
Conclusion: experimental result shows that the high and low concentration of the present invention swells to the Mice Auricle caused by dimethylbenzene xylene tangible detumescence effect, compares with the solvent control group, and through the t check, difference has utmost point significance meaning (P＜0.001)).
5, to the influence of agar granulation tissue hyperplasia
50 of SD rats, body weight 180-200g, male, by the supply of pharmacology key lab of unming Medical College, quality certification book number: No. the 011st, the moving pipe of cloud word, be divided into 4 groups at random, 10 every group, experiment is preceding with the back unhairing, sterilization, subcutaneous injection 2% agar solution 2ml.Cause the scorching same day, matched group is only put solvent 1ml/ on the skin, and the indomethacin group is only put indomethacin diluent 1ml/ on the skin, and high and low dose group of the present invention is put diluent 1ml/ of the present invention of high and low concentration respectively on the skin, applies ointment continuous use 15 days every day 1 time.Cause scorching back 15 days, take off vertebra and put to death animal, anatomical isolation goes out the granulation agar block, and the weighing weight in wet base the results are shown in Table 6.
Table 6 the present invention is to the granulomatous influence of rat agar (n=10 x ± sD)
Annotate: medicine group and matched group compare, the t check.
Conclusion: the present invention has obvious inhibitory action to rat agar local subcutaneous granulation group hypertrophy, compares with matched group, and difference has the property meaning (P＜0.01) of highly significant.
6, to the influence of rat granuloma hamartoplasia
40 of SD rats, body weight 150-200g, male, provide by Yunan Baiyao Industry Co., Ltd.'s institute, quality certification book number: NO.001761 is under the ether light anaesthesia, respectively at the subcutaneous sterilization cotton balls 20mg that respectively inserts of the bilateral pars inguinalis after strict sterilization.The postoperative animal is divided equally 4 groups, 10 every group.After each organizes the rat abdomen unhairing, be coated with respectively and put solvent, indomethacin diluent, the present invention's (high and low concentration dilution liquid) on the skin, each 1ml/200g was coated with and puts 2 times on the skin, after applying ointment two hours, with distilled water flush away medicinal liquid at every turn on the 1st.Continuous six days, put to death animal in the 7th day.Carefully peel off cotton balls granulation tissue thymus and adrenal gland after weighing, the cotton balls granulation tissue put 90 ℃ of oven dry in the baking oven, weigh after 1 hour, with claim weight deduct the raw cotton ball weight and be the granuloma net weight, the results are shown in Table 7.
Table 7 the present invention causes the influence that the rat granulation forms (x ± sD) to the sterilization cotton balls
Annotate: compare * * with matched group: P＜0.01
Conclusion: as seen from Table 7, the present invention is formed with remarkable inhibitory action (P＜0.01) to granulation due to the cotton balls, but thymus and adrenal weight are not seen obvious influence.
7, the present invention causes the effect of local subcutaneous closure furuncle and phyma to golden Portugal bacterium
50 of SD rats, body weight 180-200g, male and female half and half are supplied with by Yunan Baiyao Industry Co., Ltd.'s development division institute, and quality certification book number NO.001761 is divided into 5 groups at random, 10 every group.After the abdominal part unhairing, (bacterial content is 1.5 * 10 to inject golden yellow staphylococcus normal saline diluent 1ml between two omoplates in the subcutaneous connective tissue
5CFU/ml), cause the local subcutaneous closure to infect.Annotate bacterium after 12 hours, each is organized rat abdomen and is coated with respectively and puts solvent, indomethacin diluent, the present invention's (high and low concentration dilution liquid), every Mus 1ml, coating secondary on the one on the skin.The reuse dry cotton ball was cleaned with distilled water flush away medicinal liquid in 2 hours behind each coating.Other establishes a positive drug control group, the intramuscular injection gentamycin sulfate, and every Mus 0.1ml (pastille 4,000 units), injection on the one is once.All rat continuous uses 7 days were put to death animal on the 8th day, observed the furuncle and phyma situation, the results are shown in Table 8.
Table 8: the present invention causes the influence (x ± s Dg) of subcutaneous closure furuncle and phyma to golden Portugal bacterium
Annotate: compare with matched group, △: P＜0.05, △ △: P＜0.01 are compared with the gentamycin group in * *: P＜0.01.
Above result shows, skin of the present invention is coated with puts administration on the skin, the suppression ratio that subcutaneous closure furuncle and phyma due to the golden Portugal bacterium is formed is 22.5-27.5%, compare with the solvent control group, difference nonsignificance (P＞0.05), but can make focus limitation, the diffusion that restriction is infected, reduce inflammatory exudation, help the treatment of furuncle and phyma.
8, the influence that mouse writhing is reacted
60 of Kunming mouses, body weight 18-22g, male and female half and half are provided by the institute for drug control, Yunnan Province, quality certification book number: No. the 001st, the moving pipe of cloud word; Be divided into 6 groups at random, 10 every group, test preceding 24 hours the mouse web portion unhairing.Matched group is only put solvent 0.2ml/ on the skin in the unhairing abdominal part during experiment, the indomethacin group is only put indomethacin liniment 0.2ml/ on the skin, JIEERYIN high and low dose group is only put JIEERYIN XIYE 0.4 and 0.2ml/ respectively on the skin, and high and low dose group of the present invention is only put each 0.2ml/ of high and low concentration the present invention respectively on the skin; The one-time continuous of applying ointment every one hour 3 times, in applying ointment back 30 minutes for the last time, lumbar injection 0.6% acetic acid solution (with the normal saline preparation) 0.2ml/ only turns round the body total degree after 5 minutes in the record 20 minutes, the results are shown in Table 9.
Table 9: the influence of turning round the body number of times that the present invention causes mice acetic acid (n=10 x ± sD)
Annotate: medicine group and matched group compare, the t check
Conclusion: the present invention has the obvious suppression effect to the writhing response that mouse peritoneal injection acetic acid causes.The suppression ratio of high and low concentration is respectively 75% and 59.9%, and with the increase of dosage, inhibitory action strengthens.
Conclusion:
In-vitro antibacterial test shows, the present invention all has in various degree inhibitory action to staphylococcus aureus, escherichia coli, bacillus pyocyaneus, beta hemolytic streptococcus, Candida albicans; Staphylococcus albus and gonococcus there is not bacteriostasis.The present invention puts administration outward on the skin does not have obvious inhibitory action to the closure furuncle and phyma that injects the bacterium formation of golden Portugal in the subcutaneous connective tissue, but can make the focus limitation, and diffusion is infected in restriction, minimizing is oozed out, and helps the treatment of furuncle and phyma.Skin of the present invention is used medicine outward, and percutaneous absorbs good, shows tangible antiinflammatory action, and can significantly suppress dimethylbenzene induced mice capillary of skin permeability increases; Can significantly suppress the rat carboxymethyl cellulose and stimulate caused leukoplania; Subcutaneous rat agar granulation there is remarkable inhibition proliferative effect; Granulation due to the rat cotton balls is formed with significant inhibitory effect.Above-mentioned antiinflammatory result of the test shows that skin of the present invention is used medicine outward, no matter all there is significant inhibitory effect in inflammation early stage (the saturating property of blood vessel and ooze out swelling), mid-term (leukocyte chemotaxis migration) and later stage (granulation tissue hyperplasia).In addition, using medicine outward has significant inhibitory effect to the mouse peritoneal injection writhing response that acetic acid produced, and shows the analgesic effect that tool of the present invention is certain.The above test of pesticide effectiveness shows that the present invention has functions such as detoxifcation, detumescence, pain relieving.
The specific embodiment: a kind of external used medicine that is used for the treatment of condyloma acuminatum, by weight ratio, Fructus Bruceae is that 400g, Radix Sophorae Flavescentis are that 300g, Chinese podophyllum root are that 200g, Rhizoma Polygoni Cuspidati are that 50g, Rhizoma Smilacis Glabrae are that 20g, Radix Arnebiae (Radix Lithospermi) are that 20g, Oleum Eucalypti are that 250g, Oleum menthae are 100g, tween
-80For 50g and propylene glycol are 100ml.
Embodiment 1: a kind of external used medicine that is used for the treatment of condyloma acuminatum, by weight ratio, Fructus Bruceae is that 400g, Radix Sophorae Flavescentis are that 300g, Chinese podophyllum root are that 200g, Rhizoma Polygoni Cuspidati are that 50g, Rhizoma Smilacis Glabrae are that 20g, Radix Arnebiae (Radix Lithospermi) are that 20g, Oleum Eucalypti are that 250g, Oleum menthae are 100g, tween
-80For 50g and propylene glycol are 100ml.Through extracting, add the existing routinely preparation technique of corresponding auxiliary material and make liniment.
Embodiment 2: according to the ratio of embodiment 1, through extracting, add the existing routinely preparation technique of corresponding auxiliary material and make aerosol.
Embodiment 3: according to the ratio of embodiment 1, through extracting, add the existing routinely preparation technique of corresponding auxiliary material and make liniment.
Claims (3)
1. external used medicine that is used for the treatment of condyloma acuminatum, it is characterized in that making Fructus Bruceae 200～600, Radix Sophorae Flavescentis 100～500, Chinese podophyllum root 100～400, Rhizoma Polygoni Cuspidati 10～100, Rhizoma Smilacis Glabrae 1～50, Radix Arnebiae (Radix Lithospermi) 1～50, Oleum Eucalypti 100～500, Peppermint Oil 50～250, tween by following materials of weight proportions
-8010～100 and propylene glycol 50～200.
2. an external used medicine that is used for the treatment of condyloma acuminatum is characterized in that by Fructus Bruceae being that 400g, Radix Sophorae Flavescentis are that 300g, Chinese podophyllum root are that 200g, Rhizoma Polygoni Cuspidati are that 50g, Rhizoma Smilacis Glabrae are that 20g, Radix Arnebiae (Radix Lithospermi) are that 20g, Oleum Eucalypti are that 250g, Oleum menthae are 100g, tween
-80For 50g and propylene glycol are that 100ml makes.
3. according to claim 1 and 2 described a kind of external used medicines that are used for the treatment of condyloma acuminatum, it is characterized in that making liniment, aerosol, liniment, rubber-emplastrum, cataplasma, doubt colloid.
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| CN200610010902A CN101073640B (en) | 2006-05-18 | 2006-05-18 | Externally-applied medicine for treating moist wart |
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|---|---|---|---|
| CN200610010902A CN101073640B (en) | 2006-05-18 | 2006-05-18 | Externally-applied medicine for treating moist wart |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103055213B (en) * | 2013-01-20 | 2015-08-26 | 上海浦东高星生物技术研究所 | A kind of Chinese medicine decoction of wart of dispelling |
| CN110368463A (en) * | 2019-07-31 | 2019-10-25 | 北京派特博恩生物技术开发有限公司 | A kind of Chinese medicine composition and the preparation method and application thereof for treating human papilloma virus HPV infection |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1583038A (en) * | 2004-06-02 | 2005-02-23 | 严跃华 | Skin bactericidal medicine and its preparation |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1583038A (en) * | 2004-06-02 | 2005-02-23 | 严跃华 | Skin bactericidal medicine and its preparation |
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