CN101066244A - Small volume vincamine injection and its prepn process - Google Patents
Small volume vincamine injection and its prepn process Download PDFInfo
- Publication number
- CN101066244A CN101066244A CN 200610152514 CN200610152514A CN101066244A CN 101066244 A CN101066244 A CN 101066244A CN 200610152514 CN200610152514 CN 200610152514 CN 200610152514 A CN200610152514 A CN 200610152514A CN 101066244 A CN101066244 A CN 101066244A
- Authority
- CN
- China
- Prior art keywords
- vinpocetine
- antioxidant
- cosolvent
- physically stable
- stable agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000002347 injection Methods 0.000 title claims abstract description 22
- 239000007924 injection Substances 0.000 title claims abstract description 22
- RXPRRQLKFXBCSJ-GIVPXCGWSA-N vincamine Chemical compound C1=CC=C2C(CCN3CCC4)=C5[C@@H]3[C@]4(CC)C[C@](O)(C(=O)OC)N5C2=C1 RXPRRQLKFXBCSJ-GIVPXCGWSA-N 0.000 title abstract description 26
- RXPRRQLKFXBCSJ-UHFFFAOYSA-N dl-Vincamin Natural products C1=CC=C2C(CCN3CCC4)=C5C3C4(CC)CC(O)(C(=O)OC)N5C2=C1 RXPRRQLKFXBCSJ-UHFFFAOYSA-N 0.000 title abstract description 13
- 229960002726 vincamine Drugs 0.000 title abstract description 13
- 238000000034 method Methods 0.000 title description 4
- 239000006184 cosolvent Substances 0.000 claims abstract description 16
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 14
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 14
- 239000003814 drug Substances 0.000 claims abstract description 12
- 238000002360 preparation method Methods 0.000 claims abstract description 11
- 230000000638 stimulation Effects 0.000 claims abstract description 10
- DDNCQMVWWZOMLN-IRLDBZIGSA-N Vinpocetine Chemical compound C1=CC=C2C(CCN3CCC4)=C5[C@@H]3[C@]4(CC)C=C(C(=O)OCC)N5C2=C1 DDNCQMVWWZOMLN-IRLDBZIGSA-N 0.000 claims description 28
- 229960000744 vinpocetine Drugs 0.000 claims description 28
- 239000003795 chemical substances by application Substances 0.000 claims description 18
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 claims description 16
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 14
- 235000006708 antioxidants Nutrition 0.000 claims description 13
- 230000002792 vascular Effects 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 9
- 229940079593 drug Drugs 0.000 claims description 9
- 235000010265 sodium sulphite Nutrition 0.000 claims description 8
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 7
- 239000003610 charcoal Substances 0.000 claims description 7
- 229940105082 medicinal charcoal Drugs 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 7
- 239000008215 water for injection Substances 0.000 claims description 6
- 235000010323 ascorbic acid Nutrition 0.000 claims description 5
- 239000011668 ascorbic acid Substances 0.000 claims description 5
- 229960005070 ascorbic acid Drugs 0.000 claims description 5
- 239000000047 product Substances 0.000 claims description 5
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 claims description 5
- 235000010262 sodium metabisulphite Nutrition 0.000 claims description 5
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 4
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 4
- 229930195725 Mannitol Natural products 0.000 claims description 4
- 239000002671 adjuvant Substances 0.000 claims description 4
- 210000004204 blood vessel Anatomy 0.000 claims description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 4
- 239000000594 mannitol Substances 0.000 claims description 4
- 235000010355 mannitol Nutrition 0.000 claims description 4
- 239000000600 sorbitol Substances 0.000 claims description 4
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 claims description 4
- 238000010521 absorption reaction Methods 0.000 claims description 3
- 238000001816 cooling Methods 0.000 claims description 3
- 238000009472 formulation Methods 0.000 claims description 3
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 claims description 3
- 235000019345 sodium thiosulphate Nutrition 0.000 claims description 3
- KGRVJHAUYBGFFP-UHFFFAOYSA-N 2,2'-Methylenebis(4-methyl-6-tert-butylphenol) Chemical compound CC(C)(C)C1=CC(C)=CC(CC=2C(=C(C=C(C)C=2)C(C)(C)C)O)=C1O KGRVJHAUYBGFFP-UHFFFAOYSA-N 0.000 claims description 2
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 2
- 229920002307 Dextran Polymers 0.000 claims description 2
- 108010010803 Gelatin Proteins 0.000 claims description 2
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims description 2
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Natural products NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 2
- 229930003268 Vitamin C Natural products 0.000 claims description 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 2
- 235000018417 cysteine Nutrition 0.000 claims description 2
- 229920000159 gelatin Polymers 0.000 claims description 2
- 239000008273 gelatin Substances 0.000 claims description 2
- 235000019322 gelatine Nutrition 0.000 claims description 2
- 235000011852 gelatine desserts Nutrition 0.000 claims description 2
- 239000004310 lactic acid Substances 0.000 claims description 2
- 235000014655 lactic acid Nutrition 0.000 claims description 2
- 229930182817 methionine Natural products 0.000 claims description 2
- 235000019154 vitamin C Nutrition 0.000 claims description 2
- 239000011718 vitamin C Substances 0.000 claims description 2
- 238000005303 weighing Methods 0.000 claims description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 1
- 108010009736 Protein Hydrolysates Proteins 0.000 claims 1
- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 239000003381 stabilizer Substances 0.000 abstract 1
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 5
- 239000001632 sodium acetate Substances 0.000 description 5
- 235000017281 sodium acetate Nutrition 0.000 description 5
- 206010008190 Cerebrovascular accident Diseases 0.000 description 3
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 description 3
- 206010012289 Dementia Diseases 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 208000006011 Stroke Diseases 0.000 description 3
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 3
- 235000001014 amino acid Nutrition 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 230000002490 cerebral effect Effects 0.000 description 3
- 239000011975 tartaric acid Substances 0.000 description 3
- 235000002906 tartaric acid Nutrition 0.000 description 3
- 241000522254 Cassia Species 0.000 description 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 2
- 229940099471 Phosphodiesterase inhibitor Drugs 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 235000019445 benzyl alcohol Nutrition 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 230000000302 ischemic effect Effects 0.000 description 2
- 239000002571 phosphodiesterase inhibitor Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 244000037364 Cinnamomum aromaticum Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- HCBIBCJNVBAKAB-UHFFFAOYSA-N Procaine hydrochloride Chemical compound Cl.CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 HCBIBCJNVBAKAB-UHFFFAOYSA-N 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- 201000006559 Vertebrobasilar insufficiency Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 239000003708 ampul Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 201000010861 basilar artery insufficiency Diseases 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000005660 chlorination reaction Methods 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 235000015165 citric acid Nutrition 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000004153 glucose metabolism Effects 0.000 description 1
- 230000002008 hemorrhagic effect Effects 0.000 description 1
- 239000000413 hydrolysate Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- 239000008176 lyophilized powder Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 235000006109 methionine Nutrition 0.000 description 1
- 230000000324 neuroprotective effect Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 229960001309 procaine hydrochloride Drugs 0.000 description 1
- 239000002510 pyrogen Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | |
Principal agent | Vinpocetine 10g | Vinpocetine 10g | Vinpocetine 10g | Vinpocetine 10g |
Cosolvent | Acetic acid 1g | Ascorbic acid 1g | Ascorbic acid 1g | Ascorbic acid 1g |
Antioxidant | Sodium sulfite 2g | Sodium sulfite 2g | Sodium pyrosulfite 2g | Sodium pyrosulfite 2g |
The physically stable agent | Mannitol 100g | Sorbitol 100g | Mannitol 100g | Sorbitol 100g |
The regulation of blood vessels stimulant | Benzyl alcohol 20g | Cassia oil alcohol 20g | Cassia oil alcohol 20g | Benzyl alcohol 20g |
The pH value regulator | Sodium acetate is an amount of | Sodium acetate is an amount of | Sodium acetate is an amount of | Tartaric acid is an amount of |
Medicinal charcoal | In right amount | In right amount | In right amount | In right amount |
Water for injection | 2000ml | 2000ml | 2000ml | 2000ml |
Claims (7)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2006101525144A CN100522163C (en) | 2006-09-28 | 2006-09-28 | Small volume vincamine injection and its preparation process |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2006101525144A CN100522163C (en) | 2006-09-28 | 2006-09-28 | Small volume vincamine injection and its preparation process |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101066244A true CN101066244A (en) | 2007-11-07 |
CN100522163C CN100522163C (en) | 2009-08-05 |
Family
ID=38879025
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2006101525144A Active CN100522163C (en) | 2006-09-28 | 2006-09-28 | Small volume vincamine injection and its preparation process |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN100522163C (en) |
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101889978A (en) * | 2010-04-29 | 2010-11-24 | 袁璐 | Pharmaceutical composition containing vinpocetine, preparation method and application thereof |
CN101264064B (en) * | 2008-04-17 | 2011-04-20 | 孙向阳 | Vinpocetine freeze-dried powder for injection and preparation thereof |
CN102160853A (en) * | 2011-02-11 | 2011-08-24 | 方宝林 | Vinpocetine injection and preparation method thereof |
CN102228428A (en) * | 2011-06-30 | 2011-11-02 | 武汉同源药业有限公司 | Large volume injection composition containing vinpocetine and preparation method thereof |
CN102327210A (en) * | 2011-07-14 | 2012-01-25 | 海南灵康制药有限公司 | Vinpocetine suspension injection |
CN102423295A (en) * | 2011-06-30 | 2012-04-25 | 武汉同源药业有限公司 | Small volume injection composition containing vinpocetine and preparation method thereof |
CN101874776B (en) * | 2009-04-28 | 2012-06-13 | 中国人民解放军军事医学科学院毒物药物研究所 | Dry emulsion of vinpocetine and preparation method thereof |
CN102716066A (en) * | 2011-11-14 | 2012-10-10 | 河南润弘制药股份有限公司 | Vinpocetine injection and preparation method thereof |
CN102716067A (en) * | 2011-11-14 | 2012-10-10 | 河南润弘制药股份有限公司 | Vinpocetine injection and production method thereof |
CN102716064A (en) * | 2011-11-14 | 2012-10-10 | 河南润弘制药股份有限公司 | Vinpocetine injection and production method thereof |
CN102716125A (en) * | 2011-11-14 | 2012-10-10 | 河南润弘制药股份有限公司 | Vinpocetine composition and preparation method thereof |
CN105878178A (en) * | 2014-10-16 | 2016-08-24 | 山西国润制药有限公司 | Vinpocetine injection and preparation method thereof |
TWI619716B (en) * | 2011-07-13 | 2018-04-01 | 江蘇恆瑞醫藥股份有限公司 | Pharmaceutical composition of temozolomide comprising vitamin c or its derivatives and preparation method thereof |
CN110179745A (en) * | 2018-07-16 | 2019-08-30 | 北京海浈医药科技有限公司 | A kind of Vinpocetine injection and preparation method thereof |
-
2006
- 2006-09-28 CN CNB2006101525144A patent/CN100522163C/en active Active
Cited By (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101264064B (en) * | 2008-04-17 | 2011-04-20 | 孙向阳 | Vinpocetine freeze-dried powder for injection and preparation thereof |
CN101874776B (en) * | 2009-04-28 | 2012-06-13 | 中国人民解放军军事医学科学院毒物药物研究所 | Dry emulsion of vinpocetine and preparation method thereof |
CN101889978B (en) * | 2010-04-29 | 2012-01-04 | 袁璐 | Pharmaceutical composition containing vinpocetine, preparation method and application thereof |
CN101889978A (en) * | 2010-04-29 | 2010-11-24 | 袁璐 | Pharmaceutical composition containing vinpocetine, preparation method and application thereof |
CN102160853A (en) * | 2011-02-11 | 2011-08-24 | 方宝林 | Vinpocetine injection and preparation method thereof |
CN102423295B (en) * | 2011-06-30 | 2013-03-13 | 武汉同源药业有限公司 | Small volume injection composition containing vinpocetine and preparation method thereof |
CN102228428A (en) * | 2011-06-30 | 2011-11-02 | 武汉同源药业有限公司 | Large volume injection composition containing vinpocetine and preparation method thereof |
CN102423295A (en) * | 2011-06-30 | 2012-04-25 | 武汉同源药业有限公司 | Small volume injection composition containing vinpocetine and preparation method thereof |
CN102228428B (en) * | 2011-06-30 | 2012-10-03 | 武汉同源药业有限公司 | Large volume injection composition containing vinpocetine and preparation method thereof |
TWI619716B (en) * | 2011-07-13 | 2018-04-01 | 江蘇恆瑞醫藥股份有限公司 | Pharmaceutical composition of temozolomide comprising vitamin c or its derivatives and preparation method thereof |
CN102327210A (en) * | 2011-07-14 | 2012-01-25 | 海南灵康制药有限公司 | Vinpocetine suspension injection |
CN102716067A (en) * | 2011-11-14 | 2012-10-10 | 河南润弘制药股份有限公司 | Vinpocetine injection and production method thereof |
CN102716125A (en) * | 2011-11-14 | 2012-10-10 | 河南润弘制药股份有限公司 | Vinpocetine composition and preparation method thereof |
CN102716064A (en) * | 2011-11-14 | 2012-10-10 | 河南润弘制药股份有限公司 | Vinpocetine injection and production method thereof |
CN102716064B (en) * | 2011-11-14 | 2014-04-09 | 河南润弘制药股份有限公司 | Vinpocetine injection and production method thereof |
CN102716066B (en) * | 2011-11-14 | 2014-04-16 | 河南润弘制药股份有限公司 | Vinpocetine injection and preparation method thereof |
CN102716067B (en) * | 2011-11-14 | 2014-12-10 | 河南润弘制药股份有限公司 | Vinpocetine injection and production method thereof |
CN102716066A (en) * | 2011-11-14 | 2012-10-10 | 河南润弘制药股份有限公司 | Vinpocetine injection and preparation method thereof |
CN105878178A (en) * | 2014-10-16 | 2016-08-24 | 山西国润制药有限公司 | Vinpocetine injection and preparation method thereof |
CN110179745A (en) * | 2018-07-16 | 2019-08-30 | 北京海浈医药科技有限公司 | A kind of Vinpocetine injection and preparation method thereof |
CN110179745B (en) * | 2018-07-16 | 2021-09-10 | 北京海浈医药科技有限公司 | Vinpocetine injection and preparation method thereof |
Also Published As
Publication number | Publication date |
---|---|
CN100522163C (en) | 2009-08-05 |
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