CN101054360A - Method for preparing N-substituted acryloyl-2,5-pyrrole-dione compound - Google Patents
Method for preparing N-substituted acryloyl-2,5-pyrrole-dione compound Download PDFInfo
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Abstract
The present invention relates to a preparation method of N-Substituted-2, 5-pyrrole dione compounds shown as formula (II), which includes: performing out chlorination reaction of substituted alpha, beta-unsaturated acid shown as formula (I) with solid phosgene in presence of organic amine catalyst at 0 to 150 DEG C in ion liquid for 1 to 5h , then adding succinimides compounds to perform amidation at 0 to 150 DEG C for 1 to 3h, generating said compounds through separating and purifying the resultant of reaction, wherein R is alkyl from C1 to C20 or aromatic radical from C6 to C20 in formula (I) and formula (II). The method of present invention has advantages of simply operating, less environment pollution and high yield, in which ion liquid can be reclaimed and recycled, and it is suitable for large-scale industrial production.
Description
(1) technical field
The present invention relates to a kind of N-substituted acryl-2, the preparation method of 5-pyrrole-dione compound.
(2) background technology
N-substituted acryl-2, the 5-pyrrole-dione compound is being with a wide range of applications aspect synthesis of chiral medicine and the natural goods.Aspect biological activity, contain the compound of pyrroledione structure, be the important intermediate of sterilant, weedicide and the class medicine that kills mouse.This reaction substrate can be used as the dienophile of Diels-Alder reaction, the diene body of Hetero Diels-Alder reaction, the receptor of Michael addition reaction.Have the carbonyl of acyl group and beta-unsaturated ketone to exist in the structure, Lewis acid carbonyl easy and acyl group and beta-unsaturated ketone forms the coordination of bidentate type, helps the control of reaction surface.After reaction finished, amide group was easily sloughed again, also can carry out the transformationreation of functional group, complex functionality chipal compounds according to its chemical property.Therefore, N-substituted acryl-2, the 5-pyrrole-dione compound has higher using value.
At present, the N-substituted acryl-2 that relates among the present invention, the synthetic method of 5-pyrrole-dione compound is that beta-unsaturated acid makes corresponding acyl chlorides earlier, reacts under the effect of alkali with the succimide compounds to make again by the α that replaces.Process at the preparation acyl chlorides has been used sulfur oxychloride and phosphorus chloride etc. as chloride reagent, produces a large amount of waste water and waste residue in the reaction, and it is very big to the pollution of environment to carry out suitability for industrialized production, and product yield is lower.
(3) summary of the invention
The purpose of this invention is to provide a kind of N-substituted acryl-2, the clean production method of 5-pyrrole-dione compound, the three wastes are few, the yield height, synthesis technique is simple to operate, is easy to control.
The technical solution used in the present invention is as follows:
N-substituted acryl-2 shown in a kind of formula (II); the preparation method of 5-pyrrole-dione compound; suc as formula the replacement α shown in (I); beta-unsaturated acid is in ionic liquid; the organic amine catalyst action descends and solid phosgene carried out acyl chloride reaction 1～5 hour in 0～150 ℃; adding the succimide compounds again in 0～150 ℃ of amidate action 1～3 hour, is described compound with the product separation and purification
Reaction formula is as follows:
R is the alkyl of C1～C20 or the aryl of C6～C20 in formula (I), the formula (II).
Described ionic liquid is one of following: ion liquid of quaternaries shown in pyridine salt or the formula V shown in imidazole salt shown in the formula (III), the formula (IV),
In formula (III)～formula V, R
1, R
6, R
11Be hydrogen atom or phenyl ring; R
2～R
5, R
7～R
10, R
12～R
14Independent separately is the alkyl of hydrogen atom or C1～C18, and L is BF
4, PF
6, OA
C, CF
3SO
3Or N (SO
2CF
3)
2, described replacement α, beta-unsaturated acid: solid phosgene: succimide compounds: the amount of substance ratio of organic amine catalyzer is 1: 0.4～1: 0.4～3: 0.4～3.The succimide compounds refers to succimide or replaces succimide, and substituting group is often referred to alkyl or aryl.
Solid phosgene has another name called triphosgene, and chemical name is two (trichloromethyl) carbonic ether, and molecular formula is C
3Cl
6O
3, molecular weight 296.75, structural formula are suc as formula (VI):
Further, described organic amine catalyzer is one of following: acid amides, pyridine or triethylamine, preferred triethylamine; Described ionic liquid is 1-alkyl-3-methyl imidazolium tetrafluoroborate or 1-alkyl-3-Methylimidazole hexafluorophosphate, is preferably 1-butyl-3-methyl imidazolium tetrafluoroborate or 1-ethyl-3-methyl imidazolium tetrafluoroborate or 1-butyl-3-Methylimidazole hexafluorophosphate or 1-ethyl-3-Methylimidazole hexafluorophosphate; Ion liquid consumption is every mole of replacement α, and beta-unsaturated acid is with 100～1000 milliliters, and preferred every mole replaces α, and beta-unsaturated acid is with 500 milliliters.
Described separation and purification adds the suitable quantity of water dilution for reaction product is cooled to room temperature, uses ethyl acetate extraction 1～3 time; collect ethyl acetate layer; (ethyl acetate: sherwood oil V/V=1: 10), separation and purification gets N-substituted acryl-2, the 5-pyrrole-dione compound to concentrate the back column chromatography.
Concrete; described preparation method carries out according to following steps: be replacement α according to the amount of substance ratio; beta-unsaturated acid: solid phosgene: succimide compounds: triethylamine is 1: 0.4: 2: 1 feeds intake; (consumption is the α of every mole of replacement at ionic liquid earlier; beta-unsaturated acid is with 500 milliliters) in; replace α; beta-unsaturated acid and solid phosgene carried out acyl chloride reaction 3～5 hours in 90～110 ℃ under the organic amine catalyst action; be cooled to room temperature; add the succimide compounds again in 90～110 ℃ of amidate action 1～3 hour; be cooled to room temperature; add the suitable quantity of water dilution, use ethyl acetate extraction 3 times, collect ethyl acetate layer; (ethyl acetate: sherwood oil V/V=1: 10) separation and purification gets N-substituted acryl-2, the 5-pyrrole-dione compound to concentrate the back column chromatography.
The present invention compared with prior art, its beneficial effect is embodied in:
Method of the present invention is simple to operation, and environmental pollution is less, the yield height, and ionic liquid is recyclable to be applied mechanically, and is fit to carry out large-scale industrial production.
(4) embodiment:
Below with specific embodiment technical scheme of the present invention is described, but protection scope of the present invention is not limited thereto:
Embodiment 1 N-cinnamoyl-2, the preparation of 5-pyrroledione
In reaction vessel, add styracin 1.48g (0.01 mole), catalyst of triethylamine 1g (0.01 mole), solid phosgene 1.2 grams (0.004 mole), 5 milliliters of 1-butyl-3-methyl imidazolium tetrafluoroborate stir, and slowly heat up 90 ℃, reacted 5 hours, cool to room temperature stirs adding succimide 1.98g (0.02 mole) down, 90 ℃ of reactions 1 hour, be cooled to room temperature, add 100 ml waters, ethyl acetate layer is collected in 50 * 3 milliliters of extractions of ethyl acetate, (ethyl acetate: sherwood oil V/V=1: 10) separation and purification gets product 1.6g, yield 70% to concentrate the back column chromatography.Mp?116～118℃。IR(KBr)：2943，1794，1728，1684，1663，1447，1442，1188，1056，995cm
-1.
1H?NMR(CDCl
3)：δ：2.87(s，4H)，7.03(d，J＝15.6Hz，1H)，7.38～7.46(m，3H)，7.59～7.63(m，2H)，7.92(d，J＝15.6Hz，1H)；
13CNMR(CDCl
3)：δ：176.2，166.0，147.7，134.2，131.9，129.5，129.2，128.7，128.5，121.2，29.4；MS?m/z：229(M
+，9.89)。
Embodiment 2 N-cinnamoyl-2, the preparation of 5-pyrroledione
In reaction vessel, add styracin 1.48g (0.01 mole), catalyst of triethylamine 1g (0.01 mole), solid phosgene 1.2 grams (0.004 mole), 5 milliliters of 1-butyl-3-Methylimidazole hexafluorophosphate stir, and slowly heat up 110 ℃, reacted 2 hours, cool to room temperature stirs adding succimide 1.98g (0.02 mole) down, 110 ℃ of reactions 3 hours, be cooled to room temperature, add 100 ml waters, ethyl acetate layer is collected in 50 * 3 milliliters of extractions of ethyl acetate, (ethyl acetate: sherwood oil V/V=1: 10) separation and purification gets product 1.7g, yield 80% to concentrate the back column chromatography.Mp?116～118℃。IR(KBr)：2943，1794，1728，1684，1663，1447，1442，1188，1056，995cm
-1.
1H?NMR(CDCl
3)：δ：2.87(s，4H)，7.03(d，J＝15.6Hz，1H)，7.38～7.46(m，3H)，7.59～7.63(m，2H)，7.92(d，J＝15.6Hz，1H)；
13CNMR(CDCl
3)：δ：176.2，166.0，147.7，134.2，131.9，129.5，129.2，128.7，128.5，121.2，29.4；MS?m/z：229(M
+，9.89)。
Embodiment 3 N-crotonoyl-2, the preparation of 5-pyrroledione
In reaction vessel, add Ba Dousuan 0.86g (0.01 mole), catalyzer pyridine 0.8g (0.01 mole), solid phosgene 2.4 grams (0.008 mole), 10 milliliters of 1-ethyls-3-methyl imidazolium tetrafluoroborate stir, and slowly heat up 100 ℃, reacted 5 hours, cool to room temperature stirs adding succimide 1.98g (0.02 mole) down, 100 ℃ of reactions 3 hours, be cooled to room temperature, add 100 ml waters, ethyl acetate layer is collected in 50 * 3 milliliters of extractions of ethyl acetate, (ethyl acetate: sherwood oil V/V=1: 10) separation and purification gets product 1.38 grams, productive rate 83% to concentrate the back column chromatography.m.p.109～111℃。IR(KBr)：2945，1801，1731，1692，1631，1440，1416，1331，1288，1256，1185，1140，1100，969cm
-1。
1H?NMR(CDCl
3)：δ：1.99(dd，J＝1.7，7.2Hz，3H)，2.82(m，4H)，6.42(dd，J＝1.7，15.4Hz，1H)，7.22～7.26(m，1H).
13C?NMR(CDCl
3)：δ：19.1，29.0，125.0，150.6，164.4，174.3，175.0；MS?m/z：168(M
++1，6.6)，139(24)，69(100)，68(43.6)，55(13.23％)，41(60.81％)。
Embodiment 4 N-hexenoyl-2, the preparation of 5-pyrroledione
In reaction vessel, add 2-hexenoic acid 1.14g (0.01 mole), catalyst of triethylamine 3g (0.03 mole), solid phosgene 3 grams (0.01 mole), 5 milliliters of 1-butyl-3-benzylacetate stir, and slowly heat up 100 ℃, reacted 3 hours, cool to room temperature stirs adding succimide 2.98g (0.03 mole) down, 100 ℃ of reactions 3 hours, be cooled to room temperature, add 100 ml waters, ethyl acetate layer is collected in 50 * 3 milliliters of extractions of ethyl acetate, (ethyl acetate: sherwood oil V/V=1: 10) separation and purification gets product 1.7g, yield 84% to concentrate the back column chromatography.IR(film)：1803，1734，1695，1632cm
-1.
1H?NMR(CDCl
3)：δ：0.94(t，J＝7.5Hz，3H)，1.52(m，2H)，2.26(m，2H)，2.80(s，4H)，6.37(d，J＝15.4Hz，1H)，7.21(dt，J＝15.9，7.1Hz，1H).
13C?NMR(CDCl
3)：δ：14.2，21.6，29.2，35.3，123.8，155.4，164.7，175.2.MS?m/z：195(M
+，24.2)。
Nitro cinnamoyl-2 between embodiment 5 N-, the preparation of 5-pyrroledione
In reaction vessel, add m-nitro-cinnamic acid 1.93 grams (0.01 mole), catalyst of triethylamine 2 grams (0.02 mole), solid phosgene 1.8 gram (0.006 mole), 5 milliliters of 1-butyl-3-N-Methylimidazoleacetic salt stir, slowly heat up 100 ℃, reacted 3 hours, and be cooled to room temperature, add 100 ml waters, 50 * 3 milliliters of extractions of ethyl acetate, collect ethyl acetate layer, (ethyl acetate: sherwood oil V/V=1: 10) separation and purification gets product 1.91g, yield 70% to concentrate the back column chromatography.mp164～166℃。IR(KBr)：3075，1808，17350，1695，1528，1352，1304，1170，1164，1098，964cm
-1.
1H?NMR(CDCl
3)：δ：2.85(s，4H)，7.05(d，J＝15.7Hz，1H)，7.24(d，J＝15.9Hz，1H)，7.47～8.13(m，3H)，8.22～8.41(m，1H)。MSm/z：274(M
+，15.6)。
The preparation of embodiment 6 N-hexenoyl phthalic imidines
In reaction vessel, add 2-hexenoic acid 1.14g (0.01 mole), catalyzer pyridine 1.6g (0.02 mole), solid phosgene 1.2 grams (0.004 mole), 10 milliliters of 1-ethyls-3-Methylimidazole hexafluorophosphate stir, and slowly heat up 150 ℃, reacted 2 hours, cool to room temperature stirs adding phthalic imidine 2.94g (0.02 mole) down, 10 ℃ of reactions 3 hours, be cooled to room temperature, add 100 ml waters, ethyl acetate layer is collected in 50 * 3 milliliters of extractions of ethyl acetate, (ethyl acetate: sherwood oil V/V=1: 10) separation and purification gets product 1.84g, yield 76% to concentrate the back column chromatography.mp107～109℃。IR(KBr)：3441，2958，1796，1752，1688，1636，1465，1329，1282，1191，1145，1036，999cm
-1。
1H?NMR(CDCl
3)：δ：0.98(t，J＝7.4Hz，3H)，1.54～1.60(m，2H)，2.32(dd，J＝1.4，7.3Hz，2H)，6.73(d，J＝15.3Hz，1H)，7.28～7.32(m，1H)，7.83(dd，J＝3.0，5.5Hz，2H)，7.97(dd，J＝3.0，5.5Hz，2H).MS?m/z：243(M
+，9.59)。
The preparation of embodiment 7 N-crotonoyl phthalic imidines
In reaction vessel, add Ba Dousuan 0.86g (0.01 mole), catalyst of triethylamine 1 gram (0.01 mole), solid phosgene 1.2 grams (0.004 mole), 5 milliliters of 1-butyl-3-methyl imidazolium tetrafluoroborate stir, and slowly heat up 100 ℃, reacted 5 hours, cool to room temperature stirs adding phthalic imidine 2.94g (0.02 mole) down, 100 ℃ of reactions 1 hour, be cooled to room temperature, add 100 ml waters, ethyl acetate layer is collected in 50 * 3 milliliters of extractions of ethyl acetate, (ethyl acetate: sherwood oil V/V=1: 10) separation and purification gets product 1.66g, yield 77% to concentrate the back column chromatography.mp124～126℃。IR(KBr)：2923，1744，1685，1638，1466，1446，1324，1285，1192，1142，1038，958cm
-1。
1H?NMR(CDCl
3)：δ：1.95(d，J＝7.0Hz，3H)，6.68(d，J＝15.2Hz，1H)，7.20～7.27(m，1H)，7.77(dd，J＝2.6，5.2Hz，2H)，7.91(dd，J＝2.8，5.2Hz?2H)；
13C?NMR(CDCl
3)：δ：168.4，168.2，141.7，134.0，130.9，128.7，128.0，123.7，123.3，18.8；MS?m/z：215(M
+，6.72)，187(42.28)，130(9.36)，76(10.97)，69(100)，68(56.72)，41(42.12％)。
The preparation of embodiment 8 N-cinnamoyl phthalic imidines
In reaction vessel, add styracin 1.5g (0.01 mole), catalyst of triethylamine 1 gram (0.01 mole), solid phosgene 1.2 grams (0.004 mole), 5 milliliters of 1-butyl-3-methyl imidazolium tetrafluoroborate stir, and slowly heat up 100 ℃, reacted 5 hours, cool to room temperature stirs adding phthalic imidine 2.94g (0.02 mole) down, 100 ℃ of reactions 1 hour, be cooled to room temperature, add 100 ml waters, ethyl acetate layer is collected in 50 * 3 milliliters of extractions of ethyl acetate, (ethyl acetate: sherwood oil V/V=1: 10) separation and purification gets product 2.06g, yield 74% to concentrate the back column chromatography.mp119～120℃。IR(KBr)：2922，2857，1794，1739，1677，1614，1505，1320，1285，1180，1141，1056，986cm
-1.
1H?NMR(CDCl
3)：δ：7.38～7.44(m，4H)，7.64～7.66(m，2H)，7.85～7.87(m，2H)，7.97～8.01(m，3H).
13CNMR(CDCl
3)：δ：165.5，163.6，147.7，135.3，134.0，131.1，131.0，128.8，128.7，124.3，119.3；MS?m/z：277(M
+，9.54)。
The preparation of embodiment 9 N-cinnamoyl phthalic imidines
In reaction vessel, add styracin 1.5g (0.01 mole), catalyst of triethylamine 1 gram (0.01 mole), solid phosgene 1.2 grams (0.004 mole), 5 milliliters of 1-butyl-3-methyl imidazolium tetrafluoroborate stir, and slowly heat up 100 ℃, reacted 5 hours, cool to room temperature stirs adding phthalic imidine 2.94g (0.02 mole) down, 100 ℃ of reactions 1 hour, be cooled to room temperature, add 100 ml waters, ethyl acetate layer is collected in 50 * 3 milliliters of extractions of ethyl acetate, (ethyl acetate: sherwood oil V/V=1: 10) separation and purification gets product 2.06g, yield 74% to concentrate the back column chromatography.mp119～120℃。IR(KBr)：2922，2857，1794，1739，1677，1614，1505，1320，1285，1180，1141，1056，986cm
-1.
1H?NMR(CDCl
3)：δ：7.38～7.44(m，4H)，7.64～7.66(m，2H)，7.85～7.87(m，2H)，7.97～8.01(m，3H).
13CNMR(CDCl
3)：δ：165.5，163.6，147.7，135.3，134.0，131.1，131.0，128.8，128.7，124.3，119.3；MS?m/z：277(M
+，9.54)。
The preparation of nitro cinnamoyl phthalic imidine between embodiment 10 N-
In reaction vessel, add m-nitro-cinnamic acid 1.93g (0.01 mole), catalyst of triethylamine 1 gram (0.01 mole), solid phosgene 1.2 grams (0.004 mole), 5 milliliters of 1-butyl-3-methyl imidazolium tetrafluoroborate stir, and slowly heat up 100 ℃, reacted 5 hours, cool to room temperature stirs adding phthalic imidine 2.94g (0.02 mole) down, 100 ℃ of reactions 1 hour, be cooled to room temperature, add 100 ml waters, ethyl acetate layer is collected in 50 * 3 milliliters of extractions of ethyl acetate, (ethyl acetate: sherwood oil V/V=1: 10) separation and purification gets product 2.07g, yield 64% to concentrate the back column chromatography.Mp?169～172℃。IR(KBr)：3209，1796，1752，1687，1616，1525，1329，1284，1138，712，655cm
-1.
1H?NMR(CDCl
3)：δ：7.28(d，J＝15.5Hz，1H)，7.44(d，J＝15.6Hz，1H)，7.74～8.52(m，8H)；MS?m/z：322(M
+，6.97％)。
Embodiment 11 N-are to the preparation of nitro cinnamoyl phthalic imidine
In reaction vessel, adding is to nitrocinnamic acid 1.93g (0.01 mole), catalyst of triethylamine 1 gram (0.01 mole), solid phosgene 1.2 grams (0.004 mole), 5 milliliters of 1-butyl-3-methyl imidazolium tetrafluoroborate stir, and slowly heat up 100 ℃, reacted 5 hours, cool to room temperature stirs adding phthalic imidine 2.94g (0.02 mole) down, 100 ℃ of reactions 1 hour, be cooled to room temperature, add 100 ml waters, ethyl acetate layer is collected in 50 * 3 milliliters of extractions of ethyl acetate, (ethyl acetate: sherwood oil V/V=1: 10) separation and purification gets product 2.0g, yield 63% to concentrate the back column chromatography.Mp?215～217℃。IR(KBr)：3105，1797，1739，1703，1619，1593，1516，1412，1342，1274，1181，1137，1020，863cm
-1。
1HNMR(CDCl
3)：δ：7.57(d，J＝15.6Hz，1H)，7.80(d，J＝8.3Hz，2H)，7.89(t，J＝2.6Hz，2H)，7.98(d，J＝15.9Hz，1H)，8.02(d，J＝3.1Hz，2H)，8.29(d，J＝8.1Hz，2H).
13CNMR(CDCl
3)：δ：165.9，163.7，148.7，143.0，140.8，136.1，131.6，130.0，125.2，124.6，124.5，124.3；MS?m/z：322(M
+，28.28)，102(100)。
Claims (9)
1. the N-substituted acryl-2 shown in the formula (II); the preparation method of 5-pyrrole-dione compound; it is characterized in that described method carries out as follows: suc as formula the replacement α shown in (I); beta-unsaturated acid is in ionic liquid; the organic amine catalyst action descends and solid phosgene carried out acyl chloride reaction 1～5 hour in 0～150 ℃; add the succimide compounds again in 0～150 ℃ of amidate action 1～3 hour; the reaction product separation and purification is promptly got described compound, formula (I); R is the alkyl of C1～C20 or the aryl of C6～C20 in the formula (II).
2. N-substituted acryl-2 as claimed in claim 1, the preparation method of 5-pyrrole-dione compound is characterized in that described ionic liquid is: pyridine salt shown in imidazole salt shown in the formula (III), the formula (IV) or the ion liquid of quaternaries shown in the formula;
In formula (III)～formula V, R
1, R
6, R
11Independent separately is hydrogen or phenyl ring; L is BF
4, PF
6, OAC, CF
3SO
3Or N (SO
2CF
3)
2R
1～R
5, R
7～R
10, R
12～R
14Independent separately is the alkyl of hydrogen atom or C1～C18.
3. N-substituted acryl-2 as claimed in claim 1; the preparation method of 5-pyrrole-dione compound; it is characterized in that described replacement α; beta-unsaturated acid: solid phosgene: succimide compounds: the amount of substance ratio of organic amine catalyzer is 1: 0.4～1: 0.4～3: 0.4～3; described ion liquid consumption is every mole and replaces α that beta-unsaturated acid is with 100～1000 milliliters.
4. N-substituted acryl-2 as claimed in claim 1, the preparation method of 5-pyrrole-dione compound is characterized in that described organic amine catalyzer is one of following: acid amides, pyridine or triethylamine.
5. N-substituted acryl-2 as claimed in claim 4, the preparation method of 5-pyrrole-dione compound is characterized in that described organic amine catalyzer is a triethylamine.
6. N-substituted acryl-2 as claimed in claim 2, the preparation method of 5-pyrrole-dione compound is characterized in that described ionic liquid is 1-alkyl-3-methyl imidazolium tetrafluoroborate or 1-alkyl-3-Methylimidazole hexafluorophosphate.
7. N-substituted acryl-2 as claimed in claim 6; the preparation method of 5-pyrrole-dione compound is characterized in that described ionic liquid is one of following: 1-butyl-3-methyl imidazolium tetrafluoroborate, 1-ethyl-3-methyl imidazolium tetrafluoroborate, 1-butyl-3-Methylimidazole hexafluorophosphate or 1-ethyl-3-Methylimidazole hexafluorophosphate.
8. N-substituted acryl-2 as claimed in claim 3, the preparation method of 5-pyrrole-dione compound, it is characterized in that described replacement α, beta-unsaturated acid: solid phosgene: succimide compounds: the amount of substance ratio of organic amine catalyzer is 1: 0.4: 2: 1; Described ion liquid consumption is every mole and replaces α that beta-unsaturated acid is with 500 milliliters.
9. N-substituted acryl-2 as claimed in claim 1, the preparation method of 5-pyrrole-dione compound is characterized in that described acyl chloride reaction temperature is that 90～110 ℃, reaction times are 3～5 hours; The amidate action temperature is that 90～110 ℃, reaction times are 1～3 hour.
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| CN103833622A (en) * | 2012-11-26 | 2014-06-04 | 海洋王照明科技股份有限公司 | Maleimide ionic liquid, and preparation method and application thereof |
| CN104607099A (en) * | 2015-01-16 | 2015-05-13 | 齐齐哈尔大学 | (3, 3'-p-phenylenediamine formoxyl) bis-N-alkyl pyridine bromide surfactant and preparation method thereof |
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| GB1496879A (en) * | 1973-12-21 | 1978-01-05 | Laporte Industries Ltd | Compositions and process for the treatment of cellulosic materials |
| JPH0665197A (en) * | 1992-06-19 | 1994-03-08 | Dai Ichi Seiyaku Co Ltd | Production of pyrrolidinylacetamide derivative |
| CN1288132C (en) * | 2003-06-24 | 2006-12-06 | 浙江工业大学 | Chemical synthesis of 1-chloroformyl succinimide |
| CN1562936A (en) * | 2004-04-14 | 2005-01-12 | 国家海洋局杭州水处理技术研究开发中心 | New technique for preparing oxyformyl chloride-isophthaloyl chlorine |
| CN1680316A (en) * | 2005-01-19 | 2005-10-12 | 浙江工业大学 | Preparation of imide unsaturated ketone |
-
2007
- 2007-05-23 CN CN200710068881A patent/CN100593538C/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103833622A (en) * | 2012-11-26 | 2014-06-04 | 海洋王照明科技股份有限公司 | Maleimide ionic liquid, and preparation method and application thereof |
| CN103833622B (en) * | 2012-11-26 | 2016-04-20 | 海洋王照明科技股份有限公司 | Maleimide ionic liquid and its preparation method and application |
| CN104607099A (en) * | 2015-01-16 | 2015-05-13 | 齐齐哈尔大学 | (3, 3'-p-phenylenediamine formoxyl) bis-N-alkyl pyridine bromide surfactant and preparation method thereof |
| CN104607099B (en) * | 2015-01-16 | 2016-06-29 | 齐齐哈尔大学 | (3,3 '-to diamino-benzene formoxyl) double; two N-alkyl pyridine bromine salt surfactants and preparation method thereof |
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