CN101052703A - Method of inhibiting the adherence of lenses to surfaces during their manufacture - Google Patents

Abstract

Methods of reducing the adherence of soft contact lenses to hydrophobic packing materials.

Description

Suppress eyeglass in the mill to the adhering method in surface

The present invention relates to make the method for contact lenses.

Related application

This application is a unsettled U.S. Patent application of submitting on November 5th, 2004, U.S.SerialNo.10/982,297 part continuation application.

Background technology

Since the 1950's contact lenses be used to improve eyesight commercial.First contact lenses is made by mechanically resistant material.Although these eyeglasses are also using now, because their relatively poor initial comfortablenesses, they are not suitable for all patients.In the development subsequently of this field, produced SCL, its hydrogel to popularize very much in today.These eyeglasses have higher oxygen-permeable and therefore wear more comfortable than the contact lenses of being made by mechanically resistant material.Yet these new eyeglasses are had no time no all roses.

Have that the contact lenses of high oxygen permeability made by hydrophobic material typically.The packing that is used for contact lenses is also made by hydrophobic material.When a hydrophobic surface contacted with another hydrophobic surface, the surface was adhering to each other.The adhesion of a contact lenses and its packing produces many problems.The first, the soft lens that packing ratio is included in the inside is thicker and harder.If eyeglass adheres on the packaging, when the user attempts to take out eyeglass, eyeglass is usually torn and must be abandoned.When these eyeglasses are manufactured, can present problem, not damage eyeglass because eyeglass must be transferred to their final packings from the processing station of their upstreams.A method that addresses this problem is eyeglass packing to be full of packaging solution or water stops the adhesion of eyeglass to packing.Yet if this solution is only had an effect when the step upstream of manufacturing processed provides the additional solutions of packing, and usually because manufacturing system regulation parameter, solution just can be added after eyeglass is in the packing.Therefore need a kind of contact lenses that suppresses to the adhering method of their packing and eyeglass need not be added and be full of in the packing of solution.Thisly need have been satisfied by following invention.

Detailed description of the invention

The present invention includes a kind of method that soft lens is transferred to hydrophobic packing materials, be included in soft lens be transferred to before the described packing lubricating fluid is applied to the hydrophobicity packing, basically by or form by before soft lens is transferred to described packing, lubricating fluid being applied to the hydrophobicity packing, wherein lubricating fluid comprises a kind of suitable tensio-active agent of significant quantity.

Here use, " lubricating fluid " of the present invention can be a kind of be based solutions with water.Typical solutions comprises salts solution, other buffered soln and deionized water ad lib.The preferred aqueous solution is deionized water or saliniferous salts solution, comprises sodium-chlor, Sodium Tetraborate, sodium phosphate, sodium hydrogen phosphate, SODIUM PHOSPHATE, MONOBASIC or corresponding same sylvite ad lib.These compositions are combined to form the buffered soln that comprises a kind of acid and its conjugate base usually, change so that the interpolation of bronsted lowry acids and bases bronsted lowry only causes relatively little pH.Buffered soln also can comprise 2-(N-morpholino) methylsulfonic acid (EMS), sodium hydroxide, 2,2-two (methylol)-2,2 ' 2 " nitrilotriethanol, n-three (methylol) methyl-2-aminoethyl sulfonic acid, citric acid, Trisodium Citrate, yellow soda ash, sodium bicarbonate, acetic acid, sodium-acetate, ethylenediamine tetraacetic acid (EDTA) or the like and their combination.Preferably, lubricating fluid is the salt brine solution or the deionized water of borate buffered saline solution or phosphate buffered.

Here the term of Shi Yonging " application " is meant a kind of method that lubricating fluid is contacted hydrophobic packing materials.The example of this method comprises gunite, punching press, scouring, atomizing or gives with lubricating fluid will be near the arbitrary surfaces of the packing rotation dressing hydrophobic packing materials of eyeglass.The preferred method of using lubricating fluid is the internal surface injection in the hydrophobicity packing, must carefully control to spray with the prevention for example excessive solvent of manufacturing issue after a while to overflow or the heat-sealing problem.What therefore preferably only lubricating fluid is applied to pack will be near the surface of eyeglass.The dressing of for example about lubricating fluid of 12 to about 18mg has shown that suppressing its hydrophobicity of soft lens adhesion packs.The timing key of spraying is to obtain evenly the solution of injection in packing, and preferably by a computer control.Ventilation must be opened before pump startup so that pressure-stabilisation.The preferred ventilation at 0.1 second front opening of pump startup, and preferably with about 0.3 second of pump startup.Lubricating fluid is transmitted and ventilates when pumping has been finished and must be switched off the development of doing with prevention simultaneously.The dimensional variation of air pressure, tracheae length or the pump speed of packing all can influence regularly.

Term " significant quantity " is meant and prevents that eyeglass from adhering to the amount (press the weight percent calculating of lubricating fluid gross weight) of the necessary suitable tensio-active agent of their packing.Significant quantity approximately be 0.1% (1000ppm) to about 1.0% (10,000ppm), be more preferably about 0.1% to 0.8%.Most preferred significant quantity is that about 0.3% (3000ppm) is to 0.6% (6000ppm).

Here use, " suitable tensio-active agent " is a kind of can the inhibition the adhesion of hydrophobic packing materials but non-degradable hydrophobic packing materials or the physical parameter that the changes eyeglass tensio-active agent of lens diameter, base curve or water content for example.Preferred suitable tensio-active agent is a methylcellulose gum.Methylcellulose gum be the molecular weight of a kind of polymkeric substance and preferred polymers greater than 750,000 dalton, 1,000,000 dalton more preferably from about.Preferred methylcellulose gum supplier is the M352 trade mark of Fisher Scientific, and it is had the viscosity of 3,000 to 5,600 centipoises by methoxylation 27.5% to 31.5% and its 2% solution.Can attempt using other tensio-active agent, including, but not limited to the tensio-active agent of macrodex, Natvosol, Vltra tears, Walocel MT 20.000PV, hydroxyethylmethyl-cellulose and Glucamate DOE 120 manufacturings.Yet because their interaction or eyeglass (for example having distorted the dimension or and the lens materials interaction of eyeglass) or hydrophobicity packing are not fit in those tensio-active agents.

Here " soft lens " of Shi Yonging is meant and resides in face or the surperficial Ophthalmoligic instrument of eye in the eyes.It maybe can be beauty treatment usefulness that these devices can provide optical correction.The term eyeglass embeds mirror including, but not limited to SCL, ophthalmic lens, outer cover eyeglass, eye with embedding mirror and optics.The preferred eyeglass of the present invention is the SCL of being made by silicone elastomer or hydrogel, and it is including, but not limited to siloxanes aquogel and fluoro hydrogel.The prescription of SCL is disclosed in the US patent No. 5,710,302, WO 9421698, EP 406161, JP 2000016905, the U.S. patent No. 5,998,498, the US number of patent application 09/532,943, the U.S. patent No. 6,087,415, the U.S. patent No. 5,760,100, the U.S. number of patent application 5,776, and 999, U.S. number of patent application 5,789,461, U.S.Pat.No.5,849,811 and the U.S. patent No. 5,965,631.Above-mentioned reference integral body is quoted at this as a reference.The particularly preferred eyeglass of the present invention is to be made by etafilcon A, genfilcon A, galifilcon A, senofilcon A, lenefilcon A, lotrfilcon A, lotrifilcon B, balifilcon A or polymacon.The preferred eyeglass of the present invention is to be made by genfilcon A, galifilcon A, senofilcon A, lenefilcon A, lotrfilcon A, lotrifilcon B or balifilcon A.Most preferred eyeglass is including, but not limited to galifilcon A, senofilcon A and disclosed in U.S number of patent application 60/318,536, title are Biomedical Devices Containing Internal wetting Agents; " September 10 calendar year 2001 open and its non-interim copy of same title, U.S.'s series is applied for No.10/236,538, on September 6th, 2002 is open, the U.S. patent No. 6,087,415, the U.S. patent No. 5,760,100, U.S. the patent No. 5,776, and 999, U.S. the patent No. 5,789,461, the U.S. patent No. 5,849,811 and the U.S. patent No. 5,965,631.These patents and all other disclosed in this application patent integral body are quoted at this as a reference.

" hydrophobic packing materials " is meant the material that was used to prepare the container of making eyeglass before they are used by the final user.Eyeglass be placed on the user in the eyes after wrapping material abandoned by the user.The example of hydrophobic packing materials is including, but not limited to polypropylene, polyethylene, nylon, olefin copolymer, crylic acid resin, rubber, urethane, polycarbonate or fluorocarbon.Preferable material is metallocene polymers and the multipolymer of being made by polypropylene, polyethylene, and it has the extremely flowing scope of melt of about 44g/10min of about 15g/10min of detecting through ASTM D-1238.The container of being made by hydrophobic packing materials can be a lot of forms.These containers can store single eyeglass or many eyeglasses.An example of single eyeglass storing unit is Blister Package, disclosed packing in the publication below for example, U.S. patent No. D435.966S; 4,691,820; 5,467,868; 5,704,468; 5,823,327; 6,050,398, their integral body is quoted at this as a reference.The example of multiple eyeglass storing unit comprises the hydrophobicity model of the contact lenses that is used to produce 4,640,489 demonstrations of the U.S. patent No., and its integral body is quoted at this as a reference.Other example comprises support, or other container in production soft lens process.

Following example is used to illustrate but does not limit the present invention.

Shift eyeglass

Embodiment 1

The monomer mixture that forms galifilcon A contact lenses is solidified between half light mould and half former.With the eyeglass of handling from model, shift out, aquation and inspection.Eyeglass is shifted out from check support.One group of single contact lens packing by the polypropylene manufacturing is placed in a row under the IVEK nozzle.In these nozzles each all has the fluid tip of a nozzle air valve and an inside.Packing is lined up row, starts air valve, and the 10-40psi gas-pressure ring streams inner liquid jet and flows.This air pressure produces stable area of low pressure around liquid jet and 0.43% (4300ppm) methylcellulose gum of very short time precision positive displacement piston-type liquor pump injection is thereafter extremely packed the internal surface that row are coated to this solution of 12-18mg packing at the solution of deionized water.The packing of coating is moved to next processing station and loads moisture eyeglass.None adheres on the packing in the eyeglass.If do not use methocel solution, eyeglass adheres to packing in transfer, and can not be used.After loading eyeglass, add salt packaging solution (950ml is to form the final methylcellulose gum concentration of about 60ppm) and pack continuing to remaining treatment step.

Claims (20)

1. one kind is transferred to the method for hydrophobic packing materials with soft lens, is included in lubricating fluid to be applied to the hydrophobicity packing before soft lens is transferred to described packing, and wherein lubricating fluid comprises a kind of suitable tensio-active agent of significant quantity.

2. the process of claim 1 wherein that described suitable tensio-active agent is a methylcellulose gum.

3. the process of claim 1 wherein that the suitable tensio-active agent of significant quantity is about 0.1% to about 0.8%.

4. the method for claim 3, wherein suitable tensio-active agent is a methylcellulose gum.

5. the process of claim 1 wherein that suitable tensio-active agent is that methylcellulose gum and significant quantity are about 0.3% to about 0.6%.

6. sharp 1 the method that requires, wherein lubricating fluid comprises deionized water.

7. the method for claim 5, wherein lubricating fluid comprises deionized water.

8. the method for claim 5, wherein packaging solution comprises the salt brine solution of borate buffered saline solution or phosphate buffered.

9. the process of claim 1 wherein that suitable tensio-active agent can not distort the physical properties of soft lens.

10. the method for claim 9, wherein suitable tensio-active agent can not distorted diameter, base curve or the water content of soft lens.

11. the method for claim 9, wherein suitable tensio-active agent can not distorted the diameter or the base curve of soft lens.

12. the method for claim 9, wherein suitable tensio-active agent can not distorted the water content of soft lens.

13. the method for claim 9, wherein suitable tensio-active agent can not increase or reduce the water content of soft lens greater than about 1%.

14. the method for claim 9, wherein suitable tensio-active agent can not make the water content of soft lens increase or reduce greater than about 0.8%.

15. the method for claim 13, wherein suitable tensio-active agent is a methylcellulose gum.

16. the process of claim 1 wherein that soft lens comprises genfilcon A, galifilcon A, senofilcon A, lenefilcon A, lotrfilcon A, lotrifilcon B or balifilcon A.

17. the process of claim 1 wherein that soft lens comprises galifilcon A or senofilcon A.

18. the method for claim 9, wherein soft lens comprises galifilcon A or senofilcon A.

19. the method for claim 9, wherein soft lens comprises genfilcon A, galifilcon A, senofilcon A, lenefilcon A, lotrfilcon A, lotrifilcon B or balifilcon A.

20. the method for claim 13, wherein soft lens comprises genfilcon A, galifilcon A, senofilcon A, lenefilcon A, lotrfilcon A, lotrifilcon B or balifilcon A.