CN101041016B - Medicine for curing pituitary adenoma and its preparation method - Google Patents
Medicine for curing pituitary adenoma and its preparation method Download PDFInfo
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- CN101041016B CN101041016B CN2007100130984A CN200710013098A CN101041016B CN 101041016 B CN101041016 B CN 101041016B CN 2007100130984 A CN2007100130984 A CN 2007100130984A CN 200710013098 A CN200710013098 A CN 200710013098A CN 101041016 B CN101041016 B CN 101041016B
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Abstract
The invention discloses a medicament for treating hypophysis cancer, which is prepared from fleece-flower root, sophora bud, Dendrobium nobile, polyporus umbellatus, dodder seed, Chinese honeylocust abnormal fruit, apiary and pangolin by a predetermined weight proportions. The medicament can be prepared into any of the conventional oral administration dosage forms.
Description
[technical field]
What the present invention relates to is a kind of medicine for the treatment of pituitary tumor, disease of pituitary gland and subhealth state disease and preparation method thereof, belongs to the field of Chinese medicines.
[background technology]
Hypophysis cerebri be arranged in brain just with the eyes rear, hypophysis cerebri is the general headquarter of human endocrine, control human endocrine function comprises the height of blood glucose, electrolyte, human body, male sex characteristics such as beard, women's menstruation etc. all is a function pituitary.Pituitary tumor belongs to one of cerebroma, is the benign tumor that page or leaf grows out before the hypophysis, and pituitary tumor is divided into lactotroph adenoma (PRL tumor), auxin adenoma (GH tumor), corticoid tumor (ACTH tumor).Need make serum endocrine mensuration makes a definite diagnosis.It mainly shows as intracranial delayed ischemic neurological deficits and endocrine dysfunction two aspects.Delayed ischemic neurological deficits mainly shows as: headache, and compressing optic nerve symptom, typical person is a bitemporal hemianopsia.The PRL tumor shows that mainly the women is amenorrhea, lactogenic, sterile etc.The male is hyposexuality, sexual impotence, weight increase, oligotrichosis etc.The first-selected method surgical removal of treatment is made radiotherapy or Drug therapy now; But it is undesirable that the above two treat aftereffect; The western medicine side effect is big, and the treatment by Chinese herbs potentiality are very big, but existing medicine onset is slow, and effect is also undesirable.Picking up rope in the network goes out the special side's medication of Beijing Traditional Chinese Medicine experts doctor Feng and is: 1 of Spica Prunellae 15g, Flos Eriocauli 10g, Semen Celosiae 6g, Flos Chrysanthemi 10g, structure Fructus Lycii 15g, Radix Salviae Miltiorrhizae 30g, Cortex Lycii 6g, 1 of Scorpio, Radix Rehmanniae 30g, mountain cornel 10g, Rhizoma Dioscoreae 10g, Concha Ostreae 40g, Poria 10g, Radix Sanguisorbae 10g, Ramulus Cinnamomi 3g, Scolopendra.One piece of pertinent literature of patent documentation brother is: 99113149.5 " medical capsule for treating cerebroma and production method "; Its raw material is: Zhu's Wu cornel, Rhizoma Pinelliae, Arisaema Cum Bile, Rhizoma Typhonii, Alumen, Cortex Dictamni, Scorpio, Scolopendra, Bombyx Batryticatus, Rhizoma Cyperi, white shepherd's purse, Colla cornus cervi, Radix Clematidis, sea clam powder, Rhizoma Alismatis, the Rhizoma Atractylodis Macrocephalae, Radix Semiaquilegiae, Rhizoma Zingiberis, Pseudobulbus Cremastrae Seu Pleiones, Rhizoma Dioscoreae Bulbiferae.Writing this medicine exactly controls cerebroma (pituitary tumor only is an one) cure rate and reaches more than 93%.Though we do not verify that this obviously is unrealistic, nor be to treat at pituitary tumor specially.
[summary of the invention]
Still there is demand in Chinese medicine preparation for better special for treating pituitary tumor.Up to now, also do not send out the report of any relevant pharmaceutical composition of the present invention of sorcerer.The inventor is through research repeatedly, and the checking repeatedly by clinical trial, has found the oral medicinal herb medicine that the treatment of better curative effect pituitary tumor is arranged finally, thereby has finished the present invention.
The object of the invention just provides a kind of a kind of Chinese medicine composition of more effectively treating pituitary tumor.
Another one purpose of the present invention has provided the Preparation Method of this Chinese medicine composition.
Medicine of the present invention is selected with Radix Polygoni Multiflori Preparata, Fructus Sophorae, Herba Dendrobii, Polyporus, Semen Cuscutae, Fructus Gleditsiae Abnormalis, system Nidus Vespae, Squama Manis (processed) and Radix Glycyrrhizae combination, make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat other symptom and the subhealth state disease of hypophysis tumor and hypophysis generation.Wherein select for use Radix Polygoni Multiflori to be because Radix Polygoni Multiflori: property is sweet, bitter, puckery, tepor, goes into liver, kidney, the effect the liver and the kidney tonifying, and moistening dryness for relaxing bowels is used for deficiency of the liver and kindey, soreness of the waist and knees.Fructus Sophorae: bitter, be slightly cold, go into liver, large intestine, fry with the cooling blood for hemostasis effect is arranged.Herba Dendrobii: sweet, pray for coldly, enter the market, stomach, kidney channel, clearing away heat and promoting production of body fluid, the effect of clearing stomach preventing or arresting vomiting are arranged, be used for diseases such as deficiency of stomach-Yin, dry mouth with parched lips, the few Tianjin of crimson tongue.Polyporus: sweet, flat, go into kidney, bladder, the promoting diuresis to eliminate damp pathogen effect is arranged.Semen Cuscutae: hot, sweet, flat, go into Liver and kidney, the solid warp of the kidney invigorating, the effect of nourishing the liver item are arranged, be used for impotence due to deficiency of the kidney, lose warp, Fructus Gleditsiae Abnormalis: hot, salty, warm, poisonous, go into lung, kidney, large intestine three warps, there have sensible switching, removing food stagnancy to remove to be full.Nidus Vespae: bitter, salty, sweet, flat, go into lung, spleen, large intestine, tinea, carbuncle etc. are treated in wind dispelling counteracting toxic substances, the swollen pain relieving of loosing.Squama Manis (processed): salty, be slightly cold, go into liver, stomach, promoting blood circulation and detumescence, dredging collateral for promoting lactation, be used for carbuncle from the beginning of or abscess do not burst.Radix Glycyrrhizae: sweet, flat, go into 12 warps, invigorating the spleen and replenishing QI, eliminating fire and detoxication, relieving spasm to stop pain.
In order to reach better therapeutic, the consumption of drug component of the present invention is also groped to sum up to draw through the inventor in a large number, each amounts of components is for all to have better curative effect in the following weight parts scope: Radix Polygoni Multiflori 25-30 part, Fructus Sophorae 29-32 part, Herba Dendrobii 28-34 part, Polyporus 27-33 part, each 26-31 part of Semen Cuscutae, Fructus Gleditsiae Abnormalis 13-16 part, system Nidus Vespae 15-20 part, Squama Manis (processed) 5-10 part, Radix Glycyrrhizae 10-15 part.
Be preferably: 33 parts of Radix Polygoni Multiflori, 29 parts of Fructus Sophorae, 30 parts of Herba Dendrobiis, 27 parts of Polyporus, 28 parts of Semen Cuscutae, 16 parts of Fructus Gleditsiae Abnormalis, 20 parts in Nidus Vespae of system, 10 parts of Squama Manis (processed), 15 parts in Radix Glycyrrhizae.
Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional oral preparations, for example these crude drug pulverize mix homogeneously can be made powder and take after mixing it with water; Can be except that Radix Polygoni Multiflori, Squama Manis, Nidus Vespae with these crude drug, decocting together, the condensed water decocting liquid is mixed and made into and gets final product with the Radix Polygoni Multiflori that makes respectively, Squama Manis, Nidus Vespae powder more then.
Preferably, the preparation method of medicine activity component of the present invention is as follows:
A) Fructus Sophorae, Herba Dendrobii, Polyporus, Semen Cuscutae, Fructus Gleditsiae Abnormalis, the glycyrrhizic liuwei drug with described weight proportion carries out micropowder (about 3um, can adopt oscillating mill by Jinan times power powder technical staff degree company product) decoct with water twice, each amount of water was not advisable to have powder, merge decocting liquid twice, filter to get filtrate 1, be condensed into proportion and be 1.35 extractum, add 90-95% ethanol and carry out precipitate with ethanol, after reclaiming ethanol medicinal liquid is concentrated, dry under 45-50 ℃, make dry extract 1;
B) surplus stock medicine Radix Polygoni Multiflori, Squama Manis, Nidus Vespae are manufactured processing according to the Chinese medicine routine respectively after, adopt oscillating mill (Jinan times power powder technical staff degree company produces) to grind following micropowder (cell wall breaking) for 3um; Add 90 one 95% ethanol and carry out precipitate with ethanol, medicinal liquid is concentrated after reclaiming ethanol, 45-50 ℃ dry down, make in extractum 2.
C) merge dry extract 1 and dry extract 2, the reuse conventional method is made honeyed pill, and every ball 1 restrains, and just has been prepared into the active component of medicine of the present invention.
Instructions about how to take medicine: every ball 1 gram, every days 2, ball was sooner or later respectively obeyed 1 ball on an empty stomach, and 30 balls (15 days) are a course of treatment.Drug effect of the present invention is clearly: at first be the curative effect gratifying to the human endocrine disease; Can treat pituitary tumor or Pituitaryadenoma; The raising immunologic function is arranged, can obviously improve the human-body sub-health illness; To some other difficult miscellaneous diseases, beauty treatment, be that senile plagues etc. also produces effect as eliminating lipofuscin, other function also is worth further research and development.
[specific embodiment]
The clinical observation report of Drug therapy pituitary tumor of the present invention and subhealth state disease is as follows:
Pituitary tumor is prehypophyseal benign tumor, causes that easily the pituitary hormone diacrisis increases, and causes acromegaly, diabetes insipidus, menoxenia or amenorrhea, impotence and premature ejaculation, but late period threat to life.Operation and the radiotherapies of adopting of treatment in the past more, the report of useful pure treatment by Chinese herbs recently, but case is less, curative effect is indefinite, and this group case adopts pure treatment by Chinese herbs, the effect uniqueness;
Case is selected: this group case is totally 30 examples, male 18 examples, women 12 examples, and age 14-42 year, medical history March to 1 year is all through CT, nuclear magnetic resonance, NMR and check prolactin antagonist PRL to be diagnosed as pituitary adenoma.Clinical symptoms: insomnia anxiety, irritated depression, menoxenia, impotence and premature ejaculation; Therapeutic Method:
Criterion of therapeutical effect: cure: transference cure, CT, nuclear magnetic resonance, NMR or PRL are normal or dwindle more than 80%; Take a turn for the better: symptom takes a turn for the better, and CT, nuclear magnetic resonance, NMR or PRL dwindle 50%-79%; Invalid: symptom and inspection do not have obviously change.Curative effect: cure 15 examples, 14 examples that take a turn for the better, effective percentage reaches 96.6%, invalid 1 example, inefficiency 3.4%;
Discuss: the pituitary tumor treatment is difficulty relatively, operation and radiotherapy have certain danger and cost an arm and a leg, Drug therapy pituitary tumor effect of the present invention certainly, low price, no obvious toxic-side effects, Radix Polygoni Multiflori wherein, Herba Dendrobii, Semen Cuscutae, Squama Manis, Radix Glycyrrhizae has invigorating the spleen and replenishing QI, the disorderly effect of the kidney invigorating endocrine regulation obviously improves the insomnia anxiety, obesity is closed, the impotence and premature ejaculation symptom, Fructus Sophorae, Polyporus, the Fructus Gleditsiae Abnormalis heat-clearing and toxic substances removing, the softening the hard mass knot, dwindle the adenoma effect, through clinical verification for many years, evident in efficacy, the patient who has took medicine for 1 week, symptom is obviously improved, this group case effective percentage 96.6% is seen recurrence through following up a case by regular visits to so far the end, is subjected to patient's favorable comment deeply.
Medicine ash model case of the present invention is as follows:
Example 1: Huang Qinghua, woman, 27 years old, amenorrhea in puerperal in May calendar year 2001 oneself 3 years, upright second the People's Hospital diagnosis and treatment through the Shandong Province, readme general weakness, insomnia, obesity, quick-fried alopecia, galactorrhea and hyposexuality, pachylosis has mottle, and audit report is shown: PRL285mg/ml, make a definite diagnosis pituitary tumor; It is invalid to seek medical advice through how tame hospital; Take through medicine of the present invention " hypophysis is flat ", look into the PRL value after three months and be 18.7mg/ml, (normal value: man 01---20; Woman 05-25), year half posterior tuberosity body disappears, menstruation recovery and coloured glaze Gr1 P0 AB1, and it is normal that body weight and desire are recovered, mottle desalination, the rehabilitation of skin organ function, not recurrence so far.
Example 2: Han Shuan, woman, 30 years old, the Shandong doctor of hospital of provincial government, in February, 2000, post-abortion, cracked ends was 5 years, readme general weakness, anorexia, dreaminess, irritated alopecia checks that through Shandong Province institute of traditional Chinese medicine demonstration PRL value is 210mg/ml, examines to be pituitary tumor, invalid through about 5 years of how tame hospital treatments such as provincial hospital, lose confidence; Take back 2 months of the present invention's " hypophysis is flat ", look into the PRL value for 11.7mg/ml, recover fine so far, spirit, muscle power are clearly better, and have done artificial abortion again 3 times.
Example 3, manager Liu, the manager of Dalian food company, man, 59 years old, in July, 2002, big attached institute goes to a doctor at the Dalian medical courses in general, readme: nocturia influences sleep frequently throughout the year, and the mental status is not good, hospital diagnosis is a subhealth state, through failing to respond to any medical treatment in many ways, promptly take effect in a week through taking " hypophysis is flat ", sleep quality obviously improves, libido improves, and is good so far.
Example 4, Li Yuanling, woman, 31 years old, amenorrhea 2 years, galactorrhea, hyposexuality, headache and insomnia is looked into PRL value for 221mg/ml through Jinan City central hospital, is diagnosed as pituitary tumor, treats the too big drug withdrawal of side effect with " Australia Yin Ting ".After take " hypophysis flat " symptom be gradually light after one month, the high lactotropin value of check is 11.7mg/ml after 60 days, many symptoms fade away, menstruation is also normal after half a year.
Example 5: Feng Fanghua, woman, 29 years old begins the mood anxiety in March, 1004, depressed headache, insomnia, it is unable, sombre to mix body, and fail to respond to any medical treatment and take " hypophysis is flat " and take effect in a week in the Shandong Prov. Hospital, and above-mentioned symptom fades away.
Example 6: the plain third constellations, the boss of foreign enterprise of Korea S who stays Yantai, man, 65 years old, tired physically and mentally, to be off one's feed, serious insomnia is diagnosed as subhealth state, imitates, and the emperor top hospitalize of giving birth through the Yantai City is invalid, and suicidal tendency is arranged when irritated.After taking " hypophysis is flat ", symptom fades away, and mood is optimistic.Its madam Song Shi (Chinese) suffers from alopecia, and the libido indifference is refractory always, takes also very fast improvement after " hypophysis flat ", and Mr. and Mrs 2 people value " hypophysis is flat " highly.
Example 7: Yang Hongying, woman, 50 years old, surplus the own dysmenorrhea 20 year, very painful, morbidity is derived from one's early years to live in the cat's-ear-shaped cave, adds due to moist and the high-pressure.Through the Shandong Prov. Hospital, tame hospitalize tens such as the military region, Jinan 90 hospitals is ineffective every year, through taking " hypophysis is flat " month surplus taking effect, glucose recovery is normal, so far recurrence.
Example 8: Ma Zhanshan, man, 45 years old, the cadre of Shandong food company, whole body pain, premature ejaculation, painful uncomfortable; Look into through a few place hospital and to control invalidly, Shandong Province Second Academy prescription on individual diagnosis conclusion bone density reduces and causes that pain is osteoporosis, but fails to respond to any medical treatment, and intends being subhealth state disease.After taking " hypophysis flat " week, symptom takes a turn for the better, serve on 2 months after, each transference cure.
Example 9: Feng Xiaogang, man, 6 years old, the doctor child of Peng Lai municipal hospital, it is surplus to suffer from blood platelet reduction disease 1 year, and the hormone that has Western medicine is in hospital kept, and is ineffective always, imitates, and takes " hypophysis is flat " certainly after the week, takes a turn for the better, so far recurrence.
Example 10: Lee is many, and man, 36 years old picks up through the Shandong Prov. Hospital and to look into, blood platelet reduction, and every getting up early mouthful blood of tut-tuting comes from the teeth space, and after the week, commentariess on classics of getting better took effect after 3 weeks to take " hypophysis is flat " certainly, healed entirely after March, recurred so far.
Oneself is on probation in Beijing for medicine of the present invention, promotes the medicines and health protection Committee of Experts (newly set up mechanism address be located at sea-freight CITIC Building, storehouse, Beijing be Headquarters of the General Staff first hostels) organization of unity to try out, study, develop by the private science and technology of China.Make the faster and better generation social benefit of medicine meeting of the present invention and develop purposes widely.
Claims (3)
1. medicine for the treatment of the hypophysis tumor, it is characterized in that it is to be made by following bulk drugs: Radix Polygoni Multiflori 25-30 part, Fructus Sophorae 29-32 part, Herba Dendrobii 28-34 part, Polyporus 27-33 part, each 26-31 part of Semen Cuscutae, Fructus Gleditsiae Abnormalis 13-16 part, system Nidus Vespae 15-20 part, Squama Manis (processed) 5-10 part, Radix Glycyrrhizae 10-15 part.
2. according to the medicine of claim 1, wherein the consumption of a crude drug is: 33 parts of Radix Polygoni Multiflori, 29 parts of Fructus Sophorae, 30 parts of Herba Dendrobiis, 27 parts of Polyporus, 28 parts of Semen Cuscutae, 16 parts of Fructus Gleditsiae Abnormalis, 20 parts in Nidus Vespae of system, 10 parts of Squama Manis (processed), 15 parts in Radix Glycyrrhizae.
3. the preparation method of claim 1 or 2 described medicines, it comprises the following steps:
A) take by weighing each crude drug Radix Polygoni Multiflori, Fructus Sophorae, Herba Dendrobii, Polyporus, Semen Cuscutae, Fructus Gleditsiae Abnormalis, Nidus Vespae, Squama Manis, Radix Glycyrrhizae are standby;
B) with Fructus Sophorae, Herba Dendrobii, Polyporus, the Semen Cuscutae of described weight ratio, Fructus Gleditsiae Abnormalis, Radix Glycyrrhizae, Six-element medicine mixed powder is broken to cell wall breaking, decocts with water twice, each amount of water was not advisable to have powder, merge decocting liquid twice, precipitation or rotation separate filtrate 1, be condensed into proportion and be 1.35 extractum, add 90-95% ethanol and carry out precipitate with ethanol, after reclaiming ethanol medicinal liquid is concentrated, dry under 45-50 ℃, make dry extract 1;
C) surplus stock medicine Radix Polygoni Multiflori, Squama Manis, Nidus Vespae are manufactured processing according to the Chinese medicine routine respectively after, adopt to grind following micro mist cell breaking cellular wall for 3um; Add 90-95% ethanol and carry out precipitate with ethanol, behind the recovery ethanol medicinal liquid is concentrated, dry under 45-50 ℃, make dry extract 2;
D) merge dry extract 1 and dry extract 2, the reuse conventional method is made honeyed pill, every ball 1 gram.
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| CN2007100130984A CN101041016B (en) | 2007-01-24 | 2007-01-24 | Medicine for curing pituitary adenoma and its preparation method |
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| CN101041016B true CN101041016B (en) | 2011-03-30 |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1246358A (en) * | 1999-08-10 | 2000-03-08 | 辛长山 | Medical capsule for treating cerebroma and its preparing process |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1246358A (en) * | 1999-08-10 | 2000-03-08 | 辛长山 | Medical capsule for treating cerebroma and its preparing process |
Non-Patent Citations (1)
| Title |
|---|
| 李洁等.垂体瘤61例临床诊治分析.《中国实用内科杂志》.2006,第26卷(第22期),1822-1823. * |
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