CN101006465A - System and method for linking VOIS across timepoints for analysis of disease progression or response to therapy - Google Patents
System and method for linking VOIS across timepoints for analysis of disease progression or response to therapy Download PDFInfo
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Abstract
A system and method for linking volumes of interest (VOIs) across timepoints are provided. The method comprises: loading an image dataset of a first timepoint and an image dataset of a second timepoint (210); registering the image dataset of the first timepoint and the image dataset of the second timepoint (220); displaying the image dataset of the first timepoint and the image dataset of the second timepoint (230); selecting a VOI in the image dataset of the first timepoint and the image dataset of the second timepoint (240); and linking the VOIs in the image dataset of the first timepoint and the image dataset of the second timepoint (250).
Description
The cross reference of related application
The application requires the U.S. Provisional Application No.60/581 that submitted on June 18th, 2004,136 right of priority, and its full content is by with reference to being incorporated herein.
Background of invention
1. technical field
The present invention relates to medical image analysis, and particularly relate to across time point and link interested volume (VOI) with analysis of disease progression or to the system and method for response of treatment.
2. the discussion of correlation technique
Using the functional imaging of single photon emission computed tomography (SPECT) and PET (positron emission tomography) (PET) is very valuable in the diagnosis of various medical science obstacles.Yet the uncertainty aspect the anatomy definition on SPECT and PET image has limited their effectiveness sometimes.In order to address this problem, sometimes magnetic resonance image (MRI) (MRI) and X-ray computer tomo photography (CT) image are combined with the function SPECT or the PET image of health the same area.This provides for research, diagnosis and the anatomy (MRI or CT) and physiology (SPECT or the PET) information of very important complementation treating.
Functive image and structural images are two types the medical images that the working doctor is used to diagnose the certain medical obstacle.For example those functive images that derive from SPECT or PET scanning provide physiological information, and for example those structural images that derive from CT or MRI provide the internal anatomy of health.Different medical imaging technologies can provide has complementation and the scanning of afoul information once in a while.For example, the use picture is filed and communication system (PACS) combines this image, and (via image co-registration or image registration) often may cause the additional clinical information in the image of this separation not obvious.Thereby, by on one group of function image, applying structure anatomy framework, in function image afterwards, can determine the position of tumour or other pathology, even the anatomical details here and inadequate.
Although utilize the structure of the compound overlapping medical image of image registration to be mainly used in the fusion of function and anatomical images, it also is applied in the image of series of identical pattern.This example is, in check subsequently, and the perhaps registration of the SPECT image of the same person under inspection in image that will have normal picked-up characteristic and unusual image comparison under a cloud.In addition, the registration of the image registration of SPECT and PET image and SPECT and PET image and anatomical atlas provides important means for the characteristic of relatively absorbing of assessment SPECT and PET radiopharmaceutical agent, and is associated with anatomy important means is provided for absorbing characteristic.
Multimode medical figure registration becomes just rapidly can provided remarkable help and improve the visualization tools of offering help aspect the diagnostic accuracy aspect the early detection of tumour and other disease.For example, even the radiology expert obtains for example help of the structural information of CT and MRI, also through being everlasting location and accurately discern on the cancerous tissue and meet difficulty, because the contrast between cancer and the surrounding tissue is very low in CT and MRI image.Yet,, might obtain the high-contrast image of antibody concentration in the tumour by using SPECT and radiolabeled monoclonal antibody.
Therefore, more and more wish the output and the strength of multiple medical image system are combined.Yet, owing to combination, its transmission of different file structures with knot and the registration and the video picture reason of composograph, also have some shortcoming.For example, this system does not support the combination of much more slightly data sets from different mode usually.In addition, many systems do not provide the quick and accurate means that change in the tumour of analyzing.In addition, many systems do not provide the rapid technology of aiming at from the medical image of different time points.For example, in order accurately to analyze the variation in the tumour, often need the image of contrast in the same pattern of different time spot scan.
Therefore, need a kind of technology, it can make the working doctor contrast and use patient scan identical or that different mode is obtained at different time, thereby the working doctor can make the more well-informed diagnosis of information, treatment and decision subsequently with low-cost and efficient way.
Summary of the invention
The present invention links interested volume (VOI) across time point and has solved occur in the prior art aforesaid and other problem with analysis of disease progression or to the system and method for response of treatment by providing.
In an embodiment of the invention, the method that links interested volume (VOI) across time point comprises: load the image data set of very first time point and the image data set of second time point; The image data set that registration should be put the very first time and the image data set of this second time point; Show the image data set of this very first time point and the image data set of this second time point; Concentrate selection VOI at the image data set of this very first time point and the view data of this second time point; And the VOI that concentrates of the view data that is linked at the image data set of this point and this second time point very first time.
Each all comprises the data of a kind of middle collection from computer tomography (CT), PET (positron emission tomography) (PET), single photon emission computed tomography (SPECT), magnetic resonance (MR) and ultrasound mode the image data set of this very first time point and the image data set of this second time point.
Each all comprises a kind of in the combination of combination, MR and SPECT image sequence of combination, CT and SPECT image sequence of combination, MR and PET image sequence of CT image sequence and MR image sequence, PET image sequence and SPECT image sequence, CT and PET image sequence and the ultrasonic image sequence image data set of this point and the image data set of this second time point very first time.
Each all comprises the image sequence that the image data set of this very first time point and the view data of this second time point are concentrated from a kind of data before the treatment, in the treatment neutralization treatment back check.Use a kind of in autoregistration, terrestrial reference registration and the vision registration that this first image data set and this second image data set are carried out registration.
This VOI is selected by the user.This VOI is a kind of in pathology, knurl and the cancer district.The image data set that shows the image data set of this point and this second time point for contrast very first time.
This method further comprises and quantizes this VOI, and wherein quantizing is a kind of in minimum deflection, maximum deviation, standard deviation, mean value, volume, average, diameter, area, number of picture elements and the barycenter.
In another embodiment of the present invention, the method that links interested volume (VOI) across time point comprises: load the image data set of very first time point and the image data set of second time point; The image data set that registration should be put the very first time and the image data set of this second time point; Show the image data set of this very first time point and the image data set of this second time point; Concentrate selection VOI in the view data of this very first time point; This VOI is copied to the image data set of this second time point from the image data set of this very first time point; And this VOI of concentrating of the view data that links the image data set of this point and this second time point very first time.
Each all comprises the data of a kind of middle collection from computer tomography (CT), PET (positron emission tomography) (PET), single photon emission computed tomography (SPECT), magnetic resonance (MR) and ultrasound mode the image data set of this very first time point and the image data set of this second time point.
Each all comprises a kind of in the combination of combination, MR and SPECT image sequence of combination, CT and SPECT image sequence of combination, MR and PET image sequence of CT image sequence and MR image sequence, PET image sequence and SPECT image sequence, CT and PET image sequence and the ultrasonic image sequence image data set of this point and the image data set of this second time point very first time.
Each all comprises the image sequence that the image data set of this very first time point and the view data of this second time point are concentrated from a kind of data before the treatment, in the treatment neutralization treatment back check.
This VOI is selected by the user.This VOI is a kind of in pathology, knurl and the cancer district.This method further comprises the variation that quantizes among this VOI and the detection VOI.
In another embodiment of the present invention, the system that links interested volume (VOI) across time point comprises: be used for stored program memory storage; With the processor of this memory storage communication, and this processor is by this procedure operation, with: load the image data set of very first time point and the image data set of second time point; The image data set that registration should be put the very first time and the image data set of this second time point; Show the image data set of this very first time point and the image data set of this second time point; Concentrate identification VOI at the image data set of this very first time point and the view data of this second time point; And this VOI of concentrating of the view data that links the image data set of this point and this second time point very first time.
Each all comprises the data of a kind of middle collection from computer tomography (CT), PET (positron emission tomography) (PET), single photon emission computed tomography (SPECT), magnetic resonance (MR) and ultrasound mode the image data set of this very first time point and the image data set of this second time point.
In one embodiment of the present invention, the system that links interested volume (VOI) across time point comprises: be used for stored program memory storage; With the processor of this memory storage communication, and this processor is by this procedure operation, with: load the image data set of very first time point and the image data set of second time point; The image data set that registration should be put the very first time and the image data set of this second time point; Show the image data set of this very first time point and the image data set of this second time point; Concentrate identification VOI in the view data of this very first time point; This VOI is copied to the image data set of this second time point from the image data set of this very first time point; And this VOI of concentrating of the view data that links the image data set of this point and this second time point very first time, wherein, the image data set of the image data set of this point and this second time point very first time each all comprise the data of gathering among a kind of from computer tomography (CT), PET (positron emission tomography) (PET), single photon emission computed tomography (SPECT), magnetic resonance (MR) and ultrasound mode.
Aforementioned feature is representative embodiments and is presented out to help understanding the present invention.Should be appreciated that it does not plan to be considered to by claim definition or the restriction of the present invention that limited by the claim equivalent.Therefore, the concise and to the point description of this feature should not be in and determines to be considered to conclusive in the equivalent.Further feature of the present invention will embody from accompanying drawing and accessory rights requirement in the following description.
The accompanying drawing summary
Fig. 1 be according to the present invention representative embodiments link the block scheme of the system of interested volume (VOI) across time point;
Fig. 2 is the flow process across the method for time point link VOI that according to the present invention representative embodiments is shown;
Fig. 3 is the patient's browser that is used to select the time point that will be loaded of the representative embodiments according to the present invention;
Fig. 4 is the chart that the level that is used for generation time point (hierarchy) of the representative embodiments according to the present invention is shown;
Fig. 5 is the sequence list dialog box of the effective and invalid image sequence of the demonstration of the representative embodiments according to the present invention time point that will be loaded;
What Fig. 6 A and 6B illustrated is the user interface of the representative embodiments according to the present invention;
Fig. 7 is the flow process across the method for time point link VOI that according to the present invention another representative embodiments is shown;
Fig. 8 is the equivalent outline line of the VOI on the viewing area of the user interface of representative embodiments according to the present invention; And
Fig. 9 is that the free contour of the cartouche on the viewing area of use user interface of the representative embodiments according to the present invention is described.
The detailed description of representative embodiments
Representative embodiments of the present invention relate to permission to two or more the multi-mode that compares each other of multiple testing use.This is undertaken by the scanning subsequently after initial diagnosis and the treatment is compared usually.For example, the present invention can be used for the oncology situation, wherein carries out one or more and checks subsequently with assess disease progress and the response to treating.The present invention can also be used for following medical model, and wherein change-detection can be used to detect pathology, tumour, cancer, etc.
For example, the present invention can be used for following medical imaging field: carry out change-detection in time by the tomography that uses a computer (CT) or magnetic resonance (MR) image-PET (positron emission tomography) (PET) or CT-single photon emission computerized tomography (SPECT) and monitor response to treatment; Cut apart with lesion detection and detect osteocarcinoma by carrying out bone; Use perfusion and spectroscopy to detect liver cancer; Detect breast cancer and identify optimum or malignant tumour in conjunction with perfusion and spectroscopy; And by use semi-automatic and automated tool to measure neurology as the brain structural volume of hippocampus volume.
The pattern that the present invention uses is that for example: static decay is proofreaied and correct (AC) PET, static undamped correction (NAC) PET and respiration gate control PET; Static AC SPECT or nuclear medicine (NM) and static NAC SPECT or NM; High-resolution ct, low resolution CT, spiral CT and respiration gate control CT; High resolving power magnetic resonance (MR); And it is ultrasonic.The present invention can load the data set that is called as stand.In addition, the present invention can accept to comprise the image sequence of the section that does not wait at interval or comprise the image sequence of overlapping section.
The present invention can further load static AC PET or the static NAC PET data set that the CT data set with corresponding registration is fused to, this CT data set is from patient's check, via the PET/CT scanner or gather on the equipment that separates.In addition, can also load static AC SPECT or static NAC SPECT data set that the CT data set with corresponding registration is fused to, this CT data set is from patient's check, via the SPECT/CT scanner or gather on the equipment that separates.In addition, can load and be presented at the sequence of two model identical types that merge in the single time point.For example, the present invention can allow CT data set and another CT data set to merge, and wherein these two data sets are via identical CT scan device or distinct device collection.
Fig. 1 be according to the present invention representative embodiments across time point link volume of interest (VOI) with analysis of disease progression or to the block scheme of the system 100 of the response of treatment.
As shown in Figure 1, system 100 especially comprises: a plurality of scanning device 105a, and b ..., x, computing machine 100 and be connected to operator's control desk 115 on the network 120.Scanning device 105a, b ..., each of x can be a kind of in following: the MR imaging device, the CT imaging device, spiral CT equipment, PET equipment, SPECT equipment, hybrid PET-CT equipment mixes SPECT-CT equipment, two dimension (2D) or three-dimensional (3D) fluoroscopic image equipment, 2D, 3D or the four-dimension (4D) supersonic imaging apparatus, perhaps x-ray equipment.Except aforementioned scanning device, scanning device 105a, b, ..., among the x one or all can be the equipment of multi-mode or mixed sweep, and it can for example scan in PET pattern, SPECT pattern or the MR pattern, perhaps produces PET and CT scan from single mixing apparatus.
The operation of system 100 is by operator's control desk 115 control, and it comprises controller 165, for example keyboard and such as the display 160 of CRT monitor.Operator's control desk 115 and computing machine 110 and scanning device 105 communications, thus by scanning device 105a, b ..., the 2D view data that x collects can be depicted as the 3D data and observation on display 160 by computing machine 110.Should be appreciated that computing machine 110 can constitute when lacking operator's control desk 115, use for example import 150 and output 155 equipment move the particular task of carrying out by controller 165 and display 160, thereby operation and demonstration are by scanning device 105a, b ..., the information that x provides.
Operator's control desk 115 comprises that further the Digital Image Data of the image data set (a perhaps part wherein) that can handle collection is to produce and to show any suitable image drawing system/tool/application of 2D and/or 3D rendering on display 160.More particularly, image drawing system can be the application of a kind of 2D/3D of providing drafting and medical image video picture, and it moves on general or special purpose computer workstation.Computing machine 110 can comprise that also the Digital Image Data of the image data set that is used to handle collection is to produce and to show the image drawing system/tool/application of 2D and/or 3D rendering.
As shown in Figure 1, VOI link module 145 can also be used for receiving and handling digital medical image data by computing machine 110, as mentioned above, it with untreated view data form, 2D data reconstruction (for example can be, axial slices) or such as the 3D data reconstruction of volumetric image data or many planar reformat, the perhaps combination of any this form.Data processed result can be drawn with 2D and/or the 3D that produces view data according to this data processed result via the image drawing system that network 120 outputs to operator's control desk 115 from computing machine 110, as cutting apart of organ or anatomical structure, color or Strength Changes, or the like.
Fig. 2 is the process flow diagram across the method for time point link VOI that according to the present invention representative embodiments is shown.As shown in Figure 2, the user loads a plurality of time points via patient's browser 300 of Fig. 3 (210).This finishes by the image data set of selecting very first time point.The image data set of this very first time point comprises one of following combination of image sequence: single CT sequence; Single PET sequence; Single SPECT sequence; From same check or the CT of different checks and the combination of PET sequence; From same check or the CT of different checks and the combination of SPECT sequence.The representative data collection combination of single time point is listed as following table 1:
Table 1
| The data set of single time point or combination |
| Single CT sequence |
| Single PET-AC sequence |
| Single PET-NAC sequence |
| Single SPECT-AC sequence |
| Single SPECT-NAC sequence |
| CT sequence+PET-AC sequence |
| CT sequence+PET-NAC sequence |
| CT sequence+SPECT-AC sequence |
| CT sequence+SPECT-NAC sequence |
| Single MR sequence |
| MR sequence+PET-AC sequence |
| MR sequence+PET-NAC sequence |
| MR sequence+SPECT-AC sequence |
| MR sequence+SPECT-NAC sequence |
Very first time point and subsequently the image data set of time point can be from before the treatment, in the therapeutic process or the check after the treatment.In addition, this some very first time and subsequently time point can comprise same image sequence in the two as sequence.For example, in the sample patient level that Fig. 4 describes, high-resolution ct sequence and PET AC sequence can be combined with formation very first time point, and this high-resolution ct sequence and PET NAC sequence can be combined to form second time point.In other words, single time point all has contribution to first and second time points.
After having selected the image data set that to put the very first time, load this image data set.Image data set can load by following manner: pull the image data set of this selection to the viewing area from patient's browser 300; Click the expansion button on patient's browser 300 and double-click related data on patient's browser 300.For example, the user can in patient's browser 300, carry out relevant select and button click to load.The grade that data are selected in patient's browser 300 can be with sequence, verify as grade, perhaps is grade with patient.
Also can load and comprise not the image sequence of section or overlapping section equidistantly.In addition, can also load multiple image and dissimilar NM images, as NM RECON TOMO (for example, in single image as the volume of a plurality of frames).Further, can load the Spiral CT scan data.In case loaded this data, used image header information to verify.Thus, when the check of having selected single different patient's heading messages with comprising of a plurality of time points when being used to load, can eject the alarm dialogue indicating the difference of patient ID to the user, and indication is used for the correct method of load image sequence thus.The alarm dialogue can also be used to point out user's modification this patient ID.After data are verified, according to this sequence construct volume.
In case loaded the image data set that to put the very first time, the image data set of second time point selected.The image data set of second time point can similarly be selected with the image data set of very first time point.In addition, this second time point can be in the above-mentioned image sequence of very first time point one.After having selected second time point that will load, it is loaded.Equally, be used for loading a kind of second time point that loads of the above-mentioned technology of very first time point.
When loading this second time point, whether the combination that is identified for many time points loaded data collection effectively and then classifies.Be used for effectively being combined in shown in the following table 2 of many time points loaded data collection:
Table 2
| Very first time point | Second time point |
| PET AC separately or have a NAC | PET AC separately or have a NAC |
| PET AC separately or have a NAC+CT | |
| PET AC separately or have a NAC+MR | |
| SPECT | |
| SPECT AC separately or have a NAC | SPECT AC separately or have a NAC |
| SPECT AC separately or have a NAC+CT | |
| SPECT AC separately or have a NAC+MR | |
| PET | |
| CT | CT |
| CT+PET AC separately or have a NAC | |
| CT+SPECT AC separately or have a NAC | |
| MR | |
| MR | MR |
| MR+PET AC separately or have a NAC | |
| MR+SPECT AC separately or have a NAC | |
| CT | |
| PET AC separately or have a NAC+CT | PET AC separately or have a NAC |
| CT | |
| PET AC separately or have a NAC+CT | |
| MR | |
| SPECT | |
| SPECT AC separately or have a NAC+CT | SPECT AC separately or have a NAC |
| CT | |
| SPECT AC separately or have a NAC+CT | |
| MR | |
| PET |
As shown in table 2, for example, if the very first time that has loaded point comprises that SPECT AC data set is independent or has the NAC data set, then can load SPECT NAC data set from this point, SPECT AC data set separately or have NAC data set and SPECT AC data set separately or have among NAC data set and the CT any one, and the CT data set can be loaded as second time point very first time.Yet if second time point is not one of effective combination that is used for by the loaded data collection, effective combination of loaded data collection is pointed out to be used in sequence dialogue 500 that so can displayed map 5 to the user.
As further illustrating in the table 2, PET or SPECT AC and NAC data set are not separately listed, because suppose whenever the user selects PET AC data set and loading, and PET AC data set all will be shown.Similarly, when the user selects PET NAC data and loads, this PET NAC data set will be loaded also and the CT data set is shown together.Therefore the user can switch between PET AC and PET NAC data set.Identical functions is effective too to SPECT AC/NAC data set.
After the image data set of first and second time points is loaded, it is carried out registration (220).Registration is the process of aiming at medical image.In other words, it is the process that two input image sequences that produced at different time by different mode or same pattern are aimed at.In registration process, one of data centralization will be fixed to for example constant position, and another data set will be converted, and for example conversion, rotation or change ratio are with two data set pair standards.Fixing data set can also be called as reference volume, and the data set that will be converted can also be called as the model volume.Therefore, this model volume being carried out geometry deformation is complementary with the anatomy with reference volume.
In step 220, can use multiple method for registering/algorithm.It can be, for example: and automatically/interactive information registration (for example, autoregistration); Terrestrial reference registration and vision alignment (for example, artificial coupling).
Automatically aim at the full automatic matching algorithm that is based on interactive information or standardized interactive information.Yet before the initialization autoregistration, the user can carry out vision alignment to improve the performance of autoregistration.Registration is carried out when can also load a plurality of time points in step 210.
Autoregistration comprises the following steps: first image sequence and the second image sequence registration with first image data set of very first time point; The first image sequence registration of first image sequence of first image data set that will put the very first time and second image data set of second time point; And with the second image sequence registration of second image data set of first image sequence of second image data set of second time point and second time point.
For example, when having loaded two CT-PET scannings, the registration of CT-PET scanning all begins first and second time points successively.In case this CT-PET registration is finished, start registration these two CT checks are complementary across this first and second time point.When autoregistration carries out, in alpha blended image (for example, fused images), can show the process of this registration.Can also the show process text to indicate the current process of this autoregistration.
The terrestrial reference registration is the known mark of consistent location recognition in two image sequences.Algorithm calculates registration from this identification.On fused data set, carry out vision alignment.Here, reference sequences is still fixing and use for example vision alignment control, can conversion/rotating model sequence to aim at this reference picture.
At registration after the data set of this first and second time point, can show it (230).It may be displayed on the viewing area 610 of user interface 600 among Fig. 6 A for example.Should be appreciated that each image data set of first and second time points can be shown when in a single day it be loaded.In addition, the image data set of first and second time points can be shown when it just is registered.
In case demonstrate the image data set of this first and second time point, the user can be then at each time point VOI (240) that draws.This can realize by tools area 640 selection tools of the profile panel 630 of user from the control area 620 of user interface 600.This instrument can for example be the free equivalence-tool contour that produces the Ellipse tool of oval object or produce the equivalent object.This instrument can be used for then around for example pathology in the image that viewing area 610 the shows border of drawing.By adopting 2D profile that draws around pathology and the irregular entity of 3D that converts thereof into the pathology in this volume of expression to form VOI.The VOI of this 3D is used to show the profile of VOI.
After each time point has all drawn VOI, time point is linked (250).The following link of time point: duplicate profile from a time point automatically to another, perhaps select specific profile and button click to come to duplicate selected profile to another from a time point by the user.In case because registration image data set, just can utilize the effective registering result, thereby link VOL.In addition, when duplicating profile, determine the target voxel coordinate by using distortion, registration results is used in this distortion.As above the effective combination that is used for a plurality of time point loaded data collection shown in the table 2 also is used for across time point link VOI.In case linked this VOI across time point, the working doctor can use it for and for example follow the trail of the lesion size variation, perhaps produces comparative information.
In interchangeable link embodiment, the user can carry out Intelligence Selection and select option to be linked to another time point then on VOI in second time point.Subsequently, the user can carry out Intelligence Selection and select option to accept this link on VOI in very first time point.These two VOI will be linked then.Because image data set is registered,, then can provide warning information to surpass the threshold value of spatial diversity with indication if the user attempts this VOI of link in the spatially inconsistent position.Should be appreciated that the VOI of link can untie link by the button about removing link on the control area 620 of selecting user interface 600 simply.
On the user interface 600 of Fig. 6 A and 6B, show embodiment across time point link VOI.As shown in Figure 6A, viewing area 610 is divided into a plurality of zones, for example, and first or transverse axis viewing area 610a; Crown viewing area 610b; The viewing area 610d of second or transverse axis viewing area 610c and fusion.First viewing area 610a comprises the image 650 with the image co-registration drafting of CT and PET data, and it comprises two potential canceration 650a and 650b.Around potential canceration 650a and 650b is two annular boundary 660a and 660b.These two annular boundary 660a and 660b are the VOI that the user uses the instrument from the tools area 640 of profile panel 630 to draw.
As among Fig. 6 A further shown in, second viewing area 650c illustrates image 670, it comprises two potential canceration 680a and the 680b that is centered on by two annular boundary 690a and 690b.Image 670 is images with the drafting of the image co-registration shown in the image 650 of CT and PET data, just from another time point.Refer back to first viewing area 610a, the user is in the processing that these two annular boundaries or VOI 660a and 660b are linked with annular boundary or VOI 690a and 690b.This instrument by using control area 620 is to select two VOI 660a and 660b and link two VOI690a and 690b finishes.In case two VOI 660a that selected to be used for linking with two VOI 690a and 690b and 660b, user can accept the link that shows among second viewing area 610c as Fig. 6 B.
Fig. 7 is the process flow diagram across the method for time point link VOI that according to the present invention another representative embodiments is shown.As shown in Figure 7, load a plurality of time points (710).Time point such as toply load as described in reference to step 210 among the figure 2.Subsequently, time point is carried out registration (720) and shows (730) then.These steps also can be carried out according to the step 220 and 230 of Fig. 2.After the image about the time point that loads is shown, the user VOI (740) that can in of time point, draw.This can finish from tools area 640 selection tools of user interface 600 and the pathology around the image that for example shows the border of drawing by the user.
Illustrated among Fig. 8 on 3 * 3 spaces of a whole page of viewing area 800 and to have used equivalent outline line and around the draw embodiment of VOI of pathology.Particularly, Fig. 8 illustrates the equivalent outline object of describing with the image and the fused images of different mode.When the user drew VOI on PET image for example, this VOI was copied on the CT image that is positioned at suitable voxel coordinate place automatically, and this suitable voxel coordinate obtains by utilizing distortion, and the registration results between PET and the CT image is used in this distortion.In addition, VOI can show on fused images.Except the oval or free equivalent tool contour of discussing with reference to the step 240 of figure 2 above using, the user can also use free VOI instrument around the manual border of drawing of pathology.The example that uses the freewheel profile of cartouche on 2 * 2 spaces of a whole page of viewing area 900 has been shown among Fig. 9.
The VOI in case drawn in of time point, user can copy to this VOI another time point (750) then.This selects VOI by the user and clicks in the tools area 640 of user interface 600 and finish to the button of another time point about the VOI that duplicates selection.For example, the user can select the VOI in the very first time point and click this reproduction button.The VOI of this selection is copied on second time point that is in suitable voxel coordinate place then.Should be appreciated that this voxel coordinate is consistent, because the hypothesis image data set is at this registration.In case duplicated these VOI, these VOI use the technology AutoLink of describing as in the step 250 of top Fig. 2 (760).
Should be appreciated that in step 750, the VOI or the profile that are drawn by the user can copy to next or previous image slices.This will duplicate the profile that this draws on the identical 2D point of the next or previous section of current slice.Can also use the passing instrument of the tools area 630 of user interface 600 that this profile that duplicates is passed suitably to be tied to the pathology point.Be also to be understood that in step 750 all VOI can be from a point in time copy to another time point.For example, the user can come the select time point by the time point icon in the control area 620 of clicking user interface 600.The user can click reproduction button then.This will make at them voxel coordinate place in each comfortable very first time point duplicate all VOI in the very first time point.To link these VOI then.
After having linked these VOI, can follow the tracks of the variation and the generation of relative comparative information across time point.For example, can calculate the ratio of mean value between these two VOI.In addition, can calculate for the pathology of background or for the pathology of reference ratio.These VOI can also be quantized.For example, when quantizing these VOI, the user can be chosen in any VOI of mark on the pathology to know relative particular quantization parameter.Quantization parameter can be minimum value, maximal value, standard deviation, mean value, volume and the average of VOI.
Should be appreciated that,, can also link various operations according to the present invention except the VOI in the viewing area is linked with cutting apart.For example, can link zoom and sweep operation, can change and rolling across the orientation of time point link by image slices across time point.In addition, can link synchronous observation, shielding and married operation between the various planes of delineation across time point.
According to a representative embodiments of the present invention, the working doctor can contrast the patient scan from two different time points (for example, before the treatment and after the treatment) effectively.By autoregistration with show the PET/CT or the SPECT-CT image of the check that comfortable different time points gathers, the present invention doctor that helps to obtain employment to make the more well-informed diagnosis of information, treatment and decision subsequently.For example, the invention provides the demonstration of CT image that merge with function PET or SPECT data set, the volume drafting.Its also feasible VOI that can draw, these VOI calculate the standard uptake value (SUV) in pathologies.In addition, VOI can be copied on the suitable voxel coordinate of comparison test from a check.
Be also to be understood that because some that describe in the accompanying drawing are formed system components and method step can be realized with software the mode that the actual annexation between this system component (perhaps this treatment step) can be programmed according to the present invention and different.Those of ordinary skills can finish these and similar realization or structure of the present invention after knowing the present invention's instruction given here.
Be also to be understood that above-mentioned explanation only is the representative of the embodiment that illustrates.For convenience of the reader, above-mentioned explanation concentrates on the representative example of possible embodiment, and the example the principles of the invention is shown.This instructions does not attempt to itemize all possible variation.Interchangeable embodiment may not appear at detailed description part of the present invention, does not perhaps further describe and can utilize alternative to a part, should not be considered as not require these to replace embodiment.Under the situation that does not deviate from the spirit and scope of the present invention, can realize other application and embodiment.
Because foregoing and comprise that the enforcement that the non-creativeness of foregoing substitutes can produce many conversion and combination, so the present invention do not plan to be limited to the embodiment of detailed description, but about following claim the present invention limited.Should be appreciated that many this embodiments that do not have to describe drop in the literal scope of following claim, and other be equal to.
Claims (20)
1, a kind ofly link the method for interested volume (VOI), comprising across time point:
Load the image data set of very first time point and the image data set of second time point;
The image data set that registration should be put the very first time and the image data set of this second time point;
Show the image data set of this very first time point and the image data set of this second time point;
Concentrate selection VOI at the image data set of this very first time point and the view data of this second time point; And
Be linked at the image data set of this very first time point and the concentrated VOI of view data of this second time point.
2, the method for claim 1, wherein, the image data set of the image data set of this point and this second time point very first time each all comprise the data of gathering among a kind of from computer tomography (CT), PET (positron emission tomography) (PET), single photon emission computed tomography (SPECT), magnetic resonance (MR) and ultrasound mode.
3, method as claimed in claim 2, wherein, the image data set of the image data set of this point and this second time point very first time each all comprise a kind of in the combination of combination, MR and SPECT image sequence of combination, CT and SPECT image sequence of combination, MR and PET image sequence of CT image sequence and MR image sequence, PET image sequence and SPECT image sequence, CT and PET image sequence and the ultrasonic image sequence.
4, method as claimed in claim 3, wherein, each all comprises the image sequence that the image data set of this very first time point and the view data of this second time point are concentrated from a kind of data before the treatment, in the treatment neutralization treatment back check.
5, the method for claim 1, wherein use a kind of in autoregistration, terrestrial reference registration and the vision registration that this first image data set and this second image data set are carried out registration.
6, the method for claim 1, wherein this VOI is selected by the user.
7, the method for claim 1, wherein this VOI is a kind of in pathology, knurl and the cancer district.
8, show that the method for claim 1, wherein the image data set of the image data set of this point and this second time point for contrast very first time.
9, the method for claim 1, wherein further comprise:
Quantize this VOI, wherein quantizing is a kind of in minimum deflection, maximum deviation, standard deviation, mean value, volume, average, diameter, area, number of picture elements and the barycenter.
10, a kind ofly link the method for interested volume (VOI), comprising across time point:
Load the image data set of very first time point and the image data set of second time point;
The image data set that registration should be put the very first time and the image data set of this second time point;
Show the image data set of this very first time point and the image data set of this second time point;
Concentrate selection VOI in the view data of this very first time point;
This VOI is copied to the image data set of this second time point from the image data set of this very first time point; And
Link the image data set of this very first time point and this concentrated VOI of view data of this second time point.
11, method as claimed in claim 10, wherein, the image data set of the image data set of this point and this second time point very first time each all comprise the data of gathering among a kind of from computer tomography (CT), PET (positron emission tomography) (PET), single photon emission computed tomography (SPECT), magnetic resonance (MR) and ultrasound mode.
12, method as claimed in claim 11, wherein, the image data set of the image data set of this point and this second time point very first time each all comprise a kind of in the combination of combination, MR and SPECT image sequence of combination, CT and SPECT image sequence of combination, MR and PET image sequence of CT image sequence and MR image sequence, PET image sequence and SPECT image sequence, CT and PET image sequence and the ultrasonic image sequence.
13, method as claimed in claim 12, wherein, the image sequence that the image data set of this very first time point and the view data of this second time point are concentrated comprises from a kind of data before the treatment, in the treatment neutralization treatment back check.
14, method as claimed in claim 10, wherein, this VOI is selected by the user.
15, method as claimed in claim 10, wherein, this VOI is a kind of in pathology, knurl and the cancer district.
16, method as claimed in claim 10 wherein further comprises:
Quantize this VOI.
17, method as claimed in claim 16 wherein further comprises:
Detect the variation among the VOI.
18, a kind ofly link the system of interested volume (VOI), comprising across time point:
Be used for stored program memory storage;
With the processor of this memory storage communication, and this processor is by this procedure operation, with:
Load the image data set of very first time point and the image data set of second time point;
The image data set that registration should be put the very first time and the image data set of this second time point;
Show the image data set of this very first time point and the image data set of this second time point;
Concentrate identification VOI at the image data set of this very first time point and the view data of this second time point; And
Link the image data set of this very first time point and this concentrated VOI of view data of this second time point.
19, system as claimed in claim 18, wherein, the image data set of the image data set of this point and this second time point very first time each all comprise the data of gathering among a kind of from computer tomography (CT), PET (positron emission tomography) (PET), single photon emission computed tomography (SPECT), magnetic resonance (MR) and ultrasound mode.
20, a kind ofly link the system of interested volume (VOI), comprising across time point:
Be used for stored program memory storage;
With the processor of this memory storage communication, and this processor is by this procedure operation, with:
Load the image data set of very first time point and the image data set of second time point;
The image data set that registration should be put the very first time and the image data set of this second time point;
Show the image data set of this very first time point and the image data set of this second time point;
Concentrate identification VOI in the view data of this very first time point;
This VOI is copied to the image data set of this second time point from the image data set of this very first time point; And
Link the image data set of this very first time point and this concentrated VOI of view data of this second time point, wherein, the image data set of the image data set of this point and this second time point very first time each all comprise the data of gathering among a kind of from computer tomography (CT), PET (positron emission tomography) (PET), single photon emission computed tomography (SPECT), magnetic resonance (MR) and ultrasound mode.
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| US11/146,966 US8160314B2 (en) | 2004-06-18 | 2005-06-07 | System and method for linking VOIs across timepoints for analysis of disease progression or response to therapy |
| PCT/US2005/020865 WO2006009675A2 (en) | 2004-06-18 | 2005-06-13 | System and method for linking vois across timepoints for analysis of disease progression or response to therapy |
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| CNA2005800286883A Pending CN101010696A (en) | 2004-06-18 | 2005-06-15 | System and method for monitoring disease progression or response to therapy using multi-modal visualization |
| CNA2005800278618A Pending CN101019152A (en) | 2004-06-18 | 2005-06-15 | System and method for loading timepoints for analysis of disease progression or response to therapy |
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Also Published As
| Publication number | Publication date |
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| CN101010696A (en) | 2007-08-01 |
| CN101019152A (en) | 2007-08-15 |
| CN101006465B (en) | 2013-03-20 |
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