CN100998888A - Antimicrobe composition and vulnus coverage - Google Patents
Antimicrobe composition and vulnus coverage Download PDFInfo
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- CN100998888A CN100998888A CN 200610152642 CN200610152642A CN100998888A CN 100998888 A CN100998888 A CN 100998888A CN 200610152642 CN200610152642 CN 200610152642 CN 200610152642 A CN200610152642 A CN 200610152642A CN 100998888 A CN100998888 A CN 100998888A
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Abstract
An antimicrobial composition and its wound covering material are disclosed. Said wound covering material is composed of a carbon material in the form of powder, particles, fibers and/or flakes and chosen from activated carbon, graphite, carbon and their composition, a noble metal chosen from Ag, Au, Pd, Pt, Cu, Zn and their composition, and flexible substrate.
Description
Technical field
The precious metal that the present invention relates to carry with carbonaceous material is in the use of antimicrobial compositions and antimicrobial wound covering thing.The invention particularly relates to the antimicrobial compositions and the wound covering thing that contain with the precious metal of activated carbon or the carrying of porous graphite, in the mode of making an initiative sally, assemble and and then destroy microorganism near said composition and wound covering thing, thereby prevent said composition or wound covering thing with and the subject matter of being used be subjected to infected by microbes.
Background technology
Evolution along with science and technology; processing for health wound position; except looking different wound type in affected part directly is coated with the microbicidel medicine; also carry out gradually at present with as medical adhesive tape, patch, glued membrane binder, the OK medical wound covering thing such as patch that stretches tight add in a covered manner, to isolate wound and extraneous improperly to contact, protect wound, prevent wound infection and minimizing pain or the like.
Known as precious metals such as silver, gold, palladium, platinum, copper and zinc have the microbicidel benefit, and above-mentioned these precious metals also show through many document Teaching-with in obducent use.Say it for example, give people's such as RobertEdward Burrell U.S. Pat 6,692,773B2, Teaching-with show with crystallite dimension not as good as 100 nanometers as precious metal (or its alloy or chemical compound) coated fabrics such as silver, gold, palladium, platinum, the covering as benefits such as anti-skin hyperplasias is provided.The U.S. Pat 5,782,788 of giving Widemire has disclosed fixedly native silver layer of gauze pad, to suppress antibacterial, virus or conk.Give the U.S. Pat 5 of Fabo, 340,363 disclose a kind of covering, it comprises outer absorbent layer and is woven with elastica and through the inside porous hydrophobic layer of soft, hydrophobic polysiloxanes or polyamine Ethyl formate gel institute encapsulate, and this gel can be used as releive material and stimulate wound to restore the carrier of reagent etc. of antibacterial agent (as zinc), pain.
Give people's such as Klippel U.S. Pat 3; 830; 908 Teaching-with show with the carrier of micronize allantoin as antibacterial or system bacterium composition (as the allantoin Itrol .); this combination is scattered in plastics system air clamping plate or other wrapping product surface, looks the separation situation of molecular moiety and antibacterial action is provided.Give people's such as McKnight U.S. Pat 3,800,792 disclose the covering that a kind of surgical operation is used, it has through rubbing the collagen foam thin film of skin, reorganization, this thin film is the thick pantostrat that is pressure bonded to inert polymer, this collagen layer contains the segmentation silver metal, and the interpolation of this segmentation silver metal is reached by this collagen film being dipped in Tollens reagent (Tollen ' s reagent).2,934,066 of U.S. Pat giving Stowasser provides a kind of covering, and its fiber by the absorbability washing is formed, as: through the aluminum coating and with compressed cellulose is the carding fur of backing, and the Fypro that is covered with vacuum-deposited silver.
By above-mentioned prior art as can be known, about the use of microbicidel precious metal in medical treatment, especially obducent use, still be conceived to the independent use of above-mentioned these precious metals so far, only relate at the most with the form of alloy or chemical compound and use above-mentioned these precious metals, all non-about use with the precious metal of carbonaceous material carrying.In addition,, only can eliminate this microorganism when touching precious metal, the passive microbicidel benefit of " passive type " only can be provided at the most in microorganism " just " though aforementioned known use can provide the microbicidel benefit.
In addition, known to the person of ordinary skill in the field, above-mentioned precious metal must be under the situation that has moisture content to exist, ability tool microbiocidal activity.Therefore, when reality is used, must confirm usually to contain moisture in the environment for use, in case of necessity, must add moisture content, so that aqueous environment to be provided.Say it for example, according to U.S. Pat 6,692,773B2 Teaching-with shows, when the nanometer precious metal being coated on the covering that uses for local skin, need keep this covering under aqueous conditions, the effect (walking to the 7th hurdle the 17th row) that can provide this precious metal to desire referring to this patent description content the 6th hurdle the 64th.Therefore, US6,692,773B2 Teaching-with shows, the preferable absorbed layer that comprises of its covering is to maintain moisture content, for the usefulness (referring to this patent description content the 5th hurdle the 33rd to 37 row) of this precious metal of activation.Aforementioned need have moisture to activate the demand of above-mentioned these precious metals, also can be with reference to as documents such as http://www.burnsurgery.org/Modules/silver/images/section7b/Mid_ partial_thickness3copy.jpg.
The precious metal that The present invention be directed to above-mentioned tool microbicidel benefit provides in another form of medical applications.In preferred implementation, especially the mode that can make an initiative sally is assembled also and then destroy microorganisms, effectively reduces even exempt infection by microorganisms.
Summary of the invention
In the present invention, unless stated otherwise, otherwise the carbonaceous material of being addressed includes powder, granule, fiber and different shape such as laminar.
One object of the present invention provides a kind of wound covering thing, and it comprises carbonaceous material, is carried on the precious metal of this carbonaceous material and the flexible substrate layer of optionally selecting for use.Wherein, this carbonaceous material is selected from following group: activated carbon, graphite, carbon and combination thereof, and this precious metal is selected from following group: silver, gold, palladium, platinum, copper, zinc and combination thereof.This covering can optionally contain other therapeutic activity composition in addition.
Another object of the present invention provides a kind of cover group, and it comprises wound covering thing of the present invention and retaining element.But this retaining element can be the instrument of this wound covering thing of any localized immobilization.Say it for example, can be adhesive tape, binder or patch.
Another purpose of the present invention, provide the antimicrobial compositions that a kind of confession is locally applied to skin, it comprises the precious metal that is carried on carbonaceous material, wherein this carbonaceous material is selected from following group: activated carbon, graphite, carbon and combination thereof, and this precious metal is selected from following group: silver, gold, palladium, platinum, copper, zinc and combination thereof.Said composition can optionally contain other therapeutic activity composition in addition.
Among the present invention, preferable employing activated carbon or porous graphite are as this carbonaceous material.In this, all know because effects such as the electrostatic attraction of microorganism and activated carbon/porous graphite surface or Van der Waals forces, and the bioaffinity of activated carbon/porous graphite, make microorganism to assemble and be adsorbed in activated carbon/porous graphite surface.Thereby, only can destroy, kill the negative effect of the microorganism that " just " and precious metal touch compares with prior art, the mode that a little modes of of the present invention can make an initiative sally, assemble and and then destroy, kill microorganism around the precious metal, relatively better microbicidel benefit is provided.In addition, adopt in the mode of activated carbon as carbonaceous material, the present invention also can additionally not add moisture content or adopt under the situation of other measure, the precious metal that activation is adopted.This promptly must additionally add moisture content with prior art and/or use as the water holding assembly of absorbed layer and compare with activation microbicidel precious metal, and easy means reaches the microbicidal benefit of institute's desire relatively.
Description of drawings
Fig. 1 is the embodiment sketch map of wound covering thing of the present invention, is depicted as patch.
Fig. 2 is the sketch map of another embodiment of wound covering thing of the present invention, is depicted as patch.
Fig. 3 is the sketch map of the another embodiment of wound covering thing of the present invention, is depicted as gauze.Fig. 3 A is the local amplification plan view of this gauze.
Fig. 4 is the sketch map of an embodiment again of wound covering thing of the present invention, is depicted as O.K. and stretches tight.
Fig. 5 is the sectional view along Fig. 4 line 5-5.
The main element description of symbols
1 patch
10 substrate layers
The first surface of 11,12 substrate layers 10 and second surface
20 antimicrobial layers
30 are loaded with the carbonaceous material of precious metal
40 protective layers
50 medicament layers
100 gauzes
110 substrate layers
The first surface of 111,112 substrate layers 110 and second surface
120 antimicrobial coatings
200 O.K. stretch tight
210 substrate layers
211,, the first surface of 212 substrate layers 210 and second surface
220 pressure-sensitive adhesive layer
230 antimicrobial layers
240 protective layers
The specific embodiment
Wound covering thing of the present invention comprises carbonaceous material, is carried on the precious metal of this carbonaceous material and the flexible substrate layer of optionally selecting for use, wherein, this flexible substrate layer has first surface and second surface, and this carbonaceous material that is loaded with precious metal is overlying at least a portion of this first surface.
The contained flexible substrate layer of wound covering thing of the present invention can be porous or medicament can not penetrating type.If desire to provide wound covering thing as gauze or binder, then should with porous, be preferably non-sticky stuff and constitute this flexible substrate.And, then should adopt the medicament can not the penetrating type base material if desire to provide wound covering thing as patch.General knownly can all can be used for the present invention in order to the wound covering thing to be provided and to meet aforementioned porous or the medicament material of penetrability not.Say it (but not as limit) for example, weaven goods (woven fabric) or non-woven fabric (non-wovenfabric) that can following one or more material constituted provide porous substrate: natural fiber, polyolefine fiber, polyester fiber, polyurethane fiber, Fypro, poly-cellulose fibre and cotton fiber etc. are preferably non-woven fabric.Can in order to provide medicament not the polymer of penetrable base material then comprise polrvinyl chloride, polyvinyl dichloride, polyolefin (as ethylene vinyl acetate copolymer, polyethylene and polypropylene), polyureas and polyester (as polyethylene terephthalate).This medicament can not can be single polymers layer or thin film by the penetrating type base material, or by pressing thing that multiple layer polymer constituted.
The contained carbonaceous material of wound covering thing of the present invention is selected from following group: activated carbon, graphite, carbon and combination thereof are preferably activated carbon or porous graphite.Say it (but not as limit) for example, can adopt activated carbon fiber, have granule or pulverous bamboo carbon (charcoal), as the porous graphite of soft graphite (flexible graphite) or expanded graphite (extended graphite) and/or by powder and/or granular activated carbon and/or the institute's pressing of porous graphite and thin slice.This precious metal is selected from following group: silver, gold, palladium, platinum, copper, zinc and combination thereof, and be preferably silver.
Can any suitable means, as soaking (immersing), thermal cracking (thermocracking), plating (electroplating), electroless plating (electroless plating) or vacuum evaporation modes such as (vacuumplating) precious metal is carried on the carbonaceous material, and this precious metal can any suitable form be carried on this carbonaceous material.Precious metal ion for more effective release tool microbiocidal activity, this precious metal is preferable to be carried on carbonaceous material with the particulate form with nano-scale, and the particle diameter of microgranule is no more than 200 nanometers, is more preferred to be no more than 100 nanometers, and is best for being no more than 50 nanometers.
Below will be to carry the preparation of silver-colored carbonaceous material, illustrate multiple can be in order to the carbonaceous material that carry precious metal of preparation for the present invention's use:
Method one:
A, immersion silver nitrate solution
Activated carbon fiber is soaked in silver nitrate solution lasts 1 to 720 minute under normal pressure or vacuum state, make silver be reduced to the activated carbon fiber surface, then carry out drying, to remove water.The pH value of may command silver nitrate solution and carries out this drying process under in 25 to 150 ℃ in the 3-8 scope.
B, Pintsch process
The high temperature furnace that places temperature to be controlled at 120 to 450 ℃ the argentiferous activated carbon fiber lasts 5 to 120 minutes, makes the silver on activated carbon fiber surface be cracked into superfine metallic particles.For avoiding carbon fiber oxidation or ashing, be preferably and carry out this Pintsch process operation in vacuum or under the situation that exists as protection of nitrogen gas gas.
C, washing
The argentiferous activated carbon fiber of washing behind this Pintsch process lasts 1 minute to 600 hours, and to remove the unnecessary silver in activated carbon fiber surface, then, the activated carbon fiber after the oven dry washing makes and carries a silver-colored activated carbon fiber.
Through year silver-colored activated carbon fiber that said method makes, its BET specific surface area is more than 400 meters squared per gram, and carbon content is more than 50 percentage by weights, and silver content is more than 0.001 percentage by weight of activated carbon fiber, and density is more than the 1.8 gram/cubic meters.In said method, can adopt the prepared activated carbon fiber of the material that is selected from following group to implement: polyacrylonitrile fibre, cellulose fibre, pitch fibers, phenolic fibre and combination thereof.
The correlative detail of above-mentioned preparation method can be announced (TW 0059115) No. 0059115 with reference to the TaiWan, China patent of invention.In addition, about carrying the preparation of silver-colored activated carbon fiber, also can be with reference to as Japanese kokai publication hei 10-99678, A.Oya, T.Wakahara, and S.Yoshida, Carbon, 31,1243-1247,1993, Fu, R., H.Zeng, and Y.Lu, " Studies on the Mechanisms ofthe Reaction of Activated Carbon Fibers with Oxidants, " Carbon, 32 (4), 593-598 (1994), and Wang, Y.L., Y.Z.Wan, X.H.Dong, G.X.Cheng, H.M.Tao, and T.Y.Wen, " Preparation and Characterization of AntibacterialViscose-based Activated Carbon Fiber Supporting Silver; " Carbon, 36 (11), 1567-1571 documents such as (1998).The aforementioned data content is all and in herein for your guidance.
Method two:
Use three utmost point electro-chemical systems, auxiliary electrode is that titanium lily gilding, working electrode are that graphite, reference electrode then are netted silver-colored line, and wherein reference electrode is positioned at the working electrode top.And electrolyte adopts AgNO
3Be made into 0.001M in the water-soluble solution of solid.Graphite flake, activated carbon fiber, carbon fiber or graphite fibre contained be immersed in the electrolyte, with the overpotential of-20mV and use the pulsed plating mode, through 5 to 100 circulations, can on graphite flake, activated carbon fiber, carbon fiber or graphite fibre surface, plate out the silver-colored granule below the particle diameter 200nm.
Method three:
Use the two poles of the earth method electro-chemical systems, wherein, two electrodes are all graphite flake.Graphite flake, activated carbon fiber, carbon fiber or graphite fibre be impregnated in the AgNO of 0.001M
3In the plating bath, electroplate and last 10 seconds with the-supply electric current of 5mA, can on graphite flake, activated carbon fiber, carbon fiber or graphite fibre surface, plate the silver-colored granule below the particle diameter 200nm.
If for the carbonaceous material fibre morphology that is loaded with precious metal that wound covering thing of the present invention uses, it can have fibrous, cloth shape, felted, band shape or yam-like.Optionally, can directly there be the composite fibre of this carbon fibre to make Woven fabric (woven fabrics with this carbon fibre or with blending, as carrying silver-colored activated carbon fiber cloth) or supatex fabric (non-woven fabrics), perhaps this carbon fibre or blending there is the composite fibre of this carbon fibre, merges with optionally resin material and make carbon fiber paper, so that covering of the present invention to be provided, omit the use of substrate layer.In addition, also this carbonaceous material can be mixed in polymeric material, so that the one layer or more as the wound covering thing of artificial skin (synthetic skin) to be provided.
When the substrate layer of wound covering thing is porous substrate, can be continuously or the mode of discontinuity layer, the carbonaceous material that is loaded with precious metal is imposed at least a portion of base material first surface.Say it (but not as limit) for example, the carbonaceous material that is loaded with precious metal can be mixed with the first adhesive agent composition, again this mixture is coated on the substrate layer first surface, with combining of enhancement carbonaceous material and substrate layer.In this, if when this mixture layer uses in the wound covering thing is actual can with wound or its contact skin on every side, then this first adhesive agent composition should be selected the not adhesive agent of Diazolidinyl Urea for use, is preferably the pressure-sensitive adhesive agent.Perhaps, can earlier this first adhesive agent be coated on the base material first surface, the carbonaceous material that will be loaded with precious metal again is applied on this adhesive agent.If carbonaceous material is the carbon fibre fabric as the cloth shape, then can pass through as ultrasound hot melt modes such as (ultrasonic welding) with pressing this carbon fibre tissue layer and substrate layer, perhaps by using extra adhesive layer to bind these two layers.Thereby, the stretch tight wound covering thing of form as O.K. is provided.
When the substrate layer of wound covering thing is a medicament can not penetrating type the time, then can directly be applied at least a portion of base material first surface with the carbonaceous material that is loaded with precious metal with single material bed layer of carbonaceous material form.In this,, then can the tissue layer form this carbon fibre be applied at least a portion of base material first surface, by making carbon fibre layer and base material pressing as ultrasound hot melt modes such as (ultrasonicwelding) if this carbonaceous material is carbon fibre.Wherein, this tissue layer is made up of this carbon fibre and natural and/or staple fibre, or for only containing the fabric of carbonaceous fiber.Can be if necessary in using extra adhesive layer between base material first surface and layer of carbonaceous material, to bind layer of carbonaceous material and this first surface; Also can be in layer of carbonaceous material directly and contain adhesive agent.In this, if when layer of carbonaceous material is used in the wound covering thing is actual can with wound or its contact skin on every side, then and the adhesive agent that contains should select the not adhesive agent of Diazolidinyl Urea for use, be preferably the pressure-sensitive adhesive agent.
The general known pressure-sensitive adhesive agent that is applied to the wound covering thing all can be used in the present invention, for example, is disclosed in US 4,675,009, US 5,536,263, US 4,696,854, US 5,741,510 and US 6,495, the pressure-sensitive adhesive agent of 158B1, the content of aforementioned patent is all and in herein for your guidance.Say it (but not as limit) for example, can adopt the following pressure-sensitive adhesive agent that can be used for the percutaneous patch in the present invention: polyacrylate, siloxanes or poly-isobutyl diene etc.The above-mentioned pressure-sensitive adhesive agent that these are applicable to the percutaneous patch can be referring to as Handbook of Pressure Sensitive Adhesive Technology, 2
NdEdition (1989) Van Nostrand, Reinhold, the disclosure thing content and in herein for your guidance.
Wound covering thing of the present invention can optionally contain other therapeutic activity composition in addition, and the additional procedures benefit is provided.This therapeutic activity composition can and be contained in identical with the carbonaceous material that is loaded with precious metal material bed in, or be present in different layers.If therapeutic activity composition system exists respectively with this carbonaceous material, and be stored in the independent medicament layer, then the layer of carbonaceous material that contains this carbonaceous material can be placed between substrate layer and this medicament layer (as described above, this substrate layer can be porous substrate, and this carbonaceous material can be coated on this base material), and this medicament layer contains the pressure-sensitive adhesive agent composition that is applicable to the percutaneous patch in addition.Perhaps, this layer of carbonaceous material can be sandwiched in two medicament layers middle (that is, settling in the mode of substrate layer, medicament layer, layer of carbonaceous material, medicament layer in regular turn), respectively this medicament layer can contain identical or different therapeutic activity composition and pressure-sensitive adhesive agent composition.
Any therapeutic activity composition in order to the treatment skin wound all can be applied to wound covering thing of the present invention.Say it (but not as limit) for example, can comprise in the therapeutic activity composition that is applied to wound covering thing of the present invention: erythromycin (erythromycin), tetracycline (tetracycline), clindamycin (clindamycin), cephalosporin (cephalosporin), acrisorcin (acrisorcin), Chlorphenesin (haloprogin), nioform (iodochlorhydroxyquin), tinea is moved back the antimycotic agent of (tolnaftate) and triacetyl glycerine (triacetin) etc., and as Gotu Kola (centella asiatica), econazole nitrate (econazole nitrate), ammonia Bian sulfanilamide (mafenide), a Luo Xin (mupirocin) not, the wound of Pu Weilong iodine (povidone iodine) etc., the pharmaceutical compositions of burning or scalding.
Optionally, wound covering thing of the present invention can contain a protective layer in addition in the outer surface of material bed (it can be medicament layer, layer of carbonaceous material or independent adhesive layer) of containing the pressure-sensitive adhesive agent, to protect this material.This protective layer can be single material bed, or for having at least a part eclipsed two material bed.Any known protective layer that can be used for the wound covering thing all can be applied to the present invention.Say it (but not as limit) for example, the thin film that can use following one or more material to constitute is protective layer: polyolefin, polyurethane, nylon, polyamide, poly-cellulose, polrvinyl chloride, polyvinyl dichloride, polyolefin (as ethylene vinyl acetate copolymer, polyethylene and polypropylene), polyureas and polyester (as polyethylene terephthalate) etc.
The existing skill that wound covering thing of the present invention is continued to use is only done quoting of emphasis formula at this, to assist elaboration of the present invention.Its technical characterictic and content further specify conjunction with figs., but relevant drawings also draws according to actual ratio, and its effect is only giving expression to feature of the present invention.
Fig. 1 represents the side view of an embodiment of wound covering thing of the present invention, and it is the patch (1) of treatment wound.This patch (1) comprise have first surface (11) and second surface (12) substrate layer (10), be positioned at the antimicrobial layer (20) of this first surface (11) and be positioned at the protective layer (40) of antimicrobial layer (20) top.This antimicrobial layer (20) comprises pressure-sensitive adhesive agent (not shown) and carries silver-colored carbonaceous material (30), and can optionally contain as the treatment wound in addition, burn, the therapeutic activity composition (not shown) of burn and scald, this carbonaceous material can be activated carbon, graphite, carbon or its combination, is preferably activated carbon, porous graphite or its combination.Say it (but not as limit) for example, can adopt activated carbon fiber, powder or granular bamboo carbon and/or as the porous graphite of soft graphite or expanded graphite.When using this patch (1), earlier protective layer (40) is torn off antimicrobial layer (20), the side with patch (1) tool antimicrobial layer (20) sticks in human body wound or affected part again.
Fig. 2 represents the side view of another embodiment of wound covering thing of the present invention; wherein, patch shown in (1) comprise have first surface (11) and second surface (12) substrate layer (10), be positioned at this first surface (11) antimicrobial layer (20), be overlying on the medicament layer (50) on this antimicrobial layer (20) and be positioned at the protective layer (40) of medicament layer (50) top.This medicament layer (50) comprises the therapeutic activity composition (not shown) and the pressure-sensitive adhesive agent (not shown) for the treatment of burn and scald, and this antimicrobial layer (20) then comprises year silver-colored carbonaceous material and adhesive agent is optionally formed.This carbonaceous material can be activated carbon, graphite, carbon or its combination, is preferably activated carbon, porous graphite or its combination.Say it (but not as limit) for example, can adopt activated carbon fiber, powder or granular bamboo carbon and/or as the porous graphite of soft graphite or expanded graphite.When using patch (1), earlier protective layer (40) is torn off medicament layer (50), the side with patch (1) tool medicament layer (50) sticks in human body wound or affected part again.Can between substrate layer (10) and antimicrobial layer (20), contain medicament layer in addition.
Fig. 3 represents another embodiment side view of wound covering thing of the present invention, is depicted as gauze (100), and Fig. 3 A is the local amplification plan view of gauze (100).Shown in Fig. 3 and Fig. 3 A, this gauze (100) comprises the fabric substrate layer (110) of have first surface (111) and second surface (112) and is coated on the antimicrobial coatings (120) of this first surface (111) at least a portion.Wherein this antimicrobial coatings (120) comprises year a silver-colored carbonaceous material (not shown) and a pressure-sensitive adhesive agent (not shown).This carbonaceous material can be activated carbon, graphite, carbon or its combination, is preferably activated carbon, porous graphite or its combination.Say it (but not as limit) for example, can adopt activated carbon fiber, powder or granular bamboo carbon and/or as the porous graphite of soft graphite or expanded graphite.In this embodiment, when this year, silver-colored carbonaceous material was carbon fibre, can directly this carbon fibre be incorporated in the fiber that base material (110) are provided, or directly provide base material (110) with this carbon fibre, omit adhesive agent even extra fibrolaminar use.
Fig. 4 represents another embodiment sketch map of wound covering thing of the present invention, is depicted as O.K. and stretches tight (200), Figure 5 shows that along the sectional view of Fig. 4 line 5-5.As Fig. 4 and shown in Figure 5, this O.K. stretch tight (200) comprise the substrate layer (210) of have first surface (211) and second surface (212), the pressure-sensitive adhesive layer (220) that is coated on this first surface (211), the preferable antimicrobial fabric layer (230) that is positioned at substrate layer (210) central authorities, and the eclipsed protective layer of two at least a portion (240).Wherein, antimicrobial fabric layer (230) is a gauze layer, and it comprises a year silver-colored carbon fibre, is preferably to carry a silver-colored activated carbon fiber.Though show antimicrobial layer (230) with the gauze form herein, antimicrobial layer (230) also can be flexible carbonaceous material thin slice or is to contain the adhesive-bonded fabric or the fibrous paper of carrying silver-colored carbon fibre.Optionally, can on antimicrobial layer (230), use the medicament layer (not shown) of the pharmaceutical compositions that comprises other treatment wound, burns or scald in addition, so that extra therapeutic effect to be provided.
In wound covering thing of the present invention, when the employing precious metal when being carried on activated carbon or the porous graphite, can initiatively adsorb, assemble microorganism near the wound covering thing by activated carbon/porous graphite in its surface, be adsorbed/accumulative microorganism with its surface institute's precious metal that carried destruction then, wound is in is close to aseptic condition, promote that wound heals, reduces cicatrix early.In addition, when adopting activated carbon with the carrying precious metal, because of activated carbon can absorb moisture (reaching 5 to 20 weight % usually), above-mentioned these moisture content can activate its surface precious metal that carries, so can be in not needing volume to add moisture content or adopting this precious metal of activation under the situation of other measure, in easy relatively mode, reach the microbicidal benefit of institute's desire.
The present invention provides a cover group in addition, and it comprises aforementioned wound covering thing of the present invention, and retaining element.But this obducent instrument of any localized immobilization all can be in order to provide this retaining element.Say it (but not as limit) for example, this retaining element can be adhesive tape, binder, patch or the like.
The present invention also provides for the antimicrobial compositions that is locally applied to skin, and it comprises carbonaceous material and is carried on the precious metal of the effective dose of this carbonaceous material.Wherein, this carbonaceous material is selected from following group: activated carbon, graphite, carbon and combination thereof are preferably activated carbon, porous graphite or its combination.Say it (but not as limit) for example, can adopt activated carbon fiber, powder or granular bamboo carbon and/or as the porous graphite of expanded graphite or soft graphite.This precious metal is selected from following group: silver, gold, palladium, platinum, copper, zinc and combination thereof, and be preferably silver.
In the present composition, this precious metal content that is carried on carbonaceous material is not key point, as long as its content can provide the microbicidel of being desired benefit.With the weight of precious metal itself, be generally 0.0001 to 30 weight % of compositions gross weight, be preferably 0.001 to 10 weight %.This precious metal is preferable to be carried on carbonaceous material with particulate form, precious metal ion for more effective release tool microbiocidal activity, this noble metal particles is preferable to be carried on the carbonaceous material with the particulate form with nano-scale, and particle diameter is no more than 200 nanometers, be more preferred from and be no more than 100 nanometers, best for being no more than 50 nanometers.
Optionally, can in the present composition, contain the therapeutic activity composition for the treatment of effective dose in addition, for example, but be not limited to, antibacterial, antimycotic agent or other wound, burn or the treatment of scald composition.Say it (but not as limit) for example, can optionally make the present composition contain erythromycin (erythromycin), tetracycline (tetracycline), clindamycin (clindamycin), cephalosporin (cephalosporin), triclosan (triclosan), phenoxy group isopropyl alcohol (phenoxyisopropanol), hibitane Gluconate (chlorhexidine gludonate), povidon iodine (povidone iodine), acrisorcin (acrisorcin), Chlorphenesin (haloprogin), nioform (iodochlorhydroxyquin), tinea is moved back (tolnaftate), triacetyl glycerine (triacetin), Gotu Kola (centella asiatica), econazole nitrate (econazole nitrate), ammonia Bian sulfanilamide (mafenide), not a Luo Xin (mupirocin) and Pu Weilong iodine (povidone iodine) etc.
Except that active component, the present composition can contain the non-toxicity that is suitable for local application in addition, pharmaceutically reach all acceptable supporting agent, diluent and excipient on the skin.Aforementioned supporting agent, diluent and excipient, and the standard dose of known pharmacological reagent all can be with reference to U.S. Pat 6,692, and the relevant Teaching-with of 773B2 shows, above-mentioned these contents and in herein for your guidance.
Topical composition of the present invention can various dosage form exist, for example: gel, pastel, ointment, cream, emulsion and suspension etc.Can be desired dosage form to provide by other active component that under aseptic condition, mixes the carbonaceous material be loaded with precious metal and pharmaceutically acceptable supporting agent, diluent or excipient and optionally exist.Say it (but not as limit) for example, aqueous or oiliness substrate, the suitable thickening agent of interpolation or gellant be can adopt and facial film, ointment or cream mixed, wherein, can water by aqueous base at the bottom of and look and adopted substrate essence, can use to be thickening agent as aluminum foil stearate and hydrogenated lanolin etc.Can adopt as starch, Tragacanth (tragacanth), cellulose derivative, Polyethylene Glycol, polysiloxanes (silicones), bentonite, silicic acid (silicic acid), Talcum and composition thereof etc. is excipient, and the present composition of agent shapes such as pastel, ointment, cream or gel is provided.
Should understand that the maximum difference of the present composition and known technology is to make with the form through carbonaceous material carrying the precious metal of apparatus microbicidel characteristic.Wherein, when adopting activated carbon to be this carbonaceous material,,, provide the sterilization benefit so the present composition can activate these precious metals under the situation of additionally not adding moisture content because of activated carbon contains moisture.In addition, when with activated carbon/when porous graphite is carbonaceous material, because of activated carbon/porous graphite can be assembled microorganism, only can be so can change above-mentioned these precious metals in the " passiveness " benefit of microorganism " just " through out-of-date kill microorganisms, with the form of making an initiative sally, positive the elimination of micro-organisms.Therefore, the present invention applicable to any known with above-mentioned these precious metals be locally applied to skin with the elimination of micro-organisms, suppress the situation of growth of microorganism, excellent relatively microbicidel benefit is provided.
Though the present invention has disclosed as above, so its also unrestricted the present invention, any person of ordinary skill in the field in not breaking away from spirit of the present invention and scope, change and improvement when doing, so protection scope of the present invention is as the criterion when looking the claim person of defining.
Claims (21)
1. wound covering thing, it is characterized in that the precious metal that comprises carbonaceous material and be carried on this carbonaceous material, wherein, this carbonaceous material is selected from following group: activated carbon, graphite, carbon and combination thereof, and this precious metal is selected from following group: silver, gold, palladium, platinum, copper, zinc and combination thereof.
2. covering according to claim 1 is characterized in that this carbonaceous material is selected from following group: activated carbon, porous graphite and combination thereof.
3. covering according to claim 2 is characterized in that this porous graphite is selected from following group: soft graphite, expanded graphite and combination thereof.
4. covering according to claim 1 it is characterized in that this precious metal is a silver, and its particle diameter is no more than 200 nanometers.
5. covering according to claim 1 is characterized in that comprising in addition flexible substrate, and this flexible substrate has first surface and second surface, and wherein, this carbonaceous material that is loaded with precious metal is overlying at least a portion of this first surface.
6. covering according to claim 5 is characterized in that this carbonaceous material that is loaded with precious metal attaches to this first surface by first adhesive agent.
7. covering according to claim 5 is characterized in that comprising second adhesive agent in addition, is overlying on this carbonaceous material.
8. covering according to claim 6 is characterized in that comprising second adhesive agent in addition, is overlying on this carbonaceous material.
9. according to each described covering in the claim 1 to 8, it is characterized in that comprising in addition the therapeutic activity composition.
10. covering according to claim 9 is characterized in that this therapeutic activity composition is selected from following group: erythromycin, tetracycline, clindamycin, cephalosporin, acrisorcin, Chlorphenesin, nioform, tinea are moved back, triacetyl glycerine, Gotu Kola, econazole nitrate, ammonia Bian sulfanilamide, a not Luo Xin, Pu Weilong iodine and combination thereof.
11. covering according to claim 1 is characterized in that this covering is Woven fabric, supatex fabric or artificial skin.
12. covering according to claim 1 is characterized in that this carbonaceous material tool is selected from the form of following group: powder, granule, fiber, thin slice and combination thereof.
13. a cover group is characterized in that comprising wound covering thing according to claim 1, and retaining element.
14. cover group according to claim 13 is characterized in that this retaining element is adhesive tape, binder or patch.
15. a confession is locally applied to the antimicrobial compositions of skin, the precious metal that it is characterized in that the effective dose that comprises carbonaceous material and be carried on this carbonaceous material, wherein this carbonaceous material is selected from following group: activated carbon, graphite, carbon and combination thereof, and this precious metal is selected from following group: silver, gold, palladium, platinum, copper, zinc and combination thereof.
16. antimicrobial compositions according to claim 15 is characterized in that this carbonaceous material is selected from following group: activated carbon, porous graphite and combination thereof.
17. antimicrobial compositions according to claim 16 is characterized in that this porous graphite is selected from following group: soft graphite, expanded graphite and combination thereof.
18. antimicrobial compositions according to claim 17 it is characterized in that this precious metal is a silver, and its particle diameter is no more than 200 nanometers.
19. antimicrobial compositions according to claim 15 is characterized in that comprising in addition the therapeutic activity composition.
20. antimicrobial compositions according to claim 19 is characterized in that this therapeutic activity composition is selected from following group: erythromycin, tetracycline, clindamycin, cephalosporin, acrisorcin, Chlorphenesin, nioform, tinea are moved back, triacetyl glycerine, Gotu Kola, econazole nitrate, ammonia Bian sulfanilamide, a not Luo Xin, Pu Weilong iodine and combination thereof.
21. antimicrobial compositions according to claim 20 is characterized in that in order to form facial film.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610152642 CN100998888A (en) | 2006-01-09 | 2006-09-25 | Antimicrobe composition and vulnus coverage |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200610000656.9 | 2006-01-09 | ||
| CN200610000656 | 2006-01-09 | ||
| CN 200610152642 CN100998888A (en) | 2006-01-09 | 2006-09-25 | Antimicrobe composition and vulnus coverage |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310008345.7A Division CN103182098B (en) | 2006-01-09 | 2006-09-25 | Antimicrobial composition and wound coverture |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN100998888A true CN100998888A (en) | 2007-07-18 |
Family
ID=38257762
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200610152642 Pending CN100998888A (en) | 2006-01-09 | 2006-09-25 | Antimicrobe composition and vulnus coverage |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100998888A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103889469A (en) * | 2011-09-02 | 2014-06-25 | 布吕歇尔有限公司 | Wound dressing with an antimicrobial effect |
| CN103889379A (en) * | 2011-08-24 | 2014-06-25 | 卡尔冈碳素公司 | Activated carbon containing wound dressing |
-
2006
- 2006-09-25 CN CN 200610152642 patent/CN100998888A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103889379A (en) * | 2011-08-24 | 2014-06-25 | 卡尔冈碳素公司 | Activated carbon containing wound dressing |
| CN103889469A (en) * | 2011-09-02 | 2014-06-25 | 布吕歇尔有限公司 | Wound dressing with an antimicrobial effect |
| CN103889469B (en) * | 2011-09-02 | 2016-09-14 | 布吕歇尔有限公司 | There is the wound dressing of antibacterial action |
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