CN100575325C - Cable type extractor according cycling extraction method is extracted the method for eggplant Buddhist nun alcohol in the biomass - Google Patents
Cable type extractor according cycling extraction method is extracted the method for eggplant Buddhist nun alcohol in the biomass Download PDFInfo
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- CN100575325C CN100575325C CN200710019427A CN200710019427A CN100575325C CN 100575325 C CN100575325 C CN 100575325C CN 200710019427 A CN200710019427 A CN 200710019427A CN 200710019427 A CN200710019427 A CN 200710019427A CN 100575325 C CN100575325 C CN 100575325C
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Abstract
The solvent extraction extracting method of eggplant Buddhist nun alcohol is an extraction solvent with the sherwood oil in the biomass, is extraction plant with the cable type extractor according: 1, the extraction flask heating of cable type extractor according bottom is made the extraction agent volatilization; 2, to the condensation of prolong place, on the raw material of residual titration in the extractor, the extraction agent that soaked raw material accumulates in the extractor evaporable extraction agent by vapour pipe; 3, the extraction agent in the extractor is got back in the extraction flask by siphon pipe; Carry out above step repeatedly to extracting fully; 4, the extraction agent in the extraction flask is moved into vacuum distillation apparatus, reclaim extraction agent and recycle, obtain the crude product solanesol extract simultaneously.Eggplant Buddhist nun ethanol-extracted rate of the present invention 〉=78%, the sherwood oil rate of recovery 〉=96%.Product extraction yield, solvent recovering rate all increase, and greatly reduce extracting cycle.With the sherwood oil is solvent, and effect is better than traditional normal hexane, and price is that ideal extracts solvent far below normal hexane simultaneously, and production cost is lower, and can not throw into question to environment.
Description
Technical field
The present invention relates to extraction of effective components in a kind of biomass, the solvent extraction extracting method of eggplant Buddhist nun alcohol in particularly a kind of biomass.
Background technology
Eggplant Buddhist nun alcohol is one four sesquiterpenoid, and its molecular formula is C
45H
74O, molecular weight is 630, is a kind of undersaturated isopolyprenols, synthetic difficulty is very big, can only rely on from biomass such as leaf to extract, and mainly is to obtain from tobacco leaf, silkworm excrement, leaf of potato.
Eggplant Buddhist nun alcohol has important effect in biological chemistry and pharmaceutical chemistry.Because eggplant Buddhist nun alcohol itself contains the two keys of a plurality of non-public yokes, have the effect that unusual intensive absorbs free radical, be the very high many carbenes alcohol of a kind of pharmaceutical use, have antiulcer agent, medical effect such as antitumor.Pharmacological evaluation proves: eggplant Buddhist nun alcohol can produce the inhibition effect to the propagation of cancer cells.As anticancer preparation, eggplant Buddhist nun alcohol does not have cytotoxicity, and security is good, can use continuously, can control the cancer agent with other yet and use simultaneously, to reach better effect.Simultaneously, eggplant Buddhist nun alcohol also is a kind of important medicinal intermediates.Studies show that in recent years is as the ubiquinone of natural antioxidants
10In the treatment cardiovascular system diseases, there is unique curative effect aspects such as cancer and hepatopathy, and eggplant Buddhist nun alcohol is the synthetic ubiquinone that obtains
10, VK
2Essential raw material Deng medicine.These medicines have drug effects such as reducing blood cholesterol levels, antiulcer agent, hypertension, antitumor, antianaphylaxis, anti-inflammation, can be used for treating treatment of diseases such as pancreatitis, gastritis, heart trouble and acquired immune deficiency syndrome (AIDS).
From biomass, extract eggplant Buddhist nun alcohol, can not only obtain a kind of important medical material, and can turn waste into wealth, improve the related industries added value, have important use and be worth and practical significance.With the tobacco industry is example, and the cultivated area and the output of China's tobacco plant all occupy first place in the world.Plantation of tobacco and product processing play an important role in the national economic development, and the tobacco of plantation mainly is used as cigarette both at home and abroad at present.The annual yield of tobacco 450 of China～5,000,000 tons wherein has tankage such as 25% tobacco leaf, offal to go out of use approximately, can not be used for production of cigarettes, estimates that only the tobacco waste in Yunnan Province just has more than 600,000 tons approximately.Therefore, the comprehensive utilization of strengthening tobacco waste not only can make this part refuse become valuable resource, also can improve the sound development of tobacco grower's income and tobacco industry, and extract eggplant Buddhist nun alcohol from tobacco (especially abandoned tobacco), be exactly a feasible thinking.Be example again with the silkworm excrement, China's silkworm excrement aboundresources, the annual bright silkworm excrement tons up to a million that obtain from sericulture, only the bright silkworm excrement amount of the province in Sichuan is just up to more than 400,000 tons/year, and average every silkworm egg produces air-dry silkworm excrement 7714 grams, extracts eggplant Buddhist nun alcohol from silkworm excrement, turn waste into wealth, resources advantage is converted into economic advantages, promotes the silkworm development of helping already, have considerable economic and social benefit.
Summary of the invention
The present invention is a raw material to contain eggplant Buddhist nun alcohol biomass, is solvent with sherwood oil (boiling range: 60 ℃～90 ℃), is device with the cable type extractor according, carries out extracting operation, extracts the eggplant Buddhist nun alcohol in the biomass, and the solvent sherwood oil can be recycled through regeneration.
The technical scheme of finishing the foregoing invention task is:
The solvent extraction extracting method of eggplant Buddhist nun alcohol in the biomass is an extraction solvent with sherwood oil (boiling range: 60 ℃～90 ℃), is extraction plant with the cable type extractor according, the steps include:
Step 1 makes extraction agent (solvent) volatilization to the extraction flask heating of cable type extractor according bottom;
To the condensation of prolong place, on the biomass material of residual titration in the extractor, the extraction agent that soaked raw material accumulates in the extractor by vapour pipe for step 2, evaporable extraction agent;
Step 3 was soaked the extraction agent of raw material and was got back in the extraction flask by siphon pipe in the extractor;
Carry out above step repeatedly, to extracting fully;
Step 4 moves into vacuum distillation apparatus with the extraction agent that extracts eggplant Buddhist nun alcohol in the extraction flask, reclaims extraction agent and recycles, and obtains dun crude product solanesol extract simultaneously.
The sherwood oil of vacuum still recovered overhead can be used as solvent cycle and uses, and the tower still is product-beige crude product solanesol extract.
Biomass material in the above technical scheme can be tobacco leaf or silkworm excrement.
More particularly, concrete operations step of the present invention is:
Adopt cable type extractor according shown in Figure 1, this device bottom is an extraction flask, interior dress extraction agent sherwood oil, and the middle part is an extractor, interior dress filter paper, filling is in right amount through pretreated eggplant Buddhist nun alcohol biomass tobacco leaf or the silkworm excrement of containing on the filter paper, and top is spherical condensating tube; In the leaching process, bottom round-bottomed flask 1 adopts the temperature control electrically heated, make solvent evaporates, and by vapour pipe 3 to prolong 6 places condensation residual titration in extractor 5, soak cellulose thimble 4, when the liquid level of residual titration was higher than siphon pipe 2, the extraction agent sherwood oil that contains extracting substance was back in the round-bottomed flask 1, finished a circulation; After the abundant extraction of for some time, collect the solution of bottom, move into vacuum distillation apparatus, reclaim solvent, obtain dun crude product solanesol extract simultaneously, adopt its composition of efficient liquid phase chromatographic analysis, gained crude product eggplant Buddhist nun alcohol content between 17～19%, eggplant Buddhist nun ethanol-extracted rate 〉=78%.
The technical process of leaching process is seen shown in Figure 2, and each device adopts and optimizes processing condition in the leaching process, can obtain technical grade crude product eggplant Buddhist nun alcohol after the extraction, while solvent sherwood oil reusable edible after reclaiming, the rate of recovery 〉=96%.
Advantage of the present invention: adopt process unit, flow process and optimized parameters shown in Fig. 1,2, raw material is the tobacco leaf (contain eggplant Buddhist nun alcohol and be about 1%) of prior porphyrize oven dry, with sherwood oil (boiling range: 60 ℃～90 ℃) is solvent, at first carry out continuous cycling extraction operation through cable type extractor according, after the abundant extraction of for some time, product distills processing through vacuum distillation apparatus in the still, can obtain technical grade crude product eggplant Buddhist nun alcohol (content 〉=17%), eggplant Buddhist nun ethanol-extracted rate 〉=78%, while solvent sherwood oil reusable edible after reclaiming, the rate of recovery 〉=96%.
Compare with traditional interrupted extraction flow process, cable type extractor according cycling extraction flow process is all increasing aspect product extraction yield, the solvent recovering rate, and what is more important greatly reduces extracting cycle.With the sherwood oil is solvent, all slightly is being better than the normal hexane that tradition is used aspect product extraction yield, the solvent recovering rate, and its price is that a kind of ideal extracts solvent far below normal hexane simultaneously.
Cable type extractor according cycling extraction method is extracted the method for eggplant Buddhist nun alcohol in the biomass and is compared with traditional method, and production cost is lower, and can not throw into question to environment.
Description of drawings
Fig. 1 is the cable type extractor according structure iron;
Fig. 2 is the flow process that cable type extractor according cycling extraction method is extracted eggplant Buddhist nun alcohol in the biomass.
Embodiment
Embodiment 1, adopt cable type extractor according shown in Figure 1, this device bottom 1 is extraction flask (round-bottomed flask), interior dress extraction solvent (sherwood oil) 500～600 milliliters, middle part 5 is an extractor, interior dress filter paper, through the pretreated eggplant Buddhist nun alcohol biomass (adopting the tobacco leaf 25 of prior porphyrize oven dry to restrain in the experimentation) that contains, top 6 is spherical condensating tube in right amount in filling on the filter paper.In the leaching process, bottom round-bottomed flask 1 adopts the temperature control electrically heated, the control Heating temperature is 100 ℃, make solvent evaporates, and by vapour pipe 3 to prolong 6 places condensation residual titration in extractor 5, soak cellulose thimble 4, when the liquid level of residual titration is higher than siphon pipe 2, solution (containing extracting substance) is back in 1, finishes a circulation.After 5～6 hours abundant extraction, it in the extractor biomass residue, it in the extraction flask petroleum ether solution that has dissolved eggplant Buddhist nun alcohol, solution in the receiving flask moves into vacuum distillation apparatus (working pressure is 0.01MPa), and cat head steams solvent (sherwood oil) and all reclaims, finally obtain dun crude product solanesol extract at the tower still, adopt its composition of efficient liquid phase chromatographic analysis, gained crude product eggplant Buddhist nun alcohol content between 17～19%, eggplant Buddhist nun ethanol-extracted rate 〉=78%.The technical process of leaching process is seen shown in Figure 2, and each device adopts and optimizes processing condition in the leaching process, can obtain technical grade crude product eggplant Buddhist nun alcohol after the extraction, while solvent sherwood oil reusable edible after reclaiming, the rate of recovery 〉=96%.
Embodiment 2, and is substantially the same manner as Example 1, but raw material is a silkworm excrement.
Claims (3)
1, the solvent extraction extracting method of eggplant Buddhist nun alcohol in a kind of biomass is an extraction solvent with the sherwood oil, is extraction plant with the cable type extractor according, the steps include:
Step 1 makes the extraction agent volatilization to the extraction flask heating of cable type extractor according bottom;
To the condensation of prolong place, on the biomass material of residual titration in the extractor, the extraction agent that soaked raw material accumulates in the extractor by vapour pipe for step 2, evaporable extraction agent;
Step 3 was soaked the extraction agent of raw material and was got back in the extraction flask by siphon pipe in the extractor;
Carry out above step repeatedly, to extracting fully;
Step 4 moves into vacuum distillation apparatus with the extraction agent that extracts eggplant Buddhist nun alcohol in the extraction flask, reclaims extraction agent and recycles, and obtains dun crude product solanesol extract simultaneously;
The boiling range of described sherwood oil is: 60 ℃～90 ℃.
According to the solvent extraction extracting method of eggplant Buddhist nun alcohol in the described biomass of claim 1, it is characterized in that 2, described biomass material is tobacco leaf or silkworm excrement.
3, according to the solvent extraction extracting method of eggplant Buddhist nun alcohol in claim 1 or the 2 described biomass, it is characterized in that the concrete operations step is:
Adopt cable type extractor according, this device bottom is an extraction flask, interior dress extraction agent sherwood oil, and the middle part is an extractor, interior dress filter paper, filling is in right amount through pretreated eggplant Buddhist nun alcohol biomass tobacco leaf or the silkworm excrement of containing on the filter paper, and top is spherical condensating tube; In the leaching process, bottom round-bottomed flask (1) adopts the temperature control electrically heated, make solvent evaporates, and locate the condensation residual titration in extractor (5) by vapour pipe (3) to prolong (6), soak cellulose thimble (4), when the liquid level of residual titration was higher than siphon pipe (2), the extraction agent sherwood oil that contains extracting substance was back in the round-bottomed flask (1), finishes a circulation; After the abundant extraction of for some time, collect the solution of bottom, move into vacuum distillation apparatus, reclaim solvent, obtain dun crude product solanesol extract simultaneously;
Wherein, the control Heating temperature is 100 ℃ in the step 1;
Step 3 is the abundant extraction through 5～6 hours;
The working pressure of step 4 is 0.01MPa.
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| Application Number | Priority Date | Filing Date | Title |
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| CN100575325C true CN100575325C (en) | 2009-12-30 |
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| CN102494935B (en) * | 2011-12-08 | 2014-01-29 | 上海烟草集团有限责任公司 | Method for determining resin and gooey in reconstituted tobacco pulp system of papermaking method |
| CN102861456A (en) * | 2012-09-25 | 2013-01-09 | 宁波大学 | Inner tube straight-through heat-gathering Soxhlet extractor |
| CN106477832B (en) * | 2016-11-11 | 2019-07-23 | 武汉纺织大学 | The method that tobacco leaf production draining separation solid emission extracts Salanesol |
| CN109622584B (en) * | 2018-12-27 | 2021-04-06 | 安徽建筑大学 | Soil heavy metal enrichment and extraction device and method based on cable extraction |
| CN114702435B (en) * | 2022-04-12 | 2024-03-19 | 长沙绿叶生物科技有限公司 | Preparation method of arecoline |
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Non-Patent Citations (2)
| Title |
|---|
| 天津大学硕士学位论文. 康锋，23-27. 2005 |
| 天津大学硕士学位论文. 康锋，23-27. 2005 * |
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