CN100553705C - The medicine discharger - Google Patents
The medicine discharger Download PDFInfo
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- CN100553705C CN100553705C CNB2007101291413A CN200710129141A CN100553705C CN 100553705 C CN100553705 C CN 100553705C CN B2007101291413 A CNB2007101291413 A CN B2007101291413A CN 200710129141 A CN200710129141 A CN 200710129141A CN 100553705 C CN100553705 C CN 100553705C
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Abstract
A kind ofly be used to discharge the medicine discharger that is included in the multiple medicine in a plurality of liquid reservoirs, comprise the medicine identification division of discerning medicine.Also provide deciding section, so that according to the combination of medicine of identification, the discharge order of described medicine is discharged in decision.In the medicine discharge section, discharge medicine in proper order with the discharge of deciding section decision.
Description
Technical field
The present invention relates to be used to control the method for the discharge of multiple medicine, and relate to the medicine discharger that to discharge multiple medicine.
Background technology
Ink-jet technology is widely known by the people as a kind of method of drain.For example, in heat spray method, to the liquid heat in the exhaust energy operation part that communicates with outlet, so that produce bubble, and these bubbles play a part by the outlet drain by heating resistor.In piezoelectric approach, piezoelectric element applies mechanical energy so that drain.Ink-jet technology is favourable, because can accurately control the size and the quantity of the drop of discharge, even they are very little.Therefore, wish ink-jet technology is applied to, for example, allow the suction apparatus (seeing U.S. Patent number 5,894,841) of striding the lung dispensing of pharmaceutical liquid.
Typical inhalant medicator comprises the quantitative aerohaler of suspended particulates type (MDI), dry-powder-type inhaler (DPI) and aerosol apparatus.
The some drugs discharger is not only discharged single composition, and discharges multiple material.For example, spray various compositionss, such as pharmacy mixture and accessory drugs or multiple pharmaceutical composition.These pharmacy mixture comprise treatment mixture, spice and last toner, and are used to use widely.
U.S. Patent number 6,684,880 disclose the discharger of discharging multiple medicine with ink-jet technology, and this device comprises a plurality of drug reservoir and corresponding to a plurality of discharge heads of each liquid reservoir.Drug reservoir keeps medicine, and can be simultaneously or a kind of a kind of after ground discharge a head discharge medicine from each.
If suck multiple medicine with unsuitable order unfortunately, then can not produce the effectiveness of expection.For example, suffering from asthma or bronchitic diabetics should at first suck bronchodilator so that expand bronchus with an inhaler, and sucks insulin then, so that increase the deposition of the insulin in the lung.Just do not suck insulin if at first do not suck bronchodilator, then the insulin drop of vast scale is blocked in bronchus, and can not arrive alveolar.When from alveolar with absorption of insulin to blood capillary, thereby when being transported by blood flow, insulin is effective.Yet if insulin is blocked in bronchus, it is absorbed lentamente by blood vessel, and the part of insulin may not absorbed by blood vessel.This is unfavorable for diabetics, although because it is important absorbing the insulin of scheduled volume at every turn, actual absorbed dose have reduced.
Yet, U.S. Patent number 6,684,880 above-mentioned only disclose a kind of after a kind of ground discharge multiple medicine, and openly do not discharge the order of different types of drugs or regularly.U.S. Patent number 6,684,880 discharger are not designed to discharge polytype medicine with suitable order.Therefore, the user of device need consider suitable suction order, and if user error ground considered this order, then can not suck with suitable order.
Summary of the invention
The medicine discharger that the invention provides a kind of method and implement this method, this method are used to control medicine discharges, thereby the user can simply He easily suck multiple medicine from single discharger with suitable order, and need not be considered especially.
The method of the discharge that is used to control at least two kinds of medicines is provided according to an aspect of the present invention.The method comprising the steps of: according to the combination of medicine, the discharge order of medicine is discharged in decision; And discharge first medicine in proper order, and discharge second medicine subsequently according to discharge.
According to another aspect of the present invention, provide a kind of discharge to be included in the medicine discharger of the multiple medicine in a plurality of liquid reservoirs.This device comprises: medicine identification division, its identification are included in the medicine in the liquid reservoir; Deciding section, it is according to the combination of the medicine that identifies, and the discharge order of medicine is discharged in decision; And the medicine discharge section, it is to discharge medicine in proper order by the discharge of deciding section decision.
Method and apparatus of the present invention allows the user easily and simply suitably to suck multiple medicine with the order that determines, and need not be considered especially.
From the description of carrying out below in conjunction with accompanying drawing, will understand other features and advantages of the present invention, wherein similar reference character refers to identical or similar part in these figure.
Description of drawings
Fig. 1 is the block diagram of the primary structure of medicine discharger according to an embodiment of the invention;
Fig. 2 is the sketch map of the box of medicine discharger according to an embodiment of the invention;
Fig. 3 is the axonometric chart that uses the inhaler of medicine discharger according to an embodiment of the invention;
Fig. 4 is the axonometric chart of the inhaler shown in Fig. 3 when access cover is opened;
Fig. 5 is the block diagram of medicine discharger according to an embodiment of the invention;
Fig. 6 is the flow chart that the order of medicine is discharged in the medicine discharger decision shown in Fig. 5;
Fig. 7 is the block diagram of medicine discharger according to another embodiment of the invention;
Fig. 8 is the block diagram of medicine discharger according to still a further embodiment;
Fig. 9 is the flow chart that the order of medicine is discharged in the medicine discharger decision shown in Fig. 7 or Fig. 8;
Figure 10 is to use the sparger type of piezoelectric element or the sketch map of dry powder discharging flask.
The specific embodiment
To describe the preferred embodiments of the present invention with reference to the accompanying drawings in detail now.
" ink-jet " herein referred to not only refers to discharge marking ink widely, but also comprises other liquid, such as pharmaceutical liquid." ink-jet " can be called " liquid jet ".
Fig. 1 is the block diagram of the primary structure of medicine discharger according to an embodiment of the invention.In the following description, the boxlike medicine discharger that description is comprised box.Described box comprises that an integrated cover keeps the liquid reservoir 1 of medicine and discharges 3.The medicine discharger can have a plurality of boxes, and the medicine discharger shown in Fig. 1 has two boxes 12 and 13.Liquid reservoir can be called container.The medicine discharger comprises the main body that comprises control section (CPU) 18.Control section comprises: medicine identification division 18a, and its identification is included in the interior medicine of liquid reservoir in the box; Deciding section 18b, the discharge order of medicine is discharged in its combination decision according to the medicine of being discerned by medicine identification division 18a; With driving governor 18c, the operation that head is discharged medicine is discharged in its control.Driving governor 18c sends signal controlling and discharges head, thereby discharges medicine according to the order of being determined by deciding section 18b from liquid reservoir.Therefore, box 12 and 13 medicine discharge section 3 begin to discharge multiple medicine according to the order of being determined by deciding section 18b.
According to an embodiment, a kind ofly be used to control method that medicine discharges and discharge the discharge order of at least two types of medicines according to the combination decision of medicine, and with the discharge order of decision a kind of another kind after ground discharge medicine.When sucking polytype medicine, should suck medicine with suitable order.For example, as mentioned above, when using the combination of bronchodilator and insulin, wish at first to suck bronchodilator, and be insulin then.If determined specific combination to finish this suitable suction for the method that the control medicine is discharged, then be identified for the discharge order of this combination, and the operation of medicine discharger, thereby discharge medicine with the order of decision.The medicine discharger of implementing this method is configured to the discharge order suitable according to the combination decision of the multiple medicine in the liquid reservoir, so that the control output mechanism is discharged medicine in proper order with this discharge.
Medicine discharger of the present invention uses a plurality of boxes, and each comprises a liquid reservoir.Box can comprise an integrated cover discharge head and a liquid reservoir.Can in the medicine discharger, provide the discharge head discretely with liquid reservoir.If the discharge head directly is provided in the medicine discharger, can arrange a plurality of discharge heads corresponding to each box, maybe can use single head.In the following description, box comprises liquid reservoir, and no matter liquid reservoir and to discharge head be integrated or isolating.The quantity of box can be set arbitrarily according to the drug type that for example once sucks.According to the combination of medicine, the discharge order can adopt various patterns.
For example, in the structure of three boxes with the liquid reservoir C that comprises the liquid reservoir A that comprises medicine a, the liquid reservoir B that comprises medicine b respectively, comprises medicine c, can discharge described medicine by the order of medicine a, b and c, maybe can by, for example, certain drug is discharged on the order several times ground of medicine a, medicine b, medicine a and medicine c.Can by, for example, the order of a, b, c, a, b and c repeats to discharge sequence.In addition, first medicine or second medicine can be discharged as one group of multiple medicine.More specifically, can be used as first medicine and discharge medicine a, and discharge medicine b and c simultaneously as second medicine then.Therefore can medicine discharge order be set arbitrarily and discharge number of times according to drug type.
Can stop the back in the discharge of first medicine and discharge second medicine, or discharge second medicine before can stopping in the discharge of first medicine.Under the former situation, discharge every kind of medicine separately, and once discharge a kind of medicine.In the latter case, do not begin or finish the discharge of first and second medicines, but the discharge of two kinds of medicines can overlapping a period of time in the accurate identical moment.
Combination according to the medicine that will discharge suitably is provided with the discharge sequence.
The medicine of herein referring to refers to have the medicinal mixture of pharmacy or physiological function, but also has taste or odour component, or dyestuff or colorant.Medicine can be liquid or powder.
The pharmaceutical liquid of herein referring to refers to liquid medicine or comprises the liquid media of pharmacy mixture.Pharmacy mixture in the liquid can be dissolved, dispersive, emulsive or suspend, and preferably be evenly distributed in the liquid.
When pharmaceutical liquid was used as medicine, the main medium of liquid can be water or organic material, and from the viewpoint of live body dispensing water preferably.
Said medicine mixture with physiological function can be normally used pharmacy mixture.The example of this pharmacy mixture comprises anti-inflammatory steroid, on-steroidal anti-inflammatory agent, tranquilizer, treating depression agent, analgesic, anti-bronchial asthma medicine, the agent of β sympathetic nerve, cholinolytic medicament, mast cell stabilizers and antagonistic.In addition, the pharmacy mixture comprises antitussive, expectorant, hydryllin, anti-allergic agent, Bendectin, hypnotic, vitamin mixtures, sex steroid hormone, anticarcinogen, arrhythmia medicament, hypertension agent, anti-worried agent, major tranquilizer, cardiac tonic and bronchodilator.In addition, the pharmacy mixture comprises bariatrician medicine, migraine agent, antirheumatic, protein preparation, hormone, cytokine, receptor, antibody, enzyme, enzyme inhibitor, vaccine, virus, antisense strand, gene and nucleic acid.
Though the quantity of medicine changes with every kind of material, its 1ppm that can be arranged on weight is in 10% scope of weight, and preferably in 0.001% to 5% scope of weight.
Taste of Shi Yonging or odour component comprise natural perfume material, synthetic perfume and mixture spice herein.Can also use general spice mixt, such as the spice that in cosmetics, soap and food, uses.Preferably use the medical spice that on pharmacopedics, is defined as subcomponent or allow to add to spice in food or the cosmetics.
Though change with every kind of spice as the spice of taste or odour component or the content of analog, usually it is set in the scope of 1ppb to 10% of weight, and preferably in the scope of the 1ppm to 1% of weight.In the intended purposes of drain, can be used in combination taste composition and odour component.
Various dyestuffs and pigment can be used as last toner, and preferably use the medical substances that is defined as subcomponent on pharmacopedics or allow to add to material in food or the cosmetics.
Though depend on the type of the last toner of use such as the content of the last toner of dyestuff and pigment, usually it is arranged in the scope of 1ppm to 30% of weight, and preferably in 0.01% to 10% scope of weight.In the intended purposes of drain, can be used in combination dyestuff and pigment.
If necessary, can add such as the additive of discharging adjuvant or absorption enhancer.Pharmacy mixture, spice or last toner can be the hydrophobic materials that does not show desirable solubility.In this case, can add dispersant, surfactant etc., thus dispersing hydrophobic material equably.In addition, the additive of the intended purposes that is suitable for drain be can add, agent, solvent, water-repellent agent and PH regulator revised such as dispersant, surfactant, surface conditioner, viscosity by proper proportion.
The example of the additive of Shi Yonging comprises ionic surface active agent, non-ionic surface active agent, emulsifying agent, dispersant, hydrophile adhesive mass, hydrophobic adhesive, hydrophilic thickening agent, hydrophobic thickener, glycerol, glycol and glycol derivant herein.In addition, additive comprises ethanol, aminoacid, carbamide, electrolyte and buffer composition.Can be separately or be used in combination the additive of listing above when needed.
In the use of this additive, preferably use the medical substances that on pharmacopedics, is defined as subcomponent or allow to add to material in food or the cosmetics.
The content of additive (based on quality) depends on pharmacy mixture as main component, as taste or the spice of odour component and the content and the type of last toner, and can be defined as follows.Usually, the additive content and more preferably is 0.1% to 20% of a weight preferably in 0.01% to 40% scope of weight.The quantity of additive can be provided with arbitrarily according to function, type and combination.Preferably, the quantity of additive is in the scope of 0.5 to 100 part of quality with respect to the gross mass of 1 part of pharmacy mixture, abnormal smells from the patient or taste composition and last toner.
As above prepare to fill the liquid component of a plurality of liquid reservoirs.Liquid in the liquid reservoir can be identical or different, but preferably different.More specifically, liquid can be pharmacy mixture and surfactant.Liquid component in each liquid reservoir can be the intermixture of pharmacy mixture, spice or last toner and additive, or the intermixture of the material of selecting from pharmacy mixture, spice or last toner.
Beginning time of discharge of first medicine and the interval (in one-period) that begins between time of discharge of second medicine can be provided with arbitrarily.Preferably, in producing its body, first medicine discharges second medicine after the effectiveness.Discharge second medicine when more preferably, in first medicine produces higher body, rendeing a service.Can interval be set to identical or change with each cycle.
If after the discharge of first medicine has stopped, discharging second medicine, stop time of discharge of first medicine and the time that begins between time of discharge of second medicine also can be provided with arbitrarily, but preferably in 1 second to 10 minutes scope.Be set to 1 second or more by this interval, the user need not suck two kinds of medicines only once between respiratory period, but can breathe second kind of medicine of suction with another after sucking first medicine and breathing subsequently.Yet after first medicine sucks 10 minutes or more time may weaken the effectiveness of first medicine at interval, or make the user forget suction second medicine.
The method that can compatibly control medicine of the present invention be sucked is applied to first medicine and strengthens situation about rendeing a service in the body of second medicine.The example that can strengthen the combination of rendeing a service in the body will be described below.
For example,, can after bronchus is fully expanded, suck second medicine, wish sedimentary position thereby second medicine can easily arrive if use bronchodilator as first medicine.Be intended to stride the medicine of lung absorption or the treatment of deep lung disease as second medicine if use.Can increase the deposition of this medicine in the lung.
Therefore, the user who suffers from asthma and diabetes simultaneously can suck bronchodilator, and sucks the medicine that comprises insulin or GLP-1 then.The example that is intended to be used to stride the medicine that lung absorbs comprises HGH, interferon and cytokine." insulin " herein referred to not only refers to common insulin widely, and refers to insulin analog and insulin derivates.The example of insulin comprises insulin, such as product, insulin lispro, thing insulin Glargine and the insulin Glargine of the aminoacid sequence with modification of insulin analog (aspart).In addition, also can use any peptides part of the insulin of referring to above of the biological nature of primary structure with whole or a part of above-mentioned substance and at least a portion insulin." GLP-1 " that herein refers to not only refers to conventional GLP-1 widely, and refers to the GLP-1 analog.
The example that is used for the treatment of the medicine of deep lung disease comprises antibiotic, steroid, cholinergic blocker and B2 analeptic.
Bioactive substance and can decompose or the combination of the inhibitor of the enzyme of metabolism biological active substance also is effective.For example, the DPP-4 inhibitor is to decompose the inhibitor that promotes the enzyme of the GLP-1 of insulin secretion in the body.Therefore, when according to the pharmaceutical liquid that comprises the DPP-4 inhibitor, and the order that comprises the pharmaceutical liquid of GLP-1 then is effective when discharging.The example of DPP-4 inhibitor comprises sitagliptin (sitagliptin), row spit of fland, Victor (vildagliptin) etc.
When second medicine has the effectiveness of restraining first side effects of pharmaceutical drugs also is effective.For example, if after sucking first medicine, produce inflammation, anti-inflammatory agent is restrained inflammation as second medicine.In addition, absorption enhancer can with drug regimen together so that strengthen to absorb.The combination of medicine and spice allows to confirm the discharge of medicine.The combination of multiple spice and aromatotherapy medicine can produce various effectiveness or new effectiveness.
Except striding lung absorbs, discharge control method of the present invention can be used for equally with lung transmitting medicine by mucosa to eyes, nasal cavity and oral cavity.
Can discharge three kinds of medicines.For example, discharge bronchodilator and DPP-4 inhibitor, and suck GLP-1 then.
When after the discharge at first medicine stops, beginning the discharge of second medicine, stop time of discharge of first medicine and the interval that begins between time of discharge of second medicine and preferably can be arranged on 0.00001 second in the scope of an imbibition cycle.In this case, every millisecond of convert packets is contained in the pharmaceutical liquid in each liquid reservoir, and discharges separately.By repeating this sequence, can repeatedly discharge different types of drugs liquid separately by each millisecond.
This method can be so that for example discharge of the combination of medicine, spice and analgesic, and alleviates the uncomfortable or dislike of being felt when sucking medicine.Therefore, the user can cosily suck medicine.Can only suck spice and analgesic in air-breathing beginning, and then every millisecond repeat to discharge spice, analgesic and medicine one by one.Therefore, the user can cosily suck medicine, and can not experience the bitterness of medicine.
Can by have program (such as the operation that is used to control discharge section, be stored in the computer executable program on the computer-readable medium) Electronic Control control the beginning of discharge and stop regularly.Therefore, can accurately control discharge pharmaceutical liquid quantity and discharge regularly, thereby and can high performance reproducibility, accuracy and concordance carry out and discharge.
Can be by vibrotechnique such as using piezoelectric actuator or ultrasound wave, or negative pressure technique bubbles and carries out Electronic Control such as carry out liquid by heat application.In the present invention can be by any technology transmit fluid.
Because method of the present invention allows a kind of multiple medicine of handling individually, the stability in needn't considering to store or preserve (so-called can service time).
Though in the above embodiments, described a plurality of liquid reservoirs keep different types of drugs, and they can keep identical medicine so that increase output.
Can apply heat energy to medicine by making electricity consumption-thermal conversion element, or use the vibration pressure of motor conversion component (for example, piezoelectric element) to apply mechanical energy discharge medicine to medicine.Can be according to the type selecting discharge method of medicine.
In the printer field, for convenience's sake, the technology that applies heat energy with electricity-thermal conversion element is called " hot ink ejecting method ", and is called " piezoelectric approach " with the technology that motor conversion component applies mechanical energy.These terms also are used for medicine discharges, but only means that the principle based on ink ejecting method applies the energy that is used to discharge.
Hot ink ejecting method can increase the quantity of the diameter of outlet, the pulse heat that is used to discharge, dimensional accuracy of the microheater that is used to heat etc., and the repeatability of each liquid discharge portion.Therefore, can realize discharge with the narrow distribution of drop size.In addition, reduce the manufacturing cost of head, thereby and can suitably hot ink ejecting method be applied to have the microcephaly's who needs frequent substitution device.Hot ink ejecting method need to be specially adapted to the liquid discharge device of portable and convenience.
Though the nozzle diameter of each discharge section can be arbitrarily, preferably the type according to the medicine of will discharge suitably is provided with this diameter.Suck for lung, must have diameter in scope 0.5 to 20 μ m according to the drop of the preparation of this embodiment, and can narrow distribution discharge.
Therefore, can change position in the lung that spraying arrived of drop.For drop is delivered to alveolar, this diameter is preferably about 2 to 3 μ m.For being delivered to bronchus or airway, this diameter is preferably about 7 to 8 μ m.
Therefore, this discharge control method allows to discharge and suck multiple medicine, thereby helps medicine to produce their whole effectiveness.
Referring now to the medicine discharger of accompanying drawing description according to an embodiment.This medicine discharger comprises deciding section, it is according to the combination of medicine, and the order that is included in the multiple medicine in each liquid reservoir is discharged in decision, and driving governor, the operation of its control medicine discharge section, thus from liquid reservoir, discharge medicine with the order of decision.
Fig. 2 is the sketch map according to the box of the medicine discharger of present embodiment.Box shown in Fig. 2 comprises discharge 3 (a medicine discharge section) that are used for drain, comprises the liquid reservoir 1 of liquid and liquid is delivered to from liquid reservoir 1 to discharge a liquid flow path 2 of 3.Discharge 3, liquid reservoir 1 and liquid flow path be arranged on the substrate together.Discharge 3 and connect 5 controller (driving governor) exchanges of discharging operation that can producing component with control by electronics and drive signal and control signal, inner wire 4 is connected to electronics and connects 5.
In an embodiment of the present invention, provide identification code 6, so that the medicine in the identification box to box.The identification code 6 of box can be that the bar code that is known as the code that can discern medicine, QR sign indicating number, RF label (are used for RF identification, RFID) or IC tag (being used for the IC chip).Can read identification code by the known technology that uses for example image, electricity or radio wave.Particularly, can be with CCD, CMOS equipment, electrically contact or antenna reads described sign indicating number.
Fig. 3 and 4 shows the inhaler as one type medicine discharger, and it has the size design that reduces, thereby is easy to be carried by the user.Fig. 3 is the axonometric chart of inhaler.This inhaler comprises controller, power supply (battery) of the main body 10 that comprises the medicine delivery cassette, box etc., be imported into and be used to the mouth 8, access cover 7 and the power knob 9 that suck in the mouth.The medicine delivery cassette has liquid reservoir as shown in Figure 2 and discharges the integrated group of head, and can change under the situation that access cover 7 is opened.Fig. 4 is the axonometric chart of inhaler when access cover opens 7. Box 12 and 13 is arranged as and air is communicated with from the air hose that air intake 11 imports air flow path.Medicine sprays as the discharge head of fine particles from box 12 and 13, and is mixed with each other in the air-flow by airway.In order to use inhaler, the user remains on mouth 8 in the his or her mouth and breathes, thereby and air enter through air intlet.
Structure shown in Fig. 3 allows the thin spraying of medicine drop to arrive throat and the trachea that sucks main body naturally with inhaled air.
Fig. 5 shows medicine discharger according to an embodiment of the invention.Fig. 5 has omitted medicine identification division, deciding section and the driving governor of control section 18.Fig. 6 shows the flow chart that is used for determining discharge process in proper order.Describe the process that is used for determining the discharge order in detail referring now to Fig. 5 and 6.At first the user presses power knob 9, and device energising (S100).Read the box identification code 14 and 15 (S101) of box 12 and 13 respectively with the reader (CCD) 16 and 17 of medicine discharger.Control section 18 is based on the medicine in the liquid reservoir of the box data identification box that transmits from reader, and the combination of definite medicine (S102).When box was not set, the device indication was provided with box.This device comprises memory portion (ROM) 19, and it stores the information of the suitable discharge order of drug regimen in table.Control section 18 is compared the data splitting that identifies and the information in the storage area 19, and according to the order (S103) of determining operating case at the suitable order of this combination.Preferably in memory cell 19, drive condition is set in advance, thereby control section 18 reference memory cell 19 are determined drive condition (S104) by the doctor.Control section 18 sends to each box according to the operating sequence of determining and drives signal, thus and operating case (S105) sequentially.
In another embodiment of the present invention, except the box recognition data, the medicine discharger can be controlled the discharge of medicine according to user data.In this embodiment, the medicine that the registered user uses in memory portion 19 in advance.Memory portion 19 storages are at the information and the user profile that is used for User Recognition of the discharge order of user's drug regimen.After by input user data identification specific user, the medicine identification division 18a of control section 18 knows the medicine of the registration that should discharge this user, and the medicine to comprise in above-mentioned definite each box of box identification.Thereby determine the operating sequence of box.To send to box according to the driving signal of operating sequence, and box is by the operation in tandem of determining.Can be with user biological information as user profile.For example, as shown in the block diagram of Fig. 7 and 8, iris and fingerprint can be compared as data.For example, read user's iris or fingerprint, and user data delivery is arrived control section 18 with reader such as CCD or fingerprint sensor.
Fig. 9 shows the flow chart of this process.After energized (S200), the input user data.For example, read user's iris or fingerprint, and user data delivery is arrived control section 18 (S201) with reader such as CCD or fingerprint sensor.By user's identification, this device is known the type (S202) of medicine.Then, with above-mentioned procedure identification box (S203), comprise what medicine (S204) in each box so that determine.Preferably in memory cell 19, drive condition is set in advance, thereby control section 18 reference memory cell 19 are determined drive condition (S205) by the doctor.Then, determine discharge order (S206), and will drive signal and be delivered to box based on the information in the memory portion (ROM) 19.Thereby operating case (S207) sequentially.
If will place what medicament storage in the box in memory portion 19, then can only determine the discharge order and need not discern box by User Recognition corresponding to box.
In another embodiment of the present invention, the user can import and use what medicine.By the input drug data, the control section of this device (medicine identification division 18a) obtains about maintaining the information of what medicine in the liquid reservoir.Then,,, and will drive signal and be delivered to each box from driving governor 19c so that determine the discharge order with the contrast of the information in this information and the memory portion 19, thus the order discharge medicine to determine.
In addition, discharge method can be stored in the memory portion in advance, and can be by extracting the necessary suitable discharge condition of Information Selection according to drug regimen.Replacedly, can fix predetermined discharge condition.
If the user knows the discharge information of when discharging second medicine after the discharge of first medicine finishes, the user can suck medicine and can be not anxious.The illustrative methods that is used for this purpose comprises, for example with led lighting, send audible signal, sound or music, the vibration of use vibrating motor or use character or image to show on panel with buzzer.For example, for demonstration information, wish to show the type of second medicine, time or discharge persistent period till when discharging beginning.
Can select the nozzle diameter (for example, outlet diameter) of the medicine discharge section of box arbitrarily, but can suitably it be provided with according to the type of the medicine of discharging by spout.
The operation of this device begins with single-unit activity basically.This activity is defined as setting device afterwards up to once throwing in the work of finishing.
Can synchronously begin the discharge of first medicine with user's suction, or begin by pressing button according to user's decision.Thereby since the controlled discharge of this device at first medicine begin after the definite order of basis automatically change discharge, the user can be by for example beginning to suck or the simple activities of pressing button sucks polytype medicine.
To describe example of the present invention now, but the invention is not restricted to these examples.
Example 1
Pharmaceutical liquid with two types of the discharges of the inhaler shown in Fig. 3.At first, the solution of following preparation dissolving or dispersion medicine.Use is prepared drain according to the solution of the medicament selection that will use.
Solution A: 2mg/mL lauryl creatine (lauroylsarcosine) aqueous solution
Solution B: 10mg/mL arginine monohydrochloride aqueous solution
Solution C: 10mg/mL zephiran aqueous chloride solution
Select salbutamol sulfate and insulin as the pharmacy mixture, and with its dissolving or be dispersed in solution A and B in so that prepare 0.5% and 0.4% drain respectively.Liquid is placed in the liquid reservoir of the box that is equipped with the QR sign indicating number separately that is used to discern.Box is inserted inhaler.Correctly discern box, and inhaler enters holding state.Determine with salbutamol sulfate and be that the order of insulin is discharged then.Because the intravital target site of people depends on medicine, need suitably select the size of drop, that is, and the nozzle diameter of discharge section.Carry out discharge with hot ink-jet (hot liquid injection) method, and be 7 μ m, and be 3 μ m for insulin fluid for salbutamol sulfate liquid nozzle diameter from each box.Two kinds of drains are set to 1.5 seconds from the interval between the discharge of discharge section.Start inhaler by pushing the power knob 9 shown in Fig. 3.After the discharge of salbutamol sulfate liquor stops, the discharge of beginning insulin solutions, thereby and two kinds of solution of independent discharge in ground after another.
Measure the particle size distribution and the interval of drain in particle size distribution (by the Spray Tec of Malvern manufacturing).As a result, the salbutamol drop has the average particle size of 7 μ m, and the insulin drop has the average particle size of 3.1 μ m.Operating time is consistent with the interval that is provided with at interval, that is, and and 1.5 seconds.Represent particle size distribution with the span value, and it being little, is 0.6 in each is discharged.(by the LC-2000 of JASCO company manufacturing) collects drain with HPLC (high performance liquid chromatography), and measures their concentration.As a result, the concentration of concentration and initial setting up, that is, 0.5% is consistent with 0.4%.
Therefore, discovery can be with single-unit activity, one after another ground with desirable liquid-drop diameter, discharge desirable medication amount with desirable interval.Table 1 shows experiment condition, measures the interval of concentration, average particle size and measurement.
Example 2 to 36
Except pharmacy mixture, solution, concentration is set and set interval change into as shown in table 1, carry out assessment in the mode identical with example 1.In table 1, except the DPP-4 inhibitor that uses in medicine A, for pharmacy mixture nozzle diameter is set to 7 μ m, and it is set to 3 μ m for the DPP-4 inhibitor.All nozzle diameters that are used for medicine B are set to 3 μ m.In these examples, DPP-4 inhibitor sitagliptin (sitagliptin).
As show as shown in the table 1 of interval of the concentration of average particle size, measurement of drop and measurement, even find to have changed the type and the interval of pharmacy mixture, also can be as example 1, with single-unit activity with desirable interval, discharge desirable medication amount with desirable liquid-drop diameter, one ground after another.
Comparative example 1
Except the discharger that never has deciding section or equivalent is discharged salbutamol sulfate liquor and the insulin solutions simultaneously, carry out assessment in the mode identical with example 1.The result has been shown in the table 1.
Though it is consistent with the desirable value of setting to measure concentration, particle size distribution is not desirable value.
Example 37
In example 37, alternately discharge two kinds of pharmaceutical liquids for every millisecond.Use menthol and insulin as the pharmacy mixture, and with its dissolving or be distributed to solution A and B in so that prepare 0.5% and 0.4% drain respectively.The diameter of two nozzles is set to 3 μ m.Manual operations decision by the user is discharged the order that head is discharged two kinds of drains from each.Alternately the discharge pattern is set to 1,000 circulation.Open inhaler by pushing the power knob 9 shown in Fig. 3, and carry out 1 second discharge with the frequency of 20KHz with the cascade ram that connects.The quantity of remaining medicine is determined particle size distribution from sieve.Speed with 28.3L/ minute provides air.The particle size distribution of measuring is consistent with the initial setting up value.
(by the LC-2000 of JASCO company manufacturing) collects drain with HPLC (high performance liquid chromatography), and measures their concentration.As a result, the concentration of concentration and initial setting up, that is, 0.5% is consistent with 0.4%.
Example 38 to 48
Except pharmacy mixture, solution, concentration is set and discharge number of cycles change into as shown in table 2, carry out assessment in the mode identical with example 37.All nozzle diameters of medicine A and B are set to 3 μ m.
As show as shown in the table 2 of concentration of the average particle size of drop and measurement, even find to have changed the type of pharmacy mixture and discharge number of cycles, also can be as example 37, with single-unit activity with desirable interval, discharge desirable medication amount with desirable liquid-drop diameter, one ground after another.
Comparative example 2
Except the discharger that never has deciding section or equivalent is discharged the drain simultaneously, carry out assessment in the mode identical with example 37.The result has been shown in the table 2.
Though it is consistent with the desirable value of setting to measure concentration, particle size distribution is not desirable value.
Example 49 to 55
In example 49 to 55, every millisecond alternately discharge two kinds of medicines before, first medicine is discharged certain time period.As shown in table 3, before alternately discharging, optionally carry out outside the discharge of pre-determined number of medicine A at Millisecond, carry out assessment in the mode identical with example 37 to 40.
As show as shown in the table 3 of concentration of average particle size and measurement, finding can be with single-unit activity with desirable interval, with desirable liquid-drop diameter, the desirable medication amount of ground discharge at another after in any example.
Example 56
Medicine A in the change example 37 and the discharge frequency of B.Except the discharge fixed-frequency with medicine A is 10kHz, and when discharging beginning, be 10kHz with the discharge frequency configuration of medicine B, thereby and to change gradually be outside the 25kHz when operation is finished, carry out assessment in the mode identical with example 37.The result is similar to the result of example 37.The concentration of measuring and the quantity of pharmacy mixture are consistent with the value of calculating according to the initial setting up value.
Example 57
Medicine A in the change example 49 and the discharge frequency of B.
Discharge frequency configuration with medicine A when discharging beginning is 20kHz, thereby and to change gradually be 10kHz when operation is finished.Discharge frequency configuration with medicine B when discharging beginning is 5kHz, thereby and to change gradually be 25kHz when operation is finished.Carry out assessment in the mode identical with example 49 and 56.The result is similar to the result of example 49, and as in example 56, drug concentrations is consistent with the value that calculates according to the initial setting up value with amount.
Example 58
In example 58, after the discharge of first medicine, will restrain the medicine of first side effects of pharmaceutical drugs as second medicine.Under the condition identical with example 49, alternately discharge menthol and insulin, and then alternately discharge finish after, discharge the medicine A of the example 20 in 3 seconds, cromoglicic acid.As a result, the concentration of particle size distribution and measurement is consistent with the desirable value of setting.
Example 59
Use piezoelectric ink jet (piezoelectric liquid injection) method of piezoelectric element as motor conversion component except discharge method is changed into from hot ink ejecting method, carry out assessment in the mode identical with example 1.The result is similar to example 1.
Example 60
Carry out as the box shown in Figure 10 of aerosol apparatus the discharge of medicine except use comprises net type piezoelectric element, carry out assessment in the mode identical with example 1.Piezoelectric element has known structure, and operates under desirable condition based on Given information.
Example 61
Except with known method salbutamol powder and insulin powder being carried out jet drying and classification, thereby these powder have in the example 1 outside the specified desirable particle size, carry out assessment in the mode identical with example 1.Powder is placed in the chamber 20 of the box shown in Figure 10.In each a plurality of hole of indoor formation, and, spray medicated powder with piezoelectric element 21 by these holes to be set to the medication amount identical with example 1.Piezoelectric element has known structure, and operates under desirable condition based on Given information.
Table 4 shows the result of example 1 and example 59 to 61.Method shows very little span value for hot ink-jet (hot liquid injection) and piezoelectric ink jet (piezoelectric liquid injection), and sparger type and dry-type show big span value, that is, and and broad particle size distribution.
Table 1
Table 4
Though reference example embodiment has described the present invention, should be appreciated that to the invention is not restricted to disclosed example embodiment.The scope of following claim will be endowed the wideest explanation, thereby comprises all modifications, equivalent structure and function.
Claims (10)
1. one kind is used to discharge the medicine discharger that is included in the multiple medicine in a plurality of liquid reservoirs, and this device comprises:
Medicine identification division, its identification are included in the described medicine in the described liquid reservoir;
Deciding section, it is according to the combination of the medicine of identification, and the discharge order of described medicine is discharged in decision; With
The medicine discharge section, it discharges described medicine with the discharge order of described deciding section decision,
Wherein, described device also comprises memory portion, it is stored the combination of multiple medicine and is rendeing a service the effectively information of discharge order at each combination, wherein said deciding section will be compared with the information that is stored in the described memory portion by the combination of the medicine of described medicine identification division identification, and according to this comparison decision discharge order.
2. medicine discharger as claimed in claim 1, also comprise the code that invests described liquid reservoir that is used to discern described medicine, and reading described code so that the code reader of acquired information, wherein said medicine identification division is discerned described medicine according to the information that is obtained by described code reader.
3. medicine discharger as claimed in claim 1, wherein said medicine discharge section comprises the electricity-thermal conversion element that heat energy is put on described medicine, or mechanical energy is put on the motor conversion component of described medicine.
4. medicine discharger as claimed in claim 1, wherein, when described medicine by being stored in discharge in the described memory portion when being defined as first medicine and second medicine in proper order, described first medicine strengthens in the body of described second medicine to be renderd a service.
5. medicine discharger as claimed in claim 1, wherein, when described medicine by being stored in discharge in the described memory portion when being defined as first medicine and second medicine in proper order, described second medicine reduces described first side effects of pharmaceutical drugs.
6. medicine discharger as claimed in claim 4, wherein said first medicine has bronchiectasic effectiveness, and described second medicine is intended to be used to stride the lung absorption or be used for deep lung disease treatment.
7. medicine discharger as claimed in claim 6 wherein saidly is intended to be used to stride the medicine that lung absorbs and comprises Remedies for diabetes.
8. medicine discharger as claimed in claim 6, wherein said pharmaceutical pack insulin-containing or the GLP-1 that is intended to be used to stride the lung absorption.
9. medicine discharger as claimed in claim 4, wherein said first medicine is the DPP-4 inhibitor, and described second medicine is GLP-1.
10. medicine discharger as claimed in claim 4, wherein said first medicine comprises analgesic or spice, and described second medicine is intended to be used to stride the lung absorption or be used for deep lung disease treatment.
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| Application Number | Priority Date | Filing Date | Title |
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| JP2006192905 | 2006-07-13 | ||
| JP2006192905 | 2006-07-13 | ||
| JP2007158603 | 2007-06-15 |
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| CN101104090A CN101104090A (en) | 2008-01-16 |
| CN100553705C true CN100553705C (en) | 2009-10-28 |
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| US5002048A (en) * | 1989-12-12 | 1991-03-26 | Makiej Jr Walter J | Inhalation device utilizing two or more aerosol containers |
| US5522798A (en) * | 1994-10-17 | 1996-06-04 | Abbott Laboratories | Control of a multi-channel drug infusion pump using a pharmacokinetic model |
| EP1110567A1 (en) * | 1999-12-24 | 2001-06-27 | B. Braun Melsungen Ag | Infusion device with several infusion pumps |
| EP1317939A2 (en) * | 2001-12-04 | 2003-06-11 | Hewlett-Packard Company | Applicator for dispensing bioactive compositions and methods for using the same |
| CN1498663A (en) * | 2002-10-31 | 2004-05-26 | ��������˹�����տ����� | Inhaling device for transferring variable dose having different components, and its method |
| CN1671428A (en) * | 2002-08-08 | 2005-09-21 | 株式会社根本杏林堂 | Medicine liquid injection device for injecting plural kinds of medicine liquid without mixing them |
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2007
- 2007-07-13 CN CNB2007101291413A patent/CN100553705C/en not_active Expired - Fee Related
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5002048A (en) * | 1989-12-12 | 1991-03-26 | Makiej Jr Walter J | Inhalation device utilizing two or more aerosol containers |
| US5522798A (en) * | 1994-10-17 | 1996-06-04 | Abbott Laboratories | Control of a multi-channel drug infusion pump using a pharmacokinetic model |
| EP1110567A1 (en) * | 1999-12-24 | 2001-06-27 | B. Braun Melsungen Ag | Infusion device with several infusion pumps |
| EP1317939A2 (en) * | 2001-12-04 | 2003-06-11 | Hewlett-Packard Company | Applicator for dispensing bioactive compositions and methods for using the same |
| CN1671428A (en) * | 2002-08-08 | 2005-09-21 | 株式会社根本杏林堂 | Medicine liquid injection device for injecting plural kinds of medicine liquid without mixing them |
| CN1498663A (en) * | 2002-10-31 | 2004-05-26 | ��������˹�����տ����� | Inhaling device for transferring variable dose having different components, and its method |
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| CN101104090A (en) | 2008-01-16 |
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